The aim of the topic on click chemistry is used to synthesize various derivatives of 1, 2, 3-triazol-1-yl piperazine, 1, 2, 3-triazol-1-yl quinoxaline, one pot 1,2,3-triazole and bistriazole. These various synthesized compounds were biologically active such as antimicrobial, anti-oxidant, anticancer, antiviral, anti HIV and antitubercular activates. The heterocyclic compounds which are pharmacological active were synthesized by the Cu (I)-catalyzed Huisgen 1, 3-dipolar cycloaddition is a major example based on the click chemistry philosophy. The click chemistry in a broad sense is about using easier reactions to make compounds for certain functions of drugs. The click chemistry used as a green synthesis, because it allows the basic principles of green chemistry given by Anastas and Warner.
Part of the book: Green Chemistry
The regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles derivatives from substituted alkynes and organic halides with sodium azide by using CuI catalyst in polyethylene glycol-400 as a green reaction media. This process is of considerable synthetic advantages in terms of green principles, high atom economy, low environmental impact, mild reaction condition, high purity and good yields. We find out the use of eco-friendly solvent like mixture of PEG-400 and water for the synthesis of 1,2,3-triazole. The main aim of this research is to found the method which required very short time, cost effective, feasible and a green method as compared to known reported for synthesis of 1,2,3-triazole as a medicinally important scaffold by click chemistry.
Part of the book: Green Chemistry Applications