Pinakin Gunvant Davey

By Elliot M. Kirstein, Ahmed Elsheikh and Pinakin Gunvant

Part of the book: Glaucoma

By Pinakin Gunvant Davey

Part of the book: Ophthalmology

By Pinakin Gunvant Davey

Part of the book: Ophthalmology

By My Diep and Pinakin Gunvant Davey

Glare is the result of veiling luminance from the different light sources we are exposed to in our everyday lives. The luminance from glare can cause problems ranging from the discomfort of our eyes to vision loss. All individuals are affected by glare issues but those problems are intensified in patients living with ocular diseases. Therefore, understanding the effects of glare is applicable to elucidating visual function and pathology. This makes glare testing highly necessary in both clinic and research. However, there are many components involved in glare testing that makes attaining valid results difficult. This is evident in the flaws of current glare devices and the lack of a standardization of measuring glare. Despite the insufficiency of most glare devices, evaluating those weaknesses can potentially lead to a better understanding of glare and glare testing.

Part of the book: Causes and Coping with Visual Impairment and Blindness

By Govindasamy Kumaramanickavel, Siddhita Jadhav, Sugirdhana Parthiban Ramsait and Pinakin Gunvant Davey

Glaucoma is in the top five age-related eye disorders with increasing prevalence globally. Past research has led to the understanding of glaucoma as a neurodegenerative disease. Glaucoma phenomics could be syndromic or non-syndromic. Globally primary open angle, primary angle closure and primary pseudoexfoliation glaucomas are widely present. The genetics and genomics of glaucoma are heterogeneous, both clinically and genetically. Glaucoma has heritability associations, particularly with central corneal thickness, retinal nerve fibre layer and peripapillary atrophy. Ocular embryogenesis genes when mutated could cause either local (in situ), pan-ocular or systemic syndromic glaucoma phenomics. In glaucoma, except for a few single gene causes, most of the associations have been shown with innumerable gene single-nucleotide polymorphisms and epigenetic factors. The biological mechanisms in glaucoma are mechanical strain, inflammation, oxidative stress, vascular dysregulation, and immune imbalance, which independently or collectively contribute to the neurodegeneration and visual morbidity. Biomarkers in glaucoma have experimental study biases and therefore today we cannot apply them effectively in clinical practice and henceforth that demands further research to understand the fundamental basis of the disease. However, the knowledge gained in research will translate into early detection and biomolecular interventional strategies, having traction toward personalised medicine.

Part of the book: Glaucoma