Chapters authored
Quality Control of Formulated Medicines
Part of the book: Latest Research into Quality Control
An Overview of the Establishment of Methodology to Analyse up to 5g-Sample by k0-Instrumental Neutron Activation Analysis, at CDTN, Brazil
The team of the Laboratory for Neutron Activation Analysis, Brazil, has been continuously improving the k0-instrumental neutron activation analysis, the k0-INAA method, having Jožef Stefan Institute, Slovenia, as partner researcher of the neutron activation technique. The group aims at answering the analytical requests of customers and the needs of the researches developed by the lab. The latest improvement was to establish a methodology to analyse up to 5 g-samples. The usual procedure in neutron activation analysis is to determine elemental concentrations in small samples of about 200 mg, a geometrical point source. The reason why these samples are used is that this geometry brings about a number of simplifications during irradiation and gamma spectrometry. This paper describes the steps carried out in the development of the large sample methodology that has already been published elsewhere and has been applied successfully. The results of some reference materials and samples are displayed. It is important to mention that this research has confirmed that any other laboratory applying k0-INAA is able to establish this methodology without having to modify its facilities, since the neutron self-shielding, gamma attenuation, and detector efficiency over the volume source are established.
Part of the book: Advanced Technologies and Applications of Neutron Activation Analysis