Summary of nuclear, mitochondrial and plastid DNA regions used for identification in Rhodophyta [51].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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University",institutionURL:null,country:{name:"Pakistan"}}}]},book:{id:"8602",title:"Groundwater Hydrology",subtitle:null,fullTitle:"Groundwater Hydrology",slug:"groundwater-hydrology",publishedDate:"March 4th 2020",bookSignature:"Muhammad Salik Javaid",coverURL:"https://cdn.intechopen.com/books/images_new/8602.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"208759",title:"Dr.",name:"Muhammad Salik",middleName:null,surname:"Javaid",slug:"muhammad-salik-javaid",fullName:"Muhammad Salik Javaid"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11518",leadTitle:null,title:"The Acoustics of Materials - New Approaches",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThis book should describe in detail sound propagation, process, and characteristics, hearing, and process of speech communication, sound absorption, noise acceptance, the fundamental process of acoustic and how the workplace can be designed to control the surrounding sound and its effects on workers. Use theory and possible practical application to drive the knowledge from human involvement in workplace activities to any possible risk of health and safety hazards of the job.
",isbn:"978-1-80356-651-1",printIsbn:"978-1-80356-650-4",pdfIsbn:"978-1-80356-652-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"769f942393275479acca64e4f4fea958",bookSignature:"Dr. Bankole Kolawole Fasanya and Dr. Sridhar Krishnamurti",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11518.jpg",keywords:"Frequency, Sound Power, Absorption, Noise, Soundproof, Reflection, Inverse Square, Perception, Signal, Background Noise, Building, Noise Barrier",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 18th 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Fasanya is an Assistant Professor at Purdue University, USA. Prior to his current position, he has worked in different capacities with different institutions: Senior research associate (Auditory Protection and Prevention - US Army Aeromedical Research Laboratory, Adjunct Assistant Professor-NCAT, Facilities Engineer MVA, etc). Dr. Fasanya holds a Ph.D. in Industrial and systems engineering with a specialization in ergonomics and human factors.",coeditorOneBiosketch:"Dr. Sridhar Krishnamurti is a Professor and Program Director of Audiology at Auburn University. Sridhar has\r\nauthored a book, journal articles, and book chapters in Audiology and Hearing Conservation. He\r\nis a recipient of several Research grant awards, including the 1999 New Investigator Research\r\nAward from the American Academy of Audiology and the 2011 Auburn University Alumni\r\nUndergraduate Teaching Excellence and 2012 Auburn University Faculty Research Awards.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"214494",title:"Dr.",name:"Bankole",middleName:"Kolawole",surname:"Fasanya",slug:"bankole-fasanya",fullName:"Bankole Fasanya",profilePictureURL:"https://mts.intechopen.com/storage/users/214494/images/system/214494.jpg",biography:"Bankole K. Fasanya received a BSc in Mechanical Engineering in 1999 from The Polytechnic Ibadan, Nigeria, his Master’s degree in Industrial and Systems Engineering from Morgan State University, Maryland, USA and his doctorate degree in Industrial and Systems Engineering specialized in ergonomics and human factors from North Carolina Agricultural and Technical State University, USA. His research focuses on human and environmental safety, ergonomics and human factors, auditory prevention and protection and noise assessment and control at workplaces. Dr. Fasanya is currently an assistant professor at Purdue University Northwest in Indiana, USA. He currently serves as one of the executive members of the American Hearing Conservative Association (NHCA). He is an OSHA-Authorized general industry safety train the trainer and a certified occupational hearing conservationist (COHC).",institutionString:"Purdue University Northwest",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Purdue University Northwest",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:{id:"466252",title:"Dr.",name:"Sridhar",middleName:null,surname:"Krishnamurti",slug:"sridhar-krishnamurti",fullName:"Sridhar Krishnamurti",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RKaOOQA1/Profile_Picture_2022-04-08T11:15:28.jpg",biography:"Dr. Sridhar Krishnamurti is a Professor and Program Director of Audiology at Auburn University.\r\nHe has served on the research grants review panel for several agencies and journals including\r\nAlzheimer’s Association, DOD Hearing Restoration Research, Ear and Hearing, American\r\nJournal of Public Health, and Journal of the American Academy of Audiology. Sridhar\r\nKrishnamurti has served as the past-continuing education administrator for Audiology Special\r\nInterest Divisions 6-9 and a Fellow of the American Academy of Audiology. Sridhar has\r\nauthored a book, journal articles, and book chapters in Audiology and Hearing Conservation. He\r\nis a recipient of several Research grant awards, including the 1999 New Investigator Research\r\nAward from the American Academy of Audiology and the 2011 Auburn University Alumni\r\nUndergraduate Teaching Excellence and 2012 Auburn University Faculty Research Awards.\r\nSridhar is currently President of the Council of Au.D Programs and an Executive Council member\r\nfor the National Hearing Conservation Association. His research has been funded by Oak Ridge\r\nAssociated Universities (ORISE) program and CDC-NIOSH.",institutionString:"Auburn University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Auburn University",institutionURL:null,country:{name:"United States of America"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"429342",firstName:"Zrinka",lastName:"Tomicic",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/429342/images/20008_n.jpg",email:"zrinka@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"7620",title:"Safety and Health for Workers",subtitle:"Research and Practical Perspective",isOpenForSubmission:!1,hash:"1233909d682e2cced428e1042fd40ad4",slug:"safety-and-health-for-workers-research-and-practical-perspective",bookSignature:"Bankole Fasanya",coverURL:"https://cdn.intechopen.com/books/images_new/7620.jpg",editedByType:"Edited by",editors:[{id:"214494",title:"Dr.",name:"Bankole",surname:"Fasanya",slug:"bankole-fasanya",fullName:"Bankole Fasanya"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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The classification of seaweeds has been typically based on their phenotypical features, which include pigmentation and photosynthetic properties. Since the mid-nineteenth century, seaweeds have been empirically distinguished into three main divisions based on their color: red algae (phylum: Rhodophyta) consist of about 6000 species, brown algae (phylum: Ochrophyta) consist of about 1750 species, and green algae (phylum: Chlorophyta) consist of about 1200 species [1]. Until recently, a wide variety of seaweeds and their products have been studied for their industrial, culinary, and renewable energy applications, which include cosmetics, chemistry, paint, medicine, biofuel, etc. [2, 3]. Increasing global demand for seaweed resources and overexploitation of natural seaweeds have highlighted the need for sustainable seaweed cultivation to significantly increase captive production in mariculture systems.
\nAmong all the seaweed-based products, hydrocolloids viz. carrageenans, agar, and alginates continue to be the principal extracts, which received commercial attention through their application in various industries [4, 5].
Emerging applications of hydrocolloids in food industry and other hydrocolloid-related industries have led to an enhancement of the economic values of red algae including
Current practices of seaweed cultivation are predominantly based on traditional methods, where seaweeds are exposed to environmental challenges and pathogens [12, 13]. Most of the seaweeds are cultivated using seedlings produced by vegetative propagation from cultured germplasm. Through this practice, parasites or pathogens from the harvested seaweeds may be re-introduced and subsequently reduced the productivity of the farm. The other logistical problems faced by conventional seaweed farmers include the identification of appropriate sites for farming, labor intensive tasks such as inspection, disease, and seedling losses resulting from extreme weather conditions and water quality. In order to increase the productivity, modern biotechnology via tissue culture can be considered as one of the best options to overcome the conventional breeding challenges including shortage of raw material for planting and seedlings destruction by epiphytes, subsequently facilitate the propagation of high-quality seaweeds [9, 14, 15].
\nThe establishment of an effective seaweed breeding programs is founded on the selection of strains of seaweed with desirable cultural characteristics such as high growth rates, high carrageenan content, disease resistance, and accelerated growth in response to supplemental fertilizers. Phenotypical identification methods are currently the standards by which specific seaweed strains are selected. Although invaluable, morphological characterization can be time-consuming and requires a high level of expertise to discriminate key morphological features indicative of the seaweed species. In addition to this, the physical characteristics of seaweeds tend to be variable as they are directly influenced by environmental factors [16]. Most of these seaweeds cannot be distinguished on the basis of one or collection of specimen using morphological characters alone, and an exhaustive taxonomic study is essential before the variety can be identified. For example, high morphological plasticity within the Hawaiian
To date, the application of different genes for the genetic identification of seaweed species is widely carried out, where the targeted DNA regions are the nuclear, plastid, and mitochondrial DNA (mtDNA). Most molecular characterization targets seaweeds with economic value such as
Nuclear ribosomal regions, which include sequences of large subunit (28S or LSU), small subunit (18S or SSU), and the intergenic transcribed spacers (ITS1, ITS2), can be served as target sites for molecular markers because the ribosomal DNA (rDNA) genes contain both highly conserved and variable regions that can be used as diagnostic tools for certain organisms [28]. The small subunit (18S) and the large subunit (28S) regions are the most used regions for marker development as they are best suited for inference at high taxonomic levels [29]. However, ITS region is often targeted for intraspecific genetic studies in Chlorophyceae (
mtDNA has a higher mutation rate that gives rise to variation in its DNA sequence [34]. mtDNA is usually used to analyze the phylogenetic relationships of groups within a species or individuals that are closely related [35]. The gene map of mtDNA of the red alga,
Loci derived from the chloroplast genome (cpDNA) can be used for the identification of seaweed species due to the low frequency of structural changes and low sequence evolution rate of cpDNA [43]. The cpDNA loci that are routinely used for seaweed identification are the ribulose-1, 5-bisphosphate carboxylase/oxygenase (RuBisCo) gene, specifically the large subunit of the RuBisCo (
Identification of commercially important seaweeds based on standard DNA barcodes or single marker amplification has proven to be useful as the phenotypic plasticity of the species can confound traditional taxonomic approaches. Table 1 showed the summary of nuclear, mitochondrial, and plastid DNA regions that are used for the identification of rhodophyta [51]. Molecular markers are still valuable, despite the increasing popularity of next generation sequencing technologies, where the identity of an unknown seaweed species can be acquired based on a simple polymerase chain reaction amplification and a single sequence read (two sequence reads if both strands are sequenced). Examples of DNA markers used to identify commercially important seaweeds are given in Table 2 [46, 52–57].
\n\n | \n\n | \n |
Small subunit ribosomal DNA | \n\n | \n~1800 | \n
Internal transcribed spacer ribosomal DNA | \n\n | \n~650–1100 | \n
Large subunit ribosomal DNA | \n\n | \n~2700 | \n
\n | \n\n | \n |
Photosystem I P700 chlorophyll a apoprotein A1 | \n\n | \n~1600 | \n
Photosystem I P700 chlorophyll a apoprotein A2 | \n\n | \n1250 | \n
Photosystem II thylakoid membrane protein D1 | \n\n | \n~950 | \n
Plastid LSU (23S) domain V | \n\n | \n~370 | \n
Ribulose-1,5-bisphosphate carboxylase large subunit | \n\n | \n~1350 | \n
\n | \n\n | \n |
Cytochrome c oxidase subunit 1 DNA barcode region | \n\n | \n~664 | \n
Cytochrome c oxidase subunit 1 extended fragment | \n\n | \n~1232 | \n
Cytochrome b | \n\n | \n~940 | \n
Cytochrome oxidase subunit 2-3 intergenic spacer | \n~350–400 | \n
Summary of nuclear, mitochondrial and plastid DNA regions used for identification in Rhodophyta [51].
Nuclear DNA | \n\n | \n | \n |
SSU ribosomal DNA | \nForward primer Reverse primer | \n5′-CAACCTGGTTGATCCTGCCAGT-3′ 5′-TGATCCTTCTGCAGGTTCACCTAC-3′ | \n[52] | \n
ITS ribosomal DNA | \nForward primer Reverse primer | \n5′-TCGTAACAAGGTTTCCGTAGG-3′ 5′-TTCCTTCCGCTTATTGATATGC-3′ | \n[53] | \n
Mitochondrial DNA | \n\n | \n | \n |
\n | \nCOXI43F COXI1549R | \n5′-TCAACAAATCATAAAGATATTGGWACT-3′ 5′-AGGCATTTCTTCAAANGTATGATA-3′ | \n[46] | \n
\n | \nCox2_for Cox3_rev | \n5′-GTACCWTCTTTDRGRRKDAAATGTGATGC-3′ 5′-GGATCTACWAGATGRAAWGGATGTC-3′ | \n[54] | \n
Plastid DNA | \n\n | \n | \n |
\n | \nF7 R753 | \n5′-AACTCTGTAGTAGAACGNACAAG-3′ 5′-GCTCTTTCATACATATCTTCC-3′ | \n[55, 56] | \n
RuBisCo spacer | \nForward primer Reverse primer | \n5′-TGTGGACCTCTACAAACAGC–3′ 5′-CCCCATAGTTCCCAAT-3′ | \n[57] | \n
Examples of DNA markers used for seaweed identification.
Ambiguous nucleotide codes according to IUPAC: K=G/T, R=A/G, W=A/T, D=A/G/T.
Quantitative trait locus (QTL) analysis is a statistical method that links two types of information, phenotypic data (trait measurements) and genotypic data (usually molecular markers), in an attempt to explain the genetic basis of variation in complex traits [58]. A wide range of agronomic traits in crop plants, including plant productivity and stress tolerance, are complex traits controlled by QTLs [59]. Identification of these QTLs will facilitate the development of novel varieties of seaweeds via conventional breeding approaches as well as genetic engineering. A (QTL) is a region of DNA (the locus) that correlates with variation in a phenotype, which is designated as the “Quantitative Trait”. The QTL contains the genes that encode for the phenotype is tightly linked to the trait over successive generations. Traits of agronomic importance may be controlled by a single gene or in most cases by multiple genes. For example, if we bred a disease tolerant seaweed with a seaweed that yields a high amount of carrageenan, we can generally assume that the resultant hybrid will be a high yielding, disease tolerant variety. This is a generalized assumption based on the hypothesis that the traits are discrete (Figure 1). Markers are generally selected based on regions that flank the quantitative trait (Figure 2) and these can be validated over successive breeding cycles.
\nThe gene encoding the quantitative trait is designated as a quantitative trait locus (QTL). The genetic markers for this trait can be located with the gene itself; however, in most cases, breeders will utilize the regions flanking the locus to design the markers. This is to ensure that the QTL can be tracked over successive breeding cycles and the markers are tightly linked to the QTL.
The ideal set of markers for QTL mapping is located on either side of the QTL and at a map distance of 4–10 cM on either side of the QTL. This ensures reliability over several cycles of recombination due to tight linkage.
However, it should be noted that the majority of traits are not discrete. Analysis of hybrids reveals that segregating populations consist of individuals with continuous traits. In the case of seaweeds, one example of this class of QTL can be the diversity of pigmentation observed in variants of
Commercial breeders adopt a range of approaches in order to integrate diverse traits in order to produce an elite strain with all the desired agronomic traits. This approach entails the selection of wild genotypes purely on the basis of their phenotypic characters. This is an ideal strategy to adopt in the case of seaweeds, where no established elite strains exist. Marker-assisted gene pyramiding aims to produce individuals with superior economic traits according to the optimal breeding scheme, which involves selecting a series of favorite target alleles after cross of base populations and pyramiding them into a single genotype [60]. The strategy for pyramiding is depicted in Figure 3.
\nMarker-assisted pyramiding of ideal agronomic traits in seaweeds. In this scheme, six varieties with the desired traits are merged into one ideotype over successive breeding cycles. The loss or integration of QTLs can be assessed at every generation using polymerase chain reaction (PCR)-based molecular markers.
An alternative approach which can be undertaken when a grower has an elite strain, which needs to be supplemented with additional traits is backcrossing with the parental genotype over successive generations. This approach (Figure 4) mitigates the likelihood of genes encoding for undesired traits from the wild type from manifesting in the hybrid phenotype.
\nMarker-assisted backcrossing using molecular markers can be applied in circumstances, where it is necessary to improve the elite strain.
The first step in developing a linkage map using QTLs involves information pertaining to phenotypes and their association with specific genotypes [61]. Ideally, molecular breeding should commence with the collection of all the available phenotypes from the wild. The second step will be the identification of specific traits, which are associated with each phenotype; once this has been established, the third step will involve the elucidation of genomic information and its conversion into suitable molecular markers. This can be done using available genomic information or on the basis of expressed sequence tags (ESTs) [62–64]. Seaweeds, unlike terrestrial plants, have unusual breeding cycles [65] and the mechanism need to be established prior to commencing a defined breeding program. New insights into the draft genomes of
Current research work on QTL mapping in seaweeds has focused on commercially cultivated species, which are
Marker-assisted selection is defined as an indirect selection method of an individual with desired traits in a breeding program based on DNA markers [74]. The important of MAS in a seaweed breeding program is to obtain basic genetic knowledge of the chosen commercially important seaweed. Some desired seaweed traits, such as crop yield or phycocolloid content, may be controlled by one gene or a group of genes. Therefore, it is beneficial to develop markers for a range of commercially important seaweed species to provide the foundation needed for MAS in the seaweed breeding program [75].
\nIn seaweed farming, specifically for the phycocolloid industry, the desired traits of seaweed would be disease resistance, suitable carrageenan content, high productivity, and yield. These desired characteristic or traits can be genetically simple, where only one gene is involved. However, most economically important crops tend to have traits that are genetically complex, where it is controlled by many genes (QTL) and the environment [75]. For example, Babu et al. [76] had detected a total of 47 QTLs for drought resistance traits from various plant water stress indicators to increase production and yield of rice in rainfed agriculture ecosystems. To date, there are no reports in the literature of the application of MAS in seaweed breeding program. Recently, Maili et al. [77] had successfully developed eight out of 112 single loci DNA markers to discriminate between varieties of
Repeated vegetative propagation applied in conventional seaweed cultivation was found decreasing genetic variability of seaweeds and subsequently contribute to the decreased in growth rates and yields and increased susceptibility to diseases [78]. Micro-propagation via tissue culture technology has been proposed as an alternative method compared to conventional breeding to resolve the seedling shortage problem and increase the productivity of seaweed raw materials. Micro-propagation is a versatile tool to produce high number of uniform specimens from selected strains with desirable characteristics and increase seed stock production in shorter period of time [79]. However, challenges including lack of optimized protocols to obtain axenic cultures and regeneration of explants have limited the widespread use of tissue culture technology in commercial seaweed production. The efficacy of seaweed tissue culture is depends on the effective manipulation of endogenous (age, source, developmental stage, and physiological state of explants) and exogenous (media composition, light, salinity, pH, and temperature) factors [80, 81]. Current researches have been strategized to improve the culture conditions for mass production of high-quality laboratory seedlings to enhance the overall productivity of seaweed cultivation [3, 9, 14, 15].
\nExplants have to be sterilized in order to obtain the axenic cultures for mass propagation in tissue culture [82]. Seaweed samples collected from the wild are associated with a significant level of biological contamination, which is likely to be commensal or symbiotic; therefore, it is necessary to surface sterilize the explants with general disinfectants as well as targeted antibiotics prior to cultivation. Povidone iodine and alcohol are common disinfectants used for surface sterilization as they have a localized activity compared to the narrow spectrum antibiotics with their functionality limited to specific classes of microbes [83]. Surface sterilization of seaweeds is difficult as they lack of thick protective surface, and therefore, sodium hypochlorite and similar agents can easily damage the tissues especially newly regenerated thallus [84]. Prolonged exposure of explants to excessive disinfectants (e.g., more than 5 min in 2% betadine and more than 72 h in 5% antibiotic mixture) was reported causing patches of damaged surface on thallus and explants [85].
\nCulture media commonly used for rapid propagation of rhodophyte are reported to be Provasoli’s enriched seawater (PES) [86], seawater supplemented with von Stosch (VS) solution [87], and seawater enriched with half strength “f medium” (F/2) [88]. The selection of culture media for seaweed propagation is highly dependent on the nutrient level, ambient water, and cultured species. The optimized culture medium for economically important
The addition of plant growth regulators and their role in seaweed tissue culture have been extensively reviewed [92–94]. Cellular competence to plant hormones in cultivated seaweeds is significant only if the cells possess ability to perceive, transduce, and respond to the hormonal signal [95]. The common plant hormones used in seaweed tissue culture are auxins (indole-3-acetic acid, 2,4-dichlorophenoxyacetic acid), cytokinins (benzyadenine, isopentenyladenine, kinetin), and gibberellins (gibberellic acid). The presence of phytoregulators in tissue culture medium is known to be able to stimulate tissue elongation and contributes to the overall plant growth [15]. Generally, auxins are used to increase protein synthesis, induce morphogenesis, and elicit changes in genetic expression of explants [96], while cytokinins are used to stimulate cell division, enhance metabolic activities, and affect cell differentiation in seaweed tissue cultures [97]. Combination of auxins (α-naphthalenacetic acid and phenylacetic acid) and cytokinins (N6-(2-isopentenyl) adenine and 6-benzylaminopurine) has been reported to induce the highest callus growth in
The organic requirements for axenic seaweed culture are remained unclear although additions of organic complexes (coconut milk, yeast, and algal extracts) to increase the growth rates of seaweed tissue have been reported [99]. Three commercially available formulated fertilizers and biostimulant in global market for seaweed cultivation are Acadian marine plant extract powder (AMPEP), Gofar600 (GF), and natural seaweed extract (NSE). AMPEP is extracted from
Studies on optimizing the growth of economically important seaweeds, especially
Light source is one of the most important parameters to be optimized in seaweed cultivation. The intensity, wavelength, and spectral quality of light, all influence the photosynthetic productivity of algae. Different strains or varieties of seaweed may exhibit different optimum growth range and tolerance to different light resources.
Aeration is an ideal method of energy transfer; whereby, atmospheric carbon dioxide is diffused into the culture medium. Continuous aeration is an important process to provide enough carbon dioxide for carbon fixation in seaweed metabolism. Meanwhile, carbon source can be provided in the organic form such as glycerol yet the addition of glycerol in the culture medium was found to reduce the morphogenetic capacity and totipotency of the explants [111]. Continuous aeration (at 30.0 L h−1) was found to significantly enhance the growth of
Salinity is reported to be one of the factors affecting the growth [15, 80] and exerting strong influences on the photosynthetic capacity [117, 118] of the cultured seaweeds. Prolonged exposure to low salinity may induce stress that led to reduced photosynthetic efficiency, inhibited cell division, and subsequently result in stunted growth and declined in growth rate [80].
The ordinary seawater is slightly alkaline (pH ~8) with bicarbonate ions (HCO3\n−) constituted about 91% of total dissolve inorganic carbon (DIC), followed by 8% of carbonate ions (CO3\n2−), and 1% of dissolved CO2 [123]. Alterations in seawater pH may vary the equilibrium of carbonate system and change the concentration of inorganic carbon species [124], subsequently affect the growth of seaweeds which depend on the supply of inorganic carbon for photosynthesis. The pH range for normal growth of most seaweed cultures was reported to be 7–9 with optimum growth in between 8.2 and 8.7 [125].
In order to maximize the growth of micro-propagules and enhance the productivity of seaweed propagation, incorporation of optimized parameters in their combination in tissue culture system (Figure 5a) and application of photobioreactor with optimal growth condition (Figure 5b) are highly recommended. Maximum DGRs of
(a) Tissue culture and (b) photobioreactor cultivation of
Although macroalgal tissue culture is underdeveloped relative to that of land plants, there are more than 85 species of seaweeds from which tissue culture aspects including successful callus formation, plant regeneration, somatic embryogenesis, and thallus development have been reported [92, 127]. Exploitation of seaweed organogenetic potential for the isolation of superior clones has been initiated since the late twentieth century to improve the performance of cultivated species including
While the studies of seaweed tissue culture and micro-propagation have been reported from various literatures, information about acclimatization and successful out-planting of tissue-cultured seedlings are still limited to date. Acclimatization to ex vitro conditions (nursery or glasshouse) is necessary to provide a buffer condition to the seaweed cultures for suitable adaptation before their exposure to the complex open sea environment [9]. Direct planting out of tissue-cultured seaweeds without going through the acclimatization phase may cause stress and shock to the seedlings due to sudden changes in environmental conditions [101]. Therefore, effective acclimatization process is considered to be a key element to enhance the survival rate of tissue-cultured seaweeds after they have been out-planted to the open sea.
\nTransferring of micro-propagated
Acclimatization of micro-propagated
Furthermore, acclimatization of
Comparison of the quality between tissue-cultured and conventional cultivated
Comparison of growth rate and quality between (a) tissue-cultured and (b) conventional cultivated
Carrageenan properties | \nTissue cultured | \nConventional cultivated | \n
---|---|---|
Yield (%) Viscosity (cP) Gel strength (g cm-2) Sulphate content (%) | \n67.3 ± 16.4 1280.0 ± 25.0 703.5 ± 14.1 34.2 ± 10.9 | \n51.5 ± 21.0 87.8 ± 20.9 288.3 ± 19.3 7.5 ± 6.7 | \n
Semi-refined carrageenan properties of tissue cultured and conventional cultivated
In terms of other chemical composition, tissue-cultured
Public concern of endocrine-disrupting chemicals (EDCs) has been rising since the 1990s. EDCs are defined as “an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations” [1, 2, 3]. EDCs are found in many products comprising plasticizers, personal care products, pesticides… [1]. Humans are constantly exposed to several different EDCs by ingestion, inhalation, and dermal contact. Some classes of EDCs have been studied in detail. Here, we selected three classes of EDCs based on knowledge of their effects on Hypothalamo-Pituitary-Gonadal (HPG) axis: bisphenol A (BPA), phthalates and dichlorodiphenyltrichloroethane (DDT). BPA is one of the most massively produced EDC with over three million tons manufactured annually [4]. It is used in food packaging, toys, resins used in canned, and medical equipment. Because its incomplete polymerization and its release from polycarbonate at high temperature, exposure to BPA is important
The GPCRs are the largest family of cell-surface receptors with over 800 members accounting for 4% of the encoded human genome [10]. About half of them have sensory functions, mediating olfaction, taste, light perception, and pheromone signaling. The other half (~350–400) are called endo-receptors, i.e. receptors that interact with endogenous ligands [11]. These receptors are involved in the detection of many extracellular stimuli (from photons or ions to large hormones proteins). Thus, they have important roles in various physiological systems. Dysfunction of GPCRs contributes to many human diseases and GPCRs represent 34% of all Food and Drug Administration-approved drugs [12].
GPCRs are characterized by a common structure with seven transmembrane helices with an extracellular N terminus and an intracellular C terminus [13]. The N-terminal portion, or transmembrane domain, constitute the ligand binding site while the C-terminal portion and the intracellular loops form a coupling domain with the intracellular effectors [14].
In the classical GPCR signaling pathway, after ligand binding, activated-GPCR binds the intracellular heterotrimeric G proteins, promoting the release of GDP from the Gα subunit, exchanged for GTP and the dissociation of the GTP-bound α subunit from βγ dimers. The activated G proteins can then transduce and amplify GPCR signals via second messengers to produce a variety of cell responses [15]. Briefly, G
The Hypothalamo-Pituitary-Gonadal axis is active in the midgestational fetus and after birth at the minipuberty but is mainly reactivate at onset of puberty. Some receptors of the HPG axis belong to the subfamily of GPCR: gonadotropin-releasing hormone receptor (GnRHR), GPR54/Kisspeptin receptor, Neurokinin B receptor (NK3R), Prokineticin receptor (PROKR2), follicle stimulating hormone receptor (FSHR), human chorionic gonadotropin/luteinizing hormone receptor (hCG/LHR) and Relaxin Family Peptide Receptor 2 (RXFP2).
The GnRH, a neuropeptidic hormone, is secreted by hypothalamic GnRH-expressing neurons into the portal blood vessels in rhythmic pulses [19]. It binds to a membrane receptor, the GnRH receptor, also known as the luteinizing hormone releasing hormone receptor (LHRHR), on pituitary gonadotropic cells and stimulates the biosynthesis and secretion of LH and FSH [19]. GnRHR is predominantly coupled to the Gq-protein [20]. GnRH/GnRHR pathway constitutes the initial step in the HPG axis and controls reproduction in both sexes. GnRH loss-of-function mutations are associated to normosmic hypogonadotropic hypogonadism [21]. GnRH neurons appear to be directly regulated by Kisspeptin-1 (KISS1), with Neurokinin B (NKB) and Prokineticin 2 (PROK2). KISS1 is a peptidic hormone mostly expressed in the hypothalamus [22]. It activates GPR54/KISS1R, which results in the activation of phospholipase C
Gonadal function is under pituitary control
Steroid hormones (estrogen, progesterone, and testosterone) secreted by the gonads, bind, and activate nuclear receptors. However, a membrane associated estrogen receptor (GPER) has been identified 15 years ago [31, 32]. Activation of GPER induces intracellular calcium mobilization, cAMP production and phosphorylation cascade involving ERK1/2, PKA, PI3K [33]. This receptor is implicated in many physiological functions: uterine proliferation, metabolism, cardiovascular, immune, and neural system.
More recently, the INSL3/RXFP2 system pathway was identified for its role in reproduction. Insulin-like peptide-3 (INSL3) belongs to the insulin/relaxin family of peptidic hormones [34, 35]. This hormone is mainly produced by testicular Leydig cells and the production is dependent on the state of Leydig cell differentiation [34]. INSL3 is considered as a marker for Leydig cells function. Its best characterized role is in the control of testicular descent since
Effects of EDCs on the activity of HPG axis GPCR identified in the literature search are summarized in Table 1.
GPCR | EDC | Study model | Main results | |
---|---|---|---|---|
FSHR | DBP [ | Human granulosa cells | DBP increases FSHR expression | [38] |
DDT [ | CHO-K1 - hFSHR | DDT decreases cAMP production stimulated by FSH | [39] | |
DDE [ | Human granulosa cells from IVF | DDE potentiates the FSH induced aromatase activity | [40] | |
DDT [ | CHO-K1 - hFSHR | DDT is an FSHR positive allosteric modulator | [41] | |
BPA [ | CHO-K1 - hFSHR | BPA decreases cAMP production stimulated by FSH | [41] | |
hCG/LHR | BPA [ | Human endometrial stromal cells | BPA decreases hCG/LHR expression | [42] |
DDT [ | CHO-K1 - hCG/LHR | DDT decreases cAMP production stimulated by hCG/LHR | [41] | |
RXFP2 | DEHP [ | HEK293 - hRXFP2 | DEHP increases cAMP production stimulated by INSL3 | [43] |
DBP [ | DBP increases cAMP production stimulated by INSL3 | |||
BPA [ | HEK293 - hRXFP2 | BPA increased cAMP production stimulated by INSL3 | ||
DEHP + DBP + BPA [ | HEK293 - hRXFP2 | DEHP+DBP + BPA mixture decreases cAMP production stimulated by INSL3 | ||
GPER | BPA [ | Human breast cancer cells | BPA increases GPER expression | [44] |
BPA [ | Human testicular seminoma cells | BPA promotes cellular proliferation | [45] | |
BPA [ | HEK293 - hGPER | BPA is a GPER agonist and induces the Gs protein pathway | [46] | |
BPA [ | Human breast and lung cancer cells; cancer-associated fibroblasts | BPA induces ERK1/2 activation and gene expression through GPER leading to cellular proliferation and migration | [47, 48] | |
BPA [ | Human granulosa cells | BPA induces apoptosis | [49] | |
o,p’-DDE [ | Human breast cancer cells | o,p’-DDE is a GPER agonist and induces the Gs protein pathway | [32, 46] |
Experimental studies studying the effect of EDC on HPG axis GPCR signaling.
Currently, there are no data on the effects of EDCs on the activity of human hypothalamic hormone receptors. However, some studies have been conducted with animal models. Exposure to phthalates leads to a modulation of GnRHR expression (positive or negative depending on the studies) [50, 51], as well as an increase in its expression in rat uterus [52].
EDCs, like phthalates, increase the FSHR expression in human granulosa cells [38]. DDT has been shown to disturb the FSH induced-cAMP accumulation [39] and aromatase activity in human granulosa cells [40]. Recently, we showed that DDT behaves as an FSHR positive allosteric modulator [41]. DDT interacts with the receptor in the minor binding pocket in the transmembrane domain. DDT acts on the early steps of activation of the FSHR and induces an increase in FSH-stimulated cAMP production. Moreover, the binding of DDT enhances the FSHR response to hCG. The increased response to FSH in the presence of DDT and the gain of sensitivity to hCG may therefore by deleterious. In opposite, BPA is a FSHR negative allosteric modulator [41].
As for FSHR, EDCs, like BPA, disturbes the expression of hCG/LHR in human endometrial stromal cells [42]. In CHO-K1 cells stably transfected with hCG/LHR, DDT reduced the cAMP accumulation induced by hCG [39, 41] and hLH (Munier et al., Arch Toxicol, in revision). Moreover, DDT decreases the hCG- and hLH-promoted β-arrestin 2 recruitment (Munier et al., Arch Toxicol, in revision). DDT seems to act as a negative allosteric modulator of the hCG/LHR signaling.
Only one study has very recently focused on the effect if EDCs on receptor signaling to INSL3: RXFP2. In a cellular model of HEK293 transiently expressing human RXFP2, individually, BPA, DEHP and DBP potentiate the cAMP response to INSL3 [43]. Because of their ubiquity, BPA, DEHP and DBP are present in many human biological fluids, as the amniotic liquid. Furthermore, everyone is chronically exposed to mixtures of environmental chemical factors resulting in toxicological interactions that cannot be predicted by reprotoxicological studies of single molecules. The combination of these three molecules, at concentrations found in human amniotic fluid, decreases the basal activity of RXFP2 as well as the response to INSL3. The structural similarity between FSHR and RXFP2 suggests that small hydrophobic molecules, like phthalates and BPA, could use the same binding sites as DDT in FSHR. The binding of one or two compounds to this site could lead to a stabilization of the active state of the receptor driving an increase of agonist activity [53]. In contrast, the binding of three compounds (DEHP+DBP + BPA) likely leads to a steric hindrance that may prevent the conformational changes necessary for the activation of RXFP2 and probably stabilize an inactive state. This study shows that in addition to individual EDC targets, HPG axis GPCRs can also be targeted by EDC cocktails.
The G protein-coupled receptor (GPER/GPR30) is a membrane estrogen receptor [31]. Gene inactivation of
Various DDT derivatives and BPA bind to GPER with a Kd between 1 to 10 μM and are competitors of E2 [46]. The binding affinity of EDCs for GPER is higher than for the nuclear receptors. Nevertheless, low concentrations of o,p’DDE and BPA increased cAMP production by GPER [32, 45, 46]. BPA and phthalate (MEHP) also affect proliferation and migration in human cervical cancer cells [56], in human seminoma cells [45], human breast cancer cells and cancer-associated fibroblasts that lack nuclear ERs [47, 57] as well as the migration and invasion of lung cancer cells [48]. BPA modifies these cellular responses by modulating different intracellular signaling pathways (ERK1/2 or Akt phosphorylation, gene expression) through GPER activation. In opposite, GPER mediates BPA-induced intracellular stress generation (ROS production and calcium accumulation) and apoptosis (caspase activation and mitochondrial membrane potential decrease) in human granulosa cells [49]. Recently, it has also been shown that BPA increases GPER gene expression in breast cancer cell lines [44]. Finally, bisphenols AF and B, two substitutes of BPA, exert high estrogenic effects via GPER pathway at nanomolar concentrations [58, 59].
Effects of EDCs on the synthesis and secretion of HPG axis hormones identified in the literature search are summarized in Table 2.
Study population | EDC exposure | Matrix/biomarker | Main results | |
---|---|---|---|---|
192 mother–child pairs from e-waste recycling town and 70 from control area | Free BPA in cord blood serum | Higher BPA concentrations showed positive correlation with | [60] | |
73 girls with central precocious puberty and 31 controls | Seven urinary phthalate metabolites concentrations | Serum kisspeptin | Positive correlation between kisspeptin- and mono-n-butyl phthalate | [61] |
535 men (18–40 yr) living or not in pesticides contamined area. | Lipid-adjusted DDE and DDT concentrations | Serum FSH, LH, T, E2 | Positive association between DDT or DDE with T | [62] |
749 Swedish (fishermen and their pregnant wife) | p,p′-DDE serum level | Serum FSH, LH, T, E2 | Positive association between DDE and FSH or LH | [63] |
97 adult men living in nothern Thailand | plasma levels of DDT and its metabolites | Serum FSH, LH, T, E2 | Negative association of E2 level with p,p’-DDE and positive association with o,p’-DDE | [64] |
107 males exposed to DDT in Italy | Lipid-adjusted p,p’-DDE and p,p’-DDT serum concentration | Serum FSH, LH, T, E2 | No association with serum hormone levels | [65] |
604 adults (men and women) in Brazil areas exposed to pesticides | Serum concentrations of 19 pesticides including p,p’-DDT and o,p’-DDT | Serum FSH, LH, T, E2 | In men, o,p’-DDT level was associated with lower T, in peri- and postmenopausal women, p,p’-DDT showed inverse associations with LH; No association in premenopausal women | [66] |
234 mothers and their sons | Serum o,p’- and p,p’-DDT, p,p’-DDE from mothers during pregnancy or at delivery and their sons at 9 years. | Serum FSH, LH and T in sons at 12 years | Prenatal maternal DDT and DDE levels were associated with decreases in LH | [67] |
45 girls with early breast development, 16 girls with early puberty, and 33 girls with no signs of puberty | 2,4-DDT and 4,4’-DDE in the serum and adipose tissue samples. | Serum basal and stimulated LH and FSH level | Basal and stimulated LH were higher in girls with detectable serum DDE levels | [68] |
308 young men | Urinary BPA concentrations | Serum LH, T, E2 | Higher urinary BPA concentrations were associated with increased serum T, E2, and LH | [69] |
215 healthy young men (18–23 yr) | Urinary BPA concentrations | Serum FSH, LH, T, E2 | Positive association between urinary BPA and LH levels | [70] |
560 men aged 18–55 years | Urinary BPA concentrations | Serum FSH, LH, T | BPA was associated with increased serum levels of LH and FSH in male smokers, and with decreased serum levels of total T in men with BMI ≥ 25 kg/m2. | [71] |
167 men from an infertility clinic | Urinary BPA concentrations | Serum FSH, LH, T, E2 | Positive association between urinary BPA and serum FSH | [72] |
244 mothers-child pairs | Serum maternal total BPA concentration during second or third trimester | Serum FSH, LH, T, E2 | No association with serum hormone levels | [73] |
159 women with premature ovarian insufficiency and 186 controls | Urinary concentrations of BPA | Serum FSH, LH | No association with serum hormone levels | [74] |
106 BPA-exposed factories and 250 unexposed female workers | Urinary concentrations of BPA | Serum FSH, LH, E2 | Inverse association between BPA and FSH in unexposed group | [75] |
143 healthy, premenopausal women | Urinary concentrations of BPA | Serum FSH, LH, E2 | No association with serum hormone levels | [76] |
172 peripubertal boys | Urinary concentrations of BPA | Serum FSH, LH, T | No association with serum hormone levels | [77] |
130 children with Attention-Deficit/Hyperactivity Disorder and 68 controls (boys and girls) | Urine levels of phthalates and BPA | Serum FSH, LH, T, E2 | Among boys with ADHD, MBzP and MEHP levels were positively correlated with T; among girls, MEP was positively correlated with LH and T | [78] |
136 girls (6–9 yr) with early puberty and 136 controls | Urinary BPA concentrations | Serum basal and stimulated LH and FSH level, E2 | In early puberty group, negative correlation between BPA and peak FSH levels | [79] |
479 pregnant women and their infants (boys and girls) | Urinary 12 phthalate metabolites concentrations at gestational week 28 | Serum T, LH, FSH during mini puberty | No association with serum hormone levels | [80] |
302 Korean children and adolescents | Urinary and serum concentrations of DEHP, MEHP, DBP, MBP | Serum FSH, LH, T, E2 | Positive correlations between serum DBP or MEHP, and E2 and/or LH in children. | [81] |
106 males and females (11–88 yr) | Urinary phthalate metabolites | Serum FSH, LH, T, E2 | Positive associations between MEHP and FSH or T, MEOHP and FSH, LH or T, negative associations between MEHHP and LH, FSH or T | [82] |
88 infertile men | Urinary and serum concentrations of 11 phthalate metabolites | Serum FSH, LH, T | Negative associations between FSH and MiBP and MCMHP; positive association between T and phthalates metabolites. | [83] |
599 infertile men | Urinary concentrations of 8 phthalate metabolites | Serum FSH, LH, T, E2 | Inverse associations between T and MiBP, FSH and MEHHP, positive relationship between E2 and MEP, %MEHP and FSH and LH | [84] |
295 adult men | Urinary concentrations of phthalate metabolites | Serum FSH, LH, T, E2 | Negative association between MBzP and FSH | [85] |
881 healthy men | Urinary concentrations of 14 phthalate metabolites | Serum FSH, LH, T, E2 | %MEHP was negatively associated with T and FSH | [86] |
Male with cryptorchidism (421), hypospadias (109) or controls (425) | 5cx-MEPP, 7cx-MMEHP in amniotic fluid (11–21 weeks) | INSL3, T in amniotic fluid | Negative correlations between INSL3 and cx7-MMeHP and 5cxMEPP | [87] |
1066 Chinese men of reproductive age | Urinary concentrations of 14 phthalate metabolites | Serum levels of INSL3, FSH, LH, T | Negative association between INSL3 and MEHP; negative association between MBP and MiBP with T and LH | [88] |
male partners of subfertile (n = 253) and fertile (n = 37) couples | 11 phthalate metabolites in urine and semen | Serum levels of INSL3, FSH, LH, T, E2 | Negative association between INSL3 and some urinary and seminal phthalate metabolites | [89] |
case–control study of 176 men (fertile and infertile) | Urinary concentrations of 11 phthalate metabolites | Serum levels of INSL3, FSH, LH, T, E2 | inverse association MMP, MiBP, MEHP, MEHP% and T; MBzP and MEHP% were negatively associated with serum INSL3 level | [90] |
102 mother–child pairs | Maternal serum concentration of MEHP (23–35 weeks of gestation | Cord blood INSL3, FSH, LH, T, E2 levels | Inverse associations between maternal MEHP and INSL3 in males | [91] |
52 boys with cryptorchidism and 128 control boys | Cord blood BPA concentration at birth | Cord blood INSL3 levels | Higher cord blood BPA concentrations were associated with reduced cord blood INSL3 levels | [92] |
Human biomonitoring studies addressing the relationship between EDC and hormones of HPG axis.
T: testosterone, E2: estradiol.
No data are available on the impact of DDT on Kisspeptin in epidemiological studies in humans.
Interestingly, a study led on 262 mother–child pairs from China found a positive correlation between cord blood levels of BPA and
For phthalates, linear regression analysis showed increasing trend for kisspeptin secretion with the concentration of urinary phthalates [61].
No epidemiological or experimental studies are available on the possible link between EDC levels and GnRH concentration in human. This is probably explained by the pulsatile nature of its release and the lack of dosage in clinical practice. However, many effects of EDC on GnRH were observed in rodents [93].
DDT is rapidly metabolized in the body to DDE. Thus, in epidemiological studies, DDE is dosed in the blood more often than DDT. In a cohort of men of reproductive age, statistically significant positive association was found between the serum level of DDE and LH or FSH [63]. However, others studies did not reveal any association between DDT and FSH or LH levels in adult men [62, 64, 65]. In peri and postmenopausal women, inverse correlation was found between serum DDT and LH [66]. Moreover, it has been shown that maternal exposure to DDT or DDE, assayed in prenatal serum, induced a reduction of plasma LH in teenage boys, not found for FSH [67]. A study also showed that the serum levels of LH (basal level and after GnRH stimulation) was significantly higher in girls with detectable serum DDE levels than in girls with undetectable DDE [68]. This difference was not found for FSH [68].
For BPA, studies found that higher urinary BPA concentration was associated with significantly higher concentrations of serum LH in healthy young men, with or without association with FSH [69, 70, 71]. However, these results were not confirmed in others cohorts of fertile men [73]. Conversely, another study found a positive correlation between urinary BPA concentration and FSH level, without change in LH level in a cohort of infertile men [72]. In women, no association was found between urinary bisphenol A and LH or FSH levels in premenopausal women [74, 75, 76]. Moreover, no association was found in healthy children for LH and FSH [77, 78]. A modest negative correlation was found between urinary BPA concentration and peak of GnRH-stimulated FSH levels in girls with idiopathic central precocious puberty, without difference for LH levels [79].
Maternal phthalates exposure (urinary samples collected during second trimester) was not associated with serum LH level or FSH in offspring during mini-puberty in boys and girls [80]. However, positive correlations were observed between different phthalates and serum LH in prepubescent Korean children (for serum DBP or MEHP) [81], in girls with attention-deficit/hyperactivity disorder (for urinary MEP) [78] and in Chinese population (11–88 years, males and females) (for urinary MEHHP levels) [82]. In the same populations, either negative [82, 83] or no effects [78, 81] were observed on FSH level. In men, urinary phthalate metabolites were positively associated with LH and FSH levels [84] in one study while negative association between urinary phthalates concentrations and levels of FSH was found in American men (for MBzP) [85] and in Danish men (for MEHP or %MiNP) [86] without impact on LH.
Altogether, epidemiological data have linked exposure to EDC and LH and/or FSH level but evidence were often inconclusive. The inconsistent findings may partly be due to differences in the characteristics and sizes of the cohorts and to the different EDC exposure levels among studies.
Many data are already available on the effect of endocrine disruptors on the secretion of sex steroids. Recent reviews list all available studies for DDT [93], BPA [93, 94] or phthalates [93, 95, 96, 97].
No data are available on the impact of DDT on INSL3 in humans epidemiological studies.
Several studies showed that INSL3 was negatively impacted by putative phthalate metabolites. The Diisononyl phthalate (DiNP) metabolite, cx7-MMeHP, and the DEHP metabolite, 5cxMEPP, showed significant negative correlations with INSL3 in amniotic fluid for weeks 11–22 [87]. Moreover, serum levels of INSL3 was negatively associated with urinary concentration of mono-2-ethylhexyl phthalate (MEHP) and MBzP among large cohorts of chinese men of reproductive age [88, 89, 90]. In adjusted models, quartiles increases in phthalates metabolites correlated with significant decreases in plasma INSL3 levels [88, 89, 90]. It has also been shown that maternal serum MEHP concentration (from 23–35 weeks of gestation) was negatively correlated with INSL3 level in cord blood mainly in boys [91].
There is also an inverse correlation between BPA level and concentration of INSL3 [92]. Indeed, in a population of 180 boys born after 34 weeks of gestation (52 cryptorchid and 128 control), cord blood levels of free BPA correlated negatively with INSL3 [92]. In this study, cord blood INSL3 level was also significantly decreased in the cryptorchid group compared with the control group [92].
No data are available on the impact of DDT on INSL3 in humans experimental studies.
The exposure of fetal testis (8–12 weeks) to BPA at 10−8 M and 10−5 M for 72 h [98], significantly depressed the basal INSL3 production compared with control. This treatment also reduced INSL3 mRNA level by more than 20% [99]. However, BPA did not modify hCG or hLH-stimulated INSL3 production [98]. Conversely, in human adult testes, BPA increased significantly INSL3 production by Leydig cells, at a low doses (10−9 M) [100]. Interestingly, its analogs, Bisphenol B and Bisphenol S also increased INSL3 production at 10−9 and 10−8 M. Moreover, BADGE, another bisphenol, dose dependently increased INSL3 after 48 h of exposure. In contrast, BPE dose dependently inhibited INSL3 levels [100].
For phthalates, di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) exposition on organo-cultured adult human testis did not affect Leydig cell INSL3 concentrations [101].
Most epidemiological and experimental studies focus on the effect of EDCs on the expression and secretion of hormones, as well as on the activity of nuclear steroid receptors. However, a few experimental studies have shown that G protein-coupled membrane receptors of the HPG axis are targets of EDCs as well. It can be pointed out that most of the studies analyzing the effects of EDCs on GPCRs of HPG axis have been performed with cell culture systems.
Mechanisms of GPCR disruption by EDCs include: (1) changes in the expression; (2) interaction with transmembrane domain receptor; (3) modulation of intracellular signaling pathways.
The GPCRs of HPG axis, involved in diverse physiological functions, should be considered as possible contributors of the adverse effects of EDCs on reproduction. How their modulation by EDCs contributes to these deleterious effects should be an important field of investigations in the near future.
V.S was supported by funding from La Société Française d’Endocrinologie. MM was supported by funding from La Société Française d’Endocrinologie et de Diabétologie Pédiatrique and Novo Nordisk.
The authors declare no conflict of interest.
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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. 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He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. Aljaser",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"428600",title:"MSc.",name:"Adriana",middleName:null,surname:"García-Alarcón",slug:"adriana-garcia-alarcon",fullName:"Adriana García-Alarcón",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428599",title:"MSc.",name:"Gabino",middleName:null,surname:"De La Rosa-Cruz",slug:"gabino-de-la-rosa-cruz",fullName:"Gabino De La Rosa-Cruz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428601",title:"MSc.",name:"Juan Carlos",middleName:null,surname:"Campuzano-Caballero",slug:"juan-carlos-campuzano-caballero",fullName:"Juan Carlos Campuzano-Caballero",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. 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Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. 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