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Denis Larrivee

University of Navarra

Dr. Denis Larrivee is a visiting scholar at the Mind and Brain Institute, University of Navarra Medical School, and Loyola University, Chicago. He has held professorships at Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School, Dr. Larrivee received the Association for Research in Vision and Ophthalmology's first-place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of seven books on clinical neuroscience and neurotechnology, and an editorial board member of the Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). He is also the lead author of more than one hundred papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences, Journal of Neuroscience, Frontiers Human Neuroscience, Journal of Religion and Mental Health, and IEEE Xplore. In 2018, he was a finalist for the international Joseph Ratzinger Expanded Reason award sponsored by the Francis Vittorio University of Madrid.

5books edited

7chapters authored

Latest work with IntechOpen by Denis Larrivee

Sleep is a fundamental physiological feature experienced by all known mammalian, and most non-mammalian, species. Underscoring its importance is the wide array of neural and cellular processes that have evolved to govern when and how it occurs, its duration, sequence of phases, and the influence it exerts on numerous other brain functions. This book takes up the growing prevalence of sleep disorders affecting these processes and the panorama of pharmaceutical tools that have evolved for their medical care. Its wide-ranging discussion promises not only recent updates on their clinical management but a contemporary window into sleep’s cross-cutting relevance for the many neurological dysfunctions now known to associate with sleep disturbances.

Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

Edited by Denis Larrivee

Books edited

Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice

Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice

Edited by Denis Larrivee

Redirecting Alzheimer Strategy

Redirecting Alzheimer Strategy

Edited by Denis Larrivee

Neuroethics in Principle and Praxis

Neuroethics in Principle and Praxis

Edited by Denis Larrivee

Evolving BCI Therapy

Evolving BCI Therapy

Edited by Denis Larrivee

Chapters authored

Brain Dynamics and Plastic Deformation of Self Circuitries in the Dementia Patient

By Denis Larrivee

Despite improved medical care that has resulted in greatly extended life expectancies, significant increases in numbers of individuals suffering age related cognitive defects is expected, making the improved understanding of normal and pathological aging an important priority. Current studies indicating that brain activity requires a dynamical architecture to preserve functional order in the face of persistent and extraneous activity suggests that cognitive impairments are likely to be closely linked to dysfunctional dynamical activity of brain systems. Cognitive impairments such as those introduced by Alzheimer’s dementia (AD), that affect fundamental operational constructs like the self, are thus likely to implicate global dynamics that oversee whole brain operation. This paper explores plastic events associated with dynamical elements used in the normal construction of the self percept and the etiology of their deconstruction in the course of AD. It is proposed that the evolution of the disease involves the increasing impairment of a global dynamical operation that is normally engaged in forming a stable and coherent self image needed to flexibly engage task related, motor plans and effectors.

Part of the book: Neuroplasticity

Introductory Chapter: Multilevel Representational Content in BCI Therapy - Extending Syntactic and Semantic Architectures

By Denis Larrivee

Part of the book: Evolving BCI Therapy

Introductory Chapter: Reconciling Neurobioethics through Nature’s Lens - Metaphysical Determinants of Subjectivity

By Denis Larrivee

Part of the book: Neuroethics in Principle and Praxis

Introductory Chapter: Beyond Risk Alleles - Invoking Cognitive Lesions in Top-Down Strategic Analysis

By Denis Larrivee

Part of the book: Redirecting Alzheimer Strategy

Introductory Chapter: Neurostimulation and the Structural Basis of Brain Activity

By Denis Larrivee

Part of the book: Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice

Introductory Chapter: The Promise of Sleep Pharmacotherapy - Healing Systems Level Dysfunction

By Denis Larrivee

Part of the book: Sleep Medicine and the Evolution of Contemporary Sleep Pharmacotherapy

Resting-State fMRI Advances for Functional Brain Dynamics

By Denis Larrivee

The development of functional magnetic resonance imaging (fMRI) in quiescent brain imaging has revealed that even at rest, brain activity is highly structured, with voxel-to-voxel comparisons consistently demonstrating a suite of resting-state networks (RSNs). Since its initial use, resting-state fMRI (RS-fMRI) has undergone a renaissance in methodological and interpretive advances that have expanded this functional connectivity understanding of brain RSNs. RS-fMRI has benefitted from the technical developments in MRI such as parallel imaging, high-strength magnetic fields, and big data handling capacity, which have enhanced data acquisition speed, spatial resolution, and whole-brain data retrieval, respectively. It has also benefitted from analytical approaches that have yielded insight into RSN causal connectivity and topological features, now being applied to normal and disease states. Increasingly, these new interpretive methods seek to advance understanding of dynamic network changes that give rise to whole brain states and behavior. This review explores the technical outgrowth of RS-fMRI from fMRI and the use of these technical advances to underwrite the current analytical evolution directed toward understanding the role of RSN dynamics in brain functioning.

Part of the book: New Advances in Magnetic Resonance Imaging [Working title]

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