Salivary variables measured for caries risk assessment.
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
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Genetics has become an indispensable component of almost all research in modern biology and medicine. Human genetic variation is associated with many, if not all, human diseases and disabilities. Nowadays, studies investigating any biological process, from the molecular level to the population level, use the "genetic approach" to gain understanding of that process. This book contains many diverse chapters, dealing with human genetic diseases, methods to diagnose them, novel approaches to treat them and molecular approaches and concepts to understand them. Although this book does not give a comprehensive overview of human genetic diseases, I believe that the sixteen book chapters will be a valuable resource for researchers and students in different life and medical sciences.',isbn:null,printIsbn:"978-953-307-936-3",pdfIsbn:"978-953-51-6767-9",doi:"10.5772/904",price:119,priceEur:129,priceUsd:155,slug:"human-genetic-diseases",numberOfPages:300,isOpenForSubmission:!1,isInWos:1,hash:"ee05b56a8355255883a05d9e647f83f3",bookSignature:"Dijana Plaseska-Karanfilska",publishedDate:"October 3rd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/385.jpg",numberOfDownloads:51255,numberOfWosCitations:34,numberOfCrossrefCitations:10,numberOfDimensionsCitations:38,hasAltmetrics:0,numberOfTotalCitations:82,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 22nd 2010",dateEndSecondStepPublish:"December 20th 2010",dateEndThirdStepPublish:"April 26th 2011",dateEndFourthStepPublish:"May 26th 2011",dateEndFifthStepPublish:"July 25th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,editors:[{id:"64941",title:"Dr.",name:"Dijana",middleName:null,surname:"Plaseska-Karanfilska",slug:"dijana-plaseska-karanfilska",fullName:"Dijana Plaseska-Karanfilska",profilePictureURL:"https://mts.intechopen.com/storage/users/64941/images/1847_n.jpg",biography:"Dr. Dijana Plaseska-Karanfilska graduated from the Faculty of Medicine, University “St. Cyril and Methodius” in Skopje, Republic of Macedonia in 1987. 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During her professional career Dr. Plaseska-Karanfilska made a contribution to the molecular characterization of different monogenic diseases in Macedonia, such as hemoglobinopathies, cystic fibrosis, cystinuria, Fragile X syndrome, etc. She has been also involved in the research of different infectious diseases, such as HPV, HBV, HCV infections and molecular basis of several malignant diseases as well as forensic DNA identification. 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\r\n\tOrganic synthesis has always been one of the central topics of research for the scientific community in the academic laboratories and industrial world. Many striking journal articles and remarkable reviews and books have been published in the past year describing the practicability and applications of the subject demonstrating the importance of organic synthesis. In the present book, we will be putting together the topics in organic synthesis which may include but not limited to, (1) the basic terms and concepts, (2) various organic reactions including reduction, oxidation, addition, elimination, rearrangements, and cycloadditions, (3) Total Synthesis of Natural products, (4) transition metal catalysts, organocatalysts, enzymes and biotransformations, (5) applications in medicinal chemistry and drug design and development, (6) purification methods and characterization techniques, etc. To set a limit and to increase the scope of the book, author(s) are encouraged to send the chapters that include selected examples with practical applications and good yielding reactions reported within the past decade. Older topics with significant findings or their essence to prepare the foundation may be included in the chapter are welcomed as well.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:null,priceUsd:null,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"f3bbbd989d0896f142d317ccb8abcc35",bookSignature:"Dr. Prashant S Deore",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8807.jpg",keywords:"Natural Product Synthesis, Organic Reaction Mechanism, Stereoselective synthesis, Chirality, C-H Functionalization, Cross-Coupling Reactions, Heterogeneous Catalysis, Homogeneous Catalysis, Green Synthesis, Green Solvents and Reagents, Bioorganic synthesis, Click Chemistry",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 10th 2018",dateEndSecondStepPublish:"January 14th 2019",dateEndThirdStepPublish:"March 15th 2019",dateEndFourthStepPublish:"May 20th 2019",dateEndFifthStepPublish:"July 19th 2019",remainingDaysToSecondStep:"2 years",secondStepPassed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"251769",title:"Dr.",name:"Prashant",middleName:"S",surname:"Deore",slug:"prashant-deore",fullName:"Prashant Deore",profilePictureURL:"https://mts.intechopen.com/storage/users/251769/images/system/251769.png",biography:"Dr. Prashant S. Deore was born in India. He received a Master’s degree in organic chemistry from Pune University in 2007. In the same year, he qualified with the SET and CSIR-NET (JRF) and joined in the group of Prof. Narshinha P. Argade for the doctoral studies in National Chemical Laboratory, India. In 2014, he awarded with a Ph. D. in Chemistry and was a recipient of the 2nd prize in “2014 Eli Lilly and Company Asia Outstanding Thesis Awards”. In July 2014 he moved to Canada and joined as a postdoctoral researcher in the group of Prof. Richard Manderville at the University of Guelph, Canada. Presently, Dr. Deore is working on the collaborative project between the University of Guelph and Aterica health Inc., and providing consulting to the company. 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From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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A higher voltage leads to a higher efficiency and less loss as well as more transmission capacity of the line and extends the value of transmitted power over longer distances. High-voltage engineering is the science of planning, operating, and testing high-voltage electrical devices and designing the insulation coordination in order to ensure the reliable operation of the power network. Therefore, high-voltage engineering provides the access to electrical energy for consumers far away from power generation units. This branch of science develops and optimizes operating characteristics of internal and external insulators.
\nThe appearance of semiconductor valves and attractive aspects of direct current network have been led to the development of high-voltage DC transmission lines (HVDC). Some advantages of HVDC transmission systems are their high dynamic stability, ability to be connected to large DC renewable sources and DC micro-grids, etc. Thus, developing large load centers and restricting high-voltage installation places makes it possible to extend HVDC underground cable lines. This attracts the attention of high-voltage engineers to improve the characteristics of cable insulators and other DC equipment’s insulation.
\nAs the concerns about global warming, greenhouse gas emission, and recycling the artificial wastes have been growing recently, different industries are forced to produce recyclable devices with lower environmental consequences. High-voltage researchers have extensively investigated nanopolymer cable insulators and environment-friendly materials to replace existing insulation materials. Cross-linked polyethylene (XLPE) is a well-known high and ultrahigh voltage cable insulation with interesting features such as excellent electrical and mechanical characteristics, high reliability, and low cost. However, because of recycling difficulties and environmental pollution, high-voltage scientists are trying to replace XLPE by nanopolymers like polypropylene/inorganic nanocomposites. The nanocomposites have better thermal and electrical characteristics than XLPE. Of course, nanopolymer manufacturing technologies are progressing, and there are many challenges in this way with regard to interactions between temperature, electric field, space charge, and DC volume resistivity under multifield coupling. It is necessary to review polypropylene and polypropylene/inorganic nanocomposites, as well as the opportunities and challenges for using them in HVDC cable insulation.
\nAnother development in high-voltage engineering for environmental compatibility is realized through replacing insulation gas SF6 by environmentally friendly gas CF3I in gas-insulated stations (GISs) and high-voltage circuit breakers. SF6 is an inert and electronegative gas with an excellent insulation strength. When a high-voltage circuit breaker opens short current from the source, the contacts are separated, while SF6 fills contact gaps; the gas experiences severe arc discharge for extinguishing the electrical arc. After extinguishing, because of an extremely high temperature, a plasma channel is formed. The powerful gas attracts plasma energy to avoid circuit breaker destruction. However, for avoiding global warming due to greenhouse gases, CF3I is used, as an environmentally friendly gas. CF3I is a colorless and volatile gas, and because of high boiling point of pure CF3I liquid, it cannot be used as a dielectric substance. Therefore, CF3I mixed with CO2 or N2 offers a dielectric strength by 75–80% higher than that of SF6. Thus, extended researches have been performed to replace SF6 by CF3I (mixed with CO2 or N2) with different ratios, considering operating characteristics.
\nBecause the conductors of a high-voltage cable line are packed in a confined space, the resultant voltage gradient causes an intense electric field, which in turn leads to high capacitance. Therefore, the cable current flow contains significant capacitance component rather than inductive component; this results in higher voltage at downstream node. Due to equivalent capacitance and inductance, natural frequency of a high voltage cable can be excited by harmonic content of a transient impulse that leads to destructive overvoltage known as “resonance” phenomenon. Actually, when natural frequency of equivalent capacitance and inductance is equal to one of harmonic components of transient switching impulse waveform, the resonance occurs. Depending on equivalent circuit in the branch where resonance occurs, resonances are categorized into three groups, i.e., series, parallel, and compound. The series resonance leads to voltage drop across the resonating branch. A very large impedance appears across the parallel branch that can create destructive overvoltage by a flowing small leakage current. Therefore, designers must consider the resonance in the planning of the insulation coordination of the networks.
\nOne of the main challenges in designing and operating high and ultrahigh voltage transmission lines is the occurrence of short circuit that makes bulk transmitting lines out of service and can destabilize the overall network. The overvoltage caused by lightning or switching is one of the main reasons for short-circuit occurrence along transmission lines. Therefore, planning engineers perform appropriate insulation coordination for line insulators against this kind of overvoltages with considering voltage level and line characteristics. Nevertheless, pollution aggregation on the insulator surface decreases the electric withstand. The pollution can be formed by combined dust, humidity, and salt in industrial or coastal areas where maintenance intervals may be very long. Therefore, planning engineers must know environmental circumstances in addition to electrical characteristics of transmission lines. Of course, this problem can be solved by increasing insulation strength, using more compatible insulators and washing the line insulators periodically.
\nArtificial tests of manufactured products are necessary in industrial applications as well as scientific studies. High-voltage devices need testing in manufacturing process, before sale, laboratory, and quality control stages, after installation for ensuring safe transportation/installation and predetermined maintenances. High-voltage testing is performed under loading or artificial impulses such as switching or lightning waveforms. The loading tests are performed in order to detect capacitance discharge of dielectric or partial discharge and insulation resistance. The impulse tests are performed to determine insulation strength of an external insulator that is not considered sufficient. The external insulator is designed for outdoor usages at different distances from the ground or on top of another isolator as in porcelain cover of bushings, buses, and sectionalizing insulators. Therefore, testing voltage is applied to a device more than one time, and then, complete flashover probability is calculated. The insulation strength has a stochastic nature, so it can be evaluated by statistical approaches. Characteristics of testing waveforms must be determined in a way that actual conditions can be realized.
\nFrom the ancient time, dental caries has existed, even from the time when the only way to eat and drink was hunting and gathering. According to the World Health Organization, 60–90% of schoolchildren worldwide have experienced caries, with the disease being most prevalent in Asian and Latin American countries (WHO, 2008). Dental caries is a multifactor disease which appears when demineralization of the hard tissues of the teeth occurs by organic acids formed by bacteria in dental plaque through the anaerobic metabolism of sugars derived from the diet.
\nCalcium is lost from the tooth surface, and demineralization occurs only when sugars or other fermentable carbohydrates are ingested in which results fall in dental plaque pH caused by organic acids that increase the solubility of calcium hydroxyapatite in the dental hard tissues.
\nLifestyle or dental health habits are the factors that should be connected to dental diseases. Dietary and daily habits, familial and physiological well-being, socioeconomic status and lifestyle, awareness and education, and area where they live are the factors that should be taken into consideration when discussing oral health. The higher the socioeconomic status is, the more the people are exposed to the availability of junk foods and susceptible to its frequent consumption. Those from lower economic group and rural area are not as much exposed to such food habits, and they do not buy them because they are expensive for their pocket. Many adolescents fail to brush their teeth effectively and tend to consume cariogenic foods even though they have basic knowledge of dental health. Children who have caries eat snacks between meals, more than those children without dental caries do. The basic means of avoiding these primary public health measures are compiled with the use of topical fluorides and fluoridated water. When it comes to nutrition perspective, one of the main things is to have balanced diet and adherence to the dietary guidelines and the dietary reference intakes.
\nDental caries occurs due to the demineralization of enamel and dentin (the hard tissues of the teeth) by organic acids formed by bacteria in dental plaque through the anaerobic metabolism of sugars and other fermentable carbohydrates derived from the diet [1]. Organic acids increase the solubility of calcium hydroxyapatite in dental hard tissues, and demineralization process of the tooth surface occurs due to calcium loss.
\nTeeth are most susceptible to dental caries soon after they erupt, and therefore the peak ages for dental caries are 2–5 years for the deciduous dentition and early adolescence for the permanent dentition [2]. The age of adolescences is when permanent teeth begin to grow and get their full position in the dental arch. This is a crucial age for the development of several oral diseases. Dental caries, periodontal disease, and orthodontic problems such as overcrowding of the teeth or malocclusions are bringing changes and altering the facial profile and esthetic appearance.
\nCertain psychological factors like self-confidence and social outlook of the individuals can also be affected, and they can leave permanent effect on the psychology of the child if not appropriately treated.
\nNeglecting the general problems, the lack of awareness and expertise is one of the reasons that most of the children at this age face these problems. Since the treatment of dental disease is very expensive especially in low-income countries, it would exceed the available resources for health care. The large financial benefits of preventing dental diseases should be emphasized to countries where current disease levels are high [3].
\nIt is undisputable that the development of dental caries is a result of poor diet, and it has been observed in humans and animals that frequent and prolonged exposure to carbohydrates and sugars results in an appearance of dental caries. Important bacteria in the development of dental caries are Streptococcus mutans and Streptococcus sobrinus. These bacteria produce organic acids from food sugars and help bacterial colonization of the tooth surface. The bacteria attached to teeth in dental plaque, found as a thin film on the surface of the enamel, utilize mono- and disaccharides (e.g., glucose, fructose, and sucrose) to produce energy, and acid is the by-product of this metabolism.
\nConsequently, the acidity of dental plaque may decrease to a point where the demineralization of the tooth begins. Demineralization occurs at a low pH when the oral environment is undersaturated with mineral ions, relative to a tooth’s mineral content. The enamel crystal, which consists of carbonated apatite, is dissolved by organic acids (lactic and acetic) that are produced by the cellular action of plaque bacteria in the presence of dietary carbohydrates. The “white spot lesion” is the initial stage that occurs just below the enamel surface and produces a visual whitening of the tooth. At this stage of mineral loss, the lesion may not progress any further or could even regain minerals (i.e., remineralize) if the cariogenic environment diminishes. The prevention measures that can remineralize the initial carious lesion are as follows: decreasing the carbohydrate source to the bacteria, treating the tooth with fluoride, reducing the levels of cariogenic bacteria, or reducing the bacterial ability to produce acid.
\nThe initial lesion will continue to lose mineral if the procedure of disease suppression is not initiated and the acidic challenge is unabated. The progressive dissolution of enamel and loss of enamel surface structure eventually give rise to a frank carious lesion [4]. Sugary food products and their everyday consumptions exert our teeth. The reasons behind dental caries are the exposure to junk foods, colas, sweets, and other dietary products which are easy to access and abundantly available for children to consume. That is why dental caries is like a sort of non-transmittable and nonfatal sickness [5].
\nSome authors emphasize the importance of the dental biofilm and dietary sugars as essential primary etiological factors causing the appearance of the caries; moreover, one of them cannot cause caries in the absence of the other.
\nThe main direct impact of the diet is mediated through its effect on the pH of the dental biofilm. Foods high in fermentable carbohydrates (mainly sugars) cause a low biofilm pH, while foods high in proteins and fats favor a more neutral biofilm pH. High-protein foods increase the urea concentration of saliva, which can be converted by ureolytic bacteria to ammonia; this raises the biofilm pH and is associated with decreased caries risk. Dietary factors can have an indirect effect by modifying the composition and metabolic activity of dental biofilm.
\nThe major dietary factor affecting dental caries prevalence and progression is sucrose [6]. A low consumption example is from a study of the Hopewood House in Australia, conducted between 1947 and 1952. As a matter of fact, children living in this closely supervised environment consumed food that was virtually free of sugar and white flour products. Data collected from these children revealed an extremely low dental caries prevalence, compared to children attending other Australian schools [7].
\nHigh sugar consumption’s effect is best revealed from the report of the classic Vipeholm study [8]. This study examined three factors leading to these stages as follows: the timing of sugar ingestion, the effects of the frequency of sugar consumption, and finally the consistency of the sugar on dental caries rates. According to the results, the degree of the sugar’s consistency was more important than the addition of sugar to the diet and especially if it was consumed between meals, or products, which are sticky, in a form that stayed longer in the mouth such as toffees. These products have a bigger cariogenicity impact than foods that are eliminated quickly from the oral cavity. Therefore, frequent ingestion of foods such as hard candies and throat lozenges that contain fermentable carbohydrates can be extremely harmful to the teeth. The conclusions from this study, conducted a half century ago, are still well regarded today:
If sugar is taken with meals, then only a small caries increase is noted.
A marked increase in caries increment is shown if sugar is consumed as snacks between meals.
If you consume sticky candies containing sugar, then the caries activity will be at the highest form.
Caries activity may vary greatly among individuals.
By eliminating sugar-rich foods, caries activity will be declined.
The detrimental effects of sugar in causing tooth decay are shown in the two major studies of public health importance, and those are the classic Vipeholm study in Sweden and Hopewood House study in Australia. Children generally consume diets which are rich in sugar like sweets, candies, cakes, colas, etc. That is why a lot of awareness has been raised since this food has a negative effect on oral health, and that is the appearance of dental caries. Nowadays, the household food that we generally eat contains certain amounts of sugar. That is why these two studies are of huge public health importance when conducting preventive dental health programs especially in schools where the drawbacks of consuming such diet containing sugars can be addressed.
\nA direct relationship between dental caries incidence and sugar (carbohydrates) intake is indisputed. The caries will not be developed if there are no fermentable carbohydrates in the food [9].
\nFree sugars as defined by the World Health Organization present as monosaccharides and disaccharides added to food, and sugars are naturally present in honey, syrups, and fruit juices. Fermentable carbohydrates are free sugars, glucose polymers (syrups and maltodextrins), fermentable oligosaccharides, and highly refined starches. They are added to food in industrialized countries and are as acidogenic as sucrose. However, sucrose and starches today present as the main carbohydrates in modern society diet. Sucrose is the most cariogenic sugar which is a highly soluble substrate transformed into intracellular (IPS) and extracellular polysaccharides (EPS). It diffuses easily into the dental plaque accumulation and induces a lower pH [10]. Starch is a carbohydrate that can cause very small amounts of caries, unlike real sugar. It is found in fruits and vegetables and can be consumed raw or cooked. Starchy foods such as rice, potatoes, pasta, and bread have very low cariogenicity, and this is why they can cause less caries than sucrose. Starch can be sorted out to mono- and disaccharides and metabolized by bacteria, so it is retained on the teeth long enough to be hydrolyzed by salivary amylase.
\nSince the original Miller’s study, Stephan in both of his researches (1940, 1944) about the relationship between caries and sugar showed that fermentable carbohydrates can transform into acid in dental plaque. A direct relationship between caries incidence and the frequency of consumption of sweets was also presented [11], and these findings supported those of the Vipeholm study [12].
\nSucrose is freely diffusible in dental biofilm and metabolized by oral bacteria Streptococcus mutans [13]. Bacteria metabolize sucrose to soluble and insoluble extracellular polysaccharide glucan by enzyme glucosyltransferases (GTFs). Few mechanisms are involved in the role of extracellular glucans as the major caries associated factor. Glucan enables the bacteria to adhere firmly to the teeth [, 14], and in dental plaque, they contribute to the structural integrity of dental biofilms [15].
\nSeveral studies showed that the presence of insoluble glucan enhanced the demineralization potential of S. mutans. Glucan altered the diffusion properties of plaque and allowed deeper penetration of dietary carbohydrates [16, 17].
\nThere are several important and critical cariogenic factors to be considered when evaluating starch and caries relationship. They are the size and frequency of tooth exposure, the bioavailability of the starches, the microbial flora of dental plaque, the pH-lowering capacity of dental plaque, and the flow rate of saliva. Starchy foods with higher amounts of sucrose are as cariogenic as а sucrose. Some cooked and processed starches are dissolved by salivary amylase, and they release glucose and maltose metabolized by oral bacteria to acids. In Rugg-Gunn [18] study, the relationship between starches and dental caries was proved, and several conclusions were made. Rice, potatoes, bread, and cooked staple starchy foods have low cariogenicity in humans. Uncooked starch has low cariogenicity, while heat-treated starch induces lesser caries than sugars. Foods with cooked starch and higher amounts of sucrose are as cariogenic as similar quantities of sucrose.
\nFresh fruits contain various sugars and may be capable of causing caries under some conditions. They have low cariogenicity, while citrus fruits have not been associated with dental caries. Increased consumption of fresh fruit in the diet is decreasing the level of dental caries in a population [19]. Although excessive exposure to fructose may produce dental caries, fresh fruits are likely to be much less cariogenic than most sucrose-rich snack foods consumed by children. One hundred percent fruit juice has also been associated with caries, but the relationship is less clear. Children consuming more than 17 oz. 100% juice are more likely to have caries, than children consuming water or milk [20]. Conversely, in a cohort of low-income African-American children, 100% fruit juice was found to be protective of caries. The fact that 100% fruit juice contains about the same amount of sugar as the average sugar-sweetened beverages made it important to understand its role in caries [21]. Animal studies revealed that all fruits cause less caries than sucrose but dried fruits may potentially be more cariogenic since the drying process breaks down the cellular structure, releasing free sugars that tend to have a longer oral clearance.
\nFlavored drinks, especially aerated beverages like cola, have a much greater cariogenic potential due to high sugar content and regular consumption. Children are frequently offered with these drinks because of their high acceptance, low cost, and parent’s belief of being very nutritious [22]. Different campaigns and various forms of advertising by the media changed public health knowledge, and people started to become aware and understand about the bad effect of this kind of food.
\nMilk is most frequently consumed by schoolchildren. In milk а sugar named lactose is not fermented as the other sugars, so it is less cariogenic because the phosphor proteins inhibit enamel dissolution and the milk antibacterial factors may interfere with the oral microbial flora.
\nCheese can lead to protection against creating caries as it stimulates salivary flow and raises the calcium, phosphorus, and protein content of plaque.
\nThe sugar alcohols like sorbitol, mannitol, and xylitol are kind of sweeteners that are metabolized by bacteria at much slower rate than glucose or sucrose, which is not metabolized at all. According to certain clinical studies, xylitol chewing gum has the ability to reverse initial white spot lesions on teeth.
\nWhen dental decay happens there is high probability of losing a tooth. That leads to a reduced ability to eat a varied diet. It is in particular associated with a low consumption of fruits, vegetables and non-starch polysaccharides (NSP) in the persons diet [23]. NSP intakes of less than 10 g/day and fruits and vegetable intakes of less than 160 g/day have been reported in edentulous subjects. Therefore, tooth loss may impede the achievement of dietary goals related to the consumption of fruits, vegetables, and NSP. Tooth loss has also been associated with loss of enjoyment of food and confidence to socialize. So, basically, it is clear that dental diseases have a detrimental effect on the quality of life both in childhood and older age [24].
\nAn important issue for the appearance of dental caries in older children as well as infants is not only the total quantity but also the form of the carbohydrate as well as the frequency of consumption since the refined carbohydrates exert their effect in the appearance of dental caries by serving as a substrate for caries-producing streptococci, which as a small piece of it adheres to the teeth for almost an hour. In the case of sugars that are not in sticky form, a specified amount consumed at one time is likely to be less conducive to the formation of dental caries than the same amount consumed in small portions throughout the day. There is considerable evidence that between-meal snacks cause the development of dental caries. Foods that must be avoided between meals are the following: sugar, honey, corn syrup, candies, jellies, jams, sugared breakfast cereals, cookies, cakes, chewing gum, and sweetened beverages, including flavored kind of milks, carbonated drinks, sweetened fruit juices, and fruit or fruit-flavored drinks. Finally, eating frequency, particularly constant grazing or sipping of foods and beverages, is also caries promoting. In a recent study in a diverse sample of children aged 2 to 6 years, eating frequency was associated with severe early childhood caries [25].
\nReduction of dental caries can be achieved with the help of fluoride or in other words dietary fluoride drinking water, which also has rich sources. The ingested fluoride becomes incorporated into enamel during tooth formation and increases the resistance of the tooth to decay. However, the main protection from dietary fluoride is the localized intraoral effect. Fluoride promotes the remineralization of damaged enamel with resistant fluorapatite and also inhibits bacterial metabolism of sugars. As we can see, the benefits to the exposure of teeth to fluoride are therefore beneficial lifelong. It may be added to an optimum concentration of 1 mg/L as a caries preventive measure if natural water supplies are low in fluoride; Murray et al. [26] have reviewed the published data on the effect of water fluoridation on caries and have concluded that on average water fluoridation reduces dental caries by 50%. In a study of 5-year-old children, Carmichael et al. have demonstrated that water fluoridation is effective in reducing dental caries across social classes and, in terms of the number of teeth saved per child, the benefits are greatest in the lower social classes [27].
\nAccording to UK national surveys, it has been indicated that those from lower social classes have higher levels of dental diseases and poorer oral hygiene practice and are less likely to visit the dentist [28]. In these cases, dental caries is not eliminated even though the benefit of fluoride is reducing caries. Fluoride repairs the damage caused by acids produced by plaque bacteria but does not remove the cause of caries, i.e., dietary sugars. The process of prevention requires both a reduction in sugar intake as well as optimum exposure to fluoride. Very extensive and comprehensive research by the National Health Survey concluded that a preventive dentistry program is water fluoridation.
\nDietary advice by dental health professionals should be consistent and not conflict with the advices from other health professionals, based on the evidence in the various professional fields and based on the national dietary guidelines. The advices may be more readily accepted from the people when the oral healthcare professionals can make unequivocally clear that the advice benefits caries prevention. If not, the person may not understand why the dental professional interferes with his diet and not accept the advices. However, this does not dismiss the dental professional from also explaining the benefits for general health on limiting or reducing the intake of sugars. Under the premise that it benefits oral health, the dental health professional can make stronger restrictions than the general guidelines as long as they do not harm general health. Generally speaking a diet that is beneficial to both general and dental health is one that is low in free sugars, saturated fat, and salts, as well as high in fresh fruits, vegetables, nuts and seeds, and wholegrain carbohydrates with modest amounts of legumes, fish, poultry, and lean meat and plenty of fluids preferably water and milk and, thus, modest with sugar sweetened beverages [29].
\nThe teeth and oral mucosa are cleaned with the help of saliva, which is a mixed glandular secretion. Saliva by itself is consisted of three glands, and they are as follows: submandibular, sublingual, and finally the parotid. It also has hundreds of small glands inside the oral mucosa and submucosa as well as gingival cervical fluid.
\nThe maintenance of healthy teeth and oral tissues could be achieved only with the help of saliva’s presence. If there were a severe reduction of the saliva’s production, then there would be a very fast deterioration of oral health as well as the patient’s life. The results from such a condition could lead to eating difficulties like: swallowing difficulties, bad oral hygiene, dental caries that progresses very fast, mucosa’s burning sensation, difficulty in talking, wearing denture, oral infections like Candida, and ulceration of oral mucosa.
\nDry mouth is a problem, which appears in huge proportions. Xerostomia or in other words dry mouth is very common for people with Sjogren’s syndrome, as a result of radiotherapy in the head and neck in cancer treating and especially in the case of older generations when they are prescribed with drugs. The saliva’s role in oral health is huge especially taking into consideration the sicknesses that appear because of decreased quantity or quality of saliva. That is why it is very important to early diagnose and prevent this condition.
\nSaliva is considered as the most easily available diagnostic fluid for noninvasive collection and analysis because through it we can diagnose caries susceptibility, systemic, physiological, and pathological, and we can monitor the level of hormones, drugs, antibodies, microorganisms, and ions.
\nIn this research, we will try to present the main functions of saliva, the anatomy and histology of salivary glands, the physiology of saliva formation, the constituents of saliva, and the use of saliva as a diagnostic fluid, including its role in caries risk assessment.
\nSaliva has several functions which are very protective, but it has also other functions presented in Figure 1. Salivary function can be organized into five major categories that serve to maintain oral health and create an appropriate ecologic balance: (1) lubrication and protection, (2) buffering action and clearance, (3) maintenance of tooth integrity, (4) antibacterial activity, and (5) taste and digestion [30].
\nFunctions of saliva.
\nFigure 2 presents the changes in plaque pH following as a result of sucrose rinse. The graphs are named as Stephan’s curve according to the name of the scientist who was the first one who described it in 1944. By using antimony probe microelectrodes in a series of experiments, he also measured changes in plaque pH.
\nStephan’s curve illustrating the changes in plague pH over time following a sucrose rinse.
The unstimulated plaque pH in Figure 2 is approximately 6.7. After the process of sucrose rinse, the plaque pH within a few minutes is reduced to less than 5.0. When the enamel is below the critical pH 5.5, then there is demineralization of the enamel. For about 15–20 min, plaque pH stays below the critical pH and does return to normal for about 40 min. In the presence of saliva and other fluids that are supersaturated with the help of hydroxyapatite and fluorapatite, the enamel itself could be remineralized only when the plaque pH recovers to a level above the critical pH.
\nThe buffering capacity, the degree of access to saliva, the velocity of the salivary film, and the saliva’s urea content are the ones that determine the variation of the shape of Stephan’s curve among individuals and the rate of recovery of the pH plaque.
\nThe major buffer in stimulated saliva is the carbonic acid/bicarbonate system. As the bicarbonate ion concentration gets higher, also the buffering capacity of saliva increases.
\nNowadays for the study of bacteria, proteins, and genes, there are very high-level techniques where they apply saliva in order to spread out the field of oral diagnostics in the process of learning and understanding the oral diseases, systemic diseases, as well as metabolism. Saliva by itself presents an opportunity for the identification of biomarkers for the diseases like dental caries, periodontal diseases, and oral diseases, but all this should be easily done with careful collection and handling.
\nThere have been developed a series of caries risk assessment tests based on saliva’s measurements. These tests measure the capacity of salivary buffering and salivary mutans streptococci and lactobacilli. The increased risk of developing caries comes because of high levels of mutans streptococci, i.e., >105 colony-forming units (CFUs) per mL of saliva. Individuals with high levels of lactobacilli (>105 CFUs per mL saliva) are the ones who consume frequently carbohydrates, and because of that they have an increased risk of caries.
\nAs an answer to the question what is buffering capacity, one could answer that it is the host’s capability to neutralize reduction pH’s plaque constructed by acidogenic organisms. Useful caries indicators for monitoring, preventive measures, and profiling patient’s disease are the salivary tests.
\n\nTable 1 lists some salivary variables measured for caries risk assessment in dentistry, which are more used for measurement than the other types.
\nFluid/lubricant | \nIt coats hard and soft tissue. Helps to protect against mechanical, thermal, and chemical irritation and tooth wear. Assists smooth air flow, speech, and swallowing. | \n
Ion reservoir | \nSolution supersaturated with respect to tooth mineral facilitates remineralization of the teeth. Acidic proline-rich proteins and statherin in saliva inhibit spontaneous precipitation of calcium phosphate salts. | \n
Buffering action and clearance | \nHelps to neutralize plaque pH after eating, thus reducing time for demineralization. | \n
Mechanical function of cleaning the tooth surface | \nClears food and aids swallowing. | \n
Antimicrobial activity | \nSpecific (e.g., sIgA) and non-specific (e.g. lysozyme, lactoferrin, and myeloperoxidase) anti-microbial mechanisms help to control the oral microflora. | \n
Digestion | \nThe enzyme α-amylase is the most abundant salivary enzyme; it splits starchy foods into maltose, maltotriose, and dextrins. | \n
Protective remineralization (promoted by fluoride) | \nSaliva also inhibits caries by protective remineralization. This is promoted by fluoride ions in saliva. | \n
Salivary variables measured for caries risk assessment.
While either measuring unstimulated or stimulated saliva’s flow rates, we should bear in mind the conditions of saliva’s collection process. When measuring unstimulated flow, which is usually at rest, repeated measurements should be assessed during the same day as a result of circadian rhythm and also because chewing (mechanical) and citric acid (gustatory) produce different results.
\nThe best way of measuring unstimulated or stimulated saliva is using commercial kit. When it comes to buffering capacity of unstimulated saliva which is lower or stimulated saliva, they are very easily measured at the chairside. In order to do bacteriological tests as chewing dislodges the flora into the saliva, then the best way is to use paraffin wax-stimulated saliva samples. From stimulated saliva samples, you can culture mutans streptococci and lactobacilli. Their measurements could also be facilitated with the help of commercially available chairside tests. However, when it comes to fluoride, calcium, and phosphate biochemical measurement, then these must be done with the help of special laboratory facilities that are not available to practitioners.
\nAs an answer to the question what is unstimulated whole saliva, one could answer that it is the mouth’s secretion mixture with tastants or chewing in the absence of exogenous stimuli. It is composed of parotid, submandibular, and sublingual secretions as well as the minor mucous glands, but it also contains desquamated epithelial cells, gingival crevicular fluid, leucocytes (mainly from the gingival crevice), bacteria, and possibly food residues, blood, and viruses.
\nThe collection of saliva from the patient is done in that way that the patient spits out saliva in regular intervals of time without swallowing it, and there is another way when the patient keeps his or her head down and mouth just a bit open so that saliva can drip down from the mouth into a beaker during a time interval. However, one should bear in mind that when saliva is spit down, the number of desquamated epithelial cells as well as bacteria are increased. The difference between the secreted amount by the different salivary glands and the evaporated volumes is the measured flow rate. The unstimulated salivary flow rates in healthy individuals and the average value for whole saliva is about 0.3–0.4 mL/min. Patients say that they have dry mouth (xerostomia) only when saliva is almost completely absent. Objective evidence of hyposalivation is considered a flow rate of <0.1 mL/min.
\nDentists should also measure salivary flow as part of their regular examination so that when patients complain of dry mouth, they will have the tests. The usual problems are related to swallowing difficulty that often leads to individuals with very little saliva but without discomfort and others with saliva flow rates within the normal range who feel that their mouth is drowning in saliva.
\nStimulated saliva is produced in response to a mechanical, gustatory, olfactory, or pharmacological stimulus, contributing to around 40–50% of daily salivary production. Several studies of stimulated salivary flow rates have been done in healthy populations and show a wide variation among individuals. The salivary flow (SF) index is a parameter allowing stimulated and unstimulated saliva flow to be classified as normal, low, or very low (hyposalivation). In adults, normal total stimulated SF ranges 1–3 mL/min, and low ranges 0.7–1.0 mL/min, while hyposalivation is characterized by a stimulated SF <0.7 mL/min. Many factors influence the stimulated salivary flow rate which, for whole saliva, has an average maximum value of about 7 mL/min.
\nEating is a strong stimulus for the secretion of saliva by the major salivary glands. Large volumes of saliva are secreted before, during, and after eating via the gustatory-salivary reflex, masticatory-salivary reflex, olfactory-salivary reflex, and esophageal-salivary reflex. The action of chewing, in the absence of any taste, will stimulate salivation to a smaller degree than maximum gustatory stimulation with citric acid. Mastication also serves to mix the contents of the mouth, thus increasing slightly the distribution of the different types of saliva around the mouth. Mechanical stimulation of the fauces (the gag reflex) leads to increased salivation.
\nAcid is the most potent of the five basic taste stimuli, the other four being salty, bitter, sweet, and umami. A study performed with different concentrations of citric acid revealed that 5% citric acid stimulated an average maximum salivary flow rate of about 7 mL/min. The citric acid was continuously infused into the mouth, and the teeth were covered with a paraffin film to protect them against the acid. For a clinical evaluation of the residual secretory capacity in patients with hyposalivation, a 3% citric acid solution can be applied to the patient’s tongue at regular intervals so that the degree of stimulation is relatively standardized. If a gustatory stimulus is held in the mouth without movement, salivary flow decreases to nature of stimulus gland size, mechanical unilateral stimulation, gustatory vomiting, pharmacological olfaction, food intake smoking, and gag reflex.
\nDawes [31] has stimulated the flow of saliva alters its composition and noted that the rate of salivary flow increases the concentration of protein, sodium, chloride, and bicarbonate and decreases the concentration of magnesium and phosphorus. Perhaps of greatest importance is the increase in the concentration of bicarbonate, which increases progressively with the duration of stimulation. The increased concentration of bicarbonate diffuses into the plaque, neutralizes plaque acids, increases the pH of the plaque, and favors the remineralization of damaged enamel and dentin.
\nBuffer solutions are solutions that maintain an approximately constant pH when small amounts of either acid or base are added or when the solution is diluted. These solutions own the capacity of resisting changes of pH when either acids or alkalis are added to them. There are three possible buffer systems in saliva—the carbonic acid/bicarbonate system, the phosphate system, and the proteins.
\nBicarbonate is one of the most important systems in saliva, which is produced by dental plaque, and its concentration could be from less than 1 mmol/L in unstimulated parotid saliva to a very high flow rate of 60 mmol/L which is elicited by chewing gum thus having a bicarbonate concentration of about 15 mmol/L. The level of bicarbonate ions in unstimulated saliva is too low to be an effective buffer. For those who suffer from the gastroesophageal reflux disease, the bicarbonate in saliva will help them in the clearance process of acid from the esophagus.
\nThe carbonic acid/bicarbonate system is one of the components of the saliva that modifies the creation of caries. It does this by changing the environmental pH and possibly the virulence of bacteria that cause decay. Tanzer et al. [32] tasted the efficacy of a sodium bicarbonate-based dental power and paste with the addition of fluoride on dental caries and on Streptococcus sobrinus or Streptococcus mutans recoveries in rats. These authors observed that the caries reductions in these studies ranged from 42 to 50% in the rats treated with bicarbonate dentifrices when compared with rats treated with water [33, 34].
\nThe concentration of phosphate in non-stimulated saliva is about 5–6 mmol/L, compared to a level of about 1 mmol/L in plasma; there is still too little phosphate in saliva to act as a significant buffer. The pH of unstimulated saliva is less than the pK2 value of 7.2 for phosphate so that most of the phosphate is present as H2PO4\n− and cannot accept another hydrogen ion until the pH is close to 2.1, the pK1 for phosphate.
\nIn saliva’s plasma there is about one-thirtieth protein concentration as well as few amino acids with acidic or basic side chains which present an important buffering effect at the usual pH of the oral cavity.
\nWhen the bicarbonate concentration increases, the salivary pH increases too. Henderson and Hasselbalch give the equation of the relationship between the pH and the bicarbonate concentration, which is pH = pK + log[HCO3\n−]/[H2CO3], in which the pK (about 6.1) and [H2CO3] (about 1.2 mmol/L) are virtually independent of the flow rate. The latter is in equilibrium with the pCO2 which, in saliva, is about the same as that in the venous blood. If we try to measure the pH of saliva, then it is very obligative to avoid exposure of the saliva to the atmosphere because the pH will be artificially elevated and CO2 will be released. At very low flow rates, the pH of parotid saliva can be as low as 5.3, rising to 7.8 at very high flow rates. Because of the low bicarbonate concentration, patients with hyposalivation will have a low salivary buffering capacity and a low salivary pH (Figure 3).
\nThe effects of flow rate on the concentrations of some components of saliva.
The importance of salivary urea was acknowledged early in dental literature [35, 36]. The pH-raising effect of intraoral urea application was first described by Stefan [37]. This author found that in both in vivo and in vitro, urea could raise plaque pH up to pH 9 and that the addition of 40–50% urea to carbohydrates largely overcame the pH-lowering effect for up to 24 h. The value of salivary urea ranges from 2 to 6 mmol/L.
\nUrea possesses the capability to inhibit the metabolism and multiplication of bacteria in the saliva, which indirectly neutralizе the acids in the oral environment and maintain the salivary acidobasic balance due to its buffer capacity [37, 38].
\nLess aciduric oral bacteria (Streptococcus sanguinis and Streptococcus gordonii) associated with dental health have the ability for alkali generation by hydrolyzing urea or arginine to ammonia. Production of ammonia is a mechanism that influences the balance remineralization-demineralization of the tooth, maintains neutral pH in oral cavity, and prevents the appearance of a cariogenic microflora [39, 40].
\nUrea can be used as a constituent of chewing gums for neutralized acids. Imfeld [41] explored the effect of sugar-free chewing gums containing various amounts of urea on the pH recovery in dental plaque.
\nAfter rinsing the mouth with 10 or 50% (w/v) sucrose solution, the respondents chewed the gum with different content of urea (10, 20, 30 mg) for 10 min. Increased value of salivary or plaque pH was found in the first minutes of chewing, and the effect of urea continued and lasted over 10 min. The higher concentrations of urea in chewing gum resulted in a faster leveling of the pH. As a result, the highest values of pH in the examined groups were observed in cases where they were treated with chewing gum containing 30 mg urea. With the use of such chewing gum, the salivary pH value does not fall below the level which is risky for the occurrence of dental caries, and there is a positive effect of chewing on the salivary flow that also affects neutralizing the acids in saliva or plaque [42, 43]. For the purpose of demonstrating the effect it can have on unstimulated saliva, a mathematical model of the influence of salivary urea on dental plaque was constructed. Data from study indicated that urea present in unstimulated saliva has a significant effect on plaque pH by elevating and counteracting the fall of plaque pH in the fasting state. The correlation of higher salivary urea concentrations and low salivary caries activity was registered in patients with chronic renal disease. These patients, who have elevated salivary urea concentration, have a reduced incidence of dental caries [44].
\nSaliva contains a supersaturated solution of calcium and phosphate, which neutralizes acids. Some epidemiological studies have revealed that humans with relatively high Ca and P in their plaque experience correspondingly lower caries. Higher Ca concentration of plaque is associated with low caries incidence. The process of undersaturation of the saliva with respect to tooth mineral content is a result of decreasing total phosphate concentration at high flow rates which would be bad for the teeth.
\nHowever, if the flow rate increases, then the saliva’s pH increases together with the bicarbonate concentration, and therefore high pH is altered. In the proportions of four different phosphate species (H3PO4, H2PO4\n−, HPO4\n2−, and PO4\n3) together with the fall in total phosphate concentration, there is a fall in H2PO4\n− and a slight increase in HPO4\n2− but a dramatic increase in PO4\n3−, all as a result high pH. It is the PO4\n3− that is an important ionic species with respect to the solubility of tooth mineral. So, although the total level of phosphate falls with increasing flow rate, the concentration of PO4\n3− actually increases as much as 40-fold when flow rate increases from the unstimulated level to high flow rates. The three components (Ca2+, PO4\n3−, and OH−) increase with salivary flow if taking into consideration the components of the ion product determining the solubility of tooth mineral in saliva. The saliva is more effective in reducing demineralization and promoting remineralization of the teeth if the flow rate is higher as well as the potential for calculus formation.
\nIt can be concluded that tooth decay is a disease of great importance for general health. As a result, strategies to reduce the risk for dental caries are extremely important. The strategies may involve decreasing the growth or activity of bacteria especially S. mutans. To do so, people need to change their daily diet. Parents should advise children to avoid eating between meals, especially food containing carbohydrate.
\nDiet and oral microflora are connected to caries along with host factors such as salivary composition and flow.
\nDiet rich in fermentable carbohydrates is responsible for causing caries. Sucrose is one of the most cariogenic sugars, and glucose and fructose have also been shown to be less cariogenic. The cariogenic potential of carbohydrate-containing foods depends on their stickiness characteristics, frequency, and amount.
\nThe saliva with its components plays an important role in maintaining oral, especially dental, health. Saliva is a natural factor that protects against demineralization. Apart from the activity of human saliva in diluting, clearing, neutralizing, and buffering acids, it also reduces demineralization and enhances the remineralization process.
\nSaliva performs its mechanical cleaning and protective functions though several physical and biochemical mechanisms. Saliva has buffer capacity which neutralizes acids in the mouth. The carbonic acid/bicarbonate system is the most important buffer in stimulated saliva.
\nThe urea contributes to maintaining the acidobasic balance of saliva and thus affects the incidence of caries.
\nIntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
",metaTitle:"Retraction and Correction Policy",metaDescription:"Retraction and Correction Policy",metaKeywords:null,canonicalURL:"/page/retraction-and-correction-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\\n\\n1. RETRACTIONS
\\n\\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\\n\\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\\n\\nPublishing of a Retraction Notice will adhere to the following guidelines:
\\n\\n1.2. REMOVALS AND CANCELLATIONS
\\n\\n2. STATEMENTS OF CONCERN
\\n\\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\\n\\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\\n\\n3. CORRECTIONS
\\n\\nA Correction will be issued by the Academic Editor when:
\\n\\n3.1. ERRATUM
\\n\\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\\n\\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n3.2. CORRIGENDUM
\\n\\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\\n\\n4. FINAL REMARKS
\\n\\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\\n\\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\\n\\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\\n\\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\\n\\nPolicy last updated: 2017-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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