Factors triggering acute heart failure.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"3510",leadTitle:null,fullTitle:"Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications",title:"Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications",subtitle:null,reviewType:"peer-reviewed",abstract:"A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.",isbn:null,printIsbn:"978-953-51-0989-1",pdfIsbn:"978-953-51-7099-0",doi:"10.5772/50198",price:159,priceEur:175,priceUsd:205,slug:"evolution-of-the-molecular-biology-of-brain-tumors-and-the-therapeutic-implications",numberOfPages:650,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"55fec67e081aaf4092d93187b20ab6d1",bookSignature:"Terry Lichtor",publishedDate:"February 27th 2013",coverURL:"https://cdn.intechopen.com/books/images_new/3510.jpg",numberOfDownloads:47840,numberOfWosCitations:41,numberOfCrossrefCitations:21,numberOfCrossrefCitationsByBook:3,numberOfDimensionsCitations:57,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:119,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2012",dateEndSecondStepPublish:"May 4th 2012",dateEndThirdStepPublish:"August 8th 2012",dateEndFourthStepPublish:"November 6th 2012",dateEndFifthStepPublish:"December 6th 2012",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"37886",title:"Dr.",name:"Terry",middleName:null,surname:"Lichtor",slug:"terry-lichtor",fullName:"Terry Lichtor",profilePictureURL:"https://mts.intechopen.com/storage/users/37886/images/3428_n.jpg",biography:"Dr. Lichtor is a practicing neurosurgeon. He has a number of research interests, and his brain tumor work is largely focused on the development of a DNA vaccine for treatment of primary and metastatic intracerebral tumors. In particular Dr. Lichtor has shown that vaccines prepared by transfer of DNA from the tumor into a highly immunogenic cell line can encompass the array of tumor antigens that characterize the patient’s neoplasm. Poorly immunogenic tumor antigens, characteristic of malignant cells, can become strongly antigenic if they are expressed by highly immunogenic cells. The introduction of the vaccine directly into the tumor bed of animals with an intracerebral tumor stimulates a systemic cellular anti-tumor immune response associated with a prolongation of survival. It is hopeful that this vaccine strategy will be efficacious in the treatments of patients with brain tumors. Dr. Lichtor is a member of the neurosurgery faculty at Rush University Medical Center in Chicago, Illinois.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Rush University Medical Center",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1085",title:"Neuro-Oncology",slug:"neuro-oncology"}],chapters:[{id:"43049",title:"Brain Tumor Invasion and Angiogenesis",doi:"10.5772/52309",slug:"brain-tumor-invasion-and-angiogenesis",totalDownloads:1797,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:null,signatures:"Almos Klekner",downloadPdfUrl:"/chapter/pdf-download/43049",previewPdfUrl:"/chapter/pdf-preview/43049",authors:[{id:"155547",title:"Associate Prof.",name:"Almos",surname:"Klekner",slug:"almos-klekner",fullName:"Almos Klekner"}],corrections:null},{id:"42916",title:"Gliomas Biology: Angiogenesis and Invasion",doi:"10.5772/53487",slug:"gliomas-biology-angiogenesis-and-invasion",totalDownloads:2223,totalCrossrefCites:1,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Maria Caffo, Valeria Barresi, Gerardo Caruso, Giuseppe La Fata, Maria Angela Pino, Giuseppe Raudino, Concetta Alafaci and Francesco Tomasello",downloadPdfUrl:"/chapter/pdf-download/42916",previewPdfUrl:"/chapter/pdf-preview/42916",authors:[{id:"36309",title:"Dr.",name:"Gerardo",surname:"Caruso",slug:"gerardo-caruso",fullName:"Gerardo Caruso"},{id:"54267",title:"Prof.",name:"Mariella",surname:"Caffo",slug:"mariella-caffo",fullName:"Mariella Caffo"},{id:"54268",title:"Prof.",name:"Concetta",surname:"Alafaci",slug:"concetta-alafaci",fullName:"Concetta Alafaci"},{id:"60567",title:"Dr.",name:"Giuseppe",surname:"Raudino",slug:"giuseppe-raudino",fullName:"Giuseppe Raudino"},{id:"159267",title:"Dr.",name:"Francesca",surname:"Granata",slug:"francesca-granata",fullName:"Francesca Granata"},{id:"160023",title:"Prof.",name:"Valeria",surname:"Barresi",slug:"valeria-barresi",fullName:"Valeria Barresi"},{id:"160024",title:"Prof.",name:"Mario",surname:"Venza",slug:"mario-venza",fullName:"Mario Venza"}],corrections:null},{id:"42918",title:"Hypoxia, Angiogenesis and Mechanisms for Invasion of Malignant Gliomas",doi:"10.5772/53298",slug:"hypoxia-angiogenesis-and-mechanisms-for-invasion-of-malignant-gliomas",totalDownloads:2e3,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:null,signatures:"Paula Province, Corinne E. 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Despite major achievements in the treatment of chronic heart failure over the last decades, which led to marked improvement in long-term survival, outcomes of acute heart failure remain poor with 90-day rehospitalization and 1-year mortality rates reaching 10–30%. There is an unmet need for improving acute heart failure care, including critical care to patient’s outcome.
\nAcute heart failure (AHF) is a disease with high rehospitalization and mortality rates. Improving acute heart failure critical care is important.
\nAcute heart failure (AHF), also known as acute decompensated heart failure or cardiac failure, refers to rapid onset or worsening of symptoms and/or signs of heart failure (HF). It is a life-threatening medical problem requiring evaluation and management soon.
\nAHF may present as a first occurrence or as a consequence of acute decompensation of chronic HF. AHF may be caused by primary cardiac dysfunction or precipitated by extrinsic factors, often in patients with chronic HF.
\nAHF is a life-threatening medical problem; thus, rapid transfer to the nearest hospital is essential, which has a cardiology department and coronary care/intensive care unit (CCU/ICU). Early diagnosis and evaluating the etiology are important in AHF. Therefore, all patients with suspected AHF should have a diagnostic workup and appropriate pharmacological and nonpharmacological management should be started promptly and in parallel.
\nThe most frequent primary causes of AHF include ischemic, inflammatory, arrhythmia, and acute valve insufficiency. Decompensation of chronic HF can occur without known precipitant factors, but more often with one or more factors, such as infection, uncontrolled hypertension, rhythm disturbances, or nonadherence with drugs/diet (Table 1) [1]. Some of them leading to decompensation, which need to be treated/corrected urgently, include acute coronary syndromes (ACS), hypertensive emergency, severe arrhythmias, acute mechanical cause underlying AHF, or acute pulmonary embolism [1].
\nAcute coronary syndrome | \n
Arrhythmia (tachyarrhythmia and bradyarrhythmia) | \n
Excessive rise in blood pressure | \n
Nonadherence with diet intake or medications | \n
Toxic substances (alcohol, recreational drugs) | \n
Drugs (e.g., NSAID, corticosteroid, cardiotoxic chemotherapeutics) | \n
Exacerbation of chronic obstruction pulmonary disease | \n
Pulmonary embolism | \n
Surgery | \n
Stress | \n
Metabolic/hormonal derangements | \n
Cerebrovascular insult | \n
Acute mechanical cause | \n
Factors triggering acute heart failure.
Initial diagnosis of AHF should be based on a thorough history assessing symptoms, prior cardiovascular history, and potential cardiac and noncardiac precipitants. The physical examination of a patient with AHF typically presents with some combination of increased congestion and, less frequently, decreased peripheral perfusion, further confirmed by appropriate additional investigations such as image and laboratory assessment (with specific biomarkers).
\nPoorly controlled hypertension is one of the predictor factors of AHF and should be avoided. Hypotension is a dangerous sign of poor prognosis for patients with AHF. Unstable heart rate and rhythm are not only a cause of the AHF episode, but also increase the risk of unstable hemodynamic. Respiratory rate is often not as carefully assessed clinically as other vital signs, but may represent inadequate resolution of the initial episode of lung edema or a new event, such as a pulmonary embolus. Fever reflects the possibility of underlying infectious process, which can instigate AHF exacerbations. Oxygen saturation is also an important vital sign for HF patients and should be measured.
\nBody weight provides an important information of severity of fluid overload and response to therapy. It is easy to measure and should be obtained as early as possible. Urine output and daily input and output measures are provided in more detail, but many clinical practices appear to be more difficult.
\nJugular venous pressure (JVP) is a useful physical examination finding to monitor fluid status and response to therapy in the AHF patient. Elevation of the JVP suggests that there is persistent volume overload and need more diuresis. JVP will be influenced by significant tricuspid regurgitation, while the elicitation of hepatojugular reflux can augment the interpretation.
\nCardiac auscultation is very basic and an important skill to follow the presence and severity of extra heart sounds (S3 and S4) and murmurs. The appearance of an S3 is associated with elevated ventricular pressure and poor left ventricular function. The reduction in the intensity of mitral and tricuspid regurgitation murmurs are the sign of reduction of ventricular filling pressure and volume.
\nBreath sound examination can provide the signs of lung congestion or pleural effusion. It can also evaluate the possibility of an underlying pneumonia.
\nExtremities edema reflects the status of fluid overload, and extremities temperature reflects the distal perfusion. Both of them should be closely monitored to understand the severity of low cardiac output/fluid overload and the response to management.
\nB-type natriuretic peptide (BNP) and N-terminal-proBNP BNP (NT-proBNP)—plasma concentrations of BNP and NT-proBNP—are increased in the presence of elevated ventricular pressure and volume, and have been used to assist in the diagnosis of AHF. There is no absolute “diagnostic level” of these biomarkers for AHF; most use different ranges. For example, a BNP less than or equal to 100 pg/mL is strongly suggestive of nonheart failure etiology for the dyspnea, BNP greater than 400 pg/mL is strongly supportive of AHF and BNP 100–400 pg/mL is indeterminate. High BNP levels may be the result of factors other than HF (e.g., age, renal dysfunction, myocardial infarction, acute pulmonary embolism, and high output states such as cirrhosis), and some factors may cause lower BNP levels (e.g., obesity, within 1 hour of flash pulmonary edema, acute mitral regurgitation, and mitral stenosis) [2, 3, 4, 5, 6].
\nClinical classification can be based on physical examination to detect the presence of congestion (“wet” vs. “dry” if present vs. absent) and/or peripheral hypoperfusion (“cold” vs. “warm” if present vs. absent) [8, 9]. The combination of these options identifies four groups: warm and wet (well perfused and congested), cold and wet (hypoperfused and congested), cold and dry (hypoperfused without congestion), and warm and dry (compensated, well perfused without congestion). This classification may be helpful to guide therapy in the initial phase and carries prognostic information. The “cold and wet” groups have most poor prognosis and need urgent management [1, 8, 9] (Figure 1).
\nClassification and management of AHF.
The insertion of an arterial line in patients with AHF and cardiogenic shock was recommended. The arterial line allows for repetitive sampling of arterial blood gases, providing important information on oxygenation (PaO2), ventilation (PaCO2), acid-base balance, electrolytes, and lactate levels. The continuous measurement of arterial pressure allows for the appropriate titration of vasoactive medication.
\nThe central venous catheter enables the monitoring of central venous pressure and allows the safe and continuous administration of vasoactive drugs and inotropes in patients with AHF who require intensive treatment. Central venous oxygen saturation (ScvO2) can also be monitored with the central venous catheter. In combination with increased lactate levels and signs of organ dysfunction, ScvO2 < 60% indicates severe hypoperfusion and mandates further diagnostics and urgent treatment.
\nA pulmonary artery catheter (PAC) may be considered in patients with hypotension and hypoperfusion to evaluate the volume status and cardiac output. However, the use of a PAC did not improve the survival and was associated with more adverse events. Based on the imbalance between potential benefits and known risks, PAC should not routinely be used to monitor patients with AHF, but it can still be justified to use PAC in selected populations by experienced physicians. PAC is most appropriately used in critical patients who need rapid evaluation of vasoactive medications or fluid balance.
\nNoninvasive techniques are undergoing considerable development to avoid complications of invasive monitor. However, none can be currently recommended for routine clinical use. Invasive techniques such as the PAC and transpulmonary thermodilution remain the reference standard.
\nSeveral algorithms have been proposed to determine cardiac output based on determination of systolic area by analysis of the contour of the pulse wave. These signals are often obtained from an arterial line.
\nDigital photoplethysmography is a technique for continuous measurement of blood volume changes. Severe skin vasoconstriction, which is common in cardiogenic shock, impairs signal quality of blood pressure and is an important limitation of the technique. These monitors are not useful when arterial impedance is variable, such as with vasoconstrictor administration, unless given continuously and steady state has been reached. Digital photoplethysmography techniques do not appear to be sufficiently effective in assessing cardiac output in resuscitation patients with microcirculatory disorders, peripheral vasoconstriction, or high blood pressure lability.
\nTransthoracic electric bioimpedance is a noninvasive method for cardiac output measurement. Several hemodynamic parameters can be measured and calculated using the technique including flow (e.g., stroke volume/stroke index), resistance (e.g., systemic vascular resistance/index), contractility (e.g., cardiac power index, systolic time ratio, pre-ejection period, left ventricular ejection time, velocity index, acceleration index), and fluid (e.g., thoracic fluid content). Thoracic bioimpedance data may be useful in fluid management in patients with AHF, and the differentiation of cardiogenic from pulmonary causes of acute dyspnea. Bioimpedance might be useful for trend analysis, but the data should be interpreted cautiously, as the method is associated with limitations that may affect its accuracy (e.g., arrhythmias, mechanical ventilation, body motion, and factors that affect conductivity between the electrodes and the skin-like temperature and humidity).
\nThe first step in management of the patient with AHF is to address life-threatening issues. Patients with respiratory distress/failure or cardiogenic shock should be treated soon and be triaged to a location where immediate respiratory and cardiovascular support can be provided.
\nRespiratory failure is the most frequent life-threatening condition for patients with AHF. Immediate management includes oxygen supply and removal of overload fluid.
\nCardiogenic shock is defined as a hypotension (SBP < 90 mmHg) with signs of hypoperfusion (cold sweated extremities, oliguria, mental confusion, dizziness, narrow pulse pressure, etc.). Emergency management is necessary to improve organ perfusion by increasing cardiac output and blood pressure. After fluid challenge, pharmacologic management consists of positive inotropic agent and a vasopressor as needed. Positive inotropes agents and vasopressors used to treat acute heart failure are discussed below and listed in Table 2. However, rather than combining several inotropes, device therapy has to be considered when there is an inadequate response.
\nInotropes/vasopressors | \nDose | \nRecommended | \n
---|---|---|
Dobutamine (beta-1 adrenergic receptor agonist) | \n2–20 μg/kg/min | \nAlso a vasodilator, may increase the risk of arrhythmia and hypotension | \n
Dopamine (variable effects on different receptors at different dose) | \n3–5 μg/kg/min; inotropic (beta+) >5 μg/kg/min: (beta+), vasopressor (alpha+) | \nMay increase the risk of arrhythmia | \n
Milrinone (phosphodiesterase type III inhibitors) | \n25–75 μg/kg over 10–20 min (optional) 0.375–0.75 μg/kg/min | \nAlso a vasodilator not recommended in acutely worsened ischemic heart failure. Dose adjustment is required in the presence of renal insufficiency, hypotension, or arrhythmias. | \n
Enoximone (phosphodiesterase type III inhibitors) | \n0.5–1.0 mg/kg over 5–10 min (optional) 5–20 μg/kg/min | \nAlso a vasodilator similar as Milrinone | \n
Levosimendan (ATP-dependent potassium channel activator with myocardial calcium sensitizing effects and possible PDE III inhibitor effects) | \n12 μg/kg over 10 min (optional) 0.1 μg/kg/min, which can be decreased to 0.05 or increased to 0.2 μg/kg/min | \nAlso a vasodilator increases the risk of hypotension | \n
Norepinephrine (alpha agonist) | \n0.2–1.0 μg/kg/min | \nIncrease systemic vascular resistance and afterload | \n
Epinephrine (alpha and beta agonist) | \n0.05–0.5 μg/kg/min | \nIncrease the risk of arrhythmia | \n
Positive inotropes and/or vasopressors for acute heart failure.
The next step to identification of precipitants/causes leading to decompensation that needs urgent management, including ACS, hypertensive emergency, arrhythmia, acute mechanical cause underlying AHF, and pulmonary embolism [1].
\nUse of vasodilator therapy in patients with AHF is based upon hemodynamic response, since evidence on efficacy and safety of vasodilatory therapy in AHF is limited. The routine use of vasodilators does not improve outcomes, and should be avoided [30, 34, 35].
\nDigoxin is mostly indicated in patients with AHF and rapid ventricular rate. However, in patients with renal failure or other factors affecting digoxin metabolism (including other drugs and elderly), the maintenance dose should be adjusted and avoid overdose.
\nEvidence-based medication to reduce morbidity and mortality for patients with chronic HF includes an angiotensin-converting enzyme (ACE) inhibitor, angiotensin receptor blocker (ARB), or angiotensin receptor-neprilysin inhibitor (ARNI); a beta blocker; and a mineralocorticoid receptor antagonist (MRA). During an acute HF episode, management of these agents depends upon whether the patient was already receiving these medications and whether the patient has contraindications to therapy such as hemodynamic instability or acute kidney injury. Once the patient is stable, evidence-based therapies are carefully initiated, reinitiated, or titrated with arrangements for appropriate outpatient follow-up. In stable patients, ACE inhibitor, ARB, or ARNI and beta blocker therapy should be initiated prior to hospital discharge, and then MRA should be added as soon as possible. Ivabradine reduces the risk of hospitalization in patients with HF and can increase stroke volume and maintain cardiac output when heart rate slows down. Ivabradine may be considered to be used with dobutamine at the acute phase [36, 37].
\nManagement of patients with AHF is complex and highly specific to the individual. However, there are some common pitfalls:
\n\n
The first step in management of the patient with AHF is to address life-threatening issues. Patients with respiratory distress/failure or hemodynamic compromise should be treated soon.
Respiratory failure should be treated first; initial therapy includes supplemental oxygen and assisted ventilation. Patients with respiratory failure due to AHF who fail to improve with non invasive ventilation require endotracheal intubation for conventional mechanical ventilation.
Most patients will also have significant volume overload leading to the respiratory insufficiency; diuretics remain the most commonly administered agent for AHF. Rapid administration of intravenous loop diuretics is recommended for volume overload. Ultrafiltration should be performed if failed to improve under diuretics use.
Severe low cardiac output requires aggressive management of their shock to mitigate or prevent the related end organ damage. Positive inotropes agents and vasopressors are used to treat low cardiac output and hypotension. In cases of severe AHF, which is refractory to medical therapy, temporary circulatory support (TCS) can be utilized to improve end-organ perfusion.
The next step to identification of precipitants/causes leading to decompensation that needs urgent management, including acute coronary syndrome, hypertensive emergency, arrhythmia, and acute mechanical and pulmonary embolism.
Vasodilators may be required to correct elevated filling pressures. The routine use of vasodilators does not improve outcomes, and should be avoided.
Evidence-based medication to reduce morbidity and mortality for patients with chronic HF includes an angiotensin converting enzyme (ACE) inhibitor, angiotensin receptor blocker (ARB), or angiotensin receptor-neprilysin inhibitor (ARNI); a beta blocker; and a mineralocorticoid receptor antagonist (MRA). During an acute HF episode, management of these agents depends upon whether the patient was already receiving these medications and whether the patient has contraindications to therapy such as hemodynamic instability or acute kidney injury. Once the patient is stable, evidence-based therapies are carefully initiated.
None.
As the era of postmodernism gathers momentum, Education is facing a fundamental challenge, especially to all those involved in Early Childhood Education and Care (ECEC). The existing paradigm in ECEC which is mainly based on psychological theories of child development that have been dominant in ECEC in the liberal world for the past 60 years is now subject to deconstruction [1, 2]. Both the purpose and process of Education for young children are under critical scrutiny from socio-cultural theory which advocates a radical shift in the content and pedagogy in ECEC from one based on the ‘self’ of individualism rooted in liberal ideology to one based on social responsibility and social justice rooted in democratic principles. Postmodernism rejects the pursuit of the individualism which encourages individuals to fulfil private ends mainly through relationships regarded as instrumental. Instead, it seeks to respect individualistic identity and subjectivity both within, and responsive to, social contexts.
Recognition of the ‘social’ function of Education is not new. Dewey, an influential American educationalist, writing at the beginning of the last century, claimed that the social function of Education was
Challenging the
Enlightenment thinking of the eighteenth century was also contained in the work of the Swiss philosopher, Rousseau who is now regarded as an iconic figure in the history of ECEC. He was unquestionably a highly influential exponent of child-centred educational theory [7]. In his book, ’Emile’ [8], written in 1762, Rousseau took the view that the guiding principle of a child’s education should be an understanding of the child’s nature at each stage of development. This was in stark contrast to the prevailing thought in the eighteenth century based on religious dogma. Although Emile is not a blueprint for educating children
The emerging emphasis on the individual child during the Age of Modernity in Western countries was in sharp contrast to the prevailing thought in Eastern countries [9]. One Eastern tradition that was very influential (and still is) was Confucianism where the individual was located in a socially conservative context that was defined by role dominance. Everyone knew their place and behaved accordingly with deference practised by lower-status groups for generations. Criticism and challenges were severely discouraged and often punished. This is still the case in China. Postmodernist ideas regarding social justice will be strongly resisted.
Turning to more recent times in the West, as the world emerged from the devastation of WW2 some 80 years ago many countries were eager to embark on an ideological shift from one based on a rigidly conservative social order to one based on liberal principles where freedom of the individual was highly celebrated and cultivated. In the UK, successive governments during the 1960s initiated a significant programme of liberal reforms in Education as recommended by official reports such as the ‘Plowden Report’ [10], and Before five in Scotland [11]. These reports embraced child-centred education which was largely rooted in developmental psychological theory at that time. The work of the Swiss psychologist, Piaget was particularly influential. The curriculum and pedagogy in primary schools and pre-schools/classes were to be located in individual learning and development based on activity and experience with play central to ECEC. The social construction of the ‘developing child’ flourished in the latter part of the twentieth century [12] and is still evident today in national curriculum guidelines [13]. It is the application of these ideas to the education of young children that is the focus of the challenge from postmodernism.
The central ideas of postmodernism are not new. European philosophers have posthumously inspired contemporary thinkers such as the French philosopher Lyotard [14] to develop these ideas in recent times. It was the work of the German philosopher Nietzsche over 100 years ago that has informed contemporary postmodernist writers. He claimed that in the social world there are only interpretations and constructs of various individuals and groups. Facts and objective truths were Modernist concepts [1]. At the end of the nineteenth century, this social relativism was in stark contrast to the absolutism and truth of science. For example, whilst no one would dispute that a water molecule consists of two hydrogen atoms and one oxygen atom, the same thinking does not apply to social phenomena such as, for example, the existence of a deity. According to Nietzsche’s ideas, a religious deity is a psycho-social concept which, if challenged, can generate aggression in certain people with deep convictions. Given the supremacy of scientific and logical thinking during the lifetime of Nietzsche, it is not surprising that Nietzsche’s ideas were dismissed as the work of a lunatic.
In the middle of the twentieth century, the French philosopher and sociologist Foucault demonstrated how the exercise of inter-personal power using discourse can serve to perpetuate social divisions and inequality to sustain the dominant hegemony in any given society [15]. Foucault has focused our attention on how social differences are reproduced in the fields of gender, ethnicity, social class etc., and inspired writers on postmodernism to deconstruct and challenge existing social norms. Interest in the work of both Nietzsche and Foucault began to re-emerge in the latter part of the twentieth century and it is now widely accepted that both Nietzsche and Foucault are the founders of the postmodernist era. In contemporary times, Foucault’s ideas on discourse and power relations are now being applied to ECEC [16] in several countries.
One may wonder, however, why the appreciation and acceptance of postmodernism in European countries have only emerged over the past 30 years in disparate fields of human endeavour such as the Arts, Architecture, Literature and Philosophy but only more recently in Education [17]. Given that Education is a valued public service, fundamental re-alignment largely depends on the champions for reform having the ear of government. It happened in the UK in the 1960s and Sweden in the late 1990s where the newly elected social democratic government 1995 instigated a root and branch reform of the Swedish education system, especially in ECEC [18].
At the end of the twentieth century, the dominant debate in ECEC was the issue of ‘quality’ in early years settings following the publication of the ground-breaking research findings on the long-term effects of Project Head Start in the US [19]. The research showed that a quality pre-school experience was essential for long-term positive outcomes. Based on modernist thinking, an instrument for assessing quality in ECEC was constructed in the US [20] to help raise the quality in early years settings. This inspired Dahlberg and others [12] to advocate an alternative vision of a quality environment for young children based on postmodernist ideas. It was revolutionary.
Around the same time, new developments in the sociology of childhood were beginning to emerge. These ideas offered an awakening of social theory’s concern with childhood and underlined the importance of postmodernist ideas [21]. It was the work of Dahlberg et al, however, that inspired others to advocate the reform of ECEC based on postmodernist theory. In 2006, Robinson and Diaz, working in Australia, published a book on social justice in ECEC based on postmodernist and feminist post-structuralism offering a radically different approach to the education of young children [1].
This approach has emerged from postmodernist writers’ deconstruction of the current theoretical basis of ECEC, a basis which has focused on the application of developmental psychology to educational practice since the 1960s. It regarded
This theory maintains that the dominant influences on shaping children’s social attitudes and behaviour are socio-cultural. These influences are at work, often covertly, within the family, in ECEC institutions, schools and the wider society including various media and religious organisations. They work to shape children’s identity and subjectivity from the day they are born and serve to normalize and label children within categories that result in subordination for some and in dominance for others. The theory presents an inspirational challenge to Education to dislodge such normalizing processes recognizing in so doing will not be an easy option as existing entrench attitudes and constructs in society will be threatened.
Learning about the world has been the cornerstone of Education in schools and colleges throughout the Age of Modernity. Undoubtedly many generations have benefitted from their time spent in educational institutions often driven by the promise of personal improvement [23]. However, it cannot be claimed universally throughout the modern world where many young people have learned to assimilate existing hegemonies and to accept a subordinate sometimes dehumanizing role [24]. Furthermore, the social attitudes and behaviour shown by many adults even with the experience of ECEC in their formative years have been shown to be wanton in relation to the deep-seated problems now facing the whole world [25]. Concern for such problems as expanding inequality and dehumanization is now the main driver for educators to find a way to a more humane and fairer social order.
The overarching purpose, therefore, of embracing postmodern theory is to generate a commitment to a better world in which social responsibility is a dominant hallmark. Education has a key role to play in social reconstruction by redefining the social attitudes that are transmitted to our children. The process of this challenging transformation begins in early childhood as it is during this stage of the human lifespan that young children can assimilate a commitment to social justice. It is well established that children are very receptive to learning when they are young [26]; it is a period in the human lifespan when they acquire foundational social attitudes that often prevail into adulthood. It is a significant challenge for postmodern educators to help dislodge current norms in many countries and replace them with greater critical awareness, responsiveness, and a sense of responsibility. To do this not only requires a curriculum for children’s learning in ECEC which is rooted in social attitudes and behaviour but also a pedagogy that is arranged to help teachers and others engage sensitively with children in critical discourse and example [27]. A curriculum founded on postmodernist theory should encompass the following themes:
Awareness and reflection
Social responsiveness
Social responsibility
Social justice
The postmodernist theory implies that these themes should intersect in a matrix arrangement with other aspects of learning in most national ECEC curriculum guidelines, which contrasts with the linear arrangement common in such guidelines [13, 28]. This arrangement requires a more socially engaged and critical pedagogy than at present. If the curriculum refers to the ‘what’ of children’s learning, pedagogy refers to the ‘how’ children’s learning experiences should be planned and organized. The extent to which these social learning themes are given overt priority in the pedagogy deployed in ECEC settings often depends on the culture and prevailing ideology in each country. For example, in Western liberal countries such as the UK, considerable importance has been given to supporting children’s personal, social and emotional development [29]. However, in some Asian countries, such as Taiwan and Japan, socio-emotional learning in young children has traditionally been regarded as the responsibility of the family and not the kindergarten [30]. With the introduction of new curriculum guidelines in Taiwan, however, and the national ideological transformation now taking place in a liberal direction, kindergarten teachers are now expected to address such matters in a meaningful way as part of the daily routines of the kindergarten with a growing emphasis on play [28].
Awareness is a complex concept. It has at least two levels in social contexts as well as mindful awareness of oneself [31]. The first is the level of observation/noticing in both social and physical environments [32]. The second higher-order level concerns our knowledge and understanding [33, 34] which many would argue is central to the education process. In childhood, awareness at level one often becomes habitual unless children encounter someone or something that attracts their particular attention. For example, young children can display an awareness of others who differ from the norm in each culture such as skin colour. If a child’s curiosity gets triggered, she/he will stare continuously for a short time often embarrassing the person who is the focus of attention. An informed parent might then ask the child not to stare as it would be considered rude whilst some parents might try to explain the difference that the child finds curious thereby taking the child’s awareness to level two.
Another example of awareness at level one is how children learn to differentiate between private and public spaces. For example, how do children learn to behave somewhat differently when eating at home compared with eating in a restaurant? Again, an informed parent would offer the child an explanation at level two. A postmodernist approach to this learning would follow up the awareness with reflection such that the child understands that the consideration for ‘others’ is considered important.
This is also a complex issue as it often requires a response to social encounters which differ according to the context. Even from an early age, a child’s response to a parent will normally be quite different from a response to a stranger or friend. To respond appropriately in each situation (parent, sibling, friend, teacher, or stranger), the child has first to be aware of ‘the other’ then decide if, or how, to respond overtly or covertly [35]. Most of the literature in this field focusses on children with some form of social disability such as autism [36]. However, it is relevant to all children as even so-called ‘normal’ children are constantly called upon to respond to others.
As with other social issues, learning how to respond to others is culturally loaded. How adults, both parents and teachers, help children to engage with others is important and will play a large part in children’s responsiveness when they themselves become adults. A postmodernist approach would encourage not only children to be aware but to reflect critically on their social encounters and respond to others, especially when in need or difficulty. ‘Passing-by on the other side of the road’ would not be encouraged.
This level of responsiveness requires children to apply their socio-emotional learning in their response to others.
Yet another situation that requires a response is in learning to take turns in a context in which other children wish to participate, examples being in children’s games [38] and the use of other equipment in the kindergarten. Here again, it is crucial that teachers and others help children to understand why this social skill of taking turns is important. Failure to do so allows selfish behaviour to become embedded in day-to-day social interactions.
Responsiveness in some children can also involve anti-social behaviour. During the first few weeks of arriving at a kindergarten, some children may respond to a perceived threat from another child by biting the other child. Helping the child to understand that such behaviour is unacceptable and requires the child to learn how to regulate their emotions. Involvement of the parents of a child displaying such behaviour is essential but requires sensitive social skills on the part of the teacher and childcare worker to address the problem [39].
Perhaps the most challenging aspect of helping children to learn appropriate social responsiveness, however, is to equip children with the skills and confidence to question the normalizing discourses that perpetuate social inequality [1]. How this is done is crucial as for some children there will be a clash between a critical perspective promoted in the kindergarten and the discourse prevalent in the family. In some Asian countries such as Taiwan and Japan, Confucianism is still highly influential [40]. The family is a very powerful social unit that both supports and controls its members sometimes to the detriment of individuals. Many parents expect their children to obey them at all times [41]. In such situations, the transmission of traditional cultural norms can be a significant impediment to the ECEC teacher tying to instill in children a mindset that can challenge such norms, norms that extend well into adulthood, especially in matters concerning gender [42]. For example, in Taiwan, a married couple is expected to spend the first day of the Lunar New Year with the family of the husband/father and then the second or subsequent day with the family of the wife/mother. This traditional cultural practice only serves to reinforce the greater esteem given to males in such countries [41]. A child with an awareness of social justice issues would propose to her/his parents that visiting families at this time of the year be alternated.
One of the first connections between ECEC and children’s learning about responsibility was made in the evaluation studies of the effectiveness of Project Heard Start. The researchers investigated whether participation in high-quality ECEC centres in the US would lead to greater social responsibility in adulthood. In these studies, ‘social responsibility’ was regarded as having four aspects: involvement in crime; formation of new family linkages; relation with the family of origin; and other personal and social characteristics. Whilst this perspective on social responsibility is consistent with that associated with the Age of Modernity it is interesting to reflect on the finding that successful persons (in terms of social responsibility) take control of their own destinies whereas the less successful feel that control is out of their hands [19].
A more recent approach to social responsibility and resonant with postmodernist ideas was articulated by Wray-Lake and Syversten [43]. They claimed that social responsibility is founded in democratic relationships with others where moral principles of care and justice motivate certain civic actions, a position also supported by Moss [44] who maintains that ECEC institutions should be places of democratic political practice. Reflecting on the prevalence of social responsibility in our contemporary world, especially with reference to the current virus pandemic, raises serious concerns that Education as is practiced in many liberal countries is deeply flawed. For many citizens, especially in such countries, to refuse vaccination and refuse to observe social restrictions in their daily lives in the name of ‘freedom of the individual’ is a moral rejection of social responsibility. It is an acute political issue. Humans live in a social world that requires mutual responsibility, not selfish individualism. Clearly, educators involved in ECEC in many countries now need to reconsider the importance they attach to their current practice of helping children to learn how to be responsible people. It requires a fundamental mental ‘reset’ based on postmodernist ideas in which ECEC has a crucial role to play.
A powerful way of achieving this is to involve children in group activities in which all the participants are interdependently involved. A successful outcome for a particular activity requires each child to fulfil her/his obligations to all the others. It has been shown that awareness of such obligations can become conscious in the first years of a child’s life as a moral issue [45].
In a previous publication, I outlined the essential features of what it means to pursue social justice, particularly in ECEC [46]. Settings that consciously pursue social justice education in a positive way will constantly require the teachers and child-care staff to instill in children the need for fairness, respect and opportunity. In so doing, social justice education
An enlightened teacher (and the principal/headteacher) committed to social justice would anticipate such reactions and place considerable importance and time in generating policy statements for the kindergarten followed up with extensive communication and negotiation with all the families of the children involved. This institutional response applies to all the areas of inequality such as gender identity, ethnicity, socio-economic status to name but three. It also requires an enlightened pedagogy that operates in the day-to-day routines of the kindergarten. The effects of such a pedagogy using judicious children’s literature were demonstrated in two preschools in Australia [47]. The findings of the research showed that the children involved learned greater respect for human diversity and differences.
In its broadest meaning, pedagogy addresses both the organization of the learning environment in terms of the layout and deployment of the available resources and the professional approach of the teachers/childcare workers in supporting children’s learning. In present-day practice in kindergartens/nurseries, the pedagogy is very often play-based and informal. Children can move about the playroom choosing activities and contact with other children at will [16]. The teacher/childcare worker will spend short periods of time with individual children and whole class groups in a supportive role influencing children’s learning in aspects of the defined curriculum.
A feature of a postmodernist pedagogy, however, is the priority given to children working together on various collaborative activities such as with ‘buddies’ or mentors and in both small and large groups. Central to such arrangements is the discourse that takes place during the activity. ‘Circle time’, which is often deployed in ECEC settings, is a particularly important opportunity for the teacher/childcare worker to illuminate social justice issues [48].
An example of such group activity that requires an interactive and reflective pedagogy is in the realm of Moving Image Education (MIE), which has been argued, enables us to search for new and unimagined pedagogies [49]. In MIE, the idea is to generate a short video on a topic democratically selected with the teacher and children. All the children would then search out visual images associated with the topic in magazines, picture books etc. The various inter-dependent roles in creating the video would be distributed by negotiation to the children involved such as the script ‘writers’, the actors, the camera operators, the prop designers, the editors, the producer, the music selectors and the video director. The teacher’s initial role would be to locate short films associated with the topic to show to the children and stimulate discussion and subsequent detailed planning. The value of such activity is in helping young children to learn about inter-dependency. The eventual production of the video depends on each child fulfilling her/his role in the production process.
A popular topic with children in ECEC is an imaginary journey to the moon [50]. The idea might seem complex for young children and beyond the normal pedagogic skills of teachers but with a suitably trained and skilled teacher it can be very effective in promoting children’s awareness, reflection, responsiveness, and responsibility as all the roles in the production of the video are inter-dependent. It is a highly motivating activity, and the children can feel a sense of pride when the video is shown to their parents. It is also claimed that MIE offers an opportunity for the realignment of the power relationships in groups of learners and teachers with consequences for learner and teacher identity [49].
Another important pedagogical practice that is open to a postmodernist approach is in the use of storybooks both by reading storybooks with a group of children and in children making their own picture books. The selection of appropriate storybooks is crucial as is the approach to the story used by the teacher. Reading storybooks with young children can enhance their prosocial behaviour [51] and can provide the opportunity to illustrate and illuminate social justice issues. For example, in Taiwan, the government has produced a series of colourful picture books with brief narratives for teachers and children in ECEC settings to explore the cultures of the various aboriginal tribes in Taiwan. On reading the narrative with the children the teacher will then engage the children in critical reflection which might be followed up with a member of a tribe visiting the kindergarten to extend the storybook narrative and/or a visit to a local aboriginal museum.
Storybooks can also be used to let children identify with the characters (sometimes animals) in the story. A multitude of social situations can become the subject of stories, particularly, where powerful emotions of happiness and sadness are involved. Storybooks can also illustrate everyday situations where power is deployed to control others. The use of puppets is another pedagogic practice that has high motivational involvement for young children which improves moral responsiveness to others [52].
A particular activity popular in Taiwan is for individual children to generate their own personal picturebook consisting of the child’s drawings, paintings, and pictures created over a period and clipped together. Each child will then, in turn, present her/his book to all their peers. By using a microphone each child will stand in front of the group to describe each page of her/his book and answer any queries/discussions that may arise from the other children. Again, it is highly motivating and a confidence booster for the children involved.
Role-play is also a popular pedagogic activity in ECEC settings where the children take turns to act a particular role. Here, again, how the teacher uses such situations is crucial. A postmodernist perspective would be for the teacher to activate children’s awareness of the context of the role-play then to help children reflect followed by highlighting the responsibilities of the various roles.
Another opportunity for group activity is in the preparation of snacks and other foods such as soup for the children to partake at snack time. Children learn to cooperate in the planning and the subsequent procedures. Clearing up after such activities underlines the importance of children’s social responsibility to others.
Essential to these pedagogic activities is the use and frequency of ‘circle time’ [48]. It is part of the daily routines of many ECEC settings though it has been found to be underdeveloped [53]. In a small group with the teacher and children sitting together in a circle, the teacher can raise key postmodernist ideas. Twice daily, there is an opportunity for children to share their recent experiences both inside the setting and in situations either at home or in the local area such as awareness of social events on the way to the kindergarten during the morning circle time or visits to places of interest with their family members. The teacher could then steer any discussion into a reflective mode by asking children what they found special about any event and/or what they found likeable/unlikeable. The afternoon circle time could focus on activities inside the setting. When appropriate, the teacher could explore social justice issues such as fairness and respect by asking children to share their views and feelings with everyone in the group in response to their experience of the activities available.
Once the children become confident to talk and discuss issues in circle time, a skilled teacher would be able to reflect on children’s experience by adopting a more critical dialogue informed by the recent work on critical pedagogy [27]. Such dialogue would initially be based on the teacher asking children to reflect and to propose better ways of organizing their activities. However, in some countries particularly in Asia, being critical is not encouraged in the culture. It can often be taken as a threat. There is little awareness of the need to differentiate criticism of ideas
The involvement of parents and other family members is vitally important if practices based on postmodernist ideas are to be successful [1]. Clearly, communication between the kindergarten and each child’s parents is essential. But communication
An important feature of this working relationship is the process of formulating the kindergarten’s policies not only on such matters as anti-social behaviour and provision for children with special educational needs but also on the profound social justice issues of gender, ethnicity, socio-economic status, and sexual identity. This process requires highly skilled professionals who can negotiate with and navigate through diverse social attitudes which requires the professional functions of ECEC teachers and childcare workers to be revisited [54].
Regular communication between the ECEC setting and the parents is essential to minimize any potential confrontation as the teachers help to raise children’s awareness and challenge entrenched social attitudes. This makes the political function of kindergartens explicit, though the exercise of that function should be done in a context of democratic negotiation [44]. Similarly, when a teacher provides feedback on each individual child to her/his parents, the feedback should be located in the child’s social and democratic context. Using ‘tests’ to assess each child’s abilities is counter-productive.
From the above, it is evident that a pedagogy based on postmodernist ideas places considerable demands on the professionalism of ECEC teachers and childcare workers. Current practice for the education and training of professionals in ECEC is inadequate to give teachers and childcare workers the skills now required. The education of ECEC professionals needs to be reconceptualised in the era of postmodernism [55]. Current constructions of professionalism leave few opportunities for ECEC teachers and others to engage in meaningful critiques of the
In the postmodernist era, a new approach to the education of ECEC professionals is required. An example of a 1-year postgraduate course at Linkoping University in Sweden is transforming how ECEC professionals are educated [58]. Based on a postmodernist curriculum framework this course trains ECEC professionals to help young children become more aware of their social environment through group-based activities, stories, and critical dialogue in order to equip children with resistance to the often-subconscious transmission of normative constructs on diversity and difference. It is now time to provide post-qualifying courses for childcare workers like that in Sweden and reform the professional course for ECEC teachers to provide early childhood education with critically reflective practitioners. In due course, consideration should be given to making such courses statutory for leaders (principals and headteachers) of kindergartens and nurseries in both the public and private sectors [59]. In so doing, the era of postmodernism will flourish.
This chapter has argued that the era of postmodernism requires us, humans, to think and act in a more sophisticated way than hitherto. The basis of such thought and corresponding action can begin when children are young and are receptive to learning new ways of thinking. Whilst the Age of Modernity has taught many of us to be rational and think logically, the emerging postmodernism requires our cognition to be more socially connected and less concerned with the pursuit of self-centred goals to the detriment of others.
In the postmodernist era, the potential role of ECEC professionals requires a more substantial recognition than at present. A major transformation is necessary. First and foremost, such a transformation requires a critical mass of educators to embrace postmodernist ideas and then to persuade governments of the need to allocate resources to initiate change at the national level. ECEC educators can become the instigators of a new social order which, above all else, embraces obligatory concern for others’ welfare, rights, fairness, and justice. Throughout the world, parents, ECEC professionals and governments need to be persuaded that a transformation of how young children are educated to become global citizens should be a priority. This chapter has addressed how this can be achieved by adopting a more critical pedagogy in ECEC.
The author wishes to place on record his appreciation to Su Yu-ling, the chairperson of the Department of Early Childhood Education, University of Taipei, Taiwan for her personal support and encouragement and Wang Hsiu-Ying, the secretary of the same department, for her technical advice in the preparation of the manuscript.
The author declares no conflict of interest.
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",coverUrl:"https://cdn.intechopen.com/series/covers/3.jpg",latestPublicationDate:"August 4th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"419588",title:"Ph.D.",name:"Sergio",middleName:"Alexandre",surname:"Gehrke",slug:"sergio-gehrke",fullName:"Sergio Gehrke",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038WgMKQA0/Profile_Picture_2022-06-02T11:44:20.jpg",biography:"Dr. Sergio Alexandre Gehrke is a doctorate holder in two fields. The first is a Ph.D. in Cellular and Molecular Biology from the Pontificia Catholic University, Porto Alegre, Brazil, in 2010 and the other is an International Ph.D. in Bioengineering from the Universidad Miguel Hernandez, Elche/Alicante, Spain, obtained in 2020. In 2018, he completed a postdoctoral fellowship in Materials Engineering in the NUCLEMAT of the Pontificia Catholic University, Porto Alegre, Brazil. He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. 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He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. Aljaser",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"423023",title:"Dr.",name:"Yosra",middleName:null,surname:"Soltan",slug:"yosra-soltan",fullName:"Yosra Soltan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"349788",title:"Dr.",name:"Florencia Nery",middleName:null,surname:"Sompie",slug:"florencia-nery-sompie",fullName:"Florencia Nery Sompie",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sam Ratulangi University",country:{name:"Indonesia"}}},{id:"428600",title:"MSc.",name:"Adriana",middleName:null,surname:"García-Alarcón",slug:"adriana-garcia-alarcon",fullName:"Adriana García-Alarcón",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428599",title:"MSc.",name:"Gabino",middleName:null,surname:"De La Rosa-Cruz",slug:"gabino-de-la-rosa-cruz",fullName:"Gabino De La Rosa-Cruz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"428601",title:"MSc.",name:"Juan Carlos",middleName:null,surname:"Campuzano-Caballero",slug:"juan-carlos-campuzano-caballero",fullName:"Juan Carlos Campuzano-Caballero",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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