The skin is the biggest structure of the body, and it plays a significant role in maintaining the unity of the body environment. The skin is important for the endurance of the organism as an outer coat for the thermal regulation and hydration preservation. With the intention of helping these significant utilities, the skin continually experiences regeneration and holds the capability to overhaul wound by repair and regeneration of several kinds of skin stem cells. Noteworthy, development has been accomplished throughout the recent times in the generation of engineered skin alternates which imitate human skin cells in vitro for replacement or modeling. Conversely, existing new skin alternatives do not reinstate completely the healthy skin anatomy and suffer from deficiency of natural supplements in skin covering, sebaceous glands, hair follicles, and sweat glands. Improvements in stem cell biology and skin morphogenesis show significant potentials to evidently advance the engineering of skin replacements which would preferably be vague from normal skin. This chapter reviews these developments in the in vivo and in vitro techniques of engineered and manufactured skin scaffold biomaterials.
Part of the book: Stem Cells in Clinical Practice and Tissue Engineering