Soil characteristics and soil moisture of a gradient from bare soil to vegetated site at grid points (a) K5 and (b) N5.
\\n\\n
IntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\\n\\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\\n\\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\\n\\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\\n\\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\\n\\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\\n\\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\\n\\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\\n\\nFeel free to share this news on social media and help us mark this memorable moment!
\\n\\n\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/237"}},components:[{type:"htmlEditorComponent",content:'
After years of being acknowledged as the world's leading publisher of Open Access books, today, we are proud to announce we’ve successfully launched a portfolio of Open Science journals covering rapidly expanding areas of interdisciplinary research.
\n\n\n\nIntechOpen was founded by scientists, for scientists, in order to make book publishing accessible around the globe. Over the last two decades, this has driven Open Access (OA) book publishing whilst levelling the playing field for global academics. Through our innovative publishing model and the support of the research community, we have now published over 5,700 Open Access books and are visited online by over three million academics every month. These researchers are increasingly working in broad technology-based subjects, driving multidisciplinary academic endeavours into human health, environment, and technology.
\n\nBy listening to our community, and in order to serve these rapidly growing areas which lie at the core of IntechOpen's expertise, we are launching a portfolio of Open Science journals:
\n\nAll three journals will publish under an Open Access model and embrace Open Science policies to help support the changing needs of academics in these fast-moving research areas. There will be direct links to preprint servers and data repositories, allowing full reproducibility and rapid dissemination of published papers to help accelerate the pace of research. Each journal has renowned Editors in Chief who will work alongside a global Editorial Board, delivering robust single-blind peer review. Supported by our internal editorial teams, this will ensure our authors will receive a quick, user-friendly, and personalised publishing experience.
\n\n"By launching our journals portfolio we are introducing new, dedicated homes for interdisciplinary technology-focused researchers to publish their work, whilst embracing Open Science and creating a unique global home for academics to disseminate their work. We are taking a leap toward Open Science continuing and expanding our fundamental commitment to openly sharing scientific research across the world, making it available for the benefit of all." Dr. Sara Uhac, IntechOpen CEO
\n\n"Our aim is to promote and create better science for a better world by increasing access to information and the latest scientific developments to all scientists, innovators, entrepreneurs and students and give them the opportunity to learn, observe and contribute to knowledge creation. Open Science promotes a swifter path from research to innovation to produce new products and services." Alex Lazinica, IntechOpen founder
\n\nIn conclusion, Natalia Reinic Babic, Head of Journal Publishing and Open Science at IntechOpen adds:
\n\n“On behalf of the journal team I’d like to thank all our Editors in Chief, Editorial Boards, internal supporting teams, and our scientific community for their continuous support in making this portfolio a reality - we couldn’t have done it without you! With your support in place, we are confident these journals will become as impactful and successful as our book publishing program and bring us closer to a more open (science) future.”
\n\nWe invite you to visit the journals homepage and learn more about the journal’s Editorial Boards, scope and vision as all three journals are now open for submissions.
\n\nFeel free to share this news on social media and help us mark this memorable moment!
\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"262",leadTitle:null,fullTitle:"Bioinformatics - Trends and Methodologies",title:"Bioinformatics",subtitle:"Trends and Methodologies",reviewType:"peer-reviewed",abstract:"Bioinformatics - Trends and Methodologies is a collection of different views on most recent topics and basic concepts in bioinformatics. 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\r\n\tSolvation is a physical process, solvation is the word meaning of separation of compounds depending on the selectivity of the solvent and solvent power whether the solvent green or organic solvent, solvation can act as a step in the crystallization and purification of the selected separated product, solvation technique divided into different type depending on the target, solvation techniques can be applied in water treatment for contaminations removals such as phenols and de-salination, petroleum refining, lube oil production and recycling, and paraffin wax separation and fractionation, purification and recycling, solvation depend on four main parameters: solvent to feed ratio, type of and characterization of the solvent, solvent power and temperature of the solvation, solvation technique can be evaluated with yield percentage and characterization of the separated fractions, solvation factors such as solubility and solvation energy can be studied theoretically by computational chemistry programs such as material studio, cosmo and gaussian.
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Solvent Extraction, Organic Solvent, Green Solvent, Crystallization, Separation, Wet Separation, Organic Solvent, Green Solvent, Separation, Extraction, Compound",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 11th 2019",dateEndSecondStepPublish:"March 16th 2020",dateEndThirdStepPublish:"May 15th 2020",dateEndFourthStepPublish:"August 3rd 2020",dateEndFifthStepPublish:"October 2nd 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"270842",title:"Dr.",name:"Fathi Samir",middleName:null,surname:"Soliman",slug:"fathi-samir-soliman",fullName:"Fathi Samir Soliman",profilePictureURL:"https://mts.intechopen.com/storage/users/270842/images/system/270842.png",biography:"Associate professor Dr. Fathi Samir Soliman is an expert in petroleum refinery, especially production, treatment and recycling of lube oils and paraffin waxes with catalytic conversion and solvent extraction. 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The Critical Zone is the near-surface part of the Earth’s crust, which sustains all terrestrial life [1]. During the last decade, a large number of landscape observatories have been implemented in order to study the Critical Zone and its behavior under global change condition. First Critical Zone Observatories (CZOs) were established in the USA; later, additional sites have been launched all over the world [2]. This paper introduces one of these CZOs in Germany with very unique conditions. The site represents a constructed watershed designed to analyze the ecological feedback mechanisms during the initial development of an ecosystem.
\nEcosystems have been shown in many studies to be utterly complex systems with many feedback mechanisms interacting between compartments [3, 4]. However, most of these studies were carried out in mature systems that had evolved over long time periods (e.g., [5, 6, 7]). Therefore, very little is known about how this complexity evolves over time and what role these feedbacks play during the development of ecosystems [8]. Most knowledge about early states of ecosystems was derived either from case studies after natural or anthropogenic disturbances (e.g., [9, 10, 11, 12, 13, 14]) or from chronosequence studies (e.g., [15, 16, 17, 18]).
\nIn recent years, landscape development and ecosystem development have been viewed as complex interacting processes leading to self-organization and state transitions [19, 20]. Within this context the concept of multiple stable states depending on environmental settings and on the possibility for catastrophic shifts in ecosystem composition and functioning, especially after disturbances or after passing ecological thresholds, was created [21, 22, 23, 24, 25, 26]. Unfortunately, most of the data supporting these concepts were recorded only post-event.
\nThe role of feedback mechanisms for the development of ecosystems and their functioning may differ depending on internal dynamics and external drivers. To better understand the underlying mechanisms, we developed a simple conceptual framework of how feedbacks between the major system components substrate, water, and biota interact and are affected by stochastic spatiotemporal drivers. Studies from arid environments indicate that ecosystems under water limitation may display alternative stable states, in which the interactions between abiotic and biotic processes determine whether or not a degraded state will prevail after disturbance [27]. The interaction between substrate and water is clearly driven by rainfall and evaporative demand, in which soil particles are mobilized on the surface (erosion) and within the substrate (soffusion) and subsequently immobilized during dry periods in which, for example, seals are transformed into physical surface crusts irreversibly changing runoff properties. Such interactions represent abiotic feedbacks that can either yield into self-stabilizing surface structure or a continuously changing erosive surface. At the same time, the formation of biological crusts and the germination of seeds will generate feedback processes that will affect substrate properties. In more humid and temperate climates, eventually feedback mechanisms between abiotic components and the biota will dominate the system, which was shown in many ecosystem studies.
\nTo study the role of feedbacks in state transitions during ecosystem development, we used 10-year time series of data from the constructed catchment Chicken Creek. This unique site offers the chance to observe state transitions in a relatively simple ecosystem from a very initial state with hardly any internal ecological memory [28] to more complex states.
\nThe Chicken Creek (“Hühnerwasser”) catchment is located within the lignite mining district of Lusatia in Northeastern Germany, about 150 km southeast from Berlin. It was constructed in 2004–2005 in the lignite mining area of Welzow-Süd, 30 km south of Cottbus, Germany (Figure 1) [29]. The region is characterized by temperate seasonal climate (563 mm mean annual precipitation, 8.9°C mean annual air temperature). The catchment was constructed by means of large mining techniques to establish a headwater for the Hühnerwasser, a small stream, which was destroyed by mining activities in the 1980s. This stream has to be restored during the reclamation process of the post-mining landscape. The site consists of two layers and has an inclination of 2.0–3.5% and a southeastern exposition. At the lowest part of the site, a basin was formed allowing the formation of small pond (originally about 60–70 m in diameter and 3 m depth in 2005/2006). Details of the construction process and of the substrates used are described [30].
\nLocation of the artificial catchment Chicken Creek.
The construction started with a 1–2-m-thick clay layer 8 (Figure 2a), which forms an aquiclude underlying the whole area of 60,000 m2 (400 × 150 m). The material was separated from the tertiary overburden layers by bucket wheel excavators and dumped by a stacker. The clay surface was then leveled by bulldozers – but not compacted, as this material tends to self-seal when considerable swelling occurs. Initially, the freshly dumped clay consisted of large aggregates, but these vanished after wetting and subsequent swelling. In this state, the clay layer had an extremely low permeability (ksat. ~10−9 m s−1). The clay layer was shaped into a shallow basin ascending from the center to the edges to form the subsurface boundaries of the catchment (Figure 2b). Belowground in the lower part of the catchment, additional clay dams were constructed on top of the clay layer perpendicular to the slope as a stabilization barrier to prevent the sandy substrate of the aquifer from sliding downhill on the clay layer and as a central groundwater discharge unit for the creation of an artificial spring for the reconstructed creek. A clay wall at the southern edge of the pond defines the lower boundary of the catchment and has a single defined outlet (Figure 2c).
\n(a) Schematic sketch of the major construction steps of the Chicken Creek catchment, (b) schematic cross and (c) longitudinal profile of the catchment (d) aerial image of the catchment showing the main morphological characteristics.
On top of this clay layer, 117,500 m3 of Pleistocene sandy material taken from the forefield of the open-cast mine (i.e., mainly C horizon substrates from the former landscape) was dumped to form the 2–3 m aquifer of the watershed (Figure 2a). The construction of this layer began in August 2004 with the eastern area of the hillside adjacent to the later hydrological catchment, followed by the central parts of the catchment during the next 2 months. The area of the catchment generally consists of three different sections which can be distinguished in terms of the overall construction procedure. The sandy material in the eastern part was dumped in August/September 2004. During the next construction phase in September/October 2004, the western part of the clay layer was completed and immediately covered with sandy substrate material. The central part of the site was left open as a “central trench” for a period of 7 months, before finally being filled in by bulldozers in May 2005 with substrate material from the eastern and western sections (Figure 2b). The surface level of the eastern part of the catchment was lowered in order to remove surface substrate that had been exposed to the atmosphere for more than 1 year and to restore the surface to an initial state. The surface layer was flattened and shaped into a shallow basin in order to define clear hydrological boundaries at the surface. As a final step, the surface of the sandy layer was homogenized, and the remaining surface structures from the construction were removed as good as possible.
\nThe hillslope-shaped site with defined boundary conditions and well-documented inner structures allows for studying ecosystem development ab initio at the catchment scale (Figure 2d). No amelioration measures, fertilization, or planting was carried out. Since 2005, the unrestricted, unmanaged development of the catchment was intensively monitored. Sensors and monitoring plots were originally oriented along a regular 20 × 20 m grid and were successively complemented with more structure and pattern-oriented instrumentation adapted to the development of the catchment (Figure 3). In total, 3 flumes in the main erosion gullies and 2 weirs equipped with automated sampling devices, 3 weather stations, 42 groundwater wells, 9–18 deposition samplers, 16 suction plates, 88 FDR probes, 40 pF meter, and 1 multiparameter probe in the pond are installed. Vegetation is surveyed every summer at four 1 × 1 m plots around each of the 119 grid points. More details on installed sensors and analytical methods are described [31, 32].
\nOverview of monitoring measurements at Chicken Creek catchment (aerial photo from 2013).
Initial soil sampling from all 120 grid points revealed some slight spatial variation of the Pleistocene material with respect to texture and chemical parameters reflecting the natural variability of these postglacial deposits. The western part of the catchment had more loamy sands, whereas in the eastern part, pure sands dominated. The vertical distribution was very homogenous. Due to the carbonate contents of the material (0.6–1.1%), pH values were uniformly between 7 and 8. Organic carbon (Corg.) content was very low (1–2 mg g−1).
\nTime series of meteorological, hydrological, biological, and soil data revealed a fast colonization of the catchment with invading vegetation that transformed the site from an initially abiotic system similar to arid systems to a state where abiotic/biotic feedback processes dominate [33, 34]. Aerial images of the catchment documented this rapid development and showed the increasing heterogeneity and the formation of surface structures and patterns (Figure 4). From 2010 woody plants increasingly formed clearly visible patches particularly in the eastern part of the catchment and in the surroundings of the pond. In 2015, more than 30 tree species were detected in the catchment.
\nAnnual aerial image mosaics of the catchments from 2005 to 2014.
Total vascular plant cover reached 58% in 2015, composed of over 170 plant species [35]. During the first 2–3 years, surface runoff, gully erosion, and sediment translocation were the dominating processes at the sparsely vegetated site that were triggered by single episodic events like heavy thunderstorms [32]. The slight textural variations in the initial substrates resulted in differences in morphological features of these surface structures, e.g., the frequency, depth, and width of erosion channels [36]. Surface runoff was promoted by the development of mechanical and biological surface crusts (BSC, [37]) sealing the soil surface. This sealing effect affected the catchment hydrology and runoff behavior far more than was predicted by hydrological models using mainly the textural composition of the substrate [38, 39]. Even though the establishment of BSC and its effects on infiltration and runoff is well described for arid and semiarid regions [40, 41, 42, 43, 44], the effect of BSC on hydraulic soil properties is discussed controversially, e.g., [45]. They conclude that the impact of BSC on water infiltration and conductivity is depending on surface properties of the crusts (roughness) as well as on specific crustal components. Due to regional climatic differences, BSC may either promote or inhibit infiltration and conductivity in soils. [46] showed the effects of different successional stages of soil crusts. They found that physical crusts, directly formed after a disturbance, lead to a homogenous and smooth soil surface and a promotion of runoff and soil erosion. The further development of BSC caused an increasing surface roughness (particularly well-developed BSC including mosses and lichens) and a decreasing potential for surface runoff. This is supported by soil moisture measurements in the topsoil along two gradients in the catchment showing highly significant increased soil moisture under BSC compared to bare soil (e.g., Table 1).
\nSoil characteristics and soil moisture of a gradient from bare soil to vegetated site at grid points (a) K5 and (b) N5.
Measuring period: 06/2010–11/2013; different letter indicates significant differences at p < 0.001.
This was most prominent for the mean and maximum values in both 3 and 10 cm soil depth, but not for minimum soil moisture. At both sites, the moss cover of the BSC was very high. At the same time, the gradients showed increased silt, clay, and Corg. contents below the BSC. These findings indicate that surface stability is probably one of the key factors for BSC establishment. Once established, they initially promoted surface runoff due to hydrophobicity and pore clogging [47]. During further development, the BSC were more and more covered by mosses, which provide a high potential for water storage and eventually for higher infiltration rates due to increasing surface roughness [48]. During recent years, most of the BSC areas were overgrown by higher vegetation. This development provides a good example for abiotic/biotic feedbacks and their spatiotemporal functioning.
\nOther examples for these kinds of feedback mechanisms are the spatial spreading of plant species within the catchment once they have established and the effect of surface structures like erosion gullies on plant species distribution. After the first years that were dominated by a disperse colonization of the site by prolific spreader species like
Spatial distribution and areal cover of
Despite the high surface runoff in the first years, an unconfined aquifer was formed above the clay layer across the hillslope (Figure 6). The groundwater table showed a seasonal and spatial variation but an overall increasing trend during the first 5 years.
\nGroundwater levels below surface at different grid points in the Chicken Creek catchment from 2005 to 2015.
In 2010, a very wet year with more than 900 mm precipitation compared to the long-term average of 563 mm, groundwater levels peaked and reached almost the soil surface in many parts of the catchment. Afterward, levels decreased again. The overall discharge from the catchment is controlled by the water level in the pond above the outlet weir. Until spring 2007, no discharge was recorded, due to the filling processes at the hillslope and the pond. Then, spiky, episodic discharge events were induced by rain, surface runoff, and snowmelt events (Figure 7).
\nDischarge from the catchment (at the pond outlet) and precipitation from 2005 to 2015 (values on top are annual sums for hydrological year, i.e., November 1–October 31).
Discharge also peaked in 2010 (max. 21 L s−1) and became more continuous afterward but still with long periods without discharge during summer. Since summer 2013 only very low discharge <1 L s−1 was recorded. Data from groundwater levels at the hillslope and water level in the pond that determines discharge showed no significant correlation during the first years (Figure 8).
\nCorrelation between groundwater levels and the water level in the pond for selected years.
With time, both the correlation between the coefficient and the slope of the linear regression increased. This indicated that discharge was not controlled by groundwater flow in the beginning but mainly by surface runoff from the hillslope. With development of the catchment, especially the buildup of groundwater and filling of the aquifer, base flow became likely the dominating source of discharge as is typical for many catchments [53]. Time series of R2 values and slope of the regression between the groundwater and pond level showed a similar trend as the cover of vascular plants in the catchment (Figure 9).
\nR2 and slope parameters of the regression groundwater vs. pond water levels and vascular plant cover in the catchment for the period 2006–2013 (* indicates significant correlation at p < 0.001).
These results indicate a transition of the hydrological regime from a surface runoff dominated discharge state to a state in which evapotranspiration and groundwater flow dominate the catchment response to rainfall.
\nOver the period of 10 years, we could define three phases of feedback controls on the catchment hydrology (Figure 10). In the very initial phase, these controls were mainly abiotic feedbacks between the initial substrate properties and rainfall events resulting in surface runoff, erosion, and gully formation (Figure 10a). These processes controlled discharge in the catchment and resulted in geomorphological changes of the hillslope surface. Surface runoff was promoted by the almost complete absence of vegetation and the sealing of surfaces due to the formation of various soil crusts. In this phase, substrate was transported from the hillslope downhill forming a sedimentation fan in the lower part above and in the pond. This resulted not only in a sorting of particle sizes within the fan but also in a residual accumulation of coarse-textured fragments at the soil surface uphill. Due to the various filling processes in the Pleistocene sediment body above the clay layer and in the pond, catchment discharge in this phase was very low and was dominated by single episodic events of surface runoff triggered by rainfall events or snowmelt.
\nFeedback processes controlling the hydrology of the Chicken Creek catchment in different phases of development (a – c).
After the rapid invasion and establishment of vascular plants, the second phase was mainly controlled by abiotic/biotic feedbacks (Figure 10b). As the vegetation cover increased, the soil surface was stabilized, and surface roughness increased. Groundwater levels increased and promoted plant growth especially within the gullies due to better water availability. Surface runoff and erosion were reduced and occurred only at episodic events after heavy rains or thunderstorms. After the pond was filled very quickly and the groundwater had increased to high levels, catchment discharge was high and more continuous in this phase.
\nIn the third phase, catchment hydrology was still controlled by abiotic/biotic feedback mechanism, but biotic components had an increasing impact (Figure 10c). The vegetation and especially the woody species clearly profited from the high groundwater table and allowed a strong growth. The BSC developed to a moss dominated state, which changed their role in hydrological functioning from reducing infiltration and surface runoff promotion to increasing water storage, infiltration, and higher soil moisture below the BSC. At the same time, the spatial distribution of BSC was reduced due to overgrowing by higher vascular plants. Both vegetation and BSC altered the soil properties of the uppermost topsoil by increasing the organic matter contents and by accumulation of surface litter, which resulted in better infiltration. Evapotranspiration increased both due to evaporation in periods with groundwater tables close to the surface and the increase of vegetation cover throughout the catchment, which in turn lowered the groundwater. Especially, the higher woody vegetation increased canopy interception. Some of the mainly inactive erosion gullies that were incised deep enough to drain groundwater contributed to a higher groundwater discharge in this phase. Surface runoff was almost completely stopped. Due to the elevated evapotranspiration demand, catchment discharge decreased again and was mainly fed by groundwater.
\nThese three phases of feedback controls on catchment hydrology have to be seen as an idealization of governing processes and the transition between them is gradual. The overall fast development within the catchment also increased spatial heterogeneity and diversity. Therefore, different parts and patches within the catchment may be in different phases at the same time or may remain in single phases over different periods. This behavior depends mainly on initial variations in substrate properties, on vegetation patterns formed and on spatial extent and intensity of the described feedback processes.
\nTen years of data from the Chicken Creek catchment showed a very rapid development of the site with an increasing complexity and heterogeneity. In the first years, stochastic signals like the initial substrate conditions and external drivers like extreme weather were the most important factors resulting in abiotic/abiotic feedback mechanisms shaping the morphology of the site and creating site diversity. Invading vegetation from the regional species pool (representing external ecological memory) over time increased the role of abiotic/biotic feedbacks as could be shown in many examples.
\nSites like Chicken Creek with known boundary conditions and structure information could help in disentangling feedback mechanisms between hydrological, pedogenic, biological, and geomorphological processes. Also, a more integrative view of succession and its drivers during the transition from initial, less complex systems to more mature ecosystems can be derived from such experimental sites developing from defined starting conditions [54, 55, 56]. Long-term time series of data are a key for a better understanding of these processes and the effects on ecosystem resilience [3, 57] and self-organization [19] as well as past and future effects of disturbance and global change [58].
\nThis study was part of the Transregional Collaborative Research Centre 38 (CRC/TR 38), which was financially supported by the Deutsche Forschungsgemeinschaft (DFG, Bonn). The monitoring was funded by the Brandenburg University of Technology (BTU) and the Brandenburg Ministry of Science, Research, and Culture (MWFK, Potsdam). The authors thank Vattenfall Europe Mining AG for providing the research site and the many helping hands at the BTU contributing to the field and lab work.
\nDiamond is widely known as the best thermally conductive material in nature, despite having no electrical conductivity when free of dopant impurities, its unique combination of lattice configuration and strong covalent electronic bonds result in a great capacity of heat conduction through phonons. This type of heat flow also occurs in some other insulating materials, in the form of waves and wave packets [1]. Combined with its low dielectric loss, low friction coefficient, transparency for a large range of light spectrum, high hardness, and chemical inertness, diamond is certainly an exceptional material choice [2]. This set of specific properties makes diamond an ideal candidate for use in thermal management tools, especially heat management deviecs [3]. Unfortunately, there are still limiting factors for this technology, as for example, limited size substrate and impurity control besides low availability of natural diamond. In recent years, the synthesis of diamond in the laboratory has been widely studied and improved and large-scale industrial facilities were developed around two major technologies of synthetic diamond production, known as high pressure and high temperature (HPHT) and chemical vapor deposition (CVD) [4, 5]. HPHT produces single crystalline synthetic gems similar to natural diamond. However, size availability and control of impurities, such as substitutional atoms of other elements and nondiamond carbon inclusions, are limitations of this method [6]. It is not uncommon to find HPHT diamond with a yellow to brown hue, characteristic of the absorption of C-defects or nitrogen impurities [7, 8]. On the other hand, CVD diamond synthesis takes advantage of the capability of producing polycrystalline films, which present closely the same properties of single crystal diamonds, with the possibility of deposition over nondiamond substrates and large deposition areas [9]. Additionally, this method provides better control over impurities and doping once it is based on the breakdown of hydrocarbon molecules inside a controlled atmosphere chamber [10]. Currently, the CVD diamond industry is evolving fast, with larger area of deposition and in the high growth rate for single- and polycrystalline CVD diamond, but many efforts are still being made in order to achieve larger areas, thickness, and quality uniformity [11]. The main prerequisite for CVD diamond films to be applied as heat sink components is that thicker freestanding films with good uniformity should be grown through a reasonable large area [12]. Thick films are easily laser cut and polished to nanometer level smoothness of the surface. However, an additional issue is that polycrystalline films present some fragility caused by grain boundaries, an additional issue to deal with [13, 14]. In high power or high frequency electronic applications, with the increasing switching speed of components, the heat generated consequently increases, leading to higher thermal power densities to dissipate which is also affected by the size reduction of electronic components, creating a growing demand of performance for heat management components [15]. However, good thermal conductivity is not the key by itself, to an adequate heat extraction system, a good homogenous contact between heat generating component and heat sink is crucial to rapidly conduct excess heat and suppress the formation of “hot spots” which critically decreases the performance and efficiency of electronic devices [13, 16].
Since the 1960s, studies have reported the use of diamond heat sink. In 1967, Swan mounted silicon avalanche diodes on diamond to achieve a continuous power density more than twice that found on copper [17]. That same year, Dyment and D’Asaro achieved continuous operation of GaAs junction lasers at a heat sink temperature of 2000 K using diamond heat sinks [18]. In 1968, Josenhans discussed diamond as an insulating heat sink for a series combination of IMPATT diodes [19]. In a subsequent study, Decker and Schorr demonstrated that the performance of IMPATT diodes is significantly improved using diamond heat sinks [20].
Between the 1970s and 1980s, more theoretical and experimental studies were published on diamond heat sinks. In 1972, Bernick calculated the steady-state temperature profile and thermal-spreading resistance for a uniform heat source on a semi-infinite type IIa-diamond heat sink [21]. Also in 1972, Russell and Thomson described a new technique for diamond heat sink fabrication based on diamond embedded in a copper rod [22]. In 1976, Hudson measured the thermal resistivity of diamond heat-sink bonds in the form of sputtered titanium and gold films at temperatures from 1.2 to 300 K [23]. In 1977, Burgemeister showed the practical improvements obtained in the use of diamonds as heat sinks comparing the thermal resistances of samples with various kinds of metal/diamond interface measured at about 400 K with a radiation detector [24]. In 1979, Ino et al. fabricated 80 GHz band silicon d.d.r. Impatt diodes with diamond heatsinks [25].
In the 1980s, the researches on diamond for electronics continued to be motivated by the use of diamond heat sink substrates for semiconductor device applications. In 1984, Leistner fabricated a high-power silicon pnn + impatt diodes by a simple diffusion process for operation on diamond heat sinks [26]. In 1988, Doting and Molenaar developed a mathematical model of a copper-supported diamond heat sink using an iterative scheme to compute the temperature and flux distribution at the diamond-copper boundary [27]. In 1990, Csanky reported a thermal model of double-drift IMPATT diodes on diamond heat sinks. This thermal model approximates the temperature-dependent thermal conductivities of Si and diamond (Type II) by means of simple empirical formulae [28].
In early 1990s, Ramesham et al. reported a novel method of fabrication of microchannels in synthetic polycrystalline diamond thin films for heat sinking applications [29]. In 1993, Beck et al. discussed the maximum temperatures in diamond heat spreaders using the surface element method [30]. Subsequently, the enhanced performance in GaAs TUNNETT diode oscillators above 100 GHz through diamond heat sinking and power combining was reported by Eisele and Haddad [31]. An interesting study on a novel cooling system for high-power laser-diode arrays using microchannels in CVD diamond was developed by Goodson et al. They proposed a system which uses a microchannel heat sink made of chemical-vapor-deposited diamond in order to reduce the array-to-coolant thermal resistance using a simple model for the combined conduction and convection problem [32]. In 1999, Bewley et al. demonstrated a high-temperature continuous-wave laser with diamond-pressure-bond heat sinking [33].
From the 2000s to the present, an increase in the number of publications related to diamond-based heat sinks has been observed. In 2003, Labudovic and Burka developed a three-dimensional finite element model of heat transfer and residual stress within high-power laser diodes and their heat sinks. The model addresses both p-side down and p-side up laser diodes mounted on a variety of commercially available gold plated diamond heat sinks [34]. In 2006, Jessen et al. reported the operation of AlGaN/GaN high-electron mobility transistors (HEMTs) atomically attached to a CVD diamond substrate. The results demonstrated the feasibility of producing GaN-based devices on polycrystalline CVD diamond substrates to maximize heat extraction from devices operating at high power [35]. In 2008, Schneider et al. reported a study on CVD polycrystalline diamond films for heat sink applications. The measurements of dielectric strength confirmed the potential of CVD diamond for thermal management in power electronics [36]. Still in 2008, Ekimov et al. reported the thermal conductivity of diamond composites sintered under high pressures [37]. In 2010, Parashchuk et al. reported that the use of diamond heat sinks extends the drive current range of pulsed diode bars by a factor of 2–3 and enables them to operate at more than one order of magnitude [38]. In 2018, Rogalin et al. discussed several applications of diamonds in high-power optics and electronics. The main features of diamond optics of heat sinks for high-power electronics were highlighted [3].
This chapter focuses on the application of CVD diamond in heat sinks. It covers three main aspects of this technology: (i) heat transfer in diamond, (ii) CVD diamond heat sinks, and (iii) free-standing CVD diamond wafers. The first explains the mechanisms of heat transfer in diamond and correlates to its properties. The second introduces the principles and concepts related to diamond heat sinks. Finally, we briefly introduce the prospects of development and processing of CVD diamond wafers.
Heat can be understood as the transfer of some quantity of movement between particles, whether inside a solid, liquid, or gas. This transfer can be mediated by different physical mechanisms, such as vibrational waves in the lattice of solids, known as phonons, free electrons, fluidic particles, and photons. Particularly for solids, the kinetics of heat transfer is in its majority caused by free electrons moving through the bulk material for conductors and by vibrational waves through the lattice for insulator compounds [1].
Diamond is a unique case when it comes to heat transfer, the nature of carbon covalent bonding of the structure results in a strong interaction between atoms. Carbon has four electrons in its valence band which in the fundamental energy state are distributed as
Upon those characteristics combined with light atomic mass, phonons inside this material lattice possess extremely high frequencies and acoustic velocities; moreover, phonon-phonon umklapp scattering1 around room temperature is low [40], this phonon scattering being the cause of thermal resistance [41].
In dielectric crystals, thermal conductivity reaches a maximum depending on temperature, and for diamond, this maximum is reached near 100 K for pure natural type IIa single crystals, increasing at ~T3 rate from lower temperatures until this peak and then decays as the temperature continues to rise since umklapp scattering begins to activate [42].
The general approach considers an analogy from gas conductivity as follows in Eq. (1) [43]:
where κ is thermal conductivity, C is the specific heat, V is phonon velocity, and Λ is the mean free path for phonons in the solid; the mean free path is a function of many factors, and scattering of phonons can be induced by other phonons, by the walls of the crystal, grain boundaries, chemical impurities, vacancies, dislocations, and isotopes [43].
The specific heat or heat capacity per unit mass C, and thermal diffusivity D can be related to the thermal conductivity through the material mass density ρ, described in Eq. (2):
Thermal diffusivity governs the transient response to heat input. It is often more easily measured than thermal conductivity, which governs steady-state response. Nontheless, thermal conductivity is the usually required property of interest in heat management applications [44].
With a rising temperature, thermal conductivity rises, but as there are more phonons to transport heat and as this population of phonons rises, the probability of phonon-phonon interactions also rises leading to higher probabilities of phonon decaying into other frequency phonons; this process will be dominant in any kind of diamond at sufficiently high T. For intermediate temperatures, scattering time τ is determined by impurities or other crystalline imperfections in diamond, such as isotope disorder. For temperatures below 100 K, only low frequency phonons are thermally excited; for this case, the dimensions of the sample are significantly more important as they determine τ [45], what explains for example, the anisotropy of κ in polycrystalline diamond films. In large, high quality diamond single crystals, phonon scattering that causes thermal resistance is predominantly caused by phonon-phonon and phonon isotope scattering [43].
In their work, Morelli et al. used an approach based on the Debye model to predict and analyze thermal conductivity of CVD diamond films produced by HFCVD and MPACVD. With this model and experimental data, they reported values ranging from 1200 to 1500 W m−1 K−1 at room temperature, reaching a peak at 220–250 K for HFCVD films, and ~1400 W m−1 K−1 for MPACVD film with a peak at 170 K [46].
Debye temperature indicates the temperature for which the occupation number of optical phonons becomes significant, indicating the crystal’s highest normal mode of vibration [1, 47]. In diamond, it is 2200 K [48] and this high Debye temperature is what gives diamond low thermal resistance and low expansion coefficient.
For CVD diamond, the success as a heat sink or heat spreader device is influenced by grain size and point defect scattering of the deposited film. In addition, it is also affected by the distance from the nucleation side of the films [49, 50, 51, 52].
The thermal properties are also influenced by the C-H bonding in the deposited layer because the process of thermal conductivity in diamond is controlled by phonon scattering rate on different kinds of defects, grain boundaries and phonon-phonon interactions. Since hydrogen decorates the defects, hydrogen concentration is a convenient indicator of imperfections in CVD diamond, as well as the isotopical nature of carbon [42]. The natural occurrence of carbon stable isotopes in diamond 12C and 13C is 98.9, and 1.1%, respectively; the enrichment of the isotopic 12C carbon up to 99.9% has showed to enhance the thermal conductivity of diamond at room temperature by nearly 50%, and calculations made from Callaway’s theoretical model shows that a 99.999% 12C isotope content should enable a thermal conductivity higher than 2000 W/mK [43, 53]. Table 1 demonstrates this variance with a comparison between common heat sink materials and natural and CVD diamond, emphasizing the variety of reported thermal conductivities for different kinds of CVD diamond films, depending on its production method and chemical nature.
Material | Thermal conductivity (W/mK) | Thermal expansion (10−6/K)* | Reference |
---|---|---|---|
Aluminum | 247 | 23.8 | [54] |
Copper | 398 | 16.8 | [54] |
Diamond (natural) | 2200 | 0.8–1.0 | [49] |
CVD diamond (SCD film) | 790–1800 (varying with C-H bonding) | 1.0–1.5 | [42] |
CVD diamond (MCD film) | 141 | [55] | |
551 | [56] | ||
950 (double layer, MPACVD) | [57] | ||
1000 | [58] | ||
700–2100 | [49] | ||
1000–1500 | [59] | ||
1200–1500 (HFCVD) and 1400 (MPACVD) | [46] | ||
1000–2000 (varying with film quality) | [60] | ||
CVD diamond (NCD film) | 80–800 | [51] | |
CVD diamond (UNCD film) | 7.8–26 | [56] |
Comparison between thermal conductivity and expansion coefficients of common heat sink materials, natural diamond and CVD diamond.
Values from Ref. [61].
Within this set of data, it is interesting to notice that some CVD diamond films with impaired quality by defects or smaller grain size present a still higher thermal conductivity at room temperature when compared to conventional metallic materials.
However, diamond is a homopolar solid. It is of primary importance to notice that thermal conductivity values change depending on which direction heat flows in CVD diamond films; this is due to a singular characteristic of this material. The CVD of diamond produces significantly high quality diamond thin films but the initial ~100 nm of grown material at the nucleation side of the film, also called coalescence layer, contains a higher density of grain boundaries due to smaller grain size what usually reduces thermal properties due to higher nondiamond carbon content; in addition, the columnar structure of films causes a sensible anisotropy of thermal conductivity, being higher in growth direction when compared to bulk crystals [12, 49, 55]. This difference between in-plane (κ∥) and perpendicular (κ⊥) to growth direction is usually in the range of 10%, but can reach up to 50% [57]. It is worth emphasizing that in diamond, for room temperature, almost all heat is conducted through phonons with ~10 μm mean free path; as a consequence, polycrystalline diamond films with average grain size smaller than ~20 μm have reduced thermal conductivity for room temperature and above [52].
One of the limiting factors in the use of CVD diamond as a heat transfer layer in the industry of high power electronic devices is the direct deposition over other composition devices, for example GaAs, due to its difference in thermal expansion coefficients. The thermal mismatch often causes an accommodation-related stress of the film-substrate system and in some cases can lead to complete detachment of deposited layer, a property strongly influenced by film quality and also grain size [62, 63]. This characteristic is what probably brought the practical use to the technologies applied nowadays, the deposition over a substrate chemically and structurally compatible with diamond properties and growth conditions, etching or mechanical removal of substrate material, and proper post deposition processing for matching application requirements, detailed in the subsequent section.
Laboratory-grown CVD diamond has been extensively studied, not only for its exceptional set of properties but also because the CVD method exceeds limiting barriers for exploration niches in science and industry [64, 65]. This technology is based on the metastability of the crystalline phase of carbon and diamond, under certain environmental conditions. By using a mixture of hydrocarbon gas in excess of hydrogen gas under pressures below of atmospheric, with an energy source for gas dissociation and subsequent reaction, carbon condensate to solid state enabling diamond crystals growth and then multiple growth nuclei coalescence form a continuous film over a surface [66].
As a brief summary of some applications that found in CVD technique a way to apply the properties of diamond where it was either not possible or excessively expensive, we have optical windows [67, 68], cutting tools [69, 70, 71], dental application tools [72, 73], conductivity and radiation sensors [74, 75, 76], and as a special matter for this chapter, heat sinking components, such as but not limited to transistor high power devices and high power laser diodes [32, 77].
Many deposition methods have been developed since its first report in academia by Derjaguin and Fedoseev in 1975, between the most used methods to grow diamond at low pressures from hydrocarbon gas hot filament, and microwave plasma activation techniques are the ones chosen for either cost efficiency and low complexity apparatus or higher quality films and better growth rates [2, 70].
The hot filament chemical vapor deposition (HFCVD) method came along with a discovery made by Matsumoto et al. in 1982 and is based on the heating of a refractory metal filament by appling an electrical current to about 2000°C; gases dissociate by heat and filament surface reactions. Indeed, there is an interesting chemical kinetics involving hydrogen dissociation in the HFCVD; besides its activation through heat irradiated from the filaments, its dissociation also occurs at the filament surface which acts like a catalyst for the adsorption of molecular hydrogen and desorption of atomic hydrogen. When using methane as a carbon source gas, methyl radicals (CH3) are assumed to be the major responsible specimens in the growth of CVD diamond films; the dissociation of methane into this radical is also promoted by heat and especially by atomic hydrogen chemical reactions in gas phase [66]. Figure 1 brings a schematic design of the growth environment for the HFCVD method, where growth and filament surface regions are highlighted.
HFCVD growth environment.
Microwave plasma-assisted chemical vapor deposition (MPACVD) was developed a year later by Kamo et al.; this technique uses a microwave radiation coupled inside a resonant cavity to activate the gas mixtures. Different geometries have been studied with the intention of reaching a closely confined plasma sphere, or in other cases, a better distributed plasma region that enables larger deposition areas [78, 79, 80]. This technology promotes the dissociation of molecular hydrogen at considerably higher rates, once the plasma region has a larger volume and free electrons accelerated by the electric field collide with hydrogen uniformly through this volume; this also occurs to methane, the heat generated by the microwave discharge keeps the generation of free electrons and also promotes gas dissociation [81]. Figure 2 brings a schematic design of the growth environment for the MPACVD method, where growth and plasma regions are highlighted.
MPACVD growth environment.
The growth mechanisms involved in diamond CVD are not fully understood, but they are accepted to be similar in both HFCVD and MPACVD, starting at the point which diamond, seeded particles at nondiamond substrates or single crystalline for homoepitaxial growth, suffer reactions at its surface when exposed to gas phase with atomic hydrogen, free atomic bonds appears at the surface by atomic hydrogen abstraction, this are known as dangling bonds. Methyl radicals subsequently bind to these free sites and then atomic hydrogen keeps removing hydrogen from CH3 molecules at the surface maintaining the sp3 coordination, what keeps the deposition continuously occurring. Atomic hydrogen also etches graphite in a higher rate than diamond, allowing that only diamond continues to grow [65, 81].
A special issue to deal with is film surface roughness, what is generally achieved through a variety of polishing procedures detailed in a posterior section of this chapter; some deposition methods were specially developed to overcome this problem. Depending on specific growth conditions, diamond can preferentially develop different film textures varying with which crystalline plane orientation is favored or not by those conditions [82, 83, 84]. Figure 3 shows idiomorphs or kinectic Wulff shapes, representations of individual crystallites more likely to grow depending on deposition conditions, that influence the growth velocities of {100} or {111} oriented faces.
Idiomorphs of diamond crystallite shapes as a function of facet velocity growth ratio α, which increases from 1 to 3 in a step of 0.25. The arrow indicates the fastest growth direction. From Ref. [
This relation of growth velocity is given by the as-known α parameter that can be expressed by Eq. (3):
where V100 is the velocity of {100} oriented facet growth and V111 is the velocity for {111} oriented facets [85]. Films with a {100} dominant morphology tend to have lower surface roughness when compared to {110} or {111} morphologies [83].
The epitaxy of diamond over iridium/YSZ (yttria-stabilized zirconia), iridium/SrTiO2, or iridium/MgO substrates has successfully been adopted as a method of obtaining a crystalline diamond oriented layer using bias enhanced nucleation (BEN) to grow oriented growth nuclei, and its posterior coalescence and thickening result in high quality smooth diamond layers. In this method, diamond is nucleated by the application of a negative bias for a short period of time. This potential accelerates carbon reactive species to substrate surface, forming sp3 and sp2 hybridization nuclei for growth; as soon as the bias is turned off, atomic hydrogen etches nondiamond phases and only the diamond oriented particles grow until they coalesce and form a continuous oriented film [86, 87, 88, 89, 90, 91].
To be used as a heat transport device, diamond films have to be free of the substrate material, also known as its free standing form. There are several methods in the literature, and this section will cover the most used for fabrication of CVD diamond thermal management tools.
In the fabrication of free-standing polycrystalline CVD diamond wafers, plasma-assisted methods are preferred once they promote higher growth rates, better film quality (i.e. lower metallic inclusions), and homogeneity [92, 93, 94] however, this kind of film is also produced by the hot filament method [95].
The practical approach shown in Figure 4 for the fabrication of CVD diamond heat sinks follows the procedures of: (1) growing diamond film over a compatible substrate, (2) removal of the substrate by mechanical procedures or chemical etching, (3) cutting and polishing of the CVD diamond top surface for reducing rough morphology in addition or not to the polishing of nucleation side to remove excessively small particles as well as the nondiamond carbon included in grain boundaries, and (4) metallization through PVD or brazing of metallic alloys or pure elements to mounting requirements, or metallization of CVD diamond surface layer by the inclusion of a dopant element, such as boron, until the metal/insulator transition is achieved.
Simplified scheme for production of CVD diamond heat sinks.
In a recent work, Dai et al. achieved the deposition of a double layered polycrystalline diamond in order to reduce the detrimental effect of nucleation layer without removing it, on the average value of κ by a two growth step process in which diamond is deposited over silicon; then the substrate material is etched chemically by a solution of HNO3 and HF, and the freestanding film is again exposed to growth environment with nucleation side up. However, presenting a slight decrease in κ for the temperature range of 250-400 K, their solution achieved a 950 ± 14 W m−1 K−1 thermal conductivity at room temperature [57]. This study shows the deposition method versatility and the still emerging technologies we can expect on the development and use of enhanced thermal management device fabrication.
The exceptional properties of CVD diamond, added to its conventional small thickness, make traditional machining and cutting methods difficult, expensive, slow, and lead to high probability of contamination at the worked surface. Lasers have been studied and applied as an inexpensive technique when compared to traditional machining, at high speed without significant surface contaminants [96, 97].
Conventionally, laser cutting of diamond is based on the transfer of energy between laser beam and workpiece; this increases the temperature at the surface of the cutting region and this heating effect can rise local temperature to above 1300°C (for a 1064 nm wavelength laser) creating an opaque zone by graphitization, resulting in a very high absorption of the incident luminous radiation. This process is practically independent of laser beam wavelength [98].
The laser cutting of diamond is affected by laser characteristics in one hand and workpiece characteristics in the other hand, for lasers wavelength, pulse energy, pulse length focal position, frequency and absorptivity at the incident radiationare the main parameters involved, the material contribution comes from chracteristics such as thermal diffusivity and presence of impurities [99]. Nd: YAG lasers at 1064 nm wavelength have less efficient coupling with diamond requiring a higher energy dose to achieve material removal by thermally dominant mechanisms. For ArF lasers with a 193 nm wavelength, more efficient optical coupling is achieved minimizing thermal load and reducing photon-affected zone to regions in close proximity to the point of beam incidence [96]. Excimer lasers have been described as the most suitable for diamond and diamond-like film processing due to higher absorption coefficient in these materials for UV phonons, as compared to visible and infrared radiation [100].
In addition to be a widely used method in diamond cutting, lasers are also an alternative in the smoothening of polycrystalline diamond films. The KrF excimer lasers (248 nm) show a high etching rate of 100 nm per pulse, with resulting roughness depending on laser pulse duration and incidence angle [101]. Watanabe et al. proposed a novel method for ultraprecision diamond polishing using UV lasers of wavelengths lower than 225 nm; their work describes a mechanism of carbon atom oxidation by UV irradiation and final mechanical removal as CO2 or CO [102].
Polycrystalline diamond growth via CVD processes tends to present a granular cone-shaped rough top surface morphology that may cause poor contact between heat generating device and diamond piece; this is also combined with the effect of reduced grain size and consequent increase of grain boundaries and nondiamond phases present in the nucleation region of the film severely decreasing thermal conductivity. Dielectric surface roughness can also aggravate the conductor roughness due to conformal nature of the metallization process. The thinning and polishing of the diamond piece is then of great importance to reduce the thermal conductivity of the affected region and smoothing of the film surface to promote better contact between pieces [12, 59].
Traditional abrasive polishing methods for natural diamond are not suitable for CVD diamond films because diamond exhibits nearly a factor of 600 of polishing rate difference depending on the direction it is being polished. In a polycrystalline film, the mix of present planes limits the material removal rate to the slowest direction. A method used for the efficient polishing of CVD diamond films is the thermochemical polishing, which consists in the friction of diamond workpiece with a heated iron disk; this takes advantage of the high solubility of carbon in pure iron, 170 mg cm−3 at eutetic temperature and also by high carbon diffusion rate [103, 104].
Another promising method called dynamic friction polishing can be applied to both single and polycrystalline diamond polishing due to its high efficiency and flexible environment (free of abrasives). Furthermore, it is performed at room temperature and open atmosphere. The use of this polishing method on CVD diamond thin films is sensitive to two factors: (i) the applied pressure during polishing, which in excess causes films to crack and (ii) lower pressures reduce material removal rate and time of polishing and long times induce higher thermal stress [14].
An alternative method for polishing is the planarization-by-filling, which is a method that offers a simple and conventional approach to the reduction of surface roughness without any kind of surface polishing. This technique consists basically in filling of the growth surface microcavities by adding a polymer, glass, diamond-filled glass, or similar material. The thin overlayer applied can also be polished to adequate thickness and expose some of the diamond surface [105].
The process of adding a metallic layer to CVD diamond films, metallization, are conducted by several different systems, most employing a refractory metal adhesion layer which when deposited under appropriate conditions, forms an interfacial refractory metal-carbide phase. Some metallization systems are based on processing noble metal surface chemistry or ion beam surface chemistry to provide a “near surface” chemically and structurally modified diamond suitable for non-refractory bonding metallurgies [59].
The need of a metal layer is dependent on application, diamond heat management devices are often metal coated for grounding, signal and power connections, and if that is the case, plating is preferred over thermal evaporation or sputtering because its simple and less costly [105].
The adhesion of the metallic layer is of paramount importance. The conductive metals like gold or copper are not suitable for direct deposition over CVD diamond due to diamond chemical inertness; then these metals platings require the application of other metal seed layers. Generally, these seed layers are of refractory metals due to their strong adhesion to diamond forming carbide complexes when exposed to annealing process at high temperatures (700–900°C). It is important to emphasize that the previously mentioned roughness of diamond can cause serious blistering of the plated metal if not made under proper conditions [105, 106].
Diamond and its laboratrial synthesis have been extensively studied and improved in the last decades. As diamond becomes more feasible as an engineering material, many industrial and technological uses begin to be economically attractive. This chapter aimed to bring an overview of current developments and remaining challenges on CVD diamond heat sink production and applications; CVD diamond polycrystalline films already reached all the properties of perfect IIa single crystal diamonds. Despite their first run in the market by the early 1990s, some technical issues still remain such as the rough surface obtained at regular growth rates, defects, and grain boundaries and intrinsic drawbacks on the CVD of diamond. Taking this into account, CVD diamond is still a better heat management material when compared to conventionally applied metals, and can be used in different levels of quality and physical properties to match specific application demands.
This research was supported by the São Paulo Research Foundation FAPESP (processes 12/15857-1 and 14/18139-8) and CAPES. M. A. Fraga acknowledges the support from CNPq (Process 421317/2018-3).
The authors declare that there are no conflicts of interest.
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\\n\\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
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\\n\\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
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\\n\\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
\\n"}]'},components:[{type:"htmlEditorComponent",content:"Our business values are based on those any scientist applies to their research. We have created a culture of respect and collaboration within a relaxed, friendly and progressive atmosphere, while maintaining academic rigour.
\n\nCo-founded by Alex Lazinica and Vedran Kordic: “We are passionate about the advancement of science. As Ph.D. researchers in Vienna, we found it difficult to access the scholarly research we needed. We created IntechOpen with the specific aim of putting the academic needs of the global research community before the business interests of publishers. Our Team is now a global one and includes highly-renowned scientists and publishers, as well as experts in disseminating your research.”
\n\nBut, one thing we have in common is -- we are all scientists at heart!
\n\nSara Uhac, COO
\n\nSara Uhac was appointed Managing Director of IntechOpen at the beginning of 2014. She directs and controls the company’s operations. Sara joined IntechOpen in 2010 as Head of Journal Publishing, a new strategically underdeveloped department at that time. After obtaining a Master's degree in Media Management, she completed her Ph.D. at the University of Lugano, Switzerland. She holds a BA in Financial Market Management from the Bocconi University in Milan, Italy, where she started her career in the American publishing house Condé Nast and further collaborated with the UK-based publishing company Time Out. Sara was awarded a professional degree in Publishing from Yale University (2012). She is a member of the professional branch association of "Publishers, Designers and Graphic Artists" at the Croatian Chamber of Commerce.
\n\nAdrian Assad De Marco
\n\nAdrian Assad De Marco joined the company as a Director in 2017. With his extensive experience in management, acquired while working for regional and global leaders, he took over direction and control of all the company's publishing processes. Adrian holds a degree in Economy and Management from the University of Zagreb, School of Economics, Croatia. A former sportsman, he continually strives to develop his skills through professional courses and specializations such as NLP (Neuro-linguistic programming).
\n\nDr Alex Lazinica
\n\nAlex Lazinica is co-founder and Board member of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his Ph.D. in Robotics at the Vienna University of Technology. There, he worked as a robotics researcher with the university's Intelligent Manufacturing Systems Group, as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and, most importantly, co-founded and built the International Journal of Advanced Robotic Systems, the world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career since it proved to be the pathway to the foundation of IntechOpen with its focus on addressing academic researchers’ needs. Alex personifies many of IntechOpen´s key values, including the commitment to developing mutual trust, openness, and a spirit of entrepreneurialism. Today, his focus is on defining the growth and development strategy for the company.
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Nevertheless, it continues to have challenging dimensions, such as its ongoing dependence upon the use of unclaimed bodies in many societies. These challenges are reminders that anatomy does not remain stationary.",book:{id:"5933",slug:"human-anatomy-reviews-and-medical-advances",title:"Human Anatomy",fullTitle:"Human Anatomy - Reviews and Medical Advances"},signatures:"David Gareth Jones",authors:[{id:"35851",title:"Prof.",name:"Gareth",middleName:null,surname:"Jones",slug:"gareth-jones",fullName:"Gareth Jones"}]},{id:"55203",doi:"10.5772/intechopen.68775",title:"Innovative Technologies for Medical Education",slug:"innovative-technologies-for-medical-education",totalDownloads:2124,totalCrossrefCites:3,totalDimensionsCites:4,abstract:"This chapter aims to assess the current practices of anatomy education technology and provides future directions for medical education. It begins by presenting a historical synopsis of the current paradigms for anatomy learning followed by listing their limitations. Then, it focuses on several innovative educational technologies, which have been introduced over the past years to enhance the learning. These include E-learning, mobile apps, and mixed reality. The chapter concludes by highlighting future directions and addressing the barriers to fully integrating the technologies in the medical curriculum. As new technologies continue to arise, this process-oriented understanding and outcome-based expectations of educational technology should be embraced. With this view, educational technology should be valued in terms of how well the technological process informs and facilitates learning, and the acquisition and maintenance of clinical expertise.",book:{id:"5933",slug:"human-anatomy-reviews-and-medical-advances",title:"Human Anatomy",fullTitle:"Human Anatomy - Reviews and Medical Advances"},signatures:"Pascal Fallavollita",authors:[{id:"85455",title:"Prof.",name:"Pascal",middleName:null,surname:"Fallavollita",slug:"pascal-fallavollita",fullName:"Pascal Fallavollita"}]},{id:"54586",doi:"10.5772/67897",title:"Human Brain Anatomy: Prospective, Microgravity, Hemispheric Brain Specialisation and Death of a Person",slug:"human-brain-anatomy-prospective-microgravity-hemispheric-brain-specialisation-and-death-of-a-person",totalDownloads:1557,totalCrossrefCites:0,totalDimensionsCites:3,abstract:"Central nervous system seems to float inside a craniospinal space despite having miniscule amount of CSF. This buoyancy environment seems to have been existing since embryogenesis. This indicates central nervous system always need microgravity environment to function optimally. Presence of buoyancy also causes major flexure to occur at midbrain level and this deep bending area of the brain, better known as greater limbic system seems to regulate brain functions and site for cortical brainwave origin. These special features have made it as a possible site for seat of human soul and form a crucial part in discussion related to death. Besides exploring deep anatomical areas of the brain, superficial cortical areas were also studied. The brainwaves of thirteen clinical patients were analysed. Topographical, equivalent current dipoles and spectral analysis for somatosensory, motor, auditory, visual and language evoked magnetic fields were performed. Data were further analysed using matrix laboratory method for bilateral hemispheric activity and specialization. The results disclosed silent word and picture naming were bilaterally represented, but stronger responses were in the left frontal lobe and in the right parieto-temporal lobes respectively. The sensorimotor responses also showed bilateral hemispheric responses, but stronger in the contralateral hemisphere to the induced sensation or movements. For auditory-visual brainwave responses, bilateral activities were again observed, but their lateralization was mild and could be in any hemisphere. The conclusions drawn from this study are brainwaves associated with cognitive-language, sensorimotor and auditory-visual functions are represented in both hemispheres; and they are efficiently integrated via commissure systems, resulting in one hemispheric specialization. Therefore, this chapter covers superficial, integrative and deep parts of human brain anatomy with emphasis on brainwaves, brain functions, seat of human soul and death.",book:{id:"5933",slug:"human-anatomy-reviews-and-medical-advances",title:"Human Anatomy",fullTitle:"Human Anatomy - Reviews and Medical Advances"},signatures:"Zamzuri Idris, Faruque Reza and Jafri Malin Abdullah",authors:[{id:"42580",title:"Prof.",name:"Jafri",middleName:"Malin",surname:"Abdullah",slug:"jafri-abdullah",fullName:"Jafri Abdullah"},{id:"73844",title:"Prof.",name:"Zamzuri",middleName:null,surname:"Idris",slug:"zamzuri-idris",fullName:"Zamzuri Idris"},{id:"200214",title:"Dr.",name:"Faruque",middleName:null,surname:"Reza",slug:"faruque-reza",fullName:"Faruque Reza"}]},{id:"66388",doi:"10.5772/intechopen.85177",title:"Orexin System and Avian Muscle Mitochondria",slug:"orexin-system-and-avian-muscle-mitochondria",totalDownloads:864,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"In mammals, orexin A and B (also known as hypocretin 1 and 2) are two orexigenic peptides produced primarily by the lateral hypothalamus that signal through two G-protein-coupled receptors, orexin receptors 1/2, and have been implicated in the regulation of several physiological processes. However, the physiological roles of orexin are not well defined in avian (non-mammalian vertebrate) species. Recently, we made a breakthrough by identifying that orexin and its related receptors 1/2 (ORXR1/2) are expressed in avian muscle tissue and cell line, and appears to be a secretory protein. Functional in vitro studies showed that orexin A and B differentially regulated expression of the orexin system, suggesting that orexins might have autocrine, paracrine, and/or endocrine roles. Administration of recombinant orexin modulated mitochondrial biogenesis, dynamics, function, and bioenergetics. In this chapter, we include a brief overview of the (patho) physiological role of orexin, comparative findings between mammalian and avian orexin, and in-depth analysis of orexin’s action on avian muscle mitochondria.",book:{id:"7870",slug:"muscle-cells-recent-advances-and-future-perspectives",title:"Muscle Cells",fullTitle:"Muscle Cells - Recent Advances and Future Perspectives"},signatures:"Kentu Lassiter and Sami Dridi",authors:[{id:"274577",title:"Ph.D. Student",name:"Kentu",middleName:null,surname:"Lassiter",slug:"kentu-lassiter",fullName:"Kentu Lassiter"},{id:"274579",title:"Dr.",name:"Sami",middleName:null,surname:"Dridi",slug:"sami-dridi",fullName:"Sami Dridi"}]},{id:"66964",doi:"10.5772/intechopen.85903",title:"Vascularisation of Skeletal Muscle",slug:"vascularisation-of-skeletal-muscle",totalDownloads:926,totalCrossrefCites:0,totalDimensionsCites:3,abstract:"Skeletal muscle is mainly involved in physical activity and movement, which requires a large amount of glucose, fatty acids, and oxygen. These materials are supplied by blood vessels and incorporated into the muscle fiber through the cell membrane. In contrast, metabolic waste is discarded outside the cell membrane and removed by blood vessels. The formation of a functional, integrated vascular network is a fundamental process in the growth and maintenance of skeletal muscle. On the other hand, vascularization is one of the main central components in skeletal muscle regeneration. In order for regeneration to occur, blood vessels must invade the transplanted muscle. This is confirmed by the fact that muscle regeneration occurred from the outside of the muscle bundle toward the inner regions. In fact, it is likely that capillary formation is a key process to start muscle regeneration. Thus, vascularization activates muscle regeneration, and a decrease in vascularization could lead to disruption the process of muscle regeneration. Also, a better understanding of vascularization of skeletal muscle necessary for the successful formation of collateral arteries and recovery of injured skeletal muscle may lead to more successful strategies for skeletal muscle regeneration and engineering. So, in this chapter, we want to review vascularization in skeletal muscle.",book:{id:"7870",slug:"muscle-cells-recent-advances-and-future-perspectives",title:"Muscle Cells",fullTitle:"Muscle Cells - Recent Advances and Future Perspectives"},signatures:"Kamal Ranjbar and Bayan Fayazi",authors:[{id:"143655",title:"Ph.D. Student",name:"Kamal",middleName:null,surname:"Ranjbar",slug:"kamal-ranjbar",fullName:"Kamal Ranjbar"},{id:"299168",title:"Dr.",name:"Bayan",middleName:null,surname:"Fayazi",slug:"bayan-fayazi",fullName:"Bayan Fayazi"}]}],mostDownloadedChaptersLast30Days:[{id:"70162",title:"Rehabilitation of Lateral Ankle Sprains in Sports",slug:"rehabilitation-of-lateral-ankle-sprains-in-sports",totalDownloads:1245,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Lateral ankle sprains are one of the most common injuries in athletes. The rate of injury is as high as 70%. The most commonly involved ligament is the anterior talofibular ligament (ATFL), followed by the calcaneofibular (CFL) and posterior talofibular ligament (PTFL). The common mechanism of injury is inversion with excessive ankle supination in forced plantarflexion when the ankle joint is in its most unstable position. There are three grades of ankle sprains: Grade I, mild with an incomplete tear of ATFL; Grade II, moderate with a complete tear of ATFL with or without an incomplete tear of CFL; and Grade III, severe with complete tear of ATFL and CFL. Grades I and II respond well to functional treatment. Functional treatment includes RICE protocol, i.e., rest, ice, compression, and elevation. It also includes range of motion and strengthening exercises, proprioceptive training, and sports-specific exercises. Bracing and taping of the ankle joint help in preventing the sprains and also reduce the recurrence of the injury. Grade III ankle injury may be treated with surgery if the symptoms persist post functional treatment. The guidelines provided for the treatment of ankle sprains are of general validity, but each athlete is different with different needs. Hence, a personalized exercise protocol should be followed to achieve best results.",book:{id:"9413",slug:"essentials-in-hip-and-ankle",title:"Essentials in Hip and Ankle",fullTitle:"Essentials in Hip and Ankle"},signatures:"Rachana Dabadghav",authors:[{id:"305115",title:"M.Sc.",name:"Rachana",middleName:null,surname:"Dabadghav",slug:"rachana-dabadghav",fullName:"Rachana Dabadghav"}]},{id:"55330",title:"Mesencephalon; Midbrain",slug:"mesencephalon-midbrain",totalDownloads:3385,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"The mesencephalon is the most rostral part of the brainstem and sits above the pons and is adjoined rostrally to the thalamus. It comprises two lateral halves, called the cerebral peduncles; which is again divided into an anterior part, the crus cerebri, and a posterior part, tegmentum. The tectum is lay dorsal to an oblique coronal plane which includes the aquaduct, and consist of pretectal area and the corpora quadrigemina. In transvers section, the cerebral peduncles are seen to be composed of dorsal and ventral regions separated by the substantia nigra. Tegmentum mesencephali contains red nucleus, oculomotor nucleus, thochlear nucleus, reticular nuclei, medial lemnisci, lateral lemnisci and medial longitudinal fasciculus. In tectum, the inferior colliculus and superior colliculus have main nucleus, which are continuous with the periaqueductal grey matter. The mesencephalon serves important functions in motor movement, particularly movements of the eye, and in auditory and visual processing. The mesencephalic syndrome cause tremor, spastic paresis or paralysis, opisthotonos, nystagmus and depression or coma. In addition cranial trauma, brain tumors, thiamin deficiency and inflammatory or degenerative disorders of the mesencephalon have also been associated with the midbrain syndrome.",book:{id:"5933",slug:"human-anatomy-reviews-and-medical-advances",title:"Human Anatomy",fullTitle:"Human Anatomy - Reviews and Medical Advances"},signatures:"Ayla Kurkcuoglu",authors:[{id:"200913",title:"Prof.",name:"Ayla",middleName:null,surname:"Kurkcuoglu",slug:"ayla-kurkcuoglu",fullName:"Ayla Kurkcuoglu"}]},{id:"64758",title:"Introductory Chapter: Histological Microtechniques",slug:"introductory-chapter-histological-microtechniques",totalDownloads:2281,totalCrossrefCites:2,totalDimensionsCites:2,abstract:null,book:{id:"7329",slug:"histology",title:"Histology",fullTitle:"Histology"},signatures:"Vonnie D.C. Shields and Thomas Heinbockel",authors:[{id:"70569",title:"Dr.",name:"Thomas",middleName:null,surname:"Heinbockel",slug:"thomas-heinbockel",fullName:"Thomas Heinbockel"}]},{id:"63843",title:"Salivary Glands",slug:"salivary-glands",totalDownloads:3945,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Saliva is a fluid secreted by the salivary glands that keeps the oral cavity moist and also coats the teeth along with mucosa. The salivary gland possesses tubuloacinar units, and these are merocrine. The functional unit of the salivary glands is the terminal secretory piece called acini with a roughly spherical or tubular shape. It also consists of branched ducts for the passage of the saliva and also plays an important role in the production and modification of saliva. Each type of duct is lined by different types of epithelia, on the basis of its location. Myoepithelial cells are contractile cells with respect to intercalated and secretory endpieces. Parotid, submandibular, and sublingual glands are the major salivary glands. The minor salivary glands are labial and buccal gland, glossopalatine gland, and palatine and lingual glands. Saliva plays an important role in mastication, speech, protection, deglutition, digestion, excretion, tissue repair, etc. Secretion stimulated in response to sympathetic stimulation will differ in protein and electrolyte from that due to parasympathetic stimulation. The concentration of saliva depends only on the rate of flow and not on the nature of stimulus. Saliva guides the clinician toward the optimal mode of treatment and guides the patient toward ultimate prognosis.",book:{id:"7329",slug:"histology",title:"Histology",fullTitle:"Histology"},signatures:"Sonia Gupta and Nitin Ahuja",authors:[{id:"245048",title:"Dr.",name:"Sonia",middleName:null,surname:"Gupta",slug:"sonia-gupta",fullName:"Sonia Gupta"},{id:"258367",title:"Dr.",name:"Nitin",middleName:null,surname:"Ahuja",slug:"nitin-ahuja",fullName:"Nitin Ahuja"}]},{id:"55062",title:"Human Anatomy: A Review of the Science, Ethics and Culture of a Discipline in Transition",slug:"human-anatomy-a-review-of-the-science-ethics-and-culture-of-a-discipline-in-transition",totalDownloads:2292,totalCrossrefCites:10,totalDimensionsCites:13,abstract:"Anatomy has undergone radical changes over its history, and even now its appearance varies between audiences. Within academia, it has frequently been seen as the bastion of medical teaching, even as a handmaid of surgery. To the general public over recent years, it is represented by the enormously popular public exhibitions of plastinated cadavers and body parts. Increasingly within medical teaching, it has acquired a far more humanistic face, epitomized by ceremonies at the start and end of dissection to connect the dead body with the once living individual and his/her families. Modern anatomy has also developed a strong research ethos. These movements can be traced in the many editions of Gray’s Anatomy, from 1858 to the present day. However, the humanistic side of anatomy reminds us that anatomy is not merely a science, since its ethical dimensions are legion as it has transformed from a dubiously moral and barely legal activity to one that now aims to manifest the highest of ethical standards. Nevertheless, it continues to have challenging dimensions, such as its ongoing dependence upon the use of unclaimed bodies in many societies. These challenges are reminders that anatomy does not remain stationary.",book:{id:"5933",slug:"human-anatomy-reviews-and-medical-advances",title:"Human Anatomy",fullTitle:"Human Anatomy - Reviews and Medical Advances"},signatures:"David Gareth Jones",authors:[{id:"35851",title:"Prof.",name:"Gareth",middleName:null,surname:"Jones",slug:"gareth-jones",fullName:"Gareth Jones"}]}],onlineFirstChaptersFilter:{topicId:"1064",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:31,numberOfPublishedChapters:314,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:105,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:14,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"3",title:"Bacterial Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/3.jpg",isOpenForSubmission:!1,editor:null,editorTwo:null,editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. 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She is now a lecturer at the University of Witwatersrand, South Africa, and a principal researcher at the Health Economics and Epidemiology Research Office (HE2RO), South Africa. Dr. Moolla holds a Ph.D. in Psychology with her research being focused on mental health and resilience. In her professional work capacity, her research has further expanded into the fields of early childhood development, mental health, the HIV and TB care cascades, as well as COVID. She is also a UNESCO-trained International Bioethics Facilitator.",institutionString:"University of the Witwatersrand",institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"342152",title:"Dr.",name:"Santo",middleName:null,surname:"Grace Umesh",slug:"santo-grace-umesh",fullName:"Santo Grace Umesh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/342152/images/16311_n.jpg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"333647",title:"Dr.",name:"Shreya",middleName:null,surname:"Kishore",slug:"shreya-kishore",fullName:"Shreya Kishore",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333647/images/14701_n.jpg",biography:"Dr. Shreya Kishore completed her Bachelor in Dental Surgery in Chettinad Dental College and Research Institute, Chennai, and her Master of Dental Surgery (Orthodontics) in Saveetha Dental College, Chennai. She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. 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