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Rajeev Tyagi

CSIR-Institute of Microbial Technology (IMTECH)

Dr. Rajeev K. Tyagi completed his doctorate (Ph.D.) in Immunology/parasitology/Infectiology with a special mention of 'Tres Honorabel” at Biomedical Parasitology Unit, Institute Pasteur, Paris, France (2011) on a very challenging and demanding area of translational biomedical research. He developed 'humanized” mouse model(s) to study asexual blood and liver stage infection of P. falciparum with an objective to explore vaccine candidates, drug discovery and drug resistance. Dr. Tyagi worked at the University of South Florida as Postdoc fellow and used the developed humanized mouse to characterize attenuated asexual blood stage falciparum parasite. In addition, he made efforts to develop human-liver chimeric mice using TK/NOG mice to study liver stage infections of P. falciparum. Dr. Tyagi worked at Augusta University, USA as senior research associate and developed an understanding of the Pathogen differentiated dendritic cells and their implication in developing therapeutic interventional approaches for chronic periodontitis. Dr. Tyagi has been working to understand the role of nano-carriers in order to develop therapeutic approaches to address cancer, rheumatoid arthritis and systemic inflammatory diseases. He has published 34 research articles in various journals of international repute and contributed 5 chapters to the international books. Currently, he is working as Assistant Professor in Institute of Science, Nirma University, Ahmedabad and his lab is funded by DST-SERB, New Delhi.

1books edited

2chapters authored

Latest work with IntechOpen by Rajeev Tyagi

Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.

Immune Response Activation and Immunomodulation

Immune Response Activation and Immunomodulation

Edited by Rajeev Tyagi

Chapters authored

Liposome-Mediated Immunosuppression Plays an Instrumental Role in the Development of “Humanized Mouse” to Study Plasmodium falciparum

By Kunjal Agrawal, Vishwa Vyas, Yamnah Hafeji and Rajeev K. Tyagi

The material world has been getting prone toward infectious diseases, and therefore novel strategies should be devised to treat chronic infectious disorders. The translational biomedical research scientists made early attempts to develop mouse-human chimera (humanized mouse) through the reconstitution of immunodeficient mouse with engraftment of human cells and tissues. Although the humanized mouse proved to be an effective tool in understanding various diseases such as human malaria and hepatitis, however, drug administration, retention capacity of the administered drug, toxicity, and ethical constraints are some of the major issues and need to be objectively addressed. The “humanization” of immunodeficient mouse needs pharmacological immunomodulatory reagents to control the excessively recruited cells of monocyte-macrophage lineage. Therefore, administration of liposome loaded with hydrophobic drug (clodronate) to induce selective apoptosis through “suicidal approach” in myeloid cells plays an instrumental role for controlling residual nonadaptive immune response of the host. Liposomes are spherical and hollow—structures consisting of lipid bilayer—and are used for the delivery of drug and vaccine candidates. The surface-engineered liposomes (ligand anchored) are used for targeted and controlled delivery. Clodronate-loaded liposomes play a pivotal role in developing humanized mouse. This mouse holds relevance to study pathophysiology and immunopathology of human malaria parasite, P. falciparum. The liposomal delivery of clodronate administered in immunodeficient mice to modulate their innate immune system is an amenable strategy with the minimal/acceptable range of systemic toxicity.

Part of the book: Liposomes

Introductory Chapter: Immunity and Immunomodulation

By Rajeev K. Tyagi

Part of the book: Immune Response Activation and Immunomodulation

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