Parameters of the test.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"5873",leadTitle:null,fullTitle:"Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis",title:"Poisoning",subtitle:"From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis",reviewType:"peer-reviewed",abstract:"This book, which is the result of contributions from a team of international authors, presents a collection of materials that can be categorized into two groups. The first group of papers deals with clinical toxicology topics including poisoning by anticoagulant rodenticides, food toxins, carbon monoxide, the toxicity of beta-lactam antibiotics, acute neonicotinoid poisoning, occupational risk factors for acute pesticide poisoning, activating carbon fibers, and date pits for use in liver toxin adsorption. The second group of papers deals with forensic or analytical toxicology topics such as simplified methods for the analysis of gaseous toxic agents, rapid methods for the analysis and monitoring of pathogens in drinking water and water-based solutions, as well as the linkages between clinical and forensic toxicology. Each chapter presents new information on the topic discussed based on authors' experience while summarizing existing knowledge. As such, this book will be a good teaching aid and can be a prescribed or recommended reading for postgraduate students and professionals in the fields of public health, medicine, pharmacy, nursing, biology, toxicology, and forensic sciences.",isbn:"978-953-51-3682-8",printIsbn:"978-953-51-3681-1",pdfIsbn:"978-953-51-3988-1",doi:"10.5772/65817",price:119,priceEur:129,priceUsd:155,slug:"poisoning-from-specific-toxic-agents-to-novel-rapid-and-simplified-techniques-for-analysis",numberOfPages:218,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"42ddd66c136bcb87140fa1f5b60f9726",bookSignature:"Ntambwe Malangu",publishedDate:"December 20th 2017",coverURL:"https://cdn.intechopen.com/books/images_new/5873.jpg",numberOfDownloads:21228,numberOfWosCitations:32,numberOfCrossrefCitations:25,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:56,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:113,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"December 6th 2016",dateEndSecondStepPublish:"December 20th 2016",dateEndThirdStepPublish:"September 15th 2017",dateEndFourthStepPublish:"October 15th 2017",dateEndFifthStepPublish:"December 15th 2017",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"84773",title:"Prof.",name:"Ntambwe",middleName:null,surname:"Malangu",slug:"ntambwe-malangu",fullName:"Ntambwe Malangu",profilePictureURL:"https://mts.intechopen.com/storage/users/84773/images/system/84773.jpg",biography:"Prof Ntambwe Malangu, born in Kabinda, Congo (DRC), is a pharmacoepidemiologist with public health expertise in drug safety issues. He is currently the Head of Department of Epidemiology and Biostatistics at the School of Public Health at Sefako Makgatho Health Sciences University, Pretoria, South Africa; and the Production Editor for PULA: Bostwana Journal for African studies as well as a reviewer for a handful of international peer-reviewed journals. He has worked in both private and public sector of the healthcare industry in several African countries. From 2006, he has been working as an international health consultant and technical advisor with major development partners. In this capacity, he has contributed to several health systems strengthening initiatives across the Anglophone, Lusophone and Francophone African countries. He is a well-known trainer in supply chain management of health commodities and pharmaceuticals as well as in pharmacy and public health practice themes. Malangu holds a Bachelor degree in Pharmacy from the University of Kinshasa (1991) and a Master of Medical Science degree (Pharmacology and Toxicology) from the Medical University of Southern Africa (2003), a PhD degree (Pharmacoepidemiology and Pharmacovigilance, 2007) and a Doctor of Medical Sciences (Injury Epidemiology and Toxicovigilance) from the University of Limpopo (2012). Malangu has over 60 publications including scientific abstracts and letters, books, book chapters and full papers.",institutionString:"Sefako Makgatho Health Sciences University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Sefako Makgatho Health Sciences University",institutionURL:null,country:{name:"South Africa"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1010",title:"Toxicology",slug:"emergency-medicine-toxicology"}],chapters:[{id:"56630",title:"Introductory Chapter: Linkages Between Clinical and Forensic Toxicology",doi:"10.5772/intechopen.70303",slug:"introductory-chapter-linkages-between-clinical-and-forensic-toxicology",totalDownloads:1144,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Ntambwe Malangu",downloadPdfUrl:"/chapter/pdf-download/56630",previewPdfUrl:"/chapter/pdf-preview/56630",authors:[{id:"84773",title:"Prof.",name:"Ntambwe",surname:"Malangu",slug:"ntambwe-malangu",fullName:"Ntambwe Malangu"}],corrections:null},{id:"56530",title:"Poisoning by Anticoagulant Rodenticides in Humans and Animals: Causes and Consequences",doi:"10.5772/intechopen.69955",slug:"poisoning-by-anticoagulant-rodenticides-in-humans-and-animals-causes-and-consequences",totalDownloads:1847,totalCrossrefCites:10,totalDimensionsCites:17,hasAltmetrics:0,abstract:"Anticoagulant rodenticides (ARs) are a keystone of the management of rodent populations in the world. The widespread use of these molecules raises questions on exposure and intoxication risks, which define the safety of these products. Exposures and intoxications can affect humans, domestic animals and wildlife. Consequences are different for each group, from the simple issue of intoxication in humans to public health concern if farm animals are exposed. After a rapid presentation of the mechanism of action and the use of anticoagulant rodenticides, this chapter assesses the prominence of poisoning by anticoagulant rodenticides in humans, domestic animals and wildlife.",signatures:"Sébastien Lefebvre, Isabelle Fourel, Stéphane Queffélec, Dominique\nVodovar, Bruno Mégarbane, Etienne Benoit, Virginie Siguret and\nVirginie Lattard",downloadPdfUrl:"/chapter/pdf-download/56530",previewPdfUrl:"/chapter/pdf-preview/56530",authors:[{id:"180156",title:"Dr.",name:"Virginie",surname:"Lattard",slug:"virginie-lattard",fullName:"Virginie Lattard"},{id:"185579",title:"Dr.",name:"Sébastien",surname:"Lefebvre",slug:"sebastien-lefebvre",fullName:"Sébastien Lefebvre"},{id:"185580",title:"Prof.",name:"Etienne",surname:"Benoit",slug:"etienne-benoit",fullName:"Etienne Benoit"},{id:"209023",title:"Dr.",name:"Isabelle",surname:"Fourel",slug:"isabelle-fourel",fullName:"Isabelle Fourel"},{id:"209031",title:"Mr.",name:"Stéphane",surname:"Queffélec",slug:"stephane-queffelec",fullName:"Stéphane Queffélec"},{id:"209032",title:"Dr.",name:"Bruno",surname:"Megarbane",slug:"bruno-megarbane",fullName:"Bruno Megarbane"},{id:"209033",title:"Dr.",name:"Dominique",surname:"Vodovar",slug:"dominique-vodovar",fullName:"Dominique Vodovar"},{id:"209034",title:"Prof.",name:"Virginie",surname:"Siguret",slug:"virginie-siguret",fullName:"Virginie Siguret"}],corrections:null},{id:"56521",title:"Food Poisoning Caused by Bacteria (Food Toxins)",doi:"10.5772/intechopen.69953",slug:"food-poisoning-caused-by-bacteria-food-toxins-",totalDownloads:5884,totalCrossrefCites:9,totalDimensionsCites:20,hasAltmetrics:1,abstract:"In the environment, there are polluting substances that can cause adverse reactions in human beings when entering the body through different ways (ingestion, inhalation, injection, or absorption). The main pollutants can be poisons, chemical compounds, toxic gases, and bacterial toxins. These can be found in different places and their effects depend on the dose and exposure time. Furthermore, foodborne diseases (FBDs) can cause disability; these diseases can be caused by toxins produced by bacteria or other toxic substances in the food, which can cause severe diarrhea, toxic shock syndrome, debilitating infections such as meningitis and even death. FBDs are transmitted through food contaminated with pathogenic microorganisms that have multiple factors of virulence, which gives them the ability to cause an infection; some bacterial genres can produce toxins directly in the food, but other genres can produce them once they have colonized the intestine. Among the pathogens involved in FBDs that are also considered to be toxigenic are Salmonella spp., Vibrio parahaemolyticus, Vibrio cholerae, Staphylococcus aureus, Clostridium botulinum, Clostridium perfringens, Bacillus cereus, Listeria monocytogenes. Foodborne diseases can be prevented and acute diarrhea syndromes, fever and even death from dehydration can be avoided, especially in children under the age of 5 and in immunocompromised people.",signatures:"Cecilia Hernández-Cortez, Ingrid Palma-Martínez, Luis Uriel\nGonzalez-Avila, Andrea Guerrero-Mandujano, Raúl Colmenero Solís\nand Graciela Castro-Escarpulli",downloadPdfUrl:"/chapter/pdf-download/56521",previewPdfUrl:"/chapter/pdf-preview/56521",authors:[{id:"204160",title:"Prof.",name:"Graciela",surname:"Castro-Escarpulli",slug:"graciela-castro-escarpulli",fullName:"Graciela Castro-Escarpulli"},{id:"204162",title:"Dr.",name:"Cecilia",surname:"Hernández-Cortez",slug:"cecilia-hernandez-cortez",fullName:"Cecilia Hernández-Cortez"},{id:"204163",title:"MSc.",name:"Ingrid",surname:"Palma-Martinez",slug:"ingrid-palma-martinez",fullName:"Ingrid Palma-Martinez"},{id:"204164",title:"MSc.",name:"Luis Uriel",surname:"González-Avila",slug:"luis-uriel-gonzalez-avila",fullName:"Luis Uriel González-Avila"},{id:"204165",title:"MSc.",name:"Andrea",surname:"Guerrero-Mandujano",slug:"andrea-guerrero-mandujano",fullName:"Andrea Guerrero-Mandujano"}],corrections:null},{id:"56446",title:"Carbon Monoxide Intoxication: Experiences from Hungary",doi:"10.5772/intechopen.70010",slug:"carbon-monoxide-intoxication-experiences-from-hungary",totalDownloads:2994,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Carbon monoxide (CO) is odorless, colorless, tasteless, and nonirritating gas. Hence, mild CO poisoning often remains unrecognized and appears lethally. Carbon and gas systems, unfavorable architectural designs and machines may also cause intoxications. The prevalence rates in Hungary ranged from 2.37 to 3.80 cases per 100,000 people per year between 2013 and 2015; fatality rates have been decreased from 5.96 in 2013 to 3.38 in 2015. Given the vagueness and the broad spectrum of complaints, misdiagnosis of CO toxicity is common. The gold standard diagnosis is detecting the level of circulating carboxyhemoglobin (CO-Hgb). The measurement of CO-Hgb can be performed via blood-gas analyses or by spectrophotometry. Treatment protocol should follow the ACBDE rule. Administration of 100% oxygen should be performed as soon as possible. Later in-hospital management includes evaluation, treatment and prevention of further peripheral organ damage and long-term neurological complications. Fetuses and children are prone to suffer more severe intoxication due to higher oxygen demand. Though hyperbaric oxygen is the mainstay therapy, a prompt cesarean section is effective in preventing further intoxication. In conclusion, fatal CO intoxication can occur due to plain early signs and symptoms. Hyperbaric oxygen therapy should be considered in severe intoxication, in fetal and children.",signatures:"Edit Gara",downloadPdfUrl:"/chapter/pdf-download/56446",previewPdfUrl:"/chapter/pdf-preview/56446",authors:[{id:"198479",title:"Ph.D.",name:"Edit",surname:"Gara Dr",slug:"edit-gara-dr",fullName:"Edit Gara Dr"}],corrections:null},{id:"56551",title:"Toxicity of β-Lactam Antibiotics: Pathophysiology, Molecular Biology and Possible Recovery Strategies",doi:"10.5772/intechopen.70199",slug:"toxicity-of-lactam-antibiotics-pathophysiology-molecular-biology-and-possible-recovery-strategies",totalDownloads:1682,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Beta (β)-lactam antibiotics are wide-spectrum antibiotics used for various bacterial infections. The aim of this chapter is to summarize the knowledge about the toxicity of β-lactam antibiotics and issues associated to their inappropriate use. This review has highlighted that β-lactam antibiotics are a group of products that have a chemical structure characterized by a β-lactam ring and are one of the most common antibacterial agents. However, due to the inappropriate use including abuse and misuse, resistance to the β-lactam antibiotics is currently a global crisis. Moreover, even when used appropriately, they have been linked to triggering allergic reactions like urticaria, bronchoconstriction, also severe conditions like immune-mediated haemolytic anaemia and intravascular haemolysis. It is known that some β-lactam antibiotics are neurotoxic, some are nephrotoxic, some are genotoxic and some are toxic to urogenital system. Several factors are involved in the occurrence of toxic effects including the dosage and renal status. Several strategies are possible to overcome β-lactam antibiotics-triggered toxicity, including rational prescribing, substitution combination and phage therapy which seems promising. Public health education for clinical teams and patients is essential in ensuring that this group of antibiotics are retained in therapeutics.",signatures:"Elif Bozcal and Melih Dagdeviren",downloadPdfUrl:"/chapter/pdf-download/56551",previewPdfUrl:"/chapter/pdf-preview/56551",authors:[{id:"190684",title:"Ph.D.",name:"Melih",surname:"Dagdeviren",slug:"melih-dagdeviren",fullName:"Melih Dagdeviren"},{id:"203449",title:"Ph.D.",name:"Elif",surname:"Bozcal",slug:"elif-bozcal",fullName:"Elif Bozcal"}],corrections:null},{id:"57953",title:"Acute Poisoning with Neonicotinoid Insecticide",doi:"10.5772/intechopen.72004",slug:"acute-poisoning-with-neonicotinoid-insecticide",totalDownloads:1900,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Neonicotinoids are a class of insecticides considered less toxic to humans than organophosphates, carbamates, organochloride and pyrethroids. The purpose of this chapter was to systematize existing data in the literature on acute intoxication with neonicotinoids to help practitioners. Clinical manifestations vary across different human systems. Gastrointestinal symptoms consist of nausea, vomiting, abdominal pain and corrosive lesions. In the central nervous system, headaches, agitation, confusion, fasciculations, seizures or coma may occur, while tachycardia or bradycardia, hypertension, hypotension and palpitations occur in the cardiovascular system. Respiratory effects are dyspnea, aspiration pneumonia or respiratory failure. Solvents that drive the insecticide also have an important role in the toxic effects. There are no specific biological tests of neonicotinoid intoxication, and their dosing is not routinely available. Treatment is symptomatic. Mortality is less than 3%, well below the poisoning with anticholinesterase insecticides, like organophosphates and carbamates.",signatures:"Nicolai Nistor, Otilia Elena Frăsinariu and Violeta Ştreangă",downloadPdfUrl:"/chapter/pdf-download/57953",previewPdfUrl:"/chapter/pdf-preview/57953",authors:[{id:"219606",title:"Dr.",name:"Nicolai",surname:"Nistor",slug:"nicolai-nistor",fullName:"Nicolai Nistor"},{id:"219884",title:"Dr.",name:"Otilia",surname:"Frasinariu",slug:"otilia-frasinariu",fullName:"Otilia Frasinariu"},{id:"219885",title:"Dr.",name:"Violeta",surname:"Streanga",slug:"violeta-streanga",fullName:"Violeta Streanga"}],corrections:null},{id:"57898",title:"Occupational Risk Factors for Acute Pesticide Poisoning among Farmers in Asia",doi:"10.5772/intechopen.72006",slug:"occupational-risk-factors-for-acute-pesticide-poisoning-among-farmers-in-asia",totalDownloads:1449,totalCrossrefCites:0,totalDimensionsCites:4,hasAltmetrics:1,abstract:"Types of pesticides are used in farming to increase the productivity and protection of crops or to control pests. However, exposure to acute pesticide poisoning is one of the most important occupational risk factors among farmers all over the world. They are directly exposed to high levels of pesticide poisoning when involved in the handling, spraying, mixing, or preparing of it. The low educational level, lack of information, training, judgment or experience, and the inability to read on pesticide safety are playing an important role for farmers’ acute poisoning. On the other side, poor technology, inadequate personal protection, inappropriate type of clothing and equipment also leads to farmers? acute poisoning. Hence, this paper focuses on occupational risk factors for acute pesticide poisoning among farmers and their occupational safety. Discovering risk factors is also crucial for investigating health problems of farmers and its inevitable effects on their body. As it is seen from previous studies instead of field research such as deep interview on farmers’ acute poisoning, data were mostly collected from hospitals. This study tries to emphasize the importance of field study to discover the risk factors for acute pesticide poisoning among farmers and their occupational safety in Asia.",signatures:"Emine Selcen Darçın, Murat Darçın, Murat Alkan and Gürdoğan\nDoğrul",downloadPdfUrl:"/chapter/pdf-download/57898",previewPdfUrl:"/chapter/pdf-preview/57898",authors:[{id:"196869",title:"Dr.",name:"Murat",surname:"Darçın",slug:"murat-darcin",fullName:"Murat Darçın"},{id:"220223",title:"Dr.",name:"Murat",surname:"Alkan",slug:"murat-alkan",fullName:"Murat Alkan"},{id:"220224",title:"Prof.",name:"E. Selcen",surname:"Darçın",slug:"e.-selcen-darcin",fullName:"E. Selcen Darçın"},{id:"220225",title:"Dr.",name:"Gürdoğan",surname:"Doğrul",slug:"gurdogan-dogrul",fullName:"Gürdoğan Doğrul"}],corrections:null},{id:"57993",title:"Activating Carbon Fibers and Date Pits for Use in Liver Toxin Adsorption",doi:"10.5772/intechopen.71891",slug:"activating-carbon-fibers-and-date-pits-for-use-in-liver-toxin-adsorption",totalDownloads:1199,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Acute liver failure (ALF) is a rare, potentially fatal complication of severe hepatic illness. It is a syndrome that triggers a cascade of events, leading to multiple organ failures and often death. The work aimed at demonstrating the usefulness of activated raw date pits and carbon fiber reinforced polymers (CFRP) in the management of ALF. The activated carbons produced are used for adsorption of albumin bound toxins from the liver of patients with ALF. The liver is not cured, however, patients are given the time they need to find a suitable donor. Initially, date pits are milled and epoxy is removed from the CFRP. Both materials then undergo pyrolysis and activation treatments. The activated carbon fiber (ACF) and powdered activated carbon (PAC) resulting are tested using FTIR and TGA analysis. FTIR spectrums provide information about functional groups present in the samples and TGA graphs illustrate weight loss as treatment temperature increases. From the data analysis carried out, it appears that the process of recycling both; date pits and CFRP was successful. This confirms the ability of PAC and ACFs to adsorb toxins and as potential candidates for consideration in the search for effective treatment options for liver failure.",signatures:"Ameereh Seyedzadeh, Asel Mwafy, Waleed Khalil Ahmed, Kamala\nPandurangan and Ali Hilal-Alnaqbi",downloadPdfUrl:"/chapter/pdf-download/57993",previewPdfUrl:"/chapter/pdf-preview/57993",authors:[{id:"219694",title:"Ms.",name:"Ameera",surname:"Seyedzadeh",slug:"ameera-seyedzadeh",fullName:"Ameera Seyedzadeh"},{id:"222980",title:"Ms.",name:"Asel",surname:"Mwafy",slug:"asel-mwafy",fullName:"Asel Mwafy"}],corrections:null},{id:"56258",title:"Simplified Analysis of Toxic Gaseous Substance in Forensic Practice: Experiences from Japan",doi:"10.5772/intechopen.70029",slug:"simplified-analysis-of-toxic-gaseous-substance-in-forensic-practice-experiences-from-japan",totalDownloads:1160,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Toxicological examination in forensic practice is important for the proper diagnosis of acute poisoning. We have discussed the properties and features of poisoning incidents due to gaseous substances and elaborated on the simplified analytical techniques and apparatus used for their identification and quantitation for forensic purposes. Briefly, we have explained the simplified analysis of toxic gaseous substances such as carbon monoxide, hydrogen cyanide, hydrogen sulfide, and helium in blood. The techniques used include color testing, gas chromatography, detector tube, oximeter, and spectrophotometric method. In doing so, we have shared our experiences and highlighted the fact that the analysis of gaseous substances can be performed using readily available laboratory tools and equipment. We have emphasized the need and usefulness of the reference data tables for guiding forensic diagnosis. We hope that the above overview will assist other colleagues to implement such simplified techniques for the advancement of forensic medicine practice.",signatures:"Hiroshi Kinoshita, Naoko Tanaka, Ayaka Takakura, Mostofa Jamal,\nAsuka Ito, Mitsuru Kumihashi, Shoji Kimura, Kunihiko Tsutsui, Shuji\nMatsubara and Kiyoshi Ameno",downloadPdfUrl:"/chapter/pdf-download/56258",previewPdfUrl:"/chapter/pdf-preview/56258",authors:[{id:"200704",title:"Dr.",name:"Hiroshi",surname:"Kinoshita",slug:"hiroshi-kinoshita",fullName:"Hiroshi Kinoshita"},{id:"200706",title:"Dr.",name:"Naoko",surname:"Tanaka",slug:"naoko-tanaka",fullName:"Naoko Tanaka"}],corrections:null},{id:"56764",title:"Optical Express Methods of Monitoring of Pathogens in Drinking Water and Water-Based Solutions",doi:"10.5772/intechopen.70236",slug:"optical-express-methods-of-monitoring-of-pathogens-in-drinking-water-and-water-based-solutions",totalDownloads:833,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Hygienic standards to the quality of potable water require continuous monitoring of the absence of pathogenic microorganisms directly in water flow. Despite a great number of laboratory devices for checking the quality of potable water, there are no express analyzers for monitoring of pathogenic organisms, which could be embedded directly into the automatic checkout systems. The reasons of it are low concentration of pollutions and the presence of additional effects, which impede automatic data processing. The new method, the express analysis of pathogens in water, was developed. It shall be mentioned that the proposed method of express diagnostics allows detection of infectious agents in the water in minutes based on nonlinear effects. This research has, hopefully, laid the foundation for development of a prototype for determination of the content of the genetically modified soy in meat products. The inventive methods can be recommended for DNA diagnostics in medicine ,veterinary sciences and insanitation. The main advantage of this method is that there is no need for DNA isolation. It is sufficient to create a suspension of the product by centrifugation.",signatures:"Tatiana Moguilnaya and Aleksey Sheryshev",downloadPdfUrl:"/chapter/pdf-download/56764",previewPdfUrl:"/chapter/pdf-preview/56764",authors:[{id:"203863",title:"Dr.",name:"Tatiana",surname:"Mogilnaya",slug:"tatiana-mogilnaya",fullName:"Tatiana Mogilnaya"}],corrections:null},{id:"57270",title:"The Aflatoxin QuicktestTM—A Practical Tool for Ensuring Safety in Agricultural Produce",doi:"10.5772/intechopen.71331",slug:"the-aflatoxin-quicktesttm-a-practical-tool-for-ensuring-safety-in-agricultural-produce",totalDownloads:1136,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Contamination of corn, peanuts, milk and dairy products with aflatoxins is a worldwide problem, particularly in subtropical regions where the climatic conditions are ideal for the growth of Aspergillus flavus, the fungi that produces these toxins. Developing countries have major difficulties in marketing these products abroad due to the stringent international regulations concerning this carcinogenic toxin. Adding to the problem is the analytical cost involved in monitoring the produce, which require sophisticated instrumentation and qualified personnel, neither of which are available for field testing. The development of a rapid Aflatoxin Quicktest™ provides an effective, reliable and cheaper option for screening levels of aflatoxin above the regulatory thresholds in such produce. The test consists of a lateral flow device (LFD) coated with antibodies specific to aflatoxin B1, although it detects other aflatoxins (i.e. G and M) with high cross-reactivity. Its high sensitivity allows analysis of these toxins in the range 2–40 μg/kg of sample in 15 minutes, plus the time for extraction, which varies among different products. Quantification of the test results is done using a Quick Reader, by comparing the readings of individual tests against a standard curve of the analytes in the same manner as it is done with any other analytical equipment. A validation study was carried out using peanuts from Australia and peanuts and corn from Timor-Leste to assess the performance of the Aflatoxin Quicktest™. Results obtained with the LFD showed a good correlation with the standard analytical measurements by HPLC-fluorescence (r2 above 0.90 for all cases), indicating the Aflatoxin Quicktest™ is capable of measuring levels of aflatoxins accurately and reliably. Given their ease of use, low cost and fast processing time, the Aflatoxin Quicktest™ can be used for screening agricultural produce in countries that cannot afford the costly alternative of using specialised personnel and equipment.",signatures:"Francisco Sánchez-Bayo, Luis de Almeida, Robert Williams, Graeme\nWright, Ivan R. Kennedy and Angus Crossan",downloadPdfUrl:"/chapter/pdf-download/57270",previewPdfUrl:"/chapter/pdf-preview/57270",authors:[{id:"74970",title:"Dr.",name:"Francisco",surname:"Sánchez-Bayo",slug:"francisco-sanchez-bayo",fullName:"Francisco Sánchez-Bayo"},{id:"221610",title:"Mr.",name:"Luis",surname:"De Almeida",slug:"luis-de-almeida",fullName:"Luis De Almeida"},{id:"221611",title:"Mr.",name:"Robert",surname:"Williams",slug:"robert-williams",fullName:"Robert Williams"},{id:"221613",title:"Dr.",name:"Graeme",surname:"Wright",slug:"graeme-wright",fullName:"Graeme Wright"},{id:"221614",title:"Prof.",name:"Ivan",surname:"Kennedy",slug:"ivan-kennedy",fullName:"Ivan Kennedy"},{id:"221615",title:"Dr.",name:"Angus",surname:"Crossan",slug:"angus-crossan",fullName:"Angus Crossan"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6192",title:"Pharmacokinetics and Adverse Effects of Drugs",subtitle:"Mechanisms and Risks Factors",isOpenForSubmission:!1,hash:"9fd7489523195c8182a8b61caf9141b3",slug:"pharmacokinetics-and-adverse-effects-of-drugs-mechanisms-and-risks-factors",bookSignature:"Ntambwe Malangu",coverURL:"https://cdn.intechopen.com/books/images_new/6192.jpg",editedByType:"Edited by",editors:[{id:"84773",title:"Prof.",name:"Ntambwe",surname:"Malangu",slug:"ntambwe-malangu",fullName:"Ntambwe Malangu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. 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Further studies showed that 92% of the population variance is due to genetic factors, and only a fraction of AS genetics can be explained by the influence of HLA-B27. Updated information on the genomic and auto-immune knowledge on AS is an important component of this book, calling attention to markers of disease activity, possible pathways, and the interaction with the gut microbiome, which are a step forward in the knowledge of the pathophysiology of AS, providing markers which are targets for the more recent biologic therapies.
\r\n\tAn update on clinical manifestations, their assessment, monitoring, and imagiology, including peripheral arthritis, enthesopathy, and extra-articular findings, and, the differential diagnosis with other diseases which evolves with axial and peripheral calcifications will be provided.
\r\n\t
\r\n\tAn important component of this book must be dedicated to the more recent treatments namely with biologic therapies but focusing also on new small molecule inhibitors and experimental therapies.
Coordinate measuring machines (CMMs) are becoming increasingly important in measurements and the verification of the dimensional quality of manufactured parts and products. First, today’s gear inspection is a description of the nominal geometry of the gear teeth, which are limited some flank profile traces. The new principle of the corrected determination of the measured point in the metrology of coordinates is brought to the system of the fuzzy logic. This means that for the measurement with great accuracy of a complex surface’s mechanical part, we propose a new algorithm for the compensation of the tip of the radius of the stylus in a process of scanning by three-dimensional coordinate CMMs. The proposed algorithm is dedicated to high-definition measurement. Advantages of the algorithm are that we do not calculate the normal vector and we do not use a Non-uniform rational basis spline (NURBS) is a mathematical model commonly used in computer graphics for generating and representing curves and surfaces. It offers great flexibility and precision for handling both analytic and modeled shapes. In general, editing NURBS curves and surfaces is highly intuitive and predictable. Control points are always either connected directly to the curve / surface, or act as if they were connected by a rubber band [1]. The method is based on the fuzzy logic algorithm, which is a well-known method to approximate the ideal position that minimizes the sum of the squared residual errors between the clearance and the model. This choice is motivated by the robustness of this method and it is important to underline here that no attempt to implement it within the coordinate measuring machine (CMMs) software has been reported in the three-dimensional metrology literature. Digital applications have dealt with the case of a gear tooth gear that is fitted to the gearbox of machine tools. The comparison between the real surface obtained by the three-dimensional measuring machine and the ideal model that gives us defects of shape of the tooth. But this precision is generally obtained only for the measurement of well-known shapes of the piece measured and when its dimensions greatly exceed the radius of the tip of the probe, and for this reason, the algorithm is used for the correction of the radius of the probe. For example, simple surfaces form profiles that are not geometric primitive sections known as planes (circle, sphere, cone, gear, etc.).
\nMetrology engineering has employed fuzzy logic in the detection of the defect of gears with straight cylindrical teeth. It has also been applied to process control, the modeling of the developing profile of a tooth circle, its optimizations, looks for defects in shape, and position. In this research, we investigate these applications in more detail. See the synoptic of fuzzy logic in Figure 1.
\nSynoptic of fuzzy logic.
Pressure angle remains the same throughout the operation, and the teeth are weaker. It is easier to manufacture due to its convex surface. The velocity is not affected due to the variation in the central distance. Interference takes place; there is more wear and tear as contact takes place between convex surfaces (Figure 2).
\nInvolute profile.
Firstly, the probing obstacle is in zones 1 and 2 when the information is entered by the tridimensional measuring machine (see Figure 3). Indeed, we saw that the segment (ab) is undefined after having transferred the coordinates of the center of the ball. That is, there are no coordinates for probing this one (Figure 3-1), and the same goes for zone 2; when we did the transfer, no results were interpreted because the segment (ab) is unknown. To solve this problem of probing, we apply the system and notions of fuzzy logic.
\nProblem of probing the tooth of a wheel.
As regards the measurement with high accuracy on CMMs, we specify the probe path. For this, we propose a new algorithm for the compensation of the radius of the tip of the stylus in a process of scanning the surface of the tooth by CMMs. The proposed algorithm is dedicated to the measurement of high definition. It is done to calculate the normal vector.
\nThe proposed compensation method consists of the following steps [1]:
realization of a series of high-density measurements on the characteristic of geometry measured by the spherical stylus tip,
contour of the sample defines a bow per ball, for each measured point,
calculating the points of intersection
for each arc, the estimate of the point of contact with
determination of angular compensation using the fuzzy logic knowledge base and the application of compensation based on the corresponding angular adjustment.
The calculation of angles
We consider point Oi as one of the data points describing the position of the center of the ball of the spherical stylus registered by the CMMs (see Figure 4) [5]. We take the previous additional points
Analyzes the geometry of the sweep path for the determination of the measured point corrected.
Mathematical model: sections (A-A), (B-B) and (C-C).
All three circles have a radius R equal to the radius of the stylus ball, with which the preliminary calculations of the CMMs are made, according to the qualification of the probe system. All points of the arc are selected to transfer the corrected measured points associated with the measured points
In the first estimate, a preliminary point
The choice of input and output variables depends on the control we want to achieve and the available parameters. In our chapter, we can consider the entries
The outputs are based on the problem that was posed; anyway, we can find one or more outputs and so on. Finally, it is lucid that the outputs in our work are two:
First, we proposed the parameters in our tests on the CMMs, which are within the Metrology Laboratory of ENP-Oran (see Table 1). These are very important for simulation calculations.
\n\n | Minimum value | \nMaximum value | \n
---|---|---|
t (s) | \n— | \n250 | \n
θ (radian) | \n0.2 | \n30 | \n
xm (mm) | \n— | \n26 | \n
ym (mm) | \n— | \n26 | \n
i | \n100 | \n200 | \n
Δki | \n— | \n200 | \n
Δzi | \n— | \n200 | \n
αi | \n— | \n200 | \n
Parameters of the test.
So this step allowed us to give the different linguistic variables that will be used during the gear control by the fuzzy logic [7, 8, 9, 10, 11, 12, 13, 14, 15].
\nIndeed, we exploit Table 2 to build the inference of fuzzy logic in C; however, we do not have to complete all the boxes. The rules are developed by an expert and his knowledge of the problem [12, 13, 15].
\nMatrix of fuzzy logic.
The matrix is in the form of Table 2 or a matrix that we can build according to the previous parameters,
Over the last 20 years, remarkable progress has been made in three-dimensional measurement technology with regard to the mechanical elements of the machine, control equipment, and software.
\nThe accuracy of the probe during scanning is generally several tens of micrometers, but this accuracy is generally not achieved for the measurement of well-known shapes as well as when the size of the part greatly exceeds the radius of the feeler ball because of the algorithms used for the sharp radius of correction stylets.
\nFor example, spline profiles that do not compose a part of a geometric primitive known as (circle, sphere, cone, torus, etc.), they present particular difficulties to establish the method of the normal vector. Left surfaces are now very common (car, bodies, consumer products of ergonomic shapes, turbine blades, etc.).
\nIn addition, small features become commonplace and, although measurements are made by digitization, the correction can result in the introduction of unacceptable errors [16, 17, 18].
\nIn fact, this semi-experimental part is very important for applying these notions of fuzzy logic to the contour of the flank of the left or right tooth. However, we are able to bring back information through a known mathematical model or by asking a laboratory to provide it to us. In short, the result of the processing of information is the same, either by borrowing the mathematical model or by directly probing by CMM (see Figures 4, 5, 6) [8, 11].
\nFlowchart of fuzzy estimator logic.
The presentation of the fuzzy logic algorithm has been introduced (see Figure 6); this logic affects one or more steps of the algorithm to try to increase its performance including accuracy and speed, and there are several variables. Some of these variables expand, and the abbreviation of the corresponding iterative point asserts that it would be a good response to the algorithm. To make an algorithm choice, there are several criteria that must be checked:
speed,
precision,
stability,
robustness and simplicity.
The importance of any of these four criteria depends on the application of the final program. The development of a complete system of the quality inspection of the manufactured parts requires the coordination of a set of processes to acquire data, its dimensional evaluations, and comparisons with the proposed reference model. For this, it is essential to make certain conceptual knowledge profitable not only for the object to be analyzed but also for the environment. In this case, the goal of this chapter is to establish a procedure for automating the modeling of the surface inspection of complex parts such as gears. Allowing to correct the relative differences of the manufacturing parameters, then, the adopted criteria includes fast convergence, the robustness of the system, and the simplicity of the interface. Finally, the new algorithm is summarized by the diagram of the following flowchart [2]:
\nWe used the following equations to achieve these results (see Figure 7). Equation of right which is between the points
Determination of
The equation of the line that passes through the point
The equation between two points
The equation of the line that passes through the point
We take theoretically the tolerance values for each point gained in the range (
Equation of the circle includes
\n(see Figure 7)
\nr is the radius of the probe sphere (
We have determined the following values \n
We can take the numbers that vary between i = 1 and 200 points.
\nScreen printing of Δzi, Δki, defuzzification, Δαi conclusions according to Mamdani rules [
Section
We can calculate the coordinates of the points
Then, the values
Section
According to the graphs of fuzzy logic, we can conclude the values of
In our work, we use the generalized bell shape:
\nwhere z (r) and k (r) represent the values of the linguistic variables of the deviations
After applying the fuzzy logic and plotting the tooth curve, we notice that the green curve is far from the ideal curve; this is the normal vector method. But blue tracing is closer to this one because of having dots that define the involute curve, the red curve is closer to the curve of fuzzy logic (see Figure 9).
\nIn that case, we find that the intersection between the involute curve and the outer circle gives a large deviation as expected. In addition, this leads to an increase in errors, that is, the increase in the gap (see Figure 10).
\nFor example, if we determine the height of the tooth by the formula h
So, it is intolerable to accept miscalculations of more than
In this case, there is no difference between the two methods (fuzzy logic and the normal vector), the error is zero. However, the method
Section
Combination of the x and y coordinates by forming the tooth.
Concluding that the proposed method presents the maximum error in curve peaks, among its values are 0.15, 0.14, 0.1, and 0.1 mm. These peaks have been found to represent intersections between two curves. The weakness of this method is in the intersections of the curves. But in the journey with himself, he does not have any difference.
\nIndeed, it has been deduced that the result of fuzzy logic is the closest to the ideal curve because of some points that appeared to define the involute curve; at this moment; we could not calculate them by the normal vector method. The graph was constructed by the following formula:
\nThe fuzzy logic algorithm is used to estimate the actual tooth area of the gears. The performance results given by our approach were compared to the performance of these data using the ideal model.
\nIt is clear that the use of the fuzzy logic estimator is appropriate and estimates the actual area of the tooth which consists of a very complicated path when detecting teeth by CMMs in the sense that the application of the logic technique with estimation of dynamic non-linear systems, special cases, and the surface of the gear which contains several parameters is the best (see Figure 13).
\nCalculation of the error of the result of the fuzzy logic and the normal vector.
Anyway, this problem is solved by this approach. Thus, the role of this work is the determination of the tooth curve to estimate the shape defect of the gears. In our future work, we will try to implement other learning algorithms such as the Kalman estimator or fuzzy neuron.
\nIn this respect, we can conclude that by the principle of fuzzy logic, there is not really the right or the wrong answer as has already been pointed out several times. While the choice of calculation method the profile taken is conditioned between the installation and the performance according to the designer.
\nSome researchers even suggest averaging the different methods, but this is not a generalization, and the calculations become even more complicated. Finally, we mention that this problem of probing is solved, thanks to the development of the fuzzy logic, which relies on the linguistic knowledge, nonlinearity, and not the needs of the model; the solution was obtained by means of a computer. Nevertheless, it lacks precise guidelines for the design, because of contradictory inference rules.
\nToday’s global population is estimated to be over 7.9 billion people, which is expected to reach 9.9 billion in 2050, 34% higher than it is now [1]. Developing countries will account for nearly all of this overpopulation. To feed this growing population, agricultural lands must be used considerably more effectively, and production should be boosted by 70% compared to today’s values [2]. Besides, agricultural production areas are unfortunately facing major ecological challenges, owing to human misapplications, natural calamities, as well as the impact of global climate change [3]. As a result of these factors, today the condition of our current lands is deteriorating leaving us with no choice but to grow nutrient-rich, chemical-free agricultural produce for human and animal use while using far less water and arable land than in the past. This is why a focus on both quality and quantity should be placed on food production without depleting natural resources. Developing and disseminating improved agricultural methods and technologies are equally critical.
Since cultivation areas are dwindling year after year, fertilizer mineral is a world market item that is vital to produce a higher plant yield per unit area and attain food security. It must be available in adequate quantities and in the proper balance to close the gap between nutrient supply from soil and organic sources and nutrient demand for optimal crop development [4]. Not just that, fertilizer is critical for the nation’s economy to grow, as agriculture is the primary source of employment. By 2025, it will ensure food security for more than 8 billion people around the globe [5]. The increase in the use of chemical fertilizers by approximately 5 million tons in 10 years is a situation that should be considered while the agricultural areas are decreasing. However, it is more necessary to keep the soil’s plant nutritional balance by considering climate, soil, and plant characteristics rather than the amount of chemical fertilizers utilized, and fertilizing based on soil analysis is critical.
Fertilizer is recognized as one of the most valuable agricultural production inputs, and synthetic fertilizers are becoming increasingly popular around the world. The global fertilizer market was valued at $155.8 billion in 2019, with a compound annual growth rate (CAGR) of 3.8% predicted for the forecast period (2019–2024) [6]. Fertilizer consumption climbed from 10,777,779 million tons in 2015 to 14,495,815 million tons in 2020, a record high. The total global demand for fertilizers (N + P + K) was estimated at 198.2 million metric tons (mmt) in 2020/2021, according to the International Fertilizer Association (IFA). This was nearly 10 mmt, or 5.2% higher than in 2019–2020 and was the highest rise since the 2010–2011 fiscal year. Nitrogen experienced a 4.1% increase in demand to 110 mmt. Phosphorus demand increased by 7.0% (3.3 Mt), reaching 49.6 Mt., while demand for potash rose by 6.2% (2.2 Mt) to 38.5 Mt. [7]. In the last 50 years, the amount of chemical fertilizer used throughout the world has increased dramatically (Figure 1) [8].
Global usage of chemical fertilizer since 1970 [
Chemical fertilizers have also become more popular in Turkey in recent years, where the cultivation areas are decreasing every year, the need for fertilization is increasing, since more plant production per unit area is required. According to TUIK (Turkish Statistical Institute) 2021 statistics, both the use of fertilizers and nitrogen fertilizers has increased in agricultural production in Turkey in the last 10 years. TUIK statistics showed that annual fertilizer use in Turkey increased from 9,074,308 tons to 14,495,815 tons between 2010 and 2020, and the use of nitrogenous fertilizers increased from 5,995,500 tons to 9,774,691 tons within these values. The amount of fertilizer per unit production area is 107 kg/ha. The use of chemical fertilizers in agricultural inputs accounts for a share of 15–20% [9].
Advances in fertilization and agricultural applications have led to a significant increase in crop productivity in many regions, including Turkey. The most important chemical fertilizers applied to obtain more efficiency in plant production are those containing nitrogen, phosphorus, and potassium. Nitrogen fertilizers (N), however, are the most widely used chemical fertilizers in the world, as well as in Turkey, and play a unique role in plant production. Potassium fertilizers (K2O) are the second most consumed after nitrogen, followed by phosphorus fertilizers (P2O5) [8].
It has been determined that 87% of agricultural lands in Turkey have poor organic matter content [10]. Therefore, agricultural production is supported by fertilization, and nitrogen fertilizers constitute an important part of the total fertilizer applied. According to TUIK data, nitrogenous fertilizer usage rates as a percentage of total fertilizer use have shifted between 65 and 69% in the last 10 years [9]. Fertilizer use benefits plants in a variety of ways, including being a less expensive source of nutrients, having significant nutrient content and solubility, making it easily available to plants, and requiring less fertilizer, hence making it more suited than organic fertilizer [11]. Despite these advantages, mineral fertilizer has a number of negative environmental consequences as a result of rising consumption and decreased nutrient utilization efficiency. As a result, in intensive agricultural production systems, integrating intense cultivation with high nutrient utilization efficiency is a key difficulty.
Though conscious fertilization is desirable, the use of improper fertilizers can be extremely harmful, posing severe problems for current and future generations [12]. Sometimes, unfortunately, a wrong perception occurs among the producers of chemical fertilization. It is thought that more efficiency can be obtained by using more chemical fertilizers. Contrary to popular belief, the “LAW OF DECREASING PRODUCTION” is valid in fertilization. That is, the benefit derived from fertilization rises up to a point, after which continuing to apply fertilizer causes harm rather than a benefit.
The unintended and excessive use of chemical fertilizers to boost yields, as well as rising reliance on them, has a negative impact on the agricultural production system’s sustainability as well as financial losses in many countries today [13]. Certain factors, such as changes in fertilizer type, variations in application times, the producer’s lack of understanding in this area, and improper fertilizer applications, in particular, have been found to have quite substantial environmental consequences and threatening effects on the health and life of living creatures [14]. The inefficient and not demand-oriented fertilization applications in agricultural production can lead to soil acidity and soil crust, low organic matter and humus content, heavy metal accumulation, decrease in pH values, soil salinity, plant nutritional imbalances, limited plant growth, erosion, a decline in microbial activity and efficacy and emission of gasses containing substances that damage the atmosphere and the ozone layer, and eventually the greenhouse effect [15].
The issues at the forefront of the detrimental environmental effects of chemical fertilizers are highlighted here.
Excessive soil acidity induced by fertilizers is a major cause of soil degradation across the world. Fertilizers, especially nitrogen, acidify soil when applied in excess. This scenario has negative consequences, such as the crops’ incapacity to absorb phosphate, the proliferation of hazardous ion concentrations in the soil, hindrance of crop development, and suppression of microorganism activity [16]. If ammonium sulfate fertilizer is given to acidic soil, for example, the acidity level will become even higher. One-way ammonium sulfate fertilization of tea, according to research conducted in the Rize province of Turkey, considerably increased the acidity of low-pH soils. Currently, 85% of the land has fallen below pH 4, which is deemed critical. Likewise, in Nevsehir province, the pH of the soil has dropped to 2 as a result of nitrogen fertilization of potatoes grown in 100-fold increasing acidity over the last 25 years [17].
Hao et al. [18], carried out a field experiment to measure soil acidification rates in response to varied fertilizer sources and N rates, including control, optimal urea, conventional urea, optimized NH4Cl, and conventional NH4Cl plots, nitrogen addition resulted in average H+ production of 4.0, 8.7, 11.4, 29.7, and 52.6 keq ha−1 yr.−1, respectively. This was followed by a 1–10% decrease in soil base saturation and a 0.1–0.7 unit decrease in soil pH in the topsoil (0–20 cm). In a greenhouse study conducted to evaluate the effect of conventional nitrogen fertilizer on soil salinity and acidity, a significant rise in both soil acidity and salinity was witnessed as N input increased after one season, with pH decrease ranging from 0.45 to 1.06 units [19]. Moreover, after 21 years of application, chemical N fertilizer dropped the soil pH from 6.20 to 5.77, a 0.02 pH unit drop per year [20]. In another study, an evaluation of the impact of long-term fertilizing techniques on soil samples revealed a fall in soil pH from 8.4 to 7.5 [21]. Because nutrients are less available to plants in acidic soil, serious plant nutritional deficiencies are prevalent, resulting in overall crop reduction.
Heavy metal deposition in soils is mostly caused by the manufacture and consumption of industrial products, although fertilizers and pesticides used in agriculture also contribute significantly. Arsenic (As), copper (Cu), nickel (Ni), cadmium (Cd), and uranium (Ur), among other heavy metals, can build up in the soil following repeated chemical fertilizer applications, particularly phosphorus (P) fertilizers and their source material [22, 23, 24]. These toxic heavy metals not only pollute the environment, but they may also cause soil degradation, plant development retardation, and perhaps impair human health through food chain contamination harming the central nervous system, circulatory system, excretory system, and cardiovascular system, as well as cause bone damage, endocrine disruption, and possibly cancer [25].
Phosphorus (P) fertilizer is widely utilized in agriculture due to its vital function in crop growth and production [26]. However, P fertilizer has been recognized as the predominant cause of HMs pollution in soil when compared to potassium (K) and nitrogen (N) fertilizers [27]. According to a 10-year field trial, P fertilization aided Zn, Pb, Cd, and As buildup in the topsoil. With increasing P application, the threshold cancer risk (TCR) associated with As and Cd increased [28]. Likewise, another experiment concluded that frequent application of P fertilizer and the extended residence period of HMs may generate a large accumulation of HMs in soils [29].
Heavy metals are concentrated in agricultural soil as a result of improper application of commercial fertilizers, manure, sewage, or sewage sludge [30]. The results of the study conducted by Huang and Jin [31] suggested that the long-term usage of exaggerated synthetic fertilizers and organic manures contributed to the heavy metals (HMs) accumulation in the soils. Research carried out by Atafar et al. [32], confirmed that the fertilizer use enhanced the amounts of Cd, Pb, and As in cultivated soils. Before fertilization, the Cd, As, and Pb concentrations in the studied location were 1.15–1.55, 1.58–11.55, and 1.6–6.05 mg/kg, respectively; after harvesting, values were 1.4–1.73, 26.4 5.89, and 2.75–12.85 mg/kg soil for Cd, As, and Pb, respectively. The findings of another study concluded that chemical fertilizer usage increased the availability of Cu, Ni, Pb, and Zn as well as the buildup of Cd, Cu, and Zn in the greenhouse soil [33].
Salts are a common component of chemical fertilizers and are considered destructive to agriculture because they harm soil and plants. Increases in the salinity of the soil can be seen by natural or artificial means. Artificially induced salinity is the result of the accumulation of fertilizers used in large quantities over long periods of time in areas where intensive farming is practiced, making the soils unsuitable for production [22, 34, 35]. Following one season of conventional nitrogen fertilizer, electrolytic conductivity increased from 0.24 to 0.68 mS cm−1 [19]. Long-term intensive farming raised soil electrical conductivity (ECe), which rose from “low salinity” (1.5 dS m−1 0.49) to “highly saline” (6.6 dS dS m−1 1.35) levels [21].
Soil salinity is a major global issue that has a negative impact on agricultural output. Salinization of agricultural land diminishes economic advantages greatly, as demonstrated by Welle and Mauter [36] in California, where salinization lowered overall agricultural income by 7.9%.
Inorganic fertilizers used recklessly can cause nutritional imbalances in the soil, thus limiting the intake of other essential nutrients. If the common NPK type is frequently used, secondary and micronutrient deficiencies occur in the soil and crop. Excess nitrogen and phosphate fertilizers, for instance, enable the plant to absorb more potassium than it requires. In acidic soils, lime and lime-containing fertilizers lead to the retention of micro plant nutrients, such as P, B, Fe, and Zn in the soil. Over-applied phosphorus fertilizers also prevent the uptake of nutrients, such as Ca, Zn, and Fe, and reduce their efficacy [22, 37].
Soil compaction is a key component of the land degradation syndrome and a serious issue for modern agriculture, negatively impacting soil resources [38]. Overuse of fertilizers for extended periods of time and intensive cropping are two of the main causes of compaction. Chemical fertilizers damage soil particles, resulting in compacted soil with poor drainage and air circulation [39]. Reduced soil aeration has an impact on soil biodiversity. Microbial biomass may be diminished as a result of severe soil compaction. Soil compaction may not affect the amount of macrofauna, such as earthworms, but it does affect the distribution of macrofauna, which is important for soil structure.
Soil compaction leads to high soil strength and bulk density, poor drainage, poor aeration, limited root growth, erosion, runoff, and soil deterioration, hence resulting in low permeability, hydraulic conductivity, and groundwater recharge [40, 41]. High soil compaction stifles root growth, reducing the plant’s ability to absorb nutrients and water. Compaction, according to reports, reduces root growth and yield by more than 80% [42]. As the soil bulk density increases, nitrification drops by 50%, and plants use less N, P, and Zn from the soil [43]. The findings of the research conducted by Massah and Azadegan [44] suggested that in non-compacted and severely compacted soils, bulk density increased from 1.34 to 1.80 Mg.m−3, and penetration resistance increased from 0.89 to 3.54 MPa, respectively. Soil compaction reduced permeability by 81.4%, accessible water by 34%, and yields by 40%.
In agricultural production, the unintentional, excessive, or random application of chemical fertilizers and pesticides degrades the chemical, biological, and physical structure of the soil, resulting in a rise in pathogen and pest populations [45, 46]. Moreover, with intensive and unconscious chemical fertilizer applications, the amount of organic matter in the soil decreases, which adversely affects the microorganism activities and causes the structure of the soil to deteriorate. If the same fertilization errors are repeated, soil structures will deteriorate with each passing year, plant growth will slow as fertilizer doses are increased, and the overall amount of product obtained will decrease. Some of the fertilizers will not be able to hold on to the soil and will be removed with the water. The conversion of nutrients into forms that plants can benefit from will be reduced.
Soil microbial activity is a crucial component of soil health, and soil organisms serve as a mechanism for nutrient recovery, as well as provide a variety of other environmental functions. Chemical fertilizer misuse can have a detrimental and lethal effect on soil quality and microbial community structure, including earthworms, and other soil inhabitants. Prolonged consumption of chemical fertilizers can cause a significant drop in soil pH, which has been associated with a decrease in bacterial diversity and major changes in bacterial community composition [47]. Nitrogen usage in agriculture has a deleterious influence on the nitrogen cycle and the activities of related bacterial communities, including nitrogen-fixing microorganisms such as Rhizobium sp. [48]. Besides, excess nitrogen fertilizers limit the activities of nitrifying bacteria [49].
It is critical to emphasize the importance of understanding how to apply chemical fertilizers properly. Chemical fertilizers, as part of their larger threat to the environment, animals, and human health, eventually leak into our water bodies, such as ponds, streams, and groundwater, contaminating water supplies, exposing humans and animals to a variety of short- and long-term hazardous chemical effects on their health and bodies. In ideal conditions, it is estimated that roughly 2–10% of fertilizers interfere with surface and groundwater [50]. The accumulation of nitrates in the water emerges as a result of the use of N fertilizers in the agricultural field, which is increasing day by day. Even under ideal conditions, only 50% of the nitrogen fertilizer given to the soil can be taken up by plants; 2–20% evaporates, 15–25% combines with organic compounds in the clay soil, and 2–10% is discharged into streams, rivers, and streams with surface runoff [50, 51]. Nitrate, a frequent contaminant of surface and groundwater, can cause serious health concerns, including inflammation of the colon, stomach, and urine systems. Furthermore, these compounds have been reported as carcinogens that can have a harmful impact on human health. They also have the potential to induce disorders in infants, such as methemoglobinemia, a condition in which the blood carrying capacity is limited due to a decrease in hemoglobin.
Though the rise in agricultural productivity alleviated poverty, it also posed a threat to the ecosystem due to its negative consequences. Rising levels of synthetic fertilizer application for agricultural production, for instance, increase greenhouse gas emissions, eroding the protective ozone layer, and exposing humans to harmful ultraviolet radiation [52]. Above all, agriculture is responsible for a major fraction of the greenhouse gas (GHG) emissions that are driving climate change, accounting for 17% directly from agriculture activities and another 7–14% through land-use changes.
During the production of nitrogenous fertilizer, greenhouse gases, such as CO2, CH4, and N2O are released. Moreover, nitrous oxide emissions from soils, fertilizers, manure, and urine from grazing animals, as well as methane generation by ruminant animals and paddy rice agriculture, are the most significant direct agricultural GHG emissions. Both of these gases have a far larger potential for global warming than carbon dioxide.
Agriculture is the primary source of anthropogenic N2O emissions, accounting for 60% of total emissions. It has a 310-fold greater global warming potential than carbon dioxide. Excess nitrogen fertilizer application results in nitrogen oxide emissions (NO, N2O, NO2), which cause serious air pollution [51]. The primary issue with nitrous oxide emissions is the impact of global warming and the function of nitrous oxides in ozone degradation, encouraging the decomposition of the ozone layer [53] and resulting in atmospheric “holes,” exposing humans and animals to excessive UV radiation [54]. Water vapor, hydrogen sulfide, and chloro-fluoro hydrocarbons are among the other gases that contribute to ozone depletion [55].
After being volatilized or released from fertilized fields, ammonia is deposited in the atmosphere and oxidized to generate nitric and sulfuric acids, resulting in acid rain. Acid rain has the potential to harm flora, buildings, and species that live in lakes and reservoirs [56]. Methane emissions from transplanted paddy fields are also a major concern, as methane is a powerful greenhouse gas whose concentration is doubled when ammonium-based fertilizers are used. These gases all contribute to global warming and climate change [57].
Climate change is gaining traction, resulting in major global temperature spikes, as well as the prevalence of additional abiotic stressors that are reducing crop output. Significant production losses in major grain crops have been attributed to climate change, resulting in 3.8% yield reductions for maize and 5.5% for the wheat [58, 59].
Fertilization, which is one of the most essential inputs in agricultural operations, increases productivity on the one hand, but its overuse might have negative consequences on the other. Excessive usage of agricultural chemicals jeopardizes the long-term viability of agriculture. Today, the fast expansion in agricultural productivity has begun to slow down [45, 56]. Clean food production becomes inevitable with a healthy and reliable agriculture system that does not require chemicals.
Given that chemical fertilization cannot be completely eliminated in agricultural applications, in this scenario, sustainability initiatives and the usage of ecologically sound technologies can help achieve the goal of enhancing healthier crop productivity whilst eliminating unnecessary input and thereby mitigating harsh weather conditions, as well as improving soil health by sequestering carbon and retaining organic material and mineral nutrients in the soil [60]. Hence, it is vital to use alternatives, such as Plant-Growth-Promoting Rhizobacteria (PGPR), to support sustainable agricultural productivity and everlasting soil fertility and to build production strategies that will aid in the proliferation of beneficial soil microorganisms activities.
The rhizosphere is a well-defined ecological niche that consists of the volume of soil surrounding plant roots and is home to a wide range of microbial species [61, 62]. As a result of phytomicrobiome research, certain plant-microbe interactions that directly aid in plant nutrition are beginning to emerge [63]. Microbes have the power to positively influence plant growth and combat the majority of modern agriculture’s challenges, making them a promising alternative for agricultural sustainability. The rhizomicrobiome is indispensable for agriculture because of the extensive diversity of root exudates and plant cell debris that attract diverse and unique patterns of microbial colonization. Fertilizer requirements are often lower in soils with dynamic microbial ecologies and rich organic matter than in traditionally treated soils [64].
Despite the fact that the rhizosphere is home to a diverse range of microbes, including bacteria, fungi, algae, protozoa, and actinomycetes, bacterial colonies are predominant [65, 66]. The bacterial community in the soil, in particular, has the potential to proliferate quickly and use a wide variety of nutrient sources. A group of natural soil bacterial flora that resides in the rhizosphere and grows in, on, or around plant roots [67] and has a beneficial effect on the plant’s overall health is referred to as PGPR [68]. PGPR is a nonpathogenic, beneficial bacterium that promotes plant growth by modifying hormone levels and nutritional requirements, as well as reducing stress-related damage [69]. Nutrient absorption is thought to be increased as a result of the increased root surface area mediated by PGPR. Besides, they mineralize organic contaminants and are employed in polluted soil bioremediation [70]. When compared to other microorganisms, PGPR has unique characteristics, such as the ability to synthesize growth regulators, nitrogen fixation, phosphorus solubilization, siderophore generation, nutrients, and mineral solubilization, demonstrating their exceptional tendency in stimulating plant growth [71]. They are also environmentally friendly and ensure that nutrients from natural sources are available at all times. In addition to stimulating plant growth through their active mechanisms, the bacterial colonies in the rhizosphere have a considerable influence on suppressing phytopathogenic microorganisms. Beneficial rhizobacteria can emit antibiotics and other chemicals that are effective at inhibiting pathogens [72].
The fundamental impacts that rhizosphere bacteria have on plants have evolved into an important mechanism for protecting plant health in an environmentally sustainable manner [73]. They participate in a variety of biotic activities in the soil ecosystem to keep it active and productive for farming systems [74]. Furthermore, in recent times, PGPR has garnered much attention for its potential to substitute agrochemicals for plant growth and yield through multiple processes, including decomposition of organic matter, recycling of essential elements, soil structure formation, production of numerous plant growth regulators, degrading organic pollutants, stimulation of root growth, and solubilization of mineral nutrients, which are important for soil health [75]. It is cost-effective and environmentally beneficial to replace chemical fertilizers with PGPR, as well as to identify the most effective soil and crop management approaches in an attempt to develop more sustainable farming and soil conservation fertility [76]. The employment of phytomicrobiome representatives as a long-term disease prevention and nutrient supplement method in farming production might help to reduce the negative impacts of pesticide usage [77]. The inoculated plant’s biocontrol and induction of disease resistance, biological N2 fixation, phosphate solubilization, and/or phytohormone synthesis are all potential explanations for PGPR’s growth-promoting actions [78].
PGPR has both direct and indirect modes of action as a biofertilizer and a biopesticide.
One of the most prevalent ways for increasing agricultural production is to improve soil fertility. PGPR promotes soil fertilization through the biofixation and biosolubilization processes (Figure 2).
PGPR’s mechanism of action [
Nitrogen (N) is found in all forms of life and is one of the most significant mineral nutrients for plant growth as it is a crucial component for various physiological activities in plants, including photosynthesis, nucleic acids, and protein synthesis [80]. Unfortunately, due to the low degree of reactivity, no plant species are capable of directly converting atmospheric dinitrogen into ammonia and using it for growth, hence making the plants dependent on biological nitrogen fixation (BNF). Nitrogen fertilizer, as being the most effective approach to nitrogen supplementation, has been an integral part of modern crop production and agricultural systems; yet, their continued and undesirable use is contaminating the climate. Though carbon dioxide (CO2) is widely regarded as the primary cause of climate change, nitrous oxide (N2O), which has a 265-fold higher heat-trapping efficiency than CO2 [81], is indeed a significant contribution. PGPR in this regard is a potential alternative to minimize the fertilizer requirements to a certain degree as the majority of the plant microbial community can either directly fix atmospheric nitrogen through legume-rhizobium interaction or indirectly by helping nitrogen fixers via their secretion [82].
Worldwide, total N fixation is estimated to be ∼175Tg, with symbiotic nitrogen fixation in legumes accounting for ∼ 80 Tg by fixing 20–200 kg N year-1, while the remaining nearly half (∼88 Tg) is industrially fixed during the production of N fertilizers [83]. The most prominent symbiotic nitrogen fixer is Rhizobium [84], whereas Azospirillum, Acetobacterdiazotrophicus, Azotobacter, Herbaspirillum, Cyanobacteria, Bacillus, Paenibacillus, Gluconacetobacter, and Azoarcus, etc., represent the free-living N fixers [85].
Symbiotic nitrogen fixation: A mutualistic association between a microorganism and a plant is known as symbiotic nitrogen-fixing. The N-fixing symbiosis between rhizobia and legumes is the most well-studied and utilized beneficial plant-bacteria interaction. In this interaction, legumes supply rhizobia with reduced carbon and a protected, anaerobic environment that is necessary for nitrogenase activity, while rhizobia feed legumes with biologically accessible nitrogen. The bacteria enter the root first, causing the growth of nodulation, which converts atmospheric nitrogen into usable forms (primarily NH3) [86]. Rhizobia can fix up to 200 kg of nitrogen ha − 1 by establishing symbiotic relationships with more than 70% of leguminous plants, thus making it available to plants.
Free-living nitrogen-fixing: Several nitrogen-fixing microorganisms do not interact in a symbiotic manner. These microorganisms are free-living and rely on plant leftovers or their own photosynthesis to exist. Although free-living nitrogen fixers do not enter the plant’s tissues, a tight interaction is developed where these bacteria reside close enough to the root that the atmospheric nitrogen fixed by the bacteria is taken up by the plant, resulting in greater nitrogen absorption. Besides, other bacteria that do not fix nitrogen have been demonstrated to boost nitrogen uptake in plants, resulting in increased nitrogen use efficiency [87], most likely due to increased root development, which allows plants to reach more soil [63]. Evidence of PGPR involvement in the plant N budget has been identified for various plants, particularly sugarcane [88].
Rhizobial N-fixation is an integrated approach for disease control, growth stimulation, as well as providing and maintaining the nitrogen level in agricultural soils around the world, thus minimizing the need for extensive N-fertilizer application and limiting the soil and environmental challenges associated with it.
Phosphorus (P) is the most significant vital element in plant nutrition (N), alongside nitrogen [89]. It is involved in a number of major metabolic activities in plants, including macromolecular biosynthesis, photosynthesis, respiration, energy transfer, and signal transduction [90]. Although most soils hold a significant amount of phosphorus, which builds over time as a consequence of fertilizer treatments, plants have access to only a small portion of it. Despite the fact that P is abundant in both organic and inorganic forms in the soil, only 0.1% of it is available to plants because 95–99% of phosphate is either insoluble, immobilized, or precipitated [91]. Plants can absorb mono and dibasic phosphate on their own, but organic and insoluble phosphate must be mineralized or solubilized by microorganisms [92]. Phosphate anions are highly reactive and, depending on the soil quality, can be trapped by precipitation with cations including Mg2+, Ca2+, Al3+, and Fe3+. Plants cannot absorb phosphorus in these forms because it is highly insoluble. As a result, plants only get a small percentage of the total.
When deficient, phosphorus-based fertilizers are typically used to replenish soil P, which is readily available to plants. Supplementing P with commercial fertilizers, however, is not an ideal option due to their high cost and sometimes inaccessibility to plants since they are easily lost from the soil and subsequently mix with local streams, contaminating both terrestrial and aquatic environments [93]. Therefore, phosphorus solubilization, in addition to nitrogen fixation, is also vital biologically. Phosphate solubilization is among the most profound consequences of PGPR on plant nutrition. Persistent plant growth, PGPR, plays a major role in solubilizing phosphorus [94]. The potential of various bacterial species to solubilize insoluble inorganic phosphate compounds such as dicalcium phosphate, tricalcium phosphate, rock phosphate, and hydroxyapatite has been documented by many researchers. Phosphate can be dissolved in insoluble forms by a variety of PGPR, including Pseudomonas, Bacillus, and Rhizobium. PGPR solubilizes P by employing a number of mechanisms, including the synthesis of organic acids and extracellular enzymes, to make use of inaccessible forms of P, hence assisting in the availability of P for plant absorption. Miller et al. [95] pointed out two processes—acidification of the external medium via the release of low molecular weight organic acids (such as gluconic acid) that chelate phosphate-bound cations and the formation of phosphatases/phytases that hydrolyze organic forms of phosphate compounds. Phosphorus solubilizing bacteria (PSB) has been shown to lower the recommended P dose by approximately 25% [96] and is even more efficacious when combined with other PGPRs or mycorrhizal fungi, reducing the P supplementation to 50%. As a result, the risk of P runoff and eutrophication is mitigated [97].
Potassium (K) deficit has become a severe crop production bottleneck. Plants with insufficient potassium have poor root development, low seed production, a slow growth rate, and a decreased yield. Soluble potassium concentrations in soil are typically low; over 90% of the potassium in the soil is in the form of insoluble rocks and silicate minerals [98]. Several microbes, particularly fungal and bacterial genera, have close connections with plants and can release potassium in accessible form from potassium-bearing minerals in soils through the synthesis and secretion of organic acids [99, 100, 101]. Setiawati and Mutmainnah [101] synthesize organic acids produced by soil microorganisms, such as acetate, ferulic acid, oxalate, coumaric acid, and citrate, which significantly increase mineral dissolution rates and proton production by acidifying the soil rhizosphere and resulting in mineral K solubilization. As a result, using potassium-solubilizing PGPR as a biofertilizer in agricultural production can reduce agrochemical use while also encouraging environmentally friendly crop production.
Iron (Fe) is a major bulk mineral abundantly available on Earth, yet it is inaccessible in the soil for plants, owing to the fact that Fe3+ (ferric ion), the most common form of Fe found in nature, is hardly soluble [102]. PGPRs are the right fit to address this issue as they produce siderophores, which are tiny organic compounds that increase Fe absorption capability when it is scarce. Since PGPR can form siderophores, they are a valuable asset in supplying the plant with the necessary iron. Siderophores released by PGPRs boost plant growth and development via facilitating access to Fe in the soil surrounding the roots [103]. Plant growth can be stimulated directly by siderophore-producing bacteria, which improves plant Fe intake, or indirectly by suppressing the activities of plant pathogens in the rhizosphere, which limits their Fe availability [104]. Pathogen suppression is induced by the synthesis of siderophores, which decrease pathogen survival by chelating available Fe and therefore restricting pathogen survival [105]. In the presence of other metals, such as nickel and cadmium, a robust siderophore, such as the ferric-siderophore complex, is crucial for Fe uptake by plants [106]. Siderophores alleviate stress on the plants caused by potentially hazardous metals, such as Al, Cd, Cu, Pb, and Zn, found in polluted soil via forming stable compounds with them [107]. This phenomenon is beneficial for reducing plant stress induced by potentially harmful metals found in contaminated soils. Furthermore, siderophore-expressing rhizobacteria could be a potential alternative to chemical fertilizers by concurrently addressing salt-stress effects and Fe limitation in saline soils.
One of the many advantages of rhizobacteria in encouraging plant growth and controlling plant diseases is their ability to synthesize polysaccharides. Multifunctional polysaccharides, for instance, structural polysaccharides, intracellular polysaccharides, and extracellular polysaccharides, are synthesized by specific bacteria. Exopolysaccharide production is critical for biofilm development, and root colonization can influence microbial interactions with root appendages. The colonization of plant roots by EPS-producing bacteria aids in the separation of free and insoluble phosphorus in soils, circulating critical nutrients to the plant for appropriate growth and development, as well as protecting it against disease attacks. EPS-producing bacteria have a variety of roles in plant-microbe interactions, including protection against desiccation, stress [108], adherence to surfaces, plant invasion, and plant defense response [109]. Plant exopolysaccharides produced by plant-growth-enhancing rhizobacteria are critical in stimulating plant growth because they act as an active signal molecule during beneficial interactions and generate a defense response during the infection phase [110]. Some plant-growth-promoting rhizobacteria that produce exopolysaccharides can also bind cations, including Na+, implying that they may play a role in limiting the amount of Na + available for plant uptake and thereby reducing salt stress [111].
Phytohormones, commonly known as plant growth regulators, are organic chemicals that, at low levels (less than 1 mM), promote, inhibit, or modify plant growth and development [112]. Phytohormones are categorized based on where they act. Botanists recognize five main kinds of phytohormones: Auxins, Gibberellins, Ethylene, Cytokinins, Ethylene, and Abscisic acid.
Phytohormones stimulate root cell proliferation by overproducing lateral roots and root hairs, resulting in increased nutrition and water intake [113]. This is crucial for regulating nutrient uptake depending on soil composition and environmental circumstances. Slower primary root development and a spike in the proportion and length of lateral roots and root hairs are the most common effects.
Phytohormones play an important role in regulating developmental processes and signaling networks that are involved in plant adaptation to a variety of biotic and abiotic stressors [114]. Abiotic stressors, however, disrupt plant growth by altering endogenous levels of phytohormones [115]. Surprisingly, some bacteria, such as PGPR, may stimulate plants to produce phytohormones.
A diverse spectrum of rhizospheric microorganisms is capable of producing growth hormones that can promote cell proliferation in the root architecture by inducing an increase in nutrition and water intake by encouraging root hair growth, thus regulating overall plant growth and development, as well as activating pathogen defensive responses [116]. Important biological rhizobacteria can adjust to their surroundings and develop stress tolerance by repairing plant roots. The production of growth metabolites by PGPRs may help provide water stress resistance in host root colonization, resulting in higher optimal crop output.
Auxin is a critical molecule that regulates most plant functions, either directly or indirectly, and indole-3-acetic acid (IAA) is the most abundant and physiologically potent phytohormone that regulates gene expression by upregulating and downregulating it [116, 117]. More than 80% of rhizospheric bacteria have been known to be capable of synthesizing and releasing auxins. IAA produced by PGPR regulates a wide range of processes in plant development and growth, including cell division, differentiation, organogenesis, tropic responses, primary root elongation, and the formation of lateral roots [118]. As a result of the increased root surface area and length mediated by bacterial IAA, plants have better access to soil nutrients. Under salinity stress circumstances, the secretion of IAA by PGPR may have a key function in managing and regulating IAA concentrations in the root system, resulting in improved plant salinity stress responses [119]. Besides, microbe-induced IAA can boost root and shoot biomass output in water-stressed situations [120].
Gibberellins (GA) are another type of phytohormone produced by rhizobacteria. Different activities in higher plants, such as seed germination, root and leaf meristem size, cell division and stem elongation, floral induction, fruiting, and the flowering process, growth of the hypocotyl and stem, are all mediated by GA [121]. However, shoot elongation is by far the most significant physiological function of GA [122], which modifies the morphology of plants.
Cytokinins are a type of growth regulators that are responsible for seed germination, production of shoots, vascular cambium sensitivity, the proliferation of root hairs, improvement of cell division and root development, interactions of plants with pathogens, and nutrient mobilization and assimilation [123, 124], but suppress root elongation and lateral root formation [125, 126]. They are especially important for the cell cycle’s progression. Cytokinin, either alone or in combination with other phytohormones like abscisic acid and auxin, can help salt-stressed plants grow faster while also improving resistance by altering the expression of genes [127]. PGPRs, such as Bradyrhizobiumjaponicum, Azospirillumbrasilense, Pseudomonas fluorescens, Arthrobactergiacomelloi, Paenibacilluspolymyxa, and Bacillus licheniformis, have been demonstrated to produce cytokinin (particularly zeatin) [69]. Cytokinin-producing PGPRs act as biocontrol agents against a variety of pathogens [128].
PGPR has been proven in various investigations to be effective in both creating and regulating the amounts of ABA and gibberellic acid in plants. Gibberellins promote primary root elongation and lateral root development. Several PGPR, including Azotobacterspp, Azospirillumspp, Achromobacterxylosoxidans, Gluconobacterdiazotrophicus, Acinetobactercalcoaceticus, Bacillus spp., and Rhizobia spp., have been found to produce gibberellin [129].
The role of ABA under drought stress, for example, is well-known. Under conditions of water deficit, increased ABA levels cause stomata to shut, limiting water loss. This hormone, on the other hand, offers a variety of benefits during lateral root development [129]. Inoculation with Azospirillumbrasilense Sp245 increased ABA content in Arabidopsis, especially when grown under osmotic stress [130].
In addition to their roles in plant RSA, these two hormones are involved in plant defense mechanisms. As a result, PGPR, which produces these hormones, may affect the hormonal balance involved in plant defense, including the jasmonate and salicylic acid pathways [131].
As climate change conditions worsen, extreme environmental conditions that can cause significant annual losses in total crop output are now more prevalent worldwide [132, 133]. Many biotic and abiotic stresses are causing havoc on the sector, resulting in enormous plant productivity losses all around the world. Stress factors comprise nutrient shortages, heavy metal contamination, high wind, extreme temperatures, salinity, drought, illnesses, plant invasions, pests, salt, and soil erosion [69].
As a result of climate change, abiotic stresses, such as drought and high temperatures, have risen in frequency and intensity, resulting in 70% losses in major staple food crops, posing a danger to global food security [134]. Drought and high soil salinity, as well as their downstream impacts, such as osmotic, oxidative, and ionic stress, are regarded as important hindrances to long-term agriculture production [135]. Stressed plants suffer from internal metabolism disruption due to metabolic enzyme inhibition, substrate scarcity, excessive need for different chemicals, or a combo of the following. To endure unfavorable conditions, metabolic reconfiguration is required to comply with the demand for anti-stress compounds, such as suitable solutes, antioxidants, and proteins [136].
Agricultural breeding practices have tried to produce species that are more productive in unfavorable environments for ages. However, crop breeding for abiotic stress resistance has been impeded by a lack of reliable and consistent traits. Tolerance to stress is influenced by a number of genes working together. Furthermore, using agrochemicals to address biotic stresses and nutritional deficits contributes to environmental degradation, has a negative influence on the biogeochemical cycle system, and puts people at increased risk. The potential repercussions of the aforementioned stresses are significant, necessitating the development of robust, cost-effective, and environmentally acceptable methods to mitigate these stresses’ harmful effects on plants. As a result, there has been a spike in interest in environmentally friendly and organic agriculture techniques. Plant growth stimulants have been utilized in bio-fertilization, root revitalization, rhizoremediation, disease resistance, and other modes of microbial revival [137].
The efficient approach of PGPR can alleviate stresses that cause serious damage to crop yield, hence, the application of PGPR and/or their byproducts, which can help plants successfully resist extreme environmental circumstances, is one of the most eco-friendly ways [138]. Some PGPR genera, for instance, P. fluorescens, produce the enzymes 1-aminocyclopropane-1-carboxylate (ACC) deaminase and hydroxyacetophenone monooxygenase, which break down the ethylene precursor ACC to a-ketobutyrate and ammonia, thereby protecting plants from abiotic stressors [139]. The most destructive factors that reduce agricultural productivity are salinity and drought [140]. Furthermore, greater ethylene levels in the plant lead to premature fatuity symptoms, including leaf yellowing, abscission, and desiccation/necrosis [141]. PGPR is essential to minimize ethylene concentrations in plants, which in turn reduces stress.
During dry spells, turgor pressure and water potential have a significant impact on plant functionality. Drought stress results in substantial losses in agricultural output and the flow of nutrients, such as sulfates, nitrates, calcium, silica, and magnesium, as well as a reduction in photosynthesis activity [142]. To achieve sustainable agricultural productivity, bacterial colonies in the rhizosphere and endorhizosphere stimulate the plant to withstand drought [143]. PGPR releases osmolytes, which function in tandem with those obtained from plants to keep plants healthy and improve their growth and development, as well as withstand drought-related stress and excessive salt levels in the soil [144]. According to research findings, inoculating plants growing in dry and semi-arid areas with beneficial plant-growth-promoting rhizobacteria (PGPR), which enhances plant abiotic stress tolerance with an osmotic component, could improve drought tolerance and water utilization efficiency. PGPR-induced root development, nutrient uptake efficiency, and systemic tolerance have been proposed as biochemical changes in plants that result in increased abiotic stress tolerance (IST) [78].
Rise in global temperature and fluctuations in precipitation as a result of climate change have resulted in unprecedented crop pests and illnesses in various parts of the world [82]. Biotic agents, such as pathogenic bacteria, viruses, fungi, nematodes, protists, weeds, insects, and arachnids, are a prevalent concern in crop production and a long-term danger to sustainable agriculture and ecosystem stability around the world [145]. These species can induce biotic stress in their hosts by interfering with normal metabolism, injuring their plant hosts, reducing plant vigor, limiting plant development, and/or inducing plant mortality. Biotic stress has an impact on co-evolution, ecosystem nutrient cycling, population dynamics, horticulture plant health, and natural habitat ecology [146]. They also result in pre- and post-harvest damage to agricultural crops [147].
According to the FAO, pests are estimated to be responsible for up to 40% of global agricultural production losses each year. Plant diseases cost the world economy more than $220 billion per year while invading insects cost at least $70 billion [148].
Pesticides are chemical compounds that are used to prevent or control pests. However, these are poisonous compounds that pollute soil, watercourses, and plant life. The inappropriate application and overuse of such chemicals have triggered numerous problems (e.g., the emergence of resistance in target organisms, food contamination, and environmental pollution) [149]. Pesticide use causes morphological, physiological, biochemical, and molecular changes in plants that can have a detrimental effect on the plant’s development and growth, leaving chemical residues in numerous plant tissues, as well as insect resistance to pesticides [150, 151]. Besides, pesticides cause oxidative stress in plants, hinder physiological and biochemical pathways, cause toxicity, obstruct photosynthesis, and reduce crop yield. The overgeneration of reactive oxygen species has a negative effect on non-targeted plants. Reactive oxygen species are highly reactive in nature, causing oxidative damage to lipids, nucleic acids, proteins, carbohydrates, and DNA in plants, as well as disruptions in other biochemical and physiological cell processes [152].
The rising number and intensity of pesticide consumption have presented a significant obstacle to the pests being targeted, leading them to disseminate to dynamic habitats and/or adjust to the changing settings [153]. Resistance is currently the greatest serious impediment to the effective use of pesticides. Many pest species have developed resistance to pesticides as a result of their use around the World [154].
Pesticides’ impact on non-target species has been a source of debate and worry around the world for decades. Pesticides’ adverse impacts on non-target arthropods have been well documented [155]. Natural insect adversaries, such as parasitoids and predators, are tragically the most vulnerable to insecticides and suffer the most harm [156]. Natural enemies that ordinarily keep small pests in check are sometimes harmed, which can lead to subsequent pest outbreaks.
Not just that, pesticide use may have a negative impact on the earthworm population. Earthworms contribute to the improvement and maintenance of soil structure by producing channels in the soil that allow for aeration and drainage. In agricultural settings, they are regarded as a key indicator of soil quality [157]. Earthworms are harmed by a wide range of agricultural practices, with indiscriminate pesticide usage being one of the most serious [158]. Yasmin and D’Souza [159] found that pesticides have a dose-dependent effect on earthworm reproduction and proliferation.
Moreover, pesticide usage has the potential to destroy biodiversity. Degraded pesticides interface with the soil as well as its inhabitants, affecting microbial diversity, biochemical processes, and enzyme activity [160]. Any change in the activity of soil microorganisms as a result of pesticide application disrupts the ecological environment, resulting in a loss of soil quality. In crops cultivated on soils excessively exposed to chemical pesticides, nutrient loss and disease incidence are widespread [161], which is unfavorable from the perspective of agricultural soil management for food and nutritional security.
Exogenous pesticide residues may also alter the efficacy of beneficial root-colonizing microbes, such as fungi, bacteria, algae, and arbuscular mycorrhiza (AM), in soil by affecting their growth, and metabolic activity, among other things [162].
Furthermore, pesticides are widely distributed when they are transported across long distances by air or water [163]. Several pesticides have a prolonged half-life (up to years) in the environment; for example, the half-life of HCH in water is determined to be 191 days [164], hence posing a threat to aquatic creatures.
The mode of pesticides’ action is hazardous not just to the target organisms but also to non-target creatures, such as humans. The physicochemical parameters of the active ingredient are known to influence pesticide diffusion into plant tissue. As a result, pesticides with a systemic effect are absorbed by the roots or leaves and transported throughout the plant, as a result, they pose a major health risk to anyone who consumes them [165]. Pesticides’ negative impacts on human health have begun to emerge as a result of their toxicity, longevity in the environment, and tendency to penetrate the food chain. Based on the side effects, chemical pesticides employed in crop protection to limit the damage caused by pathogens and pests in agricultural areas pose significant long-term risks and challenges to life forms. Pesticides can penetrate the human body through immediate exposure to chemicals, contaminated water, or polluted air, as well as through food, particularly fruits and vegetables. Pesticide exposure can cause both acute and chronic disorders. Humans develop chronic sickness after being exposed to sub-lethal levels of pesticides for extended periods of time [166]. They are believed to stimulate cancer [167] and fetal malformations [168], and they are nonbiodegradable [169]. Encountering pesticides with genetic makeup, resulting in DNA damage and chromosomal abnormalities, is one of the primary pathways that lead to chronic disorders, such as cancer [170]. Pesticides can also cause oxidative stress by modifying the amounts of antioxidant enzymes, including glutathione reductase, superoxide dismutase, and catalase, which increase reactive oxygen species (ROS) [171]. Pesticide-induced oxidative stress has been linked to a number of health concerns, including Parkinson’s disease and glucose homeostasis disruption [170].
Given the pervasive harmful effects of pesticides on plants, soil, the environment, and human health, an environmentally friendly replacement is required, making PGPR a viable option.
Biocontrol agents are bacteria that suppress the occurrence or severity of plant diseases, whereas antagonists are bacteria that have antagonistic behavior toward a pathogen. PGPR can be used as a biocontrol agent (Figure 3) to protect plants from pathogens, such as viruses, bacteria, insects, and fungi [173].
PGPR as biocontrol agent [
When compared to chemical pesticides, PGPR has unique benefits, including being harmless to mankind and nature, dissolving more quickly in soil, and having a lesser possibility of pathogen resistance development [174]. Because plants, unlike animals, are unable to use avoidance and escape as stress-relieving strategies, their existence has been marked by the establishment of extraordinarily favorable partnerships with their more mobile partners, microbes. PGPR and its interactions with plants are economically harnessed [175], and they hold considerable promise for long-term agricultural sustainability. Plants that have been inoculated by immersing their roots or seeds in PGPR cultures overnight have been shown to be extremely resistant to many forms of biotic stress [176].
Antibiotic synthesis is one of the most robust and well-studied biocontrol mechanisms of PGPR against phytopathogens during the last two decades [177]. Antibiotics are low-molecular-weight toxins that have the ability to kill or inhibit the growth of other bacteria. The Bacillus genus and Rhizobacteria are the most significant for antibiotic synthesis [178]. Antibacterial and antifungal antibiotics are produced by Bacillus amyloliquefaciens and B. subtilis, including subtilin, bacilysin, and emicobacillin [179].
Induced systemic resistance (ISR) is a physiological condition of increased defensive capacity triggered by a specific environmental stimulation. Conrath et al. [180] define ISR as “an enhanced defensive ability of plants in response to specific pathogens stimulated by beneficial microorganisms present in the rhizosphere,” a scenario wherein the interaction of certain microorganisms with roots results in plant tolerance to pathogenic bacteria, fungi, and viruses. ISR can also be induced by certain environmental cues that cause upregulation of plants’ innate defenses in response to the biotic assault, allowing plants to respond faster and stronger to subsequent pathogen attacks [181]. Following the pathogenic invasion, signals are produced, and a defense mechanism is activated via the vascular system. Among the defense mechanisms produced by ISR in plants are cell wall reinforcement [182], production of secondary metabolites, and accumulation of defense-related enzymes, such as chitinases, glucanases, peroxidase, phenylalanine ammonia-lyase, and polyphenol oxidase, lipoxygenase, SOD, CAT, and APX along with some proteinase inhibitors [183].
ISR is not unique to a particular pathogen but can benefit a plant by evading a variety of diseases. Various plants develop systemic resistance to a wide range of plant diseases and a variety of environmental stresses when primed with PGPR [184]. ISR is among the pathways through which PGPR might minimize the onset of various plant diseases by modifying the physical and biochemical attributes of host plants and thereby boosting plant growth [185]. After applying plant-growth-promoting rhizobacteria, diseases of fungal, bacterial, and viral origin, as well as damage caused by insects and nematodes, can be decreased [186].
Non-pathogenic microorganisms promote ISR, which starts in the roots and extends to the shoots [187]. ISR stimulates plant defense mechanisms and shields unexposed regions of plants against future pathogenic attacks by microbes and insects. The signaling of ethylene and jasmonic acid in the plant is involved in induced systemic resistance, and these hormones increase the host plant’s defense responses against a range of plant diseases [188]. Lipopolysaccharides (LPS), siderophores, homoserine lactones, 2, 4-diacetylphloroglucinol, cyclic lipopeptides, and volatiles like acetoin and 2, 3-butanediol are only a few of the bacterial components that cause induced systemic resistance [189].
Plant-growth-promoting rhizobacteria use another mechanism to promote growth—enzymatic activity, producing compounds that inhibit phytopathogenic agents [190]. Rhizobacterial strains that promote plant growth can secrete enzymes, including ACC-deaminase, phosphatases, chitinases, 1,3-glucanase, proteases, dehydrogenases, and lipases, among others [94, 191]. They excrete cell wall hydrolases, which are used to break down cell walls, neutralize infections, assault pathogens, and cause hyperparasitic activity [192]. Plant-growth-promoting rhizobacteria suppress pathogenic fungi, such as
In recent years, microbial volatile organic compounds (mVOC) have been shown to play an important role in microorganism–plant interactions [196, 197, 198]. VOCs are produced by a wide range of soil microorganisms. Bacillus bacteria are the most common microbes that produce antimicrobial MVOCs. Bacterial volatiles have a key function in encouraging plant growth by regulating phytohormone synthesis and metabolism.
They can also promote plant health by acting as antibacterial, nematicidal, oomyceticidal, and antifungal agents, as well as eliciting plant immunity via the salicylic acid (SA) and jasmonic acid (JA) pathways [199]. These molecules have the potential to increase plant growth and development and induce systemic resistance (ISR) against pathogenic organisms, resulting in improved agricultural well-being [200]. Through the SA-signaling pathway, acetoin from the bacteria B. subtilis produces systemic resistance in
Depending on the species, the quantity and composition of VOCs varies [202]. 2, 3-Butanediol is a volatile organic compound (VOC) generated by a variety of microorganisms that, among other things, can activate plant resistance against pathogens. This mVOC generated by
The antagonistic activity of PGPR also results in the production of volatile compounds. HCN, a well-studied biocontrol agent, commonly known as prussic acid, is a broad-spectrum volatile secondary metabolite generated by numerous rhizobacteria and is crucial for the biological control of several infectious microorganisms in the soil. Most metalloenzymes are inhibited by their cyanide ion, particularly copper-containing cytochrome c oxidases [204]. HCN-producing Pseudomonas strains are employed in the biological control of tomato bacterial canker [205]. For instance, the inhibition of Macrophomina phaseolina and Meloidogyne javanica caused sunflower charcoal rot and tomato root-knot diseases and has been related to bacterial strains secreting HCN [206]. The inhibitory activity process starts in the mitochondria, where HCN inhibits electron transport, reducing energy supply to the cell and finally causing pathogenic organisms to die.
Plants generate a lot of “stress ethylene” (ET) after the onset of a disease or stress. Much of the growth inhibition that happens as a result of environmental stress is due to the plant’s response to elevated levels of stress ethylene, which aggravates the stressor’s response. Likewise, ethylene production inhibitors can considerably reduce the intensity of various environmental stressors. The production of defense enzymes, including 1-aminocyclopropane-1-carboxylate (ACC) deaminase, has also been linked to PGPM’s ability to protect against biotic stress [207]. Numerous results suggest that seed inoculation with bacterial endophytes increases plant defense. This is because bacteria produce the enzyme 1-aminocyclopropane-1-carboxylate (ACC), which can cleave ET into ketobutyrate and ammonia, lowering the presence of this enzyme linked to plant stress and physiological impairment [208]. As a result, if ACC deaminase-containing bacteria can reduce plant ethylene levels, treating plants with these organisms may give some defense against the stress inhibitory effects. The synthesis of ACC-deaminase by
To meet the ever-increasing nutritional demand of the rapidly increasing world population, chemical fertilizers must be employed. However, unintended and excessive use has a variety of negative repercussions on the natural environment resulting in soil degradation, global warming, and climate change, necessitating the search for environmentally sound alternatives. PGPR, in this regard, is a realistic choice for agricultural production that does not deplete natural resources. Plants and microbial communities in the soil have evolved a variety of biotic connections, ranging from commensalism to mutualism. Plant-PGPR collaboration is an important aspect of this web of interactions, promoting the growth and health of a variety of plants. PGPR has recently received a lot of attention for its potential to replace agrochemicals for plant growth and yield through a variety of processes, including decomposition of organic matter, recycling of essential elements, formation of soil structure, production of numerous plant growth regulators, fixation of atmospheric nitrogen, degradation of organic pollutants, stimulation of root growth, solubilization of phosphorus, production of siderophore, and solubilization of mineral nutrients, all of which are important for soil and plant health. Furthermore, they are cost-efficient and environmentally sustainable and assure that nutrients from natural sources are always accessible. Besides, bacterial colonies in the rhizosphere have a considerable impact on phytopathogenic microorganism reduction, in addition to boosting plant growth through active processes, hence the use of phytomicrobiome representatives in farming production as long-term disease prevention and nutrient supplement strategy could also help to mitigate the detrimental effects of pesticide use.
As a nutshell, in the face of global climate change, PGPR could be a more environmentally friendly option than chemical fertilizers.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. 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It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations. The antimicrobial activity of this product is highly complex. Generation of hydrogen peroxide, bee defensin-1, high osmolarity and low value of pH seems to be crucial for its antimicrobial potential. Considering honey as a therapeutic, antimicrobial agent special attention deserves Manuka honey. Its high antimicrobial activity is caused by high concentration of 1,2-dicarbonyl compound methylglyoxal. Some authors also suggest that other phytochemicals, especially phenolic compounds, are important antibacterial ingredients of honey. The results of many in vitro but also in vivo studies confirm high antimicrobial potential of honey against some important human and veterinary pathogens: Staphylococcus aureus, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Escherichia coli. We do not have doubts that honey, but also other bee products, especially propolis, is promising antimicrobial agents and possibilities of their application in clinical medicine deserve consideration.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Piotr Szweda",authors:[{id:"117528",title:"Dr.",name:"Szweda",middleName:null,surname:"Piotr",slug:"szweda-piotr",fullName:"Szweda Piotr"}]},{id:"54195",doi:"10.5772/67262",title:"Microorganisms in Honey",slug:"microorganisms-in-honey",totalDownloads:3960,totalCrossrefCites:12,totalDimensionsCites:20,abstract:"Honey is a product with low water activity because of the great amount of sugars (fructose and glucose), and also it has antimicrobial compounds derived from flowers or because of its transformation process in the beehive. Despite all the honey microorganism barriers, some species of microorganisms are able to survive and may cause damage to honeybees or consumers. Techniques of pathogenic microorganism identification by DNA using PCR are recommended and required for sanitary and customs control. It is important to know the diversity of contaminating microorganisms in honey, especially due to disseminate pathogenic microorganisms in the international traded marketing. In contrast, beneficial microorganisms such as yeasts can remain latently in this product waiting for the moment in which the environment is suitable for their development. Among the beneficial bacteria found in honeybee products, we can mention some lactic acid bacteria that act as prebiotics when ingested. The microorganisms in the digestive tract of honeybees are important for their health. Thus, we present the knowledge of microbiota associated with honey from honeybees and stingless bees (Hymenoptera, Apidae) and the techniques available for the detection of microorganisms in honey.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Mayara Salgado Silva, Yavor Rabadzhiev, Monique Renon Eller, Ilia\nIliev, Iskra Ivanova and Weyder Cristiano Santana",authors:[{id:"192986",title:"Dr.",name:"Weyder Cristiano",middleName:null,surname:"Santana",slug:"weyder-cristiano-santana",fullName:"Weyder Cristiano Santana"},{id:"197594",title:"MSc.",name:"Mayara",middleName:null,surname:"Salgado-Silva",slug:"mayara-salgado-silva",fullName:"Mayara Salgado-Silva"},{id:"197595",title:"Dr.",name:"Yavor",middleName:null,surname:"Rabadzhiev",slug:"yavor-rabadzhiev",fullName:"Yavor Rabadzhiev"},{id:"197596",title:"Prof.",name:"Monique",middleName:null,surname:"Eller",slug:"monique-eller",fullName:"Monique Eller"},{id:"197597",title:"Prof.",name:"Iskra",middleName:null,surname:"Ivanova",slug:"iskra-ivanova",fullName:"Iskra Ivanova"},{id:"197598",title:"Prof.",name:"Ilia",middleName:null,surname:"Iliev",slug:"ilia-iliev",fullName:"Ilia Iliev"}]},{id:"53469",doi:"10.5772/66839",title:"Techniques for the Evaluation of Physicochemical Quality and Bioactive Compounds in Honey",slug:"techniques-for-the-evaluation-of-physicochemical-quality-and-bioactive-compounds-in-honey",totalDownloads:3850,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Honey is a concentrated aqueous solution of sugar, especially glucose and fructose, and minor amounts of dextrin, enzymes, waxes, volatile oils, organic acids, ethers, albuminoidal gum substances and minerals. Commercially available honey samples vary in quality according to various factors such as climate diversity, type of flora of the surrounding region, geographical characteristics, processing, floral supply period, and packaging and storage conditions, which can compromise the standardization and quality of the final product. The different techniques that will be presented in this chapter to assess the quality of honey are tests required by identification standards and national and international quality control or are important quality tools that can be used in the evaluation of the conditions for obtaining and processing of the honey, fraud identification and changes to and/or adulteration of the honey, ensuring the physical and chemical composition of the project and guaranteeing quality standards, directly impacting the shelf life and use and presentation of the product.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Maria Josiane Sereia, Paulo Henrique Março, Marcia Regina Geraldo\nPerdoncini, Rejane Stubs Parpinelli, Erica Gomes de Lima and\nFernando Antônio Anjo",authors:[{id:"192188",title:"Dr.",name:"Maria",middleName:null,surname:"Sereia",slug:"maria-sereia",fullName:"Maria Sereia"}]},{id:"53417",doi:"10.5772/66590",title:"Production and Trade of Honey in Selected European Countries: Serbia, Romania and Italy",slug:"production-and-trade-of-honey-in-selected-european-countries-serbia-romania-and-italy",totalDownloads:2182,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The beekeeping sector is very complex, because of not onlythe diversity of bee products obtained but also the environmental services through pollination. Even if its direct impact on domestic economy and trade varies across countries, at micro-level, beekeeping creates well-being for communities, providing health products for population and decent revenues for farmers. It also supports the sustainability of rural livelihoods. In this context, the research subject is the analysis of production and trade of honey in three European Union Countries—Romania, Italy and Serbia—with a goal to consider the dynamic of supply and trade of honey and deduce potential opportunities for producers. The goal of the study is to draw implication from the results obtained, suggesting the concrete measures to improve the existing situation. Trade data are examined to get a picture of honey sector trends. An entire set of trade indicators related to honey were computed over the period 2006–2015 and are presented in the chapter: value, amount, growth rate and geographic structure of export and import in the world and in selected countries for which the level of comparative advantages of exported honey was also measured using the Balassa index.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Cristina Bianca Pocol, Svetlana Ignjatijević and Daniele Cavicchioli",authors:[{id:"190657",title:"Dr.",name:"Svetlana",middleName:null,surname:"Ignjatijević",slug:"svetlana-ignjatijevic",fullName:"Svetlana Ignjatijević"},{id:"192970",title:"Associate Prof.",name:"Cristina Bianca",middleName:null,surname:"Pocol",slug:"cristina-bianca-pocol",fullName:"Cristina Bianca Pocol"},{id:"192971",title:"Dr.",name:"Daniele",middleName:null,surname:"Cavicchioli",slug:"daniele-cavicchioli",fullName:"Daniele Cavicchioli"}]},{id:"53775",doi:"10.5772/67020",title:"Honey as a Functional Food",slug:"honey-as-a-functional-food",totalDownloads:2192,totalCrossrefCites:5,totalDimensionsCites:10,abstract:"The most well‐known functional properties of honey are its antioxidant and antimicrobial activities. The bioactive components of honey are affected by the flora from which it is produced and by geographical variations. Phenolic compounds promote, among other activities, high antioxidant action, being capable of minimizing intracellular oxidative damage associated with cellular aging, apoptosis and neurodegenerative diseases. A living cell system would provide a better platform for determining antioxidant activity, since the bioactive honey compounds can act modulating antioxidant defense gene expression. Indeed, phenolic compounds, amino acids and reducing sugars are among the substances responsible for honey antioxidant activity. Most of phenolic compounds also exert antimicrobial activity against a number of pathogens and spoilage microorganisms. The antimicrobial activity of honey is also due to the action of enzymes. In addition, honey was found to contain lactic acid bacteria (LAB), which itself produce a myriad of active compounds that remain in variable amounts in mature honey. In addition, these antioxidant compounds might play a key role as prebiotic, protecting and stimulating growth of probiotic bacteria. Oligosaccharides present in honey are well‐known prebiotic substances stimulating growth, activity and protecting probiotic bacteria during passage through the gastrointestinal tract and during storage of the products. This chapter describes the main bioactive components of honey, especially with respect to the phenolic compounds and their antioxidant activity and assay methods.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Rosa Helena Luchese, Edlene Ribeiro Prudêncio and André\nFioravante Guerra",authors:[{id:"191671",title:"Ph.D.",name:"Rosa",middleName:null,surname:"Luchese",slug:"rosa-luchese",fullName:"Rosa Luchese"},{id:"192130",title:"MSc.",name:"Edlene",middleName:null,surname:"Prudêncio",slug:"edlene-prudencio",fullName:"Edlene Prudêncio"},{id:"192133",title:"MSc.",name:"André",middleName:null,surname:"Guerra",slug:"andre-guerra",fullName:"André Guerra"}]}],mostDownloadedChaptersLast30Days:[{id:"54003",title:"Antimicrobial Activity of Honey",slug:"antimicrobial-activity-of-honey",totalDownloads:4356,totalCrossrefCites:10,totalDimensionsCites:24,abstract:"Honey has had a valued place in traditional medicine for centuries. It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations. The antimicrobial activity of this product is highly complex. Generation of hydrogen peroxide, bee defensin-1, high osmolarity and low value of pH seems to be crucial for its antimicrobial potential. Considering honey as a therapeutic, antimicrobial agent special attention deserves Manuka honey. Its high antimicrobial activity is caused by high concentration of 1,2-dicarbonyl compound methylglyoxal. Some authors also suggest that other phytochemicals, especially phenolic compounds, are important antibacterial ingredients of honey. The results of many in vitro but also in vivo studies confirm high antimicrobial potential of honey against some important human and veterinary pathogens: Staphylococcus aureus, Helicobacter pylori, Mycobacterium tuberculosis, Pseudomonas aeruginosa and Escherichia coli. We do not have doubts that honey, but also other bee products, especially propolis, is promising antimicrobial agents and possibilities of their application in clinical medicine deserve consideration.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Piotr Szweda",authors:[{id:"117528",title:"Dr.",name:"Szweda",middleName:null,surname:"Piotr",slug:"szweda-piotr",fullName:"Szweda Piotr"}]},{id:"53469",title:"Techniques for the Evaluation of Physicochemical Quality and Bioactive Compounds in Honey",slug:"techniques-for-the-evaluation-of-physicochemical-quality-and-bioactive-compounds-in-honey",totalDownloads:3850,totalCrossrefCites:8,totalDimensionsCites:17,abstract:"Honey is a concentrated aqueous solution of sugar, especially glucose and fructose, and minor amounts of dextrin, enzymes, waxes, volatile oils, organic acids, ethers, albuminoidal gum substances and minerals. Commercially available honey samples vary in quality according to various factors such as climate diversity, type of flora of the surrounding region, geographical characteristics, processing, floral supply period, and packaging and storage conditions, which can compromise the standardization and quality of the final product. The different techniques that will be presented in this chapter to assess the quality of honey are tests required by identification standards and national and international quality control or are important quality tools that can be used in the evaluation of the conditions for obtaining and processing of the honey, fraud identification and changes to and/or adulteration of the honey, ensuring the physical and chemical composition of the project and guaranteeing quality standards, directly impacting the shelf life and use and presentation of the product.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Maria Josiane Sereia, Paulo Henrique Março, Marcia Regina Geraldo\nPerdoncini, Rejane Stubs Parpinelli, Erica Gomes de Lima and\nFernando Antônio Anjo",authors:[{id:"192188",title:"Dr.",name:"Maria",middleName:null,surname:"Sereia",slug:"maria-sereia",fullName:"Maria Sereia"}]},{id:"53175",title:"Analytical Procedures for Determining Heavy Metal Contents in Honey: A Bioindicator of Environmental Pollution",slug:"analytical-procedures-for-determining-heavy-metal-contents-in-honey-a-bioindicator-of-environmental-",totalDownloads:3699,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"Metals are pollutant residues detectable in honey and in fact account for most of the inorganic pollutants found in this food product. Metal pollutants can be accumulated through the food chain and, at levels exceeding safe thresholds, can be toxic to humans and even damage physiological functions. During the honey-making process, bees can transport pollutants to the beehive following contact with polluted botanic species or from drinking contaminated water. Detecting very low concentrations is a persisting challenge to accurately measure these elements in honey. Additionally, since honey is a complex organic matrix, treatments are needed prior to applying any classical chemical methods for metal determination, such as inductively coupled plasma and atomic absorption spectroscopy. Therefore, optimal results are dependent on adequate sample conditioning prior to heavy metal content analyses. Chemical pretreatments include calcination processes and/or acid digestion. Regarding execution, the last steps of any metal detection methodology are the primary determinants of result quality, where any loss of mass is reflected by unreliable values.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Enrique Mejías and Tatiana Garrido",authors:[{id:"191583",title:"Dr.",name:"Enrique",middleName:null,surname:"Mejias",slug:"enrique-mejias",fullName:"Enrique Mejias"},{id:"193079",title:"Dr.",name:"Tatiana",middleName:null,surname:"Garrido",slug:"tatiana-garrido",fullName:"Tatiana Garrido"}]},{id:"53895",title:"Rheological Properties of Honey in a Liquid and Crystallized State",slug:"rheological-properties-of-honey-in-a-liquid-and-crystallized-state",totalDownloads:2360,totalCrossrefCites:4,totalDimensionsCites:6,abstract:"The rheological properties of honey are discussed separately for liquid and crystallized honey. The research methods used in both cases are characterized. The basic mathematical models are shown, which describe the viscosity of honey in its liquid form depending on temperature and water content. In the case of crystallized honey, the rheological properties were linked to morphological features and crystalline phase content. Results of characteristic experiments are presented, obtained during the shearing of crystallized suspension, that is, crystallized honey. Among other items, the dependency of equilibrium stress on shear rate, apparent viscosity on crystalline phase content, hysteresis loops as evidence that honey in its crystallized form is a rheologically unstable fluid. Results of measurements under forced oscillation conditions are included and compared with results of rotational measurements. It was shown that the research method influences the obtained results of rheological studies.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Sławomir Bakier",authors:[{id:"192064",title:"Ph.D.",name:"Sławomir",middleName:null,surname:"Bakier",slug:"slawomir-bakier",fullName:"Sławomir Bakier"}]},{id:"53417",title:"Production and Trade of Honey in Selected European Countries: Serbia, Romania and Italy",slug:"production-and-trade-of-honey-in-selected-european-countries-serbia-romania-and-italy",totalDownloads:2182,totalCrossrefCites:3,totalDimensionsCites:10,abstract:"The beekeeping sector is very complex, because of not onlythe diversity of bee products obtained but also the environmental services through pollination. Even if its direct impact on domestic economy and trade varies across countries, at micro-level, beekeeping creates well-being for communities, providing health products for population and decent revenues for farmers. It also supports the sustainability of rural livelihoods. In this context, the research subject is the analysis of production and trade of honey in three European Union Countries—Romania, Italy and Serbia—with a goal to consider the dynamic of supply and trade of honey and deduce potential opportunities for producers. The goal of the study is to draw implication from the results obtained, suggesting the concrete measures to improve the existing situation. Trade data are examined to get a picture of honey sector trends. An entire set of trade indicators related to honey were computed over the period 2006–2015 and are presented in the chapter: value, amount, growth rate and geographic structure of export and import in the world and in selected countries for which the level of comparative advantages of exported honey was also measured using the Balassa index.",book:{id:"5520",slug:"honey-analysis",title:"Honey Analysis",fullTitle:"Honey Analysis"},signatures:"Cristina Bianca Pocol, Svetlana Ignjatijević and Daniele Cavicchioli",authors:[{id:"190657",title:"Dr.",name:"Svetlana",middleName:null,surname:"Ignjatijević",slug:"svetlana-ignjatijevic",fullName:"Svetlana Ignjatijević"},{id:"192970",title:"Associate Prof.",name:"Cristina Bianca",middleName:null,surname:"Pocol",slug:"cristina-bianca-pocol",fullName:"Cristina Bianca Pocol"},{id:"192971",title:"Dr.",name:"Daniele",middleName:null,surname:"Cavicchioli",slug:"daniele-cavicchioli",fullName:"Daniele Cavicchioli"}]}],onlineFirstChaptersFilter:{topicId:"346",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA. Dr. Stavropoulos received her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. 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He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. 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She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorThree:null},{id:"90",title:"Human Development",coverUrl:"https://cdn.intechopen.com/series_topics/covers/90.jpg",isOpenForSubmission:!0,annualVolume:11974,editor:{id:"191040",title:"Dr.",name:"Tal",middleName:null,surname:"Dotan Ben-Soussan",slug:"tal-dotan-ben-soussan",fullName:"Tal Dotan Ben-Soussan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBf1QAG/Profile_Picture_2022-03-18T07:56:11.jpg",biography:"Tal Dotan Ben-Soussan, Ph.D., is the director of the Research Institute for Neuroscience, Education and Didactics (RINED) – Paoletti Foundation. 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Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}]},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. 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He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}]},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",biography:"Dr. Kasenga is a graduate of Tumaini University, Kilimanjaro Christian Medical College, Moshi, Tanzania and Umeå University, Sweden. He obtained a Master’s degree in Public Health and PhD in Public Health and Epidemiology. He has a background in Clinical Medicine and has taken courses at higher diploma levels in public health from University of Transkei, Republic of South Africa, and African Medical and Research Foundation (AMREF) in Nairobi, Kenya. Dr. Kasenga worked in different places in and outside Malawi, and has held various positions, such as Licensed Medical Officer, HIV/AIDS Programme Officer, HIV/AIDS resource person in the International Department of Diakonhjemet College, Oslo, Norway. He also managed an Integrated HIV/AIDS Prevention programme for over 5 years. He is currently working as a Director for the Health Ministries Department of Malawi Union of the Seventh Day Adventist Church. Dr. Kasenga has published over 5 articles on HIV/AIDS issues focusing on Prevention of Mother to Child Transmission of HIV (PMTCT), including a book chapter on HIV testing counseling (currently in press). 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Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. 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Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"11",type:"subseries",title:"Cell Physiology",keywords:"Neurodevelopment and Neurodevelopmental Disease, Free Radicals, Tumor Metastasis, Antioxidants, Essential Fatty Acids, Melatonin, Lipid Peroxidation Products and Aging Physiology",scope:"\r\n\tThe integration of tissues and organs throughout the mammalian body, as well as the expression, structure, and function of molecular and cellular components, is essential for modern physiology. The following concerns will be addressed in this Cell Physiology subject, which will consider all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and their interactions: (1) Neurodevelopment and Neurodevelopmental Disease (2) Free Radicals (3) Tumor Metastasis (4) Antioxidants (5) Essential Fatty Acids (6) Melatonin and (7) Lipid Peroxidation Products and Aging Physiology.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"186048",title:"Prof.",name:"Ines",middleName:null,surname:"Drenjančević",slug:"ines-drenjancevic",fullName:"Ines Drenjančević",profilePictureURL:"https://mts.intechopen.com/storage/users/186048/images/5818_n.jpg",institutionString:null,institution:{name:"University of Osijek",institutionURL:null,country:{name:"Croatia"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"79615",title:"Dr.",name:"Robson",middleName:null,surname:"Faria",slug:"robson-faria",fullName:"Robson Faria",profilePictureURL:"https://mts.intechopen.com/storage/users/79615/images/system/79615.png",institutionString:null,institution:{name:"Oswaldo Cruz Foundation",institutionURL:null,country:{name:"Brazil"}}},{id:"84459",title:"Prof.",name:"Valerie",middleName:null,surname:"Chappe",slug:"valerie-chappe",fullName:"Valerie Chappe",profilePictureURL:"https://mts.intechopen.com/storage/users/84459/images/system/84459.jpg",institutionString:null,institution:{name:"Dalhousie University",institutionURL:null,country:{name:"Canada"}}}]},onlineFirstChapters:{paginationCount:26,paginationItems:[{id:"82112",title:"Comparative Senescence and Lifespan",doi:"10.5772/intechopen.105137",signatures:"Hassan M. 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