Marwa El-Azazy

By Marwa S. Elazazy

Pharmaceutical analysis is going through an expeditious progress as the perception of ‘multivariate data analysis’ (MVA) becomes gradually more assimilated. Pharmaceutical analysis comprises a range of processes that covers both chemical and physical assessment of drugs and their formulations employing different analytical techniques. With the revolution in instrumental analysis and the huge amount of information produced, there must be an up-to-date data processing tool. The role of chemometrics then comes up. Multivariate analysis (MVA) has the capability of effectively drawing a complete picture of the investigated process. Moreover, MVA reproduces the arithmetic influence of variables and their interactions through a smaller number of trials, keeping both efforts and capitals. Spectrophotometry is among the most extensively used techniques in pharmaceutical analysis either direct (single component) or derivative (multicomponent). In addition to these recognized benefits, using chemometrics in conjunction with spectrophotometry affects three vital characteristics: accuracy, precision and robustness. The impact of hyphenation of spectrophotometric analytical techniques to chemometrics (experimental design and support vector machines) on analytical laboratory will be revealed. A theoretical background on the different factorial designs and their relevance is provided. Readers will be able to use this chapter as a guide to select the appropriate design for a problem.

Part of the book: Spectroscopic Analyses

By Marwa S. El-Azazy

Chemical measurement processes (CMPs) must be performed in a setup of controlled statistical conditions. Thus, validation of such a measurement process and assessment of its ability to accurately measure the analyte is important. Analytical calibration is the most crucial step in any analytical procedure targeting the estimation of analyte concentration. As a key component of any validation procedure, calibration must be properly conducted. To achieve that, firm knowledge with the realms of the calibration process must exist. Several jurisdictions help to build up this acquaintance, including the terminology and definitions, the international guidelines and how they differ, schemes and manuals to be used to build a calibration model, metrological considerations, and assessment procedures. Careful thinking prior to any of the previous calibration aspects is necessary and helps to improve the product of the calibration process. Throughout this chapter, aspects of the calibration assembly will be thoroughly discussed. Different types of calibration will be revealed with a focus on analytical calibration for a CMP. Steps for a successful calibration will be described. The reader will be able to use information given throughout this chapter as a guide for an effective calibration process.

Part of the book: Calibration and Validation of Analytical Methods

By Marwa El-Azazy

Part of the book: Infrared Spectroscopy

By Ahmed El-Gendy, Ahmed S. El-Shafie, Ahmed Issa, Saeed Al-Meer, Khalid Al-Saad and Marwa El-Azazy

The widespread use of antimicrobials within either a therapeutic or a veterinary rehearsal has resulted in a crisis on the long run. New strains of antimicrobial-resistant microorganisms have appeared. Contamination of water with pharmaceutically active materials is becoming a fact! and efficacy of wastewater treatment plants is a question. Adsorption is a promising technique for wastewater treatment. Carbon-based materials are among the most commonly used adsorbents for remediation purposes. Food production and commercialization are posing rigorous regulations. In this concern, almost all authoritarian societies are setting up standards for the maximum residue levels permissible in raw and processed food. Among these products is infant foods. The current trend is to use carbon-based and recycled from agricultural wastes, which can selectively remove target antimicrobials. Nanoparticles are among the most commonly used materials. With the enormous amount of data generated from an analytical process, there is a need for a powerful data processing technique. Factorial designs play an important role in not only minimalizing the number of experimental runs, and hence saving chemicals, resources, and reducing waste but also, they serve to improve the sensitivity and selectivity, the most important analytical outcomes.

Part of the book: Carbon-Based Material for Environmental Protection and Remediation

By Marwa El-Azazy

Electrochemical impedance spectroscopy (EIS) is a potent electrochemical technique with a variety of applications. EIS measurements involve the application of an alternating current (AC) voltage (or current) to the system under investigation, followed by measurement of the response in the form of AC current (or voltage) as a function of frequency. By and large, EIS is an exceptionally attractive in terms of applications. Being nondestructive with a feasibility of implementation to the system to be measured and the usefulness of data obtained in characterizing the studied systems, electrochemical impedance spectroscopy has realms of applications. As food and water safety and security is becoming a universal concern, the need for a technique that can detect water and food contaminants with relatively high sensitivity and selectivity is evolving. EIS has started to realize its potential with a wide-term use in water and food analyses.

Part of the book: Electrochemical Impedance Spectroscopy

By Marwa El-Azazy, Ahmed S. El-Shafie and Khalid Al-Saad

Global economies are confronting major energy challenges. Mitigating the energy depletion crisis and finding alternative and unconventional energy sources have been subjects for many investigations. Plant-sourced biomasses have started to attract global attention as a renewable energy source. Maximizing the performance of the biomass feedstock in different applications requires the availability of reliable and cost-effective techniques for characterization of the biomass. Comprehending the structure of lignocellulosic biomass is a very important way to assess the feasibility of bond formation and functionalization, structural architecture, and hence sculpting of the corresponding structure−property liaison. Over the past decades, non-invasive techniques have brought many pros that make them a valuable tool in depicting the structure of lignocellulosic materials. The current chapter will be focused on the applications of Fourier transform infrared (FTIR) spectroscopy especially in the mid-infrared region in the compositional and structural analysis of lignocellulosic biomasses. The chapter will provide a display of examples from the literature for the application of FTIR spectroscopy in finding the composition of various biomasses obtained from different parts of plants and applied for wastewater treatment. A comparison between biomasses and physically/chemically treated products will be discussed.

Part of the book: Infrared Spectroscopy

By Marwa El-Azazy, Ahmed S. El-Shafie and Khalid Al-Saad

Part of the book: Infrared Spectroscopy