4(3H)-Quinazolinone derivatives have considerable great interesting due to the diverse range of their biological properties. This review summarized the methods of preparation of 2-substituted-4(3H)-quinazolinone, 3-substituted-4(3H)-quinazolinone and 2,3-disubstituted-4(3H)-quinazolinone derivatives. Chemical reaction of 4(3H)-quinazolinone derivatives and the reactivity of the 2-methyl group, reactivity of the 3-amino group, electrophilic substitution, oxidation, reduction, reaction of 4(3H)-quinazolinones with metal ions, Mannich reaction, cycloaddition reaction as well as other reagents were discussed. Also, biological properties of 4(3H)-quinazolinone derivatives were given herein.
Part of the book: Quinazolinone and Quinazoline Derivatives