The fatty acid de novo synthesized in mammary gland is mainly catalyzed by fatty acid synthase (FASN) and acetyl CoA carboxylase (ACC), including all the short- and medium-chain fatty acid and half part of the palmitate in ruminants. However, the synthesis mechanism of medium-chain fatty acid among different species is different. In non-ruminants, a tissue-specific enzyme thioesterase II (TE II) can interact with TE I, which is a part of FASN, and terminate the elongation of fatty acids at about 10 carbons. However, in ruminants’ mammary-gland acetyl/malonyl-CoA transferase (MAT) is predicted to be involved in the termination of medium-chain fatty acid without the presence of (TE II). A more exact understanding about the mechanism of synthesis of medium-chain fatty acid in different species is still unclear. This review gives the research development of synthesis mechanism of medium-chain fatty acid in mammary gland among different species.
Part of the book: Fatty Acids