Jeffrey S. Borer, M.D., is Professor of Medicine, Cell Biology, Radiology, Surgery and Public Health at the State University of New York Downstate Medical University. For many years he served as Chief, Division of Cardiovascular Medicine and, simultaneously, as Chairman, Department of Medicine, at SUNY Downstate, administrative positions he has now relinquished to concentrate on his work as Director of two research institutes at Downstate. Dr. Borer received a BA from Harvard, a M.D. from Cornell, trained at the Massachusetts General Hospital, spent 7 years in the Cardiology Branch, NHLBI, and a year at Guy’s Hospital (London) as Senior Fullbright Hays Scholar and Glorney-Raisbeck Fellow in the Medical Sciences, completing the first clinical demonstration of nitroglycerin’s utility in acute MI following his several years of preclinical studies at NIH. Upon returning to the NIH, he developed stress radionuclide cineangiography, enabling the first non-invasive assessment of cardiac function with exercise and importantly changing the practice of cardiology. He then returned to Cornell for 30 years as Gladys and Roland Harriman Professor of Cardiovascular Medicine and Chief, Division of Cardiovascular Pathophysiology. At Cornell and now at Downstate, he performs clinical service, teaching and research, the latter primarily developing prognosticators for regurgitant valve diseases, and assessing the effects of heart rate modification on clinical outcomes, with trials in coronary artery disease and heart failure. He has been an Advisor to the USFDA for 42 years, chaired the CardioRenal Drugs Advisory Committee for 3 terms and the Circulatory Devices Advisory Panel for one term, was a life sciences Advisor to NASA for 24 years, has served as officer/board member of several national professional societies (most recently founding President, Heart Valve Society of America 2004-2014, now expanded to the Heart Valve Society [international], of which he serves on the Board of Trustees), has published more than 500 scientific papers and 8 books, has participated in various roles in numerous clinical trials of therapies, for 14 years was editor-in-chief of the journal, Cardiology, and has received several awards and other recognitions for his work including, most recently, the Lifetime Achievement Award of the Heart Valve Society of America and Society of Heart Valve Disease of Europe (2014), his selection as one of three Legends of Cardiology at the 10th Annual Complex Catheter-based Cardiovascular Therapeutics conference (2014), and the Kanu Chatterjee Lifetime Award for Oustanding Contributions to the Field of Cardiovascular Medicine, International Academy of Cardiology (2018). His research has been supported by NIH, AHA and, for many years, by several large private foundations.