IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
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IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
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Designed to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
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After a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
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Our innovative Book Series format brings you:
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Topic Focused Publications - Each topic showcases high impact subject areas
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Renowned Editorial Expertise - Series Editors, Topic Editors, and a team of international Board Members that permanently support each Book Series
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Fast Publishing - quick turnaround which is unique for book publishing
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The benefit of ISSN and ISBN for increased citation and indexing possibilities
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\n\n\n\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\n
IntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
We invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
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Note: Edited in October 2021
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The book comprises single chapters authored by various researchers and is edited by a group of experts in such research areas. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on electric power conversion, micro-grids, and their up-to-the-minute technological advances and opens new possible research paths for further novel developments.",isbn:"978-1-83969-389-2",printIsbn:"978-1-83969-388-5",pdfIsbn:"978-1-83969-390-8",doi:"10.5772/intechopen.91563",price:119,priceEur:129,priceUsd:155,slug:"electric-power-conversion-and-micro-grids",numberOfPages:178,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"9f41084eff07323bda451cd5c77dfaaf",bookSignature:"Majid Nayeripour and Mahdi Mansouri",publishedDate:"January 26th 2022",coverURL:"https://cdn.intechopen.com/books/images_new/10377.jpg",numberOfDownloads:1066,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:1,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:1,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 27th 2020",dateEndSecondStepPublish:"December 28th 2020",dateEndThirdStepPublish:"February 23rd 2021",dateEndFourthStepPublish:"May 14th 2021",dateEndFifthStepPublish:"July 13th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"66929",title:"Prof.",name:"Majid",middleName:null,surname:"Nayeripour",slug:"majid-nayeripour",fullName:"Majid Nayeripour",profilePictureURL:"https://mts.intechopen.com/storage/users/66929/images/system/66929.png",biography:"After 8 years of industrial experience and academic work in the electrical engineering and renewable energy fields, Prof. Majid Nayeripour was promoted to full professor in the field of micro-grids in 2016. He was given a sabbatical from Shiraz University of Technology, Iran, and was invited to Cologne University of Applied Sciences, Germany in January 2016. During his research, he gained new experiences about problems relating to high penetration levels of distributed generations and toward having 100% renewable energy in Germany, and as a result, he was awarded a fellowship program for an experienced researcher from the Alexander von Humboldt (AvH) Foundation in 2017. Currently, he is at the Cologne University of Applied Science and is involved in research on the control and dynamic investigation of interconnected micro-grids. He has published more than 120 journals and conference papers, five books, and supervised more than ten research projects.",institutionString:"Cologne University of Applied Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"5",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"291302",title:"Dr.",name:"Mahdi",middleName:null,surname:"Mansouri",slug:"mahdi-mansouri",fullName:"Mahdi Mansouri",profilePictureURL:"https://mts.intechopen.com/storage/users/291302/images/system/291302.png",biography:"Dr. Mahdi Mansouri was born in Yazd, Iran in 1975. He received both his B.S. degree in electronic engineering and MSc degree in electronic power from the Sharif University of Technology at Power Electronics-STATCOM and his Ph.D. degree in renewable energy systems from doubly fed induction generator (DFIG)-based wind turbines from the Shiraz University of Technology. He has 20 years of experience in high-voltage transmission substations and lines as a technical engineer, a consultant, and an executive project manager. His research interests include flexible alternating current transmission system devices, power quality, and power system protection. He currently conducts power electronics, power-relay protection, and power-quality projects as a consultant and project manager.",institutionString:"Yazd University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"756",title:"Power Electronics",slug:"power-electronics"}],chapters:[{id:"77537",title:"Design and Simulation of Low-Cost Microgrid Controller in Off-Grid Remote Areas",doi:"10.5772/intechopen.98551",slug:"design-and-simulation-of-low-cost-microgrid-controller-in-off-grid-remote-areas",totalDownloads:335,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This study presents the microgrid controller with an energy management strategy for an off-grid microgrid, consisting of an energy storage system (ESS), photovoltaic system (PV), micro-hydro, and diesel generator. The aim is to investigate the improved electrical distribution and off-grid operation in remote areas. The off-grid microgrid model and the control algorithms developed using MATLAB Simulink and State flow. The energy management system is focusing on the state of charge of the energy storage system. The microgrid controller controls the operation mode and power generation from the distributed generations’ local controller, i.e., PV, micro-hydro, and diesel. It also controls the smart meters of the loads to be connected or disconnected to the microgrid. The simulation results show that the proposed microgrid control can control the target off-grid microgrid in given possible scenarios. The off-grid microgrid managed to meet the energy demand with the lowest power outage and the diesel generator operation’s lowest cost.",signatures:"Tapparit Bangtit",downloadPdfUrl:"/chapter/pdf-download/77537",previewPdfUrl:"/chapter/pdf-preview/77537",authors:[{id:"344060",title:"Mr.",name:"Tapparit",surname:"Bangtit",slug:"tapparit-bangtit",fullName:"Tapparit Bangtit"}],corrections:null},{id:"78818",title:"A Novel Energy Management Control Technique for PV-Battery System in DC Microgrids",doi:"10.5772/intechopen.98524",slug:"a-novel-energy-management-control-technique-for-pv-battery-system-in-dc-microgrids",totalDownloads:155,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This paper presents a new energy management control technique for PV-Battery system used in DC microgrids. The proposed control technique is performed based on a droop control algorithm that maintains DC-bus voltage in a desirable and required range adaptively. Tightly Regulating the bus voltage In the islanded mode of operation is very challenging. However, the proposed control method by introducing a nonlinear droop profile with four adaptive parameters shows its superiority. Adaptive parameters determined by the non-linear optimal algorithms. Tightly regulating the DC bus voltage during extensive changes in demand loads/sources within a DC Micro Grid is the responsibility of the adaptive parameters. Stability of the proposed method in the whole system for a very broad range of operating conditions are proved. Simulation results along with the experimental results verify the feasibility of the proposed approach while demonstrate its superior performance compared to the conventional control method.",signatures:"Hadis Hajebrahimi, Sajjad Makhdoomi Kaviri, Suzan Eren and Alireza Bakhshai",downloadPdfUrl:"/chapter/pdf-download/78818",previewPdfUrl:"/chapter/pdf-preview/78818",authors:[{id:"344010",title:"M.Sc.",name:"Hadis",surname:"Hajebrahimi",slug:"hadis-hajebrahimi",fullName:"Hadis Hajebrahimi"}],corrections:null},{id:"77485",title:"Power Quality in Renewable Energy Microgrids Applications with Energy Storage Technologies: Issues, Challenges and Mitigations",doi:"10.5772/intechopen.98440",slug:"power-quality-in-renewable-energy-microgrids-applications-with-energy-storage-technologies-issues-ch",totalDownloads:282,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Nowadays, the electric power distribution system is undergoing a transformation. The new face of the electrical grid of the future is composed of digital technologies, renewable sources and intelligent grids of distributed generation. As we move towards the electrical grid of the future, microgrids and distributed generation systems become more important, since they are able to unify small-scale and flexible generation to clean energy and intelligent controls. The microgrids play an important role in marking electrical grids more robust in the face of disturbances, increasing their resilience. Although the microgrid concept continues in discussion in technical circles, it can be defined as an aggregation of electrical elements in low generation voltage, storage and loads (users) which are grouped in a certain bounded geographical area. The issues of a microgrid integrated with energy storage technologies has gained increasing interest and popularity worldwide as these technologies provide the reliability and availability that are required for proper operation in the system. Actual studies show that the implementation of energy storage technologies in a microgrid improves transients, capacity, increases instantaneous power and allows the introduction of renewable energy systems. However, there are still certain unsolved problems in power quality terms. This article clearly describes those problems generated by each storage technology foe microgrids applications. All the ideas in this review contribute significantly to the growing effort towards developing a cost-effective and efficient energy storage technology model with a long-life cycle for sustainable implementation in microgrids.",signatures:"Emmanuel Hernández Mayoral, Efraín Dueñas Reyes, Reynaldo Iracheta Cortez, Carlos J. Martínez Hernández, Carlos D. Aguilar Gómez, Christian R. Jiménez Román, Juan D. Rodríguez Romero, Omar Rodríguez Rivera, Edwin F. Mendoza Santos, Wilder Durante Gómez and José I. Barreto Muñoz",downloadPdfUrl:"/chapter/pdf-download/77485",previewPdfUrl:"/chapter/pdf-preview/77485",authors:[{id:"344716",title:"Dr.",name:"Emmanuel",surname:"Hernandez Mayoral",slug:"emmanuel-hernandez-mayoral",fullName:"Emmanuel Hernandez Mayoral"},{id:"352041",title:"Mr.",name:"Carlos",surname:"D. Aguilar Gómez",slug:"carlos-d.-aguilar-gomez",fullName:"Carlos D. 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Barreto Muñoz"},{id:"420475",title:"Dr.",name:"Carlos J.",surname:"Martínez Hernández",slug:"carlos-j.-martinez-hernandez",fullName:"Carlos J. Martínez Hernández"},{id:"422336",title:"Dr.",name:"Juan D.",surname:"Rodriguez Romero",slug:"juan-d.-rodriguez-romero",fullName:"Juan D. Rodriguez Romero"}],corrections:null},{id:"79375",title:"An Overview Study of Micro-Grids for Self-Production in Renewable Energies",doi:"10.5772/intechopen.98829",slug:"an-overview-study-of-micro-grids-for-self-production-in-renewable-energies",totalDownloads:69,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Micro-grids (μ-grids) are small-scale power grids, specially designed to provide low voltage (LV) power supply to a small number of consumers. These networks include: different production units (energy resources), storage devices and local controllable loads, which have the possibility of being controlled. In this chapter, we will study in detail the constitution of an electrical micro-grid, their two operating modes (connected mode and islanded mode), and their controls. On the other hand, we will also discuss on hybrid micro-grids and their advantages. We will also discuss for the monitoring and data logging products used in micro-grids and hybrid micro-grids. Finally, at the end of this chapter we will ended with the importance of micro-grids systems.",signatures:"Hocine Sekhane",downloadPdfUrl:"/chapter/pdf-download/79375",previewPdfUrl:"/chapter/pdf-preview/79375",authors:[{id:"345906",title:"Dr.",name:"Sekhane",surname:"Hocine",slug:"sekhane-hocine",fullName:"Sekhane Hocine"}],corrections:null},{id:"76141",title:"Salp Swarm Optimization with Self-Adaptive Mechanism for Optimal Droop Control Design",doi:"10.5772/intechopen.97229",slug:"salp-swarm-optimization-with-self-adaptive-mechanism-for-optimal-droop-control-design",totalDownloads:63,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The collaboration of the various distributed generation (DG) units is required to meet the increasing electricity demand. To run parallel-connected inverters for microgrid load sharing, several control strategies have been developed. Among these methods, the droop control method was widely accepted in the research community due to the lack of important communication links between parallel-connected inverters to control the DG units within a microgrid. To help to solve the power-sharing process, keep to frequency and voltage constrained limits in islanded mode microgrid system. The parameter values must therefore be chosen accurately by using the optimization technique. Optimization techniques are a hot topic of researchers; hence This paper discusses the microgrid droop controller during islanding using the salp swarm inspired algorithm (SSIA). To obtain a better fine microgrid output reaction during islanding, SSIA-based droop control is used to optimally determine the PI gain and the coefficients of the prolapse control. The results of the simulation show that the SSIA-based droop control can control the power quality of the microgrid by ensuring that the keep to frequency and voltage constrained limits and deviation and proper power-sharing occurs during the microgrid island mode during a load change.",signatures:"Mohamed A. Ebrahim, Reham M. Abdel Fattah, Ebtisam M. Saied, Samir M. Abdel Maksoud and Hisham El Khashab",downloadPdfUrl:"/chapter/pdf-download/76141",previewPdfUrl:"/chapter/pdf-preview/76141",authors:[{id:"344676",title:"Dr.",name:"Mohamed A.",surname:"Ebrahim",slug:"mohamed-a.-ebrahim",fullName:"Mohamed A. Ebrahim"},{id:"344677",title:"Prof.",name:"Ebtisam M.",surname:"Saied",slug:"ebtisam-m.-saied",fullName:"Ebtisam M. Saied"},{id:"344678",title:"Dr.",name:"Samir M.",surname:"Abdel Maksoud",slug:"samir-m.-abdel-maksoud",fullName:"Samir M. Abdel Maksoud"},{id:"344679",title:"Dr.",name:"Reham M.",surname:"Abdel Fattah",slug:"reham-m.-abdel-fattah",fullName:"Reham M. 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Hidden losses in the technological system occur accidentally due to the appearance of defects in the equipment, erroneous actions of personnel, changes in uncontrolled external conditions. The paper considers a method of detecting and estimating hidden energy losses, based on the analysis of energy consumption precedents and building a decision support system aimed at eliminating such energy losses. Models of energy consumption precedents are formed on the basis of controlled technological parameters and their statistical estimates. In the future, local standards of efficient energy consumption are formed from individual precedents. The advantage of this method of estimating latent energy losses is the adaptation of standards of efficient energy consumption to the conditions of the consumer.",signatures:"Borys Pleskach",downloadPdfUrl:"/chapter/pdf-download/76470",previewPdfUrl:"/chapter/pdf-preview/76470",authors:[{id:"345292",title:"Ph.D.",name:"Borys",surname:"Pleskach",slug:"borys-pleskach",fullName:"Borys Pleskach"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2023",title:"Sustainable Growth and Applications in Renewable Energy Sources",subtitle:null,isOpenForSubmission:!1,hash:"a32b4ca624cca7957ede00fcc24b834a",slug:"sustainable-growth-and-applications-in-renewable-energy-sources",bookSignature:"Majid Nayeripour and Mostafa Kheshti",coverURL:"https://cdn.intechopen.com/books/images_new/2023.jpg",editedByType:"Edited 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\r\n\tSince 2500 BC, a wealth of knowledge and experience has been accumulated in the practice of acupuncture and moxibustion. Since then, acupuncture and moxibustion have been used throughout the world, particularly since the 1970s. According to the theory of traditional Chinese medicine, acupuncture evolved following the principle that physiological functions are maintained through the “meridian” and “Qi and blood” systems. Along 14 meridians, 365 identified acupoints can relieve Qi stagnation for stimulating, balancing, and harmonizing the yin and yang. This treatment has been used to facilitate the homeostasis of human organs. Due to the development of biotechnology, it is easier to elucidate the mechanism of action for acupuncture and moxibustion. As for acupuncture and moxibustion research methodology, there is no doubt that a double-blind, randomized, placebo-controlled trial is the gold standard, but in regard to clinical practice, most practitioners and patients primarily focus on therapeutic outcomes. For clinical practice, one should bear in mind that the outcome of acupuncture and moxibustion is closely related to acupoint specification, needling techniques, number and duration of treatment sessions, manipulation methods, and even needles and physical state of the patient. Therefore, to achieve the best effects, emphasis should be placed on optimizing and standardizing acupuncture parameters and procedures.
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\r\n\tThis book intends to provide the reader with a comprehensive overview of the recent advances, new perspectives, and applications of acupuncture and moxibustion that focuses on the most important evidence-based developments in this critically important area.
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1. Introduction
Ginseng is a slow-growing, deciduous, perennial plant of the Araliaceae family which includes Panax ginseng (Renshen, Chinese or Korean ginseng), Panax japonicus (Japanese ginseng) and Panax quinquefolius (Xiyangshen, American ginseng) among others [1]. Ginseng contains an extraordinarily complex mixture of chemical constituents that can vary with the species used, the place of origin, and the growing conditions [2]. Ginsengs has found therapeutic application such as anti-inflammatory, anti-haemostatic, antioxidant, anticancer, anti-diabetic, antiaging, anti-depressive, immunomodulatory, analgesic, neuroprotection, memory and learning enhancement effects in animals and humans [1, 3, 4, 5, 6, 7]. Various computational analyses which include genomics, transcriptomics, proteomics and bioinformatics have been used to study ginseng plant [4, 8, 9, 10].
1.1 Ginseng genomics and biosynthesis of ginsenosides
A genome-scale metabolic network offers a holistic view of ginsenoside biosynthesis, helps to predict genes associated with the production of pharmacologically vital dammarane-type ginsenosides, and provides insight for improving medicinal values of ginseng by genomics-based breeding [11]. The draft genomic architecture of tetraploid P. ginseng cultivar (cv.) Chunpoong, by de novo genome assembly, was reported to be 2.98 Gbp and consist of 59,352 annotated genes [11]. Recently, a dynamic database was built that integrates a draft genome sequence, transcriptome profiles, and annotation datasets of ginseng, which is publicly available (http://ginsengdb.snu.ac.kr/) for the use of scientific community around the globe for exploring the valuable resources for a range of research fields related to P. ginseng and few other species [4]. Transcriptome analysis has identified 100 Panax ginseng cytochrome P450 (PgCYP) genes, whose expressions were significantly correlated with variation of nine mono- and total-ginsenoside contents, while further association study identified five SNPs and three InDels from six PgCYP genes that were significantly associated with the ginsenoside contents in the four-year-old roots of 42 genotypes [9].
2. Ginsenosides: structure, pharmacokinetics and mechanism
Ginsenosides are specific types of triterpene saponin, a broad group of chemical compounds. Ginsenosides are found nearly exclusively in Panax species (ginseng) and up to now more than 150 naturally occurring ginsenosides have been isolated from different organs of ginseng [12]. Ginsenosides appear to be responsible for most of the activities of ginseng including anti-diabetic, anti-allergic, anticarcinogenic, anti-inflammatory, anti-atherosclerotic, antihypertensive, and immunomodulatory effects as well as anti-stress activity and effects on the central nervous system [6]. The structures of ginsenosides Rb1 and Rg1 are shown in Figure 1.
Figure 1.
Structures of ginsenosides Rb1 and Rg1. (Adapted from [5]).
2.1 Structure of ginsenosides
Shi et al. [13] have reported that the seven major ginsenosides (Rg1, Re, Rb1, Rc, Rb2, Rb3 and Rd) were present in various parts of Chinese ginseng of various ages. Ginsenoside content is higher in the leaf and root hair but lower in the stem than that in other parts of the plant and that the total content of ginsenosides in the leaf decreases with age [1, 13]. Ginsenosides are divided into three main categories, the 20(S)-protopanaxadiol, 20(S)-proto- panaxatriol and oleanane families according to the number and position of sugar moieties on the sterol chemical structure. it is difficult to clarify the influence of the sugar moiety at different positions on pharmacological actions [14].
2.2 ADME of ginsenosides
Absorption, distribution, metabolism and excretion (ADME) describe the pharmacokinetics and pharmacodynamics of a single or more compounds in an organism such as human, mouse etc. The knowledge of pharmacokinetics of ginsenoside and its metabolites is very imperative in designing an optimal dosage regimen and minimizing the adverse effect that may result from ginseng-drugs interaction. The polar ginsenosides include Rg1, Re, Rb1, Rc, Rb2, Rb3, and Rd., while less polar ginsenosides include Rg2, Rg3, Rg5, Rh2, Rk1, and Rs4 [15, 16]. Protopanaxadiol ginsenosides are metabolized to ginsenoside compound K by the intestinal microflora in humans. Ginsenoside compound K (20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol), is found in the blood stream of humans as an active metabolite after oral administration of protopanaxadiol ginsenosides Rb1, Rb2, Rc, and Rd., and has significantly higher mean maximum plasma concentration and significantly lower half-life when compare to the ginsenoside Rb1 [17].
According to Qi et al., [18], the ginseng saponins have low absorption rate and characterized by extensive metabolism in the gastrointestinal tract, poor membrane permeability, and low solubility of deglycosylated products; and with less than 5% dose bioavailability of the protopanaxadiol (PPD) group of saponins (ginsenosides Ra3, Rb1, Rd., Rg3, and Rh2) and of the protopanaxatriol (PPT) group of saponins (ginsenosides Rg1, Re, Rh1, and R1) were less than 5%. However, PPT saponins have better bioavailability than PPD saponins, which may be due to the fact that PPD saponins degrade faster than PPT saponins. Study on ginseng absorption by HPLC analysis, showed that Rb1 (4.35%) and Rg1 (18.40%) were absorbed, respectively [19].
Study on the effect of American ginseng and Asian ginseng extracts on gene expression of the hepatic cytochrome P450 enzyme in elderly humans, has shown that protopanaxadiol (PPD), protopanaxatriol (PPT) and their metabolites, moderately inhibited CYP2C9 activity and strongly inhibited CYP3A4 activity [20, 21]. Henderson et al., [22] have studied the effects of seven naturally occurring ginsenosides Rb1, Rb2, Rc, Rd., Re, Rf, and Rg1 and eleutherosides B and E (active components of the ginseng root) on the catalytic activity of cDNA expressed CYPs (CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4) in in vitro experiments. They found that the ginsenosides and eleutherosides tested are not likely to inhibit the metabolism of co-administered medications in which the primary route of elimination is via cytochrome P450 [22]. Comprehensive review of the ginseng active compounds pharmacokinetics, drug–drug interaction, and influence of cytochrome P450 has been published [23]. Chemical constituents of P. ginseng and mechanisms of selected ginseng compounds are shown in Tables 1 and 2 respectively.
Downregulation of nuclear factor-kappa B (NF-𝜅B)/nitric oxide (NO) signaling pathway, increases the expression of insulin growth factor I receptor (IGF-IR)
Phosphoinositide-3-kinase/AKT and phosphoextracellular signal-regulated protein kinase (ERK) 1/2 pathways, suppress poly(ADP-ribose) polymerase-1, protein tyrosine kinase activation, the upregulation of the endogenous antioxidant system and GAP-43 expression
Modulation of three modules of MAP kinases, P-gp (P-glycoprotein) inhibition, modulation of Ephrin receptor pathway, inhibits NMDA receptor by increasing the concentration of glycine, suppression of TPA-induced cyclooxygenase-2 (COX-2) expression
The molecular mechanism of ginsenosides pharmacological activities.
3. Bioinformatics analyses of ginsenosides
A study has proposed a novel method to explore underlying mechanisms of multiple actions of multiple constituents of Ginseng (Panax ginseng) against cancers, and the bioinformatics analyses was initiated with proteins regulated by ginsenoside rb1/re/rg1, using standard tools such as ChEMBL, STRING, DAVID and KEGG [43].
In the study conducted by Yan et al. [44] to identify immunomodulatory biomarkers in an immune cell induced by ginseng, microarray assays were carried out to identify differentially expressed genes associated with American ginseng (Panax quinquefolius) exposure to 4 groups of Murine splenic cells from adult male C57BL/6 (B6) mice which were isolated to mimic 4 basic pathophysiological states. The microarray data obtained was analyzed with Partek Genomics Suite software while DAVID Bioinformatics Resources 6.7 was used for functional annotation clustering. The effect of American ginseng on the interferon gamma signaling functions was obtained by the use of Interferome software [44].
In their study, Zhu et al. [8], have reported two major Panax ginseng glycoprotein (PGG-1 and PGG-2) obtained by high performance liquid chromatography, with the molecular weights of 1.5 KDa and 8.2 KDa respectively calculated by gel permeation chromatography. The ginseng samples were analyzed by LC–MS using a nanoflow RP-HPLC online-coupled to a Q Exactive mass spectrophotometer operating in the positive ion mode. The raw MS files were analyzed and searched against the UniProt ginseng protein sequence database using Byonic software (Version 2.3.5). The computed parameters of PGG determined by MS include theoretical isoelectric point (pI), instability index, aliphatic index and grand average of hydropathicity (GRAVY). The aliphatic index of PGG-1 ranged from 0 to 130, with an average of 48.23; the aliphatic index of PGG-2 ranged from 61.25 to 195.71, with an average of 129.41 [8].
Bioinformatics network analysis has been used to analyzed a combination of ginseng and arginine regimen, ginseng and lingzhi as well as ginseng and gingko regimens [45, 46], in order to understand potential impact of drug–drug interaction (agonism or antagonism) based on common pathways.
3.1 In silico target prediction and gene expression network of key ginseng constituents
The ligands (Ginsenoside Rb1, Rc, Rg3, Re, F1, C; Betasitosterol, Panaxadione, Daucosterin (also known as Sitogluside or Eleutheroside A), and 20(R)-protopanaxatriol) were subjected to in silico target prediction on SwissTargetPrediction server where Homo sapiens was selected as target organism [47] as shown in Table 3. Forty-five (45) genes (PTAFR, IL2, STAT3, VEGFA, FGF1, FGF2, HPSE, PSEN1, PSENEN, NCSTN, BCL2L1, PRKCA, HSD11B1, CYP19A1, SIRT2, PTPN1, CCR1, VDR, PTPN11, NR1I2, REN, BACE1, NR3C1, INSR, ITK, F2R, AR, HMGCR, CYP51A1, NPC1L1, NR1H3, CYP19A1, CYP17A1, RORC, ESR1, ESR2, CYP2C19, CHRM2, SLC6A2, SLC6A4, ACHE, HSD11B1, ATP12A, HMGCR, CYP51A1) were extracted from the predicted targets and subjected to expression network analyses (transcription factor enrichment analysis, protein–protein interaction network expansion and kinase enrichment analysis), using eXpression2Kinases (X2K) Web server [48] as shown Figures 2–5.
The genes that were targeted by Betasitosterol (Table 3) have greater than 30% probability (35–70%), Daucosterin targeted Interleukin-2 (IL2) with 60% probability, while others were less than 30%. The best target of Betasitosterol is Androgen Receptor (AR), followed by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, Cytochrome P450 51, Niemann-Pick C1-like protein 1, LXR-alpha, Cytochrome P450 19A1, Cytochrome P450 17A1, Nuclear receptor ROR-gamma and others.
This study shows that SUZ12 has the highest score as transcription factor influenced by the ginseng, this is followed by STAT3, RUNX1, FOS, VDR, RCOR1, SPI1 and EGR1 (Figures 2 and 3). The kinases that were impacted by the action of ginseng active constituents include MAPK1, MAPK14, AKT1, CDK1, ABL1, ERK1 and ERK2 (Figure 4). Moreover, major intermediate proteins JUN, RARA, NCOR1, MYC, RB1, HDAC2, CSNK2A1 and others (Figure 5).
Zhang et al. [49] have reported ginsenoside, stigmasterol, β-sterol, β-elemene and β-selinene, kaempferol, panaxynol, ginsenoyne A, fumarine, girinimbin, elemicin, dauricine, and maltol, as part of secondary metabolites produced by ginseng. However, network analysis of ginseng-associated targets ginseng in treatment of depression which could occur in post-COVID19 period, identified AKT1, CASP3, NOS3, TNF, and PPARG as the core genes in protein–protein interaction network, and that ginsenoside Re, ginsenoside Rg1, frutinone A and kaempferol were the key ingredients in ginseng for immune-regulation [50].
Based on curated data on UniProt database (www.uniprot.org), androgen receptor (Uniprot ID: P10275) involves in positive regulation of MAPK cascade, NF-kappaB transcription factor activity, insulin-like growth factor receptor signaling pathway, and transcription by RNA polymerase II and III, as well as negative regulation of transcription by RNA polymerase II, epithelial cell proliferation, and extrinsic apoptotic signaling pathway. HMG-CoA reductase (UniProt ID: P04035) involves in positive regulation of ERK1 and ERK2 cascade, stress-activated MAPK cascade, cardiac muscle cell apoptotic process, smooth muscle cell proliferation, and cholesterol homeostasis, as well as negative regulation of MAP kinase activity, wound healing, and striated muscle cell apoptotic process, and it also give response to ethanol. Interleukin-2 (UniProt ID: P60568) involves in positive regulation of inflammatory response, transcription by RNA polymerase II, tyrosine phosphorylation of STAT protein, interferon-gamma production, B cell and activated T cell proliferation and immunoglobulin secretion, as well as negative regulation of inflammatory response, heart contraction, B cell apoptotic process, and lymphocyte proliferation, and it also give response to ethanol.
A comprehensive review of betasitosterol has reported several therapeutic potentials which include antioxidant, antipyretic, anti-inflammatory, anti-arthritic, and antimicrobial activities, as well as anti-cancer, anti-diabetic, antihyperlipidemic, anti-atherosclerosis, anti-pulmonary tuberculosis, angiogenic, immune modulation and anti-HIV effects [51].
4. Conclusion
Knowledge of bioinformatics has not been fully applied to the study of ginseng in proportionality to the acclaimed medicinal properties from the ethnobotanical use.
This study has applauded Betasitosterol and Daucosterin as ginseng bioactive constituents that have several potential pharmacological effects in human, by modulating several proteins which include androgen receptor, HMG-CoA reductase, interlukin-2, and consequently impact the signaling cascade of several kinases such as Mitogen-activated protein kinases (MAPKs), as well as many transcription factors such as Polycomb protein SUZ12. Moreover, difference in pharmacological outcome of aqueous ginseng extract and ethanolic ginseng extract would necessitate holistic approach of extraction. Furthermore, chemical biology and in silico simulation of pharmacological potential of ginseng bioactive compounds (such as molecular docking and dynamics, drug–drug interaction) will yield significant insights to the presently unexplored molecular mechanisms of action to explain the therapeutic effect of ginseng.
Acknowledgments
This research has no acknowledgment.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"Ginseng, bioinformatics, transcriptomics, genomics, bioactive, pharmacokinetics",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/75231.pdf",chapterXML:"https://mts.intechopen.com/source/xml/75231.xml",downloadPdfUrl:"/chapter/pdf-download/75231",previewPdfUrl:"/chapter/pdf-preview/75231",totalDownloads:185,totalViews:0,totalCrossrefCites:1,dateSubmitted:"December 17th 2020",dateReviewed:"January 23rd 2021",datePrePublished:"May 4th 2021",datePublished:"June 15th 2022",dateFinished:"February 12th 2021",readingETA:"0",abstract:"Ginseng contains an extraordinarily complex mixture of chemical constituents that can vary with the species used, the place of origin, and the growing conditions. Various computational analyses which include genomics, transcriptomics, proteomics and bioinformatics have been used to study ginseng plant. A genome-scale metabolic network offers a holistic view of ginsenoside biosynthesis, helps to predict genes associated with the production of pharmacologically vital dammarane-type ginsenosides, and provides insight for improving medicinal values of ginseng by genomics-based breeding. The draft genomic architecture of tetraploid P. ginseng cultivar (cv.) Chunpoong (ChP) by de novo genome assembly, was found to be 2.98 Gbp and consist of 59,352 annotated genes. Presently, bioinformatics exploration of ginseng includes studies on its P-glycoproteins, the impact of cytochrome P-450 on ginseng pharmacokinetics, as well as target prediction and differential gene expression network analyses. This study applauded Betasitosterol and Daucosterin as ginseng bioactive constituents that have several potential pharmacological effects in human, by modulating several proteins which include androgen receptor, HMG-CoA reductase, interlukin-2, and consequently impact the signaling cascade of several kinases such as mitogen-activated protein kinases (MAPKs), as well as many transcription factors such as polycomb protein SUZ12.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/75231",risUrl:"/chapter/ris/75231",signatures:"Toluwase Hezekiah Fatoki",book:{id:"10539",type:"book",title:"Ginseng",subtitle:"Modern Aspects of the Famed Traditional Medicine",fullTitle:"Ginseng - Modern Aspects of the Famed Traditional Medicine",slug:"ginseng-modern-aspects-of-the-famed-traditional-medicine",publishedDate:"June 15th 2022",bookSignature:"Christophe Hano and Jen-Tsung Chen",coverURL:"https://cdn.intechopen.com/books/images_new/10539.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-057-0",printIsbn:"978-1-83969-056-3",pdfIsbn:"978-1-83969-058-7",isAvailableForWebshopOrdering:!0,editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"338172",title:"M.Sc.",name:"Toluwase",middleName:null,surname:"Hezekiah Fatoki",fullName:"Toluwase Hezekiah Fatoki",slug:"toluwase-hezekiah-fatoki",email:"hezekiahfatoki@gmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Ginseng genomics and biosynthesis of ginsenosides",level:"2"},{id:"sec_3",title:"2. Ginsenosides: structure, pharmacokinetics and mechanism",level:"1"},{id:"sec_3_2",title:"2.1 Structure of ginsenosides",level:"2"},{id:"sec_4_2",title:"2.2 ADME of ginsenosides",level:"2"},{id:"sec_6",title:"3. Bioinformatics analyses of ginsenosides",level:"1"},{id:"sec_6_2",title:"3.1 In silico target prediction and gene expression network of key ginseng constituents",level:"2"},{id:"sec_8",title:"4. Conclusion",level:"1"},{id:"sec_9",title:"Acknowledgments",level:"1"},{id:"sec_12",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Wang H., Peng D., and Xie J., Ginseng leaf-stem: bioactive constituents and pharmacological functions. Chinese Medicine 2009, 4:20. DOI: 10.1186/1749-8546-4-20'},{id:"B2",body:'Lee SY, Kim YK, Park N-II, Kim CS, Lee CY, and Park SU. 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DOI: 10.1021/cr100174k.'},{id:"B15",body:'Lau AJ, Seo BH, Woo SO, Koh HL. High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng. J Chromatogr A. 2004,1057:141-149. DOI: 10.1016/j.chroma.2004.09.069'},{id:"B16",body:'Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A. 2001;921:335-339. DOI: 10.1016/s0021-9673(01)00869-x'},{id:"B17",body:'Kim H-K, Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract. J Ginseng Res 2013; 37(4): 451-456. DOI: 10.5142/jgr.2013.37.451'},{id:"B18",body:'Qi LW, Wang CZ, Du GJ, Zhang ZY, Calway T, Yuan CS. Metabolism of ginseng and its interactions with drugs. Curr Drug Metab. 2011;12(9):818-822. DOI: 10.2174/138920011797470128.'},{id:"B19",body:'Xu QF, Fang XL, Chen DF. Pharmacokinetics and bioavailability of ginsenoside Rb1 and Rg1 from Panax notoginseng in rats. Journal of Ethnopharmacol. 2003; 84: 187-192. DOI: 10.1016/s0378-8741(02)00317-3'},{id:"B20",body:'Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Cui YY, Ang CYW. Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly - St John\'s wort, garlic oil, Panax ginseng and Ginkgo biloba. Drug Aging. 2005; 22(6):525-539. DOI: 10.2165/00002512-200522060-00006'},{id:"B21",body:'Liu Y, Zhang JW, Li W, Ma H, Sun J, Deng MC, Yang L. Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes. Toxicol. Sci. 2006; 91(2):356-364. DOI: 10.1093/toxsci/kfj164'},{id:"B22",body:'Henderson GL, Harkey MR, Gershwin ME, Hackman RM, Stern JS, Stresser DM. Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. Life Sci 1999; 65(15):PL209–PL214. DOI: 10.1016/s0024-3205(99)00407-5'},{id:"B23",body:'Yang L., Liu Y., and Liu C-X., Metabolism and pharmacokinetics of ginsenosides. Asian Journal of Pharmacodynamics and Pharmacokinetics 2006; 6(2):103-120.'},{id:"B24",body:'Wang JY, Li XG, Yang XW. Ginsenine, a new alkaloid from the berry of Panax ginseng C. A. Meyer. J. Asian Nat. Prod. Res. 2006;8: 605-608. DOI: 10.1080/10286020500208444'},{id:"B25",body:'Zhao YQ, Yuan CL. Chemical constituents of the fruit of Panax ginseng C. A. Meyer. Zhongguo Zhong Yao Za Zhi. 1993;18: 296-297.'},{id:"B26",body:'Wang JY, Li XG, Zheng YN, Yang XW. Isoginsenoside-Rh3, a new triterpenoid saponin from the fruits of Panax ginseng C. A. Mey. J. Asian Nat. Prod. Res. 2004;6: 289-293. DOI: 10.1080/10286020310001595980'},{id:"B27",body:'Wang W, Zhao Y, Rayburn E, Hill D, Wang H, Zhang R. In vitro anti-cancer activity and structure–activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother. Pharmacol. 2007;59: 589-601. DOI: 10.1007/s00280-006-0300-z'},{id:"B28",body:'Sugimoto S, Nakamura S, Matsuda H, Kitagawa N, Yoshikawa M. Chemical Constituents from Seeds of Panax ginseng: Structure of New Dammarane-Type Triterpene Ketone, Panaxadione, and HPLC Comparisons of Seeds and Flesh. Chem. Pharm. Bull. 2009;57: 283-287. DOI: 10.1248/cpb.57.283'},{id:"B29",body:'Attele A.S., Wu J.A., and Yuan C.S. Ginseng pharmacology: multiple constituents and multiple actions. Biochemical Pharmacology. 1999;581(11),1685-1693. DOI: 10.1016/s0006-2952(99)00212-9'},{id:"B30",body:'Shang W, Yang Y, Zhou L, Jiang B, Jin H, Chen M. Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes. J Endocrinol 2008; 198:561-569. DOI: 10.1677/JOE-08-0104'},{id:"B31",body:'Park S, Ahn IS, Kwon DY, Ko BS, Jun WK. Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. Biosci Biotechnol Biochem 2008; 72:2815-2823. DOI: 10.1271/bbb.80205'},{id:"B32",body:'Liu, D.; Zhang, H.; Gu, W.; Liu, Y.; Zhang, M. Ginsenoside Rb1 Protects Hippocampal Neurons from High Glucose-induced Neurotoxicity by Inhibiting GSK3β-mediated CHOP Induction. Mol. Med. Rep. 2014, 9, 1434-1438. DOI: 10.3892/mmr.2014.1958'},{id:"B33",body:'Fujimoto J, Sakaguchi H, Aoki I, Toyoki H, Khatun S & Tamaya T. Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane. Eur J. Gynaecol. Oncol. 2001;22:339-341.'},{id:"B34",body:'Wu J, Yang H, Zhao Q, Zhang X, Lou Y. Ginsenoside Rg1 exerts a protective effect against Aβ₂₅₋₃₅-induced toxicity in primary cultured rat cortical neurons through the NF-κB/NO pathway. Int J Mol Med. 2016;37(3):781-788. DOI: 10.3892/ijmm.2016.2485.'},{id:"B35",body:'Chen WF, Lau WS, Cheung PY, Guo DA, Wong MS. Activation of insulin-like growth factor I receptor-mediated pathway by ginsenoside Rg1. Br J Pharmacol. 2006 Mar;147(5):542-551. DOI: 10.1038/sj.bjp.0706640.'},{id:"B36",body:'Zhang X, Shi M, Bjørås M, Wang W, Zhang G, Han J, Liu Z, Zhang Y, Wang B, Chen J, Zhu Y, Xiong L, Zhao G. Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways. Front Pharmacol. 2013;4:152. DOI: 10.3389/fphar.2013.00152.'},{id:"B37",body:'Hu G, Wu Z, Yang F, Zhao H, Liu X, Deng Y, Shi M, Zhao G. Ginsenoside Rd blocks AIF mitochondrio-nuclear translocation and NF-κB nuclear accumulation by inhibiting poly(ADP-ribose) polymerase-1 after focal cerebral ischemia in rats. Neurol Sci. 2013;34(12):2101-2106. DOI: 10.1007/s10072-013-1344-6.'},{id:"B38",body:'Chen L.M., Zhou X.M., Cao Y.L., and Hu W.X. Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats. Journal of Asian Natural Products Research. 2008:10(5), 439-445. DOI: 10.1080/10286020801892292'},{id:"B39",body:'Kim SW, Kwon HY, Chi DW, Shim JH, Park JD, Lee YH, Pyo S., Rhee DK. Reversal of P- glycoprotein-mediated multidrug resistance by ginsenoside Rg3. Biochem. Pharmacol. 2003;65(1): 75-82. DOI: 10.1016/s0006-2952(02)01446-6'},{id:"B40",body:'Kim HS, Lee EH, Ko SR, Choi KJ, Park JH., Im DS. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch. Pharm. Res. 2004; 27:429-435. DOI: 10.1007/BF02980085'},{id:"B41",body:'Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, et al. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol 2008; 32:975-983. DOI: 10.3892/ijo.32.5.975'},{id:"B42",body:'Surh YJ, Na HK, Lee JY, Keum YS. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. J Korean Med Sci 2001;16:38-41. DOI: 10.3346/jkms.2001.16.S.S38'},{id:"B43",body:'Zheng G., Wang J. Protein Regulating Networks underlying Multiple Actions against Cancer Delivered by Ginseng. 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 2018;1977-1981.'},{id:"B44",body:'Yan J, Ma Y., Zhao F., Gu W., Jiao Y. Identification of Immunomodulatory Signatures Induced by American Ginseng in Murine Immune Cells. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 972814, 1-12. DOI: 10.1155/2013/972814'},{id:"B45",body:'Joob B, Wiwanitkit V. Combination between ginseng and arginine regimen: Is there any synergistic effect? J Med Trop 2016;18:18-21. DOI: 10.4103/2276-7096.176048'},{id:"B46",body:'Ong Lai Teik D, Lee XS, Lim CJ, Low CM, Muslima M, Aquili L. Ginseng and Ginkgo biloba Effects on Cognition as Modulated by Cardiovascular Reactivity: A Randomised Trial. PLoS One. 2016;11(3):e0150447. DOI: 10.1371/journal.pone.0150447.'},{id:"B47",body:'Diana A, Michielin O, Zoete V. SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Research. 2019;1-8. DOI: 10.1093/nar/gkz382'},{id:"B48",body:'Clarke, D.J.B.; Kuleshov, M.V.; Schilder, B.M.; Torre, D.; Duffy, M.E.; Keenan, A.B.; Lachmann, A.; Feldmann A.S.; Gundersen G.W.; Silverstein M.C.; Wang Z.; Ma’ayan A. eXpression2Kinases (X2K) Web: linking expression signatures to upstream cell signaling networks. Nucleic Acids Res. 2018, 46, W1: 171-179. DOI: 10.1093/nar/gky458'},{id:"B49",body:'Zhang H, Abid S, Ahn J.C, Mathiyalagan R, Kim Y-J, Yang D-C, and Wang Y, (2020). Characteristics of Panax ginseng Cultivars in Korea and China. Molecules 2020, 25, 2635; DOI: 10.3390/molecules25112635'},{id:"B50",body:'Wang N., Wang X., He M., Zheng W., et al. Network pharmacology-based active compounds and pharmacological mechanisms of ginseng for depression in post-COVID-19. Research Square, 2020;1-12. DOI: 10.21203/rs.3.rs-40858/v1'},{id:"B51",body:'Bin Sayeed MS, Karim SMR, Sharmin T, and Morshed MM. Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol. Medicines 2016, 3, 29; DOI: 10.3390/medicines3040029'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Toluwase Hezekiah Fatoki",address:"toluwase.fatoki@fuoye.edu.ng;, hezekiahfatoki@gmail.com",affiliation:'
Department of Biochemistry, Federal University Oye, Oye-Ekiti, Ekiti State, Nigeria
'}],corrections:null},book:{id:"10539",type:"book",title:"Ginseng",subtitle:"Modern Aspects of the Famed Traditional Medicine",fullTitle:"Ginseng - Modern Aspects of the Famed Traditional Medicine",slug:"ginseng-modern-aspects-of-the-famed-traditional-medicine",publishedDate:"June 15th 2022",bookSignature:"Christophe Hano and Jen-Tsung Chen",coverURL:"https://cdn.intechopen.com/books/images_new/10539.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-057-0",printIsbn:"978-1-83969-056-3",pdfIsbn:"978-1-83969-058-7",isAvailableForWebshopOrdering:!0,editors:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"194563",title:"Dr.",name:"Péter",middleName:null,surname:"Vass",email:"gfvassp@uni-miskolc.hu",fullName:"Péter Vass",slug:"peter-vass",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:null},booksEdited:[],chaptersAuthored:[{id:"53143",title:"Inversion-Based Fourier Transform as a New Tool for Noise Rejection",slug:"inversion-based-fourier-transform-as-a-new-tool-for-noise-rejection",abstract:"In this study, a new inversion method is presented for performing two-dimensional (2D) Fourier transform. The discretization of the continuous Fourier spectra is given by a series expansion with the scaled Hermite functions as square-integrable set of basis functions. The expansion coefficients are determined by solving an overdetermined inverse problem. In order to define a quick algorithm in calculating the Jacobian matrix of the problem, the special feature that the Hermite functions are eigenfunctions of the Fourier transformation is used. In the field of inverse problem theory, there are numerous procedures for noise rejection, so if the Fourier transformation is formulated as an inverse problem, these tools can be used to reduce the noise sensitivity. It was demonstrated in many case studies that the use of Cauchy-Steiner weights could increase the noise rejection capability of geophysical inversion methods. Following this idea, the two-dimensional Fourier transform is formulated as an iteratively reweighted least squares (IRLS) problem using Cauchy-Steiner weights. The new procedure is numerically tested using synthetic data.",signatures:"Mihály Dobróka, Hajnalka Szegedi and Péter Vass",authors:[{id:"189265",title:"Prof.",name:"Mihály",surname:"Dobróka",fullName:"Mihály Dobróka",slug:"mihaly-dobroka",email:"dobroka@uni-miskolc.hu"},{id:"194562",title:"MSc.",name:"Hajnalka",surname:"Szegedi",fullName:"Hajnalka Szegedi",slug:"hajnalka-szegedi",email:"gfszh@uni-miskolc.hu"},{id:"194563",title:"Dr.",name:"Péter",surname:"Vass",fullName:"Péter Vass",slug:"peter-vass",email:"gfvassp@uni-miskolc.hu"}],book:{id:"5411",title:"Fourier Transforms",slug:"fourier-transforms-high-tech-application-and-current-trends",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"20909",title:"Dr.",name:"Marco Q.",surname:"Pisani",slug:"marco-q.-pisani",fullName:"Marco Q. Pisani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Istituto Nazionale di Ricerca Metrologica",institutionURL:null,country:{name:"Italy"}}},{id:"23261",title:"Prof.",name:"Goran",surname:"Nikolic",slug:"goran-nikolic",fullName:"Goran Nikolic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/23261/images/system/23261.jpg",biography:"Dr. Goran Nikolić was born in Knez Selo (Niš, Serbia) on 1 November 1966. He received his B.Sc. degree in Chemistry (1990), M.Sc. degree in Organic Chemical Technology and Polymer Engineering (1996), and finally his PhD degree in Chemical Engineering (2002) from the University of Niš. Currently, he is a full professor at the same university, on Pharmaceutical-cosmetic engineering group of subjects at Faculty of Technology in Leskovac. His research activities are: quality control and stability of drugs, development of new pharmaceutical products (antianemic, antiseptic), pharmaceutical ingredients (synthesis and characterization), polynuclear and biocomplexes, surfactants. His competences are experience: in team work as a researcher, in project management, and managing of academic institution at different levels (vice dean, department chairman, head of chromatographic and spectrosopic laboratories, president of the quality assurance at the Faculty, and a member of the Committee for the improvement of the quality of the University). He is a member of the several national projects in the technological development area (granted by the Ministry of Science and Technological Development, Republic of Serbia), and member of numerous TEMPUS Joint European projects of sustainable technologies, environmental application and management courses (JPHES 2013, JPHES 2010, MCHEM 2010, IB-JEP 19020). He is a member of Serbian Chemical Society and Physicochemical Association of Serbia, and member of the Editorial Board of the journal Advanced Technologies. He has authored more than 300 scientific papers (in international and national scientific journals, on international conferences), numerous technological solutions for pharmaceutical industry, national monographies, international patents, university textbooks, invitation lecturers. He is the referee in numerous international and national journals, and editor of two international monographs on FTIR spectroscopy (InTech Open).",institutionString:"University of Niš",institution:{name:"University of Nis",institutionURL:null,country:{name:"Serbia"}}},{id:"189080",title:"Dr.",name:"Anca",surname:"Armăşelu",slug:"anca-armaselu",fullName:"Anca Armăşelu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Transylvania University of Brașov",institutionURL:null,country:{name:"Romania"}}},{id:"189265",title:"Prof.",name:"Mihály",surname:"Dobróka",slug:"mihaly-dobroka",fullName:"Mihály Dobróka",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Miskolc",institutionURL:null,country:{name:"Hungary"}}},{id:"194562",title:"MSc.",name:"Hajnalka",surname:"Szegedi",slug:"hajnalka-szegedi",fullName:"Hajnalka Szegedi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195519",title:"Dr.",name:"Milorad",surname:"Cakic",slug:"milorad-cakic",fullName:"Milorad Cakic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195519/images/5143_n.jpg",biography:"Prof. Milorad D. Cakić was born on 26 May 1951 in Leskovac, Serbia. He finished\b his studies at the Faculty of Chemistry in Skopje (Macedonia) in 1975. He completed his master studies in the field of molecular spectroscopy in 1978. His PhD thesis was defended at the same university in 1984. He was elected in 1985 as assistant professor at the University of Niš, Faculty of Technology in Leskovac, where he works today as a full professor. His main scientific interest is structure-spectral correlation investigations by different spectroscopic and chromatographic methods. He had published a number of articles in the field of synthesis and characterization of compounds with proven or potential pharmaceutical activity. He was an editor of many scientific publications and reviewer in a number of journals. His competences are experience in project management and managing of academic institution at different levels (dean, vice dean, head of the department, head of the laboratory, member of the senate, and deputy president of the Expert Board for Natural Sciences and Mathematics). Prof. Cakić is a member of the Board for the Accreditation of Scientific-Research Organizations of the Republic of Serbia.",institutionString:null,institution:null},{id:"195520",title:"MSc.",name:"Slobodan",surname:"Glišić",slug:"slobodan-glisic",fullName:"Slobodan Glišić",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195521",title:"Prof.",name:"Dragan",surname:"Cvetkovic",slug:"dragan-cvetkovic",fullName:"Dragan Cvetkovic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195521/images/5144_n.jpg",biography:"Prof. Dragan J. Cvetković was born on 26 June 1977 in Leskovac. He finished elementary and high school in Lebane, and then he completed his studies at the Faculty of Technology in Leskovac in the year 2002.He finished his PhD thesis in the year 2012 at the Faculty of Technology in Leskovac. Dragan Cvetković participated in the realization of numerous projects funded by the Ministry of Science, Republic of Serbia. He was engaged on the project “Folding and Stability of Phycobilisome Proteins” at the Institute of Biology and Technology of Saclay, France. He also participated in realization of the project entitled “Contribution of Chemical Quenching of Singlet Oxygen to Pro- and Antioxidant Activity of Carotenoids,” funded by the Polish Ministry of Science. He was elected as a teaching assistant in the year 2008on Physical Chemistry, Colloid Chemistry, and Instrumental Analysis, but in the year 2012, he was elected as an assistant professor on physicochemical group of subjects at the Faculty of Technology in Leskovac.",institutionString:null,institution:null},{id:"195522",title:"Dr.",name:"Žarko",surname:"Mitić",slug:"zarko-mitic",fullName:"Žarko Mitić",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195523",title:"MSc.",name:"Dragana",surname:"Marković-Nikolić",slug:"dragana-markovic-nikolic",fullName:"Dragana Marković-Nikolić",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195523/images/system/195523.png",biography:"Dr. Dragana Z. Marković-Nikolić was born on 28 December 1982 in Leskovac (Serbia). She completed her studies at the Faculty of Technology in Leskovac, University of Niš (2007). She recived her PhD degree in Applied Chemistry from the University of Niš (2018). She was elected as a teaching assistant at the High Technologically Artistic Professional School in Leskovac (2011), where she is still working. She is intensively engaged in scientific research in the field of ecological engineering. She published her research results in numerous scientific journals and presented at scientific meetings. She is the author of several technological solutions for industry, practical textbooks and book chapters. As an expert associate (2016), she acquired practical knowledge and skills for the application of contemporary instrumental and analytical methods, as well as skills for scientific research in the field of ecological engineering. She participated in the realization of TEMPUS project titled \\Creation of University-Enterprise Cooperation for Education on Sustainable Technologies\\. She is a member of the Chemical Society of Serbia.",institutionString:"University of Niš",institution:null}]},generic:{page:{slug:"OA-publishing-fees",title:"Open Access Publishing Fees",intro:"
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As a gold Open Access publisher, an Open Access Publishing Fee is payable on acceptance following peer review of the manuscript. In return, we provide high quality publishing services and exclusive benefits for all contributors. IntechOpen is the trusted publishing partner of over 140,000 international scientists and researchers.
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The Open Access Publishing Fee (OAPF) is payable only after your book chapter, monograph or journal article is accepted for publication.
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1,400 GBP Chapter - Edited Volume
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850 GBP Chapter - Book Series Topic (Annual Volume)
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10,000 GBP Monograph - Long Form
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During the launching phase journals do not charge an APC, rather they will be funded by IntechOpen.
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If a manuscript requires Heavy Editing or Language Polishing, this will incur additional fees.
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\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tIn general, the harsher the environmental conditions in an ecosystem, the lower the biodiversity. Changes in the environment caused by human activity accelerate the impoverishment of biodiversity.
\r\n
\r\n\tBiodiversity refers to “the variability of living organisms from any source, including terrestrial, marine and other aquatic ecosystems and the ecological complexes of which they are part; it includes diversity within each species, between species, and that of ecosystems”.
\r\n
\r\n\tBiodiversity provides food security and constitutes a gene pool for biotechnology, especially in the field of agriculture and medicine, and promotes the development of ecotourism.
\r\n
\r\n\tCurrently, biologists admit that we are witnessing the first phases of the seventh mass extinction caused by human intervention. It is estimated that the current rate of extinction is between a hundred and a thousand times faster than it was when man first appeared. The disappearance of species is caused not only by an accelerated rate of extinction, but also by a decrease in the rate of emergence of new species as human activities degrade the natural environment. The conservation of biological diversity is "a common concern of humanity" and an integral part of the development process. Its objectives are “the conservation of biological diversity, the sustainable use of its components, and the fair and equitable sharing of the benefits resulting from the use of genetic resources”.
\r\n
\r\n\tThe following are the main causes of biodiversity loss:
\r\n
\r\n\t• The destruction of natural habitats to expand urban and agricultural areas and to obtain timber, minerals and other natural resources.
\r\n
\r\n\t• The introduction of alien species into a habitat, whether intentionally or unintentionally which has an impact on the fauna and flora of the area, and as a result, they are reduced or become extinct.
\r\n
\r\n\t• Pollution from industrial and agricultural products, which devastate the fauna and flora, especially those in fresh water.
\r\n
\r\n\t• Global warming, which is seen as a threat to biological diversity, and will become increasingly important in the future.
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\r\n\tThe environment is subject to severe anthropic effects. Among them are those associated with pollution, resource extraction and overexploitation, loss of biodiversity, soil degradation, disorderly land occupation and planning, and many others. These anthropic effects could potentially be caused by any inadequate management of the environment. However, ecosystems have a resilience that makes them react to disturbances which mitigate the negative effects. It is critical to understand how ecosystems, natural and anthropized, including urban environments, respond to actions that have a negative influence and how they are managed. It is also important to establish when the limits marked by the resilience and the breaking point are achieved and when no return is possible. The main focus for the chapters is to cover the subjects such as understanding how the environment resilience works, the mechanisms involved, and how to manage them in order to improve our interactions with the environment and promote the use of adequate management practices such as those outlined in the United Nations’ Sustainable Development Goals.
\r\n\tPollution is caused by a wide variety of human activities and occurs in diverse forms, for example biological, chemical, et cetera. In recent years, significant efforts have been made to ensure that the environment is clean, that rigorous rules are implemented, and old laws are updated to reduce the risks towards humans and ecosystems. However, rapid industrialization and the need for more cultivable sources or habitable lands, for an increasing population, as well as fewer alternatives for waste disposal, make the pollution control tasks more challenging. Therefore, this topic will focus on assessing and managing environmental pollution. It will cover various subjects, including risk assessment due to the pollution of ecosystems, transport and fate of pollutants, restoration or remediation of polluted matrices, and efforts towards sustainable solutions to minimize environmental pollution.
\r\n\tWater is not only a crucial substance needed for biological life on Earth, but it is also a basic requirement for the existence and development of the human society. Owing to the importance of water to life on Earth, early researchers conducted numerous studies and analyses on the liquid form of water from the perspectives of chemistry, physics, earth science, and biology, and concluded that Earth is a "water polo". Water covers approximately 71% of Earth's surface. However, 97.2% of this water is seawater, 21.5% is icebergs and glaciers, and only 0.65% is freshwater that can be used directly by humans. As a result, the amount of water reserves available for human consumption is limited. The development, utilization, and protection of freshwater resources has become the focus of water science research for the continued improvement of human livelihoods and society.
\r\n
\r\n\tWater exists as solid, liquid, and gas within Earth’s atmosphere, lithosphere, and biosphere. Liquid water is used for a variety of purposes besides drinking, including power generation, ecology, landscaping, and shipping. Because water is involved in various environmental hydrological processes as well as numerous aspects of the economy and human society, the study of various phenomena in the hydrosphere, the laws governing their occurrence and development, the relationship between the hydrosphere and other spheres of Earth, and the relationship between water and social development, are all part of water science. Knowledge systems for water science are improving continuously. Water science has become a specialized field concerned with the identification of its physical, chemical, and biological properties. In addition, it reveals the laws of water distribution, movement, and circulation, and proposes methods and tools for water development, utilization, planning, management, and protection. Currently, the field of water science covers research related to topics such as hydrology, water resources and water environment. It also includes research on water related issues such as safety, engineering, economy, law, culture, information, and education.
",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",keywords:"Water, Water resources, Freshwater, Hydrological processes, Utilization, Protection"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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