Effects of acute alcohol consumption (one BD episode with different BACs) on memory in the studies carried out in this field [37, 39, 42, 43 and 46].
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 179 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 252 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
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Lembrikov is a senior lecturer at the Faculty of Electronics, Electrical and Communication Engineering of the Holon Institute of Technology (HIT), Holon, Israel. B. I. Lembrikov received his Ph.D. in Nonlinear Optics at the Technion – Israel Institute of Technology in 1996. Since then he was an invited researcher at the Haifa University, at the Max Planck Institute High Magnetic Field Laboratory at Grenoble, France, at the Technion, Haifa, Israel. Dr. B. I. Lembrikov is an author of the book \\Electrodynamics of Magnetoactive Media\\, a number of chapters in scientific books, a large number of papers in international peer reviewed journals and reports delivered at the international scientific conferences. He actively participated in a number of research projects concerning optics of nanoparticles, optical communications, UWB communications. The main research fields of interest of Dr. B. I. 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The problem is encountered in all age groups, and the choice of an appropriate technique for removal may, at times, pose a dilemma for the clinician. Although recent reports suggest that most cases of foreign body ingestion do not result in mortality or significant clinical sequelae [4], evidence‐based criteria for management should be employed so as to reduce the risk of potential adverse events. Importantly, cases selected for surgical removal should be appropriately investigated and managed.
\nForeign body ingestion is more prevalent amongst the paediatric age group than in the adult population. The peak incidence is between 6 months and 6 years [4]. The ingestion of foreign bodies is rarely seen in adults; is accidental and is commonly observed in the form of food (meat and bone) ingestion [5]. High‐risk groups among an adult patient population include those with psychiatric disorders, prisoners and intoxicated patients [4]. Intentionally ingested objects typically include common household items (e.g., pens, plastic spoons, toothbrushes or pencils), whereas accidentally ingested items are often food impactions or bones.
\nForeign body insertion, on the other hand, especially involving the lower GIT, is more prevalent in an adult demographic [6]. The true incidence is not known, as many patients do not seek medical attention or management is underreported for obvious reasons [7]. These cases are not limited to a particular demographic, and rectal foreign bodies have been reported in patients of all ages, genders and ethnicities [5, 8]. The mean age at presentation is 44 years but ranges from 20 to over 90 years, with a decidedly higher proportion of male patients (17–37:1) [7]. The most common reason for insertion is anal eroticism, with other reasons, in decreasing order of frequency, being concealment (as in prisoners), attention‐seeking behaviour, assault and “therapeutic” (i.e., attempts to alleviate constipation) [9]. Some literature reports a bimodal age distribution, with the second peak occurring in males in their sixties, often for breaking up faecal impactions or prostatic massage [10].
\nA rational approach to management of gastrointestinal intestinal foreign bodies requires an understanding of the natural course of these ingested or inserted objects. This knowledge is essential to be able to define groups of patients who would require early intervention. Approximately 63–76% of intentionally ingested foreign bodies are removed endoscopically, and the need for surgical intervention ranges from 12 to 16% [4].
\nHistorically, 80% or more of ingested foreign bodies pass spontaneously without the need for intervention [11]. Complications such as impaction, perforation or obstruction occur at areas of physiological narrowing or angulations [12]. Areas of narrowing in the GIT include the upper oesophageal sphincter, aortic arch, left main stem bronchus, lower oesophageal sphincter, pylorus, ileocecal valve and anus; the duodenal sweep is an example of GI angulation [12]. Once foreign bodies have passed through the oesophagus, which is the least expansile aspect of the GIT, most objects pass within 4–6 days or in rare cases in up to 4 weeks [12]. Any anatomical variation in the GIT can alter these series of physiological narrowing and angulations. Therefore, patients with congenital malformations or those who have undergone previous GI surgery are more susceptible to retained foreign bodies [4].
\nThe risk of retention and subsequent complications also varies according to the nature of the foreign body. For example, sharp or pointed objects, fish/animal bones, foil from blister packs, as well as magnets, are associated with an increased risk of perforation [4]. Magnets are especially dangerous as they may attract other simultaneously ingested foreign bodies [13]. Due to their magnetic forces, the objects may adhere to one another across two separate parts of the GI tract leading to severe and potentially fatal complications including volvulus and obstruction, pressure necrosis, fistula formation and perforation [14].
\nImpaction and progressive erosion of the foreign body through the intestinal wall lead to perforation, and, in most cases, this site of perforation is covered by fibrin, omentum or adjacent loops of bowel [12]. The passage of large amounts of intraluminal air into the peritoneal cavity rarely occurs as a result [12]. Retained gastric, intestinal and rectal foreign objects can cause severe injury through this mechanism. The main site of obstruction for rectal foreign bodies is the mid‐rectum as objects are unable to renegotiate the anterior angulation of the rectum. All such retained foreign bodies should, therefore, be treated as potentially hazardous [8].
\nA clinical classification of gastrointestinal foreign objects into oesophageal, gastric, intestinal or colorectal foreign bodies is based on the location of the object within the GIT. Objects may also be classified as ingested foreign objects or foreign body insertions using the mechanism of entry as criteria for classification. Further sub‐classifications of ingested foreign objects into groups of blunt objects, sharp pointed objects, long objects, food bolus impaction and objects containing poisons are useful in defining the management approach [12].
\nForeign body insertions into the rectum may be voluntary or involuntary. The intent may be sexual or non‐sexual. Using this two‐tier classification system, rectal foreign bodies are classified as voluntary sexual, voluntary non‐sexual, involuntary sexual and involuntary non‐sexual. The most common category of inserted objects is that of voluntary sexual insertions and includes plastic/glass bottles, vegetables, wooden or rubber objects and sex toys [15]. Cases of insertion of involuntary sexual foreign bodies are almost exclusively limited to the domain of rape and sexual assault [15]. Involuntary non‐sexual insertions (e.g., thermometers and enema tips) are found in the elderly, children or the mentally ill, and are often accidental [15]. The term “body packing” represents a form of voluntary non‐sexual insertion and refers to smuggling of drugs by concealment in the GIT [12]. For example, illegal drugs (most often cocaine or heroin) are packed within latex condoms or balloons and are swallowed or inserted into the rectum in several parcels [12, 16]. These parcels pose a significant health risk as intoxication secondary to rupture can be potentially fatal. Alternatively, the American Association for the Surgery of Trauma Rectum Injury Scale may be used to assess injury from rectal foreign bodies [7].
\nPatients with gastrointestinal foreign bodies (either inserted or ingested) are often asymptomatic. Alternatively, they may present with a broad range of symptoms, which, vary based on the location, physical characteristics and the content of the object [5]. Most rectal foreign objects are introduced through the anus; however, sometimes, a foreign body is swallowed, fails to pass fully through the GIT, and is held up in the mid‐rectum [10]. Patients with foreign bodies introduced through the anus are often embarrassed about their condition and may be reluctant to seek medical care [17]. In most cases, the patients present to the emergency room after failed efforts to remove the object at home [8]. The time interval from insertion to hospital presentation varies, and may be up to 2 weeks [9].
\nThe medical history is highly critical in the management of foreign body ingestion or insertion [5]. The planning of diagnostic workup and the extent and urgency of a possible intervention are primarily decided according to the information provided by the patient regarding the type of object inserted, together with clinical complaints and findings [5]. However, the main difficulty encountered is that of patients’ reluctance to divulge the nature of insertion/ingestion. For example, patients with rectal foreign bodies are often embarrassed about their condition and may seek to conceal some relevant facts leading to extensive workups and further delays [18]. A high index of suspicion is required to accurately diagnose their condition. At the same time, the practitioner should try to establish the mechanism of insertion. In one case report, the rectal injury was caused not by the foreign object itself, but by another object used as an introducer [19].
\nIt is pivotal to maintain professionalism and courtesy while simultaneously obtaining an accurate, detailed history. For communicative adults, history of ingestion including timing, type of ingested foreign body and onset of symptoms are often reliable [20]. One must also consider whether such case of involuntary insertion constitutes an assault, for the management of the latter requires other medicolegal considerations. For example, it is essential to keep medical photographs of retrieved rectal foreign bodies for clinical records in cases of assault and child abuse [6]. The clinician should also be prepared to provide emotional support for the patient, and have a chaperone in the room when performing the physical examination [7].
\nEven in good historians, physical examination is mandatory to out rule potentially hazardous complications such as small‐bowel obstruction or perforation. Signs of GI perforation may include tachycardia, subcutaneous crepitus and peritonitis. A medical consultation is required if systemic toxicity is due to ingestion of foreign objects [4]. A respiratory examination is necessary to assess for the presence of wheezing or crepitations suggestive of tracheal compression or aspiration, respectively. Specific other presentations are based on the anatomical region where the foreign body is located.
\nPatients with oesophageal foreign bodies, particularly impacted food boluses, can specify the onset of symptoms and if symptomatic may attempt to localise their discomfort exactly. However, the area of discomfort does not always accurately correlate with the site of impaction [4]. The typical complaints in symptomatic patients include a vague report of the sensation of something stuck in the centre of the chest or sudden onset of the difficulty of swallowing during eating. If they report the same sensation in the epigastric region, it may indicate that the foreign body has passed the lower oesophageal sphincter. When the foreign body has passed the oesophagus, the majority of patients remain asymptomatic but a sensation of foreign body, with dysphagia, can persist for several hours and thus can mimic a persisting foreign body impaction [12].
\nDysphagia is another commonly reported symptom, and in the presence of drooling, especially in paediatric cases, may indicate an oesophageal obstruction. Patients with oesophageal foreign bodies may also present with respiratory symptoms such as a cough, stridor or dyspnea. These symptoms may occur as a result of a direct tracheal compression by the foreign body or indirectly due to aspiration of secretions. Non‐specific symptoms, such as abdominal pain or distension, nausea and vomiting, haematemesis or melaena, may be present. If the pericardium and myocardium are involved, the patient may present with acute onset chest pain secondary to mediastinitis or may complain of dyspnoea or severe odynophagia. Such cases are associated with significant morbidity and are recognized causes of mortality [21].
\nOnce foreign bodies have passed through the oesophagus, they are usually asymptomatic, unless obstruction or perforation occurs. Symptoms suggestive of obstruction include abdominal pain, distension, vomiting and constipation. The presence of severe abdominal pain that is intensified by movement, fever and/or rigors makes a diagnosis of gastric or small‐bowel perforation more likely. The clinician may also be able to predict the level of obstruction based on clinical history alone. For example, in small‐bowel obstruction, the pain tends to be colicky in nature, as opposed to large‐bowel obstruction that is usually associated with a more constant pain. For more proximal obstructions, vomiting tends to present before constipation, whereas the opposite is more consistent with distal GIT obstructions. Non‐bilious vomiting indicates that the obstruction is above the level of the ampulla of Vater. Bilious vomiting occurs when the blockage is below this level, and faecal vomiting is more indicative of distal bowel obstruction. In the presence of obstruction or perforation, the typical findings on physical examination include abdominal distension and tenderness; additional peritoneal signs of rigidity or rebound tenderness make the diagnosis of perforation more likely.
\nBecause of the wide variety of objects and the variation in trauma caused to local tissues of the rectum and distal colon, a systematic approach to the diagnosis and management of rectal foreign bodies is essential [15]. Common complaints include rectal or abdominal pain, constipation or obstipation, bright red blood per rectum or incontinence. Complications such as bowel obstruction may also occur [6]. Sudden, excruciating pain during defecation should arouse suspicion of a penetrating foreign body that is usually lodged at or just above the anorectal junction [7]. The presence of a chocolate malodorous rectal mucoid discharge signifies necrosis, perforation and/or sepsis [6]. Other manifestations depend on the size and shape of the foreign body, its duration in situ and the presence of infection or perforation.
\nPhysical examination should include a careful abdominal examination to assess for signs of peritonitis or the ability to palpate an object trans‐abdominally [15]. Abdominal examination is usually followed by a digital rectal examination. However, some authors advise that an abdominal X‐ray should be performed before the rectal examination to prevent inadvertent, accidental injury to the surgeon from sharp objects [15]. A digital rectal examination estimates the distance of the foreign body from the anal verge, as well as assesses sphincter integrity. Sphincter injury is rare in cases of voluntary insertion. However, muscular spasm induced by the foreign body may result in increased sphincter tone. The sphincter may have obvious damage with visible injury to both the internal and external components and should be carefully examined [15]. Most foreign bodies are usually palpable on the digital rectal examination as they are most commonly lodged in the mid rectum.
\nRadiological assessment is the key to further evaluation following a thorough history and clinical examination. For anorectal foreign bodies above the sacral curve and rectosigmoid junction, further evaluation with rigid or flexible proctosigmoidoscopy should be performed if the rectal object is not palpable. Laboratory tests are of limited value and should be limited to a basic pre‐operative work, allowing for timely surgical management if appropriate [7, 15]. Patients with peritonitis or perforation should be kept nil by mouth and resuscitated with intravenous fluids and antibiotics [15]. A nasogastric tube should be considered, and Foley\'s catheter should also be passed [15]. Anti‐thromboembolic prophylaxis should be commenced early and continued until discharge, particularly in elderly patients.
\nPlain radiographs are the first line radiological investigation as they are inexpensive and associated with reduced radiation exposure. Most true foreign bodies are radio‐opaque but smaller thinner objects are not always detected [12]. Metal objects tend to be easily identified, whereas small bone or glass or wooden objects are less readily detected. Serial radiographic studies can be used to determine the passage of the foreign body and the complications resulting from it [5]. Biplanar imaging may be necessary if the history suggests foreign body ingestion but there is nothing detected on initial plain radiograph [12]. Complications such as aspiration, free mediastinal/peritoneal air or subcutaneous emphysema may also be detected on chest X‐ray in a limited number of cases [12]. X‐ray is not sufficient and not required in patients with non‐bony food bolus impaction and without clinical signs of perforation [12].
\nThe use of barium swallow as part of the workup for a patient with ingested foreign body is not advised [12]. It is associated with an increased risk of aspiration and may obscure visualization if subsequent endoscopy is indicated. If an upper GI foreign body is not detected on plain films, then an oral contrast medium (e.g., gastrograffin) may be considered, assuming oesophageal obstruction has been out ruled [12]. Computed tomography (CT) of the abdomen and pelvis is especially useful when radiolucent materials cannot be detected with plain X‐rays [5]. It may also be considered if the rectal foreign body has been in place for more than 24 h [8]. This modality has largely supplanted the previous contrast studies. The risk of potential complications increases if the foreign body has been in place for more than 24 h. With CT, the shape, size, location and depth of the impacted foreign body and the surrounding tissue can be visualized, which is important in determining treatment. Of note, free intraperitoneal air is a poor radiological sign [12]. The region of perforation can be identified on CT scan as a thickened intestinal segment, localized pneumoperitoneum, regional fatty infiltration or associated obstruction [12, 22].
\nConservative outpatient management, on the one hand, is appropriate for asymptomatic patients with blunt objects in the stomach that are smaller than 2–2.5 cm in diameter and 5–6 cm in length [12]. As a rule, objects greater than 2.5 cm in diameter will rarely pass through the pylorus or ileocecal valve and objects longer than 6 cm will also rarely pass through the duodenal sweep [12]. Patients who are to be managed conservatively should be educated about the symptoms of potential complications and instructed to represent if they occur [12]. Of particular importance are those related to perforation or obstruction. They should also be instructed to check their bowel motions to monitor for spontaneous passage of the foreign body [12]. If the foreign body fails to pass beyond the stomach within 4 weeks, it is likely to require intervention [4, 12]. Conservative in‐patient management, on the other hand, is recommended for “body‐packers” with a failure rate of only 2–5% [12]. The management comprises clinical observation, whole bowel irrigation and radiographic follow‐up for observing passage of the parcels [12].
\nRecently, the European Society of Gastrointestinal Endoscopy (ESGE) published guidelines for foreign body management [12]. According to their guidelines, the timing of endoscopic intervention is divided into three groups: emergency, urgent and non‐urgent. Patients who are unable to manage their secretions on presentation, those who swallowed disk batteries and those with sharp objects in the oesophagus will require emergent endoscopic intervention (preferably within 2 h, but at latest within 6 h) [12]. Urgent (within 24 h) endoscopy is recommended for removal of oesophageal foreign objects that are not sharp‐pointed, food impaction without complete obstruction, sharp pointed objects in the stomach or duodenum and objects longer than 6 cm in length and magnets within endoscopic reach [12]. As delay decreases the likelihood of successful removal of such objects and increases the risk of complication, endoscopic removal should not be delayed beyond 72 h even for the non‐urgent cases [12]. Cases suitable for non‐urgent management include coins in the oesophagus which may be observed for 12–24 h before endoscopic removal in an asymptomatic patient [4]. Cylindrical and disk batteries that are in the stomach of patients without signs of GI injury may be observed for as long as 48 h before proceeding with endoscopic removal [4]. Batteries remaining in the stomach longer than 48 h should be removed before 72 h as well as objects in the stomach with a diameter greater than 2.5 cm [4].
\nIn practice, conscious sedation may be used for endoscopic removal in adults, but endotracheal intubation under general anaesthesia is often required for objects that are harder to remove. Standard‐sized overtubes that extend past the upper oesophageal sphincter not only protect the airways but also facilitate passage of the endoscope during removal of multiple sharp, pointed objects or piecemeal extraction of an impacted food bolus [12]. Overtubes help to reduce further potential damage to the mucosa of the GIT while the foreign body is being withdrawn. The specific example of removal of food bolus may simply involve gently pushing the bolus into the stomach with success rates of over 90% and minimal complications [12]. However, extraction may also be performed using grasping forceps, retrieval graspers, polypectomy snare, basket and retrieval nets. Other blunt objects such as coins, buttons, toys, batteries and magnets can also be removed using a similar range of retrieval devices. Long objects including strings, cords, pen, pencils, toothbrushes, cutlery and screwdrivers are best removed using polypectomy snares or baskets. A transparent cap and latex rubber hood may be required additionally for removal of sharp pointed objects. If the foreign body cannot safely be retrieved endoscopically, in‐patient treatment and close clinical observation are mandatory.
\nBleeding can also be encountered as a complication of ingestion or endoscopic removal of sharp pointed objects. The principle of successful management is by meticulous resuscitation, accurate endoscopic diagnosis and timely application of appropriate therapy. The endoscopic and surgical management is similar to that of bleeding peptic ulcers. For example, ulcers with a clean base or non‐protuberant pigmented dot in an ulcer bed, which are at low risk of re‐bleeding, do not require endoscopic treatment [23]. For all others, including those who have active bleeding or non‐bleeding visible vessels or have adherent blood clot, endoscopic treatment should be administered [23]. Injection with 1:10,000 adrenaline around the bleeding point and then into the bleeding vessel achieves haemostasis in up to 95% of cases [23]. Additional injection of sclerosants or absolute alcohol does not confer additional benefit. Fibrin glue and thrombin may be more effective, but they are not widely available. Heater probes, multipolar coagulation (BICAP), argon plasma coagulation or mechanical clips may also be used but consulting a gastroenterologist may be more appropriate at this stage. Repeat therapeutic endoscopy may be attempted if there is a suggestion of further active bleeding or in cases where the initial endoscopic treatment was sub‐optimal. Operative intervention is mandatory if initial control of bleeding is not possible endoscopically and techniques are as described in standard surgical texts.
\nBesides for failure to control bleeding endoscopically, there are other indications for surgical intervention. Urgent cases include cases of ruptured narcotic packets or leakage, presentations with clinical evidence of peritonitis and intestinal obstruction. Non‐urgent indications for surgery include scenarios in which endoscopic removal is challenging such as trichobezoars [24], or if the object has failed to progress along the GIT and is not accessible by endoscopy [25–27].
\nAccess in all cases is through an upper midline incision. The abdominal wound is also protected to minimize the risk of wound infection. Subsequent surgical removal of gastric foreign bodies will involve a transverse gastrotomy away from the pylorus and between the lesser and greater curve of the stomach (Figure 1).
\nTransverse gastrotomy for removal of foreign bodies.
Objects impacted at the duodenal sweep can be removed through a duodenotomy if they cannot be milked back to the stomach. Similarly, impacted objects in the small bowel can be removed through enterotomies. Primary closure is indicated in cases without peritoneal contamination. For closure, it is important to avoid narrowing the lumen. Techniques similar to that of pyloroplasty involving transverse incisions with longitudinal closure using absorbable sutures should be considered (Figure 2).
\nTechnique of pyloroplasty.
Perforated cases are often contained, so a primary closure or segmental resection of the affected small bowel may still be possible provided the tissues remain healthy (Figure 3).
\nSegmental bowel resection and anastomosis.
Diversion may be reasonable in cases of delayed presentation, or where grossly faecal contamination has occurred, and the tissues are unhealthy. The stoma can be reversed at a later date (after 3 months usually). The use of intra‐abdominal drains may be limited to the surgeon\'s preference. Postoperative care should follow the lines of enhanced recovery following upper gastrointestinal surgery.
\nAlthough sealed perforation involving degradable food matter can be treated non‐surgically in the initial instance, such a policy requires careful interval assessment by an experienced surgeon with a low threshold for performing laparotomies if clinical improvement is not apparent both to confirm the diagnosis and oversew an unsealed perforation [28]. In most cases, however, the treatment of choice for patients with perforation of the duodenum is laparotomy, peritoneal lavage and simple closure of perforation, usually by omental patch repair [23]. The initial step of the repair involves placement of full‐thickness bites at approximately 0.5 cm away from the edges of the perforation, and the defect is left untied (Figure 4A).
\nPlacement of sutures for omental patch repair.
Final repair of a duodenal perforation with an omental patch.
A patch of omentum is then brought without tension and positioned over the perforation, and the sutures are successively tied to secure the omentum onto the defect itself (Figure 4B).
\nIn cases of “giant” perforation, where the defect measures 2.5 cm or more, partial gastrectomy with closure of the duodenal stump should be considered [23]. Alternatively, in situations where the clinical situation or expertise dictates more expeditious surgery, the duodenal perforation should be closed as well as possible around a large Foley or T‐tube catheter to create a controlled fistula [23]. Other methods described include a free omental and jejunal serosal “plug” [23].
\nIt is essential to remove all retained anorectal foreign bodies [8]. However, extraction of rectal foreign bodies may be challenging. The medical literature confirms the diversity of the problem, and equally some ingenious solutions [19, 29–40]. Techniques described range from simple digital extraction to complicated surgical removal. Several algorithms for management have also been proposed [6, 7, 29], with a tendency to progress from least to most invasive as required [7]. This approach will result in the best chance of success with the lowest risk to the patient [7].
\nUnless signs of peritonitis are present, or the patient is unstable, both of which necessitate emergency laparotomy, an initial attempt at bedside extraction is advised [15]. Bedside extraction is successful in 60–75% of cases [7]. A variety of tools can be used as adjunct retrieval devices including obstetric forceps, ring forceps, Kocher clamps, suction devices and various grasping forceps. The instruments used vary according to the characteristics of each case. For example, in cases where the rectal foreign body has created a seal with the rectal mucosa [15], a balloon catheter such as a Foley may be used to pull the foreign body distally along the GIT [41–44]. The Foley is inserted, deflated and passed proximally to the retained object, then inflated and subsequently pulled to drag the foreign body along the bowel. This technique is useful in cases in which the rectal lumen is obstructed by a smooth foreign body. The foreign body results in a negative pressure differential on the proximal rectal lumen. By inserting the Foley above the area, the pressures will equalize and help facilitate the removal. Alternatively, obstetric vacuum extractors may be used to grasp the object, widen the anal canal and release the rectal seal [45–47]. It is pertinent to note that body packers should have potentially toxic packages removed with digital rectal examination only, tools and endoscopic devices should be avoided as they increase the risk of damage to the parcel and leakage/absorption of its’ contents. Any systemic signs of perforation may warrant laparotomy with the subsequent supportive care of any overdose geared towards the drug ingested. The use of enemas and stimulants to propel the object distally is not recommended, as these may cause further damage to the rectal wall [7].
\nSurgeons have higher success rates at bedside transanal extraction than emergency physicians [48]. The exact reasons for this are unclear, but may represent a willingness to be more aggressive in attempts to remove the object and due to the ability to fix resultant damage in the theatre [7]. In general, predictors of failure of transanal extraction of retained rectal foreign bodies include objects longer than 10 cm, hard or sharp objects, those that have migrated into the sigmoid colon as well as those that have been retained for more than 2 days [6, 48].
\nWhen attempting to remove a rectal foreign body transanally, the most important factor in successful extraction is patient relaxation [15]. This can be achieved with a perineal nerve block, a spinal anaesthetic or either of these in combination with intravenous conscious sedation [15]. After the patient has been appropriately sedated and anaesthetized, attempts should be made to remove the object [15]. The high lithotomy position in Candy Care Stirrups in the operating theatre facilitates the removal of most objects and has the added benefit of allowing for downwards abdominal pressure to be applied to aid in the extraction of a foreign body [15]. The anal canal should be gently dilated to three fingers’ breadth before transanal delivery [15]. A reverse Trendelenburg angulation may also be attempted. The technique of bimanual extraction helps move an object caudally and also prevents cephalad migration with difficult to grasp objects [7]. Blind insertion of instruments should be avoided as it can hinder the removal of the foreign body and induce rectal injuries or perforation [49].
\nFlexible sigmoidoscopy is required for objects that are located more proximally in the rectum or the distal sigmoid colon, which are often not amenable to removal by per digital rectal examination or with the tools mentioned earlier [29]. Endoscopy produces an additional means of non‐operative extraction, thereby limiting operative intervention in some cases. Removal of sharp objects can pose an extra risk to both the patient and the surgeon, but direct visualization with rigid or a flexible endoscopy has helped to mitigate this problem [9, 15]. This excellent visualization of the mucosa with endoscopy also helps to evaluate for subtle and gross changes in the rectal mucosa [15]. Polypectomy snares may be used to “lasso” objects [18, 50] or objects may be grasped by grasping forceps using endoscopic methods. Removal under general anaesthesia is attempted when endoscopic removal under sedation is not successful. It is worth mentioning that all patients undergoing removal of foreign objects under general anaesthesia should also consent for laparoscopy or laparotomy should the first attempts fail [29].
\nSurgical removal (laparotomy or laparoscopy) is indicated in patients with systemic signs or radiological evidence of perforation. Additionally, surgery may also be performed as a last resort when anal dilatation, manual or forceps extraction have failed to remove the foreign body [29]. The surgical options for a failed transanal extraction vary from minimally invasive techniques to open surgery. Evidence for use of each technique is limited to case series and reports. For the laparoscopic‐assisted techniques of removal, the object is milked inferiorly with direct intra‐abdominal visualization using a laparoscope and grasper that aids in the eventual transanal extraction [51]. Similarly, a lower midline mini‐laparotomy may be used to squeeze the rectum directly and allow transanal removal [52]. Ultimately, if these attempts remain unsuccessful, a colotomy with transabdominal removal can be performed [7]. This is also the technique usually required in an emergent setting where perforation has occurred [7]. If gross contamination or spillage is present, a Hartmann procedure may be the prudent option [7]. However, if tissue quality is good, a primary repair or short segment resection may be performed, and the repair is tested for a leak using protoscopy [8]. This approach is well supported in the trauma literature with experience of blunt and penetrating trauma [7]. Further, the evidence from trauma literature shows that severe faecal contamination, transfusion of more than three units of blood, and single‐agent antibiotic prophylaxis are independent factors for abdominal complications following surgery for colorectal trauma [53].
\nFurther notes on the management of rectal perforation are presented here. When patients present with a rectal perforation, they should, at first, be stabilized as with any trauma patient [15]. After stabilization, management depends on three factors: first, whether the patient is clinically stable or unstable, second, whether the perforation is in an intraperitoneal or extraperitoneal location, and last, whether there is significant fecal soilage or not [15]. Preoperative CT scan is required. A well‐established order for the management of a rectal perforation secondary to a foreign body is diversion, debridement, distal washout and drainage [15]. Unstable patients, those with multiple comorbidities, those with significant tissue damage and those with delayed presentation more often require a diversion [15]. On the other hand, a primary repair and washout is suited for patients who present early, those with minimal tissue damage and those with little to no contamination [15]. Small extraperitoneal injuries can be managed with observation, avoidance of enteral feeding and antibiotics [15]. However, laparoscopic approach has been successfully applied in the treatment of colonic perforations, and operative outcomes are similar to open procedures in selected patients [15]. In cases of rectal perforation secondary to foreign body insertion, the operator must be aware of the possibility of secondary or occult organ injury. The small bowel, uterus, bladder and sigmoid colon should all be assessed preoperatively. It is also important that a full consent process outlining risk of a stoma is discussed before the patient is anaesthetized. Failure to do so may result in patient dissatisfaction with treatment and complaints.
\nIf none of the above measures are successful, specifically in cases of large objects tightly wedged in the pelvis, the next logical step would be to carry out a symphysiotomy [8]. A symphysiotomy involves attempts at expanding the pelvic volume to facilitate the passage/removal of larger objects. Such a description may, however, be a historical anecdote rather than acceptable correct surgical practice.
\nIf the ingested foreign bodies are not or cannot be removed, a case‐by‐case approach depending on the size and type of the foreign body is suggested [12]. A patient may be discharged if a successful and uncomplicated endoscopic removal of ingested foreign bodies has been achieved [12]. Other groups of patients including those with significant co‐morbidities, delayed presentation, difficult extraction or haemodynamically unstable post‐extraction may require further clinical observation. Post‐extraction repeat endoscopy and plain radiographs should be considered before discharging any such patient [18, 48].
\nPsychological evaluation before discharge should be considered in the setting of intentional ingestion. This assessment may help reduce recurrent presentations. In cases of sexual assault, long‐term psychological consequences may occur, and therefore, early involvement of mental health services and counselling is warranted [6]. Children in whom a non‐accidental injury is suspected should be referred to a paediatrician for further evaluation, and legal authorities should always be informed in every case of suspected assault [6]. The aim is to offer support to victims of assault and abuse [18, 54]. Additionally, the patients should be examined for the use of alcohol and narcotic drugs.
\nPostoperative pain control, early ambulation and diet initiation upon return of bowel function should follow guidelines for any general surgical intervention [8]. For patients who underwent surgical extraction, the discharge should be considered when bowel physiology returns [8]. For anorectal foreign bodies, it is of paramount importance to inspect the distal colon endoscopically to out rule any unintentional injuries upon successful extraction [10, 18]. It is also important to document sphincter function post‐extraction [7]. Although bleeding lacerations in the rectal mucosa are self‐limiting, perforation resulting in sepsis and multisystem organ failure can occur [15]. If there is any clinical suspicion, a CT scan with rectal contrast or rectal enema with water‐soluble contrast can detect this potentially life‐threatening complication [7]. After diagnosis, stable patients may be managed with antibiotics [7]. Patients with signs of toxicity including fever, hypotension or severe pain should be managed by surgical exploration [7]. Depending on the level of perforation, options for surgical management are similar to those previously described above [7].
\nSignificant trauma or damage to the anal sphincter can also result in mild to severe faecal incontinence. There are no good long‐term studies, and few articles describe long‐term follow‐up [7]. One series included a telephone survey of 30 patients with a previous retained foreign body. None had any incontinence to solid, liquid or gas with a follow‐up ranging from 8 to 96 months [55]. Although uncommon, complications from sphincter damage may include fistulas and stenosis [56]. Cases of sphincter dysfunction (including incontinence) are often initially managed conservatively; any injury is left open, and further assessment is undertaken in an elective setting [7]. A follow‐up of at least 3 months is recommended before considering any sphincter repair [17]. If symptoms persist, a delayed sphincteroplasty may be performed with good results [57].
\nIn keeping with the inquisitive nature of humans, there are a wide variety of foreign body presentations encountered in clinical practice across all age groups. Although there may be anecdotal or interesting clinical scenarios of ingested or inserted foreign bodies, one can never underestimate that there is a significant morbidity and unfortunately, mortality associated with these cases. The retrieval of upper gastrointestinal foreign bodies is a more described pathway in the literature. The removal of rectal foreign bodies often requires a wide variety of approaches, many of which are individualized. Surgery may be necessary in some patients.
\nBirk M, et al. Removal of foreign bodies in the upper gastrointestinal tract in adults: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2016;48:1-8. https://www.thieme‐connect.com/products/ejournals/html/10.1055/s‐0042‐100456.
\nPresentations due to gastrointestinal foreign body ingestion or insertions are common emergency clinical scenarios. The majority of these objects will pass spontaneously, and others will require endoscopic or surgical intervention for removal.
Absolute indications for abdominal surgery include those patients with clinical peritonitis from perforation. Other indications for surgery include bowel obstruction and failure of conservative or endoscopic management.
Surgical technique for removal of a gastric foreign body involves a transverse gastrotomy with incision away from pylorus and between the lesser and greater curvature of the stomach. Retained intestinal or colonic foreign bodies may also be removed through enterotomies or colostomies. Primary closure is indicated in the absence of peritoneal contamination, and it is important to avoid narrowing the gut lumen during closure.
In the case of peritonitis due to gut perforation, a primary repair or short segment resection of enterotomy or colotomy may be appropriate after a thorough washout of the abdomen if the tissue quality is good. Diversion of the gut may be required in cases of delayed presentations, significant faecal contamination and signs of sepsis.
Foreign body insertions represent a challenging and unique field of colorectal trauma. A careful history and examination is essential in the diagnosis. However, rectal examination may best be performed after an abdominal X‐ray to prevent inadvertent, accidental injury to the surgeon from sharp objects.
Bimanual extraction under anaesthesia is the technique of first choice when bedside extraction fails. Other options for removal under anaesthesia will include anal dilatation, laparotomy or laparoscopy. A colotomy may be required for removal when the object cannot be milked down for transanal extraction. A Hartmann\'s procedure may be necessary in cases of significant faecal peritonitis.
It is important to document sphincter function post‐extraction of a rectal foreign body. Recto‐sigmoidoscopy is advised to assess the rectal and distal colonic mucosa to determine the extent of any possible injury and exclude perforation.
Cases of sphincter dysfunction after removal of a rectal foreign body are often initially managed conservatively, and the majority will resolve without any intervention. For those not settling, referral to a specialized colorectal surgery/incontinence unit is recommended and may require a delayed sphincteroplasty.
Alcohol is one of the most widely consumed psychoactive substances in the world, especially among adolescents and young adults [1, 2]. Many of these develop a pattern of alcohol consumption known as binge drinking (BD). BD has been defined by The National Institute on Alcohol Abuse and Alcoholism (NIAAA) as a pattern of drinking that elevates a person’s blood alcohol concentration (BAC) to 0.8 g/L or above [3]. This pattern involves the intake of large quantities of alcohol in a short period (about 2 h), followed by a period of abstinence, with a variability between 1 week and 1 month (see Figure 1). BD is the most common pattern of alcohol use among adolescents and young adults in Western countries. In Spain, the prevalence of BD pattern is similar in both sexes among 14–16 year-old adolescents and is more widespread among men than women in the age range of 17–18 years [4].
(a) Binge drinking pattern criteria. Quantity: intake of 50–56 g of pure alcohol in women and 60–70 g in men, in 2 h. Frequency: at least one BD episode per month. Intermittency: abstinence between BD episodes over time (minimum 1 week, maximum 1 month). (b) Number of drinks (1 drink = SDU, standard drink unit) in the USA and Europe for binge drinking’s BAC levels.
Individuals engaging in frequent BD have an increased risk to develop an alcohol use disorder (AUD) later in life. This risk has been suggested to be linked to executive deficits (e.g., [5]). The BD pattern of consumption seems to be especially associated with increased impulsivity and inhibitory control deficits (e.g., [6, 7, 8]). At the same time, this seems to be due to an attenuated frontal activation (e.g., [8, 9]). Thus, a higher incidence of BD has been related to decreased activation of dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and anterior cingulate cortex, brain regions strongly implicated in executive functioning [9]. The neurotoxic effects of BD on these regions can be less evident throughout adolescence, but if this alcohol consumption pattern persists, the executive dysfunction could be exacerbated. While individuals with AUD typically exhibit inhibitory control dysfunction, evidence of impaired inhibitory control among binge drinkers, who are at increased risk of developing an AUD, is mixed. Despite the variability in the literature, some findings point to mechanisms that may confer vulnerability for transition from binge drinking to AUD [6]. Therefore, inhibitory control deficits must be considered as an important factor that contributes to alcohol abuse.
On the other hand, important physical, social, and cognitive skills are acquired during adolescence and early youth. This period is also characterized by critical changes to the structural and functional development of brain areas related with these skills [10]. For example, the superior associative cortex (e.g., prefrontal cortex) undergoes myelination, pruning, and synaptic reorganization [11, 12], among other alterations. Significant changes in the volume and shape of the hippocampal complex, a brain region that plays an important role in memory functions, are also observed during this developmental period [13, 14, 15].
Due to this plasticity, the adolescent brain seems to be especially vulnerable to the neurotoxic effects of alcohol. In fact, alcohol-related performance deficits in tasks assessing cognitive processes, such as attention, memory, and executive functions, in the not-yet-adult brain are more evident during adolescence [16, 17] and become more pronounced with a BD pattern of consumption [12, 18].
The intermittence between BD episodes seems to be the most important factor involved, as the repeated alternation between intoxication and withdrawal is particularly deleterious for the brain, due to the excitotoxic cell death it provokes [19, 20]. Thus, it has been demonstrated that BD episodes can be more harmful for the brain than an equivalent amount of alcohol without withdrawal episodes [20, 21].
Therefore, the BD adolescent population constitutes a cohort at risk of brain damage, and any disruptive effects of alcohol on learning and memory abilities in this age group could have a particularly deep impact and last through to adulthood. Moreover, females would seem to be more vulnerable to these detrimental effects of alcohol [22].
In the following sections, the main insights provided by studies performed by our group and other researchers about the effects of BD on learning and memory performance will be discussed. We focus on the types of memory that are most damaged by alcohol: immediate visual memory (IVM) and working memory (WM). One distinctive contribution of this chapter is to evaluate, together, the impact of an acute BD episode and the sample’s history of consumption on learning and memory performance, as well as the possible gender differences at play.
For this review, we conducted a literature search of three databases: Web of Science, PsycINFO, and PubMed. The following combination of key terms was used: binge/heavy/social OR adolescent/young OR blood alcohol OR immediate/working/memory OR alcohol/ethanol OR cognitive AND acute alcohol. These keywords were examined in the “title” section for Web of Science and PsycINFO and “title/abstract” sections for PubMed. We considered studies published in English since 2000 (1 January 2000–30 November 2018) in humans. The total number of studies identified through the initial database searching was 677 (Web of Science, 284 records; PsycINFO, 215 records; PubMed, 178 records). Duplicated records were removed, and other articles were excluded using strict exclusion criteria: no BD pattern, out of age range (18–35 years old), psychiatric disorders, and other criteria described in the “methods” section. Eventually, 15 full-text articles were included in this review (see Figure 2 and Table 1). This review is limited by the publication bias (databases not included), procedure of selection bias, and unavailable data.
Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram showing how articles were selected for review.
The experimental subjects in our studies (e.g., [23, 24]) were adolescent university students, who filled in a self-report questionnaire about consumption of drugs, frequency and level of alcohol consumption, hours and quality of sleep, and physical and psychological health. They were recruited based on strict inclusion and exclusion criteria. The inclusion criteria used were 18–19 years old, a healthy body mass index (between 20 and 25), and good health (without major medical problems). The subjects had to be refrainers (or very occasional alcohol consumers) or binge drinkers. The exclusion criteria were as follows: on medication; a history of mental disorders (diagnosed by a health professional according to DSM criteria); an irregular sleep pattern (non-restorative sleep and/or irregular schedule); having consumed, albeit sporadically, any drug (apart from alcohol) or having a history of substance abuse, including caffeine (our criterion: ≤2 stimulant drinks/day), tobacco (our criterion: ≤10 cigarettes/day), and alcohol (except for the BD consumption pattern); and having first-degree relatives with a history of alcoholism.
Other studies reviewed in this chapter included adolescents and young adults (18–35 years old) selected by similar or less restrictive inclusion/exclusion criteria, considering the alcohol use of subjects (history of problems due to alcohol use) and a history of mental health treatment (e.g., [25]).
Gender differences in the effects of alcohol have been reported, supporting the view that the brains of male and female adolescents are differentially affected by alcohol use [22]. There is evidence suggesting that female adolescents are more vulnerable to the neurotoxic effects of alcohol on cognition [22, 26, 27], since the cognitive tolerance effect of alcohol on IVM develops in BD women but not in BD men [24]. Other authors have found that men generally report lower sensitivity to alcohol (individuals need more alcohol to experience the same sensations or impairments) than women, and reactivity to alcohol-related cues is more pronounced in male than in female binge drinkers (e.g., [11]). These results might at least partially explain why men typically show a higher prevalence of alcohol consumption than women. However, in Spain at least, the incidence of alcohol consumption in 14–18-year-old adolescents is higher among females than males [4], while the BD pattern during adolescence is similar in 14–16-year-old adolescents and is more common among men than women in the age range of 17–18 years [4].
Gender differences in WM have also been reported in healthy young subjects, showing an advantage in this memory among males, with females exhibiting disadvantages manifested by a small effect size in both verbal and visuospatial WM [28]. This male advantage could be due to the activating effects of testosterone [29], though age and specific task modulate the magnitude and direction of the effects (e.g., [28, 30]). However, there are reviews in literature that explore the history of BD consumption but not the acute effects it exerts and which does not support the existence of gender differences in the effects of alcohol on this type of memory (e.g., [31]).
In the light of these data, it would seem crucial to consider (a) including both sexes, men and women, in any studies carried out and (b) evaluating potential gender differences in the relationship between BD and memory in adolescents and young adults.
Selected subjects were invited to participate in our studies if they reported refraining from alcohol consumption (or having indulged in very sporadic consumption) or a history of alcohol use classified as a BD pattern according to the NIAAA criteria for Spain (see [12]). Subsequently, the participants were classified as fulfilling a BD pattern if they had drunk six or more standard drink units (SDU) in the case of men or five or more SDU in the case of women on a minimum of two or three occasions per month throughout the 12 months prior to the survey. In Spain a SDU = 10 g of alcohol of distilled spirits (alcohol content ≥40% vol.). It is important to clarify that a stable BD pattern maintained over the time (12 months in the case of our studies) is a crucial criterion, because repeated alternation between intoxication and abstinence has been shown to be particularly harmful to the developing brain [19, 20]. Participants were classified as refrainers if they had never consumed alcoholic beverages or had drunk very sporadically (<1 SDU on <3 occasions per year, for example, 250 ml of beer, per occasion) since the onset of their alcohol use.
Therefore, in the studies reviewed in this chapter, including ours:
The experimental subjects were nondependent individuals indulging in alcohol use, usually evaluated by the Alcohol Use Disorders Identification Test (AUDIT) or others, such as the brief Michigan Alcoholism Screening test (e.g., [25]).
A very noticeable factor is the variability both in the samples’ history (refrainers, habitual consumers, binge drinkers, light binge drinkers, etc.) and in the acute administration of alcohol that leads to a BAC of 0.8 g/L (see Table 1 “sample’s history of consumption” and “cognitive performance—with (BAC)—” entries for details).
Depending on the study, performance in the memory task was registered as either rising or declining BACs.
Taking into account the scarcity of studies evaluating acute alcohol consumption in adolescent and young adult refrainers or occasional consumers (e.g., [23]), the present chapter provides unique insights into this field of research.
In our studies, the third edition of the Wechsler Memory Scale (WMS-III; version adapted for the Spanish population) [32] was used to assess IVM and WM. The IVM subscales require the respondent to recognize faces and remember scenes, while the WM subscales require the respondent to put letter-number sets in order and to reproduce visual-spatial sequences. The literature reports a poorer performance in these types of memory under the acute effects of alcohol (e.g., [24, 33]) and especially in WM associated with a stable BD maintained in time (e.g., [34]).
Other scales used for the evaluation of these or similar types of memory are:
The Cambridge Neuropsychological Test Automated Battery (CANTAB) for evaluating spatial recognition memory. The CANTAB is a computer-based cognitive assessment system consisting of a battery of neuropsychological tests, administered to subjects using a touch screen computer. This battery evaluates several areas of cognitive function using nonverbal stimuli in the majority of its tests, including the pattern recognition memory, a test of visual recognition memory in a two-choice forced discrimination paradigm.
The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) for evaluating long- and short-term memory, working memory, and declarative memory. The ImPACT is a computer-based program for assessing neurocognitive function and concussion symptoms. This neurocognitive test battery consists of several modules for evaluating attentional processes, verbal recognition memory, visual working memory, visual processing speed, reaction time, and numerical sequencing ability.
The Wechsler Adult Intelligence Scale (WAIS-R) with the digit symbol substitution test (DSST) for evaluating short-term memory. The WAIS-R (revised form of the WAIS, a test designed to measure intelligence and cognitive ability in adults and older adolescents) consisted of six verbal and five performance subtests, including the DSST. This subtest (DSST-WAIS-R) consists of digit-symbol pairs followed by a list of digits; under each digit the subject must write down the corresponding symbol as fast as possible within the allowed time.
Obviously, the use of different tests/batteries for evaluating memory contributes to the heterogeneity of results in this field of research.
In our procedure, all participants signed an informed consent and a data confidentiality agreement on arrival at the laboratory. BAC was measured in all subjects with an alcoholmeter to ensure that they had not previously drunk alcohol on the day in question, and the alcohol use of the BD adolescent subjects was assessed using the AUDIT test (none of the subjects was assessed as alcohol-dependent). Next, refrainers and binge drinkers drank 330 ml of lime- or orange-flavored refreshment (control groups), and binge drinkers’ drank a high dose of alcohol. Alcohol was administered in a fixed dose of 120 ml (38.4 g) consisting of vodka mixed with the abovementioned refreshment for both genders or in function of their body weight (0.9 g alcohol/kg body weight in men and 0.8 g alcohol/kg body weight in women). The subjects were instructed to consume their drink within a period of 20 min. After finishing the drink, all subjects rinsed their mouths with water, and BAC was repeatedly measured every 5 min throughout the waiting period, until it reached a peak (approximately 20 min after consuming the drink). This peak of BAC was considered the value with which to classify the participants into the different experimental groups. The subjects performed the IVM and WM tests, while BAC was descendent. BAC was measured once again at the beginning of the tests, between the tests and at the end of the experiment. The BACs registered for the male and female subjects (separately or together) in the different experimental groups were:
0.0 g/L, in refrainers men (n = 17) and women (n = 24) or BD men (n = 23) and women (n = 27). These are control groups receiving a nonalcoholic drink.
0.33 g/L, in refrainers men (n = 17) or BD men (n = 22).
0.38 g/L, in refrainers men (n = 11) and women (n = 11) or BD men (n = 11) and women (n = 11).
0.5 g/L, in refrainers (n = 18) or BD women (n = 24).
0.3–0.5 g/L (mean = 0.4 g/L), in BD men (n = 12) and women (n = 12).
0.54–1.1 g/L (mean = 0.8 g/L), in BD men (n = 14) and women (n = 24).
(Note: The A, B, C, and D experimental groups belong to Ref. 23; and the A, E, and F experimental groups belong to Ref. 24).
All tests were performed between 4:00 pm and 8:00 pm, and the subjects that received alcohol remained on the premises until their alcohol concentration dropped to legal limits for driving (<0.3 g/L).
Similar procedures were applied in the other reviewed studies, where cognitive performance—with (BAC)—was evaluated after alcohol intake administered in fixed doses or according to body weight. Participants also abstained from alcohol for at least 12 h prior to the experiment, as well as drinking coffee or tea on the mornings prior to the experiment, and were instructed to eat a low-fat breakfast and lunch on the day on which tests were performed (e.g., [35]).
The main findings obtained in our experimental investigations and those of other groups are summarized in Table 1. The effects of acute alcohol consumption—one BD episode with different BACs—on different types of memory are reviewed.
A total number of 15 studies are summarized. Only three of them included adolescent male and females (18–20 years old) [23, 24, 33]; the participants in the rest of the studies were in the 18–35-year-old group, without studies comparing adolescents and young adults.
The sample’s history of consumption encompasses a range from refrainers to heavy binge drinkers, including habitual consumers/moderate drinkers and light binge drinkers. This variability in the samples of the reviewed studies gives us a more specific view of the acute effects of alcohol in different types of consumers and not only in binge drinkers.
In general, the results obtained in the evaluated memory tasks confirm the deleterious effects of alcohol use. Significant impairments were observed in spatial recognition memory, WM, associative learning, word fragment completion, free recall, long-term memory, short-term memory, and IVM. However, an absence of effects has also been observed with respect to some of these memories, such as visual memory, short-term memory, WM, and IVM. It is possible that the impairing effects observed are conditioned by BAC (ascendant BAC, BAC peak, descendant BAC) in the case of some types of memory. Thus, in studies in which there were ascendant and descendant BACs, impairment was reported in long-term memory, short-term memory, and WM declarative memory with ascendant BAC but not with descendant BAC.
Finally, the values for cognitive performance—with (BAC)—in Table 1 show the absence of effects or impairing effects in every sample, including for BAC of 0.0 g/L (refrainers and binge drinkers consuming refreshment/placebo). For example, in Vinader-Caerols et al. [23], male IVM performance was refrainers (0.0 g/L) = refrainers (0.33 g/L) = BD (0.0 g/L) = BD (0.33 g/L) and women’s performance was BD (0.0 g/L) < refrainers (0.0 g/L).
The key findings of this review will now be discussed. Among the types of memory reviewed, word fragment completion, free recall, and IVM appear to be the most sensitive to the effects of acute alcohol, as they are affected by moderate doses of alcohol (BAC = 0.3–0.38 g/L) in adolescents and young adults (e.g., [23, 38]). However, higher doses of alcohol (BAC levels of BD, i.e., around 0.8 g/L) are necessary for a significant impairment in other memories, such as WM (e.g., [24]) and short-term memory (e.g., [40]). A plausible explanation for the lack of effects reported with BACs under 0.8 g/L (e.g., [23, 25, 40, 44, 45]) is that the brain of binge drinkers employs compensatory mechanisms in additional brain areas to perform the tasks adequately and that these resources are undermined at higher BACs (e.g., [24, 33, 36, 40, 41]).
In contrast to the present review, others have attempted to provide an overview of affected (and unaffected) neuropsychological functions in adolescents and young binge drinkers, without evaluating the acute effects of alcohol and considering only the subjects’ history of BD (e.g., [31]). However, the interaction between a BD history of consumption and the effects of acute alcohol exposure on learning and memory needs to be studied, as some long-term effects of repeated alcohol exposure in adolescents (such as alcohol tolerance or damaged cognitive abilities) are observed more readily—if at all—following an acute dose of alcohol [23].
It is known that tolerance can develop early in adolescents and young adults without alcohol use disorder [47, 48]. Considering the scarcity of studies that have evaluated the phenomenon of tolerance in healthy adolescents and the potential vulnerability of females to the neurotoxic effects of alcohol, we performed a study [23] in which we observed that binge drinkers performed better in IVM than refrainers when given alcohol (showing the development of alcohol tolerance) and binge drinkers performed worse than refrainers after consuming a nonalcoholic control drink (as their memory would have been damaged). Thus, adolescent women are more vulnerable to the neurotoxic effects of alcohol than men, because the cognitive tolerance effect of alcohol on IVM develops in BD women but not in BD men. The phenomenon of women beginning to drink earlier and progressing more rapidly than men from drinking onset to problematic drinking, known as the “telescoping effect” [49, 50, 51], would explain why adolescent women develop cognitive tolerance earlier than men.
Although men and women have been included in some of the reviewed studies, only ours [23, 24] were carried out in order to specifically evaluate these gender differences in adolescents. In our second study [24], although the tolerance phenomenon was not evaluated (because refrainers did not consume an acute dose of alcohol), no gender differences were detected in IVM and WM performance with BAC > 0.5 mg/L. We suspect that an increased BAC overrides these cognitive differences between men and women. At the same time, the BAC is dependent on several factors such as rates of absorption, distribution, and elimination, as well as gender, body mass and composition, food effects, and type of alcohol. Therefore, careful extrapolation and interpretation of the BAC is needed [52].
The findings of the present review would be bolstered with a tighter control of factors that contribute to heterogeneity of results, such as:
Not taking into account the gender factor. The inclusion of men and women in study samples is more representative of the population.
Variability in the sample’s history of consumption, which can encompass a wide range (refrainers, habitual consumers/moderate drinkers, light binge drinkers, heavy binge drinkers, etc.).
The use of different tests/batteries for evaluating similar memories (e.g., CANTAB, ImPACT, WAIS-R).
The registration of performance in ascendant/descendant BACs. For example, more deleterious effects are observed in ascendant BAC versus descendant BAC. Most of the studies either they evaluate memory performance in descendant BAC or they do not specify whether the BAC is ascendant or descendant.
Variability in the age ranges in the studies. This variability (see Table 1), without a neat separation between adolescents and young adults, does not allow to properly compare these periods in order to find potential differences. Actually, there are not studies directly evaluating possible differences in the effects of acute BD on memory, comparing adolescents and young adults.
Several studies, using different paradigms (e.g., Stroop task, Go/No-Go task), have also shown that BD during adolescence is associated with poor inhibitory control (e.g., [7, 53]). Inhibitory control processes are developing during adolescence and youth, and a poor inhibitory function may predispose the individual to alcohol misuse [53]. Thus, impaired inhibitory control has been related to increased loss of control over drinking (i.e., a greater number of drinks per episode) [7], and this impairment seems to be related to the severity of alcohol-related problems [54, 55]. Likewise, acute and binge alcohol drinking may impair the inhibitory control and compromise the ability to prevent or stop behavior related to alcohol use. Then, poor inhibitory control can be both the cause and the consequence of excessive alcohol use. Adolescence and young adulthood may be a particularly vulnerable period due to the following reasons: (a) the weak or immature inhibitory functioning typical of this stage may contribute to the inability of the individual to control alcohol use and (b) alcohol consumption per se may alter or interrupt the proper development of inhibitory control leading to a reduced ability to regulate alcohol intake [53]. Therefore, inhibitory control training is a potential effective component of a comprehensive protocol for intervention strategies focused on this at-risk group of young adults who continue a BD trajectory into adulthood. Interventions targeting binge-drinking behavior should aim to inhibitory control training.
Increasing the knowledge about the effects of BD alcohol consumption pattern on memory and other executive functions in adolescents and young adults is also instrumental to designing programs and policy to reduce the impact of drinking in this highly vulnerable population in order to diminish the likelihood of participation in risky behaviors.
After reviewing the literature concerning the effects of one BD episode (with different BACs) on learning and memory performance in adolescents and young adults, the following conclusions can be drawn:
Alcohol BD has differential effects depending on the type of memory. For example, IVM is more sensitive than other memories to the neurotoxic effects of acute doses of alcohol in adolescents and young adults with a BD history (IVM is affected by a moderate BAC, while WM score is undermined only by BAC levels of BD).
BAC is an important factor to take into account when evaluating the acute effects of BD alcohol on memory performance in this type of studies.
Women are more vulnerable to some of the detrimental effects of alcohol than men are. For example, an effect of cognitive alcohol tolerance on IVM has been observed in women but not in men. These gender differences emphasize the need to include females in studies when investigating the neurotoxic effects of alcohol in adolescents and youths.
Further research, particularly longitudinal studies, is necessary in order to confirm the abovementioned findings and to consolidate these conclusions.
In relation to the inhibitory control in binge drinkers, taking into account the scarcity of studies evaluating inhibitory control training on alcohol consumption (e.g., [56, 57, 58]) and the lack of them evaluating this kind of training on BD, future research should investigate long-term implementation of inhibitory control training, emphasizing the importance of this training as part of the intervention strategies focused on this at-risk group.
The authors wish to thank the “Generalitat Valenciana” [PROMETEO-II/2015/020] and the “Universitat de València” [UV-INV_AE18-779336] for the funding part of the work reviewed herein. They also wish to thank Mr. Brian Normanly for his editorial assistance.
The authors have no conflict of interest to declare.
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\\n"}]'},components:[{type:"htmlEditorComponent",content:'Copyright is the term used to describe the rights related to the publication and distribution of original Works. Most importantly from a publisher's perspective, copyright governs how Authors, publishers and the general public can use, publish, and distribute publications.
\n\nIntechOpen only publishes manuscripts for which it has publishing rights. This is governed by a publication agreement between the Author and IntechOpen. This agreement is accepted by the Author when the manuscript is submitted and deals with both the rights of the publisher and Author, as well as any obligations concerning a particular manuscript. However, in accepting this agreement, Authors continue to retain significant rights to use and share their publications.
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