Chapters authored
Role of MicroRNAs in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a common autoimmune disease. The hallmarks of RA are synovial inflammation and hyperplasia, autoantibody production, systemic features, and deformity. A lot of researchers have paid attention to the possibility that microRNAs (miRNAs) play a role in the pathogenesis of RA. miRNAs are a class of small noncoding RNAs, which have 18–25 nucleotides. These small RNAs modify gene expression by binding to target messenger RNA (mRNA), and they block the translation or induce the degradation of target mRNA. Biological relevance of miRNAs has been investigated in physiological and pathological conditions. A growing body of evidence suggests that miRNAs participate in the inflammatory disorders including RA. In this chapter, an overview of biogenesis and function of miRNAs has been presented to introduce researchers to the changes and functional regulation of the key miRNAs in RA and to provide current knowledge in miRNA and RA. It is important to understand the relationship between the key miRNAs and RA pathology as modulation of specific miRNA alterations could be of great pharmaceutical interest in the future.
Part of the book: New Developments in the Pathogenesis of Rheumatoid Arthritis
Role of LncRNA in Rheumatoid Arthritis
Long non-coding RNAs (lncRNAs) are a class of non-coding RNA (ncRNA) molecules that do not have protein coding. They are ubiquitous in the process of transcription and gene regulation. lncRNAs regulation is correlated with many diseases. Rheumatoid arthritis (RA) is a chronic inflammatory disorder and this disease can affect especially joints. Nevertheless, in some patients, RA and inflammation can damage body parts such as the eyes, lungs, skin, heart, and blood vessels. Lots of lncRNAs were confirmed to be correlated with rheumatoid arthritis (RA) pathogenesis. Particularly GAPLINC, ZFAS1, PTGS2, and HOTAIR lncRNAs play a role in RA. This chapter will be explained and summarized the relationship between IncRNAs and RA.
Part of the book: Rheumatoid Arthritis