Born in 1961, Plovdiv, Bulgaria. University education in veterinary medicine in 1986. 13 years experience as a research associate in immunology and diagnostics of infectious zoonotic diseases. Since 2004 - Associate Professor at the Faculty of Biology of Plovdiv University \P. Hilendarski\. Since 2015 - Head of Department \Human anatomy and physioiology\ at Plovdiv University. Married with one daughter.
Dialyzable leukocyte extracts (DLE) are complexes consisting of a large number of low molecular weight substances. These extracts possess immunomodulatory properties, which are mainly attributed to small peptides with molecular weight of 3.5–6.0 kDa called “transfer factor.” This chapter reviews the nature and immunological characteristics of DLE containing transfer factor (TF), their mechanism of action and the possible uses as immunomodulators in human and veterinary medicine. A main advantage of TF-preparations as immunotherapeutic agents is that they induce a rapid immune response against the pathogen (within 24 h) and thereby reduce the time for the patient immune response by 9–13 days. The low level of difficulty of the process of obtaining protocols determines their relatively low cost and the possibility to combine them with other therapeutic agents during treatment makes them subject to medical applications in the future, including against some new diseases.
Part of the book: Immunotherapy