Ali Gamal Al-kaf

Sana'a University

PhD. in pharmaceutical sciences from Russia 2006, Chief Council for Accreditation and Quality Assurance. Previous Dean of Faculty of Pharmacy at Sana\'a University. Professor of Medicinal Chemistry Department. Member of Yemeni Medical Council. Member of many associations and international groups. Executive Editor in Universal Journal of Pharmaceutical Research. Editor and Associate Editor of some international journals. My interest is synthesis and biological activity of 4-oxopyrimidine and quinazolinone -4 derivatives, Structural biology and bioinformatics in drug design, study of Yemeni medicinal plants , development and validation of Spectrophotometric and HPLC methods for different drugs and antibiotics and antimicrobial resistance in Yemen. Author of more than 70 publications, 4 patents and 11 books.

3books edited

3chapters authored

Latest work with IntechOpen by Ali Gamal Al-kaf

One of the problems with modern public health is target searching for new highly effective medicinal preparations. Among those medicinal preparations are the natural and synthetic origins of quinazolinone-4 derivatives. Quinazolinone derivatives are reported to be physiologically and pharmacologically active. They also exhibit a wide range of activities such as anticonvulsant, antiinflammatory, antifungal, antimalarial, and sedative properties. Some of these compounds are identified as drugs used as diuretics, vasodilators, and antihypertensive agents. Moreover, sulfonamide derivatives have been widely used as bacteriostatic agents. Prompted by the above-mentioned facts and in conjunction with our ongoing program on the utility of readily obtainable starting material for the synthesis of heterocyclic systems of biological interest, we have decided to synthesize a series of quinazolinone derivatives having sulfonamide moiety with a potentially wide spectrum of biological responses.

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