Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\n
This achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\n
We are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\n
Thank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"427",leadTitle:null,fullTitle:"Sustainable Energy Harvesting Technologies - Past, Present and Future",title:"Sustainable Energy Harvesting Technologies",subtitle:"Past, Present and Future",reviewType:"peer-reviewed",abstract:"In the early 21st century, research and development of sustainable energy harvesting (EH) technologies have started. Since then, many EH technologies have evolved, advanced and even been successfully developed into hardware prototypes for sustaining the operational lifetime of low?power electronic devices like mobile gadgets, smart wireless sensor networks, etc. Energy harvesting is a technology that harvests freely available renewable energy from the ambient environment to recharge or put used energy back into the energy storage devices without the hassle of disrupting or even discontinuing the normal operation of the specific application. With the prior knowledge and experience developed over a decade ago, progress of sustainable EH technologies research is still intact and ongoing. EH technologies are starting to mature and strong synergies are formulating with dedicate application areas. To move forward, now would be a good time to setup a review and brainstorm session to evaluate the past, investigate and think through the present and understand and plan for the future sustainable energy harvesting technologies.",isbn:null,printIsbn:"978-953-307-438-2",pdfIsbn:"978-953-51-4384-0",doi:"10.5772/945",price:119,priceEur:129,priceUsd:155,slug:"sustainable-energy-harvesting-technologies-past-present-and-future",numberOfPages:270,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"61a870ec0f3bf63739132a7cf4465ca7",bookSignature:"Yen Kheng Tan",publishedDate:"December 22nd 2011",coverURL:"https://cdn.intechopen.com/books/images_new/427.jpg",numberOfDownloads:50578,numberOfWosCitations:123,numberOfCrossrefCitations:84,numberOfCrossrefCitationsByBook:16,numberOfDimensionsCitations:135,numberOfDimensionsCitationsByBook:22,hasAltmetrics:0,numberOfTotalCitations:342,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"February 8th 2011",dateEndSecondStepPublish:"March 8th 2011",dateEndThirdStepPublish:"July 13th 2011",dateEndFourthStepPublish:"August 12th 2011",dateEndFifthStepPublish:"December 10th 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7,8",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"78857",title:"Dr.",name:"Tan Yen",middleName:null,surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng",profilePictureURL:"https://mts.intechopen.com/storage/users/78857/images/system/78857.jpg",biography:"Dr. Tan Yen Kheng is the CEO and co-founder of Printed Power, a high-tech company headquartered in Singapore that develops edge computers for smarter buildings and manufacturing globally (China and the Association of Southeast Asian Nations [ASEAN]). The company empowers customers with sensor-end to application-end platform solutions to discover opportunities and capture value from actionable insights as well as co-create with domain experts using advanced artificial intelligence (AI)/machine learning (ML) tools. Dr. Tan is concurrently the associate editor of the IEEE Sensors Journal and the industrial chair of IEEE Singapore section. He was also chair/professor at the School of Electrical Engineering/Hanergy School of Renewable Energy at Beijing Jiaotong University (BJTU) where he built international partnership programs, delivered seminars and short courses, and performed research exchanges with research staff and students.",institutionString:"Printed Power LTD",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Nanyang Technological University",institutionURL:null,country:{name:"Singapore"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"771",title:"Sustainability Science",slug:"sustainability-science"}],chapters:[{id:"25367",title:"A Modelling Framework for Energy Harvesting Aware Wireless Sensor Networks",doi:"10.5772/26622",slug:"a-modelling-framework-for-energy-harvesting-aware-wireless-sensor-networks",totalDownloads:2445,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Michael R. Hansen, Mikkel Koefoed Jakobsen and Jan Madsen",downloadPdfUrl:"/chapter/pdf-download/25367",previewPdfUrl:"/chapter/pdf-preview/25367",authors:[{id:"67339",title:"MSc.",name:"Mikkel",surname:"Jakobsen",slug:"mikkel-jakobsen",fullName:"Mikkel Jakobsen"},{id:"69921",title:"Prof.",name:"Jan",surname:"Madsen",slug:"jan-madsen",fullName:"Jan Madsen"},{id:"69926",title:"Prof.",name:"Michael",surname:"Hansen",slug:"michael-hansen",fullName:"Michael Hansen"}],corrections:null},{id:"25368",title:"Vibration Energy Harvesting: Machinery Vibration, Human Movement and Flow Induced Vibration",doi:"10.5772/25731",slug:"vibration-energy-harvesting-machinery-vibration-human-movement-and-flow-induced-vibration",totalDownloads:7918,totalCrossrefCites:17,totalDimensionsCites:28,hasAltmetrics:0,abstract:null,signatures:"Dibin Zhu",downloadPdfUrl:"/chapter/pdf-download/25368",previewPdfUrl:"/chapter/pdf-preview/25368",authors:[{id:"64354",title:"Dr.",name:"Dibin",surname:"Zhu",slug:"dibin-zhu",fullName:"Dibin Zhu"}],corrections:null},{id:"25369",title:"Modelling Theory and Applications of the Electromagnetic Vibrational Generator",doi:"10.5772/27236",slug:"modelling-theory-and-applications-of-the-electromagnetic-vibrational-generator",totalDownloads:4043,totalCrossrefCites:1,totalDimensionsCites:10,hasAltmetrics:0,abstract:null,signatures:"Chitta Ranjan Saha",downloadPdfUrl:"/chapter/pdf-download/25369",previewPdfUrl:"/chapter/pdf-preview/25369",authors:[{id:"69384",title:"Dr.",name:"Chitta",surname:"Saha",slug:"chitta-saha",fullName:"Chitta Saha"}],corrections:null},{id:"25370",title:"Modeling and Simulation of Thermoelectric Energy Harvesting Processes",doi:"10.5772/28530",slug:"modeling-and-simulation-of-thermoelectric-energy-harvesting-processes",totalDownloads:9447,totalCrossrefCites:19,totalDimensionsCites:26,hasAltmetrics:0,abstract:null,signatures:"Piotr Dziurdzia",downloadPdfUrl:"/chapter/pdf-download/25370",previewPdfUrl:"/chapter/pdf-preview/25370",authors:[{id:"74230",title:"Dr.",name:"Piotr",surname:"Dziurdzia",slug:"piotr-dziurdzia",fullName:"Piotr Dziurdzia"}],corrections:null},{id:"25371",title:"WSN Design for Unlimited Lifetime",doi:"10.5772/26925",slug:"wsn-design-for-unlimited-lifetime",totalDownloads:2822,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:null,signatures:"Emanuele Lattanzi and Alessandro Bogliolo",downloadPdfUrl:"/chapter/pdf-download/25371",previewPdfUrl:"/chapter/pdf-preview/25371",authors:[{id:"68291",title:"Prof.",name:"Alessandro",surname:"Bogliolo",slug:"alessandro-bogliolo",fullName:"Alessandro Bogliolo"},{id:"68300",title:"Dr.",name:"Emanuele",surname:"Lattanzi",slug:"emanuele-lattanzi",fullName:"Emanuele Lattanzi"}],corrections:null},{id:"25372",title:"Wearable Energy Harvesting System for Powering Wireless Devices",doi:"10.5772/39055",slug:"wearable-energy-harvesting-system-for-powering-wireless-devices",totalDownloads:4048,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Yen Kheng Tan and Wee Song Koh",downloadPdfUrl:"/chapter/pdf-download/25372",previewPdfUrl:"/chapter/pdf-preview/25372",authors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],corrections:null},{id:"25373",title:"Vibration Energy Harvesting: Linear and Nonlinear Oscillator Approaches",doi:"10.5772/25623",slug:"vibration-energy-harvesting-linear-and-nonlinear-oscillator-approaches",totalDownloads:5250,totalCrossrefCites:7,totalDimensionsCites:17,hasAltmetrics:0,abstract:null,signatures:"Luca Gammaitoni, Helios Vocca, Igor Neri, Flavio Travasso and Francesco Orfei",downloadPdfUrl:"/chapter/pdf-download/25373",previewPdfUrl:"/chapter/pdf-preview/25373",authors:[{id:"63935",title:"Prof.",name:"Luca",surname:"Gammaitoni",slug:"luca-gammaitoni",fullName:"Luca Gammaitoni"}],corrections:null},{id:"25374",title:"Energy Harvesting Technologies: Thick-Film Piezoelectric Microgenerator",doi:"10.5772/25547",slug:"energy-harvesting-technologies-thick-film-piezoelectric-microgenerator",totalDownloads:5642,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Swee Leong Kok",downloadPdfUrl:"/chapter/pdf-download/25374",previewPdfUrl:"/chapter/pdf-preview/25374",authors:[{id:"63664",title:"Dr.",name:"Swee Leong",surname:"Kok",slug:"swee-leong-kok",fullName:"Swee Leong Kok"}],corrections:null},{id:"25375",title:"Hydrogen from Stormy Oceans",doi:"10.5772/27215",slug:"hydrogen-from-stormy-oceans",totalDownloads:2653,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Helmut Tributsch",downloadPdfUrl:"/chapter/pdf-download/25375",previewPdfUrl:"/chapter/pdf-preview/25375",authors:[{id:"69270",title:"Dr.",name:null,surname:"Tributsch",slug:"tributsch",fullName:"Tributsch"}],corrections:null},{id:"25376",title:"Design Issues in Radio Frequency Energy Harvesting System",doi:"10.5772/25348",slug:"design-issues-in-radio-frequency-energy-harvesting-system",totalDownloads:6313,totalCrossrefCites:38,totalDimensionsCites:50,hasAltmetrics:0,abstract:null,signatures:"Chomora Mikeka and Hiroyuki Arai",downloadPdfUrl:"/chapter/pdf-download/25376",previewPdfUrl:"/chapter/pdf-preview/25376",authors:[{id:"63050",title:"Dr.",name:"Chomora",surname:"Mikeka",slug:"chomora-mikeka",fullName:"Chomora Mikeka"},{id:"69313",title:"Prof.",name:"Hiroyuki",surname:"Arai",slug:"hiroyuki-arai",fullName:"Hiroyuki Arai"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"135",title:"Wireless Sensor Networks",subtitle:"Application - Centric Design",isOpenForSubmission:!1,hash:null,slug:"wireless-sensor-networks-application-centric-design",bookSignature:"Geoff V Merrett and Yen Kheng Tan",coverURL:"https://cdn.intechopen.com/books/images_new/135.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"137",title:"Sustainable Wireless Sensor Networks",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"sustainable-wireless-sensor-networks",bookSignature:"Winston Seah and Yen Kheng Tan",coverURL:"https://cdn.intechopen.com/books/images_new/137.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"136",title:"Smart Wireless Sensor Networks",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"smart-wireless-sensor-networks",bookSignature:"Hoang Duc Chinh and Yen Kheng Tan",coverURL:"https://cdn.intechopen.com/books/images_new/136.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4576",title:"Rehabilitation Engineering",subtitle:null,isOpenForSubmission:!1,hash:"8c4fcda89f1173a1ec31aabd7f4ac894",slug:"rehabilitation-engineering",bookSignature:"Tan Yen Kheng",coverURL:"https://cdn.intechopen.com/books/images_new/4576.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10150",title:"Smart Manufacturing",subtitle:"When Artificial Intelligence Meets the Internet of Things",isOpenForSubmission:!1,hash:"87004a19de13702d042f8ff96d454698",slug:"smart-manufacturing-when-artificial-intelligence-meets-the-internet-of-things",bookSignature:"Tan Yen Kheng",coverURL:"https://cdn.intechopen.com/books/images_new/10150.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"205",title:"Fundamental and Advanced Topics in Wind Power",subtitle:null,isOpenForSubmission:!1,hash:"b8b5955addb75d98a6bba1c94e3e7a74",slug:"fundamental-and-advanced-topics-in-wind-power",bookSignature:"Rupp Carriveau",coverURL:"https://cdn.intechopen.com/books/images_new/205.jpg",editedByType:"Edited by",editors:[{id:"22234",title:"Dr.",name:"Rupp",surname:"Carriveau",slug:"rupp-carriveau",fullName:"Rupp Carriveau"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2706",title:"Small-Scale Energy Harvesting",subtitle:null,isOpenForSubmission:!1,hash:"63bc4c27bdf9ec1e00aa20ff6f1d804f",slug:"small-scale-energy-harvesting",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/2706.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"115",title:"Wind Turbines",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"wind-turbines",bookSignature:"Ibrahim Al-Bahadly",coverURL:"https://cdn.intechopen.com/books/images_new/115.jpg",editedByType:"Edited by",editors:[{id:"19588",title:"Dr.",name:"Ibrahim H.",surname:"Al-Bahadly",slug:"ibrahim-h.-al-bahadly",fullName:"Ibrahim H. Al-Bahadly"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"13",title:"Paths to Sustainable Energy",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"paths-to-sustainable-energy",bookSignature:"Jatin Nathwani and Artie Ng",coverURL:"https://cdn.intechopen.com/books/images_new/13.jpg",editedByType:"Edited by",editors:[{id:"13730",title:"Dr.",name:"Artie",surname:"Ng",slug:"artie-ng",fullName:"Artie Ng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"212",title:"Energy Storage in the Emerging Era of Smart Grids",subtitle:null,isOpenForSubmission:!1,hash:"8cd6021285906516c727802d02ce0954",slug:"energy-storage-in-the-emerging-era-of-smart-grids",bookSignature:"Rosario Carbone",coverURL:"https://cdn.intechopen.com/books/images_new/212.jpg",editedByType:"Edited by",editors:[{id:"11592",title:"Prof.",name:"Rosario",surname:"Carbone",slug:"rosario-carbone",fullName:"Rosario Carbone"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"erratum-metallothioneins-saccharomyces-cerevisiae-and-heavy-metals-a-biotechnology-triad-",title:"Erratum - Metallothioneins, Saccharomyces cerevisiae, and Heavy Metals: A Biotechnology Triad?",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/60025.pdf",downloadPdfUrl:"/chapter/pdf-download/60025",previewPdfUrl:"/chapter/pdf-preview/60025",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/60025",risUrl:"/chapter/ris/60025",chapter:{id:"56597",slug:"metallothioneins-saccharomyces-cerevisiae-and-heavy-metals-a-biotechnology-triad-",signatures:"Ileana Cornelia Farcasanu and Lavinia Liliana Ruta",dateSubmitted:"December 11th 2016",dateReviewed:"July 7th 2017",datePrePublished:null,datePublished:"December 13th 2017",book:{id:"6007",title:"Old Yeasts",subtitle:"New Questions",fullTitle:"Old Yeasts - New Questions",slug:"old-yeasts-new-questions",publishedDate:"December 13th 2017",bookSignature:"Candida Lucas and Celia Pais",coverURL:"https://cdn.intechopen.com/books/images_new/6007.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"95655",title:"Prof.",name:"Cândida",middleName:null,surname:"Lucas",slug:"candida-lucas",fullName:"Cândida Lucas"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"203734",title:"Dr.",name:"Ileana",middleName:"Cornelia",surname:"Farcasanu",fullName:"Ileana Farcasanu",slug:"ileana-farcasanu",email:"ileana.farcasanu@chimie.unibuc.ro",position:null,institution:{name:"University of Bucharest",institutionURL:null,country:{name:"Romania"}}},{id:"203865",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ruta",fullName:"Lavinia Ruta",slug:"lavinia-ruta",email:"lavinia.ruta@chimie.unibuc.ro",position:null,institution:{name:"University of Bucharest",institutionURL:null,country:{name:"Romania"}}}]}},chapter:{id:"56597",slug:"metallothioneins-saccharomyces-cerevisiae-and-heavy-metals-a-biotechnology-triad-",signatures:"Ileana Cornelia Farcasanu and Lavinia Liliana Ruta",dateSubmitted:"December 11th 2016",dateReviewed:"July 7th 2017",datePrePublished:null,datePublished:"December 13th 2017",book:{id:"6007",title:"Old Yeasts",subtitle:"New Questions",fullTitle:"Old Yeasts - New Questions",slug:"old-yeasts-new-questions",publishedDate:"December 13th 2017",bookSignature:"Candida Lucas and Celia Pais",coverURL:"https://cdn.intechopen.com/books/images_new/6007.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"95655",title:"Prof.",name:"Cândida",middleName:null,surname:"Lucas",slug:"candida-lucas",fullName:"Cândida Lucas"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"203734",title:"Dr.",name:"Ileana",middleName:"Cornelia",surname:"Farcasanu",fullName:"Ileana Farcasanu",slug:"ileana-farcasanu",email:"ileana.farcasanu@chimie.unibuc.ro",position:null,institution:{name:"University of Bucharest",institutionURL:null,country:{name:"Romania"}}},{id:"203865",title:"Dr.",name:"Lavinia",middleName:null,surname:"Ruta",fullName:"Lavinia Ruta",slug:"lavinia-ruta",email:"lavinia.ruta@chimie.unibuc.ro",position:null,institution:{name:"University of Bucharest",institutionURL:null,country:{name:"Romania"}}}]},book:{id:"6007",title:"Old Yeasts",subtitle:"New Questions",fullTitle:"Old Yeasts - New Questions",slug:"old-yeasts-new-questions",publishedDate:"December 13th 2017",bookSignature:"Candida Lucas and Celia Pais",coverURL:"https://cdn.intechopen.com/books/images_new/6007.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"95655",title:"Prof.",name:"Cândida",middleName:null,surname:"Lucas",slug:"candida-lucas",fullName:"Cândida Lucas"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"7757",leadTitle:null,title:"Sources of High-Energy Radiation",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tHigh energy radiation has been widely studied in a broad range of applications in life science and industry. It has also been an important tool in numerous research fields. The aim of this book is to provide the reader with an overview of the sources of high energy radiation, their productions and applications. It will feature comprehensive reviews on popular techniques in research and applications and focus on the latest developments in each field. The topics of the book will cover production of high energy radiation including gamma rays, x-rays and high energy particles using accelerators or nuclear reactions, applications of high energy radiation in materials science, nuclear science as well as medicine, life science and industry. The book intends to present the latest developments and the current state-of-the art in production, instrumentation and applications of gamma rays, high energy x-rays, ion beams and neutrons. It will hopefully be of interest to novices and experts in the area of high energy radiation as it will address the real obstacles to state of the art applications, and should help define future research directions.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"e50d376fd4279b09efabe761cb7155a0",bookSignature:"Prof. Farida Selim",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/7757.jpg",keywords:"Accelerators, Synchroton radiation, X-ray analysis by Synchrotron radiation, Proton induced x-ray, Gamma induced positron spectroscopy, Accelerator based positron beams, Interaction of ion beam with matter, Neutron diffraction, Radiation damage, Neutron induced defects, Linear and pulsed accelerators, Applications of accelerators in medicine",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 3rd 2019",dateEndSecondStepPublish:"October 24th 2019",dateEndThirdStepPublish:"December 23rd 2019",dateEndFourthStepPublish:"March 12th 2020",dateEndFifthStepPublish:"May 11th 2020",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"185781",title:"Prof.",name:"Farida",middleName:null,surname:"Selim",slug:"farida-selim",fullName:"Farida Selim",profilePictureURL:"https://mts.intechopen.com/storage/users/185781/images/system/185781.jpeg",biography:"Farida Selim has a broad research program in the fields of radiation and materials. Her research covers a wide range of topics from developing new techniques and instrumentation, material growth and characterization to defect studies. \r\n\r\nShe is an expert on positron annihilation and luminescence spectroscopies and has been very active in using accelerators in materials science, and developing new techniques.\r\n\r\nSelim has earned international recognition in a number of scientific communities that has been reflected in selecting her to be a member of the International Scientific Committee of Positron and Positronium Chemistry (PPC), a member of the International Advisory Committee on Positron Studies of Defects (PSD), and a member of the International Advisory Committee of the International Conference on Positron Annihilation (ICPA). She has been also a Secretary of the International Academic Advisory Committee on 'Persistent and Photostimulable Phosphors” in 2015. She was the organizer and chair of the largest positron conference ICPA- 18 in August 2018 and she has been selected to host and chair the International Workshop on ZnO and other oxide semiconductors in September 2020.\r\n\r\nSelim is an editor of a scientific book, author of a number of peer reviewed journal articles and three book chapters and sole inventor of 5 patents, 2 issued and 3 pending, in addition to her significant invention at the beginning of her career Accelerator-based positron annihilation spectroscopy” technique which extends positron annihilation spectroscopy to numerous new fields in materials science. The technique is known today as Gamma induced positron spectroscopy (GIPS); it has been recently adopted to build a unique materials research facility at the superconducting accelerator facility in Dresden, Germany and similar facilities in Japan and India.",institutionString:"Bowling Green State University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Bowling Green State University",institutionURL:null,country:{name:"United States of America"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"20",title:"Physics",slug:"physics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"301331",firstName:"Mia",lastName:"Vulovic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/301331/images/8498_n.jpg",email:"mia.v@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"8356",title:"Metastable, Spintronics Materials and Mechanics of Deformable Bodies",subtitle:"Recent Progress",isOpenForSubmission:!1,hash:"1550f1986ce9bcc0db87d407a8b47078",slug:"solid-state-physics-metastable-spintronics-materials-and-mechanics-of-deformable-bodies-recent-progress",bookSignature:"Subbarayan Sivasankaran, Pramoda Kumar Nayak and Ezgi Günay",coverURL:"https://cdn.intechopen.com/books/images_new/8356.jpg",editedByType:"Edited by",editors:[{id:"190989",title:"Dr.",name:"Subbarayan",surname:"Sivasankaran",slug:"subbarayan-sivasankaran",fullName:"Subbarayan Sivasankaran"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"68165",title:"Amaranth: An Ancient and High-Quality Wholesome Crop",doi:"10.5772/intechopen.88093",slug:"amaranth-an-ancient-and-high-quality-wholesome-crop",body:'
1. Introduction
1.1 Amaranthus sp. taxonomy and distribution
Amaranthus L. is a eudicot genus in the Amaranthaceae family of the order Caryophyllales and is commonly known as the pigweeds or amaranths. The genus comprises about 75 species, which are generally annuals, and are distributed throughout the world’s temperate and tropical regions [1, 2]. The genus Amaranthus is further divided into three subgenera, Acnida, Albersia, and Amaranthus [3], with Acnida being dioecious and subgenera Albersia and Amaranthus being monoecious but with distinctive floral morphology. The three main domesticated species of Amaranthus (Amaranthus caudatus L., A. cruentus L., and A. hypochondriacus L.) originated in the Americas and are primarily cultivated for grain, as potherbs and ornamentals [2, 4].
Amaranth is an ancient crop in which scientific and commercial interest has recently been renewed. The grain amaranths (A. hypochondriacus, A. caudatus, A. cruentus) have many favorable agronomic properties and are highly adaptable to various ecological zones, with better resistance to biotic and abiotic stresses than many conventional other food crops [2]. These species also have advantages of being protein-rich C4 pseudo-cereals that can be adapted to cultivation in a wide range of environments, with good tolerance of drought and salinity [2, 5]. Amaranths also exhibit superior water use efficiency compared to many other C3 and C4 crops [6].
1.2 Amaranth use in the ancient times
The grain amaranth was an important crop for the Aztecs and the Incas [1, 2]. In the pre-Columbian period, it was one of the major crops like beans and corn in the New World and carried religious importance [1]. During the various dates of the religious calendar, Aztec people ground amaranth seeds mixed with honey or human blood and make different shapes of animals, birds, mountains, and gods, and they were eaten during the ceremonies [1, 2].
Prior to the conquest by Spaniards, Mexicans had a culture where a ceremonial paste called Zoale was prepared from amaranth grains and was fed to the slaves before they were sacrificed to the gods [1, 7]. From the Christian viewpoint, the use of grain amaranth was the very symbol of heathen idolatry [1], and therefore Spaniards discouraged the cultivation of Amaranthus [1, 7]. Although the cultivation was highly suppressed by the Spanish conquistadors, small patches of A. hypochondriacus were still grown inside maize fields [1, 2].
Along with the widespread use in food products, grain amaranths also gained religious significance in India and Nepal. In Uttar Pradesh, India, the crop amaranth is recognized as Ramdana (seed given by Lord Ram) [7]. In the states of Madhya Pradesh and Gujarat, India, amaranth is recognized as Rajgira (Rajgira, a seed given by King, an incarnation of Lord Vishnu). In Hindu culture, popped amaranth grain is soaked in milk and is one of the food items permitted to be eaten during religious festivals after a long fasting [2, 7]. In different parts of Nepal, India, and Pakistan, popped amaranth seed is used to make laddoos and confections like alegria in Mexico. Laddoos carries an important religious significance. It is considered a pure food and can be offered to Hindu gods. Around the Nilgiri Hills in India, Badagas peoples have a ritual that they offer a basket of puffed amaranths on Badagas funeral pyre [7, 8]. Looking at those cultural instances, grain amaranths may have been migrated from the Americas to the Old World only about 500 years ago; but it is quite astonishing to get strong evidences on the connection of amaranth grain to Hindu culture in the Old World.
2. Nutritional facts of amaranths
2.1 Amaranth proteins
Based on the solubility and extractability, there are four major seed storage proteins in plants: albumins, globulins, prolamins, and glutelins. In pseudo-cereals, including amaranth, the major seed storage proteins are composed of albumin, globulin, and glutelin [9, 10, 11, 12, 13]. However, there are some reports showing traces of prolamins in some of the amaranth species [10, 12]. Storage proteins accumulate in developing seeds and store nitrogen, carbon, and sulfur [14]. These proteins are hydrolyzed and mobilized during seed germination and early seedling growth [14, 15]. They do not carry any enzymatic functions and are found only in seeds. However, some storage proteins may also be involved in defense or metabolism. These proteins are synthesized in the rough endoplasmic reticulum. As seeds mature, they are collected in the protein bodies that are derived from vacuole [15]. They may also act as a sink for excess nitrogen.
Chief distinction between the major proteins is outlined as follows: albumin storage proteins are water soluble with low molecular weight 10–18 kDa and low isoelectric point between pH 4.0 and 5.0 [16]. Based on the sedimentation coefficients (S20w), albumin has the coefficient of approximately 2S; therefore it is defined as 2S albumin [17]. However, in the case of pseudo-cereals, the sedimentation coefficients of 1.7S comprised of polypeptides with Mr. ranging from 4000 to 20,000, and they are high in sulfur-containing amino acids, including cysteine and methionine [17]. Majority of albumins consists of two polypeptide chains linked by four disulfide bonds [18]. They are found in dicot plants and account for 20–60% of the total proteins in seed [16]. Globulin storage proteins are soluble in salt with their molecular weights in the range of 150–190 kDa [16]. They have an isoelectric point of pH 5–10 [19]. Based on the sedimentation coefficients, (S20w), globulin has the coefficients ranging from 7S to 12S [16]. They lack cysteine residues and lack disulfide bonds [16]. Glutelin storage proteins are soluble in borate buffer but poorly soluble in water. They have molecular weights in the range of 45–150 kDa and an isoelectric point range between the pH range of 4.8 and 8.7 and are highly hydrophobic in nature [16]. They are high in proline and glutamine content [16]. One of the distinctive signal peptides that is distinguished from other storage proteins is the 37 amino acid sequence at the NH2 terminus that is followed by 269 amino acid acidic subunit (Mr = 32,489) and a 193 amino acid basic unit (Mr = 19,587) [20].
2.2 Lysine content
Amaranth grain and leaves are popular for their nutritional value. Protein content is about 15% in grains [21], and it has a well-balanced amino acid composition with high lysine content [22]. Lysine is the limiting amino acid in most of the cereal crops including wheat, sorghum, and rice, but it is abundant in amaranth; only the first limiting amino acid in amaranth is leucine [21], and it is also abundant in most of our staple food sources. Therefore, amaranth is considered as a complete protein supplier when it is consumed with another cereal.
2.3 Seed properties and nutrient content
Grain amaranth plant produces millions of seeds that are small (≈1 mm) in diameter and has not been analyzed for detailed morphological features [23, 24]. The color of the seeds is highly variable from white, gold, brown, and pink to black [24]. Coons [25] reported that black color is dominant over white and a single gene controls the inheritance. It is possible that the seed coat colors, perisperm type, and seed shape in Amaranthus species are controlled by different gene loci. Seed shape changes based on angle of view; in lateral view seeds appear lenticular in shape, and in front view seeds appear circular or obovate [23]. Adhikary [24] reported white-vitreous and white-opaque type of seeds. Although seed shape and size may not have a significant impact in the nutrient content of a seed, some pigmented seeds have been reported to contain different amounts of nutrient components. For instance, [21] reported that pale-colored seeds of A. caudatus contain about 14% of protein, 10% of fat, 64% of starch, and 8% of dietary fiber, while black-pigmented seeds were reported to contain 16% of dietary fiber, with lysine concentration ranged between 5.2 and 6.0 g/16 g N in the grains [21]. Moreover, protein digestibility was found to be higher in pale seeds than in the black seeds [21].
Starch is formed by two glucan polymers, amylose and amylopectin [26], and is stored in the perisperm of amaranth seed [27]. Like the grasses, amaranth starch can be classified as either glutinous (waxy) or non-glutinous (starchy) [27]. Non-glutinous (starchy) seeds contain both amylose and amylopectin, and glutinous (waxy) seeds lack amylose [24, 26]. Both perisperm forms are found in all three species of the grain Amaranthus [26]. Amaranth seeds contain 65–75% of starch [28], and the digestibility of cooked amaranth seeds resulted in a similar response to white bread; however, flaked and roasted seeds responded with a slightly increased glycemic response [29, 29].
2.4 Squalene content
Squalene is a unique triterpene compound that has a biological and pharmacological importance. Although squalene is an intermediate product in the cholesterol biosynthesis process [30], earlier work has predicted that daily consumption can decrease cholesterol levels [31]. It can inhibit chemically induced breast and colon cancer [32]. There are also evidences of a lower frequency of heart diseases in the Mediterranean region [33], as people in this region consume more olive oil, which is rich in squalene [34]; thus it is believed that squalene consumption in the diet has a positive impact on human health. It originates partly from cholesterol synthesis process and partly from dietary sources such as plant oils or shark liver. Among the different types of plant oils, oil extracted from olive and amaranth has a higher concentration of squalene [34, 35]. Especially, grain amaranths have been suggested as an alternative natural source of squalene. The chemical content in five different accessions of A. cruentus was reported in the range of 2.26–5.67% [36]. Furthermore, in other domesticated species, [37] reported 3.6% in A. hypochondriacus and 6.1% in A. tricolor.
2.5 Gluten-free grain
Amaranthus is a gluten-free grain [38], and hence it is a suitable diet for a person with celiac disease (CD) [39, 40]. CD is an autoimmune condition or inflammatory disease, which affects the small intestine triggered by the gluten protein [41, 42] and can lead to weight loss, fatigue, malabsorption, abdominal pain, vomiting, and diarrhea [43]. The main sources of gluten protein are wheat, barley, and rye [42]. CD patients must follow a strict gluten-free diet, and this can potentially lead to nutrient deficiency [43]. Generally, gluten-free products are made with refined flours and starch and require specific packaging material and frequent use of chemical preservatives [44, 45]. This makes a challenge for both producer and consumer. One of the biggest challenges for food technologist is to enrich the nutritional value of gluten-free products with balanced dietary fibers and proteins [44, 46]. Hence, amaranths can be an alternative to address the challenge. In fact, amaranth has become one of the greatest supplements in gluten-free food commodities to enhance nutritional values [47]. Amaranth contains similar macronutrients as wheat and 2–3 times higher than other gluten free crops [42]. Seed protein of amaranth is greater than cereals and legumes [22]. Besides, amaranth has higher lysine and starch than in other cereals [40]. Monosaccharide composition of dietary fiber present in amaranth is well known [48, 24], and amaranth could serve as a significant source of dietary fiber [48]. Moreover, amaranth has higher fiber and mineral content than other gluten-free grains [21]. In today’s context, amaranth is one of the few gluten-free pseudo-cereals that has been used in a wide variety of gluten-free food commodities. Amaranth is usually combined with other gluten-free cereals such as rice, corn, and cassava in a variety of food products. For example, blending of amaranth with other flours such as cassava [46] and rice [47] in pasta formulation and rice and maize in bakery items [49, 42] has been introduced to enhance the nutritional value of the pasta and bakery items [46]. Because of its higher nutritional profile, genetic diversity, and high adaptability, amaranth can be considered as an excellent supplement to produce gluten-free food products.
One of the most common and costly problems affecting bakery products is fungal contamination. Rizzello et al. [45] reported that the use of amaranth in bakery products can enhance antifungal activity in bread. Amaranth seeds contain some antifungal peptides, which can show a defensive response toward pathogenic fungi [50]. It is noteworthy to mention that amaranth is rich in betalain pigment, which has also been shown to exhibit antimicrobial activities. Thus, betalain is a high demand in the food coloring industry. These pigments with a strong hue not only color the food products but also provide strong antimicrobial response. Thus, amaranth can be an excellent natural additive in the food industry.
2.6 Antioxidant properties of amaranth
To date, 75 different betalains have been reported from 17 of the 34 families in the Caryophyllales order [51]. Interestingly, no species outside Caryophyllales has been found to produce betalains naturally [52]. Most species in the Amaranthaceae have detectable betalains in organs including root, stem, leaves, and flowers. The ecological functions of betalains are presumed to include attracting pollinators to flowers and possibly protect vegetative cells from stresses. There is a long-standing speculation that these pigments are involved in response to abiotic and biotic stresses, but evidence in support of this idea is scant.
Red beetroot (B. vulgaris) is the only commercial betalain source [52], although amaranths have also been proposed as commercial sources of betalains [53, 54]. These betalains have some limited use in food coloring and also have several reported health benefits [55]. Chemical and biological experiments have demonstrated the antioxidant capacity of betalains [56]. Cai et al. [53] showed that the betalains from Amaranthaceae were stronger antioxidants than ascorbic acid, rutin, and catechins. Betalains have also been reported to have anticancer properties [57]. As these chemicals scavenge free radicals, it is expected that they may help prevent cancer and cardiovascular disease [55]. Sreekanth et al. [58] showed that betalain induces dose- and time-dependent cell deaths of the human chronic myeloid leukemia cell line (K562). Moreover, betalain extract from A. spinosus has a significant antimalarial activity in mice [59]. Pigment extract from beetroot pomace also inhibited the growth of gram-negative bacteria [59, 60] and induced zones of reduced growth in Salmonella typhimurium and Bacillus cereus [61]. Thus, amaranth plant is enriched with both nutritional and nutraceutical properties and is a wholesome crop for the future generation.
3. Concluding remarks
Amaranth was a staple of the Aztec diet and is described now as a “superfood” in part because of its high protein content and balanced amino acid profile. It produces a large number of seeds loaded with high-quality protein components, squalene, lysine, and many other health benefitting nutritional and nutraceutical components. Amaranth grain is gluten-free, which makes it a desirable food crop for millions of peoples all over the world. This widely distributed and protein-rich pseudo-cereal has a potential to support food security. However, this crop is still not in the mainstream cultivation practices in North America and in many parts of the world. With the increasing understanding of molecular and biological information of this crop, there is a strong basis for amaranth to be considered for our future generation. As we are witnessing the massive increase in human population in the next few decades and global climate change, we strongly believe amaranth has a huge potential to support the global food system.
Conflict of interest
All authors have read and approved the manuscript for submission. There is no competing interest.
\n',keywords:"amaranth, lysine, complete protein, gluten-free, ancient crop",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/68165.pdf",chapterXML:"https://mts.intechopen.com/source/xml/68165.xml",downloadPdfUrl:"/chapter/pdf-download/68165",previewPdfUrl:"/chapter/pdf-preview/68165",totalDownloads:700,totalViews:0,totalCrossrefCites:4,totalDimensionsCites:6,totalAltmetricsMentions:0,introChapter:null,impactScore:2,impactScorePercentile:79,impactScoreQuartile:4,hasAltmetrics:0,dateSubmitted:"March 28th 2019",dateReviewed:"June 17th 2019",datePrePublished:"January 7th 2020",datePublished:"March 18th 2020",dateFinished:"July 17th 2019",readingETA:"0",abstract:"Amaranth was a staple of the Aztec diet and is described as a “superfood” in part because of its high protein content and well-balanced amino acid profile. In terms of nutrient content, amaranth surpasses many staple crops such as rice, corn, and wheat. Additionally, lysine content is twice as much than in rice and thrice as much than in corn. Along with desirable agronomic traits, this crop has been hugely applauded for its gluten-free nature. Not only can it benefit vegan and gluten allergy personals, but it also has the potential to supply high-quality proteins and at the same time provides antimicrobial activities in the packaged food items. Despite all of these properties, this crop is still not in the mainstream cultivation practices in North America and in many parts of the world. As the planet is expecting massive increase in human population and global climate change, we firmly believe that this widely distributed, ancient, protein-rich pseudo-cereal has a potential to augment our food system. In this book chapter, we aim to report the nutritional properties of grain amaranth.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/68165",risUrl:"/chapter/ris/68165",book:{id:"8949",slug:"nutritional-value-of-amaranth"},signatures:"Dinesh Adhikary, Upama Khatri-Chhetri and Jan Slaski",authors:[{id:"299993",title:"Dr.",name:"Dinesh",middleName:null,surname:"Adhikary",fullName:"Dinesh Adhikary",slug:"dinesh-adhikary",email:"dinesh.adhikary@ubc.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}},{id:"300684",title:"Ms.",name:"Upama",middleName:null,surname:"Khatri-Chhetri",fullName:"Upama Khatri-Chhetri",slug:"upama-khatri-chhetri",email:"upama@ualberta.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"University of Alberta",institutionURL:null,country:{name:"Canada"}}},{id:"308380",title:"Dr.",name:"Jan",middleName:null,surname:"Slaski",fullName:"Jan Slaski",slug:"jan-slaski",email:"Jan.Slaski@innotechalberta.ca",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Amaranthus sp. taxonomy and distribution",level:"2"},{id:"sec_2_2",title:"1.2 Amaranth use in the ancient times",level:"2"},{id:"sec_4",title:"2. Nutritional facts of amaranths",level:"1"},{id:"sec_4_2",title:"2.1 Amaranth proteins",level:"2"},{id:"sec_5_2",title:"2.2 Lysine content",level:"2"},{id:"sec_6_2",title:"2.3 Seed properties and nutrient content",level:"2"},{id:"sec_7_2",title:"2.4 Squalene content",level:"2"},{id:"sec_8_2",title:"2.5 Gluten-free grain",level:"2"},{id:"sec_9_2",title:"2.6 Antioxidant properties of amaranth",level:"2"},{id:"sec_11",title:"3. Concluding remarks",level:"1"},{id:"sec_15",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Sauer JD. The grain amaranths: A survey of their history and classification. Annals of the Missouri Botanical Garden. 1950;37:561-632'},{id:"B2",body:'Sauer JD. Revision of the dioecious amaranths. Madrono. 1955;13:5-46'},{id:"B3",body:'Mosyakin SL, Robertson KR. New infragenic taxa, and combinations in Amaranthus (Amaranthaceae). Annales Botanici Fennici. 1996;33:275-281'},{id:"B4",body:'Fritz GJ. New dates and data on early agriculture: The legacy of complex hunter-gatherers. Annals of the Missouri Botanical Garden. 1995;82:3-15'},{id:"B5",body:'Teng XL, Chen N, Xiao XG. Identification of a catalase-phenol oxidase in betalain biosynthesis in red Amaranth (Amaranthus cruentus). Frontiers in Plant Science. 2015;6:1228'},{id:"B6",body:'Huerta-ocampo JA, Barrera-pacheco A, Mendoza-herna CS, Espitia-rangel E, Mock H, Barba AP. Salt stress-induced alterations in the root proteome of Amaranthus cruentus L. Journal of Proteome Research. 2014;13:3607-3627'},{id:"B7",body:'Sauer JD. The grain amaranths and their relatives: A revised taxonomic and geographic survey. Annals of the Missouri Botanical Garden. 1967;54:103'},{id:"B8",body:'Noble AW, Nobel BL. Badaga funeral customs. Anthropos. 1965;60:262-272'},{id:"B9",body:'Konishi Y, Fumita Y, Ikeda K, Okuno K, Fuwa H. Isolation and characterization of globulin from seeds of Amaranthus hypochondriacus L. Agricultural and Biological Chemistry. 1965;49:1453-1459'},{id:"B10",body:'Gorinstein S, Moshe R, Greene LJ, Paulo A. Evaluation of four Amaranthus species through protein electrophoretic patterns and their amino acid composition. Journal of Agricultural and Food Chemistry. 1991;39:851-854'},{id:"B11",body:'Barba de la Rosa AP, Gueguen J, Paredos-Lopez O, Viroben G. Fractionation procedures, electrophoretic characterization, and amino acid composition of amaranth seed proteins. Journal of Agricultural and Food Chemistry. 1992;40:931-936'},{id:"B12",body:'Leyva-Lopez NE, Vasco N, Barba de la Rosa AP, Paredes-Lopez O. Amaranth seed proteins: Effect of defatting on extraction yield and on electrophoretic patterns. Plant Foods for Human Nutrition. 1995;47:49-53'},{id:"B13",body:'Shewry PR, Pandya MJ. The 2S albumin storage proteins. In: Shewry PR, Casey R, editors. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1999. pp. 563-586'},{id:"B14",body:'Fujiwara T, Nambara E, Yamagishi K, Goto DB, Naito S. Storage proteins. The Arabidopsis book. American Society of Plant Biologists. 2002. pp. 1-12'},{id:"B15",body:'Higgins TJV. Synthesis and regulation of major proteins in seeds. Annual Review in Plant Physiology. 1984;35:191-221'},{id:"B16",body:'Gonzalez-Perez S, Arellano B. In: Phillips GO, Williams PA, editors. Handbook of Hydrocolloids. 2nd ed. Sawston, Cambridge: Woodhead Publishing in Food Science, Technology and Nutrition; 2009. pp. 0-27'},{id:"B17",body:'Youle RJ, Huang AHC. Albumin storage proteins in the protein bodies of Castor bean. Plant Physiology. 1978;61:13-16'},{id:"B18",body:'Mylne JS, Hara-Nishimura I, Rosengren KJ. Seed storage albumins: Biosynthesis, trafficking and structures. Functional Plant Biology. 2014;41:671-677'},{id:"B19",body:'Quiroga AV, Martınez EN, Anon MC. Amaranth globulin polypeptide heterogeneity. The Protein Journal. 2007;26:327'},{id:"B20",body:'Takaiwa F, Kikuchi S, Oono K. The structure of rice storage protein glutelin precursor deduced from cDNA. Federation of European Biochemical Societies. 1986;206:33-35'},{id:"B21",body:'Pedersen B, Hallgren L, Hansen I, Eggum BO. The nutritive value of amaranth grain (Amaranthus caudatus). Plant Foods for Human Nutrition. 1987;36:325-334'},{id:"B22",body:'Segura-Nieto M, Vazquez-Sanchez N, Rubio-Velazquez H, Olguin-Martinez LE, Rodriguez-Nester CE, Herrera-Estrella L. Characterization of amaranth (Amaranthus hypochondriacus L.) seed proteins. Journal of Agricultural and Food Chemistry. 1992;40:1553-1558'},{id:"B23",body:'Costea M, DeMason D. Stem morphology and anatomy in Amaranthus L. (Amaranthaceae), taxonomic significance. The Journal of the Torrey Botanical Society. 2001;128:254-281'},{id:"B24",body:'Adhikary D. Morphological Studies in the Amaranthus hybridus Species Complex (Amaranthaceae: Caryophyllales)2013. p. 109'},{id:"B25",body:'Coons MP. Relationships of Amaranthus caudatus. Economic Botany. 1982;36:129-146'},{id:"B26",body:'Park YJ, Nemoto K, Nishikawa T, Matsushima K, Minami M, Kawase M. Waxy strains of three amaranth grains raised by different mutations in the coding region. Molecular Breeding. 2010;25:623-635'},{id:"B27",body:'Okuno K, Sakaguchi S. Inheritance of starch characteristics in perisperm of Amaranthus hypochondriacus. Journal of Heredity. 1982;73:467-467'},{id:"B28",body:'Venskutonis PR, Kraujalis P. Nutritional components of amaranth seeds and vegetables: A review on composition, properties, and uses: Nutritional components of amaranth seeds and vegetable. Comprehensive Reviews in Food Science and Food Safety. 2013;12:381-412'},{id:"B29",body:'Capriles VD, Almeida EL, Ferreira RE, Arêas JAG, Steel CJ, Chang YK. Physical and sensory properties of regular and reduced-fat pound cakes with added amaranth flour. Cereal Chemistry. 2008;85:614-618'},{id:"B30",body:'Popa O, Elena N, Popa I, Nit S, Dinu-pârvu CE. Methods for obtaining and determination of squalene from natural sources. BioMed Research International. 2015;2015:1-16'},{id:"B31",body:'Chan P, Tomlinson B, Lee CB, Lee YS. Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia. Journal of Clinical Pharmacology. 1996;36:422-427'},{id:"B32",body:'Trichopoulou A, Katsouyanni K, Stuver S, Tzala L, Gnardellis C, Rimm E, et al. Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. Journal of the National Cancer Institute. 1995;87:110-116'},{id:"B33",body:'Keys A. Mediterranean diet and public health: Personal reflections. American Journal of Clinical Nutrition. 1995;61:1321-1323'},{id:"B34",body:'Owen RW, Mier W, Giacosa A, Hull WE, Spiegelhalder B, Bartsch H. Phenolic compounds and squalene in olive oils: The concentration and antioxidant potential of total phenols, simple phenols, secoiridoids, lignans and squalene. Food and Chemical Toxicology. 2000;38:647-659'},{id:"B35",body:'León-Camacho M, García-González DL, Aparicio R. A detailed and comprehensive study of amaranth (Amaranthus cruentus L.) oil fatty profile. European Food Research and Technology. 2014;213:349-355'},{id:"B36",body:'Berganza BE, Moran AW, Rodríguez MG, Coto NM, Santamaría M, Bressani R. Effect of variety and location on the total fat, fatty acids and squalene content of amaranth. Plant Foods for Human Nutrition. 2003;58:1-6'},{id:"B37",body:'He HP, Corke H. Oil and squalene in amaranthus grain and leaf. Journal of Agricultural and Food Chemistry. 2003;51:7913-7920'},{id:"B38",body:'Peter K, Gandhi P. Rediscovering the therapeutic potential of Amaranthus species: A review. Egyptian Journal of Basic and Applied Sciences. 2017;4:196-205'},{id:"B39",body:'Jimoh MO, Afolayan AJ, Lewu FB. Suitability of Amaranthus species for alleviating human dietary deficiencies. South African Journal of Botany. 2018;115:65-73'},{id:"B40",body:'Repo-Carrasco-Valencia R, Hellström JK, Pihlava J-M, Mattila PH. Flavonoids and other phenolic compounds in Andean indigenous grains: Quinoa (Chenopodium quinoa), kañiwa (Chenopodium pallidicaule) and kiwicha (Amaranthus caudatus). Food Chemistry. 2010;120:128-133'},{id:"B41",body:'Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum. Gastroenterology. 2001;120:636-651'},{id:"B42",body:'De La Barca AMC, Rojas-Martínez ME, Islas-Rubio AR, Cabrera-Chávez F. Gluten-free breads and cookies of raw and popped amaranth flours with attractive technological and nutritional qualities. Plant Foods for Human Nutrition. 2010;65:241-246'},{id:"B43",body:'Shewry PR, Hey SJ. Do we need to worry about eating wheat? Nutrition Bulletin. 2016;41:6-13'},{id:"B44",body:'Gallagher E, Kunkel A, Gormley TR, Arendt EK. The effect of dairy and rice powder addition on loaf and crumb characteristics, and on shelf life (intermediate and long-term) of gluten-free breads stored in a modified atmosphere. European Food Research and Technology. 2003;218:44-48'},{id:"B45",body:'Rizzello CG, Coda R, De Angelis M, Di Cagno R, Carnevali P, Gobbetti M. Long-term fungal inhibitory activity of water-soluble extract from Amaranthus spp. seeds during storage of gluten-free and wheat flour breads. International Journal of Food Microbiology. 2009;131:189-196'},{id:"B46",body:'Fiorda FA, Soares MS, da Silva FA, Grosmann MVE, Souto LRF.Microstructure, texture and colour of gluten-free pasta made with amaranth flour, cassava starch and cassava bagasse. Food Science and Technology. 2013;54:132-138'},{id:"B47",body:'Cabrera-Chávez F, Calderón de la Barca AM, Islas-Rubio AR, Marti A, Marengo M, Pagani MA, et al. Molecular rearrangements in extrusion processes for the production of amaranth-enriched, gluten-free rice pasta. LWT-Food Science and Technology. 2012;47:421-426'},{id:"B48",body:'Kurek MA, Karp S, Wyrwisz J, Niu Y. Physicochemical properties of dietary fibers extracted from gluten-free sources: Quinoa (Chenopodium quinoa), amaranth (Amaranthus caudatus) and millet (Panicum miliaceum). Food Hydrocolloids. 2018;85:321-330'},{id:"B49",body:'Salcedo-Chávez B, Osuna-Castro JA, Guevara-Lara F, Domínguez-Domínguez J, Paredes-López O. Optimization of the isoelectric precipitation method to obtain protein isolates from amaranth (Amaranthus cruentus) seeds. Journal of Agricultural and Food Chemistry. 2002;50:6515-6520'},{id:"B50",body:'Lyapkova NS, Loskutova NA, Maisuryan AN, Mazin VV, Korableva NP, Platonova TA, et al. Transformed potato plants carrying the gene of the antifungal peptide of Amaranthus caudatus. Applied Biochemistry and Microbiology. 2001;37:349-354'},{id:"B51",body:'Khan MI, Giridhar P. Plant betalains: Chemistry and biochemistry. Phytochemistry. 2015;117:267-295'},{id:"B52",body:'Strack D, Vogt T, Schliemann W. Recent advances in betalain research. Phytochemistry. 2003;62:247-269'},{id:"B53",body:'Cai Y, Sun M, Corke H. Antioxidant activity of betalains from plants of the Amaranthaceae. Journal of Agricultural and Food Chemistry. 2003;51:2288-2294'},{id:"B54",body:'Cai Y-Z, Sun M, Corke H. Characterization and application of betalain pigments from plants of the Amaranthaceae. Trends in Food Science & Technology. 2005;16:370-376'},{id:"B55",body:'Gengatharan A, Dykes GA, Choo WS. Betalains: Natural plant pigments with potential application in functional foods. LWT-Food Science and Technology. 2015;64:645-649'},{id:"B56",body:'Borkowski T, Szymusiak H, Gliszczyńska-Rwigło A, Rietjens IMCM, Tyrakowska B. Radical scavenging capacity of wine anthocyanins is strongly pH-dependent. Journal of Agricultural and Food Chemistry. 2005;53:5526-5534'},{id:"B57",body:'Esatbeyoglu T, Wagner AE, Motafakkerazad R, Nakajima Y, Matsugo S, Rimbach G. Free radical scavenging and antioxidant activity of betanin: Electron spin resonance spectroscopy studies and studies in cultured cells. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association. 2014;73:119-126'},{id:"B58",body:'Sreekanth D, Arunasree MK, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P. Betanin a betacyanin pigment purified from fruits of Opuntia ficus indica induces apoptosis in human chronic myeloid leukemia cell line-K562. Phytomedicine. 2007;14:739-746'},{id:"B59",body:'Hilou A, Nacoulma OG, Guiguemde TR. In vivo antimalarial activities of extracts from Amaranthus spinosus L. and Boerhaavia erecta L. in mice. Journal of Ethnopharmacology. 2006;103:236-240'},{id:"B60",body:'Čanadanović-Brunet JM, Savatović SS, Gordana S. Antioxidant and antimicrobial activities of beet root pomace extracts. Science. 2011;29:575-585'},{id:"B61",body:'Velićanski AS, Cvetković DD, Markov SL, Vulić JJ, Djilas SM. Antibacterial activity of Beta vulgaris L. pomace extract. Acta Periodica Technologica. 2011;42:263-269'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Dinesh Adhikary",address:"dinesh.adhikary@ubc.ca",affiliation:'
'}],corrections:null},book:{id:"8949",type:"book",title:"Nutritional Value of Amaranth",subtitle:null,fullTitle:"Nutritional Value of Amaranth",slug:"nutritional-value-of-amaranth",publishedDate:"March 18th 2020",bookSignature:"Viduranga Y. Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/8949.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83880-084-0",printIsbn:"978-1-83880-083-3",pdfIsbn:"978-1-83880-185-4",reviewType:"peer-reviewed",numberOfWosCitations:8,isAvailableForWebshopOrdering:!0,editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"323"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"70805",type:"chapter",title:"Amaranth as a Pseudocereal in Modern Times: Nutrients, Taxonomy, Morphology and Cultivation",slug:"amaranth-as-a-pseudocereal-in-modern-times-nutrients-taxonomy-morphology-and-cultivation",totalDownloads:755,totalCrossrefCites:0,signatures:"Asel C. Weerasekara and Viduranga Y. Waisundara",reviewType:"peer-reviewed",authors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",fullName:"Viduranga Y. Waisundara",slug:"viduranga-y.-waisundara"},{id:"309844",title:"Dr.",name:"Asel C.",middleName:null,surname:"Weerasekara",fullName:"Asel C. Weerasekara",slug:"asel-c.-weerasekara"}]},{id:"69525",type:"chapter",title:"Adaptation Strategies and Microwave Drying of Amaranth Species with a High Nutritional Value to the Ecuadorian Andean Region",slug:"adaptation-strategies-and-microwave-drying-of-amaranth-species-with-a-high-nutritional-value-to-the-",totalDownloads:657,totalCrossrefCites:0,signatures:"Carlos J. Torres-Miño, Rafael Hernández Maqueda and Ángel H. Moreno",reviewType:"peer-reviewed",authors:[{id:"305161",title:"Ph.D.",name:"Ángel",middleName:null,surname:"H. Moreno",fullName:"Ángel H. Moreno",slug:"angel-h.-moreno"},{id:"305164",title:"Dr.",name:"Rafael",middleName:null,surname:"Hernández Maqueda",fullName:"Rafael Hernández Maqueda",slug:"rafael-hernandez-maqueda"},{id:"305189",title:"Dr.",name:"Carlos J.",middleName:null,surname:"Torres-Miño",fullName:"Carlos J. Torres-Miño",slug:"carlos-j.-torres-mino"}]},{id:"69904",type:"chapter",title:"Value of Amaranthus [L.] Species in Nigeria",slug:"value-of-em-amaranthus-em-l-species-in-nigeria",totalDownloads:982,totalCrossrefCites:5,signatures:"Matthew Chidozie Ogwu",reviewType:"peer-reviewed",authors:[{id:"301124",title:"Dr.",name:"Matthew Chidozie",middleName:null,surname:"Ogwu",fullName:"Matthew Chidozie Ogwu",slug:"matthew-chidozie-ogwu"}]},{id:"68165",type:"chapter",title:"Amaranth: An Ancient and High-Quality Wholesome Crop",slug:"amaranth-an-ancient-and-high-quality-wholesome-crop",totalDownloads:700,totalCrossrefCites:4,signatures:"Dinesh Adhikary, Upama Khatri-Chhetri and Jan Slaski",reviewType:"peer-reviewed",authors:[{id:"299993",title:"Dr.",name:"Dinesh",middleName:null,surname:"Adhikary",fullName:"Dinesh Adhikary",slug:"dinesh-adhikary"},{id:"300684",title:"Ms.",name:"Upama",middleName:null,surname:"Khatri-Chhetri",fullName:"Upama Khatri-Chhetri",slug:"upama-khatri-chhetri"},{id:"308380",title:"Dr.",name:"Jan",middleName:null,surname:"Slaski",fullName:"Jan Slaski",slug:"jan-slaski"}]},{id:"70999",type:"chapter",title:"Potential of Amaranth in Alleviating Malnutrition in Indonesia",slug:"potential-of-amaranth-in-alleviating-malnutrition-in-indonesia",totalDownloads:570,totalCrossrefCites:0,signatures:"Muhammad Ikhsan Sulaiman and Rita Andini",reviewType:"peer-reviewed",authors:[{id:"304411",title:"Ph.D.",name:"Rita",middleName:null,surname:"Andini",fullName:"Rita Andini",slug:"rita-andini"},{id:"304416",title:"Dr.",name:"Muhammad Ikhsan",middleName:null,surname:"Sulaiman",fullName:"Muhammad Ikhsan Sulaiman",slug:"muhammad-ikhsan-sulaiman"}]},{id:"68895",type:"chapter",title:"Functional Value of Amaranth as Applied to Sports Nutrition",slug:"functional-value-of-amaranth-as-applied-to-sports-nutrition",totalDownloads:827,totalCrossrefCites:0,signatures:"Torregrosa-García Antonio and López-Román F. Javier",reviewType:"peer-reviewed",authors:[{id:"304203",title:"Ph.D. Student",name:"Antonio",middleName:null,surname:"Torregrosa-García",fullName:"Antonio Torregrosa-García",slug:"antonio-torregrosa-garcia"},{id:"304206",title:"Dr.",name:"Javier F.",middleName:null,surname:"López-Román",fullName:"Javier F. López-Román",slug:"javier-f.-lopez-roman"}]},{id:"67741",type:"chapter",title:"Nutritional Functional Value and Therapeutic Utilization of Amaranth",slug:"nutritional-functional-value-and-therapeutic-utilization-of-amaranth",totalDownloads:1181,totalCrossrefCites:7,signatures:"Manuel Soriano-García and Isabel Saraid Aguirre-Díaz",reviewType:"peer-reviewed",authors:[{id:"300752",title:"Prof.",name:"Manuel",middleName:null,surname:"Soriano-García",fullName:"Manuel Soriano-García",slug:"manuel-soriano-garcia"},{id:"317538",title:"Dr.",name:"Isabel Saraid",middleName:null,surname:"Aguirre-Díaz",fullName:"Isabel Saraid Aguirre-Díaz",slug:"isabel-saraid-aguirre-diaz"}]},{id:"68642",type:"chapter",title:"Effect of Various Process Conditions on the Nutritional and Bioactive Compounds of Amaranth",slug:"effect-of-various-process-conditions-on-the-nutritional-and-bioactive-compounds-of-amaranth",totalDownloads:798,totalCrossrefCites:1,signatures:"Ofelia Marquez-Molina and Leticia Xochitl Lopez-Martinez",reviewType:"peer-reviewed",authors:[{id:"301437",title:"Dr.",name:"Leticia Xochitl",middleName:null,surname:"Lopez-Martinez",fullName:"Leticia Xochitl Lopez-Martinez",slug:"leticia-xochitl-lopez-martinez"},{id:"308486",title:"Dr.",name:"Ofelia",middleName:null,surname:"Marquez-Molina",fullName:"Ofelia Marquez-Molina",slug:"ofelia-marquez-molina"}]},{id:"71167",type:"chapter",title:"Amaranth Seed Oil Composition",slug:"amaranth-seed-oil-composition",totalDownloads:906,totalCrossrefCites:5,signatures:"Parisa Nasirpour-Tabrizi, Sodeif Azadmard-Damirchi, Javad Hesari and Zahra Piravi-Vanak",reviewType:"peer-reviewed",authors:[{id:"279804",title:"Associate Prof.",name:"Zahra",middleName:null,surname:"Piravi-Vanak",fullName:"Zahra Piravi-Vanak",slug:"zahra-piravi-vanak"},{id:"312225",title:"Prof.",name:"Sodeif",middleName:null,surname:"Azadmard-Damirchi",fullName:"Sodeif Azadmard-Damirchi",slug:"sodeif-azadmard-damirchi"},{id:"318844",title:"Dr.",name:"Parisa",middleName:null,surname:"Nasirpour-Tabrizi",fullName:"Parisa Nasirpour-Tabrizi",slug:"parisa-nasirpour-tabrizi"},{id:"318845",title:"Dr.",name:"Javad",middleName:null,surname:"Hesari",fullName:"Javad Hesari",slug:"javad-hesari"}]},{id:"68401",type:"chapter",title:"Kinetics and Thermodynamics of Oil Extracted from Amaranth",slug:"kinetics-and-thermodynamics-of-oil-extracted-from-amaranth",totalDownloads:942,totalCrossrefCites:5,signatures:"Chinedu M. Agu and Albert C. Agulanna",reviewType:"peer-reviewed",authors:[{id:"299277",title:"Ph.D.",name:"Chinedu M.",middleName:null,surname:"Agu",fullName:"Chinedu M. Agu",slug:"chinedu-m.-agu"},{id:"308966",title:"MSc.",name:"Albert C.",middleName:null,surname:"Agulanna",fullName:"Albert C. Agulanna",slug:"albert-c.-agulanna"}]}]},relatedBooks:[{type:"book",id:"6155",title:"Diabetes Food Plan",subtitle:null,isOpenForSubmission:!1,hash:"b826ff12304ae270954a41210f4e1582",slug:"diabetes-food-plan",bookSignature:"Viduranga Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/6155.jpg",editedByType:"Edited by",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"58954",title:"Introductory Chapter: The Need for Dietary Interventions for Diabetes",slug:"introductory-chapter-the-need-for-dietary-interventions-for-diabetes",signatures:"Viduranga Yashasvi Waisundara",authors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",fullName:"Viduranga Y. Waisundara",slug:"viduranga-y.-waisundara"}]},{id:"61271",title:"The Microbiome and the Epigenetics of Diabetes Mellitus",slug:"the-microbiome-and-the-epigenetics-of-diabetes-mellitus",signatures:"Lissé Angarita Dávila, Valmore Bermúdez Pirela, Waldo Díaz, Nadia\nReyna Villasmil, Silvana Cisternas León, Ma Cristina Escobar\nContreras, Kristian Buhring Bonacich, Samuel Durán Agüero, Paula\nCarrasco Vergara, Rodrigo Buhring Bonacich, Constanza Bugman,\nVirginia Céspedes, Marcell Gatica, Marion Guerrero Wyss,\nJorge González Casanova and Francisco Valdebenito",authors:[{id:"41236",title:"Dr.",name:"Valmore",middleName:null,surname:"Bermúdez",fullName:"Valmore Bermúdez",slug:"valmore-bermudez"},{id:"217192",title:"Ph.D.",name:"Lissé",middleName:null,surname:"Angarita Dávila",fullName:"Lissé Angarita Dávila",slug:"lisse-angarita-davila"},{id:"218793",title:"Dr.",name:"Nadia Reyna",middleName:null,surname:"Reyna Villasmil",fullName:"Nadia Reyna Reyna Villasmil",slug:"nadia-reyna-reyna-villasmil"},{id:"218794",title:"Dr.",name:"Samuel",middleName:null,surname:"Durán Agüero",fullName:"Samuel Durán Agüero",slug:"samuel-duran-aguero"},{id:"218795",title:"Dr.",name:"Waldo",middleName:null,surname:"Díaz",fullName:"Waldo Díaz",slug:"waldo-diaz"},{id:"218796",title:"MSc.",name:"Ma Cristina",middleName:null,surname:"Escobar Contreras",fullName:"Ma Cristina Escobar Contreras",slug:"ma-cristina-escobar-contreras"},{id:"218800",title:"MSc.",name:"Kristian",middleName:null,surname:"Bühring Bonacich",fullName:"Kristian Bühring Bonacich",slug:"kristian-buhring-bonacich"},{id:"218801",title:"MSc.",name:"Paula",middleName:null,surname:"Carrasco Vergara",fullName:"Paula Carrasco Vergara",slug:"paula-carrasco-vergara"},{id:"223462",title:"MSc.",name:"Silvana",middleName:null,surname:"Cisternas",fullName:"Silvana Cisternas",slug:"silvana-cisternas"},{id:"223468",title:"MSc.",name:"Marion",middleName:null,surname:"Guerrero Wyss",fullName:"Marion Guerrero Wyss",slug:"marion-guerrero-wyss"},{id:"223473",title:"MSc.",name:"Virginia",middleName:null,surname:"Cespedes",fullName:"Virginia Cespedes",slug:"virginia-cespedes"},{id:"223477",title:"Dr.",name:"Marcell",middleName:null,surname:"Gatica",fullName:"Marcell Gatica",slug:"marcell-gatica"},{id:"223478",title:"MSc.",name:"Rodrigo",middleName:null,surname:"Buhring",fullName:"Rodrigo Buhring",slug:"rodrigo-buhring"},{id:"223970",title:"MSc.",name:"Constanza",middleName:null,surname:"Bugmann",fullName:"Constanza Bugmann",slug:"constanza-bugmann"},{id:"239591",title:"Prof.",name:"Francisco",middleName:null,surname:"Valdebenito",fullName:"Francisco Valdebenito",slug:"francisco-valdebenito"}]},{id:"57473",title:"Dietary Recommendations for Patients with Cardiovascular Disease and Diabetes",slug:"dietary-recommendations-for-patients-with-cardiovascular-disease-and-diabetes",signatures:"Vlad Cristina",authors:[{id:"210388",title:"Ph.D.",name:"Vlad",middleName:"I",surname:"Cristina",fullName:"Vlad Cristina",slug:"vlad-cristina"}]},{id:"58514",title:"Antidiabetic and Safety Properties of Ethanolic Leaf Extract of Corchorus olitorius in Alloxan-Induced Diabetic Rats",slug:"antidiabetic-and-safety-properties-of-ethanolic-leaf-extract-of-corchorus-olitorius-in-alloxan-induc",signatures:"Arise Rotimi Olusanya, Bankole S. Ifeoluwa, Aboyewa Jumoke A.\nand Bobbo Khadijat",authors:[{id:"217205",title:"Dr.",name:"Rotimi",middleName:null,surname:"Arise",fullName:"Rotimi Arise",slug:"rotimi-arise"},{id:"220514",title:"Dr.",name:"Ifeoluwa",middleName:null,surname:"Bankole",fullName:"Ifeoluwa Bankole",slug:"ifeoluwa-bankole"},{id:"221006",title:"Ms.",name:"Jumoke",middleName:null,surname:"Aboyewa",fullName:"Jumoke Aboyewa",slug:"jumoke-aboyewa"},{id:"221007",title:"Ms.",name:"Khadijat",middleName:null,surname:"Bobbo",fullName:"Khadijat Bobbo",slug:"khadijat-bobbo"}]},{id:"62023",title:"Low-Carbohydrate High-Fat (LCHF) Diet: Evidence of Its Benefits",slug:"low-carbohydrate-high-fat-lchf-diet-evidence-of-its-benefits",signatures:"Parijat De and Sagnik Mukhopadhyay",authors:[{id:"210442",title:"Dr.",name:"Parijat",middleName:null,surname:"De",fullName:"Parijat De",slug:"parijat-de"}]},{id:"57204",title:"Trace Elements Modulates Oxidative Stress in Type 2 Diabetes",slug:"trace-elements-modulates-oxidative-stress-in-type-2-diabetes",signatures:"Ines Gouaref and Elhadj-Ahmed Koceir",authors:[{id:"217216",title:"Prof.",name:"Elhadj-Ahmed",middleName:null,surname:"Koceir",fullName:"Elhadj-Ahmed Koceir",slug:"elhadj-ahmed-koceir"},{id:"221212",title:"Dr.",name:"Ines",middleName:null,surname:"Gouaref",fullName:"Ines Gouaref",slug:"ines-gouaref"}]},{id:"61758",title:"Savior of Diabetes: Antioxidants",slug:"savior-of-diabetes-antioxidants",signatures:"Zar Chi Thent and Azian Abd Latiff",authors:[{id:"217365",title:"Dr.",name:"Zar Chi",middleName:null,surname:"Thent",fullName:"Zar Chi Thent",slug:"zar-chi-thent"},{id:"219580",title:"Prof.",name:"Azian Abd",middleName:null,surname:"Latiff",fullName:"Azian Abd Latiff",slug:"azian-abd-latiff"}]},{id:"60464",title:"Influence of Glycaemic Control on Cognitive Function in Diabetic Children and Adolescents",slug:"influence-of-glycaemic-control-on-cognitive-function-in-diabetic-children-and-adolescents",signatures:"Estefanía Diéguez Castillo, Ana Nieto-Ruíz, Mireia Escudero-Marín\nand Cristina Campoy",authors:[{id:"90805",title:"Prof.",name:"Cristina",middleName:null,surname:"Campoy",fullName:"Cristina Campoy",slug:"cristina-campoy"},{id:"211059",title:"BSc.",name:"Estefanía",middleName:null,surname:"Diéguez Castillo",fullName:"Estefanía Diéguez Castillo",slug:"estefania-dieguez-castillo"},{id:"233102",title:"BSc.",name:"Ana",middleName:null,surname:"Nieto",fullName:"Ana Nieto",slug:"ana-nieto"},{id:"233103",title:"BSc.",name:"Mireia",middleName:null,surname:"Escudero",fullName:"Mireia Escudero",slug:"mireia-escudero"}]},{id:"57565",title:"Medical Nutrition Therapy for Special Groups with Diabetes Mellitus",slug:"medical-nutrition-therapy-for-special-groups-with-diabetes-mellitus",signatures:"Muhammed Kizilgul, Meltem Mermer and Bekir Ucan",authors:[{id:"210376",title:"Dr.",name:"Muhammed",middleName:null,surname:"Kizilgul",fullName:"Muhammed Kizilgul",slug:"muhammed-kizilgul"},{id:"211906",title:"Ph.D. Student",name:"Meltem",middleName:null,surname:"Mermer",fullName:"Meltem Mermer",slug:"meltem-mermer"},{id:"223836",title:"Dr.",name:"Bekir",middleName:null,surname:"Ucan",fullName:"Bekir Ucan",slug:"bekir-ucan"}]},{id:"57442",title:"Exercise and Diabetes Mellitus",slug:"exercise-and-diabetes-mellitus",signatures:"Asmare Yitayeh Gelaw",authors:[{id:"210348",title:"Mr.",name:"Asmare Yitayeh",middleName:null,surname:"Gelaw",fullName:"Asmare Yitayeh Gelaw",slug:"asmare-yitayeh-gelaw"}]},{id:"61320",title:"New Insights into Alleviating Diabetes Mellitus: Role of Gut Microbiota and a Nutrigenomic Approach",slug:"new-insights-into-alleviating-diabetes-mellitus-role-of-gut-microbiota-and-a-nutrigenomic-approach",signatures:"Lissé Angarita Dávila, Valmore Bermúdez Pirela, Nadia Reyna\nVillasmil, Silvana Cisternas, Waldo Díaz, Ma Cristina Escobar, Paula\nCarrasco, Samuel Durán, Kristian Buhring, Rodrigo Buhring,\nConstanza Bugman, Virginia Céspedes, Marcell Gatica, Diana Rojas,\nMarion Guerrero Wyss and Francisco Valdebenito",authors:[{id:"41236",title:"Dr.",name:"Valmore",middleName:null,surname:"Bermúdez",fullName:"Valmore Bermúdez",slug:"valmore-bermudez"},{id:"217192",title:"Ph.D.",name:"Lissé",middleName:null,surname:"Angarita Dávila",fullName:"Lissé Angarita Dávila",slug:"lisse-angarita-davila"},{id:"218793",title:"Dr.",name:"Nadia Reyna",middleName:null,surname:"Reyna Villasmil",fullName:"Nadia Reyna Reyna Villasmil",slug:"nadia-reyna-reyna-villasmil"},{id:"218794",title:"Dr.",name:"Samuel",middleName:null,surname:"Durán Agüero",fullName:"Samuel Durán Agüero",slug:"samuel-duran-aguero"},{id:"218795",title:"Dr.",name:"Waldo",middleName:null,surname:"Díaz",fullName:"Waldo Díaz",slug:"waldo-diaz"},{id:"218796",title:"MSc.",name:"Ma Cristina",middleName:null,surname:"Escobar Contreras",fullName:"Ma Cristina Escobar Contreras",slug:"ma-cristina-escobar-contreras"},{id:"218800",title:"MSc.",name:"Kristian",middleName:null,surname:"Bühring Bonacich",fullName:"Kristian Bühring Bonacich",slug:"kristian-buhring-bonacich"},{id:"218801",title:"MSc.",name:"Paula",middleName:null,surname:"Carrasco Vergara",fullName:"Paula Carrasco Vergara",slug:"paula-carrasco-vergara"},{id:"223462",title:"MSc.",name:"Silvana",middleName:null,surname:"Cisternas",fullName:"Silvana Cisternas",slug:"silvana-cisternas"},{id:"223468",title:"MSc.",name:"Marion",middleName:null,surname:"Guerrero Wyss",fullName:"Marion Guerrero Wyss",slug:"marion-guerrero-wyss"},{id:"223473",title:"MSc.",name:"Virginia",middleName:null,surname:"Cespedes",fullName:"Virginia Cespedes",slug:"virginia-cespedes"},{id:"223477",title:"Dr.",name:"Marcell",middleName:null,surname:"Gatica",fullName:"Marcell Gatica",slug:"marcell-gatica"},{id:"223478",title:"MSc.",name:"Rodrigo",middleName:null,surname:"Buhring",fullName:"Rodrigo Buhring",slug:"rodrigo-buhring"},{id:"223970",title:"MSc.",name:"Constanza",middleName:null,surname:"Bugmann",fullName:"Constanza Bugmann",slug:"constanza-bugmann"},{id:"239591",title:"Prof.",name:"Francisco",middleName:null,surname:"Valdebenito",fullName:"Francisco Valdebenito",slug:"francisco-valdebenito"},{id:"248969",title:"Dr.",name:"Diana",middleName:null,surname:"Rojas",fullName:"Diana Rojas",slug:"diana-rojas"}]}]}],publishedBooks:[{type:"book",id:"2066",title:"Milk Production",subtitle:"Advanced Genetic Traits, Cellular Mechanism, Animal Management and Health",isOpenForSubmission:!1,hash:"0bce9f57b06503666b182457b414a9de",slug:"milk-production-advanced-genetic-traits-cellular-mechanism-animal-management-and-health",bookSignature:"Narongsak Chaiyabutr",coverURL:"https://cdn.intechopen.com/books/images_new/2066.jpg",editedByType:"Edited by",editors:[{id:"76047",title:"Prof.",name:"Narongsak",surname:"Chaiyabutr",slug:"narongsak-chaiyabutr",fullName:"Narongsak Chaiyabutr"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9722",title:"Milk Substitutes",subtitle:"Selected Aspects",isOpenForSubmission:!1,hash:"cc91d4cfca40c9ba47bbe34b2f8e8a3e",slug:"milk-substitutes-selected-aspects",bookSignature:"Małgorzata Ziarno",coverURL:"https://cdn.intechopen.com/books/images_new/9722.jpg",editedByType:"Edited by",editors:[{id:"303881",title:"Prof.",name:"Małgorzata",surname:"Ziarno",slug:"malgorzata-ziarno",fullName:"Małgorzata Ziarno"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6155",title:"Diabetes Food Plan",subtitle:null,isOpenForSubmission:!1,hash:"b826ff12304ae270954a41210f4e1582",slug:"diabetes-food-plan",bookSignature:"Viduranga Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/6155.jpg",editedByType:"Edited by",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10440",title:"Nuts and Nut Products in Human Health and Nutrition",subtitle:null,isOpenForSubmission:!1,hash:"4a103c51832749a8c5e73020dcc46194",slug:"nuts-and-nut-products-in-human-health-and-nutrition",bookSignature:"Venketeshwer Rao, Leticia Rao, Md Ahiduzzaman and A. K. M. Aminul Islam",coverURL:"https://cdn.intechopen.com/books/images_new/10440.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6538",title:"Current Topics on Superfoods",subtitle:null,isOpenForSubmission:!1,hash:"42525eaf5a539bc1e2318f4eb8dfea5a",slug:"current-topics-on-superfoods",bookSignature:"Naofumi Shiomi",coverURL:"https://cdn.intechopen.com/books/images_new/6538.jpg",editedByType:"Edited by",editors:[{id:"163777",title:"Dr.",name:"Naofumi",surname:"Shiomi",slug:"naofumi-shiomi",fullName:"Naofumi Shiomi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"8949",title:"Nutritional Value of Amaranth",subtitle:null,isOpenForSubmission:!1,hash:"2af686a663e37e1f663013cd1e3acbe0",slug:"nutritional-value-of-amaranth",bookSignature:"Viduranga Y. Waisundara",coverURL:"https://cdn.intechopen.com/books/images_new/8949.jpg",editedByType:"Edited by",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"76679",title:"Endocrine Manifestations of Systemic Lupus Erythematosus",doi:"10.5772/intechopen.97363",slug:"endocrine-manifestations-of-systemic-lupus-erythematosus",body:'
1. Introduction
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting all organ systems [1]. It affects mainly joints, skin, blood vessels, heart, lung, kidneys, liver and the nervous system [2]. It is the prototype of systemic autoimmune diseases. In patients with SLE the immune system attacks tissues and cells leading to inflammation and damage [3]. The course of SLE is variable, and maybe either mild or severe leading sometimes to fatal damage and death [4]. The disease is characterized by periods of exacerbation, which are called flares and periods of remission [5]. SLE occurs nine times more often in the female gender mainly in the reproductive age, and it is more frequent in people of non-European descent [6]. Different types of autoantibodies are present in SLE patients [7]. The B lymphocyte is believed to play a major pathogenic role in the disease and many different autoantibodies are detected, therefore the disease is classified as a “B-cell disease” [8, 9]. However, T lymphocytes also play a role in the immunopathogenesis of SLE [10]. Because of the presence of many different autoantibodies, SLE is classified as a “B-cell disease.” Patients with SLE present with symptoms and inflammatory involvement that can affect virtually every organ [11]. The main features of SLE include the production of antinuclear antibodies and the deposition of immune complexes in basement membranes throughout the body where they induce an inflammatory response [12, 13]. Genetic, epigenetic, and environmental factors contribute to the development of this autoimmune process. Endocrine manifestations as expected also occur in patients with systemic lupus erythematosus [14] (Figure 1). Hypothyroidism has been observed in a higher rate than that expected in the general population. Hyperthyroidism has also been observed. Autoimmune Hashimoto’s thyroiditis has been observed in a higher rate than that expected in the general population. Graves’ disease has been observed in patients with SLE. Hyperparathyroidism has been observed in patients with SLE, mainly in the context of lupus nephritis. Hypoparathyroidism has also been observed. Autoimmune oophoritis leading to ovarian failure has been observed in patients with SLE. Despite the multisystem nature of the disease, it appears that it respects the adrenals, so that Addison’s disease is extremely rare in SLE.
Figure 1.
Common endocrine disorders in systemic lupus erythematosus.
2. The neuroendocrine axis in systemic lupus erythematosus
SLE is a systemic autoimmune disease characterized by a loss of self-tolerance [15]. The immune system is activated in the disease and pro-inflammatory cytokines are secreted [16]. The immune system and the neuroendocrine system are interconnected [17]. The two systems interact in a bidirectional manner (Figure 2). During the autoimmune inflammatory response cytokines released from immune cells affect the neuroendocrine axis [18, 19]. In turn the neuroendocrine system secretes hormones which modulate the immune response [20].
Figure 2.
The interaction between the neuroendocrine and immune systems in systemic lupus erythematosus.
The main target of activation by cytokines is the hypothalamic–pituitary–adrenal (HPA) axis. Interleukin (IL) -1a and -1b, IL-6 and tumor necrosis factor (TNF)-a, which are released sequentially from macrophages upon activation, are powerful activators of the HPA axis. In vitro studies in isolated hypothalamic tissue have shown the ability of IL-1a, IL-1b, IL-6, IL-8 and TNF-a to initiate the release of corticotropin-releasing hormone (CRH) [21, 22]. In humans, a blunted HPA axis response to stimulation with hypoglycemia or CRH was shown in several autoimmune diseases, including rheumatoid arthritis, Sjogren’s syndrome, fibromyalgia and SLE [23]. However, the relationship between HPA axis reactivity and inflammatory disease was challenged by experiments which showed that in high-stress situations, rats who had a robust corticosterone-response to stress developed more severe inflammation than rats who had a less profound corticosterone response [24]. Differences in the HPA axis response to stress may discriminate patients who seem to have the same disease, but may have different responses to treatment [25]. The HPA axis in important in regulating disease severity in SLE. However, the development of the disease may alter the HPA axis response.
Prolactin (PRL) is a peptide hormone produced by the anterior pituitary. PRL can be produced by lymphocytes, which in turn express PRL receptors [26, 27]. Thus, PRL may have immunomodulatory functions [27, 28, 29]. Increased PRL levels have been observed in male and female patients with lupus [30, 31]. Furthermore, suppression of PRL secretion with bromocriptine provides beneficial effects in murine lupus and possibly in lupus patients [32]. Treatment with PRL breaks tolerance and induces a lupus like illness in autoimmune mice. PRL is in effect also a cytokine [29]. PRL receptors are distributed in the immune system [33]. Mild and moderate hyperprolactinemia has been demonstrated in 20–30% of SLE patients and was associated with active disease. Hyperprolactinemia may have a role in lupus nephritis and CNS involvement of patients who have SLE [34]. Elevated PRL levels were associated with increased disease activity in SLE and prolactin may have a pathogenic role in SLE [35]. Thus, PRL, a peptide hormone derived from the anterior pituitary gland and lymphocytes participates in the regulation of the immune response, stimulates immune cells and belongs to a network of immune endocrine interaction. Hyperprolactinemia has been found in SLE and PRL may participate in SLE activation during pregnancy [35]. High levels of prolactin may lead to the development or the exacerbation of an autoimmune disease such as SLE [36]. Prolactin is a bioactive hormone acting both as a hormone as well as a cytokine and it may act as an immunomodulator affecting the negative selection of autoreactive B lymphocytes [29].
2.1 Stress and systemic lupus erythematosus
The adrenergic nervous system runs from the CNS to lymphoid organs, namely the thymus, spleen and lymph nodes. Its effects are mediated by noradrenaline which acts through the relevant receptors [37]. Noradrenaline receptors are expressed by immune cells, namely T and B lymphocytes and macrophages [38]. Noradrenaline and adrenaline stimulate IL-10 and transforming growth factor-b production, thus enhancing Th2 immunity [39, 40]. In SLE, a disease driven by excess IL-10, disease activity may increase during states of high catecholamine release, such as acute stress. In a prospective study of patients with SLE, disease flares were associated with emotional stress or with the number or severity of daily stressors [41, 42]. Additionally, the effect of acute psychological stress induced differential immune response in SLE patients as compared to controls [43].
The hypothalamic–pituitary–adrenal axis responds to inflammatory cytokines [44]. It has been demonstrated that inflammatory cytokines, such as IL-1a and IL-1b, IL-6 and TNF-a are powerful activators of the hypothalamic–pituitary–adrenal axis [45, 46]. In SLE patients with central nervous system involvement elevated levels of inflammatory cytokines were observed in the cerebrospinal fluid [47] suggesting an involvement of these inflammatory cytokines in disease pathogenesis.
2.2 Estrogens in the pathogenesis of systemic lupus erythematosus
SLE is a disease affecting primarily female patients in the reproductive age [48]. Evidence exists implicating estrogens in the pathogenesis of SLE [49]. An extensive cross-talk takes place between estrogen and the immune system. Estrogens are a major modulating factor of the immune response [50] (Figure 3). Epidemiological evidence implicates estrogens in the pathogenesis of SLE, as during childhood where estrogen secretion is minimal the female: male ratio is 3:1 as opposed to 9:1 in the reproductive age. In the postmenopausal period the ratio is 8:1 [51]. Evidence has shown that women with early menarche, or treated with oral contraceptives or hormone replacement therapy have an increased risk for SLE [52, 53]. The presence of the X chromosome appears also to be important for the pathogenesis of SLE. There appears to be a gene dose effect, as the prevalence of SLE in Klinefelter’s syndrome (XXY) is 14-fold that in the general male population, whereas it is decreased in female patients with Turner’s syndrome (XO) [54]. Pregnancy, in which the concentration of estrogens is extremely increased can cause a disease flare or even trigger the development of lupus [55, 56]. The puerperium is characterized by an increased risk for disease relapse [57]. Hormonal factors used for ovulation induction and in vitro fertilization may cause disease flare in SLE [52].
Figure 3.
The effect of estrogens on the immune system.
The main pathophysiologic processes of SLE are the loss of self-tolerance and the production of autoantibodies with consequent inflammatory response and organ injury [15]. Estrogens are capable of inducing these alterations in the immune system. Treg cells, immunosuppressive regulatory T cells, play an important role in the maintenance of self-tolerance and the prevention of autoimmunity. SLE patients have decreased numbers of Treg cells. Estradiol diminishes Treg cells [52, 58, 59]. In SLE, there is a switch from a type 1 (Th1) to a type 2 (Th2) T cell response where serum levels of Th2 cytokines, such as interleukin 4 (IL-4), IL-6, and IL-10, are elevated and there is decreased production of Th1 cytokines, such as IL-2 and interferon γ [60, 61, 62]. Estrogens alter Th1/Th2 ratio thus altering the balance between cellular and humoral immunity. Estrogens induce the development of Th2 lymphocytes and B cell hyperactivity leading to enhanced antibody production [63]. Estrogens promote the life span of lymphocytes by decreasing apoptosis of T and B cells [64]. Thus, estrogens seem to play a key role in the development of autoimmunity. They suppress self-tolerance reducing Treg cells [65]. They alter the Th1/Th2 ratio, favoring the predominance of humoral immunity. They prevent the deletion of autoreactive B cells [66]. They induce the generation of autoantibodies and they stimulate the production of inflammatory cytokines [67].
3. Endocrine disorders in systemic lupus erythematosus
3.1 Thyroid disease in SLE
Autoimmune thyroid disease has been observed in patients with systemic lupus erythematosus, such as autoimmune Hashimoto’s thyroiditis, hypothyroidism and Graves’ disease.
3.1.1 Hypothyroidism
Hypothyroidism is observed in patients with SLE in a higher rate than in the normal population. In particular, Munoz and Isenberg [14] reported a rate of 5.22% hypothyroidism, i.e. 37 patients, in their cohort of 708 patients with SLE in University College of London Hospital, as compared to 1–2% in the general UK population. In this cohort the onset of hypothyroidism occurred after the onset of SLE oftener. Other reports confirmed a higher than in the general population rate of hypothyroidism in SLE. In particular, Ong and Choy [68] in a Malaysian population of SLE patients observed a prevalence of hypothyroidism of 3.7%. Antonelli et al. [69] reported a prevalence of hypothyroidism of 4.5%. In an earlier report from the University College of London Hospital SLE cohort Pyne and Isenberg [70] reported a prevalence of hypothyroidism of 5.7%.
3.1.2 Hyperthyroidism
Hyperthyroidism is observed in patients with SLE. In their cohort of 708 patients with SLE Munoz and Isenberg [14] observed a prevalence of hyperthyroidism of 1.41% (10/708 SLE patients), similar to that in the general population [71]. Watad et al [72] and Ong et al [68] reported a prevalence of hyperthyroidism in SLE patients of 2.59% and 2.6%, respectively. Chan et al [73] observed a prevalence of 5.8% of hyperthyroidism in a study of 69 SLE patients. However, only 2.9% had a clinical hyperthyroidism.
3.1.3 Autoimmune Hashimoto’s thyroiditis
Autoimmune Hashimoto’s thyroiditis is frequently observed in patients with SLE. The prevalence of Hashimoto’s thyroiditis in patients with SLE as opposed to control subjects was investigated in a study [74]. The association of Hashinoto’s Hashimoto’s thyroiditis and anti-thyroid antibodies to the clinical, serological profile and disease activity as well as cumulative organ damage in this group was also investigated. In a group of 301 SLE patients and 141 controls TSH levels, T4 levels, antiTg antibodies and antiTPO antibodies were measured by chemiluminescence and immunometric methods. The serological and clinical profile of the patients was reviewed. SLE disease activity was measured using the SLEDAI index. The prevalence of Hashimoto’s thyroiditis was 12.6% in SLE as opposed to 5.6% in controls, the difference being statistically significant. A lower prevalence of malar rash and a higher prevalence of anti-Sm was noted in lupus patients with Hashimoto’s thyroiditis. No association was noted between Hashimoto’s thyroiditis and disease activity of cumulative organ damage. In conclusion, a two-fold increased risk of Hashimoto’s thyroiditis was noted in lupus patients. In a study performed in China 63 cases of lupus patients who also had Hashimoto’s thyroiditis were studied [75]. Lupus patients were classified in four groups, those in remission, those with low disease activity, those with moderate and those with high disease activity. Free T3 levels were found to be negatively correlated with disease activity. In an effort to find a way to treat effectively Hashimoto’s thyroiditis and SLE a group of scientists [76] injected human amniotic epithelial cells in murine models of Hashimoto’s thyroiditis and SLE. They observed that levels of antiTg, antiTPO antibodies and TSH levels decreased as well as evidence of tissue destruction within the thyroid decreased. Additionally, the injection of human amniotic epithelial cells induced the disappearance of antidsDNA antibodies and ANA in mice with SLE and improved immunoglobulin profiles. It downregulated the ratio of Th17/Treg cells in both Hashimoto thyroiditis and SLE mice and upregulated the proportion of B10 cells. Human epithelial amniotic cells suppressed the levels of pro-inflammatory cytokines, IL-17A and IFN-γ and enhanced TGF-β in the murine models of Hashimoto’s thyroiditis and SLE, thus suggesting a common pathogenic substrate in both diseases.
3.1.4 Graves’ disease
Graves’ disease is a systemic autoimmune disease with multiple manifestations, affecting the thyroid, the eyes and the skin [77]. Cases of Graves’ disease have been described in patients with SLE [78]. The case of a patient with Graves’ disease who later developed SLE has been described in the literature [79].
3.2 Pancreatic dysfunction in SLE pathogenesis and form
3.2.1 Diabetes mellitus 1
Cases of diabetes mellitus 1 have been described in SLE. In a cohort of SLE patients in the UK the prevalence of diabetes mellitus 1 was investigated [80]. The coexistence of diabetes mellitus 1, SLE and celiac disease has been described in a young female patient [81]. It appears that diabetes mellitus 1 is rare among SLE patients. However, the risk of developing renal disease, retinal disease and peripheral neuropathy requires careful follow up of the patients. It is also important for the physician to decide which complication is due to lupus or diabetes as the management is different.
3.2.2 Diabetes mellitus 2
Diabetes mellitus type 2 is reported with increasing frequency nowadays [82]. Hence, diabetes mellitus 2 has been reported in patients with SLE. In their cohort of 485 SLE patients Cortes et al. [80] reported 4 patients with diabetes mellitus 2 and two considered to have steroid induced diabetes mellitus. Thus, it appears that diabetes mellitus 2 is infrequent within lupus patients. This may be due to the fact, that lupus develops in a younger age than diabetes mellitus 2 [14]. The relationship between SLE and gestational diabetes has been studied in a meta-analysis [83]. It was found that SLE does not seem to increase the risk of gestational diabetes. However, steroid use in SLE may increase the risk of gestational diabetes.
3.3 Parathyroid disease in SLE
3.3.1 Hyperparathyroidism
Primary hyperparathyroidism is frequently recognized nowadays due to the routine measurement of serum calcium levels. Primary hyperparathyroidism has been reported in patients with lupus. However, there are just a few case reports in the literature of patients with SLE and primary hyperparathyroidism. Primary hyperparathyroidism due to the presence of a parathyroid adenoma in a 47-year old female patient with SLE has been described [84]. Hypercalcemia resolved in this patient after removal of the adenoma. Primary hyperparathyroidism due to a cystic parathyroid adenoma has also been described in a 62-year old female patient with SLE [85]. In their cohort of 708 lupus patients Munoz and Isenberg [14] also identified 5 (0.70%) patients with hyperparathyroidism, 1 with primary hyperparathyroidism and 4 patients with secondary hyperparathyroidism in the context of chronic renal failure due to lupus nephritis. Hyperparathyroidism presented after lupus in all cases described.
3.4 Adrenal disease in SLE
3.4.1 Addison’s disease
Addison’s disease has been reported in patients with SLE. However, there are only a few case reports of Addison’s disease in patients with SLE. The case of a 29-year old female patient who presented with Addisonian crisis in the presence of SLE and responded therapeutically to corticosteroids, both as far as Addison’s and lupus is concerned has been described [86]. In their cohort of lupus patients Munoz and Isenberg [14] did not identify any patient with Addison’s disease. It appears that Addison’s disease is a rare occurrence in lupus patients.
3.4.2 Cushing’s syndrome
The occurrence of Cushing’s syndrome due to an adrenal adenoma in patients with SLE is rare. The case of an 18-year old female patient with subclinical Cushing’s syndrome who developed lupus has been described [87]. The patient was successfully treated by surgical removal of the adrenal adenoma. A case of a 51-year old woman with SLE who developed Cushing’s syndrome and was found to have a left adrenal adenoma has been described [88]. The patient was successfully managed by laparascopic left adrenalectomy.
4. Ovarian function
Reproductive function of young female patients with SLE is commonly perturbed by various pathophysiologic mechanisms [89]. Ovarian reserve is diminished even in the presence of mild lupus suggesting a direct effect of the disease itself on ovarian function [90, 91] (Figure 4). It is possible that the underlying process is autoimmune oophoritis [92, 93, 94]. The clinical manifestations of these abnormalities are menstrual irregularity, amenorrhea, or premature ovarian failure. Menstrual irregularities are frequently observed in patients with SLE, and many of them are associated with the activity of the disease [95]. SLE itself induces dysfunction in the hypothalamic–pituitary-ovarian axis and elevates serum prolactin [35, 96, 97]. A study compared the levels of anti–müllerian hormone (AMH) as a marker of ovarian reserve between SLE patients and control subjects and found that SLE patients had significantly lower AMH levels than did the control subjects. No correlation was observed between disease activity and AMH levels [91]. Female SLE patients may have subfertility issues due to active disease, the use of immunosuppressive medications and delayed childbearing [98]. These findings show that SLE itself has a negative influence on ovarian reserve and function.
Figure 4.
Factors adversely affecting ovarian function in systemic lupus erythematosus.
SLE patients presenting with severe manifestations of the disease are treated with the alkylating agent cyclophosphamide [99, 100]. Cyclophosphamide is toxic to the ovaries [101, 102, 103]. SLE patients exposed to cyclophosphamide have a much higher risk of developing premature ovarian failure and infertility as compared to those receiving less toxic agents [91, 95, 104]. Cyclophosphamide leads to a decrease in reproductive life span and possibly premature ovarian failure. If the loss of ovarian function develops during or shortly after the completion of therapy, it is termed acute ovarian failure. For those who retain ovarian function after the completion of chemotherapy, a subset will go on to develop premature menopause before the age of 40 [105]. The clinical manifestations of ovarian damage in women at reproductive age vary from temporary irregular menses to amenorrhea, infertility, and premature ovarian failure depending on the magnitude of the damage. The probability of developing permanent ovarian failure depends on the following factors: patient’s age and the type, dose, and duration of the treatment. If the patient is older and her ovarian reserve is low, they are less likely to retain or regain menstrual function than younger ones. Studies have documented that cyclophosphamide administration is the most significant risk factor for ovarian failure and that AMH is a sensitive and reliable marker of ovarian reserve and damage after exposure to cyclophosphamide in female patients with SLE [106, 107, 108]. In the case of cyclophosphamide administration in lupus patients fertility preservation may be attempted [108]. Currently, embryo or oocyte freezing are the established methods used for fertility preservation in patients receiving gonadotoxic treatment [109, 110, 111]. Other options are ovarian tissue freezing and the use of gonadotropin-releasing (GnRH) hormone agonist treatment concurrently with chemotherapy [112, 113].
In conclusion, the reproductive function of female SLE patients can be adversely affected by various mechanisms such as, the chronic inflammatory state, autoimmune ovarian disease in the form of autoimmune oophoritis, lupus flares associated with hyperprolactinemia, which may interfere with ovulation and may modulate immune activity and temporary or even permanent premature ovarian failure as a result of the administration of cytotoxic agents such as cyclophosphamide.
5. Conclusion
SLE is a systemic autoimmune disease which affects all organ systems and occurs frequently in female patients in the reproductive period. Estrogens appear to modulate the immune response, induce loss of self-tolerance, alter the Th1/Th2 balance in favor of the Th2 process, induce the survival of T and B lymphocytes and the production of autoantibodies. Estrogens appear to be involved in the pathogenesis of SLE. In SLE neuroendocrine system function is affected by the autoimmune process, the neuroendocrine system affecting in turn the disease process. Stress appears to affect disease expression in lupus patients. In SLE hypothyroidism occurs oftener than in the general population, hyperthyroidism occurs in the same rate as in the general population and Hashimoto’s thyroiditis is present oftener than in a control population. Diabetes mellitus 1 occurs sometimes, diabetes mellitus 2 occurs less frequently than in the general population. Hyperparathyroidism has been observed in lupus patients. Addison’s disease is extremely rare in lupus patients. Cushing’s disease occurs infrequently in lupus patients. The ovarian function is affected in female SLE patients. Primary ovarian failure may occur due to autoimmune oophoritis. Cyclophosphamide in SLE is used and its use may be accompanied by the development of premature ovarian failure. The recognition of endocrine disease is important in SLE as symptoms may be similar to those of lupus, however management may be different. The recognition and treatment of an endocrine problem in SLE may guide treatment and lead to symptom amelioration and proper patient management.
\n',keywords:"systemic lupus erythematosus, estrogens, neuroendocrine axis, stress, hypothyroidism, hyperthyroidism, Hashimoto’s thyroiditis, hyperparathyroidism, ovarian function",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/76679.pdf",chapterXML:"https://mts.intechopen.com/source/xml/76679.xml",downloadPdfUrl:"/chapter/pdf-download/76679",previewPdfUrl:"/chapter/pdf-preview/76679",totalDownloads:235,totalViews:0,totalCrossrefCites:0,dateSubmitted:"August 4th 2020",dateReviewed:"March 22nd 2021",datePrePublished:"May 10th 2021",datePublished:"August 25th 2021",dateFinished:"May 10th 2021",readingETA:"0",abstract:"Systemic lupus erythematosus (SLE) is a systemic autoimmune disease affecting all organ systems. It affects primarily female patients in the reproductive age. The disease has a variable course from very mild to severe and may be fatal. It is characterized by exacerbations of disease activity called flares. Estrogens seem to be involved in SLE pathogenesis as they have multiple immunomodulating properties. In SLE the autoimmune process affects the neuroendocrine axis. Stress modulates disease expression in lupus patients. The disease affects the endocrine system. Hypothyroidism occurs in SLE patients in a higher rate than that of the general population. Hyperthyroidism is also observed in SLE, however, in the rate expected for the general population. Hashimoto’s thyroiditis is observed in SLE in a higher rate than that of the general population. Hyperparathyroidism is also observed in SLE, primary and secondary in the context of renal insufficiency due to lupus nephritis. Addison’s disease is rare in SLE. Cushing’s disease due to an adrenal adenoma has been observed, but it is rare. Ovarian function may be compromised in SLE, due to autoimmune oophoritis or drug toxicity. The recognition of endocrine disease in SLE is important as it may guide proper management and symptom amelioration.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/76679",risUrl:"/chapter/ris/76679",signatures:"Ifigenia Kostoglou-Athanassiou, Lambros Athanassiou and Panagiotis Athanassiou",book:{id:"9104",type:"book",title:"Lupus",subtitle:"Need to Know",fullTitle:"Lupus - Need to Know",slug:"lupus-need-to-know",publishedDate:"August 25th 2021",bookSignature:"Reem Hamdy A. Mohammed",coverURL:"https://cdn.intechopen.com/books/images_new/9104.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-405-0",printIsbn:"978-1-83968-403-6",pdfIsbn:"978-1-83968-406-7",isAvailableForWebshopOrdering:!0,editors:[{id:"36290",title:"Prof.",name:"Reem Hamdy A.",middleName:null,surname:"Mohammed",slug:"reem-hamdy-a.-mohammed",fullName:"Reem Hamdy A. Mohammed"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"307495",title:"Dr.",name:"Ifigenia",middleName:null,surname:"Kostoglou-Athanassiou",fullName:"Ifigenia Kostoglou-Athanassiou",slug:"ifigenia-kostoglou-athanassiou",email:"ikostoglouathanassiou@yahoo.gr",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/307495/images/system/307495.jpg",institution:null},{id:"311714",title:"Dr.",name:"Panagiotis",middleName:null,surname:"Athanassiou",fullName:"Panagiotis Athanassiou",slug:"panagiotis-athanassiou",email:"pathanassiou@yahoo.gr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"St. Paul's Hospital",institutionURL:null,country:{name:"Canada"}}},{id:"341181",title:"Dr.",name:"Lambros",middleName:null,surname:"Athanassiou",fullName:"Lambros Athanassiou",slug:"lambros-athanassiou",email:"lambros.ath@yahoo.gr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The neuroendocrine axis in systemic lupus erythematosus",level:"1"},{id:"sec_2_2",title:"2.1 Stress and systemic lupus erythematosus",level:"2"},{id:"sec_3_2",title:"2.2 Estrogens in the pathogenesis of systemic lupus erythematosus",level:"2"},{id:"sec_5",title:"3. Endocrine disorders in systemic lupus erythematosus",level:"1"},{id:"sec_5_2",title:"3.1 Thyroid disease in SLE",level:"2"},{id:"sec_5_3",title:"3.1.1 Hypothyroidism",level:"3"},{id:"sec_6_3",title:"3.1.2 Hyperthyroidism",level:"3"},{id:"sec_7_3",title:"3.1.3 Autoimmune Hashimoto’s thyroiditis",level:"3"},{id:"sec_8_3",title:"3.1.4 Graves’ disease",level:"3"},{id:"sec_10_2",title:"3.2 Pancreatic dysfunction in SLE pathogenesis and form",level:"2"},{id:"sec_10_3",title:"3.2.1 Diabetes mellitus 1",level:"3"},{id:"sec_11_3",title:"3.2.2 Diabetes mellitus 2",level:"3"},{id:"sec_13_2",title:"3.3 Parathyroid disease in SLE",level:"2"},{id:"sec_13_3",title:"3.3.1 Hyperparathyroidism",level:"3"},{id:"sec_15_2",title:"3.4 Adrenal disease in SLE",level:"2"},{id:"sec_15_3",title:"3.4.1 Addison’s disease",level:"3"},{id:"sec_16_3",title:"3.4.2 Cushing’s syndrome",level:"3"},{id:"sec_19",title:"4. Ovarian function",level:"1"},{id:"sec_20",title:"5. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. Sep 2019;78(9):1151-1159. doi:10.1136/annrheumdis-2018-214819'},{id:"B2",body:'Fava A, Petri M. Systemic lupus erythematosus: Diagnosis and clinical management. J Autoimmun. Jan 2019;96:1-13. doi:10.1016/j.jaut.2018.11.001'},{id:"B3",body:'Durcan L, O\'Dwyer T, Petri M. Management strategies and future directions for systemic lupus erythematosus in adults. Lancet. Jun 8 2019;393(10188):2332-2343. doi:10.1016/s0140-6736(19)30237-5'},{id:"B4",body:'Tselios K, Gladman DD, Touma Z, Su J, Anderson N, Urowitz MB. Disease course patterns in systemic lupus erythematosus. Lupus. Jan 2019;28(1):114-122. doi:10.1177/0961203318817132'},{id:"B5",body:'Schäfer VS, Weiß K, Krause A, Schmidt WA. Does erythrocyte sedimentation rate reflect and discriminate flare from infection in systemic lupus erythematosus? Correlation with clinical and laboratory parameters of disease activity. Clin Rheumatol. Jul 2018;37(7):1835-1844. doi:10.1007/s10067-018-4093-3'},{id:"B6",body:'Gergianaki I, Bortoluzzi A, Bertsias G. Update on the epidemiology, risk factors, and disease outcomes of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. Apr 2018;32(2):188-205. doi:10.1016/j.berh.2018.09.004'},{id:"B7",body:'Tipton CM, Hom JR, Fucile CF, Rosenberg AF, Sanz I. Understanding B-cell activation and autoantibody repertoire selection in systemic lupus erythematosus: A B-cell immunomics approach. Immunol Rev. Jul 2018;284(1):120-131. doi:10.1111/imr.12660'},{id:"B8",body:'Yap DYH, Chan TM. B Cell Abnormalities in Systemic Lupus Erythematosus and Lupus Nephritis-Role in Pathogenesis and Effect of Immunosuppressive Treatments. Int J Mol Sci. Dec 10 2019;20(24)doi:10.3390/ijms20246231'},{id:"B9",body:'Ma K, Du W, Wang X, et al. Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus. Int J Mol Sci. Nov 29 2019;20(23)doi:10.3390/ijms20236021'},{id:"B10",body:'Makiyama A, Chiba A, Noto D, et al. Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation. Rheumatology (Oxford). Oct 1 2019;58(10):1861-1869. doi:10.1093/rheumatology/kez077'},{id:"B11",body:'Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). Sep 2003;82(5):299-308. doi:10.1097/01.md.0000091181.93122.55'},{id:"B12",body:'Mistry P, Kaplan MJ. Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis. Clin Immunol. Dec 2017;185:59-73. doi:10.1016/j.clim.2016.08.010'},{id:"B13",body:'Morel L. Immunometabolism in systemic lupus erythematosus. Nat Rev Rheumatol. May 2017;13(5):280-290. doi:10.1038/nrrheum.2017.43'},{id:"B14",body:'Muñoz C, Isenberg DA. Review of major endocrine abnormalities in patients with systemic lupus erythematosus. Clin Exp Rheumatol. Sep-Oct 2019;37(5):791-796'},{id:"B15",body:'Tsokos GC, Lo MS, Costa Reis P, Sullivan KE. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. Nov 22 2016;12(12):716-730. doi:10.1038/nrrheum.2016.186'},{id:"B16",body:'Kalsi JK, Grossman J, Kim J, et al. Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systemic lupus erythematosus: relation of cytokine pattern to disease duration. Lupus. 2004;13(7):490-500. doi:10.1191/0961203303lu1060oa'},{id:"B17",body:'Ashley NT, Demas GE. Neuroendocrine-immune circuits, phenotypes, and interactions. Horm Behav. Jan 2017;87:25-34. doi:10.1016/j.yhbeh.2016.10.004'},{id:"B18",body:'Kim YK, Na KS, Myint AM, Leonard BE. The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuropsychopharmacol Biol Psychiatry. Jan 4 2016;64:277-84. doi:10.1016/j.pnpbp.2015.06.008'},{id:"B19",body:'Tsagarakis S, Gillies G, Rees LH, Besser M, Grossman A. Interleukin-1 directly stimulates the release of corticotrophin releasing factor from rat hypothalamus. Neuroendocrinology. Jan 1989;49(1):98-101. doi:10.1159/000125096'},{id:"B20",body:'Bellavance MA, Rivest S. The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev. Jul 2012;248(1):36-55. doi:10.1111/j.1600-065X.2012.01129.x'},{id:"B21",body:'Turnbull AV, Rivier C. Regulation of the HPA axis by cytokines. Brain Behav Immun. Dec 1995;9(4):253-75. doi:10.1006/brbi.1995.1026'},{id:"B22",body:'Turnbull AV, Rivier CL. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev. Jan 1999;79(1):1-71. doi:10.1152/physrev.1999.79.1.1'},{id:"B23",body:'Silverman MN, Sternberg EM. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann N Y Acad Sci. Jul 2012;1261:55-63. doi:10.1111/j.1749-6632.2012.06633.x'},{id:"B24",body:'Chover-Gonzalez AJ, Jessop DS, Tejedor-Real P, Gibert-Rahola J, Harbuz MS. Onset and severity of inflammation in rats exposed to the learned helplessness paradigm. Rheumatology (Oxford). Jul 2000;39(7):764-71. doi:10.1093/rheumatology/39.7.764'},{id:"B25",body:'Harbuz MS, Chover-Gonzalez AJ, Jessop DS. Hypothalamo-pituitary-adrenal axis and chronic immune activation. Ann N Y Acad Sci. May 2003;992:99-106. doi:10.1111/j.1749-6632.2003.tb03141.x'},{id:"B26",body:'Recalde G, Moreno-Sosa T, Yúdica F, et al. Contribution of sex steroids and prolactin to the modulation of T and B cells during autoimmunity. Autoimmun Rev. May 2018;17(5):504-512. doi:10.1016/j.autrev.2018.03.006'},{id:"B27",body:'Saha S, Tieng A, Pepeljugoski KP, Zandamn-Goddard G, Peeva E. Prolactin, systemic lupus erythematosus, and autoreactive B cells: lessons learnt from murine models. Clin Rev Allergy Immunol. Feb 2011;40(1):8-15. doi:10.1007/s12016-009-8182-6'},{id:"B28",body:'Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin and Autoimmunity. Front Immunol. 2018;9:73. doi:10.3389/fimmu.2018.00073'},{id:"B29",body:'Borba VV, Zandman-Goddard G, Shoenfeld Y. Prolactin and autoimmunity: The hormone as an inflammatory cytokine. Best Pract Res Clin Endocrinol Metab. Dec 2019;33(6):101324. doi:10.1016/j.beem.2019.101324'},{id:"B30",body:'Jacobi AM, Rohde W, Ventz M, Riemekasten G, Burmester GR, Hiepe F. Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity. Lupus. 2001;10(8):554-61. doi:10.1191/096120301701549688'},{id:"B31",body:'Jacobi AM, Rohde W, Volk HD, Dörner T, Burmester GR, Hiepe F. Prolactin enhances the in vitro production of IgG in peripheral blood mononuclear cells from patients with systemic lupus erythematosus but not from healthy controls. Ann Rheum Dis. Mar 2001;60(3):242-7. doi:10.1136/ard.60.3.242'},{id:"B32",body:'Walker SE. Treatment of systemic lupus erythematosus with bromocriptine. Lupus. 2001;10(3):197-202. doi:10.1191/096120301666625458'},{id:"B33",body:'Leite De Moraes MC, Touraine P, Gagnerault MC, Savino W, Kelly PA, Dardenne M. Prolactin receptors and the immune system. Ann Endocrinol (Paris). 1995;56(6):567-70'},{id:"B34",body:'Vera-Lastra O, Jara LJ, Espinoza LR. Prolactin and autoimmunity. Autoimmun Rev. Dec 2002;1(6):360-4. doi:10.1016/s1568-9972(02)00081-2'},{id:"B35",body:'Jara LJ, Medina G, Saavedra MA, et al. Prolactin has a pathogenic role in systemic lupus erythematosus. Immunol Res. Apr 2017;65(2):512-523. doi:10.1007/s12026-016-8891-x'},{id:"B36",body:'Vieira Borba V, Sharif K, Shoenfeld Y. Breastfeeding and autoimmunity: Programing health from the beginning. Am J Reprod Immunol. Jan 2018;79(1)doi:10.1111/aji.12778'},{id:"B37",body:'Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve--an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. Dec 2000;52(4):595-638'},{id:"B38",body:'Sharma D, Farrar JD. Adrenergic regulation of immune cell function and inflammation. Semin Immunopathol. Dec 2020;42(6):709-717. doi:10.1007/s00281-020-00829-6'},{id:"B39",body:'Elenkov IJ, Papanicolaou DA, Wilder RL, Chrousos GP. Modulatory effects of glucocorticoids and catecholamines on human interleukin-12 and interleukin-10 production: clinical implications. Proc Assoc Am Physicians. Sep 1996;108(5):374-81'},{id:"B40",body:'Elenkov IJ, Chrousos GP, Wilder RL. Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implications. Ann N Y Acad Sci. 2000;917:94-105. doi:10.1111/j.1749-6632.2000.tb05374.x'},{id:"B41",body:'Da Costa D, Dobkin PL, Pinard L, et al. The role of stress in functional disability among women with systemic lupus erythematosus: a prospective study. Arthritis Care Res. Apr 1999;12(2):112-9. doi:10.1002/1529-0131(199904)12:2<112::aid-art6>3.0.co;2-2'},{id:"B42",body:'Pawlak CR, Witte T, Heiken H, et al. Flares in patients with systemic lupus erythematosus are associated with daily psychological stress. Psychother Psychosom. May-Jun 2003;72(3):159-65. doi:10.1159/000069735'},{id:"B43",body:'Pawlak CR, Jacobs R, Mikeska E, et al. Patients with systemic lupus erythematosus differ from healthy controls in their immunological response to acute psychological stress. Brain Behav Immun. Dec 1999;13(4):287-302. doi:10.1006/brbi.1999.0553'},{id:"B44",body:'Szyper-Kravitz M, Zandman-Goddard G, Lahita RG, Shoenfeld Y. The neuroendocrine-immune interactions in systemic lupus erythematosus: a basis for understanding disease pathogenesis and complexity. Rheum Dis Clin North Am. Feb 2005;31(1):161-75, x. doi:10.1016/j.rdc.2004.10.004'},{id:"B45",body:'Yasin SA, Costa A, Forsling ML, Grossman A. Interleukin-1 beta and interleukin-6 stimulate neurohypophysial hormone release in vitro. J Neuroendocrinol. Apr 1994;6(2):179-84. doi:10.1111/j.1365-2826.1994.tb00570.x'},{id:"B46",body:'Kostoglou-Athanassiou I, Costa A, Navarra P, Nappi G, Forsling ML, Grossman AB. Endotoxin stimulates an endogenous pathway regulating corticotropin-releasing hormone and vasopressin release involving the generation of nitric oxide and carbon monoxide. Article. Journal of Neuroimmunology. Jun 1998;86(1):104-109. doi:10.1016/s0165-5728(98)00028-9'},{id:"B47",body:'Baraczka K, Nékám K, Pozsonyi T, Szüts I, Ormos G. Investigation of cytokine (tumor necrosis factor-alpha, interleukin-6, interleukin-10) concentrations in the cerebrospinal fluid of female patients with multiple sclerosis and systemic lupus erythematosus. Eur J Neurol. Jan 2004;11(1):37-42. doi:10.1046/j.1351-5101.2003.00706.x'},{id:"B48",body:'Margery-Muir AA, Bundell C, Nelson D, Groth DM, Wetherall JD. Gender balance in patients with systemic lupus erythematosus. Autoimmun Rev. Mar 2017;16(3):258-268. doi:10.1016/j.autrev.2017.01.007'},{id:"B49",body:'Lahita RG. The importance of estrogens in systemic lupus erythematosus. Clin Immunol Immunopathol. Apr 1992;63(1):17-8. doi:10.1016/0090-1229(92)90086-4'},{id:"B50",body:'Cutolo M, Capellino S, Sulli A, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. Nov 2006;1089:538-47. doi:10.1196/annals.1386.043'},{id:"B51",body:'Lahita RG. The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol. Sep 1999;11(5):352-6. doi:10.1097/00002281-199909000-00005'},{id:"B52",body:'Costenbader KH, Feskanich D, Stampfer MJ, Karlson EW. Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum. Apr 2007;56(4):1251-62. doi:10.1002/art.22510'},{id:"B53",body:'Buyon JP, Petri MA, Kim MY, et al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. Jun 21 2005;142(12 Pt 1):953-62. doi:10.7326/0003-4819-142-12_part_1-200506210-00004'},{id:"B54",body:'Scofield RH, Bruner GR, Namjou B, et al. Klinefelter\'s syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum. Aug 2008;58(8):2511-7. doi:10.1002/art.23701'},{id:"B55",body:'Lateef A, Petri M. Systemic Lupus Erythematosus and Pregnancy. Rheum Dis Clin North Am. May 2017;43(2):215-226. doi:10.1016/j.rdc.2016.12.009'},{id:"B56",body:'Eudy AM, Siega-Riz AM, Engel SM, et al. Effect of pregnancy on disease flares in patients with systemic lupus erythematosus. Ann Rheum Dis. Jun 2018;77(6):855-860. doi:10.1136/annrheumdis-2017-212535'},{id:"B57",body:'Stojan G, Baer AN. Flares of systemic lupus erythematosus during pregnancy and the puerperium: prevention, diagnosis and management. Expert Rev Clin Immunol. Jul 2012;8(5):439-53. doi:10.1586/eci.12.36'},{id:"B58",body:'Lourenço EV, La Cava A. Cytokines in systemic lupus erythematosus. Curr Mol Med. Apr 2009;9(3):242-54. doi:10.2174/156652409787847263'},{id:"B59",body:'Luo CY, Wang L, Sun C, Li DJ. Estrogen enhances the functions of CD4(+)CD25(+)Foxp3(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro. Cell Mol Immunol. Jan 2011;8(1):50-8. doi:10.1038/cmi.2010.54'},{id:"B60",body:'Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today. Jan 1995;16(1):34-8. doi:10.1016/0167-5699(95)80068-9'},{id:"B61",body:'Constant SL, Bottomly K. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol. 1997;15:297-322. doi:10.1146/annurev.immunol.15.1.297'},{id:"B62",body:'Street NE, Mosmann TR. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. Faseb j. Feb 1991;5(2):171-7. doi:10.1096/fasebj.5.2.1825981'},{id:"B63",body:'Kanda N, Tsuchida T, Tamaki K. Estrogen enhancement of anti-double-stranded DNA antibody and immunoglobulin G production in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum. Feb 1999;42(2):328-37. doi:10.1002/1529-0131(199902)42:2<328::aid-anr16>3.0.co;2-#'},{id:"B64",body:'Kim WU, Min SY, Hwang SH, Yoo SA, Kim KJ, Cho CS. Effect of oestrogen on T cell apoptosis in patients with systemic lupus erythematosus. Clin Exp Immunol. Sep 2010;161(3):453-8. doi:10.1111/j.1365-2249.2010.04194.x'},{id:"B65",body:'Polanczyk MJ, Hopke C, Vandenbark AA, Offner H. Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway. J Neurosci Res. Aug 1 2006;84(2):370-8. doi:10.1002/jnr.20881'},{id:"B66",body:'Seto K, Hoang M, Santos T, Bandyopadhyay M, Kindy MS, Dasgupta S. Non-genomic oestrogen receptor signal in B lymphocytes: An approach towards therapeutic interventions for infection, autoimmunity and cancer. Int J Biochem Cell Biol. Jul 2016;76:115-8. doi:10.1016/j.biocel.2016.04.018'},{id:"B67",body:'Liao ZH, Huang T, Xiao JW, et al. Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells. Skelet Muscle. Jul 29 2019;9(1):20. doi:10.1186/s13395-019-0205-2'},{id:"B68",body:'Ong SG, Choy CH. Autoimmune thyroid disease in a cohort of Malaysian SLE patients: frequency, clinical and immunological associations. Lupus. Jan 2016;25(1):67-74. doi:10.1177/0961203315593164'},{id:"B69",body:'Antonelli A, Fallahi P, Mosca M, et al. Prevalence of thyroid dysfunctions in systemic lupus erythematosus. Metabolism. Jun 2010;59(6):896-900. doi:10.1016/j.metabol.2009.10.010'},{id:"B70",body:'Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis. Jan 2002;61(1):70-2. doi:10.1136/ard.61.1.70'},{id:"B71",body:'Vanderpump MP. The epidemiology of thyroid disease. Br Med Bull. 2011;99:39-51. doi:10.1093/bmb/ldr030'},{id:"B72",body:'Watad A, Mahroum N, Whitby A, et al. Hypothyroidism among SLE patients: Case-control study. Autoimmun Rev. May 2016;15(5):484-6. doi:10.1016/j.autrev.2016.01.019'},{id:"B73",body:'Chan AT, Al-Saffar Z, Bucknall RC. Thyroid disease in systemic lupus erythematosus and rheumatoid arthritis. Rheumatology (Oxford). Mar 2001;40(3):353-4. doi:10.1093/rheumatology/40.3.353'},{id:"B74",body:'Posselt RT, Coelho VN, Skare TL. Hashimoto thyroiditis, anti-thyroid antibodies and systemic lupus erythematosus. Int J Rheum Dis. Jan 2018;21(1):186-193. doi:10.1111/1756-185x.13089'},{id:"B75",body:'Liu H, Yang LH, Yin G, Xie QB. [Correlation of Thyroid Autoantibodies,System Lupus Erythematosus Immunologic Indicators and Disease Activity in SLE with HT]. Sichuan Da Xue Xue Bao Yi Xue Ban. Mar 2018;49(2):179-182'},{id:"B76",body:'Tan B, Yuan W, Li J, et al. Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto\'s thyroiditis and Systemic lupus erythematosus. Cytotherapy. Oct 2018;20(10):1247-1258. doi:10.1016/j.jcyt.2018.04.001'},{id:"B77",body:'Smith TJ, Hegedüs L. Graves\' Disease. N Engl J Med. Oct 20 2016;375(16):1552-1565. doi:10.1056/NEJMra1510030'},{id:"B78",body:'Ferrari SM, Elia G, Virili C, Centanni M, Antonelli A, Fallahi P. Systemic Lupus Erythematosus and Thyroid Autoimmunity. Front Endocrinol (Lausanne). 2017;8:138. doi:10.3389/fendo.2017.00138'},{id:"B79",body:'Zhanga Y, Xiaoa X, Haoa Q , Lia X, Renb J, Hu Z. The onset of systemic lupus erythematosus and thyroid dysfunction following Graves’ disease – A case report and literature review. Srp Arh Celok Lek. Nov-Dec 2016;144(11-12):639-44. doi:10.2298/sarh1612639z'},{id:"B80",body:'Cortes S, Chambers S, Jerónimo A, Isenberg D. Diabetes mellitus complicating systemic lupus erythematosus - analysis of the UCL lupus cohort and review of the literature. Lupus. Nov 2008;17(11):977-80. doi:10.1177/0961203308091539'},{id:"B81",body:'Zeglaoui H, Landolsi H, Mankai A, Ghedira I, Bouajina E. Type 1 diabetes mellitus, celiac disease, systemic lupus erythematosus and systemic scleroderma in a 15-year-old girl. Rheumatol Int. Apr 2010;30(6):793-5. doi:10.1007/s00296-009-0988-2'},{id:"B82",body:'Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014;11(11):1185-200. doi:10.7150/ijms.10001'},{id:"B83",body:'Dong Y, Dai Z, Wang Z, et al. Risk of gestational diabetes mellitus in systemic lupus erythematosus pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth. May 22 2019;19(1):179. doi:10.1186/s12884-019-2329-0'},{id:"B84",body:'Galrão LD, Lima IV, Santos L, Santiago MB. [Primary hyperparathyroidism in a patient with systemic lupus erythematosus]. Arq Bras Endocrinol Metabol. Aug 2004;48(4):555-8. Hiperparatireoidismo primário em paciente com lúpus eritematoso sistêmico. doi:10.1590/s0004-27302004000400017'},{id:"B85",body:'Jiang J, Zhang M, He R, Shen M, Liu W. Functional parathyroid cyst in a patient with systemic lupus erythematosus: a case report. Endocrinol Diabetes Metab Case Rep. 2015;2015:140100. doi:10.1530/edm-14-0100'},{id:"B86",body:'Godswill OC, Odigie OO. Primary Adrenal Insufficiency (Addison\'s Disease) Associated with Systemic Lupus Erythematosus: A Rare Occurrence. Int J Prev Med. 2014:1324-7. vol. 10'},{id:"B87",body:'Nakayama Y, Taura D, Shibue K, Kuramoto N, Mimori T, Inagaki N. A case of systemic lupus erythematosus complicated by subclinical Cushing\'s syndrome: case report. Mod Rheumatol Case Rep. Jan 2020;4(1):16-20. doi:10.1080/24725625.2019.1638049'},{id:"B88",body:'Shimizu M, Kawata M, Okada T, et al. Concomitant Cushing\'s syndrome due to adrenal adenoma in a patient with systemic lupus erythematosus. Intern Med. Nov 2002;41(11):1044-6. doi:10.2169/internalmedicine.41.1044'},{id:"B89",body:'Oktem O, Guzel Y, Aksoy S, Aydin E, Urman B. Ovarian function and reproductive outcomes of female patients with systemic lupus erythematosus and the strategies to preserve their fertility. Obstet Gynecol Surv. Mar 2015;70(3):196-210. doi:10.1097/ogx.0000000000000160'},{id:"B90",body:'Medeiros PB, Febrônio MV, Bonfá E, Borba EF, Takiuti AD, Silva CA. Menstrual and hormonal alterations in juvenile systemic lupus erythematosus. Lupus. Jan 2009;18(1):38-43. doi:10.1177/0961203308094652'},{id:"B91",body:'Lawrenz B, Henes J, Henes M, et al. Impact of systemic lupus erythematosus on ovarian reserve in premenopausal women: evaluation by using anti-Muellerian hormone. Lupus. Oct 2011;20(11):1193-7. doi:10.1177/0961203311409272'},{id:"B92",body:'LaBarbera AR, Miller MM, Ober C, Rebar RW. Autoimmune etiology in premature ovarian failure. Am J Reprod Immunol Microbiol. Mar 1988;16(3):115-22. doi:10.1111/j.1600-0897.1988.tb00180.x'},{id:"B93",body:'Chang YS, Lai CC, Chen WS, Wang SH, Chou CT, Tsai CY. Protein-losing enteropathy and premature ovarian failure in a young woman with systemic lupus erythematosus. Lupus. Oct 2012;21(11):1237-9. doi:10.1177/0961203312449492'},{id:"B94",body:'Pasoto SG, Viana VS, Mendonca BB, Yoshinari NH, Bonfa E. Anti-corpus luteum antibody: a novel serological marker for ovarian dysfunction in systemic lupus erythematosus? J Rheumatol. May 1999;26(5):1087-93'},{id:"B95",body:'Shabanova SS, Ananieva LP, Alekberova ZS, Guzov, II. Ovarian function and disease activity in patients with systemic lupus erythematosus. Clin Exp Rheumatol. May-Jun 2008;26(3):436-41'},{id:"B96",body:'Joob B, Wiwanitkit V. Prolactin and systemic lupus erythematosus. Immunol Res. 2017:975. vol. 4'},{id:"B97",body:'Song GG, Lee YH. Circulating prolactin level in systemic lupus erythematosus and its correlation with disease activity: a meta-analysis. Lupus. Oct 2017;26(12):1260-1268. doi:10.1177/0961203317693094'},{id:"B98",body:'Nusbaum JS, Mirza I, Shum J, et al. Sex Differences in Systemic Lupus Erythematosus: Epidemiology, Clinical Considerations, and Disease Pathogenesis. Mayo Clin Proc. Feb 2020;95(2):384-394. doi:10.1016/j.mayocp.2019.09.012'},{id:"B99",body:'Petri M. Cyclophosphamide: new approaches for systemic lupus erythematosus. Lupus. 2004;13(5):366-71. doi:10.1191/0961203303lu1028oa'},{id:"B100",body:'Kado R, McCune WJ. Ovarian protection with gonadotropin-releasing hormone agonists during cyclophosphamide therapy in systemic lupus erythematosus. Best Pract Res Clin Obstet Gynaecol. Apr 2020;64:97-106. doi:10.1016/j.bpobgyn.2019.10.008'},{id:"B101",body:'Spears N, Lopes F, Stefansdottir A, et al. Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update. Nov 5 2019;25(6):673-693. doi:10.1093/humupd/dmz027'},{id:"B102",body:'Luan Y, Edmonds ME, Woodruff TK, Kim SY. Inhibitors of apoptosis protect the ovarian reserve from cyclophosphamide. J Endocrinol. Feb 1 2019;240(2):243-256. doi:10.1530/joe-18-0370'},{id:"B103",body:'Xiong Y, Liu T, Wang S, Chi H, Chen C, Zheng J. Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway. Gene. Jan 5 2017;596:1-8. doi:10.1016/j.gene.2016.10.011'},{id:"B104",body:'Harward LE, Mitchell K, Pieper C, Copland S, Criscione-Schreiber LG, Clowse ME. The impact of cyclophosphamide on menstruation and pregnancy in women with rheumatologic disease. Lupus. Jan 2013;22(1):81-6. doi:10.1177/0961203312468624'},{id:"B105",body:'Chemaitilly W, Mertens AC, Mitby P, et al. Acute ovarian failure in the childhood cancer survivor study. J Clin Endocrinol Metab. May 2006;91(5):1723-8. doi:10.1210/jc.2006-0020'},{id:"B106",body:'Mok CC, Chan PT, To CH. Anti-müllerian hormone and ovarian reserve in systemic lupus erythematosus. Arthritis Rheum. Jan 2013;65(1):206-10. doi:10.1002/art.37719'},{id:"B107",body:'Appenzeller S, Blatyta PF, Costallat LT. Ovarian failure in SLE patients using pulse cyclophosphamide: comparison of different regimes. Rheumatol Int. Apr 2008;28(6):567-71. doi:10.1007/s00296-007-0478-3'},{id:"B108",body:'Mersereau J, Dooley MA. Gonadal failure with cyclophosphamide therapy for lupus nephritis: advances in fertility preservation. Rheum Dis Clin North Am. Feb 2010;36(1):99-108, viii. doi:10.1016/j.rdc.2009.12.010'},{id:"B109",body:'Rienzi L, Gracia C, Maggiulli R, et al. Oocyte, embryo and blastocyst cryopreservation in ART: systematic review and meta-analysis comparing slow-freezing versus vitrification to produce evidence for the development of global guidance. Hum Reprod Update. Mar 1 2017;23(2):139-155. doi:10.1093/humupd/dmw038'},{id:"B110",body:'Rajabi Z, Aliakbari F, Yazdekhasti H. Female Fertility Preservation, Clinical and Experimental Options. J Reprod Infertil. Jul-Sep 2018;19(3):125-132'},{id:"B111",body:'Levi-Setti PE, Patrizio P, Scaravelli G. Evolution of human oocyte cryopreservation: slow freezing versus vitrification. Curr Opin Endocrinol Diabetes Obes. Dec 2016;23(6):445-450. doi:10.1097/med.0000000000000289'},{id:"B112",body:'Yding Andersen C, Mamsen LS, Kristensen SG. FERTILITY PRESERVATION: Freezing of ovarian tissue and clinical opportunities. Reproduction. Nov 2019;158(5):F27-f34. doi:10.1530/rep-18-0635'},{id:"B113",body:'Del Mastro L, Lambertini M. Temporary Ovarian Suppression With Gonadotropin-Releasing Hormone Agonist During Chemotherapy for Fertility Preservation: Toward the End of the Debate? Oncologist. Nov 2015;20(11):1233-5. doi:10.1634/theoncologist.2015-0373'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Ifigenia Kostoglou-Athanassiou",address:"ikostoglouathanassiou@yahoo.gr",affiliation:'
Department of Endocrinology, Asclepeion Hospital, Voula, Greece
Department of Rheumatology, St. Paul’s Hospital, Greece
'}],corrections:null},book:{id:"9104",type:"book",title:"Lupus",subtitle:"Need to Know",fullTitle:"Lupus - Need to Know",slug:"lupus-need-to-know",publishedDate:"August 25th 2021",bookSignature:"Reem Hamdy A. Mohammed",coverURL:"https://cdn.intechopen.com/books/images_new/9104.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83968-405-0",printIsbn:"978-1-83968-403-6",pdfIsbn:"978-1-83968-406-7",isAvailableForWebshopOrdering:!0,editors:[{id:"36290",title:"Prof.",name:"Reem Hamdy A.",middleName:null,surname:"Mohammed",slug:"reem-hamdy-a.-mohammed",fullName:"Reem Hamdy A. Mohammed"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},profile:{item:{id:"188395",title:"Dr.",name:"Koldo",middleName:null,surname:"Osoro",email:"kosoro@serida.org",fullName:"Koldo Osoro",slug:"koldo-osoro",position:null,biography:null,institutionString:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",totalCites:0,totalChapterViews:"0",outsideEditionCount:0,totalAuthoredChapters:"1",totalEditedBooks:"0",personalWebsiteURL:null,twitterURL:null,linkedinURL:null,institution:{name:"Servicio Regional de Investigación y Desarrollo Agroalimentario",institutionURL:null,country:{name:"Spain"}}},booksEdited:[],chaptersAuthored:[{id:"54016",title:"Utilization of Biomarkers to Study the Grazing Behavior of Herbivore Species",slug:"utilization-of-biomarkers-to-study-the-grazing-behavior-of-herbivore-species",abstract:"Knowledge on diet selection of different herbivore species under each specific vegetation community is essential to develop and apply appropriate management decisions for each grazing system in order to, simultaneously, have a more efficient and sustainable utilization of pasture resources and the best animal performance level. In this chapter, traditional and more recent methodologies that can be used for studying diet selection of both domestic and wild herbivores are briefly presented, identifying the main advantages and limitations of their use. Particular emphasis is given to the utilization of epicuticular compounds, namely alkanes, long-chain fatty acids and long-chain alcohols, as faecal markers. The validation of their use is presented taking into account studies performed with different animal species under controlled conditions. The main advantages and shortcomings for their application to field studies with grazing animals are highlighted. Data indicate that the combination of these epicuticular compounds seems promising to overcome the enumerated constraints, allowing its application to more complex vegetation communities.",signatures:"Luis Miguel Mendes Ferreira, Rafael Celaya, Ana Sofia Santos, Koldo\nOsoro and Miguel Rodrigues",authors:[{id:"188380",title:"Prof.",name:"Luis",surname:"Ferreira",fullName:"Luis Ferreira",slug:"luis-ferreira",email:"lmf@utad.pt"},{id:"188390",title:"Dr.",name:"Rafa",surname:"Celaya",fullName:"Rafa Celaya",slug:"rafa-celaya",email:"rcelaya@serida.org"},{id:"188392",title:"Prof.",name:"Ana",surname:"Santos",fullName:"Ana Santos",slug:"ana-santos",email:"anasofiasantos@euvg.pt"},{id:"188394",title:"Prof.",name:"Miguel",surname:"Rodrigues",fullName:"Miguel Rodrigues",slug:"miguel-rodrigues",email:"mrodrigu@utad.pt"},{id:"188395",title:"Dr.",name:"Koldo",surname:"Osoro",fullName:"Koldo Osoro",slug:"koldo-osoro",email:"kosoro@serida.org"}],book:{id:"5385",title:"Herbivores",slug:"herbivores",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"183481",title:"Dr.",name:"WenZhu",surname:"Yang",slug:"wenzhu-yang",fullName:"WenZhu Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Agriculture and Agriculture-Food Canada",institutionURL:null,country:{name:"Canada"}}},{id:"186945",title:"Associate Prof.",name:"Jane",surname:"Williamson",slug:"jane-williamson",fullName:"Jane Williamson",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186945/images/4786_n.jpg",biography:null,institutionString:null,institution:{name:"Macquarie University",institutionURL:null,country:{name:"Australia"}}},{id:"187820",title:"Ms.",name:"Carolina",surname:"Pietczak",slug:"carolina-pietczak",fullName:"Carolina Pietczak",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Federal Farroupilha",institutionURL:null,country:{name:"Brazil"}}},{id:"187826",title:"Dr.",name:"Jacqueline",surname:"Bell",slug:"jacqueline-bell",fullName:"Jacqueline Bell",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Macquarie University",institutionURL:null,country:{name:"Australia"}}},{id:"187846",title:"Dr.",name:"Alina",surname:"Morquecho-Contreras",slug:"alina-morquecho-contreras",fullName:"Alina Morquecho-Contreras",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},{id:"188013",title:"Ph.D. Student",name:"Khalil",surname:"Safaei",slug:"khalil-safaei",fullName:"Khalil Safaei",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Malayer University",institutionURL:null,country:{name:"Iran"}}},{id:"188514",title:"Prof.",name:"Ute",surname:"Wittstock",slug:"ute-wittstock",fullName:"Ute Wittstock",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Braunschweig University of Technology",institutionURL:null,country:{name:"Germany"}}},{id:"194230",title:"Dr.",name:"Maike",surname:"van Ohlen",slug:"maike-van-ohlen",fullName:"Maike van Ohlen",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"194580",title:"MSc.",name:"Lucas",surname:"Vieira",slug:"lucas-vieira",fullName:"Lucas Vieira",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Instituto Federal Catarinense",institutionURL:null,country:{name:"Brazil"}}},{id:"194934",title:"Dr.",name:"Anna-Maria",surname:"Herfurth",slug:"anna-maria-herfurth",fullName:"Anna-Maria Herfurth",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null}]},generic:{page:{slug:"access-policy",title:"Access policy",intro:"
IntechOpen books and journals are available online by accessing all published content on a chapter/article level.
",metaTitle:"Access policy",metaDescription:"IntechOpen books are available online by accessing all published content on a chapter level",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"
All IntechOpen published chapters and articles are available OPEN ACCESS and can be read without the requirement for registration of any kind, immediately upon publication, without any barrier.
\\n\\n
The HTML version, as well as the PDF version of publications dated before 2012 that are accessible through a reader, are available to readers with no restriction.
\\n\\n
The full content of chapters and articles can be read, copied and printed from the link location of the chapter/article and these actions are not limited or restricted in any way.
\\n\\n
Registration is requested only to download the PDF of the chapter/article. There are no subscription fees and there is no charge to user groups.
\\n\\n
IntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
\\n\\n
Authors may post published works to any repository or website with no delay, and Authors and Editors of IntechOpen books have direct access to the PDF of the full book.
\\n\\n
All published content can be crawled for indexing. Full text and metadata may be accessed with instructions publicly posted.
\\n\\n
All IntechOpen books and Journal articles are indexed in CLOCKSS and preservation of access to published content is clearly indicated.
All IntechOpen published chapters and articles are available OPEN ACCESS and can be read without the requirement for registration of any kind, immediately upon publication, without any barrier.
\n\n
The HTML version, as well as the PDF version of publications dated before 2012 that are accessible through a reader, are available to readers with no restriction.
\n\n
The full content of chapters and articles can be read, copied and printed from the link location of the chapter/article and these actions are not limited or restricted in any way.
\n\n
Registration is requested only to download the PDF of the chapter/article. There are no subscription fees and there is no charge to user groups.
\n\n
IntechOpen chapters and articles are distributed under CC BY 3.0 licences allowing users to “copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship...” and there is no non-commercial restriction.
\n\n
Authors may post published works to any repository or website with no delay, and Authors and Editors of IntechOpen books have direct access to the PDF of the full book.
\n\n
All published content can be crawled for indexing. Full text and metadata may be accessed with instructions publicly posted.
\n\n
All IntechOpen books and Journal articles are indexed in CLOCKSS and preservation of access to published content is clearly indicated.
\n\n
Policy last updated: 2022-04-14
\n"}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13388},{group:"region",caption:"Middle and South America",value:2,count:11658},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33638}],offset:12,limit:12,total:135272},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{sort:"-dateEndThirdStepPublish",topicId:"9"},books:[{type:"book",id:"12063",title:"Critical Infrastructure - Modern Approach and New Developments",subtitle:null,isOpenForSubmission:!0,hash:"a88b0006f3a58c0a60f89e06efb31102",slug:null,bookSignature:"Dr. Antonio Di Pietro and Prof. Jose Marti",coverURL:"https://cdn.intechopen.com/books/images_new/12063.jpg",editedByType:null,editors:[{id:"284589",title:"Dr.",name:"Antonio",surname:"Di Pietro",slug:"antonio-di-pietro",fullName:"Antonio Di Pietro"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11447",title:"Swarm Intelligence - Recent Advances and Current Applications",subtitle:null,isOpenForSubmission:!0,hash:"f68e3c3430a74fc7a7eb97f6ea2bb42e",slug:null,bookSignature:"Dr. Marco Antonio Aceves Fernandez",coverURL:"https://cdn.intechopen.com/books/images_new/11447.jpg",editedByType:null,editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12072",title:"Finite Element Method and Its Extensions",subtitle:null,isOpenForSubmission:!0,hash:"3b9656ca1f591fcc44f127e12a6ef28f",slug:null,bookSignature:"Prof. Mahboub Baccouch",coverURL:"https://cdn.intechopen.com/books/images_new/12072.jpg",editedByType:null,editors:[{id:"186635",title:"Prof.",name:"Mahboub",surname:"Baccouch",slug:"mahboub-baccouch",fullName:"Mahboub Baccouch"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11917",title:"Computational Semantics",subtitle:null,isOpenForSubmission:!0,hash:"eaaeec44e8fe5d1c9237fef5e0df8931",slug:null,bookSignature:"Prof. George Dekoulis",coverURL:"https://cdn.intechopen.com/books/images_new/11917.jpg",editedByType:null,editors:[{id:"9833",title:"Prof.",name:"George",surname:"Dekoulis",slug:"george-dekoulis",fullName:"George Dekoulis"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12281",title:"Malware - Detection and Defense",subtitle:null,isOpenForSubmission:!0,hash:"41d18e9dcc5743bc6c8ae7403acb20a7",slug:null,bookSignature:"Prof. Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/12281.jpg",editedByType:null,editors:[{id:"10086",title:"Prof.",name:"Eduard",surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"12068",title:"Advances in Virtual Reality",subtitle:null,isOpenForSubmission:!0,hash:"4a0ea50f2deff672ee70f21251121955",slug:null,bookSignature:"Dr. Mamata Rath and Dr. Vijayakumar Varadarajan",coverURL:"https://cdn.intechopen.com/books/images_new/12068.jpg",editedByType:null,editors:[{id:"474611",title:"Dr.",name:"Dr.Mamata",surname:"Rath",slug:"dr.mamata-rath",fullName:"Dr.Mamata Rath"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11911",title:"Scientometrics - Evolution, Methods, and Applications in Research",subtitle:null,isOpenForSubmission:!0,hash:"21cabdc221ee3c4ce67965075c22211f",slug:null,bookSignature:"Dr. Mohan Bairwa, Dr. M. Mahbub Hossain, Dr. Neeraj Sharma and Dr. Manju Pilania",coverURL:"https://cdn.intechopen.com/books/images_new/11911.jpg",editedByType:null,editors:[{id:"181864",title:"Dr.",name:"Mohan",surname:"Bairwa",slug:"mohan-bairwa",fullName:"Mohan Bairwa"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11919",title:"SQL Programming in Practice",subtitle:null,isOpenForSubmission:!0,hash:"d1d908cd61561c1e813552fbd6cb9ed1",slug:null,bookSignature:"Ph.D. Duc-Man Nguyen and Dr. Van-Loi Nguyen",coverURL:"https://cdn.intechopen.com/books/images_new/11919.jpg",editedByType:null,editors:[{id:"227628",title:"Ph.D.",name:"Duc-Man",surname:"Nguyen",slug:"duc-man-nguyen",fullName:"Duc-Man Nguyen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11554",title:"Information Systems Management",subtitle:null,isOpenForSubmission:!0,hash:"f9b559ad26f909f0423ba9d111663218",slug:null,bookSignature:"Dr. Rohit Raja",coverURL:"https://cdn.intechopen.com/books/images_new/11554.jpg",editedByType:null,editors:[{id:"267434",title:"Dr.",name:"Rohit",surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11547",title:"Information Security and Privacy in the Digital World - Some Selected Topics",subtitle:null,isOpenForSubmission:!0,hash:"b268e581d5e458cb91b82c518f2717eb",slug:null,bookSignature:"Prof. Jaydip Sen",coverURL:"https://cdn.intechopen.com/books/images_new/11547.jpg",editedByType:null,editors:[{id:"4519",title:"Prof.",name:"Jaydip",surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11916",title:"The E-commerce Era",subtitle:null,isOpenForSubmission:!0,hash:"97b6de623f15598880112f6bafedc3e1",slug:null,bookSignature:"Dr. Robert M.X. Wu",coverURL:"https://cdn.intechopen.com/books/images_new/11916.jpg",editedByType:null,editors:[{id:"190913",title:"Dr.",name:"Robert M.X.",surname:"Wu",slug:"robert-m.x.-wu",fullName:"Robert M.X. Wu"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11913",title:"Scheduling Algorithms for Information and Communication Systems",subtitle:null,isOpenForSubmission:!0,hash:"51b9b6eb5e1f6fd01c84879bc8182486",slug:null,bookSignature:"Dr. Yann H. Chemin",coverURL:"https://cdn.intechopen.com/books/images_new/11913.jpg",editedByType:null,editors:[{id:"270578",title:"Dr.",name:"Yann",surname:"Chemin",slug:"yann-chemin",fullName:"Yann Chemin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:28},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:8},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:17},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:45},{group:"topic",caption:"Environmental Sciences",value:12,count:6},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:17},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:74},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:3},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:6},{group:"topic",caption:"Physics",value:20,count:6},{group:"topic",caption:"Psychology",value:21,count:6},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:25},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4805},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7107,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1955,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1452,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2289,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"11263",title:"Supply Chain",subtitle:"Recent Advances and New Perspectives in the Industry 4.0 Era",isOpenForSubmission:!1,hash:"aab634c9c1f9a692c1e9881d18e9c9b7",slug:"supply-chain-recent-advances-and-new-perspectives-in-the-industry-4-0-era",bookSignature:"Tamás Bányai, Ágota Bányai and Ireneusz Kaczmar",coverURL:"https://cdn.intechopen.com/books/images_new/11263.jpg",publishedDate:"July 27th 2022",numberOfDownloads:888,editors:[{id:"201248",title:"Dr.",name:"Tamás",middleName:null,surname:"Bányai",slug:"tamas-banyai",fullName:"Tamás Bányai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1566,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2054,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",publishedDate:"July 27th 2022",numberOfDownloads:780,editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318480,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271760,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1317",title:"Public Health",slug:"social-sciences-education-public-health",parent:{id:"265",title:"Education",slug:"social-sciences-education"},numberOfBooks:2,numberOfSeries:0,numberOfAuthorsAndEditors:14,numberOfWosCitations:1,numberOfCrossrefCitations:12,numberOfDimensionsCitations:18,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"1317",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"10191",title:"Health and Academic Achievement",subtitle:"New Findings",isOpenForSubmission:!1,hash:"7ee3f57e3911318305ac5c2eef39f8ab",slug:"health-and-academic-achievement-new-findings",bookSignature:"Blandina Bernal-Morales",coverURL:"https://cdn.intechopen.com/books/images_new/10191.jpg",editedByType:"Edited by",editors:[{id:"174721",title:"Dr.",name:"Blandina",middleName:null,surname:"Bernal-Morales",slug:"blandina-bernal-morales",fullName:"Blandina Bernal-Morales"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8645",title:"Contemporary Topics in Graduate Medical Education",subtitle:null,isOpenForSubmission:!1,hash:"76d224ba3c158c43fda8141a61ababd6",slug:"contemporary-topics-in-graduate-medical-education",bookSignature:"Stanislaw P. Stawicki, Michael S. Firstenberg, James P. Orlando and Thomas J. Papadimos",coverURL:"https://cdn.intechopen.com/books/images_new/8645.jpg",editedByType:"Edited by",editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:2,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"66759",doi:"10.5772/intechopen.84235",title:"Resident Autonomy",slug:"resident-autonomy",totalDownloads:923,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Autonomy in medical training is required to develop independent and competent physicians. The way in which this incremental level of independence is granted to a trainee must be thoughtful and deliberate to ensure appropriate supervision and patient safety. Theories that support the role of autonomy will be introduced and discussed in this chapter. Ethical considerations that describe the implications of balancing the necessary independence for trainees and an attending physician’s responsibility to the patient and the patient’s safety will also be considered. The level of autonomy that is granted is the responsibility of both the attending physician and trainee so that it is not only appropriate but also well-earned. There are multiple tools that may be used to objectively measure one’s competence and necessary level of autonomy based on performance that will be discussed within this chapter. Finally we will demonstrate that encouraging and striking the balance of supervision and autonomy may be done safely with appropriate patient outcomes and trainee development into independent physicians. These outcomes will help to encourage autonomy amongst medical trainees, no matter one’s specialty, to train and develop competent, independent physicians of the future.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Amanda Cooper and Steven Allen",authors:null},{id:"73295",doi:"10.5772/intechopen.93886",title:"The Social Isolation Triggered by COVID-19: Effects on Mental Health and Education in Mexico",slug:"the-social-isolation-triggered-by-covid-19-effects-on-mental-health-and-education-in-mexico",totalDownloads:766,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Public health in Mexico was on alert since the World Health Organization declared a pandemic of COVID-19. This disease represents a challenge not only for the health system but also for the education system, which implement emerging measures such as online education. In Mexico online education has several limitations associated with computer and internet access, which affect the academic achievement of the students. Additionally, the main measures against the pandemic are social isolation, but this measure can generate stress and affect the academic achievement and mental health of the population. The present review was based on Mexican scientific and journalistic sources, and a thesaurus system such as Medical Subject Headings (MeSH) terms to find original articles to social isolation, mental health, and academic achievement. The contribution of this chapter is to describe the effects that social isolation has caused on mental health and scholar challenges in the Mexican student population.",book:{id:"10191",slug:"health-and-academic-achievement-new-findings",title:"Health and Academic Achievement",fullTitle:"Health and Academic Achievement - New Findings"},signatures:"Ana Karen Limón-Vázquez, Gabriel Guillén-Ruiz and Emma Virginia Herrera-Huerta",authors:[{id:"218681",title:"Dr.",name:"Gabriel",middleName:null,surname:"Guillén-Ruiz",slug:"gabriel-guillen-ruiz",fullName:"Gabriel Guillén-Ruiz"},{id:"306437",title:"Dr.",name:"Emma Virgina",middleName:null,surname:"Herrera-Huerta",slug:"emma-virgina-herrera-huerta",fullName:"Emma Virgina Herrera-Huerta"},{id:"306438",title:"MSc.",name:"Ana Karen",middleName:null,surname:"Limón-Vázquez",slug:"ana-karen-limon-vazquez",fullName:"Ana Karen Limón-Vázquez"}]},{id:"64635",doi:"10.5772/intechopen.82343",title:"Wellness in Residency: A Paradigm Shift",slug:"wellness-in-residency-a-paradigm-shift",totalDownloads:842,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"There has been a cultural shift in the state of residency training over the past two decades. While the traditional view of trainees heavily emphasized the service component of residency, training programs are gaining an increasing awareness of the trainees’ well-being as crucial to their functioning, the success of the training program, and ultimately, to the care of patients. To this end, work-hour limitations have been imposed universally. Additionally, some programs have established interventions that allow residents to lead balanced lives with emphasis on time away from work, sleep, and outside activities. A paradigm shift recognizing the importance of wellness in residency may reduce the risk of physician burnout in the long term.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Roderick M. Quiros and Elspeth Black",authors:null},{id:"64979",doi:"10.5772/intechopen.82618",title:"Teaching Balanced Patient Care Using Principles of Reductionism and Holism: The Example of Chronic Low Back Pain",slug:"teaching-balanced-patient-care-using-principles-of-reductionism-and-holism-the-example-of-chronic-lo",totalDownloads:1021,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"This chapter explores how integrating holistic and reductionistic approaches to care may better optimize value based care. First, we define the terms ‘Holistic,’ ‘Reductionistic’ and ‘Integrative’. Then we explore their scope in the arenas of teaching and patient care, with the advantages, disadvantages and pitfalls of each approach. We review how these styles are embedded in and interact with the cultures of medicine and western societies at large. As an example of a balanced care approach, we focus on the example of chronic low back pain (CLBP), an increasingly common and expensive medical problem. We present practical examples of teaching and practicing these different styles, Holism and Reductionism, illustrating when each may be appropriate to optimize value of patient care. Study questions are included. A list of further readings and resources is included for the interested reader.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Alan Remde, Stephen DeTurk and Thomas Wojda",authors:null},{id:"63925",doi:"10.5772/intechopen.81532",title:"Curriculum Development: Foundations and Modern Advances in Graduate Medical Education",slug:"curriculum-development-foundations-and-modern-advances-in-graduate-medical-education",totalDownloads:2336,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Curriculum development has undergone many transitions since the inception of medical education in the United States in the 1800’s. In this chapter, we briefly review the history of curriculum development in medical education. We discuss the landmark models of curriculum development including the concept of a curriculum map and Harden’s SPICES model of educational strategy, detail the six steps of Kern’s foundational framework, and provide an overview of the PRISMS strategy. We address the importance of adult learning theory and the advancing understanding of education for the millennial generation, including implementation of the flipped classroom model of education. Finally, we turn our focus on contemporary applications of curriculum design, including the application of simulation to medical education, the rise of massive open online courses (MOOC), and the implementation of free open access medical education (FOAM) within undergraduate and graduate medical curricula.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Simiao Li-Sauerwine and Andrew King",authors:null}],mostDownloadedChaptersLast30Days:[{id:"74883",title:"Relation between Student Mental Health and Academic Achievement Revisited: A Meta-Analysis",slug:"relation-between-student-mental-health-and-academic-achievement-revisited-a-meta-analysis",totalDownloads:1028,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"In the present research, the relationship between mental health and academic achievement in adolescents was investigated. The research adopted meta-analysis model to investigate the relationship between these two phenomena. In the meta-analysis, 13 independent studies were included, and their data were combined to display effect sizes. According to the result of the research, it was indicated that there was a positive relationship between mental health and academic achievement. Also, it was revealed that there was no significant relationship within sub-group variation in the relationship between mental health and academic achievement in terms of year of publication, publication type, community, and sample size, but not the setting.",book:{id:"10191",slug:"health-and-academic-achievement-new-findings",title:"Health and Academic Achievement",fullTitle:"Health and Academic Achievement - New Findings"},signatures:"Gokhan Bas",authors:[{id:"324308",title:"Associate Prof.",name:"Gokhan",middleName:null,surname:"Bas",slug:"gokhan-bas",fullName:"Gokhan Bas"}]},{id:"66601",title:"Leadership in Graduate Medical Education",slug:"leadership-in-graduate-medical-education",totalDownloads:863,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Graduate medical education (GME) is a very complex endeavor within an even more complex healthcare system. This chapter examines many questions that need to be considered and the role of the key individual with oversight of the GME, the designated institutional official (DIO). Topics examined are the leadership theories, practices and strategies for the DIO, dealing with change when the DIO starts, using authority versus power, effective problem-solving and decision-making, adaptive leadership style, the historical function of the DIO, as well as the many tools available to the DIO including networking. The chapter concludes with several pearls of wisdom to positively help the DIO meet the many challenges of this very important role in GME.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Jay M. Yanoff",authors:null},{id:"63925",title:"Curriculum Development: Foundations and Modern Advances in Graduate Medical Education",slug:"curriculum-development-foundations-and-modern-advances-in-graduate-medical-education",totalDownloads:2330,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Curriculum development has undergone many transitions since the inception of medical education in the United States in the 1800’s. In this chapter, we briefly review the history of curriculum development in medical education. We discuss the landmark models of curriculum development including the concept of a curriculum map and Harden’s SPICES model of educational strategy, detail the six steps of Kern’s foundational framework, and provide an overview of the PRISMS strategy. We address the importance of adult learning theory and the advancing understanding of education for the millennial generation, including implementation of the flipped classroom model of education. Finally, we turn our focus on contemporary applications of curriculum design, including the application of simulation to medical education, the rise of massive open online courses (MOOC), and the implementation of free open access medical education (FOAM) within undergraduate and graduate medical curricula.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Simiao Li-Sauerwine and Andrew King",authors:null},{id:"64979",title:"Teaching Balanced Patient Care Using Principles of Reductionism and Holism: The Example of Chronic Low Back Pain",slug:"teaching-balanced-patient-care-using-principles-of-reductionism-and-holism-the-example-of-chronic-lo",totalDownloads:1017,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"This chapter explores how integrating holistic and reductionistic approaches to care may better optimize value based care. First, we define the terms ‘Holistic,’ ‘Reductionistic’ and ‘Integrative’. Then we explore their scope in the arenas of teaching and patient care, with the advantages, disadvantages and pitfalls of each approach. We review how these styles are embedded in and interact with the cultures of medicine and western societies at large. As an example of a balanced care approach, we focus on the example of chronic low back pain (CLBP), an increasingly common and expensive medical problem. We present practical examples of teaching and practicing these different styles, Holism and Reductionism, illustrating when each may be appropriate to optimize value of patient care. Study questions are included. A list of further readings and resources is included for the interested reader.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Alan Remde, Stephen DeTurk and Thomas Wojda",authors:null},{id:"66801",title:"Physician Burnout",slug:"physician-burnout",totalDownloads:898,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Burnout is pervasive among physicians and is rapidly becoming a pandemic in healthcare. It is characterized by increasing demands without adequate support and hallmarked by depersonalization, emotional exhaustion, and a reduced sense of personal accomplishment. It is essential to address burnout, as it can lead to decreased productivity, increased healthcare costs, medical errors, workforce attrition, depression, and even suicide. Many factors contribute to burnout, and it occurs at all stages of medicine: it can begin during medical school, intensify during the years of graduate medical education (GME) or residency training, and persist as residents become staff physicians. It affects both sexes, but may impact female physicians disproportionately. Impact can also vary among specialties. Recognizing the problem and intervening with unified physician and organization-directed solutions centered on well-being, efficient practice models, and goal prioritization may help to reduce the prevalence and effects of burnout.",book:{id:"8645",slug:"contemporary-topics-in-graduate-medical-education",title:"Contemporary Topics in Graduate Medical Education",fullTitle:"Contemporary Topics in Graduate Medical Education"},signatures:"Bess Connors, Charlotte Horne, Valery Vilchez and Sofya Asfaw",authors:null}],onlineFirstChaptersFilter:{topicId:"1317",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
\r\n
\r\n\t
\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
\r\n\t
\r\n
\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
\r\n
\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
\r\n
\r\n\t
\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. She is also a member of the Analytic Hierarchy Process (AHP) Academy.",institutionString:"Parthenope University of Naples",institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,annualVolume:11976,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,annualVolume:11977,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,annualVolume:11978,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. Since 2015 he heads the research department Sanitation, Water and Solid Waste for Development (Sandec) at the Swiss Federal Institute of Aquatic Research and Technology (Eawag).",institutionString:"Swiss Federal Institute of Aquatic Science and Technology, Switzerland",institution:{name:"Swiss Federal Institute of Aquatic Science and Technology",institutionURL:null,country:{name:"Switzerland"}}},editorTwo:{id:"290571",title:"Dr.",name:"Rui Alexandre",middleName:null,surname:"Castanho",slug:"rui-alexandre-castanho",fullName:"Rui Alexandre Castanho",profilePictureURL:"https://mts.intechopen.com/storage/users/290571/images/system/290571.jpg",biography:"Rui Alexandre Castanho has a master\\'s degree in Planning, Audit, and Control in Urban Green Spaces and an international Ph.D. in Sustainable Planning in Borderlands. Currently, he is a professor at WSB University, Poland, and a visiting professor at the University of Johannesburg, South Africa. Dr. Castanho is a post-doc researcher on the GREAT Project, University of Azores, Ponta Delgada, Portugal. He collaborates with the Environmental Resources Analysis Research Group (ARAM), University of Extremadura (UEx), Spain; VALORIZA - Research Center for the Enhancement of Endogenous Resources, Polytechnic Institute of Portalegre (IPP), Portugal; Centre for Tourism Research, Development and Innovation (CITUR), Madeira, Portugal; and AQUAGEO Research Group, University of Campinas (UNICAMP), Brazil.",institutionString:"University of Johannesburg, South Africa and WSB University, Poland",institution:{name:"University of Johannesburg",institutionURL:null,country:{name:"South Africa"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 7th 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11473",title:"Social Inequality - Structure and Social Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",hash:"cefab077e403fd1695fb2946e7914942",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:19,paginationItems:[{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82701",title:"Pathology of Streptococcal Infections",doi:"10.5772/intechopen.105814",signatures:"Yutaka Tsutsumi",slug:"pathology-of-streptococcal-infections",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yutaka",surname:"Tsutsumi"}],book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82634",title:"Bacterial Sexually Transmitted Disease",doi:"10.5772/intechopen.105747",signatures:"Lebeza Alemu Tenaw",slug:"bacterial-sexually-transmitted-disease",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82552",title:"Perspective Chapter: SARS-CoV-2 Variants - Two Years Post-Onset of the Pandemic",doi:"10.5772/intechopen.105913",signatures:"Adekunle Sanyaolu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Abdul Jan, Priyank Desai, Abu Fahad Abbasi, Jasmine Mangat, Zaheeda Hosein, Kareem Hamdy, Nafees Haider, Nasar Khan, Rochelle Annan, Olanrewaju Badaru, Ricardo Izurieta and Stella Smith",slug:"perspective-chapter-sars-cov-2-variants-two-years-post-onset-of-the-pandemic",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82380",title:"Evolution of Parasitism and Pathogenic Adaptations in Certain Medically Important Fungi",doi:"10.5772/intechopen.105206",signatures:"Gokul Shankar Sabesan, Ranjit Singh AJA, Ranjith Mehenderkar and Basanta Kumar Mohanty",slug:"evolution-of-parasitism-and-pathogenic-adaptations-in-certain-medically-important-fungi",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fungal Infectious Diseases - Annual Volume 2022",coverURL:"https://cdn.intechopen.com/books/images_new/11400.jpg",subseries:{id:"4",title:"Fungal Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:3,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:5,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:10,group:"subseries"}],publishedBooks:{paginationCount:13,paginationItems:[{type:"book",id:"7102",title:"Pneumonia",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7102.jpg",slug:"pneumonia",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Nima Rezaei",hash:"9fd70142814192dcec58a176749f1b60",volumeInSeries:13,fullTitle:"Pneumonia",editors:[{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9615",title:"Chikungunya Virus",subtitle:"A Growing Global Public Health Threat",coverURL:"https://cdn.intechopen.com/books/images_new/9615.jpg",slug:"chikungunya-virus-a-growing-global-public-health-threat",publishedDate:"February 9th 2022",editedByType:"Edited by",bookSignature:"Jean Engohang-Ndong",hash:"c960d94a63867dd12a8ab15176a3ff06",volumeInSeries:12,fullTitle:"Chikungunya Virus - A Growing Global Public Health Threat",editors:[{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",institutionString:"Kent State University",institution:{name:"Kent State University",institutionURL:null,country:{name:"United States of America"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9619",title:"Epstein-Barr Virus",subtitle:"New Trends",coverURL:"https://cdn.intechopen.com/books/images_new/9619.jpg",slug:"epstein-barr-virus-new-trends",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Emmanuel Drouet",hash:"a2128c53becb6064589570cbe8d976f8",volumeInSeries:11,fullTitle:"Epstein-Barr Virus - New Trends",editors:[{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",institutionString:null,institution:{name:"Grenoble Alpes University",institutionURL:null,country:{name:"France"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9525",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",slug:"insights-into-drug-resistance-in-staphylococcus-aureus",publishedDate:"December 8th 2021",editedByType:"Edited by",bookSignature:"Amjad Aqib",hash:"98bb6c1ddb067da67185c272f81c0a27",volumeInSeries:10,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9614",title:"Advances in Candida albicans",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9614.jpg",slug:"advances-in-candida-albicans",publishedDate:"November 17th 2021",editedByType:"Edited by",bookSignature:"Xinhui Wang",hash:"31d6882518ca749b12715266eed0a018",volumeInSeries:9,fullTitle:"Advances in Candida albicans",editors:[{id:"296531",title:"Dr.",name:"Xinhui",middleName:null,surname:"Wang",slug:"xinhui-wang",fullName:"Xinhui Wang",profilePictureURL:"https://mts.intechopen.com/storage/users/296531/images/system/296531.jpg",institutionString:"Qinghai Normal University",institution:{name:"University of Luxembourg",institutionURL:null,country:{name:"Luxembourg"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9613",title:"Dengue Fever in a One Health Perspective",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9613.jpg",slug:"dengue-fever-in-a-one-health-perspective",publishedDate:"October 28th 2020",editedByType:"Edited by",bookSignature:"Márcia Aparecida Sperança",hash:"77ecce8195c11092230b4156df6d83ff",volumeInSeries:7,fullTitle:"Dengue Fever in a One Health Perspective",editors:[{id:"176579",title:"Dr.",name:"Márcia Aparecida",middleName:null,surname:"Sperança",slug:"marcia-aparecida-speranca",fullName:"Márcia Aparecida Sperança",profilePictureURL:"https://mts.intechopen.com/storage/users/176579/images/system/176579.jpg",institutionString:null,institution:{name:"Universidade Federal do ABC",institutionURL:null,country:{name:"Brazil"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",slug:"hepatitis-b-and-c",publishedDate:"April 8th 2020",editedByType:"Edited by",bookSignature:"Luis Rodrigo",hash:"8dd6dab483cf505d83caddaeaf497f2c",volumeInSeries:5,fullTitle:"Hepatitis B and C",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo",profilePictureURL:"https://mts.intechopen.com/storage/users/73208/images/system/73208.jpg",institutionString:"University of Oviedo",institution:{name:"University of Oviedo",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. Saxena",hash:"d92a4085627bab25ddc7942fbf44cf05",volumeInSeries:2,fullTitle:"Current Perspectives in Human Papillomavirus",editors:[{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:754,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"7",type:"subseries",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. His research interests are focused on modern imaging methods used in medicine and pharmacy, including in particular hyperspectral imaging, dynamic thermovision analysis, high-resolution ultrasound, as well as other techniques such as EPR, NMR and hemispheric directional reflectance. Author of over 100 scientific works, patents and industrial designs. Expert of the Polish National Center for Research and Development, Member of the Investment Committee in the Bridge Alfa NCBiR program, expert of the Polish Ministry of Funds and Regional Policy, Polish Medical Research Agency. Editor-in-chief of the journal in the field of aesthetic medicine and dermatology - Aesthetica.",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",slug:"alexandros-tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",slug:"lulu-wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{paginationCount:2,paginationItems:[{id:"82936",title:"Soil Degradation Processes Linked to Long-Term Forest-Type Damage",doi:"10.5772/intechopen.106390",signatures:"Pavel Samec, Aleš Kučera and Gabriela Tomášová",slug:"soil-degradation-processes-linked-to-long-term-forest-type-damage",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}},{id:"82124",title:"Assessment of Diversity, Growth Characteristics and Aboveground Biomass of Tree Species in Selected Urban Green Areas of Osogbo, Osun State",doi:"10.5772/intechopen.104982",signatures:"Omolara Aremu, Olusola O. Adetoro and Olusegun Awotoye",slug:"assessment-of-diversity-growth-characteristics-and-aboveground-biomass-of-tree-species-in-selected-u",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Forest Degradation Under Global Change",coverURL:"https://cdn.intechopen.com/books/images_new/11457.jpg",subseries:{id:"94",title:"Climate Change and Environmental Sustainability"}}}]},publishedBooks:{paginationCount:1,paginationItems:[{type:"book",id:"11392",title:"Leadership in a Changing World",subtitle:"A Multidimensional Perspective",coverURL:"https://cdn.intechopen.com/books/images_new/11392.jpg",slug:"leadership-in-a-changing-world-a-multidimensional-perspective",publishedDate:"May 11th 2022",editedByType:"Edited by",bookSignature:"Muhammad Mohiuddin, Bilal Khalid, Md. Samim Al Azad and Slimane Ed-dafali",hash:"86a6d33cf601587e591064ce92effc02",volumeInSeries:1,fullTitle:"Leadership in a Changing World - A Multidimensional Perspective",editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038UqSfQAK/Profile_Picture_2022-05-13T10:39:03.jpg",institutionString:"Université Laval",institution:{name:"Université Laval",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:18,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"July 5th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:6,numberOfPublishedChapters:90,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},subseries:[{id:"22",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",annualVolume:11418,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13633",title:"Prof.",name:"Abdelhamid",middleName:null,surname:"Mellouk",fullName:"Abdelhamid Mellouk",profilePictureURL:"https://mts.intechopen.com/storage/users/13633/images/1567_n.jpg",institutionString:null,institution:{name:"Paris 12 Val de Marne University",institutionURL:null,country:{name:"France"}}},{id:"109268",title:"Dr.",name:"Ali",middleName:null,surname:"Al-Ataby",fullName:"Ali Al-Ataby",profilePictureURL:"https://mts.intechopen.com/storage/users/109268/images/7410_n.jpg",institutionString:null,institution:{name:"University of Liverpool",institutionURL:null,country:{name:"United Kingdom"}}},{id:"3807",title:"Dr.",name:"Carmelo",middleName:"Jose Albanez",surname:"Bastos-Filho",fullName:"Carmelo Bastos-Filho",profilePictureURL:"https://mts.intechopen.com/storage/users/3807/images/624_n.jpg",institutionString:null,institution:{name:"Universidade de Pernambuco",institutionURL:null,country:{name:"Brazil"}}},{id:"38850",title:"Dr.",name:"Efren",middleName:null,surname:"Gorrostieta Hurtado",fullName:"Efren Gorrostieta Hurtado",profilePictureURL:"https://mts.intechopen.com/storage/users/38850/images/system/38850.jpg",institutionString:null,institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},{id:"239041",title:"Prof.",name:"Yang",middleName:null,surname:"Yi",fullName:"Yang Yi",profilePictureURL:"https://mts.intechopen.com/storage/users/239041/images/system/239041.jpeg",institutionString:"Virginia Tech",institution:{name:"Virginia Tech",institutionURL:null,country:{name:"United States of America"}}}]},{id:"23",title:"Computational Neuroscience",keywords:"Single-Neuron Modeling, Sensory Processing, Motor Control, Memory and Synaptic Pasticity, Attention, Identification, Categorization, Discrimination, Learning, Development, Axonal Patterning and Guidance, Neural Architecture, Behaviours and Dynamics of Networks, Cognition and the Neuroscientific Basis of Consciousness",scope:"Computational neuroscience focuses on biologically realistic abstractions and models validated and solved through computational simulations to understand principles for the development, structure, physiology, and ability of the nervous system. This topic is dedicated to biologically plausible descriptions and computational models - at various abstraction levels - of neurons and neural systems. This includes, but is not limited to: single-neuron modeling, sensory processing, motor control, memory, and synaptic plasticity, attention, identification, categorization, discrimination, learning, development, axonal patterning, guidance, neural architecture, behaviors, and dynamics of networks, cognition and the neuroscientific basis of consciousness. Particularly interesting are models of various types of more compound functions and abilities, various and more general fundamental principles (e.g., regarding architecture, organization, learning, development, etc.) found at various spatial and temporal levels.",annualVolume:11419,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"13818",title:"Dr.",name:"Asim",middleName:null,surname:"Bhatti",fullName:"Asim Bhatti",profilePictureURL:"https://mts.intechopen.com/storage/users/13818/images/system/13818.jpg",institutionString:null,institution:{name:"Deakin University",institutionURL:null,country:{name:"Australia"}}},{id:"151889",title:"Dr.",name:"Joao Luis Garcia",middleName:null,surname:"Rosa",fullName:"Joao Luis Garcia Rosa",profilePictureURL:"https://mts.intechopen.com/storage/users/151889/images/4861_n.jpg",institutionString:null,institution:{name:"University of Sao Paulo",institutionURL:null,country:{name:"Brazil"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",fullName:"Yalcin Isler",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",institutionURL:null,country:{name:"Turkey"}}}]},{id:"24",title:"Computer Vision",keywords:"Image Analysis, Scene Understanding, Biometrics, Deep Learning, Software Implementation, Hardware Implementation, Natural Images, Medical Images, Robotics, VR/AR",scope:"The scope of this topic is to disseminate the recent advances in the rapidly growing field of computer vision from both the theoretical and practical points of view. Novel computational algorithms for image analysis, scene understanding, biometrics, deep learning and their software or hardware implementations for natural and medical images, robotics, VR/AR, applications are some research directions relevant to this topic.",annualVolume:11420,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"1177",title:"Prof.",name:"António",middleName:"J. R.",surname:"José Ribeiro Neves",fullName:"António José Ribeiro Neves",profilePictureURL:"https://mts.intechopen.com/storage/users/1177/images/system/1177.jpg",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"220565",title:"Dr.",name:"Jucheng",middleName:null,surname:"Yang",fullName:"Jucheng Yang",profilePictureURL:"https://mts.intechopen.com/storage/users/220565/images/5988_n.jpg",institutionString:null,institution:{name:"Tianjin University of Technology",institutionURL:null,country:{name:"China"}}},{id:"29299",title:"Prof.",name:"Serestina",middleName:null,surname:"Viriri",fullName:"Serestina Viriri",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOalQAG/Profile_Picture_1620817405517",institutionString:null,institution:{name:"University of KwaZulu-Natal",institutionURL:null,country:{name:"South Africa"}}},{id:"315933",title:"Dr.",name:"Yalın",middleName:null,surname:"Baştanlar",fullName:"Yalın Baştanlar",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002qpr7hQAA/Profile_Picture_1621430127547",institutionString:null,institution:{name:"Izmir Institute of Technology",institutionURL:null,country:{name:"Turkey"}}}]},{id:"25",title:"Evolutionary Computation",keywords:"Genetic Algorithms, Genetic Programming, Evolutionary Programming, Evolution Strategies, Hybrid Algorithms, Bioinspired Metaheuristics, Ant Colony Optimization, Evolutionary Learning, Hyperparameter Optimization",scope:"Evolutionary computing is a paradigm that has grown dramatically in recent years. This group of bio-inspired metaheuristics solves multiple optimization problems by applying the metaphor of natural selection. It so far has solved problems such as resource allocation, routing, schedule planning, and engineering design. Moreover, in the field of machine learning, evolutionary computation has carved out a significant niche both in the generation of learning models and in the automatic design and optimization of hyperparameters in deep learning models. This collection aims to include quality volumes on various topics related to evolutionary algorithms and, alternatively, other metaheuristics of interest inspired by nature. For example, some of the issues of interest could be the following: Advances in evolutionary computation (Genetic algorithms, Genetic programming, Bio-inspired metaheuristics, Hybrid metaheuristics, Parallel ECs); Applications of evolutionary algorithms (Machine learning and Data Mining with EAs, Search-Based Software Engineering, Scheduling, and Planning Applications, Smart Transport Applications, Applications to Games, Image Analysis, Signal Processing and Pattern Recognition, Applications to Sustainability).",annualVolume:11421,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"111683",title:"Prof.",name:"Elmer P.",middleName:"P.",surname:"Dadios",fullName:"Elmer P. Dadios",profilePictureURL:"https://mts.intechopen.com/storage/users/111683/images/system/111683.jpg",institutionString:"De La Salle University",institution:{name:"De La Salle University",institutionURL:null,country:{name:"Philippines"}}},{id:"106873",title:"Prof.",name:"Hongwei",middleName:null,surname:"Ge",fullName:"Hongwei Ge",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Dalian University of Technology",institutionURL:null,country:{name:"China"}}},{id:"171056",title:"Dr.",name:"Sotirios",middleName:null,surname:"Goudos",fullName:"Sotirios Goudos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9IuQAK/Profile_Picture_1622623673666",institutionString:null,institution:{name:"Aristotle University of Thessaloniki",institutionURL:null,country:{name:"Greece"}}},{id:"15895",title:"Assistant Prof.",name:"Takashi",middleName:null,surname:"Kuremoto",fullName:"Takashi Kuremoto",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLrqQAG/Profile_Picture_1625656196038",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}},{id:"125844",title:"Prof.",name:"Wellington",middleName:"Pinheiro Dos",surname:"Santos",fullName:"Wellington Santos",profilePictureURL:"https://mts.intechopen.com/storage/users/125844/images/4878_n.jpg",institutionString:null,institution:{name:"Federal University of Pernambuco",institutionURL:null,country:{name:"Brazil"}}}]},{id:"26",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",annualVolume:11422,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095",title:"Prof.",name:"Kenji",middleName:null,surname:"Suzuki",fullName:"Kenji Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/3095/images/1592_n.jpg",institutionString:null,institution:{name:"University of Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"214067",title:"Dr.",name:"W. David",middleName:null,surname:"Pan",fullName:"W. David Pan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEI9QAO/Profile_Picture_1623656213532",institutionString:null,institution:{name:"University of Alabama in Huntsville",institutionURL:null,country:{name:"United States of America"}}},{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",fullName:"Yves Rybarczyk",profilePictureURL:"https://mts.intechopen.com/storage/users/72920/images/system/72920.jpeg",institutionString:"Dalarna University, Faculty of Data and Information Sciences",institution:{name:"Dalarna University",institutionURL:null,country:{name:"Sweden"}}}]},{id:"27",title:"Multi-Agent Systems",keywords:"Collaborative Intelligence, Learning, Distributed Control System, Swarm Robotics, Decision Science, Software Engineering",scope:"Multi-agent systems are recognised as a state of the art field in Artificial Intelligence studies, which is popular due to the usefulness in facilitation capabilities to handle real-world problem-solving in a distributed fashion. The area covers many techniques that offer solutions to emerging problems in robotics and enterprise-level software systems. Collaborative intelligence is highly and effectively achieved with multi-agent systems. Areas of application include swarms of robots, flocks of UAVs, collaborative software management. Given the level of technological enhancements, the popularity of machine learning in use has opened a new chapter in multi-agent studies alongside the practical challenges and long-lasting collaboration issues in the field. It has increased the urgency and the need for further studies in this field. We welcome chapters presenting research on the many applications of multi-agent studies including, but not limited to, the following key areas: machine learning for multi-agent systems; modeling swarms robots and flocks of UAVs with multi-agent systems; decision science and multi-agent systems; software engineering for and with multi-agent systems; tools and technologies of multi-agent systems.",annualVolume:11423,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/27.jpg",editor:{id:"148497",title:"Dr.",name:"Mehmet",middleName:"Emin",surname:"Aydin",fullName:"Mehmet Aydin",profilePictureURL:"https://mts.intechopen.com/storage/users/148497/images/system/148497.jpg",institutionString:null,institution:{name:"University of the West of England",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"275140",title:"Dr.",name:"Dinh Hoa",middleName:null,surname:"Nguyen",fullName:"Dinh Hoa Nguyen",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRbnKQAS/Profile_Picture_1622204093453",institutionString:null,institution:{name:"Kyushu University",institutionURL:null,country:{name:"Japan"}}},{id:"20259",title:"Dr.",name:"Hongbin",middleName:null,surname:"Ma",fullName:"Hongbin Ma",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRhDJQA0/Profile_Picture_2022-05-02T08:25:21.jpg",institutionString:null,institution:{name:"Beijing Institute of Technology",institutionURL:null,country:{name:"China"}}},{id:"28640",title:"Prof.",name:"Yasushi",middleName:null,surname:"Kambayashi",fullName:"Yasushi Kambayashi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYOQxQAO/Profile_Picture_1625660525470",institutionString:null,institution:{name:"Nippon Institute of Technology",institutionURL:null,country:{name:"Japan"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/188395",hash:"",query:{},params:{id:"188395"},fullPath:"/profiles/188395",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()