Classification and possible diagnosis of anemia according to MCV in clinical use [8].
\r\n\tIn the last decades, particular attention to this field has been paid to the coastal erosion problem all over the world. Indeed, the deployment of artificial reservoirs, modification of the runoff characteristics of internal areas, sand extraction from rivers, and harbor siltation, caused a decrease of sediment input on the coastal environments, and, therefore, a generalized deficit in the sediment budget. Often, dredging activities are required to collect sediment finalized to “soft” techniques to restore beaches or to move the sand trapped in the harbor (clean or contaminated).
\r\n\tMoreover, the coastal protections induced hydrodynamics and morphodynamics modifications inducing sometimes strong variations to the sediment transport regime.
\r\n\tHistorically, all these aspects are related to specific research areas ranging from engineering, geology, geomorphology, biology, etc, but it is difficult to find a comprehensive overview of these topics.
\r\n\r\n\tThis book is intended to collect original works and review concerning numerical and experimental investigation, theoretical works, methodological approaches, and any other technique that allow giving the actual state-of-the-art in the field of sediment transport.
",isbn:"978-1-80355-868-4",printIsbn:"978-1-80355-867-7",pdfIsbn:"978-1-80355-869-1",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"e7b1c1592e32fe87af399022616ad0f8",bookSignature:"Dr. Davide Pasquali",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11136.jpg",keywords:"Longshore Sediment Transport, Sediment Budget, Morphodynamics, Hydrodynamics, Sediment Transport, Sedimentation, Mathematical Modelling, Erosion and Deposition, Dredging, Harbor Siltation, Contaminated Sediment, Water Quality",numberOfDownloads:66,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 4th 2021",dateEndSecondStepPublish:"February 23rd 2022",dateEndThirdStepPublish:"April 24th 2022",dateEndFourthStepPublish:"July 13th 2022",dateEndFifthStepPublish:"September 11th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"4 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Davide Pasquali is currently a Research Fellow in the Department of Civil, Construction-Architectural, and Environmental Engineering (DICEAA) at the University of L’Aquila. 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Anemia is defined as a significant decrease in the count of total erythrocyte [red blood cell (RBC)] mass, although this definition is rarely used in clinical settings. According to the World Health Organization, anemia is a condition in which the number of red blood cells (RBCs, and consequently their oxygen-carrying capacity) is insufficient to meet the body’s physiologic needs [1, 2]. The individual variation such as a person’s age, gender, residential elevation above sea level (altitude), and different stages of pregnancy changes the specific physiologic requirements of the body. Anemia is not a disease, but is instead the sign of an underlying basic pathological process. Nonetheless, the sign may function as a compass in the search for the cause, as well as function as a road marker in the investigation of underlying pathological process [3]. Hence, the diagnosis according to the symptoms obtained by history and physical examination of patients with anemia should be supported by laboratory parameters related to the underlying pathological cause. The first step in the diagnosis of anemia is detection with predictive, accurate tests so that important clues to underlying disease are not missed and patients are not subjected to unnecessary tests for and treatment of nonexistent anemia. Instead, clinicians rely on several other measures to identify the degree and the cause of anemia in a given patient.
The purpose of this chapter is to discuss the clinical approaches with which a practicing physician is able to evaluate a patient with underlying anemia.
Based on determination of the red blood cell mass, anemia can be classified as either relative or absolute. Relative anemia is characterized by a normal total red blood cell mass in an increased plasma volume, resulting in a dilution anemia, a disturbance in plasma volume regulation. However, dilution anemia is of clinical and differential diagnostic importance for the hematologist [4]. Classification of the absolute anemias with decreased red blood cell mass is difficult because the classification has to consider kinetic, morphologic, and pathophysiologic interacting criteria. Anemia of acute hemorrhage is not a diagnostic problem and is usually a genitourinary or gastrointestinal event, not a hematologic consideration.
Initially, anemias should be classified into two groups as diminished production and increased destruction of RBCs. The number of reticulocytes is a remarkable parameter in the materialization of this classification. Then, diagnostic analysis is able to be based upon both morphologic and pathophysiological hallmarks.
Anemias can morphologically be classified into three subgroups as macrocytic, normocytic, and microcytic hypochromic anemias. This classification is based on mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) of complete blood count (CBC) and aids the physician to the diagnosis and monitoring of anemias that can be easily cured, such as deficiency of vitamin B12, folic acid, and iron.
Pathophysiologic classification is best suited for relating disease processes to potential treatment (Figure 1). In addition, anemia resulting from vitamin- or iron-deficiency states occurs in a significant proportion of patients with normal red blood cell indices.
Classification of anemia according to pathophysiologic characteristics (figure has been modified from Ref. [
Each step indicated in Figure 1 can be disrupted and cause anemia. Identifying the affected step is important for therapeutic intervention and specific treatment. The limitation of pathophysiologic classification is that pathogenesis involves several steps in most anemias. Therefore, the provided chapter is a guideline for the practical understanding of the processes underlying the production and destruction of RBCs. Despite all these morphological classification is more useful in terms of convenience and clinical usage. Hence, morphological classification serves to support the diagnosis and indirectly treatment in connection with the laboratory and clinic. The major limitation of such a classification is that it tells nothing about the etiology or reason for the anemia [5].
A comprehensive laboratory evaluation is required for definitive diagnosis and treatment for any anemia, although the anamnesis (history of patient) and physical examination of the patient may indicate the presence of anemia and propose its cause. As appropriate to this aim, the various tests for the diagnosis of anemia are done with routine hematological tests such as CBC and reticulocyte counts as well as studies of iron status that serve as a leaping point to the diagnosis (Figure 2). When the diagnosis of specific anemic conditions is confirmed, a large number of other specific tests are used [6]. Laboratory tests used in the diagnosis of anemia are roughly summarized in Figure 2. The laboratory investigation of anemias involves the quantitative and semiquantitative measurements of RBCs and supplementary testing of blood and body fluids. The laboratory results obtained from these parameters are important arguments in the diagnosis, treatment, and monitoring of the anemias.
Laboratory tests used in anemia diagnosis (figure has been modified from Ref. [
Prior to the development of modern hematology blood analyzers, blood counts included hemoglobin (Hb) concentration, white blood cell (WBC) count, and manual platelet count. The other parameters like mean corpuscular volume (MCV) had to be mathematically calculated by using the measured parameters such as Hb, RBC count, and hematocrit (Hct). Modern analyzers provide CBC indices by using various physical and chemical methods such as electronic impedance, laser light scattering, light absorption, and staining properties [7].
How will CBC parameters such as Hb concentration, Hct, RBC count, MCV, MCHC, WBC count, platelet count, and other parameters related to formed elements of blood measured by modern blood analyzers help the diagnosis or management of the patient? CBC identifies several different parameters and can provide a great deal of information. Hematologic and biochemical variations of red blood cells determine whether the patient is anemic or not. If anemia is present, MCV is likely to provide clues about the cause of anemia. While an infection can lead to increased WBC, lymphocytosis can be seen in viral infections (but not always so). Abnormal size or number of platelets may be either due to the direct effect of any underlying blood disease or may simply be the reflection of the presence of some other underlying pathologies. Because of all these, CBC parameters obtained as a result of clinical evaluation should be reassessed more carefully and curiously [7]. Therefore, the fundamental parameters of CBC such as Hb concentration, RBC, Hct, MCV, mean corpuscular hemoglobin (MCH), MCHC, and red blood cell distribution width (RDW) which plays an important role in the diagnosis, treatment, and monitoring of the anemic patient will be explained below.
Determination of Hb is a part of CBC. Hemoglobin is intensely colored, and this property has been used in methods for estimating its concentration in the blood. Erythrocytes contain a mixture of hemoglobin, oxyhemoglobin, carboxyhemoglobin, methemoglobin, and minor amounts of other forms of hemoglobin [4].
Monitoring the response to treatment of anemia and to evaluate polycythemia, Hb concentration is used to screen for diseases associated with anemia and to determine the severity of anemia [6]. Finding an
Variations in Hb levels occur after hemorrhages, transfusions, and burns (Hb and Hct are both high during and immediately after hemorrhage). Hb and Hct supply valuable information in an emergency situation [8].
Excessive fluid intake, pregnancy, and drugs, etc., which cause increase in plasma volume and decrease the Hb values, are interfering factors. Drugs such as methyldopa and extreme physical exercise can give rise to increased Hb levels. In addition, people living in high altitudes have increased Hb concentration, Hct, and RBC count [8].
The quantification of the percentage of microcytic and hypochromic RBCs has proved its clinical usefulness in the differential diagnosis of microcytic anemia [9]. RBC count has been recognized as the most efficient single classical measurement in the differential diagnosis of microcytic anemia [10]. Iron-deficient erythropoiesis is characterized by the production of RBC with a
In β-thalassemia cases, increased RBC count is a characteristic as a result of chronic increase in erythropoiesis. Therefore, MCV and MCH are lower in beta thalassemia than in iron deficiency anemia [11].
The word hematocrit, also called packed cell volume (PCV), means “to separate blood,” which underscores the mechanism of the test, because the plasma and blood cells are separated by centrifugation [6].
The size and hemoglobin content of erythrocytes (red blood cell indices), based on population averages, have traditionally been used to assist in the differential diagnosis of anemia [13]. Some red blood cell parameters (for instance, RBC count, Hb concentration, MCV, RDW) are directly measured, while the others (e.g., Hct, MCV, MCHC) are derived from these primary measurements [14]. These measurements are provided by any of the common automated instruments. Instruments vary somewhat in their technologies. The most commonly used method is either a combination of a highly focused light source, an electric field, and a laser-based flow cytometry or a radiofrequency wave to discriminate between cells. Automated instruments are not only fast but extremely accurate. The coefficient of variation (measurement error) of an automated counter is usually less than 2%, and each of the major measurements, including the hemoglobin level, red blood cell count, and mean corpuscular volume, can be standardized independently with commercial red blood cell and hemoglobin standards [4, 6, 12].
MCV has been used to guide the diagnosis of anemia in patients, for example, testing patients with microcytic anemia for iron deficiency or thalassemia and those with macrocytic anemia for deficiency of folate or vitamin B12 [4, 15].
The reference value of MCV ± 2 SD is 90 ± 9 fL and generally coincides with the peak of the Gaussian distribution of RBC size. Although MCV is both accurate and highly reproducible, errors may be introduced by RBC agglutination, distortions in cell shape, the presence of very high numbers of WBCs, and sudden osmotic swelling [8]. MCV results are the basis of the classification system used to evaluate an anemia (Table 1, Figure 3).
• Disorders of iron metabolism | Iron deficiency anemia, anemia of chronic disease, congenital hypochromic-microcytic anemia with iron overload |
• Disorders of porphyrin and heme synthesis | Acquired sideroblastic anemias, idiopathic refractory sideroblastic anemia |
• Disorders of globin synthesis | Thalassemias, hemoglobinopathies, characterized by unstable hemoglobins |
• Anemia with appropriate bone marrow response | Acute posthemorrhagic anemia, hemolytic anemia |
• Anemia with impaired marrow response | Aplastic anemia, pure red blood cell aplasia, myelofibrosis |
• Cobalamin (B12) deficiency | Lack of animal products, intrinsic factor deficiency, pernicious anemia, hyperthyroidism, pregnancy, enzyme deficiencies |
• Folate deficiency | Lack of vegetables, celiac disease, hypothyroidism, folic acid antagonists, hemodialysis |
• Unresponsive to cobalamin or folate | Metabolic inhibitors (i.e., 6-mercaptopurine), inborn errors (Lesch-Nyhan syndrome) |
Classification and possible diagnosis of anemia according to MCV in clinical use [8].
Flowchart to follow in the diagnosis of anemia according to MCV [
Increased reticulocytes and marked leukocytosis can also increase MCV [8]. The mixed population of microcytes and macrocytes results in normal MCV values and is an
MCH, the amount of hemoglobin per red blood cell, increases or decreases in parallel with MCV and generally provides similar diagnostic information. Because this parameter is affected by both hypochromia and microcytosis, it is least sensitive as MCV in detecting iron deficiency states [16].
The reference value of MCH is 32 ± 2 pg. This is an excellent measure of the amount of hemoglobin in individual red blood cell. Patients with iron deficiency or thalassemia who are unable to synthesize normal amounts of hemoglobin show significant reductions in the MCH [8, 17].
An
Hyperlipidemia is one of the
MCHC is not used frequently for diagnostic purpose, but is primarily useful for quality control purposes, such as detecting sample turbidity. Because MCHCs are average quantities in the blood with mixed-cell populations, it is difficult for these red blood cell indices to detect abnormalities in the blood [4].
The reference value of MCHC is 33 ± 3 g/dL. The principal purpose of MCHC is to detect patients with hereditary spherocytosis who has very small, dense spherocytes in the circulation. These spherocytes represent cells that have lost considerable intracellular fluid because of a membrane defect. In situations such as sideroblastic anemia, recently transfused patients, patients with severe pernicious anemia with red blood cell fragmentation, and in conditions where both folate and iron deficiency are present, both large and small red blood cells are observed, which compromise the value of MCV. When present in significant numbers, they will cause MCHC to increase to levels in excess of 36 g/dL [4, 6, 15].
Because of falsely elevating MCHC, lipemia, cold agglutinins or rouleaux, and high heparin concentrations may be among the
RDW is an estimate of the variance in the volume within the population of red blood cells [4]. RDW, provided by automated counters, is an index of the distribution of RBC volumes. RDW is derived from pulse height analysis and can be expressed as an SD (fL) or as a coefficient of variation (%) of the red cell volume. Automated counters use two methods to calculate RDW [6]. The first is referred to as
Red blood cell distribution width. Automated counters provide measurements of the width of the red blood cell distribution curve. RDW-CV is calculated from the width of the histogram at 1 SD from the mean divided by MCV [
Both measurements of RDW are essentially mathematical statement of anisocytosis.
The RDW can be used to distinguish thalassemia (normal RDW) from iron deficiency anemia (high RDW). Also, it can be used to distinguish chronic disease anemia (normal RDW) from early iron deficiency anemia (elevated RDW). RDW increases in iron deficiency anemia, vitamin B12 or folate deficiency (pernicious anemia), abnormal Hb (S, S-C, or H), S-β thalassemia, immune hemolytic anemia, marked reticulocytosis, and posthemorrhagic anemia.
The RDW may be an alternate marker for systemic inflammation and/or oxidative stress; however, the predictive value of RDW is independent of other inflammatory markers. This suggests that this biomarker also follows other nonempirical processes [8, 17]. The determination of the physiological and biological mechanisms that associate RDW to adverse clinical results is important in using these prognostic biomarkers to therapeutic decisions [18].
Peripheral blood smears can provide important additional information about RBC morphology in anemia and are easily prepared manually using glass slides. The hematology laboratory usually examines a peripheral blood smear if the patient’s indices are abnormal (unless there has been no major change from previous CBCs). If an underlying blood disorder is suspected, a film should be requested. Automated instruments ensure accurate RBC counts and indices and WBC counts and differentials in both healthy and diseased individuals [8, 19].
The peripheral blood smear complements the automated countermeasurements of MCV and MCH. Visible changes in cell diameter, shape, and hemoglobin content can be used to distinguish both microcytic and macrocytic cells from normocytic/normochromic RBCs (Table 2) [6].
The patterns of some abnormal RBCs | Comment |
---|---|
Macrocyte | Larger than normal (>8.5 μm diameter) |
Microcyte | Smaller than normal (<7 μm diameter) |
Hypochromic | Less hemoglobin in the cell. Enlarged area of central pallor |
Spherocyte | Loss of central pallor, stains more densely, often microcytic. Hereditary spherocytosis and certain acquired hemolytic anemias |
Target cell | Hypochromic with central “target” of hemoglobin. Liver disease, thalassemia, Hb D, and postsplenectomy |
Leptocyte | Hypochromic cell with a normal diameter and decreased MCV. Thalassemia |
Elliptocyte | Oval to cigar shaped. Hereditary elliptocytosis, certain anemias (particularly vitamin B12 and folate deficiency) |
Stomatocyte | Slit-like area of central pallor in erythrocyte. Liver disease, acute alcoholism, malignancies, hereditary stomatocytosis, and artifact |
Acanthocyte | Five to ten spicules of various lengths and at irregular intervals on surface of RBCs |
Echinocyte | Evenly distributed spicules on surface of RBCs, usually 10–30. Uremia, peptic ulcer, gastric carcinoma, pyruvate kinase deficiency, and preparative artifact |
Sickle cell | Elongated cell with pointed ends. Hb S and certain types of Hb C |
Various forms and interpretations of RBCs observed in the peripheral blood smear examination [31].
In clinical cases, the variation such as staining, color, shape, and inclusion bodies in the blood smear of RBCs is not only an indication of RBC abnormalities but also a diagnosis of diseases.
Reticulocyte count is an essential component of CBC and has a substantial role in initially classifying any anemia. Reticulocytes are newly formed red blood cells with residual strands of nuclear material called “reticulin” that remain following extrusion of the nucleus from bone marrow normoblasts [20]. The reticulocyte is a young red blood cell containing residual ribosomal RNA that can be stained with a supravital dye such as acridine orange or new methylene blue [4]. The reticulocyte count can be used in differentiation of the patients with a functionally normal marrow response to anemia/hypoxia and those with a failed marrow response. Whenever the reticulocyte production index (RPI) increases to levels greater than three times normal in response to an anemia (hematocrit <30%), it can be assumed that the patient has normal renal function with an appropriate erythropoietin response and a normal erythroid marrow with an adequate supply of key nutrients (iron, folic acid, and vitamin B12) [6, 15].
Reticulocytosis, increased RBC production, occurs when the bone marrow is replaced, is lost, or has prematurely destroyed cells. Identifying reticulocytosis is important for the recognition of other clinic conditions such as hidden chronic hemorrhage or unrecognized hemolysis (e.g., thalassemia, sickle cell anemia). Reticulocyte levels increase in hemolytic anemia, immune hemolytic anemia, primary RBC membrane problems, hemoglobinopathy, RBC enzyme deficits, and malaria.
If there is not enough erythrocyte production in the bone marrow, the reticulocyte count decreases in untreated iron deficiency anemia and aplastic anemia, untreated pernicious anemia, anemia of chronic disease, radiation therapy, endocrine problems, tumor in the marrow (bone marrow failure), myelodysplastic syndromes, and alcoholism.
Some other laboratory tests are useful to define the physiologic defects responsible for anemia. Indirect serum bilirubin and lactic dehydrogenase (LDH) levels increase in patients with increased hemolysis and in ineffective erythropoiesis. Indirect bilirubin levels correlate with RBC turnover rate. Serum LDH is exceedingly responsive to increased rates of RBC destruction (because of the excess levels of LDH 1 in RBCs) [8, 21].
Reticulocyte hemoglobin content (CHr or Ret-He) measurement demonstrates Hb synthesis in marrow precursors. Ret-He also reflects the early stages of iron deficiency. Ret-He is defined as an auxiliary parameter in the differential diagnosis of anemias.
Current high-end automated cell counters measure unique properties of mature red blood cells and reticulocytes on a cell-by-cell basis, not just as population averages. This results a plethora of new indices that are in many cases specific to an instrument manufacturer, presenting diagnostic opportunities but also a confusing nomenclature and a potential lack of comparability. Some examples of parameters that have been studied include hypochromic erythrocytes (
Ret-He demonstrates the real-time information on the synthesis of young RBCs in the bone marrow. Other available parameters are the percentage of RBCs with Hb content equivalent ≤17 pg (HypoHe%) and the percentage of RBCs with a volume of <60 fL (MicroR%), which reflects the subpopulation of mature RBCs exhibiting evidence of insufficient iron content [6, 8].
Estimates of reticulocyte-specific hemoglobin content (which are comparable) by light-scatter measurements of reticulocytes are closely related to adequacy of iron availability to erythroid precursors during the preceding 24–48 hours and have been described as diagnostically useful in detecting functional iron deficiency [8, 22].
The CHr may be a better predictor of depleted marrow iron stores than traditional serum iron parameters in nonmacrocytic patients and is a more sensitive predictor of iron deficiency than hemoglobin for screening infants and adolescents for iron deficiency [25, 26].
Bone marrow examination has a special place in the cause of anemia since it is the organ of blood production [20]. The marrow examination is of greatest value in patients who fail to show an appropriate increase in the reticulocyte production index in response to anemia. A sample of the marrow can easily be obtained by needle aspirate or biopsy to evaluate overall cellularity, the ratio of erythroid to granulocytic precursors (E/G ratio), and cellular morphology. In these patients defects in erythroid precursor proliferation or maturation play a major role. Examination of any marrow aspirate should include a careful assessment for evidence of a red blood cell maturation abnormality, especially changes in cell size, nuclear morphology, and hemoglobin production. A number of anemias are characterized by distinct abnormalities in the maturation sequence and the morphology at each stage of maturation [6]. The assessment of the bone marrow is the gold standard in iron deficiency. The presence of the mineral in reticuloendothelial cells is the key to the diagnosis [20].
Iron supply tests (serum iron level, transferrin iron-binding capacity, and serum ferritin level) play an important role in the initial differential diagnosis of an anemia. They are essential components to the marrow iron stain whenever a marrow aspirate is performed [8, 22, 25].
Serum iron levels. This is serum iron (SI) measurement which reflects an amount of iron bound to transferrin. The reference range of SI level is 50–150 μg/dL for an individual. The proliferative capacity of the erythroid marrow and its ability to synthesize hemoglobin are assessed by serum iron level [6].
Total iron-binding capacity (TIBC). The amount of iron which is bound to transferrin is called TIBC. Actually, it is equivalent to measuring the level of transferrin. The reference value of TIBC is 300–360 μg/dL. TIBC increases in excess of 360 μg/dL in patients with severe iron deficiency.
Serum ferritin level. Ferritin is a spherical protein and is used clinically to evaluate total body storage iron (body iron stores). A normal adult male has a serum ferritin level of between 50 and 150 μg/L, reflecting iron stores of 600–1000 mg. Serum ferritin levels decrease when the iron stores are depleted. Levels below 10–15 μg/L indicate iron deficiency due to exhaustion of iron store [6].
For the diagnosis of specific hematopoietic disorders, there are some other laboratory tests. Table 3 demonstrates some of the special assays for such disorders [1, 4].
Hypoproliferative anemias | Maturation disorders | Hemolytic anemias |
---|---|---|
*Cytometric assay of CD59/CD55 levels (paroxymal nocturnal hemoglobinuria) *Chromosomal analysis (leukemias) *Marrow aspirate/biopsy special stains • Trichrom stain, silver stain for reticulin (myelofibrosis) | *Serum vitamin B12 level (vitamin B12 deficiency) *Serum RBC folate level (folic acid deficiency) *Hb electrophoresis (abnormal hemoglobins) *Hb A2 level-HPLC (β-thal) *Hb F level-HPLC (β-thal) RBC protoporphyrin level (iron deficiency) Brillant aresyl blue stain | *Hb electrophoresis and HPLC (hemoglobinopathies) *Coombs test (autoimmune hemolytic anemia) *Cold aglutinin titer (autoimmune hemolytic anemia) *Haptoglobin level (hemolysis) *G6PD screen (G6PD deficiency) |
Specific hematopoietic disorders and the associated laboratory tests [6].
The flowchart that follows is intended as a first approach for the diagnosis of anemia and is a supplement to this chapter to demonstrate how the steps might be placed in a logical order (Figure 3).
A CBC and differential and reticulocyte counts together with stained peripheral blood smear examination should be the starting point of investigations. These confirm the clinical suspicion of anemia and direct further investigation [5].
The points to be followed in Figure 5 (A–F) may help to begin anemia investigation:
Flowchart as a first approach to diagnose anemia. In anemic patients, approaches should follow according to MCV and RDW because of their comprehensibility and simplicity [
The RBC performs some functions such as transportation of O2 and CO2. An increase in RBC is referred as polycythemia. Patient may have α- or β-thalassemia. Confirm abnormal hemoglobins with electrophoresis, Hb A2 value in β-thalassemia will be >3.5%, check if there are target cells, etc. A decrease in RBC accounts for less hemoglobin. If RBC count is low, patient iron status should be checked (iron, TIBC, Sat%, ferritin, etc.).
Red blood cell fragmentation can be investigated. Fragmented red blood cells (FRCs) and hemolysis occur when RBCs get stressed through partial vascular occlusions or over abnormal vascular surfaces. “Split” RBCs, or schistocytes, are considered on peripheral blood smears under these conditions; significant quantities of lactate dehydrogenase are released into the blood from injured RBCs [4].
The ethnicity of the patient is important for this situation.
Check the patient for sickle cell disease (SCD). If the patient is normal for SCD, investigate iron deficiency anemia.
Reticulocyte count and indices: Reticulocytes are stained by supravital staining. Typical normal range is 0.5–1.5%. The count depends on total RBC count [12]. For both the pathophysiological classification of anemia and to monitor marrow response after therapeutic interventions, reticulocyte count is clinically important [11, 19].
Reticulocyte count was used in the clinical and laboratory practice for a long time due to three main factors: technical limitations in the detection of cell, the imprecision of manual microscopic method, and high coefficient of variations in counts [28, 29]. The index is the corrected value in relation to total red blood cell mass and Hb%. Increased count indicates increased red blood cell turnover. Reticulocyte count can be used as a measure of red blood cell production by correcting red blood cell count for both changes in hematocrit. The result of correction reflects the effect of erythropoietin on reticulocyte release from the marrow [6].
Obtain single correction reticulocyte count (reticulocyte index) (S):
Double-corrected reticulocyte count or reticulocyte production index (RPI) is calculated by dividing the single correction reticulocyte count by the maturation index.
In situations where the reticulocyte count is elevated, other possibilities should be investigated, for example, serum haptoglobin and hemopexin, which are degraded hemoglobin-bound complexes, are impaired and can’t be monitored in acute intravascular hemolysis. Unconjugated bilirubin in serum and urobilinogen in urine should be also measured. Unconjugated hyperbilirubinemia in the absence of urobilirubinogen in urine is a marker of hemolysis [12].
If reticulocyte production index (
If
If
Screen for uncorrected reticulocyte count if the patient has any morphological abnormalities screen for uncorrected reticulocyte count.
Often, the etiology of a patient’s anemia can be determined if the shape or size of RBCs is altered or if they include inclusion bodies (Table 2).
The levels of ferritin and RBC folate/vitamin B12 should be examined to confirm/exclude the possible early diagnosis of iron deficiency anemia, sideroblastic or megaloblastic anemia, mixed deficiency, and myeloproliferative disorder. Serum transferrin receptor, homocysteine, and methylmalonic acid levels can be also considered.
In severe hemolytic anemia, spherocytosis and RBC fragmentation may be seen in the stained film. Although drug-induced hemolysis may indicate “bite cells” in the blood of patients with G6PD deficiency, this may not always be associated with G6PD deficiency because such cells are generally not found in patients with acute hemolytic conditions of chronic G6PD variants or patients with chronic hemolytic G6PD deficiency [4]. Repeat the history and physical examination for splenomegaly.
The pattern of folate or vitamin B12 of the patient should be checked. The homocysteine, methylmalonic acid, LDH, and indirect bilirubin values can be investigated. It is necessary to evaluate the intrinsic factor and parietal cell antibody to confirm or exclude pernicious anemia.
The proper use and interpretation of laboratory tests are important in the diagnosis and treatment of anemia. Whether the patient is anemic can be determined by using Hb, Hct, or RBC count and the reference intervals for age and sex or the patient’s previous values [31]. Routine examination of the blood includes CBC and examination of a stained peripheral blood smear. The values could be normal in mild anemia with RBC count in normal range [32].
There is no single optimal marker or test combination in the differential diagnosis of anemias [33]. The knowledge and experience of the physician who demands appropriate hematological and biochemical tests related to preliminary diagnosis have the important role in the diagnosis of anemias. It is recommended to use algorithms as a tool in determination of anemias in order to reduce the laboratory tests and accurately diagnose the underlying cause(s) in patients.
For the past decade, remarkable progress has been made in the procedures and algorithms in the differential diagnosis of anemias. CBC is the main procedure for investigating anemia. The percentage of microcytic RBCs is considered in the first step. In the second step, MCV, RDW, and RBC count should be examined. It is advocated that innovative algorithms, including parameters reflecting hemoglobinization of RBCs and reticulocytes, are integrated to improve the differentiation between anemias. Subsequently, new algorithms, including conventional as well as innovative hematological parameters, were assessed for subgroups with microcytic erythropoiesis. Nowadays automated reticulocyte counts provide new parameters to evaluate marrow activity [29]. It is therefore important to establish accurate and reliable criteria for both identifying the specific causes of anemia and evaluating the impact of intervention strategies. These should be followed by laboratory tests that are mandatory and simple to perform.
CBC is the most sensitive measure in the routine use to obtain the information about the presence and severity of anemia.
For the evaluation of anemia, there are some essential basic laboratory tests such as CBC, reticulocyte count, blood smear morphology changes, iron balance studies, and bone marrow morphology reports.
Severity of the hematocrit/hemoglobin changes in MCV, RDW, and blood smear morphology are the first parameters to evaluate anemia. These help to define the anemia as normocytic, microcytic, or macrocytic.
Reticulocyte index defines the adequacy of the erythropoietin and red blood cell production response.
Bone marrow examination can also provide information about proliferative response and whether there is any defect in precursor maturation.
Iron studies should also be included in the investigation of anemia.
In conclusion, identification of the cause of anemia by the clinician with the support of laboratory data is an important step to diagnose, treat, and monitor the underlying pathological process.
After the collapse of the Soviet Union in 1991, the whole food chains in Armenia and other Eastern European countries experienced an economic breakdown due to the beginning of the transition process. Problems occurred at the beginning of the transformation process. After land privatisation, and the liberalisation of prices and trades, the prevailing structures did not fit to the open market [1].
Disruption and instability in the supply chain from farmers to retailers had a negative impact on qualities and quantities. At the same time, changing consumer demands forced retailers and processors to adjust and improve the structure of the food chains to meet consumer demands and to overcome the supply problems. The agricultural policy could not provide frameworks and institutions fast enough to restructure the food commodity chains to guarantee stable and higher qualities as well as quantities. As a consequence, retailers and processors were engaged mainly in the approach of private-driven vertical coordination with partners along the supply chain to overcome the problems of supply disruption and minor quality [2, 3]. These structural changes and their consequences are still present today.
To adapt to the new environment, the Yerevan Brandy Company (YBC), the producer of Ararat brandies, was acquired by the international Pernod Ricard Group with French origin in 1998, shortly after the collapse of the Soviet Union.
Investments of foreign companies can cause structural changes in the agri-food sector. The requirements of the newly established procurement systems demand that suppliers can guarantee both disruption-free product flows and delivery of products of a certain quality, thus forcing domestic producers to keep up with quantity and quality demands to prevent the import of products [4].
Literature on the influence of foreign direct investment (FDI) on transition economies mentions several positive effects of FDI such as follows: (1) it facilitates economic growth [5, 6], (2) it reduces poverty [7, 8], and (3) it can induce technology transfer, technical innovation as well as enterprise restructuring [7]. Dyker points out that those investing companies have to impose their corporate organisational structures on subsidiaries or partners [9]. Those organisational structures are based on the disposition of hierarchies, lines of responsibility, the use of intra-firm e-mail systems, etc. Hanf et al. show the influence that foreign investors have taken in the development of the Armenian wine and brandy business. They use different Armenian companies, among others, the YBC [10].
This is why we take the YBC as a case study to show exemplarily how an international company manages to integrate local smallholders (grape growers) into their national and international value chains by successfully installing a procurement system by using different measures of vertical coordination.
The case of the YBC in the Armenian brandy industry can be seen as a benchmark example for other countries and their agricultural sectors where the structure of smallholders is still prevailing, too. Based on the case study, we derive implications for the participants.
The chapter is structured as follows. To show the theoretical background on integration of smallholders into value chains, the next chapter gives an overview about vertical coordination, and vertical coordination mechanisms, i.e., contracting in productive partnerships.1 In the third chapter, background information on the Armenian wine industry is provided. The fourth chapter presents the case study results from the Yerevan Brandy Company. Finally, concluding remarks are offered.
In everyday business, companies face decisions about the synchronisation of successive stages in the marketing channel from producers to consumers. Traditionally either spot market transactions or integrated processes in companies have been used. The spot market and vertical integration can be considered as classical modes, which continue to be applied in nowadays businesses.
The spot market represents the classic
Vertical integration is considered to be the
The classic
Vertical coordination can be described as the synchronisation of successive stages in the marketing channel from producers to consumers, leaving out spot market transactions, where the commodity exchange is only based on pricing. Productive partnerships, a kind of vertical integration, are characterised by collaborations of independent firms, in which the partners share interests as well as knowledge and resources to improve the outcomes of the supply chain activity. Productive partnerships can be based on specification contracts (production and marketing contracts2), relational-based alliances and equity-based alliances [12]. It can take different organisational forms possible: from loose or tacit agreements to stable, long-term and trust-based cooperation contracts [14, 17].
One can assume that the higher the priority to secure quality and/or quantity of raw materials, the stronger is the shift from spot market transactions towards advanced vertical coordination mechanisms [18]. This is closely related to the intensity of control, which increases along the continuum (Figure 1). With spot markets, the intensity of control is low, as exchange partners decide on whether to realise the transaction or not. With specification contracts, the control increases from that related to spot markets. As in relation-based alliances, involved firms share risks and benefits; coordination control arises from mutual interests and decision-making. In equity-based alliances, the intensity of control is even higher, because partners are key stakeholders and control and decision-making are decentralised among the ownership parties. Examples for equity-based alliances are cooperatives and joint ventures [12, 15].
Framework vertical coordination (based upon [
The key for all types of vertical coordination is contracting. Vertical coordination aims to overcome the disruptions in supply and inferior-quality products. However, the key actors (retailers and processors) find themselves constrained not by their capital capacity but by that of other participants along the chains on which they depend for critical inputs. This is because traditional lending institutions such as banks do not give credit to enhance the inter-firm product flow. Contract farming can be defined as an agreement between legally independent firms for the production of a commodity or product for a future market [16]. Götz et al. state: “An essential element of contract farming is the provision of some degree of assistance to the farmers, with the aim of increasing supply quantity or quality, or reducing seasonality” ([19], p. 364). Overall, farm assistance can include input supply programmes, investment assistance, trade credits, bank loan guarantees, extension and management advisory services, etc [4]. Thus, farm assistance programmes must be accompanied by appropriate governance mechanisms.
Production contracts (resource-providing contracts) are predominantly used to address quality concerns [20]. Developed markets have various consumer segments with differentiated demands. In production contracts, the contractor provides, on the one hand, a market for the goods and, on the other hand, engages in many of the producer’s decisions and retains ownership of essential production inputs to secure higher-quality products to attend to the differentiated demands of the consumer segments [21]. However, when the higher-quality products become standardised (e.g. IFS or GlobalGAP certified) and there are no supply difficulties and/or the overall product quality is not complex, mainly marketing contracts will be used.
Marketing contracts address only the issue of supply disruptions by private contractual initiatives [22, 23]. The contractor usually provides a market for the goods but—on the contrary to production contracts—engages in few or none of the producer’s decisions. In marketing contracts, the contractor and producer may negotiate the delivery schedule, pricing method and product characteristics.
For both types of contracts, Swinnen states that “these private contract initiatives can be quite substantial” ([2], p. 1). Empirical evidence indicates that they include farm management assistance, extension services, quality controls, farm input assistance programmes, trade credits and even bank loan guarantees. The programmes generate essential improvements in the credit situation of the farms, as they contribute directly to improved access to finance (e.g. through trade credit) and indirectly as they improve contracting farms’ access to loans from banks or external financial institutions (through loan guarantees, enhanced farm profitability and improved future cash flows). Summing up, there are different factors influencing participants towards contract arrangements.
The main reason why processors enter into contracts includes the control over input supply. Further, processors use contracts to achieve uniformity and predictability to suit consumers, but they also benefit from lower costs in processing, packing and grading [24, 25, 26, 27].
The main motivating factors for farmers to enter into contracts are the following, as reported by the USDA (1996): (I) income stability (to reduce risk compared to other ways of selling on traditional marketing channels); (II) improved efficiency (management decisions are transferred to the farmers); (III) market security (entering the contract provides a certain security in that the product will be sold if it meets with the requirements); and (IV) access to capital (contractor often provides inputs for farmers, which reduces the usage of credits) [28].
However, two reasons for the breaching of contracts have been detected. First, a lack of trust in business relations between producers and their buyers, as in transition countries, many buyers experienced that businesses were not able to pay. According to Ring and Van de Ven, trust is not built based on contracts; it rather emerges over time due to the commitment of assets or satisfactory performance [29].
Second, they may not be able to fulfil a contract because they cannot access basic production factors [23]. Contract enforcement is still an important problem. In the World Bank study, the enforcement problem was regarded as one of the most important barriers for successful vertical coordination [4]. However, in some cases, public enforcement institutions are not fully functioning. Furthermore, since transition countries are often described as having limited social capital, there is also an absence of societal enforcement mechanisms (e.g. peer or community pressure, a sense of mutual obligation and an overall sense of distrust). Thus, to improve the farmer’s access to basic production factors (capital and specific inputs) and know-how/information (knowledge and experience), means have to be worked out and put down in writing, i.e., contracts have to be signed [4].
The change to modern procurement systems is one reason for initiating vertical coordination and, therefore, chain-based financing. The requirements set by these systems favour large-scale farm production for two purposes: (1) significantly fewer large suppliers are needed, and hence the complexity of the system is lowered, which decreases transaction costs, and (2) it is more costly to assist small farms than larger farms [4]. As a result, many retailers and processors would like to see growth in farm size.
However, retailers and processors are (still) forced to include smallholders. Smallholders are essential for ensuring the required quantities in some countries. Particularly in labour-intensive sectors, small-scale farming has significant cost advantages. If the (farm) suppliers get too large, they begin to recapture some power. Since larger farms have the feeling that they can survive just by themselves, it may be more likely that smaller farmers join horizontal collaborations and ultimately create much larger units. The degree of market development is essential for the degree of vertical coordination. The less a market and its institutional environment are developed, the less likely it is that a complex system of vertical coordination will emerge (where marketing contracts are dominant). The more developed a market (i.e. the greater the demand for higher-quality products), the higher the degree of vertical coordination will be, and production contracts are favoured. These contracts vary in control allocation and risk transformation across stages.
Figure 2 sums up the elements of contracting in productive partnerships.
Contracting in productive partnerships.
During the communist era, the satellite countries were divided to focus on the production of particular products. Therefore, Armenian table wine production was shifted mainly to brandy production, which led to a significant change in the Armenian wine culture. Other countries, such as Georgia and Moldova, were focusing on wine production, which preserved the wine culture within these countries [30].
The production area has gone through a tremendous decline after a very peak in 1985 with 35,000 ha (~88.4 million litres). During the Soviet times, Armenia processed more than 200,000 tons of grapes mostly for brandy, a little bit of wine and sparkling wine. The major part of the production was consumed in Russia and the empire of the Soviet Union. Especially the anti-alcohol campaign in 1985 initiated by Michail Gorbatschow had an enormous influence on the area until the collapse of the Soviet Union in 1991 [31]. His goal was to improve the Soviet morale, to reduce the expenses and deaths due to high alcohol consumption. Many old vineyards were cut off or removed to reduce the production of alcoholic beverages [32]. Figure 3 gives an overview of the wine production from 1971 to 2017.
Wine production (incl. base wine for brandy) in million litres in Armenia from 1971 to 2017 annually (based upon [
In the post-Soviet period, the grape-growing industry declined heavily in Armenia and other Soviet countries, and so did the wine sector due to changes in land privatisation. Other influencing factors were the absence of replantation of vineyards and the shift of some farmers to other more profitable crops [1]. Triggered by the lack of productivity, outdated machinery and issues in bulk purchasing systems, problems of adaption to new emerging markets occurred. All these issues led to a drastic rise in terms of vine cultivation costs [31, 35]. Some producers terminated their production ultimately or shifted to new industries. Since the early 1990s (with an interruption due to the financial crisis), the grape-growing sector slowly has recovered in terms of production numbers, mainly because of an upswing in the brandy sector.
For brandy production, mainly white grape varieties, which can deliver higher yields and sugar levels (to obtain higher alcohol content for brandy making), are cultivated. Those varieties are less suitable for table wine production. Red varieties are mostly used for table wine production, where, in addition to sugar level, healthiness and other quality aspects such as ripeness, acidity and pH level are more important. Therefore, prices between red and white grapes are tremendously different—white grapes receive overall lower payments [1].
Producers purchase mostly grapes from small rural households with small average sizes of grape-growing units leaving the grape growers in a weak spot for bargaining. According to Hanf et al., most of the grape-buying agreements (besides YBC contracts) in the wine and brandy industry are based on quantity and trust [10]. They do not include quality criteria. Currently, informal, 1-year oral agreements are usually closed before harvest, but mostly repetitive during the years. The case of not observed contracts was also found in Armenia and has led to mistrust [10].
In 2017, overall, 66,544 farmers cultivated grapes in an average plot size of 0.23 ha [36]. Due to their plot sizes, many smallholders cannot manage to finance their winemaking facilities and/or get access to the market to sell the high-valued final product. That is why farmers are heavily dependent on their grape sales to a few operating production plants such as wineries or brandy factories [1]. The dependence on grape sale for smallholders is still high, as it is the primary source of rural income.
The YBC is (still) the leading brandy-producing enterprise of Armenia. Currently, the YBC has around 2500 private farmers delivering grapes to the company on a contract basis. It produces a range of brandies of different ages. The brand Ararat belongs to the company. The YBC exports up to 90% of the production to 33 countries worldwide. The primary export destination is Russia. The company comprises four production sites, in three grapes are received, the juice is fermented, and the interim product (wine) is distilled. In all four sites, the distillate is aged. The fourth site is in Yerevan, where the ageing, blending and bottling facilities as well as other divisions such as HR, IT, accountancy and administration are situated. The YBC has branches in Ararat, Armavir and Tavush.
To gain insights into the production structures, operational procedures and business relationship to the smallholders which supply grapes to the company, a qualitative research approach was chosen. Qualitative research is dedicated to a limited number of cases that are investigated as precisely as possible. Therefore, face-to-face individual interviews were conducted with different industry participants. Besides representatives of the company itself, we interviewed smallholders (grape producers) and industry experts from politics and education as well as experts from foreign help organisations, e.g. Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), Center for Agribusiness and Rural Development (CARD), Centre for the Promotion of Imports (CBI) from developing countries, etc. Additionally, we interviewed the director of the Vine and Wine Foundation of Armenia, who represents all grape growers and processors in the industry. Regarding the company’s perspective, we interviewed the heads of grape purchasing and quality control at the YBC and two of the YBC agronomists, who work directly together with the farmers in the vineyards. Moreover, we conducted interviews with 15 smallholders who have a contract with the company. To cover all production sites of the YBC, we have interviewed five farmers from each region. Some of the farmers have worked with the YBC for many years, and others have just recently started the collaboration. Interviews are based on a semi-structured interview guideline and were carried out by the authors personally. The interviews took place between May 2018 and January 2020. The interviews were conducted in Armenian and then translated into English to guarantee full exploitation of information.
For the qualitative analysis of the interviews, the approach of Gläser and Laudel [37] was used. They use a method called extractive qualitative content analysis. It is based on a structuring technique to extract relevant and complex information during the whole process. The process is completely open for new and unexpected information. After the information is extracted from the original text material (transcribed interviews), the information is processed and analysed.
The case study of the YBC shows how an international company manages to integrate local smallholders (grape growers) into their national and international value chains by using means of vertical coordination in the form of contracting. Moreover, the case study demonstrates how a procurement system can be installed successfully in a weak institutional setting. The YBC was the first company in Armenia to introduce the contracting system between the grape growers and processors in 2003. Later it was recognised by the government as an exemplary one.
After the Yerevan Brandy Company became part of the Pernod Ricard Group in 1998, an internal restructuring process has taken place to tackle the issues of the brandy industry and to align them with the international standards of the markets. Main changes were carried out in infrastructure, refurbishment, huge investments specifically in winemaking facilities and distilleries were made, but the most important changes were made in business management. The introduction of the first written, enforceable and long-term contracts changed the standards of the wine and brandy industry in Armenia.
The main reason why the YBC entered into contracting was to ensure sustainable grape supply in terms of quantity. To secure the needed quantity, the company has to purchase all their grapes from independent grape growers, as the YBC does not possess a large area of own vineyards except for 0.5 ha of trial vineyard. The company is forced to include smallholders to ensure the required quantity.
The contract, which is set up between the company and the grape growers, contains specifically the grape quantity, variety, contract length, characteristics of the plot where the grapes are grown and a few quality criteria such as the healthiness of the grapes and the minimum sugar level. One interviewed grape grower mentioned, for instance: “It is required to deliver healthy grapes. The delivered quantity should contain the smallest possible amount of material other than grapes (e.g. leaves, stones). The contract also includes the grape varieties which can be delivered to the company”. The guaranteed quantity enables grape growers to plan in terms of income, input supplies and production. Through the long-lasting approach (3–5 years of contracting), trust is built between both parties. As one interview partner said: “For me it’s not only the profit that matters. Most important is the long-term collaboration with the YBC, as it gives me a feeling of stability”. The interviewed farmers stated that the duration of the long-term contracts in the past was even 7 years.
Furthermore, the contract includes terms of payments and delivery (e.g. number and time of payments). All types of contracts include minimal prices. The company philosophy aims to purchase grapes at a price above the farmer’s production cost, which is company-wide evaluated before harvest.
In general, the price is announced in spring, which gives farmers the possibility to decide what to do. However, in some exceptional years (e.g. 2018) pricing details can vary, so the YBC announces the updated price before the harvest. As prices are included in the contracts and the contracts are legally enforceable, neither the farmer nor the YBC can negotiate on prices after the contract has been set up.
An annex of the contract takes into account the potential deviation from the contractual agreements due to quantity fluctuations. In August, shortly before the harvest starts, the YBC agronomists visit the vineyards and calculate the potential yield. If weather conditions were unfavourable and the farmer could not obtain the required quantity (or, in turn, the yield is higher than expected), the agronomists and farmers can fix the required quantity according to the situation. A grape grower stated: “The yield is always predicted by the agronomists beforehand. Depending on year the quantities can be higher or lower, but it is negotiable by the contract annex”.
Ten agronomists are working at the YBC doing quality control within the contracted vineyards to provide consultancy to the farmers. One of the farmers, for instance, said: “There was a time we were implementing old cultivation methods damaging our crop. In the beginning it was difficult to change our mind-set and follow the instructions of the YBC agronomists. Time proved the effectiveness of their consultancy so we became more open to their suggestions, even more motivated to find out new information, learn new cultivation technologies”. The consultancy includes good agricultural practices such as pruning, canopy management, spraying times with herbicides/pesticides, greenings, etc. Additionally, the agronomists also conduct monitoring to make sure that the expected grape quality and yield are going to be received. Based on the evaluation of the agronomists, the company subsidises smallholders with farm input assistance—if needed—with pesticides, herbicides and fertilisers. Another grape grower mentioned: “The company provides tools, sprayers, and pesticides at convenient prices. The payment for these inputs is directly taken out from the pay-out we receive for the delivered grapes”.
To provide knowledge and new techniques, the YBC owns 0.5 ha of experimental plots for trials. For instance, in 2006 the company started some trials on their experimental plots together with the Pernod Ricard research centre, to demonstrate their grape suppliers that new cultivation methods in the grape production can be less time-consuming and more profitable.
For smallholders, the main motivating factors to enter into contracts with the YBC are based on the benefits the farmers receive from working with the company. The YBC provides constant market access for grapes and gives the smallholders a guarantee of grape purchase. Farmers who do not breach the contract have a stable, reliable and almost predictable profit/income. The long-term relationship between the company and the farmers offers the opportunity to build trust between the contracting parties. This increases reliability between them and gives income security to the farmers. Besides some 1-year contracts, mostly 3–5 years of contract length (if there is no contract breach), are used. Another advantage is that grape delivery and payments are scheduled ahead; hence, no price negotiations of the YBC are possible if the farmer meets the contract requirement due to legal enforcement. The company provides farm assistance in the form of inputs (chemicals, fertilisers, etc.) and consultancy (pruning, irrigation, spraying times, dosage and frequency, etc.), if necessary. Farmers have access to knowledge and new techniques through the YBC. Grape producers also benefit from working with the YBC because they are delivering high-quality grapes for high-quality brandy production and thus benefit of the company’s reputation.
One of the smallholders, for example, said as a concluding remark: “My father and I were practicing grape cultivation ever since land privatisation in Armenia. We had a small plot and low quantities. Slowly, gaining experience in this field, our expectations rose, and at the same time, the vineyard territories expanded, especially in the period when PR bought the YBC and we started collaboration. The organizational skills of the company positively surprised us from the very beginning. It was the first time in Armenia, when the farmer delivers the grapes without being stuck in huge queue. Everything was planned with a contract”.
If it comes to the credit situation of the smallholders, the YBC is not helping them directly by providing loans, loan guarantees or trade credits. However, smallholders who work with the YBC over a longer period increase their chances to get a credit or loan at external institutions because of the fixed, long-term contracts with the YBC and, hence, a stable and enhanced profitability or improved future cash flows based on their past performances. This provides security to external institutions, improving the probability for smallholders to finance investments. One statement of an interviewed grape grower was: “Having larger vineyards, one always needs financial support to do investments in, for example, the trellising system (metal wires, etc.). Recently I expanded my vineyard and needed a bank loan. When applying for the loan the bank considers your current economic situation as well as where you are trading your product. Seeing our contract with a serious company such as the YBC, the bank never rejects the application”. In this setting, the YBC helps indirectly with access to capital.
In case a farmer cannot deliver the settled quality and/or quantity of grapes to the YBC, the contract is breached. Additionally, the competition among smallholders to work with the YBC is huge, creating societal pressure to follow the restrictions.
The contract design, as mentioned above, shows that the YBC is on the one hand working with marketing contracts to secure grape quantities and qualities for their brandy production. In general, the brandy production itself does not require highly differentiated grapes. Grape quality is mainly defined by a minimum sugar level and a minimum of the healthiness of grapes close to the harvest. However, the YBC sets up higher-quality restrictions. For instance, the company only purchases high-level healthy grapes (pest-free, disease-free, no foreign bodies, etc.) and certain grape varieties. The YBC does not purchase all grape varieties which can be used for brandy production.
In contrast to that, grape production for wine is more differentiated, and quality is also defined by sugar and healthiness, but it includes further grape characteristics such as colour, tannins and sugar and acid ratios. However, if we consider on the other hand the provided farm input assistance in the form of chemicals, fertilisers, etc. and the consultancy, e.g., pruning, irrigation and spraying times, this depicts a high involvement during the production process. The YBC actively engages in many critical decisions within the production process, adding production contract features.
Further interviews with some producers of table wine and experts from related fields such as education, politics and related fields/companies were conducted additionally. The interviews revealed that after the successful implementation of contracts in the brandy sector, many table wine producers followed. One of the experts stated: “Most of the time grape purchases for table wine were based on customary rearrangements. In that area a very well developed relationship, only one company has. This is Yerevan Brandy Company, having written contracts with their farmers. In this sense, Yerevan Brandy was a role model”. Another expert added that within the last years, a steady increase in contracts in the grape purchase was notable. Overall, the influence of the YBC in the brandy and wine sector of Armenia was shown.
Figure 4 sums up the results of vertical coordination mechanisms used in the productive partnerships of the YBC and the grape growers.
Results of vertical coordination in the YBC case study.
As a result of land privatisation which was part of the transition process, the average plot sizes of farmers are small. In 2017, overall, 66,544 farmers cultivated grapes in an average plot size of 0.23 ha. Due to their plot sizes, many smallholders cannot manage to finance their winemaking facilities and/or get access to the market to sell the high-valued final product, resulting in a high dependency of smallholders on grape sales to processors. In this context, the aim was to show how to integrate smallholders into national and international value chains by successfully installing a procurement system in weak institutional environments. In our case study of the Yerevan Brandy Company, we found that the company uses specification contracts as one type of vertical coordination, where independent individuals or firms of different stages in the value chain decide to collaborate. Currently, the YBC has around 2500 private farmers delivering grapes to the company on a contract basis. In order to avoid the disruptions in supply and inferior quality, the company introduced contracting from the early beginning. As a result, major disruptions in quantity and quality never occurred.
In 1998, Pernod Ricard Group bought the Yerevan Brandy Company, the most important Armenian brandy-producing company known by its Ararat brandy. This was when the first contracts between producers and smallholders were introduced. The YBC serves as a role model for other post-Soviet countries with similar issues up to the present.
Introducing the contracting system Yerevan Brandy Company reached a synchronisation of successive stages in the vertical marketing channel from producers to consumers to overcome problems of supply and quality. The YBC is taking different measures regarding vertical coordination. For example, the company uses mostly 3- to 5-year contracts, which include specifications of the grape quantity, variety, contract length, characteristics of the plot where the grapes are grown and a few quality criteria such as the healthiness of the grapes and the minimum sugar level. This shows that the YBC uses production contracts rather than pure marketing contracts. The company also offers farm assistance in the form of consultancy of YBC agronomists who closely work together with the farmers in the vineyards and in the form of input supply. Agronomists provide consultancy for viticultural practices, special viticultural issues, measures to take if yields are lower or higher than expected and input supply. The example of the YBC also shows that foreign direct investment not only brings capital, production facilities and technology transfers but also creates employment, provokes new job skills and offers management expertise.
The business environment in Armenia should embrace and reduce the obstacles for foreign companies to make investments in Armenia. This opens the opportunity for domestic producers to benefit financially, knowledge- and technology-wise, access to export markets as well as in business management from foreign direct investments.
In addition, the legal framework has to be improved to guarantee the enforcement of contracts and oral agreements. Especially grape growers, who are in a weak bargaining spot, would benefit from a legal improvement. Furthermore, NGOs or the ministry of agriculture could provide contract templates to reduce the numbers of oral agreements, as the legal setting for written contracts is more developed and enforcement exists.
The study finds that the institutional arrangements used in Armenia in the form of contract farming as part of vertical coordination are beneficial for both the processing company and the smallholders. In these contracts, the farmers agree to produce and supply agreed quantities of grapes. The study could not find any disadvantage for smallholders in terms of contract farming. In contrast, farmers who have a contract with the YBC benefit of secured market access, secured and stable income, access to bank loans, education, farm assistance in the form of consultancy or input supply.
For farmers who are not working with the YBC, a general recommendation is a higher financial support from the government or other institutions, which would help to ease their situation. The financial support in forms of credits or loans enables the grape growers to invest into more demanded varieties (e.g. red grapes for table winemaking) or even into other crops (e.g. lemons, peaches) which are more profitable.
Another option to support smallholders is the establishment of cooperatives. Cooperatives are beneficial for smallholders, as the bundling of quantities improves their bargain situation and knowledge—as well as investment—sharing is possible. The delivered grapes can be divided into quality categories, which then can be sold in different price segments to different market participants. The offer of differentiated quality levels with different prices leads to higher overall profits. Farmers who produce high-quality grapes gain higher patronage, giving an incentive for high-quality production. If wine or brandy producers need grapes or wine, they can bargain with the cooperative as a single entity for their needed quality category, and they do not have to bargain with many farmers to gain the same quantity.
All in all, the YBC manages to integrate smallholders (grape growers) into their national and international value chains by successfully installing a procurement system by using different measures of vertical coordination. Additionally, the YBC contributed to the development of the sector. Other companies start to adapt and take the YBC as a role model. In future, the standards set by the YBC and the ongoing development (education, knowledge, experience, etc.) will improve the performance of many farmers and equalise the produced qualities on the market. Sugar levels, healthiness of the grapes and usage of certain grape varieties become basic quality requirements. When the higher-quality products become standardised (e.g. IFS or GlobalGAP certified), mainly marketing contracts will be used. Thus, in the long run, it can be assumed that the degree of vertical coordination will decrease and the contracts will further tend towards pure marketing contracts. However, in the short and medium term, the adjustment will assumingly be rather slow.
Edited by Jan Oxholm Gordeladze, ISBN 978-953-51-3020-8, Print ISBN 978-953-51-3019-2, 336 pages,
\nPublisher: IntechOpen
\nChapters published March 22, 2017 under CC BY 3.0 license
\nDOI: 10.5772/61430
\nEdited Volume
This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\\n\\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\\n\\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\\n\\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\\n\\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\\n\\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\\n\\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\\n\\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\\n\\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\\n\\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\\n\\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\\n\\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
\\n"}]'},components:[{type:"htmlEditorComponent",content:'This book serves as a comprehensive survey of the impact of vitamin K2 on cellular functions and organ systems, indicating that vitamin K2 plays an important role in the differentiation/preservation of various cell phenotypes and as a stimulator and/or mediator of interorgan cross talk. Vitamin K2 binds to the transcription factor SXR/PXR, thus acting like a hormone (very much in the same manner as vitamin A and vitamin D). Therefore, vitamin K2 affects a multitude of organ systems, and it is reckoned to be one positive factor in bringing about "longevity" to the human body, e.g., supporting the functions/health of different organ systems, as well as correcting the functioning or even "curing" ailments striking several organs in our body.
\n\nChapter 1 Introductory Chapter: Vitamin K2 by Jan Oxholm Gordeladze
\n\nChapter 2 Vitamin K, SXR, and GGCX by Kotaro Azuma and Satoshi Inoue
\n\nChapter 3 Vitamin K2 Rich Food Products by Muhammad Yasin, Masood Sadiq Butt and Aurang Zeb
\n\nChapter 4 Menaquinones, Bacteria, and Foods: Vitamin K2 in the Diet by Barbara Walther and Magali Chollet
\n\nChapter 5 The Impact of Vitamin K2 on Energy Metabolism by Mona Møller, Serena Tonstad, Tone Bathen and Jan Oxholm Gordeladze
\n\nChapter 6 Vitamin K2 and Bone Health by Niels Erik Frandsen and Jan Oxholm Gordeladze
\n\nChapter 7 Vitamin K2 and its Impact on Tooth Epigenetics by Jan Oxholm Gordeladze, Maria A. Landin, Gaute Floer Johnsen, Håvard Jostein Haugen and Harald Osmundsen
\n\nChapter 8 Anti-Inflammatory Actions of Vitamin K by Stephen J. Hodges, Andrew A. Pitsillides, Lars M. Ytrebø and Robin Soper
\n\nChapter 9 Vitamin K2: Implications for Cardiovascular Health in the Context of Plant-Based Diets, with Applications for Prostate Health by Michael S. Donaldson
\n\nChapter 11 Vitamin K2 Facilitating Inter-Organ Cross-Talk by Jan O. Gordeladze, Håvard J. Haugen, Gaute Floer Johnsen and Mona Møller
\n\nChapter 13 Medicinal Chemistry of Vitamin K Derivatives and Metabolites by Shinya Fujii and Hiroyuki Kagechika
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Moreover, FIB sectioning and sampling techniques are frequently used for revealing the structural and morphological distribution of material systems with three-dimensional (3D) network at micro-/nanoscale.This book chapter includes many examples on conventional and novel processes of FIB technologies, ranging from analysis of semiconductors to electron tomography-based imaging of hard materials such as nanoporous ceramics and composites. In addition, recent studies concerning the active use of dual-beam platforms are mentioned",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Meltem Sezen",authors:[{id:"176338",title:"Associate Prof.",name:"Meltem",middleName:null,surname:"Sezen",slug:"meltem-sezen",fullName:"Meltem Sezen"}]},{id:"50866",title:"Effects of Different Laser Pulse Regimes (Nanosecond, Picosecond and Femtosecond) on the Ablation of Materials for Production of Nanoparticles in Liquid Solution",slug:"effects-of-different-laser-pulse-regimes-nanosecond-picosecond-and-femtosecond-on-the-ablation-of-ma",totalDownloads:6073,totalCrossrefCites:10,totalDimensionsCites:34,abstract:"Ultra-short laser pulse interaction with materials has received much attention from researchers in micro- and nanomachining, especially for the generation of nanoparticles in liquid environments, because of the straightforward method and direct application for organic solvents. In addition, the colloidal nanoparticles produced by laser ablation have very high purity—they are free from surfactants and reaction products or by-products. In this chapter, nanosecond, picosecond and femtosecond laser pulse durations are compared in laser material processing. Due to the unique properties of the short and ultra-short laser pulse durations in material processing, they are more apparent in the production of precision material processing and generation of nanoparticles in liquid environments.",book:{id:"5236",slug:"high-energy-and-short-pulse-lasers",title:"High Energy and Short Pulse Lasers",fullTitle:"High Energy and Short Pulse Lasers"},signatures:"Abubaker Hassan Hamad",authors:[{id:"183494",title:"Dr.",name:"Abubaker",middleName:"Hassan",surname:"Hamad",slug:"abubaker-hamad",fullName:"Abubaker Hamad"}]},{id:"49537",title:"Electron Diffraction",slug:"electron-diffraction",totalDownloads:10111,totalCrossrefCites:10,totalDimensionsCites:31,abstract:"Electron microscopes are usually supplied with equipment for obtaining diffraction patterns and micrographs from the same area of a specimen and the best results are attained if the complete use is to be made of these combined facilities. Electron diffraction patterns are used to obtain quantitative data including phase identification, orientation relationship and crystal defects in materials, etc. At first, a general introduction including a geometrical and quantitative approach to electron diffraction from a crystalline specimen, the reciprocal lattice and electron diffraction in the electron microscope are presented. The scattering process by an individual atom as well as a crystal, the Bragg law, Laue conditions and structure factor are also discussed. Types of diffraction patterns such as ring pattern, spot pattern and Kikuchi pattern, and general and unique indexing diffraction patterns are explained. The procedure for indexing simple, complicated and imperfect patterns as well as Kikuchi lines and a combination of Kikuchi lines and spots is outlined. The known and unknown materials are identified by indexing patterns. Practical comparisons between various methods of analysing diffraction patterns are also described. The basic diffraction patterns and the fine structure in the patterns including specimen tilting experiments, orientation relationship determination, phase identification, twinning, second phases, crystallographic information, dislocation, preferred orientation and texture, extra spots and streaks are described in detail. Finally, electron diffraction patterns of new materials are investigated.",book:{id:"5075",slug:"modern-electron-microscopy-in-physical-and-life-sciences",title:"Modern Electron Microscopy in Physical and Life Sciences",fullTitle:"Modern Electron Microscopy in Physical and Life Sciences"},signatures:"Mohsen Asadi Asadabad and Mohammad Jafari Eskandari",authors:[{id:"176352",title:"Dr.",name:"Mohsen",middleName:null,surname:"Asadi Asadabad",slug:"mohsen-asadi-asadabad",fullName:"Mohsen Asadi Asadabad"},{id:"177600",title:"Dr.",name:"Mohammad",middleName:null,surname:"Jafari Eskandari",slug:"mohammad-jafari-eskandari",fullName:"Mohammad Jafari Eskandari"}]}],onlineFirstChaptersFilter:{topicId:"20",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82228",title:"Nonlinear Intelligent Predictive Control for the Yaw System of Large-Scale Wind Turbines",slug:"nonlinear-intelligent-predictive-control-for-the-yaw-system-of-large-scale-wind-turbines",totalDownloads:9,totalDimensionsCites:0,doi:"10.5772/intechopen.105484",abstract:"This chapter presents a nonlinear intelligent predictive control using multi-step prediction model for the electrical motor-based yaw system of an industrial wind turbine. The proposed method introduces a finite control set under constraints for the demanded yaw rate, predicts the multi-step yaw error using the control set element and the prediction wind directions, and employs an exhaustive search method to search the control output candidate giving the minimal value of the objective function. As the objective function is designed for a joint power and actuator usage optimization, the weighting factor in the objective function is optimally determined by the fuzzy regulator that is optimized by an intelligent algorithm. Finally, the proposed method is demonstrated by simulation tests using real wind direction data.",book:{id:"11499",title:"Nonlinear Systems - Recent Developments and Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11499.jpg"},signatures:"Dongran Song, Ziqun Li, Jian Yang, Mi Dong, Xiaojiao Chen and Liansheng Huang"},{id:"82102",title:"Vortex Analysis and Fluid Transport in Time-Dependent Flows",slug:"vortex-analysis-and-fluid-transport-in-time-dependent-flows",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105196",abstract:"In this contribution, we present a set of procedures developed to identify fluid flow structures and characterize their space-time evolution in time-dependent flows. In particular, we consider two different contests of importance in applied fluid mechanics: 1) large-scale almost 2D atmospheric and oceanic flows and 2) flow inside the left ventricle in the human blood circulation. For both cases, we designed an ad hoc experimental model to reproduce and deeply investigate the considered phenomena. We will focus on the post-processing of high-resolution velocity data sets obtained via laboratory experiments by measuring the flow field using a technique based on image analysis. We show how the proposed methodologies represent a valid tool suitable for extracting the main patterns and quantify fluid transport in complex flows from both Eulerian and Lagrangian perspectives.",book:{id:"10958",title:"Vortex Dynamics - From Physical to Mathematical Aspects",coverURL:"https://cdn.intechopen.com/books/images_new/10958.jpg"},signatures:"Stefania Espa, Maria Grazia Badas and Simon Cabanes"},{id:"82222",title:"High-Lying Confined Subbands in Terahertz Quantum Cascade Lasers",slug:"high-lying-confined-subbands-in-terahertz-quantum-cascade-lasers",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.105479",abstract:"In designing the terahertz quantum cascade lasers, electron injection manner indeed plays a significant role to achieve the population inversion. The resonant tunneling process is commonly employed for this injection process but waste more than 50% fraction of populations out of the active region owing to resonance alignment, and the injection efficiency is obviously degraded due to thermal incoherence. An alternative approach is to consider the phonon-assisted injection process that basically contributes to most of the populations to the upper lasing level. However, this manner is still not realized in experiments if a short-period design only containing two quantum wells is used. In this work, it is found in this design that the population inversion is indeed well improved; however, the optical gain is inherently low even at a low temperature. Those two opposite trends are ascribed to a strong parasitic absorption overlapping the gain. The magnitude of this overlap is closely related to the lasing frequency, where frequencies below 3 THz suffer from fewer effects.",book:{id:"11495",title:"Fundamentals and Application of Femtosecond Optics",coverURL:"https://cdn.intechopen.com/books/images_new/11495.jpg"},signatures:"Li Wang"},{id:"82149",title:"Colorimetric Evaluations and Characterization of Natural and Synthetic Dyes/Pigments and Dyed Textiles and Related Products",slug:"colorimetric-evaluations-and-characterization-of-natural-and-synthetic-dyes-pigments-and-dyed-textil",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104774",abstract:"This book chapter covers principles and few case studies on colorimetric Estimation of (i) determining purity/active ingredient % of selective dyes/pigments (ii) Identification of any colorants to distinguish from other similar compound, (iii) Measurement of surface colour strength of a dyed textile, (iv) Measurement of colour differences by estimating DE, DL*, Da*, Db*, DC and DH values, (v)Computer-aided colour match prediction for any standard shades, (vi) Estimation of compatibility of two dyes/colourants to use for compound shades, (vii) Determination of rate of dyeing, dyeing isotherm and dyeing kinetics to control dyeing, (viii) Optimization of dyeing process variables, (ix) Precession grading of Colour Fastness of dyed textiles on fading under different ways/agencies and (x) Estimation of Soil Removal efficacy of different detergent used for textiles. These colorimetric measurements are found to be very useful for effective process and product control of dyed textile materials. Selected Case studies on all the above colorimetric applications with specific example or experimented data are discussed for each of the method under reference. Finally, the other applications of colorimetric analysis besides textiles industry are also mentioned in concluding remarks.",book:{id:"11002",title:"Colorimetry",coverURL:"https://cdn.intechopen.com/books/images_new/11002.jpg"},signatures:"Ashis Kumar Samanta"},{id:"82116",title:"Thermo-Rheological Effect on Weak Nonlinear Rayleigh-Benard Convection under Rotation Speed Modulation",slug:"thermo-rheological-effect-on-weak-nonlinear-rayleigh-benard-convection-under-rotation-speed-modulati",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.105097",abstract:"The effects of rotation speed modulation and temperature-dependent viscosity on Rayleigh-Benard convection were investigated using a non-autonomous Ginzburg-Landau equation. The rotating temperature-dependent viscous fluid layer has been considered. The momentum equation with the Coriolis term has been used to describe finite-amplitude convective flow. The system is considered to be rotating about its vertical axis with a non-uniform rotation speed. In particular, we assume that the rotation speed is varying sinusoidally with time. Nusselt number is obtained in terms of the system parameters and graphically evaluated their effects. The effect of the modulated system diminishes the heat transfer more than the un-modulated system. Further, thermo-rheological parameter VT is found to destabilize the system.",book:{id:"11498",title:"Boundary Layer Flows - Modelling, Computation, and Applications of Laminar, Turbulent Incompressible and Compressible Flows",coverURL:"https://cdn.intechopen.com/books/images_new/11498.jpg"},signatures:"S.H. Manjula and Palle Kiran"},{id:"81712",title:"Atomic Force Microscope in Forensic Examination",slug:"atomic-force-microscope-in-forensic-examination",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104704",abstract:"Criminal activities have their footprints from time immemorial and nature of crime has drastically changed over a period of time. There is neither a geographical boundary, nor technical limitations. Moreover terrorist’s activities, drug trafficking eco-crimes, high-profile crimes, robbery hit and run cases, building collapse, petroleum products adulteration are some of latest forms of crimes. In last 20 years, scanning probe microscopes have emerged as an essential technique in various fields, and atomic force microscope (AFM) is most commonly used scanning probe technique which has shown its wide range of application in examination of various evidences encountered on crime scene. Major advantages of AFM involve its high resolution in three dimensions, and sample is not necessary to be conductive and it does not need to be operated within a vacuum. It helps in studying a large range of topographies and many types of materials can be imaged under it. Evidences such as blood, fibers, hair, soil, finger prints, gunshot residue, pollen, etc. found on crime scene at nano- or micro-level can be examined under AFM. The chapter describes applications of AFM with respect to its application in examination of evidences that can help in bringing justice.",book:{id:"11146",title:"Electron Microscopy",coverURL:"https://cdn.intechopen.com/books/images_new/11146.jpg"},signatures:"Niha Ansari"}],onlineFirstChaptersTotal:38},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:89,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:318,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:106,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:15,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"June 11th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"38",title:"Pollution",coverUrl:"https://cdn.intechopen.com/series_topics/covers/38.jpg",isOpenForSubmission:!0,editor:{id:"110740",title:"Dr.",name:"Ismail M.M.",middleName:null,surname:"Rahman",slug:"ismail-m.m.-rahman",fullName:"Ismail M.M. Rahman",profilePictureURL:"https://mts.intechopen.com/storage/users/110740/images/2319_n.jpg",biography:"Ismail Md. Mofizur Rahman (Ismail M. M. Rahman) assumed his current responsibilities as an Associate Professor at the Institute of Environmental Radioactivity, Fukushima University, Japan, in Oct 2015. He also has an honorary appointment to serve as a Collaborative Professor at Kanazawa University, Japan, from Mar 2015 to the present. \nFormerly, Dr. Rahman was a faculty member of the University of Chittagong, Bangladesh, affiliated with the Department of Chemistry (Oct 2002 to Mar 2012) and the Department of Applied Chemistry and Chemical Engineering (Mar 2012 to Sep 2015). Dr. Rahman was also adjunctly attached with Kanazawa University, Japan (Visiting Research Professor, Dec 2014 to Mar 2015; JSPS Postdoctoral Research Fellow, Apr 2012 to Mar 2014), and Tokyo Institute of Technology, Japan (TokyoTech-UNESCO Research Fellow, Oct 2004–Sep 2005). \nHe received his Ph.D. degree in Environmental Analytical Chemistry from Kanazawa University, Japan (2011). He also achieved a Diploma in Environment from the Tokyo Institute of Technology, Japan (2005). Besides, he has an M.Sc. degree in Applied Chemistry and a B.Sc. degree in Chemistry, all from the University of Chittagong, Bangladesh. \nDr. Rahman’s research interest includes the study of the fate and behavior of environmental pollutants in the biosphere; design of low energy and low burden environmental improvement (remediation) technology; implementation of sustainable waste management practices for treatment, handling, reuse, and ultimate residual disposition of solid wastes; nature and type of interactions in organic liquid mixtures for process engineering design applications.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorTwo:{id:"201020",title:"Dr.",name:"Zinnat Ara",middleName:null,surname:"Begum",slug:"zinnat-ara-begum",fullName:"Zinnat Ara Begum",profilePictureURL:"https://mts.intechopen.com/storage/users/201020/images/system/201020.jpeg",biography:"Zinnat A. Begum received her Ph.D. in Environmental Analytical Chemistry from Kanazawa University in 2012. She achieved her Master of Science (M.Sc.) degree with a major in Applied Chemistry and a Bachelor of Science (B.Sc.) in Chemistry, all from the University of Chittagong, Bangladesh. Her work affiliations include Fukushima University, Japan (Visiting Research Fellow, Institute of Environmental Radioactivity: Mar 2016 to present), Southern University Bangladesh (Assistant Professor, Department of Civil Engineering: Jan 2015 to present), and Kanazawa University, Japan (Postdoctoral Fellow, Institute of Science and Engineering: Oct 2012 to Mar 2014; Research fellow, Venture Business Laboratory, Advanced Science and Social Co-Creation Promotion Organization: Apr 2018 to Mar 2021). The research focus of Dr. Zinnat includes the effect of the relative stability of metal-chelator complexes in the environmental remediation process designs and the development of eco-friendly soil washing techniques using biodegradable chelators.",institutionString:null,institution:{name:"Fukushima University",institutionURL:null,country:{name:"Japan"}}},editorThree:null},{id:"39",title:"Environmental Resilience and Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/39.jpg",isOpenForSubmission:!0,editor:{id:"137040",title:"Prof.",name:"Jose",middleName:null,surname:"Navarro-Pedreño",slug:"jose-navarro-pedreno",fullName:"Jose Navarro-Pedreño",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRAXrQAO/Profile_Picture_2022-03-09T15:50:19.jpg",biography:"Full professor at University Miguel Hernández of Elche, Spain, previously working at the University of Alicante, Autonomous University of Madrid and Polytechnic University of Valencia. Graduate in Sciences (Chemist), graduate in Geography and History (Geography), master in Water Management, Treatment, master in Fertilizers and Environment and master in Environmental Management; Ph.D. in Environmental Sciences. His research is focused on soil-water and waste-environment relations, mainly on soil-water and soil-waste interactions under different management and waste reuse. His work is reflected in more than 230 communications presented in national and international conferences and congresses, 29 invited lectures from universities, associations and government agencies. Prof. Navarro-Pedreño is also a director of the Ph.D. Program Environment and Sustainability (2012-present) and a member of several societies among which are the Spanish Society of Soil Science, International Union of Soil Sciences, European Society for Soil Conservation, DessertNet and the Spanish Royal Society of Chemistry.",institutionString:"Miguel Hernández University of Elche, Spain",institution:null},editorTwo:null,editorThree:null},{id:"40",title:"Ecosystems and Biodiversity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/40.jpg",isOpenForSubmission:!0,editor:{id:"209149",title:"Prof.",name:"Salustiano",middleName:null,surname:"Mato",slug:"salustiano-mato",fullName:"Salustiano Mato",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRLREQA4/Profile_Picture_2022-03-31T10:23:50.png",biography:"Salustiano Mato de la Iglesia (Santiago de Compostela, 1960) is a doctor in biology from the University of Santiago and a Professor of zoology at the Department of Ecology and Animal Biology at the University of Vigo. He has developed his research activity in the fields of fauna and soil ecology, and in the treatment of organic waste, having been the founder and principal investigator of the Environmental Biotechnology Group of the University of Vigo.\r\nHis research activity in the field of Environmental Biotechnology has been focused on the development of novel organic waste treatment systems through composting. The result of this line of work are three invention patents and various scientific and technical publications in prestigious international journals.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorTwo:{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",slug:"josefina-garrido",fullName:"Josefina Garrido",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRj1VQAS/Profile_Picture_2022-03-31T10:06:51.jpg",biography:"Josefina Garrido González (Paradela de Abeleda, Ourense 1959), is a doctor in biology from the University of León and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. She has focused her research activity on the taxonomy, fauna and ecology of aquatic beetles, in addition to other lines of research such as the conservation of biodiversity in freshwater ecosystems; conservation of protected areas (Red Natura 2000) and assessment of the effectiveness of wetlands as priority areas for the conservation of aquatic invertebrates; studies of water quality in freshwater ecosystems through biological indicators and physicochemical parameters; surveillance and research of vector arthropods and invasive alien species.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}},editorThree:{id:"464288",title:"Dr.",name:"Francisco",middleName:null,surname:"Ramil",slug:"francisco-ramil",fullName:"Francisco Ramil",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003RI7lHQAT/Profile_Picture_2022-03-31T10:15:35.png",biography:"Fran Ramil Blanco (Porto de Espasante, A Coruña, 1960), is a doctor in biology from the University of Santiago de Compostela and a Professor of Zoology at the Department of Ecology and Animal Biology at the University of Vigo. His research activity is linked to the taxonomy, fauna and ecology of marine benthic invertebrates and especially the Cnidarian group. Since 2004, he has been part of the EcoAfrik project, aimed at the study, protection and conservation of biodiversity and benthic habitats in West Africa. He also participated in the study of vulnerable marine ecosystems associated with seamounts in the South Atlantic and is involved in training young African researchers in the field of marine research.",institutionString:null,institution:{name:"University of Vigo",institutionURL:null,country:{name:"Spain"}}}},{id:"41",title:"Water Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/41.jpg",isOpenForSubmission:!0,editor:{id:"349630",title:"Dr.",name:"Yizi",middleName:null,surname:"Shang",slug:"yizi-shang",fullName:"Yizi Shang",profilePictureURL:"https://mts.intechopen.com/storage/users/349630/images/system/349630.jpg",biography:"Prof. Dr. Yizi Shang is a pioneering researcher in hydrology and water resources who has devoted his research career to promoting the conservation and protection of water resources for sustainable development. He is presently associate editor of Water International (official journal of the International Water Resources Association). He was also invited to serve as an associate editor for special issues of the Journal of the American Water Resources Association. He has served as an editorial member for international journals such as Hydrology, Journal of Ecology & Natural Resources, and Hydro Science & Marine Engineering, among others. He has chaired or acted as a technical committee member for twenty-five international forums (conferences). Dr. Shang graduated from Tsinghua University, China, in 2010 with a Ph.D. in Engineering. Prior to that, he worked as a research fellow at Harvard University from 2008 to 2009. Dr. Shang serves as a senior research engineer at the China Institute of Water Resources and Hydropower Research (IWHR) and was awarded as a distinguished researcher at National Taiwan University in 2017.",institutionString:"China Institute of Water Resources and Hydropower Research",institution:{name:"China Institute of Water Resources and Hydropower Research",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:3,paginationItems:[{id:"82362",title:"Studies on the Short-Term Effects of the Cease of Pesticides Use on Vineyard Microbiome",doi:"10.5772/intechopen.105706",signatures:"Simona Ghiță, Mihaela Hnatiuc, Aurora Ranca, Victoria Artem and Mădălina-Andreea Ciocan",slug:"studies-on-the-short-term-effects-of-the-cease-of-pesticides-use-on-vineyard-microbiome",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}},{id:"82297",title:"The Climate Change-Agriculture Nexus in Drylands of Ethiopia",doi:"10.5772/intechopen.103905",signatures:"Zenebe Mekonnen",slug:"the-climate-change-agriculture-nexus-in-drylands-of-ethiopia",totalDownloads:19,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Vegetation Dynamics, Changing Ecosystems and Human Responsibility",coverURL:"https://cdn.intechopen.com/books/images_new/11663.jpg",subseries:{id:"40",title:"Ecosystems and Biodiversity"}}},{id:"81999",title:"Climate Change, Rural Livelihoods, and Human Well-Being: Experiences from Kenya",doi:"10.5772/intechopen.104965",signatures:"André J. 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He has both an MS and Ph.D. in Biomedical Engineering. He was previously a research scientist at the University of California Los Angeles (UCLA) and visiting professor and researcher at the University of North Dakota. He is currently working in artificial intelligence and its applications in medical signal processing. In addition, he is using digital signal processing in medical imaging and speech processing. Dr. Asadpour has developed brain-computer interfacing algorithms and has published books, book chapters, and several journal and conference papers in this field and other areas of intelligent signal processing. He has also designed medical devices, including a laser Doppler monitoring system.",institutionString:"Kaiser Permanente Southern California",institution:null},{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",biography:"Prof. Dr. Marian Gaiceanu graduated from the Naval and Electrical Engineering Faculty, Dunarea de Jos University of Galati, Romania, in 1997. He received a Ph.D. (Magna Cum Laude) in Electrical Engineering in 2002. Since 2017, Dr. Gaiceanu has been a Ph.D. supervisor for students in Electrical Engineering. He has been employed at Dunarea de Jos University of Galati since 1996, where he is currently a professor. Dr. Gaiceanu is a member of the National Council for Attesting Titles, Diplomas and Certificates, an expert of the Executive Agency for Higher Education, Research Funding, and a member of the Senate of the Dunarea de Jos University of Galati. He has been the head of the Integrated Energy Conversion Systems and Advanced Control of Complex Processes Research Center, Romania, since 2016. He has conducted several projects in power converter systems for electrical drives, power quality, PEM and SOFC fuel cell power converters for utilities, electric vehicles, and marine applications with the Department of Regulation and Control, SIEI S.pA. (2002–2004) and the Polytechnic University of Turin, Italy (2002–2004, 2006–2007). He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and cofounder-member of the IEEE Power Electronics Romanian Chapter. He is a guest editor at Energies and an academic book editor for IntechOpen. He is also a member of the editorial boards of the Journal of Electrical Engineering, Electronics, Control and Computer Science and Sustainability. Dr. Gaiceanu has been General Chairman of the IEEE International Symposium on Electrical and Electronics Engineering in the last six editions.",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',country:{name:"Romania"}}},{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",biography:"Jaydip Sen is associated with Praxis Business School, Kolkata, India, as a professor in the Department of Data Science. His research areas include security and privacy issues in computing and communication, intrusion detection systems, machine learning, deep learning, and artificial intelligence in the financial domain. He has more than 200 publications in reputed international journals, refereed conference proceedings, and 20 book chapters in books published by internationally renowned publishing houses, such as Springer, CRC press, IGI Global, etc. Currently, he is serving on the editorial board of the prestigious journal Frontiers in Communications and Networks and in the technical program committees of a number of high-ranked international conferences organized by the IEEE, USA, and the ACM, USA. He has been listed among the top 2% of scientists in the world for the last three consecutive years, 2019 to 2021 as per studies conducted by the Stanford University, USA.",institutionString:"Praxis Business School",institution:null},{id:"320071",title:"Dr.",name:"Sidra",middleName:null,surname:"Mehtab",slug:"sidra-mehtab",fullName:"Sidra Mehtab",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002v6KHoQAM/Profile_Picture_1584512086360",biography:"Sidra Mehtab has completed her BS with honors in Physics from Calcutta University, India in 2018. She has done MS in Data Science and Analytics from Maulana Abul Kalam Azad University of Technology (MAKAUT), Kolkata, India in 2020. Her research areas include Econometrics, Time Series Analysis, Machine Learning, Deep Learning, Artificial Intelligence, and Computer and Network Security with a particular focus on Cyber Security Analytics. Ms. Mehtab has published seven papers in international conferences and one of her papers has been accepted for publication in a reputable international journal. She has won the best paper awards in two prestigious international conferences – BAICONF 2019, and ICADCML 2021, organized in the Indian Institute of Management, Bangalore, India in December 2019, and SOA University, Bhubaneswar, India in January 2021. Besides, Ms. Mehtab has also published two book chapters in two books. Seven of her book chapters will be published in a volume shortly in 2021 by Cambridge Scholars’ Press, UK. Currently, she is working as the joint editor of two edited volumes on Time Series Analysis and Forecasting to be published in the first half of 2021 by an international house. Currently, she is working as a Data Scientist with an MNC in Delhi, India.",institutionString:"NSHM College of Management and Technology",institution:null},{id:"226240",title:"Dr.",name:"Andri Irfan",middleName:null,surname:"Rifai",slug:"andri-irfan-rifai",fullName:"Andri Irfan Rifai",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226240/images/7412_n.jpg",biography:"Andri IRFAN is a Senior Lecturer of Civil Engineering and Planning. He completed the PhD at the Universitas Indonesia & Universidade do Minho with Sandwich Program Scholarship from the Directorate General of Higher Education and LPDP scholarship. He has been teaching for more than 19 years and much active to applied his knowledge in the project construction in Indonesia. His research interest ranges from pavement management system to advanced data mining techniques for transportation engineering. He has published more than 50 papers in journals and 2 books.",institutionString:null,institution:{name:"Universitas Internasional Batam",country:{name:"Indonesia"}}},{id:"314576",title:"Dr.",name:"Ibai",middleName:null,surname:"Laña",slug:"ibai-lana",fullName:"Ibai Laña",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314576/images/system/314576.jpg",biography:"Dr. Ibai Laña works at TECNALIA as a data analyst. He received his Ph.D. in Artificial Intelligence from the University of the Basque Country (UPV/EHU), Spain, in 2018. He is currently a senior researcher at TECNALIA. His research interests fall within the intersection of intelligent transportation systems, machine learning, traffic data analysis, and data science. He has dealt with urban traffic forecasting problems, applying machine learning models and evolutionary algorithms. He has experience in origin-destination matrix estimation or point of interest and trajectory detection. Working with large volumes of data has given him a good command of big data processing tools and NoSQL databases. He has also been a visiting scholar at the Knowledge Engineering and Discovery Research Institute, Auckland University of Technology.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"314575",title:"Dr.",name:"Jesus",middleName:null,surname:"L. Lobo",slug:"jesus-l.-lobo",fullName:"Jesus L. Lobo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/314575/images/system/314575.png",biography:"Dr. Jesús López is currently based in Bilbao (Spain) working at TECNALIA as Artificial Intelligence Research Scientist. In most cases, a project idea or a new research line needs to be investigated to see if it is good enough to take into production or to focus on it. That is exactly what he does, diving into Machine Learning algorithms and technologies to help TECNALIA to decide whether something is great in theory or will actually impact on the product or processes of its projects. So, he is expert at framing experiments, developing hypotheses, and proving whether they’re true or not, in order to investigate fundamental problems with a longer time horizon. He is also able to design and develop PoCs and system prototypes in simulation. He has participated in several national and internacional R&D projects.\n\nAs another relevant part of his everyday research work, he usually publishes his findings in reputed scientific refereed journals and international conferences, occasionally acting as reviewer and Programme Commitee member. Concretely, since 2018 he has published 9 JCR (8 Q1) journal papers, 9 conference papers (e.g. ECML PKDD 2021), and he has co-edited a book. He is also active in popular science writing data science stories for reputed blogs (KDNuggets, TowardsDataScience, Naukas). Besides, he has recently embarked on mentoring programmes as mentor, and has also worked as data science trainer.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"103779",title:"Prof.",name:"Yalcin",middleName:null,surname:"Isler",slug:"yalcin-isler",fullName:"Yalcin Isler",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRyQ8QAK/Profile_Picture_1628834958734",biography:"Yalcin Isler (1971 - Burdur / Turkey) received the B.Sc. degree in the Department of Electrical and Electronics Engineering from Anadolu University, Eskisehir, Turkey, in 1993, the M.Sc. degree from the Department of Electronics and Communication Engineering, Suleyman Demirel University, Isparta, Turkey, in 1996, the Ph.D. degree from the Department of Electrical and Electronics Engineering, Dokuz Eylul University, Izmir, Turkey, in 2009, and the Competence of Associate Professorship from the Turkish Interuniversity Council in 2019.\n\nHe was Lecturer at Burdur Vocational School in Suleyman Demirel University (1993-2000, Burdur / Turkey), Software Engineer (2000-2002, Izmir / Turkey), Research Assistant in Bulent Ecevit University (2002-2003, Zonguldak / Turkey), Research Assistant in Dokuz Eylul University (2003-2010, Izmir / Turkey), Assistant Professor at the Department of Electrical and Electronics Engineering in Bulent Ecevit University (2010-2012, Zonguldak / Turkey), Assistant Professor at the Department of Biomedical Engineering in Izmir Katip Celebi University (2012-2019, Izmir / Turkey). He is an Associate Professor at the Department of Biomedical Engineering at Izmir Katip Celebi University, Izmir / Turkey, since 2019. In addition to academics, he has also founded Islerya Medical and Information Technologies Company, Izmir / Turkey, since 2017.\n\nHis main research interests cover biomedical signal processing, pattern recognition, medical device design, programming, and embedded systems. He has many scientific papers and participated in several projects in these study fields. He was an IEEE Student Member (2009-2011) and IEEE Member (2011-2014) and has been IEEE Senior Member since 2014.",institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"339677",title:"Dr.",name:"Mrinmoy",middleName:null,surname:"Roy",slug:"mrinmoy-roy",fullName:"Mrinmoy Roy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/339677/images/16768_n.jpg",biography:"An accomplished Sales & Marketing professional with 12 years of cross-functional experience in well-known organisations such as CIPLA, LUPIN, GLENMARK, ASTRAZENECA across different segment of Sales & Marketing, International Business, Institutional Business, Product Management, Strategic Marketing of HIV, Oncology, Derma, Respiratory, Anti-Diabetic, Nutraceutical & Stomatological Product Portfolio and Generic as well as Chronic Critical Care Portfolio. A First Class MBA in International Business & Strategic Marketing, B.Pharm, D.Pharm, Google Certified Digital Marketing Professional. Qualified PhD Candidate in Operations and Management with special focus on Artificial Intelligence and Machine Learning adoption, analysis and use in Healthcare, Hospital & Pharma Domain. Seasoned with diverse therapy area of Pharmaceutical Sales & Marketing ranging from generating revenue through generating prescriptions, launching new products, and making them big brands with continuous strategy execution at the Physician and Patients level. Moved from Sales to Marketing and Business Development for 3.5 years in South East Asian Market operating from Manila, Philippines. Came back to India and handled and developed Brands such as Gluconorm, Lupisulin, Supracal, Absolut Woman, Hemozink, Fabiflu (For COVID 19), and many more. In my previous assignment I used to develop and execute strategies on Sales & Marketing, Commercialization & Business Development for Institution and Corporate Hospital Business portfolio of Oncology Therapy Area for AstraZeneca Pharma India Ltd. Being a Research Scholar and Student of ‘Operations Research & Management: Artificial Intelligence’ I published several pioneer research papers and book chapters on the same in Internationally reputed journals and Books indexed in Scopus, Springer and Ei Compendex, Google Scholar etc. Currently, I am launching PGDM Pharmaceutical Management Program in IIHMR Bangalore and spearheading the course curriculum and structure of the same. I am interested in Collaboration for Healthcare Innovation, Pharma AI Innovation, Future trend in Marketing and Management with incubation on Healthcare, Healthcare IT startups, AI-ML Modelling and Healthcare Algorithm based training module development. I am also an affiliated member of the Institute of Management Consultant of India, looking forward to Healthcare, Healthcare IT and Innovation, Pharma and Hospital Management Consulting works.",institutionString:null,institution:{name:"Lovely Professional University",country:{name:"India"}}},{id:"310576",title:"Prof.",name:"Erick Giovani",middleName:null,surname:"Sperandio Nascimento",slug:"erick-giovani-sperandio-nascimento",fullName:"Erick Giovani Sperandio Nascimento",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y00002pDKxDQAW/ProfilePicture%202022-06-20%2019%3A57%3A24.788",biography:"Prof. Erick Sperandio is the Lead Researcher and professor of Artificial Intelligence (AI) at SENAI CIMATEC, Bahia, Brazil, also working with Computational Modeling (CM) and HPC. He holds a PhD in Environmental Engineering in the area of Atmospheric Computational Modeling, a Master in Informatics in the field of Computational Intelligence and Graduated in Computer Science from UFES. He currently coordinates, leads and participates in R&D projects in the areas of AI, computational modeling and supercomputing applied to different areas such as Oil and Gas, Health, Advanced Manufacturing, Renewable Energies and Atmospheric Sciences, advising undergraduate, master's and doctoral students. He is the Lead Researcher at SENAI CIMATEC's Reference Center on Artificial Intelligence. In addition, he is a Certified Instructor and University Ambassador of the NVIDIA Deep Learning Institute (DLI) in the areas of Deep Learning, Computer Vision, Natural Language Processing and Recommender Systems, and Principal Investigator of the NVIDIA/CIMATEC AI Joint Lab, the first in Latin America within the NVIDIA AI Technology Center (NVAITC) worldwide program. He also works as a researcher at the Supercomputing Center for Industrial Innovation (CS2i) and at the SENAI Institute of Innovation for Automation (ISI Automação), both from SENAI CIMATEC. He is a member and vice-coordinator of the Basic Board of Scientific-Technological Advice and Evaluation, in the area of Innovation, of the Foundation for Research Support of the State of Bahia (FAPESB). He serves as Technology Transfer Coordinator and one of the Principal Investigators at the National Applied Research Center in Artificial Intelligence (CPA-IA) of SENAI CIMATEC, focusing on Industry, being one of the six CPA-IA in Brazil approved by MCTI / FAPESP / CGI.br. He also participates as one of the representatives of Brazil in the BRICS Innovation Collaboration Working Group on HPC, ICT and AI. He is the coordinator of the Work Group of the Axis 5 - Workforce and Training - of the Brazilian Strategy for Artificial Intelligence (EBIA), and member of the MCTI/EMBRAPII AI Innovation Network Training Committee. He is the coordinator, by SENAI CIMATEC, of the Artificial Intelligence Reference Network of the State of Bahia (REDE BAH.IA). He leads the working group of experts representing Brazil in the Global Partnership on Artificial Intelligence (GPAI), on the theme \"AI and the Pandemic Response\".",institutionString:"Manufacturing and Technology Integrated Campus – SENAI CIMATEC",institution:null},{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",biography:"Prof. Dr. Constantin Voloşencu graduated as an engineer from\nPolitehnica University of Timișoara, Romania, where he also\nobtained a doctorate degree. He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. He has developed automation equipment for machine tools, spooling\nmachines, high-power ultrasound processes, and more.",institutionString:"Polytechnic University of Timişoara",institution:{name:"Polytechnic University of Timişoara",country:{name:"Romania"}}},{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",biography:"Dr. Eneko Osaba works at TECNALIA as a senior researcher. He obtained his Ph.D. in Artificial Intelligence in 2015. He has participated in more than twenty-five local and European research projects, and in the publication of more than 130 papers. He has performed several stays at universities in the United Kingdom, Italy, and Malta. Dr. Osaba has served as a program committee member in more than forty international conferences and participated in organizing activities in more than ten international conferences. He is a member of the editorial board of the International Journal of Artificial Intelligence, Data in Brief, and Journal of Advanced Transportation. He is also a guest editor for the Journal of Computational Science, Neurocomputing, Swarm, and Evolutionary Computation and IEEE ITS Magazine.",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"275829",title:"Dr.",name:"Esther",middleName:null,surname:"Villar-Rodriguez",slug:"esther-villar-rodriguez",fullName:"Esther Villar-Rodriguez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/275829/images/system/275829.jpg",biography:"Dr. Esther Villar obtained a Ph.D. in Information and Communication Technologies from the University of Alcalá, Spain, in 2015. She obtained a degree in Computer Science from the University of Deusto, Spain, in 2010, and an MSc in Computer Languages and Systems from the National University of Distance Education, Spain, in 2012. Her areas of interest and knowledge include natural language processing (NLP), detection of impersonation in social networks, semantic web, and machine learning. Dr. Esther Villar made several contributions at conferences and publishing in various journals in those fields. Currently, she is working within the OPTIMA (Optimization Modeling & Analytics) business of TECNALIA’s ICT Division as a data scientist in projects related to the prediction and optimization of management and industrial processes (resource planning, energy efficiency, etc).",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",country:{name:"Spain"}}},{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",biography:"Prof. Dr. Javier Del Ser received his first PhD in Telecommunication Engineering (Cum Laude) from the University of Navarra, Spain, in 2006, and a second PhD in Computational Intelligence (Summa Cum Laude) from the University of Alcala, Spain, in 2013. He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. He is a Senior Member of the IEEE, and a recipient of the Biscay Talent prize for his academic career.",institutionString:"Tecnalia Research & Innovation",institution:null},{id:"278948",title:"Dr.",name:"Carlos Pedro",middleName:null,surname:"Gonçalves",slug:"carlos-pedro-goncalves",fullName:"Carlos Pedro Gonçalves",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRcmyQAC/Profile_Picture_1564224512145",biography:'Carlos Pedro Gonçalves (PhD) is an Associate Professor at Lusophone University of Humanities and Technologies and a researcher on Complexity Sciences, Quantum Technologies, Artificial Intelligence, Strategic Studies, Studies in Intelligence and Security, FinTech and Financial Risk Modeling. He is also a progammer with programming experience in:\n\nA) Quantum Computing using Qiskit Python module and IBM Quantum Experience Platform, with software developed on the simulation of Quantum Artificial Neural Networks and Quantum Cybersecurity;\n\nB) Artificial Intelligence and Machine learning programming in Python;\n\nC) Artificial Intelligence, Multiagent Systems Modeling and System Dynamics Modeling in Netlogo, with models developed in the areas of Chaos Theory, Econophysics, Artificial Intelligence, Classical and Quantum Complex Systems Science, with the Econophysics models having been cited worldwide and incorporated in PhD programs by different Universities.\n\nReceived an Arctic Code Vault Contributor status by GitHub, due to having developed open source software preserved in the \\"Arctic Code Vault\\" for future generations (https://archiveprogram.github.com/arctic-vault/), with the Strategy Analyzer A.I. module for decision making support (based on his PhD thesis, used in his Classes on Decision Making and in Strategic Intelligence Consulting Activities) and QNeural Python Quantum Neural Network simulator also preserved in the \\"Arctic Code Vault\\", for access to these software modules see: https://github.com/cpgoncalves. He is also a peer reviewer with outsanding review status from Elsevier journals, including Physica A, Neurocomputing and Engineering Applications of Artificial Intelligence. Science CV available at: https://www.cienciavitae.pt//pt/8E1C-A8B3-78C5 and ORCID: https://orcid.org/0000-0002-0298-3974',institutionString:"University of Lisbon",institution:{name:"Universidade Lusófona",country:{name:"Portugal"}}},{id:"241400",title:"Prof.",name:"Mohammed",middleName:null,surname:"Bsiss",slug:"mohammed-bsiss",fullName:"Mohammed Bsiss",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241400/images/8062_n.jpg",biography:null,institutionString:null,institution:null},{id:"276128",title:"Dr.",name:"Hira",middleName:null,surname:"Fatima",slug:"hira-fatima",fullName:"Hira Fatima",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/276128/images/14420_n.jpg",biography:"Dr. Hira Fatima\nAssistant Professor\nDepartment of Mathematics\nInstitute of Applied Science\nMangalayatan University, Aligarh\nMobile: no : 8532041179\nhirafatima2014@gmal.com\n\nDr. Hira Fatima has received his Ph.D. degree in pure Mathematics from Aligarh Muslim University, Aligarh India. Currently working as an Assistant Professor in the Department of Mathematics, Institute of Applied Science, Mangalayatan University, Aligarh. She taught so many courses of Mathematics of UG and PG level. Her research Area of Expertise is Functional Analysis & Sequence Spaces. She has been working on Ideal Convergence of double sequence. She has published 17 research papers in National and International Journals including Cogent Mathematics, Filomat, Journal of Intelligent and Fuzzy Systems, Advances in Difference Equations, Journal of Mathematical Analysis, Journal of Mathematical & Computer Science etc. She has also reviewed few research papers for the and international journals. She is a member of Indian Mathematical Society.",institutionString:null,institution:null},{id:"414880",title:"Dr.",name:"Maryam",middleName:null,surname:"Vatankhah",slug:"maryam-vatankhah",fullName:"Maryam Vatankhah",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Borough of Manhattan Community College",country:{name:"United States of America"}}},{id:"414879",title:"Prof.",name:"Mohammad-Reza",middleName:null,surname:"Akbarzadeh-Totonchi",slug:"mohammad-reza-akbarzadeh-totonchi",fullName:"Mohammad-Reza Akbarzadeh-Totonchi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Ferdowsi University of Mashhad",country:{name:"Iran"}}},{id:"414878",title:"Prof.",name:"Reza",middleName:null,surname:"Fazel-Rezai",slug:"reza-fazel-rezai",fullName:"Reza Fazel-Rezai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"American Public University System",country:{name:"United States of America"}}},{id:"302698",title:"Dr.",name:"Yao",middleName:null,surname:"Shan",slug:"yao-shan",fullName:"Yao Shan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Dalian University of Technology",country:{name:"China"}}},{id:"125911",title:"Prof.",name:"Jia-Ching",middleName:null,surname:"Wang",slug:"jia-ching-wang",fullName:"Jia-Ching Wang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"National Central University",country:{name:"Taiwan"}}},{id:"357085",title:"Mr.",name:"P. 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Shukla",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Indian Institute of Technology Kanpur",country:{name:"India"}}},{id:"356823",title:"MSc.",name:"Seonghee",middleName:null,surname:"Min",slug:"seonghee-min",fullName:"Seonghee Min",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Daegu University",country:{name:"Korea, South"}}},{id:"353307",title:"Prof.",name:"Yoosoo",middleName:null,surname:"Oh",slug:"yoosoo-oh",fullName:"Yoosoo Oh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:"Yoosoo Oh received his Bachelor's degree in the Department of Electronics and Engineering from Kyungpook National University in 2002. He obtained his Master’s degree in the Department of Information and Communications from Gwangju Institute of Science and Technology (GIST) in 2003. In 2010, he received his Ph.D. degree in the School of Information and Mechatronics from GIST. In the meantime, he was an executed team leader at Culture Technology Institute, GIST, 2010-2012. In 2011, he worked at Lancaster University, the UK as a visiting scholar. In September 2012, he joined Daegu University, where he is currently an associate professor in the School of ICT Conver, Daegu University. Also, he served as the Board of Directors of KSIIS since 2019, and HCI Korea since 2016. From 2017~2019, he worked as a center director of the Mixed Reality Convergence Research Center at Daegu University. From 2015-2017, He worked as a director in the Enterprise Supporting Office of LINC Project Group, Daegu University. His research interests include Activity Fusion & Reasoning, Machine Learning, Context-aware Middleware, Human-Computer Interaction, etc.",institutionString:null,institution:{name:"Daegu Gyeongbuk Institute of Science and Technology",country:{name:"Korea, South"}}},{id:"262719",title:"Dr.",name:"Esma",middleName:null,surname:"Ergüner Özkoç",slug:"esma-erguner-ozkoc",fullName:"Esma Ergüner Özkoç",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Başkent University",country:{name:"Turkey"}}},{id:"346530",title:"Dr.",name:"Ibrahim",middleName:null,surname:"Kaya",slug:"ibrahim-kaya",fullName:"Ibrahim Kaya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Izmir Kâtip Çelebi University",country:{name:"Turkey"}}},{id:"419199",title:"Dr.",name:"Qun",middleName:null,surname:"Yang",slug:"qun-yang",fullName:"Qun Yang",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Auckland",country:{name:"New Zealand"}}}]}},subseries:{item:{id:"13",type:"subseries",title:"Plant Physiology",keywords:"Plant Nutrition, Plant Hormone, Photosynthesis, Respiration, Plant Stress, Multi-omics, High-throughput Technology, Genome Editing",scope:"Plant Physiology explores fundamental processes in plants, and it includes subtopics such as plant nutrition, plant hormone, photosynthesis, respiration, and plant stress. 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Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"313856",title:"Dr.",name:"Christophe",middleName:"F.E.",surname:"Hano",slug:"christophe-hano",fullName:"Christophe Hano",profilePictureURL:"https://mts.intechopen.com/storage/users/313856/images/system/313856.png",institutionString:"University of Orléans",institution:{name:"University of Orléans",institutionURL:null,country:{name:"France"}}},{id:"33993",title:"Dr.",name:"Jose Carlos",middleName:null,surname:"Jimenez-Lopez",slug:"jose-carlos-jimenez-lopez",fullName:"Jose Carlos Jimenez-Lopez",profilePictureURL:"https://mts.intechopen.com/storage/users/33993/images/system/33993.jpg",institutionString:"Spanish National Research Council",institution:{name:"Spanish National Research Council",institutionURL:null,country:{name:"Spain"}}},{id:"191770",title:"Dr.",name:"Mohamed A.",middleName:null,surname:"El-Esawi",slug:"mohamed-a.-el-esawi",fullName:"Mohamed A. 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Dr. Şentürk currently works as an professor of Biochemistry in the Department of Basic Pharmacy Sciences, Faculty of Pharmacy, Ağri Ibrahim Cecen University, Turkey. \nDr. Şentürk published over 120 scientific papers, reviews, and book chapters and presented several conferences to scientists. \nHis research interests span enzyme inhibitor or activator, protein expression, purification and characterization, drug design and synthesis, toxicology, and pharmacology. \nHis research work has focused on neurodegenerative diseases and cancer treatment. 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He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. 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She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,series:{id:"11",title:"Biochemistry"}}},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"profile.detail",path:"/profiles/188026",hash:"",query:{},params:{id:"188026"},fullPath:"/profiles/188026",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()