Summary of predictors of poor outcome at the long-term follow-up.
\\n\\n
Dr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\\n\\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\\n\\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\\n\\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\\n\\nThank you all for being part of the journey. 5,000 times thank you!
\\n\\nNow with 5,000 titles available Open Access, which one will you read next?
\\n\\nRead, share and download for free: https://www.intechopen.com/books
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Preparation of Space Experiments edited by international leading expert Dr. Vladimir Pletser, Director of Space Training Operations at Blue Abyss is the 5,000th Open Access book published by IntechOpen and our milestone publication!
\n\n"This book presents some of the current trends in space microgravity research. The eleven chapters introduce various facets of space research in physical sciences, human physiology and technology developed using the microgravity environment not only to improve our fundamental understanding in these domains but also to adapt this new knowledge for application on earth." says the editor. Listen what else Dr. Pletser has to say...
\n\n\n\nDr. Pletser’s experience includes 30 years of working with the European Space Agency as a Senior Physicist/Engineer and coordinating their parabolic flight campaigns, and he is the Guinness World Record holder for the most number of aircraft flown (12) in parabolas, personally logging more than 7,300 parabolas.
\n\nSeeing the 5,000th book published makes us at the same time proud, happy, humble, and grateful. This is a great opportunity to stop and celebrate what we have done so far, but is also an opportunity to engage even more, grow, and succeed. It wouldn't be possible to get here without the synergy of team members’ hard work and authors and editors who devote time and their expertise into Open Access book publishing with us.
\n\nOver these years, we have gone from pioneering the scientific Open Access book publishing field to being the world’s largest Open Access book publisher. Nonetheless, our vision has remained the same: to meet the challenges of making relevant knowledge available to the worldwide community under the Open Access model.
\n\nWe are excited about the present, and we look forward to sharing many more successes in the future.
\n\nThank you all for being part of the journey. 5,000 times thank you!
\n\nNow with 5,000 titles available Open Access, which one will you read next?
\n\nRead, share and download for free: https://www.intechopen.com/books
\n\n\n\n
\n'}],latestNews:[{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"},{slug:"oiv-awards-recognizes-intechopen-s-editors-20201127",title:"OIV Awards Recognizes IntechOpen's Editors"},{slug:"intechopen-joins-crossref-s-initiative-for-open-abstracts-i4oa-to-boost-the-discovery-of-research-20201005",title:"IntechOpen joins Crossref's Initiative for Open Abstracts (I4OA) to Boost the Discovery of Research"},{slug:"intechopen-hits-milestone-5-000-open-access-books-published-20200908",title:"IntechOpen hits milestone: 5,000 Open Access books published!"},{slug:"intechopen-books-hosted-on-the-mathworks-book-program-20200819",title:"IntechOpen Books Hosted on the MathWorks Book Program"}]},book:{item:{type:"book",id:"640",leadTitle:null,fullTitle:"Modern Arthroscopy",title:"Modern Arthroscopy",subtitle:null,reviewType:"peer-reviewed",abstract:"Modern Arthroscopy will assist practitioners to stay current in the rapidly changing field of arthroscopic surgery. 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Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating neurological condition and is associated with high morbidity and mortality. Poor-grade aSAH accounts for approximately 30% of all aSAH, and it is a severe subtype of aSAH. These patients more often present with acute hydrocephalus, severe intraventricular hemorrhage, microcirculatory disturbances, and even multi-organ failure after ictus [1, 2] . Traditionally, these patients are managed conservatively, and only those who show clinical improvement were selected for aggressive treatment [1, 3, 4]. However, aneurysm rebleeding occurs in patients with poor-grade aSAH, and about 50% of rebleeding is at the early stage after the hemorrhage [5]. Nowadays endovascular coiling, surgical clipping, and intensive neurocritical care have improved outcomes in patients with poor-grade aSAH [6, 7, 8, 9, 10, 11]. However, more than 60% of patients have unfavorable outcomes with severe disability [12]. The treatment decision-making is still challenging. There are limited data on high-level clinical trials focusing on the treatment of poor-grade aSAH. Therefore, we review the current therapeutical management and prognosis of poor-grade aSAH.
\nSeveral grading systems, including Glasgow coma score (GCS), WFNS grade (World Federation of Neurological Societies), Hunt & Hess scale, or modified Hunt & Hess scale, have been used for initial clinical assessment of aSAH. Patients with poor-grade aSAH often present with stupor or coma because of the primary brain injury. WFNS grade has better inter- and intraobserver reliability than Hunt & Hess scale and makes it more appropriate [13]. Poor-grade aSAH is defined as WFNS grade IV or V (a GCS score of 7–12 for grade IV and 3–6 for grade V) [14]. It is important to detect ruptured aneurysms in the setting of poor-grade aSAH. These patients are often unstable and require sedation or anesthesia during examination.
\nTraditionally, digital subtraction angiography (DSA) is the gold standard technique for detecting ruptured aneurysms [15, 16, 17, 18, 19]. CT angiography (CTA) is less invasive and less time-consuming in providing information on ruptured intracranial aneurysms as a primary examination tool for aSAH. Current studies have reported the sensitivity and specificity of CTA for detecting intracranial aneurysms [20]. Matsumoto et al. [21] reported that 27 patients underwent successful surgical clipping based on CTA alone. Our previous study reported that more than a third of patients underwent successful surgical treatment on the basis of CTA alone [22]. All ruptured aneurysms were detected and clipped. Complications and clinical outcomes did not significantly differ between CTA alone and DSA group. Therefore, CTA can provide fast and accurate diagnostic and anatomic information on ruptured aneurysms and it can be safely and effectively used in most patients with poor-grade aSAH requiring surgical treatment. Patients with smaller ruptured aneurysms or multiple aneurysms may be considered for additional DSA examination.
\nRebleeding more often occurs in patients with poor-grade aSAH [23, 24, 25, 26, 27]. Van Donkelaar et al. [28] reported that 41 (11.0%) of 374 patients experienced rebleeding. Of the 297 patients included in our previous study, 30 (10.1%) patients experienced rebleeding; 14 (46.7%) cases occurred within 24 h after ictus, 11 (36.7%) occurred between 1 and 7 days, and 5 (16.6%) occurred after 7 days [5]. High blood pressure, poor-grade clinical condition, modified Fisher grade, posterior circulation aneurysms, larger aneurysms (>10 mm), intracerebral or intraventricular hemorrhage are reported to be important predictors of rebleeding after aSAH [24, 28, 29, 30]. Van Donkelaar et al. [28] reported that a higher modified Fisher grade was a strong risk factor associated with a rebleeding probably because the amount of blood was a marker of stability of the ruptured aneurysm wall.
\nMany neurosurgeons use preoperative ventricular drainage in all patients with poor-grade aSAH to maintain adequate cerebral perfusion [15, 24, 31, 32, 33]; however, there is no guideline for the drainage after poor-grade aSAH. Laidlaw and Siu reported that 2 of 133 patients treated with surgery underwent ventricular drainage because of the concern of rebleeding [34]. On the other hand, several studies found no increased risk of rebleeding after the drainage [35, 36]. Our previous study showed that a lower Fisher grade, ruptured anterior cerebral artery aneurysms, and preoperative external ventricular drainage were independently associated with rebleeding after poor-grade aSAH [5]. Therefore, these patients may have increased risk of rebleeding after ventricle drainage without aneurysm repair, and early aneurysm treatment may be considered for patients who required emergency ventricle drainage.
\nPoor-grade aSAH should be treated with a multidisciplinary team that consists of neurologists, neurosurgeons, interventional neuroradiologists, and anesthetists. Emergency treatment should include aggressive resuscitation to keep the basic life support. Central venous catheters are first inserted for fluid and medicine administration and hemodynamic monitoring. Systolic blood pressure should be maintained below 160 mmHg to prevent the rebleeding. Oral or nasotracheal intubation should be performed if the patients require respiratory support.
\nThere is no consensus regarding the optimal timing of treatment for poor-grade aSAH. Traditionally, these patients have been managed medically and only undergo the treatment of the ruptured aneurysm when clinically stabilized and improved. In the past decades, several studies have shown that early surgery (within 72 h of ictus) improved the outcome in selected patients with poor-grade aneurysms [15, 16, 17, 33, 37, 38, 39]. At more than 6 months of follow-up, 46% of patients had a good outcome after early surgical clipping [40]. Zentner et al. [41] reported that early surgery resulted in a good outcome of 22% of patients with the worst grade. A study of 103 patients with grade V showed a good outcome in 26% of patients at follow-up [42]. Despite the rates of morbidity and death remaining high in patients with WFNS grade V, these findings suggest that early aneurysm repair is feasible and safe for poor-grade aSAH. Early treatment for ruptured aneurysm may help reduce the risk of rebleeding and manage cerebral vasospasm and delayed ischemia. Patients with younger age, WFNS IV after emergency resuscitation, and middle cerebral artery aneurysms are more likely to have a favorable outcome after early surgery [43].
\nAneurysm treatment as early as possible is recommended to prevent rebleeding after initial aSAH [44, 45]. Ultra-early treatment (within 24 h) reduces the risk of rebleeding and improves outcomes in most patients with good-grade aSAH [46, 47, 48]. However, there is no evidence to support ultra-early treatment of poor-grade aSAH because these patients experience more severe brain swelling than good-grade patients [42, 49]. With development in microsurgical techniques, there has been growing interest in ultra-early treatment of aSAH. A current series of 78 patients with poor-grade treated with surgical treatment showed 44 patients (56%) had a good outcome, including 26% of patients presenting with WFNS grade V, and surgery was performed within 24 h after admission [33]. In a multicenter and contemporary cohort of poor-grade aSAH, 47 (40%) of 118 patients underwent ultra-early surgery, 16 (34%) patients in ultra-early surgery group and 42 (59%) patients in delayed group had a good outcome [50]. Laidlaw et al. [17, 34]reported 40% of patients were independent after 3 months and 45% died. With coiling, there are few technical limitations to ultra-early treatment of aSAH as the limitations related to inflammation and brain swelling do not affect the technical aspects of the procedure [51].
\nA current meta-analysis and systemic review of poor-grade aSAH evaluated outcomes by timing of treatment modality and found that patients receiving ultra-early treatment (within 48 h of aSAH) had the highest rates of good neurological outcome (61% compared to 40% for early and 47% for delayed) [12]. Park et al. [47] reported that ultra-early surgery did not significantly decrease the incidence of rebleeding of poor-grade aSAH and also that it was not associated with outcomes [18, 47, 48]. Ultra-early aneurysm treatment of poor-grade aSAH still remains controversial.
\nSurgical treatment includes external ventricular drainage for hydrocephalus or intraventricular hemorrhage, surgical clipping of ruptured aneurysms, and decompressive craniectomy. Surgical selections are based on aneurysm morphology, patient’s neurological condition, and treatment relative risk following multidisciplinary consultation. Patients with associated large intracerebral hemorrhage (more than 30 ml) are more often considered for surgical clipping. After surgery, patients are transferred to the intensive care unit, and they are treated with standard management for vasospasm. Illustrative case receiving surgical clipping is shown in Figure 1.
\nA 45-year-old male presented with unconsciousness for 2 h and had a Glasgow coma score of 6 and World Federation of Neurosurgical Surgeon grade of V at admission. He was treated with emergency surgical clipping of ruptured aneurysm and hematoma evacuation. He recovered well and had a modified Rankin scale of 1 at 12 months of follow-up. (A) Emergency CT scan shows a large frontotemporal parietal lobe hematoma and midline shift to left side. (B) CT angiography shows a right middle cerebral artery bifurcation aneurysm. (C) CT shows a slight edema of surgical field after 10 days of surgery.
The international subarachnoid aneurysm trial (ISAT) demonstrated that for aSAH amenable to both treatments, patients treated with endovascular coiling had better outcomes than patients treated with surgical clipping [52]. Although endovascular treatment has been used as an available alternative to surgery for aSAH, surgical treatment is still an important treatment modality for poor-grade aSAH. In the contemporary multicenter cohorts of poor-grade aSAH, patients receiving clipping more often had a lower GCS score, a WFNS grade of V, a higher Fisher grade and modified Fisher grade, and a ruptured anterior circulation aneurysm than those receiving coiling [53]. Patients with WFNS grade V after emergency resuscitation, a better Fisher grade, brain herniation, the presence of ICH, or the absence of IVH more often underwent early surgical clipping [43]. Patients with brain herniation more commonly are treated with surgery. There are no significant differences in rebleeding, cerebral infarction, symptomatic vasospasm, seizure, pneumonia between coiling and clipping groups. There is also no significant difference in outcomes at 6 and 12 months between the two treatments [53].
\nDecompressive craniectomy has been reported in the treatment for severe traumatic brain injury, massive ischemic stroke, and aSAH [54, 55, 56, 57, 58, 59, 60]. This procedure can reduce increased intracranial pressure and improve cerebral perfusion and outcomes in selected patients with ruptured aneurysms with associated intracerebral hemorrhage [61]. However, there are no studies focusing on the safety and efficacy of decompressive craniectomy for poor-grade aSAH compared with conventional craniotomy. Our previous study has shown that primary decompressive craniectomy does not increase postoperative complications and can be performed safely in poor-grade sSAH. More than one-half of patients benefit from primary decompressive craniectomy.
\nSince the ISAT study, endovascular treatment is more commonly used than clipping for ruptured aneurysm. Aneurysms can be coiled though the minimally invasive endovascular approach to reduce the rate of rebleeding and avoid brain swelling and high intracranial pressure. Endovascular treatment is performed in continuity with the initial angiography and requires less treatment time. The current results at the 3- and 6-year follow-up in the ruptured aneurysm treatment study showed that there was no significant difference in outcome between the two treatments for ruptured aneurysms [62, 63]. A current systematic review of surgical and endovascular treatment of poor-grade aSAH has also shown that the proportion of patients with endovascular coiling increased from 10.0 to 62.0% between 1990 and 2000 and 2010 and 2014 [12]. Therefore, endovascular coiling is a feasible and reasonable option for poor-grade aSAH. Illustrative case receiving coiling is shown in Figure 2.
\nA 53-year-old male presented with unconsciousness for 1 h and had a Glasgow coma score of 5 and World Federation of Neurosurgical Surgeon grade of V at admission. He was treated with emergency coiling of ruptured aneurysm and external ventricle drainage. He had a modified Rankin scale of 3 at 12 months of follow-up. (A) Emergency CT scan shows severe subarachnoid hemorrhage and frontal lobe hematoma. (B) Preoperative angiography shows a very small anterior communicating artery aneurysm. (C) Immediate angiography shows complete occlusion of aneurysms using coils.
Mocco et al. [31] reported that 35 (35.7%) of 98 patients received coiling, and there was also similar outcome between coiling and clipping for poor-grade aSAH. In our prospective and multicenter registry of 262 patients with poor-grade ruptured aneurysm, 133 (50.8%) patients received endovascular coiling within 21 days after poor-grade aSAH [53]. An unadjusted analysis showed that the rate of outcome (mRS 0–2 or mRS 0–3) at discharge at 6 and 12 months in the coiled patients was higher than that in the clipped patients probably because of selection bias. In our exploratory analysis, there was no significant difference in clinical outcomes between the two groups. Patients receiving coiling had a higher risk of radiological hydrocephalus than clipped patients, and there was a trend toward clinical hydrocephalus after coiling. However, Zaidi et al. [64] found that there was no difference in hydrocephalus among patients treated by coiling or clipping.
\nWith advances of endovascular technology, stent-assisted coiling has been used in the treatment of ruptured aneurysms. There is a main concern about the safety of stent-assisted coiling for poor-grade ruptured aneurysms. A review reported clinical outcomes in the stent-assisted coiling were worse than those in the coiling alone of acutely ruptured aneurysms [65]. Several studies showed that hemorrhagic complications often occurred in patients with acutely ruptured aneurysms after stent-assisted coiling and external ventricular drainage probably because of dual-antiplatelet therapy [66, 67, 68]. Using a multicenter poor-grade aneurysm study, we compared perioperative complications, and clinical outcomes between the stent-assisted coiling and the coiling-alone groups [69]. Twenty-three (17.6%) patients were treated with stent-assisted coiling compared with 108 (82.4%) patients treated with coiling alone. There were no statistically significant differences in intraprocedural rupture, procedure-related ischemic complication, ventricle drainage-related hemorrhagic complication, and symptomatic vasospasm between the stent-assisted coiling group and the coiling-alone group. However, there was a trend toward rebleeding after stent-assisted coiling. The hemorrhagic complication should be considered before the treatment decision-making. Therefore, treatment of wide-necked ruptured aneurysms remains challenging and we still require improvement of endovascular treatment of wide-neck ruptured aneurysms. A clinical trial focused on poor-grade ruptured aneurysms may be necessary to assess the efficacy of the treatment.
\nThe clinical outcomes of patients with aneurysm rebleeding remain very poor probably because of a severe secondary brain injury caused by a large cerebral hematoma or severe intraventricular hemorrhage. The rebleeding is independently associated with poor outcome (odds ratio [OR] 36.37, p < 0.001) and associated with mortality (OR 25.03, p < 0.001) at 12 months [5]. Tanno et al. [70] reported that 152 (84%) of 181 patients presented with semicoma to coma after rebleeding. Of the 30 patients with rebleeding in our previous study, 22 (73.3%) patients died at discharge. At 12 months, 2 (6.7%) patients had a modified Rankin Score (mRS) of 1, 1 (3.3%) had a mRS of 4, and 26 (86.7%) died [5]. A higher modified Fisher grade before rebleeding, larger aneurysms, and a lower GCS score after rebleeding were independently associated with increased mortality. A lower WFNS grade treated with aggressive treatment is more likely to have a good outcome [71].
\nAggressive treatment and successful aneurysm repair can reduce the rebleeding and improve clinical outcomes in selected patients. In a current review of poor-grade aSAH, the rate of good outcome increased from 37.0 to 44.0% over the years. Good outcome was 38% (95% CI = 33–43%) in the endovascular group and 39% (95% CI = 34–44%) in the surgical group at the over 6 months of follow-up [12]. In our multicenter poor-grade aneurysm study [53], 52 (19.8%) patients had a mRS score of 0 or 1, 98 (29.8%) had a mRS score of 0–2, 112 (32.4%) had a mRS score of 0–3, and 51 (19.5%) had died at discharge. Ninety-five (36.3%) patients had a mRS score of 0 or 1, 115 (43.9%) had a mRS of 0–2, 126 (48.1%) had a mRS of 0–3, and 103 (39.3%) had died at 12 months. The outcome is improved after endovascular coiling or clipping over time of the follow-up [53]. In a prospective database of poor-grade aSAH patients, 40% of the 98 patients had a favorable outcome at 12 months [31]. In the 136 patients receiving endovascular coiling, 59 (43.3%) patients had a mRS of 0 or 1, and 64 (47.0%) had a poor outcome (mRS4-6) [72].
\nAbout one-half of patients achieve a good outcome after the treatment, therefore predicting outcome after poor-grade aSAH is essential to support early treatment [73]. A few prognostic prediction models have been reported [3, 31, 74]. However, these studies are from a single center or have a limited sample size. Older age, lower GCS score, absence of pupil reactivity, higher modified Fisher grade, and conservative treatment are associated with poor outcome in most studies [3, 31, 74, 75]. These predictors of poor outcome are summarized in Table 1. We developed an integer-based outcome risk score (WAP) to predict the long-term outcomes [76]. The WAP score consists of three variables: WFNS grade, Age (three categories), and Pupillary reactivity. The sum of the weighted scores was used to assess the overall score and was ranged from 0 to 4. The predicted risk of poor outcome ranged from 25.5% for a WAP score of 0 to 96.2% for a score of 4. The risk score is easily measured and may complement treatment decision-making [76].
\nAuthors | \nStudy design | \nMean time of follow-up | \nTreatments | \nPredictors of poor outcome | \n
---|---|---|---|---|
Le Roux et al. | \nRetrospective | \n6 months | \nClipping | \nHunt & Hess Grade V, blood glucose, fibrin degradation products, severity of ventricular hemorrhage, low density on CT, no clinical improvement | \n
Huang et al. | \nRetrospective | \n6 months | \nClipping | \nHunt-Hess grade, aneurysm size, rehemorrhage before surgery, acute hydrocephalus | \n
Mocco et al. | \nProspective | \n12 months | \nClipping and coiling | \nOlder than 65 years, hyperglycernia preoperative Hunt & Hess Grade V, and aneurysm size of at least 13 mm | \n
Zhao et al. | \nProspective | \n12 months | \nClipping | \nOlder age, WFNS grade V, brain herniation, intraventricular hemorrhage, non-middle cerebral artery aneurysms | \n
Zhao et al. | \nProspective | \n12 months | \nCoiling | \nOlder age, WFNS grade of V, higher modified Fisher grade, wider neck aneurysm | \n
Zheng et al. | \nProspective | \n12 months | \nClipping, coiling, and conservative treatment | \nOlder age, lower Glasgow coma scale score (GCS), the absence of pupillary reactivity, higher modified Fisher grade, and conservative treatment | \n
Summary of predictors of poor outcome at the long-term follow-up.
Poor-grade aSAH is a severe subtype of subarachnoid hemorrhage caused by ruptured aneurysms. Timing of treatment for the aSAH has shifted from delayed to early surgery, and there will be a trend toward ultra-early treatment for poor-grade aSAH. However, there is no consensus regarding the optimal timing of treatment for poor-grade aSAH. Although endovascular treatment has been used as an available alternative to surgical clipping for aSAH, surgical treatment is still an important treatment modality for poor-grade aSAH. Despite advancements in aneurysm treatment, the morbidity and mortality of poor-grade aSAH remain high. Many retrospective studies have reported the predictors of outcomes, but there is not appropriate prediction model for poor-grade aSAH. The treatment decision-making is still challenging. Further prospective cohort study or clinical trials focused on poor-grade aSAH are required to help guide treatment decisions for this devastating condition.
\nThis work was supported by Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support (20171914), Shanghai Municipal Commission of Health and Family Planning (201740080), Shanghai Science and Technology Project (18411962700), and the Clinical Research Plan of SHDC (16CR3031A, 16CR2045B), the Shanghai Jiaotong University Medical Engineering and translational Cross-cutting Research Foundation (YG2017MS45, ZH2018ZDA07), Shanghai Jiaotong University School of Medicine Research Project (DLY201821).
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