Secondary metabolites obtained for cellular cultures from medicinal plant tissues
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"9525",leadTitle:null,fullTitle:"Insights Into Drug Resistance in Staphylococcus aureus",title:"Insights Into Drug Resistance in Staphylococcus aureus",subtitle:null,reviewType:"peer-reviewed",abstract:"Staphylococcus aureus is a coccus, gram-positive, non-spore forming, and non-motile bacterium. Its commensal and opportunistic capabilities make it able to colonize different sites of animals and humans. Resistance to antibiotics has resulted in development of new strains and new types within strains. Types of methicillin-resistant S. aureus (MRSA) include hospital-acquired MRSA (HA-MRSA), community-acquired MRSA (CA-MRSA), and livestock-acquired MRSA (LA-MRSA). There are also new strains like vancomycin-resistant S. aureus (VRSA) and vancomycin-intermediate S. aureus (VISA). Expansion in resistance is expected to give rise to newer strains resistant to antibiotics such as macrolide (erm gene), tetracycline (tet genes), mupirocin (mupR), and fusidic acid (fusD). Alternative approaches like nanoparticles, bacteriophages, phytochemicals, and more are required to tackle this pathogen. This book contains information on epidemiology, resistance mechanisms, and alternative ways to curtail S. aureus infection, as well as future research opportunities.",isbn:"978-1-83962-743-9",printIsbn:"978-1-83962-742-2",pdfIsbn:"978-1-83962-744-6",doi:"10.5772/intechopen.87320",price:119,priceEur:129,priceUsd:155,slug:"insights-into-drug-resistance-in-staphylococcus-aureus",numberOfPages:252,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"98bb6c1ddb067da67185c272f81c0a27",bookSignature:"Amjad Aqib",publishedDate:"December 8th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/9525.jpg",numberOfDownloads:3070,numberOfWosCitations:0,numberOfCrossrefCitations:3,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:7,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:10,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 8th 2020",dateEndSecondStepPublish:"October 6th 2020",dateEndThirdStepPublish:"December 5th 2020",dateEndFourthStepPublish:"February 23rd 2021",dateEndFifthStepPublish:"April 24th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Agriculture Faisalabad",institutionURL:null,country:{name:"Pakistan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1046",title:"Infectious Diseases",slug:"infectious-diseases"}],chapters:[{id:"79046",title:"Antibiotic Resistant Staphylococcus aureus",doi:"10.5772/intechopen.100057",slug:"antibiotic-resistant-em-staphylococcus-aureus-em-",totalDownloads:159,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus is an adaptable pathogen and leads to rapid development of antibiotic resistance. The major targets for antibiotics are (i) the cell wall, (ii) the ribosome and (iii) nucleic acids. Resistance can either develop intrinsically or extrinsically via horizontal gene transfer, drug site modification, and efflux pumps etc. This review focuses on development of resistance to currently used antibiotics in Staphylococcal infection, novel therapeutic approaches resistance pattern of antibiotics and also the future prospectus for new antibiotics usage.",signatures:"Arun Kumar Parthasarathy and Roma A. Chougale",downloadPdfUrl:"/chapter/pdf-download/79046",previewPdfUrl:"/chapter/pdf-preview/79046",authors:[{id:"342035",title:"Assistant Prof.",name:"Arun",surname:"Kumar",slug:"arun-kumar",fullName:"Arun Kumar"},{id:"446709",title:"Dr.",name:"Roma",surname:"A. Chougale",slug:"roma-a.-chougale",fullName:"Roma A. Chougale"}],corrections:null},{id:"78841",title:"Genetic Diversity in Staphylococcus aureus and Its Relation to Biofilm Production",doi:"10.5772/intechopen.99967",slug:"genetic-diversity-in-em-staphylococcus-aureus-em-and-its-relation-to-biofilm-production",totalDownloads:185,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus (S. aureus) has been a substantial economic problem due to its antibiotic resistance, persistence inside host and recurrence of disease. It escapes from immunity because of its intra-cellular growth. Moreover, it forms biofilm on both living and in-animate surfaces that leads to recurrent infections and growth in food industry, respectively. Further, S. aureus undergoes the vertical and horizontal evolution that has genetically diversified the bacterial population. All the factors such as point mutations, plasmids, phages etc. have played their roles in diversifying this bacterium. Many bacterial physiological characteristics have been affected by genetic diversity. Biofilm forming ability is also considered as a variable characteristic of S. aureus that can help the bacteria to survive in different environments with different levels of biofilm production. In adapting the environment, S. aureus also forms different types of biofilm for its better survival. How genetic diversity is playing its role in this division of S. aureus is yet to be revealed. This chapter focuses on the factors related to genetic diversity and biofilm formation of S. aureus.",signatures:"Furqan Awan, Muhammad Muddassir Ali, Muhammad Hassan Mushtaq and Muhammad Ijaz",downloadPdfUrl:"/chapter/pdf-download/78841",previewPdfUrl:"/chapter/pdf-preview/78841",authors:[{id:"344919",title:"Dr.",name:"Furqan",surname:"Awan",slug:"furqan-awan",fullName:"Furqan Awan"},{id:"349343",title:"Dr.",name:"Muhammad Muddassir",surname:"Ali",slug:"muhammad-muddassir-ali",fullName:"Muhammad Muddassir Ali"},{id:"349494",title:"Prof.",name:"Muhammad Hassan",surname:"Mushtaq",slug:"muhammad-hassan-mushtaq",fullName:"Muhammad Hassan Mushtaq"},{id:"349495",title:"Dr.",name:"Muhammad",surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz"}],corrections:null},{id:"77315",title:"Staphylococcus aureus and Virulence-Related Small RNA",doi:"10.5772/intechopen.98520",slug:"-em-staphylococcus-aureus-em-and-virulence-related-small-rna",totalDownloads:183,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus causes a wide range of diseases, including both community-associated and hospital-acquired infections such as abscesses, wound infections, osteomyelitis, endocarditis and septicemia. Regulation of the expression of various virulence factors is initiated through complex coordination between two-component systems, transcriptional regulatory proteins and regulatory small RNAs (sRNAs). S.aureus uses many sRNA and RNA–RNA interactions mediated the regulation of the expression of genes post-transcriptionally, but it uses few sigma factors to initiate the transcription function. sRNA transcripts are encoded within intergenic regions or in antisense orientation to mRNA transcripts, and sRNA regulation plays a central role in the response to stress stimuli encountered by pathogens during infection. One of the most intriguing examples of sRNA-mediated post-transcriptional regulation is RNAIII from S.aureus, which interacts with and regulates various RNA targets involved in virulence. Several genes known to be regulated by RNAIII have been demonstrated to be regulated by the sarA locus, independent of its effect on the expression of RNAIII. We discuss the potential role of small RNA (sRNA) in the pathogenesis and virulence factors production of Staphylococcus aureus.",signatures:"Rudra Mishra Awdhesh Kumar Mishra, Bhama Mishra Awdhesh Kumar Mishra, Nalini Easwaran and Kodiveri Muthukaliannan Gothandam",downloadPdfUrl:"/chapter/pdf-download/77315",previewPdfUrl:"/chapter/pdf-preview/77315",authors:[{id:"338641",title:"Ph.D. Student",name:"Rudra",surname:"Mishra",slug:"rudra-mishra",fullName:"Rudra Mishra"},{id:"345499",title:"M.Sc.",name:"Bhama",surname:"Mishra",slug:"bhama-mishra",fullName:"Bhama Mishra"},{id:"346854",title:"Prof.",name:"Kodiveri Muthukaliannan",surname:"Gothandam",slug:"kodiveri-muthukaliannan-gothandam",fullName:"Kodiveri Muthukaliannan Gothandam"},{id:"346892",title:"Dr.",name:"Nalini",surname:"Easwaran",slug:"nalini-easwaran",fullName:"Nalini Easwaran"}],corrections:null},{id:"78589",title:"Mechanistic Insights of Drug Resistance in Staphylococcus aureus with Special Reference to Newer Antibiotics",doi:"10.5772/intechopen.100045",slug:"mechanistic-insights-of-drug-resistance-in-em-staphylococcus-aureus-em-with-special-reference-to-new",totalDownloads:195,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus is the most ubiquitous microorganism in both environment as well as animals and exists as commensal and pathogenic bacterium. In past few years it has been emerged as a superbug causing serious burden on healthcare system. This bacterium has been found to be the most resistant one toward most of the antibiotics due to its rapid structural and genetic modifications. This chapter will shed light on various types of molecular mechanisms responsible for resistance of Staphylococcus aureus showcasing how it has been emerged as a superbug. Moreover, the recent approaches which include exploring of different drug targets keeping in view the structural and functional behavior of the Staphylococcus aureus has also been discussed.",signatures:"Atamjit Singh, Kirandeep Kaur, Pallvi Mohana, Avneet Kaur, Komalpreet Kaur, Shilpa Heer, Saroj Arora, Neena Bedi and Preet Mohinder Singh Bedi",downloadPdfUrl:"/chapter/pdf-download/78589",previewPdfUrl:"/chapter/pdf-preview/78589",authors:[{id:"238958",title:"Mr.",name:"Atamjit",surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh"},{id:"240090",title:"Ms.",name:"Kirandeep",surname:"Kaur",slug:"kirandeep-kaur",fullName:"Kirandeep Kaur"},{id:"344857",title:"Ms.",name:"Shilpa",surname:"Heer",slug:"shilpa-heer",fullName:"Shilpa Heer"},{id:"351125",title:"Ms.",name:"Komalpreet",surname:"Kaur",slug:"komalpreet-kaur",fullName:"Komalpreet Kaur"},{id:"351131",title:"Mr.",name:"Preet Mohinder Singh",surname:"Bedi",slug:"preet-mohinder-singh-bedi",fullName:"Preet Mohinder Singh Bedi"},{id:"351134",title:"Dr.",name:"Neena",surname:"Bedi",slug:"neena-bedi",fullName:"Neena Bedi"},{id:"421451",title:"Prof.",name:"Saroj",surname:"Arora",slug:"saroj-arora",fullName:"Saroj Arora"},{id:"421452",title:"Ms.",name:"Pallvi",surname:"Mohana",slug:"pallvi-mohana",fullName:"Pallvi Mohana"},{id:"421453",title:"Ms.",name:"Avneet",surname:"Kaur",slug:"avneet-kaur",fullName:"Avneet Kaur"}],corrections:null},{id:"75953",title:"Antimicrobial Resistance in Staphylococcus aureus",doi:"10.5772/intechopen.96888",slug:"antimicrobial-resistance-in-em-staphylococcus-aureus-em-",totalDownloads:403,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Staphylococcus aureus is a Gram-Positive bacteria that are responsible to cause skin infections and also shows toxic shock syndrome. Several antibiotics were given against the S. aureus infections but eventually, the prevalence of multidrug resistance of Staphylococcus aureus started emerging. Since then Methicillin-resistant Staphylococcus aureus strains (MRSA)were very common which causes nosocomial infections. Microorganisms for the need of the survival undergoes mutational changes either in their chromosomal DNA/RNA which confers the resistance. One of the famous examples is the resistance against methicillin in Staphylococcus aureus. The evolution of S. aureus is successful in developing multiple resistant strains. Plasmids are capable of carrying the resistant genes and also several toxic genes. In a recent study, it has been observed that drug resistance genes are located in the R plasmids and they are also responsible in conferring multi drug resistance and induce less utilization of multiple antimicrobial therapy. MRSA was not only resistant to methicillin, studies proved MRSA strains were resistant to macrolides, tetracyclines, chloramphenicol. Resistance to vancomycin was very evidently observed, and its transfer among the population and rising of resistant strains was becoming a major threat globally. The resistance of all these antimicrobial agents against the pathogenic microorganisms are taking a rise in some patients due to prolong use of the antimicrobial agents by these patients. The multi drug resistance has enhanced the mortality and morbidity rate which referred to the infecting agents as the “Super Bugs”. Survival of the microorganisms has increased due to the gradual development of extensive resistance against varied antimicrobial drugs. Possible treatments with combinations are found to be the only hope for infections against S. aureus. Few drugs are in development such as Dalbavancin, Oritavancin, Tigecycline. These are the possible treatments upon which the work is going on to reduce the resistance against the invasive MRSA. This chapter highlights the profiles of Staphylococcus aureus and the resistance patterns along with transmission and the role of the plasmid in transmitting the resistance.",signatures:"Riya Mukherjee, Anjali Priyadarshini, Ramendra Pati Pandey and Vethakkani Samuel Raj",downloadPdfUrl:"/chapter/pdf-download/75953",previewPdfUrl:"/chapter/pdf-preview/75953",authors:[{id:"332764",title:"Dr.",name:"Ramendra Pati",surname:"Pandey",slug:"ramendra-pati-pandey",fullName:"Ramendra Pati Pandey"},{id:"332768",title:"Prof.",name:"Vethakkani Samuel",surname:"Raj",slug:"vethakkani-samuel-raj",fullName:"Vethakkani Samuel Raj"},{id:"334752",title:"Dr.",name:"Anjali",surname:"Priyadarshini",slug:"anjali-priyadarshini",fullName:"Anjali Priyadarshini"},{id:"344188",title:"Ms.",name:"Riya",surname:"Mukherjee",slug:"riya-mukherjee",fullName:"Riya Mukherjee"}],corrections:null},{id:"75145",title:"Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence",doi:"10.5772/intechopen.96023",slug:"extracellular-vesicles-and-their-role-in-em-staphylococcus-aureus-em-resistance-and-virulence",totalDownloads:358,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Staphylococcus aureus is a pathogen of great importance to clinical and veterinary medicine. Recently, there has been a growing interest in S. aureus extracellular vesicles (EVs) in the pathogenesis of this bacterium. Released by living cells into the extracellular milieu, EVs are membranous structures carrying macromolecules such as proteins, nucleic acids, and metabolites. These structures play several physiological roles and are, among others, considered a mechanism of intercellular communication within S. aureus populations but also in trans kingdom interactions. S. aureus EVs were shown to transport important bacterial survival and virulence factors, such as β-lactamases, toxins, and proteins associated with bacterial adherence to host cells, and to trigger the production of cytokines and promote tissue inflammation. In this chapter, we will review the main studies regarding S. aureus EVs, including their composition and roles in host-pathogen interactions, and the possible applications of EVs for vaccines and therapy development against staphylococcal infections.",signatures:"Brenda Silva Rosa da Luz, Vasco Azevedo, Yves Le-loir and Eric Guedon",downloadPdfUrl:"/chapter/pdf-download/75145",previewPdfUrl:"/chapter/pdf-preview/75145",authors:[{id:"192132",title:"Dr.",name:"Vasco",surname:"Ariston de Carvalho Azevedo",slug:"vasco-ariston-de-carvalho-azevedo",fullName:"Vasco Ariston de Carvalho Azevedo"},{id:"334958",title:"MSc.",name:"Brenda",surname:"Silva Rosa da Luz",slug:"brenda-silva-rosa-da-luz",fullName:"Brenda Silva Rosa da Luz"},{id:"344089",title:"Dr.",name:"Yves",surname:"Le-Loir",slug:"yves-le-loir",fullName:"Yves Le-Loir"},{id:"344090",title:"Dr.",name:"Eric",surname:"Guédon",slug:"eric-guedon",fullName:"Eric Guédon"}],corrections:null},{id:"75300",title:"Staphylococcus aureus and Dairy Udder",doi:"10.5772/intechopen.95864",slug:"-em-staphylococcus-aureus-em-and-dairy-udder",totalDownloads:405,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus is a major causative agent of intra-mammary infections in dairy animals with potential virulence of surface components, toxins, and extracellular enzymes. About 74% quarter prevalence of S. aureus in bovine udder with overall prevalence exceeding 61% in dairy animals. About 17 different serotypes of dairy originated S. aureus have been reported with 24 virulence coding genes for leukocidins (lukED/lukM), pyrogenic toxin super antigen (PTSAg), haemolysins (hla-hlg), toxic-shock syndrome toxin (tst), enterotoxins (sea-seo, seu), exfoliative toxins (eta, etb), and genes for methicillin (mecA) and penicillin (blaZ) resistance. Attainment of refuge inside the macrophages and neutrophils is a major cause of S. aureus mastitis persistence. Mammary prebiotics and probiotics are recently being used as alternatives to antibiotic for the prevention of mastitis. Literature showed anti- staphylococcus vaccines with different results depending upon types of immunization, route of administration and adjuvant used. Studies has shown that herd specific as well as commercial S. aureus vaccines reduce new infections in dairy animals. Experiments are still in progress for the use of vaccines against S. aureus mastitis with optimal efficacy and reliability. Perhaps, there might be bright future because of highly satisfactory trial results of mastitis vaccines in the lab animals.",signatures:"Amjad Islam Aqib, Muhammad Ijaz, Muhammad Shoaib, Iqra Muzammil, Hafiz Iftikhar Hussain, Tean Zaheer, Rais Ahmed, Iqra Sarwar, Yasir Razzaq Khan and Muhammad Aamir Naseer",downloadPdfUrl:"/chapter/pdf-download/75300",previewPdfUrl:"/chapter/pdf-preview/75300",authors:[{id:"229220",title:"Dr.",name:"Amjad",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib"},{id:"269637",title:"Mr.",name:"Muhammad",surname:"Shoaib",slug:"muhammad-shoaib",fullName:"Muhammad Shoaib"},{id:"322861",title:"Dr.",name:"Tean",surname:"Zaheer",slug:"tean-zaheer",fullName:"Tean Zaheer"},{id:"333749",title:"Dr.",name:"Muhammad",surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz"},{id:"333750",title:"Dr.",name:"Iqra",surname:"Muzamil",slug:"iqra-muzamil",fullName:"Iqra Muzamil"},{id:"333751",title:"Dr.",name:"Aamir",surname:"Naseer",slug:"aamir-naseer",fullName:"Aamir Naseer"},{id:"333752",title:"Dr.",name:"Iftikhar",surname:"Hussain",slug:"iftikhar-hussain",fullName:"Iftikhar Hussain"},{id:"333753",title:"Dr.",name:"Rais",surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed"},{id:"333754",title:"Dr.",name:"Yasir",surname:"Razzaq Khan",slug:"yasir-razzaq-khan",fullName:"Yasir Razzaq Khan"},{id:"333755",title:"Dr.",name:"Iqra",surname:"Sarwar",slug:"iqra-sarwar",fullName:"Iqra Sarwar"}],corrections:null},{id:"79032",title:"Progression of β-Lactam Resistance in Staphylococcus aureus",doi:"10.5772/intechopen.100622",slug:"progression-of-lactam-resistance-in-em-staphylococcus-aureus-em-",totalDownloads:175,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus is a notorious human pathogen that causes superficial and invasive infections both in nosocomial and community-acquired settings. The prevalence of staphylococcal infections became more challenging after emerging resistance against topical antibiotics. S. aureus evolved resistance to β-lactam antibiotics due to modification and expression of penicillin-binding proteins (PBP), inactivation of drug by β-lactamase synthesis, limiting uptake of drug by biofilm formation, and reducing uptake by expression of efflux pump. The wave of resistance was first observed in penicillin by β-lactamase production and PBPs modification. The second wave of resistance emerged to methicillin by appearing methicillin-resistant S. aureus (MRSA) strains. Cephalosporin has long been used as the last resort for preventing MRSA infections, but resistant strains appeared during treatment. In progression to control MRSA or related infections, carbapenems have been used but strains developed resistance. S. aureus is among the high-priority resistance organisms that need renewed efforts for the research and development of new antibiotics and innovative preventive approaches. However, a lot of toiling is involved in devising an effective treatment against drug resistant S. aureus. This chapter aim is to retrospectively determine the progression of resistance in S. aureus, against different β-lactam antibiotics and their challenges of medication.",signatures:"Antresh Kumar and Manisha Kaushal",downloadPdfUrl:"/chapter/pdf-download/79032",previewPdfUrl:"/chapter/pdf-preview/79032",authors:[{id:"333046",title:"Associate Prof.",name:"Antresh",surname:"Kumar",slug:"antresh-kumar",fullName:"Antresh Kumar"},{id:"439834",title:"Dr.",name:"Manisha",surname:"Kaushal",slug:"manisha-kaushal",fullName:"Manisha Kaushal"}],corrections:null},{id:"71743",title:"Bacterial Skin Abscess",doi:"10.5772/intechopen.91657",slug:"bacterial-skin-abscess",totalDownloads:467,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Patients with skin and soft tissue infections may appear with the abscess. Erroneous diagnosis of these entities is common, and should carefully consider the possible alternative diagnoses. Risk for developing skin abscess factors includes disruption of the skin barrier, edema, venous insufficiency, and immune suppression. However, healthy individuals who have no risk factors may also develop these diseases. The most common microbiologic cause of abscess, a commonly group Streptococcus or Streptococcus pyogenes; Staphylococcus aureus (including methicillin-resistant strains) is a notable but less common cause. The most common microbiologic cause of skin abscess is S. aureus; a skin abscess can be caused by more than one pathogen. The diagnosis is based on skin abscess usually on the clinical manifestations. It must be subject to patients with disposable abscess incision and drainage, with a test of culture and susceptibility of materials wet. There is no justification for the blood of patients in the cultures of the abovementioned circumstances. It can be a useful radiographic examination to determine whether the skin abscess is present (via ultrasound) to distinguish cellulitis from osteomyelitis (via magnetic resonance imaging). There may be a justification for radiological assessment in patients with immune suppression, diabetes, venous insufficiency, or lymphedema in patients with persistent symptoms of systemic lymphatic obstruction.",signatures:"Mohammed Malih Radhi, Fatima Malik AL-Rubea, Nada Khazal Kadhim Hindi and Rusull Hamza Kh. AL-Jubori",downloadPdfUrl:"/chapter/pdf-download/71743",previewPdfUrl:"/chapter/pdf-preview/71743",authors:[{id:"307845",title:"Dr.",name:"Nada",surname:"Khazal Kadhim Hindi",slug:"nada-khazal-kadhim-hindi",fullName:"Nada Khazal Kadhim Hindi"},{id:"314292",title:"M.Sc.",name:"Mohammed",surname:"Malih Radhi",slug:"mohammed-malih-radhi",fullName:"Mohammed Malih Radhi"},{id:"319772",title:"Dr.",name:"Fatima",surname:"Malik AL-Rubea",slug:"fatima-malik-al-rubea",fullName:"Fatima Malik AL-Rubea"},{id:"319773",title:"Dr.",name:"Rusull",surname:"Hamza Kh. AL-Jubori",slug:"rusull-hamza-kh.-al-jubori",fullName:"Rusull Hamza Kh. AL-Jubori"}],corrections:null},{id:"77088",title:"Bacteriophages as Anti-Methicillin Resistant Staphylococcus aureus Agents",doi:"10.5772/intechopen.98313",slug:"bacteriophages-as-anti-methicillin-resistant-em-staphylococcus-aureus-em-agents",totalDownloads:256,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Staphylococcus aureus is a colonizing microorganism of the nasal region of both humans and animals and represents an important opportunistic pathogen. The acquisition of the mecA and mecC genes by S. aureus led to the emergence of methicillin resistance (MRSA), becoming a public health problem in both human and animal areas. In addition to resistance to β-lactam antibiotics, MRSA strains have multidrug resistance to antimicrobials, significantly limiting therapeutic options, making it crucial to have effective alternatives for treating staphylococcal infections. In this context, the use of lytic bacteriophages, which are viruses that infect and lyse bacteria, as well as the use of their by-products, such as endolysins, has shown potential in the control of S. aureus, including MRSA. Due to the specificity of bacteriophages to infect particular prokaryotic hosts, these viruses represent an antibacterial resource for the control of public health relevant microorganisms, especially antibiotic-resistant bacteria.",signatures:"Simone Ulrich Picoli, Nicole Mariele Santos Röhnelt and Tiago Sfredo Schenkel",downloadPdfUrl:"/chapter/pdf-download/77088",previewPdfUrl:"/chapter/pdf-preview/77088",authors:[{id:"334383",title:"Ph.D.",name:"Simone",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli"},{id:"335018",title:"MSc.",name:"Nicole",surname:"Mariele Santos Röhnelt",slug:"nicole-mariele-santos-rohnelt",fullName:"Nicole Mariele Santos Röhnelt"},{id:"335020",title:"BSc.",name:"Tiago",surname:"Sfredo Schenkel",slug:"tiago-sfredo-schenkel",fullName:"Tiago Sfredo Schenkel"}],corrections:null},{id:"79200",title:"Antimicrobial Resistance Leading to Develop Livestock-Associated Methicillin-Resistant S. aureus, and Its Impact on Human, Animal, and Environment",doi:"10.5772/intechopen.100169",slug:"antimicrobial-resistance-leading-to-develop-livestock-associated-methicillin-resistant-em-s-aureus-e",totalDownloads:77,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The most important microbe in humans is Staphylococcus aureus, which has caused worldwide dispersion in both nosocomial and community settings. The impact of Gram-positive Staphylococcus Aureuson the host is extremely detrimental to illness development. The life form is noteworthy for its ability to receive anti-toxin protection from a variety of anti-toxin classes. The development and distribution of methicillin-resistant Staphylococcus Aureus (MRSA) strains, which are generally multi-drug resistant in clinics and, as a result, in the population, cause severe mortality and bleakness. The research of MRSA illness transmission has advanced since its underlying event, which necessitates a complete clinical approach to dealing with take on this microorganism. For long term use drug of choice is vancomycine nevertheless its efficacy has been put to the test by rise in opposition. More modern anti-MRSA anti-infection medicines have been approved for clinical usage in the last 10 years or so. The aim of this chapter is to offer related data on the genus Staphylococcus and the evolution of antibiotic resistance in addition a discussion of the most important antibiotic resistance mechanisms. Although they are notorious for causing anti-infection blockage, there is a constant need for exploring innovative MRSA antagonists from various sources, including plants, and assessing non-anti-toxin draws close.",signatures:"Muhammad Farooq, Ifra Siddique and Zia Ullah",downloadPdfUrl:"/chapter/pdf-download/79200",previewPdfUrl:"/chapter/pdf-preview/79200",authors:[{id:"330652",title:"Dr.",name:"Muhammad",surname:"Farooq",slug:"muhammad-farooq",fullName:"Muhammad Farooq"},{id:"345279",title:"Ms.",name:"Ifra",surname:"Siddique",slug:"ifra-siddique",fullName:"Ifra Siddique"},{id:"345280",title:"Mr.",name:"Zia",surname:"Ullah",slug:"zia-ullah",fullName:"Zia Ullah"}],corrections:null},{id:"78759",title:"Staphylococcus aureus and the Veterinary Medicine",doi:"10.5772/intechopen.100202",slug:"-em-staphylococcus-aureus-em-and-the-veterinary-medicine",totalDownloads:208,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Staphylococcus aureus has vital importance in veterinary medicine. Within the ruminants, it is one of the major causes of mastitis, the problem that was and is, with no definite solution to date. Along with that, it also affects the health of animals, pets, and poultry in several ways as the tissue tropism for this organism in poultry is the bones and the joints. This review is focused on habitat, species differentiation, differential biochemical tests, pathogenesis, clinical infections, economic importance, public health significance, immune response, the regulation of virulence in the staphylococci, and cytokines response against S. aureus.",signatures:"Muhammad Farhab, Muhammad Tahir Aleem, Shakseema Shaukat, Ayesha Qadry, Muhammad Zeeshan Ul Haq, Fateh Ullah, Muhammad Jawad and Amjad Islam Aqib",downloadPdfUrl:"/chapter/pdf-download/78759",previewPdfUrl:"/chapter/pdf-preview/78759",authors:[{id:"229220",title:"Dr.",name:"Amjad",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib"},{id:"330412",title:"Dr.",name:"Muhammad",surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab"},{id:"330440",title:"Dr.",name:"Ayesha",surname:"Qadry",slug:"ayesha-qadry",fullName:"Ayesha Qadry"},{id:"435274",title:null,name:"Muhammad",surname:"Shahid Khan",slug:"muhammad-shahid-khan",fullName:"Muhammad Shahid Khan"},{id:"435275",title:"Dr.",name:"Muhammad",surname:"Tahir Aleem",slug:"muhammad-tahir-aleem",fullName:"Muhammad Tahir Aleem"},{id:"435276",title:null,name:"Shakseema",surname:"Shaukat",slug:"shakseema-shaukat",fullName:"Shakseema Shaukat"},{id:"435278",title:null,name:"Muhammad",surname:"Zeeshan Ul Haq",slug:"muhammad-zeeshan-ul-haq",fullName:"Muhammad Zeeshan Ul Haq"},{id:"435279",title:null,name:"Muhammad",surname:"Jawad",slug:"muhammad-jawad",fullName:"Muhammad Jawad"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:{id:"3",series:{id:"6",title:"Infectious Diseases",issn:"2631-6188",editor:{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. 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He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"11",institution:null}}},tags:null},relatedBooks:[{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"825",title:"Current Topics in Tropical Medicine",subtitle:null,isOpenForSubmission:!1,hash:"ef65e8eb7a2ada65f2bc939aa73009e3",slug:"current-topics-in-tropical-medicine",bookSignature:"Alfonso J. 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This book includes comprehensive information on fabrication, emerging physical properties, and technological applications of advanced carbon materials. Over three sections, chapters cover such topics as advanced carbon materials in engineering, conjugation of graphene with other 2D materials, fabrication of CNTs and their use in tissue engineering and orthopaedics, and advanced carbon materials for sustainable applications, among others.",isbn:"978-1-78985-924-9",printIsbn:"978-1-78985-912-6",pdfIsbn:"978-1-78985-991-1",doi:"10.5772/intechopen.92494",price:119,priceEur:129,priceUsd:155,slug:"21st-century-advanced-carbon-materials-for-engineering-applications-a-comprehensive-handbook",numberOfPages:130,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"712d04d43dbe1dca7dec9fcc08bc8852",bookSignature:"Mujtaba Ikram and Asghari Maqsood",publishedDate:"October 13th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10479.jpg",keywords:null,numberOfDownloads:1994,numberOfWosCitations:0,numberOfCrossrefCitations:4,numberOfDimensionsCitations:11,numberOfTotalCitations:15,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 28th 2020",dateEndSecondStepPublish:"September 25th 2020",dateEndThirdStepPublish:"November 24th 2020",dateEndFourthStepPublish:"February 12th 2021",dateEndFifthStepPublish:"April 13th 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:"Edited by",kuFlag:!1,biosketch:"A visiting scholar at the Abdus Salam International Center for Theoretical Physics (ICTP)-Italy from time to time, Dr. Ikram was selected among two young scientists from South Asia for TWAS science diplomacy, which was held in Trieste Italy 2013 and in 2015, he was also awarded CAS-TWAS green technology award followed by CAS-TWAS green chemistry and technology (GCT) award for his guest lectures in 2017.",coeditorOneBiosketch:"A dean of the Faculty of Basics and Applied Sciences, Air University, Islamabad, Pakistan with over 40 years of experience in research of advanced materials. Prof. Maqsood has 212 research publications, including 180 journal publications and 4 book chapters. She is a receiver of many national and international awards and is recognized widely for her scientific work.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",middleName:null,surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bReopQAC/Profile_Picture_1636383457578",biography:"Dr. Mujtaba Ikram has obtained his BS hons. (computational physics), MS (materials and surface engineering) and Ph.D. (material sciences and engineering), respectively. His research interests include nanotechnology, renewable energy, material science and engineering. His work has been cited by scientists from all over the world. He has authored/co- authored number of publications with 100+ cumulative impact factor in world prestigious journals as Advanced materials, RSC advances, Journal of Materials Chemistry C, RSC New Journal of chemistry, Chemcatchem, Journal of alloys and compounds, Applied nanoscience, International Journal of hydrogen energy, Journal of physics and chemistry of solids, Journals of solid state chemistry and many others. He has represented his research in the USA, Italy, Egypt, Germany, Slovenia, China, Hong Kong, Malaysia, UAE and many other countries. He has attended various research training/conferences/workshops on industrial physics, renewable energy, advanced carbon materials and nanotechnology in various parts of the world. He is a frequent visiting scholar at the Abdus Salam International center for theoretical physics (ICTP)-Italy. He has attended training on renewable and sustainable energy, which was organized by world prestigious national renewable energy lab (NREL)-USA and university of colorado at boulder-USA. He has attended AIP Industrial physics forum, ICTP- UNESCO-Italy conferences on energy co sponsored by American Institute of Physics (AIP), I-CAMP-colorado conference-USA, International conference on nanotechnology, biotechnology and spectroscopy (ICNBS)-Egypt, TWAS Energy science diplomacy Conference-Italy, International conference on advanced carbon Materials-Jinan-China and International ICTP nanosystems workshop-Italy. He was selected among two young scientists from south Asia for TWAS science diplomacy, which was held in Trieste Italy, 2013. He has been invited many times as Invited lecturer by CAS-TWAS Beijing. In 2015, he was awarded with CAS-TWAS green technology award. In 2017, he was awarded with CAS-TWAS green chemistry and technology (GCT) award for his guest lectures. He has been awarded with various world prestigious fellowships as CAS- TWAS presidential fellowship 2014, I-CAMP University of Colorado at boulder (USA) fellowship 2012, International center for theoretical physics (ICTP-Italy) participant fellowship (thrice), UNESCO fellowship for nano system workshop (Italy) 2013, Intercontinental advanced materials and photonics university of Cambridge (UK) participant fellowship 2013, Emerging nation science foundation (ENSF) travel fellowship 2012 and NUST foreign research presentation grant 2012.",institutionString:"University of the Punjab",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of the Punjab",institutionURL:null,country:{name:"Pakistan"}}}],coeditorOne:{id:"321219",title:"Dr.",name:"Asghari",middleName:null,surname:"Maqsood",slug:"asghari-maqsood",fullName:"Asghari Maqsood",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00002w6QhQQAU/Profile_Picture_1636447379567",biography:"Professor Emeritus Dr Asghari Maqsood is currently working as an advisor to the vice-chancellor, Air University, Islamabad, Pakistan, where she also served as a founding dean in the Faculty of Basics and Applied Sciences. She has more than forty-eight years of experience in the research of advanced materials. She obtained her MSc from Oxford University, and Ph.D. in Materials Science from Goteborg University, Sweden, along with a diploma from Uppsala University, Sweden. She has more than 250 research publications to her credit including more than 230 journal publications and 4 books, 5 chapters and one edited book.\r\nShe has arranged many international and national conferences and has presented her work as an invited speaker internationally in Bangladesh, China, Iran, Malaysia, Singapore, Sri Lanka, United Kingdom etc. She has been awarded many national and international awards including a Gold Medal from the Pakistan Academy of Sciences (2000), President’s Award for Pride of Performance (2001), HEC Best University Teacher Award (2002), Prime Minister Gold Medal (2004), Izaz-i-Fazeelat for Academic Distinction (2005), and Civil Award Sitara- e- Imtiaz (2010). Professor Maqsood is a fellow of Pakistan Academy of Sciences and Pakistan Nuclear Society. She has supervised more than 130 post graduate theses. Recently, her name appeared among the world's top 2% of scientists on a list by Stanford University, California, USA.",institutionString:"Air University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Air University",institutionURL:null,country:{name:"Pakistan"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"208",title:"Material Science",slug:"nanotechnology-and-nanomaterials-material-science"}],chapters:[{id:"74964",title:"Introductory Chapter: Introduction to Advanced Carbon Materials and Innovative Engineering Applications",slug:"introductory-chapter-introduction-to-advanced-carbon-materials-and-innovative-engineering-applicatio",totalDownloads:200,totalCrossrefCites:0,authors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba 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There is an agreement in research about democracy building (democratization) that the previous century consisted of major ideological battles. Scholars on democracy building have argued that the last decades of the twentieth century consisted of a spirit of democracy with a growing number of democratic states around the world. From the 1970s to the mid-1990s, a global spread of new democracies occurred in most regions of the world—except the Middle East—and challenged post-totalitarian and authoritarian states, military regimes and despotic leaders in Southern Europe, Latin America, Asia, Africa and Central and Eastern Europe. These political changes made scholars portray the global changes in terms of “the triumph of democracy,” [1] “the end of history,” [2] “the democratic revolution” [3] and how democracy had become “globalized” [4] as a third “universal language” aside from money and the Internet [5].
At the beginning of the twenty-first century, however, authoritarianism has gone global and is challenging democratic regimes and the notions of political rights and civil liberties around the world. Recent studies from the early 2000s and forward have pointed at a potentially worrisome trend in new types of authoritarianism and hybrid regimes [6] comprising both authoritarian and democratic institutions. This trend may have left the world community at a crossroads of democracy and authoritarianism. The global spread of democracies during the late twentieth century and the rise of authoritarianism in the early twenty-first century have raised an interest in understanding and explaining how to build democratic states around the world [7]. This study chapter sets out to understand how to build a democracy by identifying national and international favorable factors for democracy building. Section 2 after this introduction illustrates the global patterns of democracy building over time and is followed by Section 3 on the theoretical foundation of democracy. Sections 4 and 5 explain the favorable national and international factors for building democracy. Section 6 concludes this study.
In the early 1990s, studies on democracy building mushroomed, identifying how the number of democracies worldwide had become greater than ever before in modern history. About 25 years ago, Huntington [8] identified major democratic waves in political changes, going from dictatorships to electoral and liberal democracies. The transition processes to electoral democracies centered on the establishment of popular votes and an election as the main competition for office. The numerous transitions into electoral democracies around the world embedded the right to vote for competitive parties in free and fair elections where the electoral outcome was respected and assured based on checks and balances between a country’s judiciary, executive and legislative powers.
In the early 1990s, Huntington argued that the historical global spread of democratic transitions in the nineteenth and twentieth centuries could be described as waves of democracy building. A historical wave constituted numerous states around the world, all going through democratic changes within a specific period of time. In particular, a wave of democratic change included a larger group of transitions from nondemocratic (authoritarian) to democratic (electoral) regimes within a specified period of time, and this change outnumbered the reverse transitions into authoritarianism. The wave metaphor of global democratization had a great impact on the scholarly interests in the patterns of democratic change around the world. However, many scholars in the field of democratization raised concerns about how democratic regimes were defined, focusing only on free and fair elections (electoral fallacy), thereby disregarding other important democratic qualities, and the overlapping time periods of these waves of democratization [9]. Most scholars who focused on democracy building agreed, however, that Huntington shed light on important historical transformations [10] in a suggested “two steps forward and one step back” pattern. Huntington summarized the historical changes until the early 1990s in three waves of democratization and two reverse waves.
The first wave of democratization was the longest in terms of years covered (1828–1926). It was argued that the first wave began with the American and French revolutions and transplanted ideas of what democracy was all about and how democracy could be established. This wave of democratization included the spread of the political right to vote to new previously marginalized groups of society and to newly established states around the world, such as in the West, Australia and South America. The historical record showed how the first wave included democracy building in about 30 states after World War I. The wave of democratization did, however, halt and was reversed with the authoritarian and totalitarian ideologies developed in Germany, Italy and Japan during the 1930s and 1940s, which resulted in reverse democratic setbacks and authoritarian regimes in Eastern and Southern Europe, as well as in South America.
The second wave of democratization (1943–1962) lasted for a far shorter time compared to the first wave and was an outcome of the major international political changes of the balance of power that came with the end of World War II and the defeat and collapse of Nazism and fascism. The collapse of antidemocratic systems resulted in the expansion of new democracies in, for instance, West Germany, Austria, Japan, Turkey, Greece, Uruguay, Brazil, Costa Rica, Argentina, Colombia, Peru and Venezuela. The aftermath of the war became a window of opportunity for the new spread of democratic regimes, political rights and civil liberties in greater number of states, though primarily with the deviant cases in the communist states in foremost Eastern Europe and East Asia (China). It was the powerful role of the Soviet Union in a post-World War II context that eventually founded the reverse wave of authoritarianism and resulted in the consolidation of communism in the Eastern European states and in limited democracy in Latin American states and some East Asian states.
The third wave of democratization (1974–1991) was argued to have begun with transitions in Southern Europe in the early 1970s and ended with major democratic transformations in Eastern Europe as a result of a weakened and finally collapsed Soviet Union. Democratization began in Spain, Portugal and Greece and peaked with the transitions in communist ruled Poland, Czechoslovakia, Hungary and Romania and the independence of 15 new states. The third wave of democratic transitions was, however, global in a geographical scope, with numerous new democracies established in Latin America and Asia, outnumbering the previous authoritarian traditions of regimes around the world. The third wave had great global impact on the democratic political landscape. As stated, “the birth of more than ninety democracies in this period represents the greatest transformation of the way states are governed in the history of the world” [11], and as a consequence, many scholars perceived the twentieth century as the century of progress [12].
Though the academic community had spent decades of research on how to explain and foresee democratization, the third wave of democratization came as a surprise [13] and sparked greater interest in the geographical scope of transitions, the driving engines behind such democratic change and the possibilities of further democracy building within newly democratized states. Scholars agreed that the third wave was global in scope and how the numerous transitions actually led to the number of democratic regimes now outnumbering authoritarian regimes for the first time in human history. Both scholars and international politicians argued how democracy was a symbol of good governance and how the wave of democratic transitions had shown “the unabashed victory of economic and political liberalism” in the world [14]. The global victory of political liberalism was argued to consist of the democratic transitions that established government by the people based on popular free and fair elections in multi-party systems. For almost half a century, the scholarly world had argued that democracy was based on free and fair elections. In his famous study, Schumpeter [15] presented a minimal definition on democracy and became the founding father of a procedural definition of democracy. Schumpeter’s definition of an electoral democracy focused on competing political elites for power. From this perspective, democracy was perceived as a political tool for selecting politicians and how popular elections, as a core political procedure, were essential for the spread and consolidation of other crucial political rights and civil liberties often tied to democratic systems and societies.
In the early 2000s, however, a growing number of individual academic studies, think-tanks and statistical assessments on democratic freedoms identified new challenges to the previous global transitions embedded in the third wave of democratization. Though this has not yet been argued to be the signs of a third reverse wave of global authoritarianism, scholars have pointed out worrying signs of democratic challenges across the world. First, it has been argued that many transitional states have turned up as vague electoral democracies with authoritarian characteristics. They have had free and fair elections, but have continued to face political, economic and social obstacles that have had negative impacts on the democratization process. These obstacles have created political societies of democratic fuzziness where democratic patterns have been mixed with undemocratic ones. Such obstacles may be found in electoral democracies with patterns of restricted participation and liberties, electoral democracies influenced by the existence of personal rule and patron-client relationships, electoral democracies with the existence of human rights abuses, electoral democracies in which there is a massive and perhaps uncontrolled popular mobilization that challenges order and stability and/or electoral democracies where undemocratic actors, such as the military, continue to influence politics. All these democracies may have elections and may tolerate legal alternative parties in opposition to the ruling party, but they are challenged by other major problems that influence the democratization process and democratic stability [16]. Second, it has also been argued that we have seen an authoritarian surge in international affairs with greater activities among major authoritarian powers to contain democracy around the world. Aside from limiting democratic rights and liberties at home, authoritarian states have actively coordinated foreign policy actions to halt the global spread of democracy. Such authoritarian measures have included media initiatives to limit the impact of Western news around the world, political actions against pro-democracy and human rights’ organizations, such as in global and regional intergovernmental organizations, and in civil society. Altogether, “The extent of the authoritarian challenges forces us to confront the disconcerting prospect that the most influential antidemocratic regimes are no longer content simply to contain democracy. Instead, they want to roll it back by reversing advances dating from the time of the democratic surge” [17]. The increasing bulk of studies have presented different concepts to describe these challenged electoral democracies [18].
There has been a long and on-going scholarly discussion on how to define and measure democratic and nondemocratic regimes [19]. Democracy is a fuzzy and multifaceted concept. In the literature on building democracy, two conceptions of democracy are relevant; a minimalist and maximalist perspective. First, the minimalist perspective has defined democracy as an electoral democracy, focusing on the procedural system of institutions and the institutional mechanism of free and fair elections. An electoral democracy has embedded the procedure of free and fair elections in which political elites compete for political power and where the population uses the election to check the political power from wrong-doings. The scholarly studies on electoral democracy has stressed the importance of political procedure to ensure political rights and civil liberties, although the main focus from a minimalist perspective has been on the implementation of elections as a guarantee for the idea of government by the people. Such definition of democracy has been argued to provide scholars with the ability to make comparative studies on democracy-building in different states by analyzing if there are free and fair elections or not [20].
Second, the maximalist perspective has, in comparison to the minimalist perspective on electoral democracy, focused on a more substantive democracy embedding political rights and civil liberties beyond the procedure of free and fair elections. Such conceptualization of a liberal democracy has developed out of the notion of the “fallacy of electoralism” [21], meaning paying too much attention to the election and missing out on other important political rights and civil liberties in a democracy. It has been argued that the fallacy of electoralism may lead to the definition of states as democracies, although such states consist of nondemocratic traits. Although free and fair elections are important in democracies, focus on electoralism only is a too narrow perspective on what democracy is all about. The maximalist perspective has therefore introduced the definition of a liberal democracy, based on the procedural ingredients in an electoral democracy, but also including additional rights and liberties in, for example, minority rights, politically equality, freedom of belief, opinion, discussion, speech, publication and assembly, the rule of law and securing human rights, etc. [22]. It has been argued that three fundamental dimensions exist in a liberal democracy; high level of competition, participation and liberties. As summarized by Georg Sørensen,
“Meaningful and extensive competition among individuals and organized groups (especially political parties) for all effective positions of government power, at regular intervals and excluding the use of force.
A highly inclusive level of political participation in the selection of leaders and policies, at least through regular and fair elections, such that no major (adult) social group is excluded.
A level of civil and political liberties—freedom of expression, freedom of the press, freedom to form and join organizations—sufficient to ensure the integrity of political competition and participation” [23].
The minimalist perspective and the maximalist perspective on democracy have provided scholars on democratization with important theoretical notions of foundations of democracy. Overall, there has been a scholarly tradition to implement the minimalist definition of democracy when analyzing democracy-building, by focusing on free and fair election as an important mechanism to promote other political rights and civil liberties. This has resulted in the conclusion that building democracy is very much about institutionalizing free and fair elections. However, the scholarly studies on building liberal democracy have stressed the possibility and importance of further developing electoral democracies, beyond the free and fair elections, including political rights and civil liberties. Robert Dahl has presented a well-known conceptualization of a democracy (polyarchy). His definition of democracy may be seen as a midrange definition between a minimal and maximal definition of democracy. Dahl has presented two dimensions of a democracy in contestation and participation. First, contestation refers to structured political competition through free and fair elections and second, participation refers to the popular right to participate as voters and/or politicians. In his definition of democracy, eight important institutions are mentioned. These are freedom to form and join organizations, freedom of expression, right to vote, eligibility for public office, right of political leaders to compete for support and votes, alternative sources of information, free and fair elections and institutions for making government policies depend on votes and other expressions of preference. Although Dahl’s definition focuses on electoral procedures, contestation and participation also embed other political rights and civil liberties. To ensure the implementation of democracy in contestation and participation, it is argued that civil liberties are crucial. Such liberties are, for example, freedom to think, believe, worship, speak and publish one’s views as well as the freedom to form and join organizations among other things [24].
The scholarly discussion on definitions of democracy has come with studies on nondemocratic states. The process of democracy building starts in a nondemocratic environment which may be of different natures such as one-party-states, military regimes, dynastic rule, theocratic rule, tyranny, oligarchy, absolutism, despotism and monarchy, etc. The research on nondemocratic regimes has set out different types. At first, democracies stood in sharp contrast to the totalitarian type. The totalitarian regime was characterized as a regime-type enforcing state objectives and goals on society and citizens, by concentrating all power to the elite and by subordinating societal activities and people to the control of the regime. In sharp contrast to a democracy, the totalitarian society was defined as an atomized society with very limited independent political, economic, social and judicial institutions due to the total control by the regime through the use of propaganda and terror [25]. To uphold total control, research has come to stress the importance of the implementation of an official ideology, single mass party, secret police, full control of communication, monopoly of coercive methods and a central control of the economy [26]. Another and more common nondemocratic regime has been the authoritarian regime. The authoritarian regime, compared to the totalitarian, has said to have a limited official ideology that dictates societal sectors and with a less powerful, violent and controlling police. The authoritarian regime is also open for socioeconomic pluralism and to some degree political pluralism, although such pluralism is never allowed to become political influential and challenge the ruling political elites. It should, however, be stated that democracy-building is far easier to achieve in an authoritarian setting compared to a totalitarian one. This is due to the existing political institutions in an authoritarian society, the allowance of pluralism and political opposition and to the more limited use of state violence and terror compared to totalitarian systems.
The previous trends of democratic progress around the world, followed by recent pessimistic assessments of returning authoritarianism, have led to a redeveloped interest in how to build democracies worldwide. There is a long tradition of studying how to protect and promote democracy. The main focus has been to identify the explanatory factors or driving engines that encourage countries to transition to democracy and in how to consolidate new democracies to become stabile and enduring. There has been a dominating focus on national factors for the transitions to democracy. The research on explanatory factors for building democracy grew out of an increasing number of studies on domestic actors and structures of the 1950s and onward, focusing primarily on socioeconomic factors. This approach was tied to developmental studies and was referred to as the modernization school or the modernization thesis. One of the first and most important studies on economic development and its role in modernization was Dankwart Rostow’s
Over time, new studies began to explore a more complex picture of modernization and democratization by unfolding a more detailed understanding about what economic and social indicators could trigger democracy building. These studies did not question the importance of modernization for political development, but pinpointed the economic and social structures that are needed to be developed to see democratization. It was argued that democracy building was based on economic progress embedding improved infrastructure, higher levels of education, shared societal values and improved health, etc. The main point made was that modernization embedded social issues that became explanatory factors to democracy rather than just focusing on pure economic growth. States with economic growth could through political reforms to facilitate social structures that were beneficial for developing and consolidating democracy. In more recent decades of research done on the modernization thesis, economic progress leading to improved technology and the flow of information and knowledge has become new emphasized indicators for building democracy. The IT revolution has empowered people to engage in societal issues and provided people the tools to hold politicians and governments accountable for their decisions and actions, although research also stresses how authoritarian regimes may use new technology to haunt down political oppositions [29].
In addition, modernization was said to also impact the domestic class-structures. For instance, Moore [30], in the classical study
A second set of domestic factors to democracy aside from socioeconomic modernization includes the political culture. The perspective on political culture has referred to people’s aggregated political orientations/attitudes toward the political objects of a society, such as the institutions, politicians, norms and values. Such interest in political culture has also included the analysis of the political cultural in terms of existing religious and/or civilization codes within Protestantism, Catholicism, Confucianism and Islam [32].
The perspective on political culture was developed in the 1960s and onward and focused on issues of socialization and the political orientations in cognitive orientation (referring to the knowledge of and beliefs about the political system), affective orientation (feelings about the political system) and evaluation orientation (including commitment and support for political institutions and the values and judgements of system performances). One pivotal study for this tradition of approaches for democracy building was Almond and Verba’s
Other studies [34] about the role of political culture have focused on political culture as a multidimensional phenomenon and have measured people’s political support of political community, regime principles, regime performance, regime institutions and political actors. These studies have assessed that the overall citizens’ support of democracies is high around the world, but there are dissatisfied democrats in societies. Democracies embed an increasing tension between democratic values, which are highly supported, and the trust in existing democratic institutions, which is declining. It has been concluded that there is high confidence within established democracies regarding political objects in the political community and the regime principles, but less confidence and trust in regime performances, regime institutions and politicians. The reasons behind such tension may be the identified existing decline in social trust and civic engagement, failure in regime performances and constitutional design or cultural factors rooted in modernization and changing norms and values.
Important studies on modernization and shifting norms and values have added insight about potential explanatory factors and challenges for democracy. Inglehart [35] conducted the famous World Values Survey, assessing the patterns of political attitudes in states worldwide. From a comparative perspective and over a long period of time, this survey has analyzed political attitudes toward the political community, democracy as an ideal form of government and regime performance. This survey has identified a decreasing respect for political authorities—such as in, for example, the police and political parties—and such declining respects is explained in terms of shifts in cultural values among citizens promoted by globalization, cultural transformations and modernization. The modernization process has fundamentally transformed the political and cultural system from being previously based on religious beliefs to political institutions, rational behavior and post-materialist values of maximizing individual well-being. Such fundamental transformation of culture may explain the identified shifting support to important political objects of democracy.
The scholarly interest in and study of the aggregated attitudes of citizens toward political objects has been related to research focused on the role of the civil society. Research on civil society has concerned people’s attitudes in a society toward political objects and the articulation of such attitudes into organizations, associations, unions and interest clubs. One famous and now classical study on civil society is De Tocqueville’s
The growing bulk of studies over time on civil society and democracy has focused on the relationship between civil society and the state and has concluded a positive versus negative definition of a civil society. First, it has been argued that civil society may be a counter force to the state and, second, an arena or platform for civic education and participation [38]. The negative definition of a civil society refers to the counter force role a civil society may play in regulating and controlling the state and its performances. A civil society may function as an arena of civil society actors who balance the power of state institutions in relation to societal forces and who make sure that state’s institutions do not abuse their authority. On the other hand, the positive definition of the civil society refers to the assisting function civil society can have in relation to the state by providing an additional societal arena where citizens can meet, articulate, aggregate and associate freely and become aware of political life. A civil society may therefore contribute to ideas, expertise, norms and values and societal actions to alleviate the pressure on the state and to guide the state in new directions for policy-making. A civil society may therefore have different functions in a democracy and may be an essential part in a vital and consolidated democratic system.
A third and final set of identified domestic factors for democracy building—aside from socioeconomic factors and political culture—includes political institutions and the political role of domestic political elites and the masses. One of the first and most important studies about political institutions and democracy was written by Huntington:
Research on political factors for democracy has also focused on the specific type of institutions that best favor democratic progress and stability. Studies have explored how to design or institutionally structure democracies in the best way to promote democracy and have assessed parliamentarism versus presidentialism. Such focus has, to a high extent, been based on the scholarly contributions by Linz and his colleagues. In his study,
The research on political explanatory factors for democracy was developed further in the 1980s by focusing on political actors in building democracy. Such an approach was referred to as the transitology or the transition paradigm by stressing the importance of individual political actors in the transition to democracy. Previous studies about political explanatory factors had been foremost focused on structural conditions, while these new studies shed light on political actions taken by formal political actors and societal forces beyond the political system. O’Donnell et al. provided several studies in
The role of softliners was, to some extent, dependent on the role of societal forces beyond the political system. Studies on political actors and their preferences for building democracy also focused on two more groups of actors in the moderates and the radicals (revolutionaries) within the society outside the formal political system. It was argued that the radicals wanted to overthrow the illegitimate elite of hardliners and softliners, while the moderates were open to forging alliances with softliners within the elite to see democratic change. It was stressed in in these studies that the transition phase to democracy often began with a division between hardliners and softliners within the authoritarian regimes, but strategic linkages between elites and the societal masses were important. This combination of alliances within the political elite and the societal groups outside the political system was referred to as the game of transition. The game of transition to democracy could take different paths. Democracy may result based on a pact between the dominating elite and the opposing elite to build democracy, through a reform when the societal masses are stronger than the elites and would build democracy from the bottom up, but without using violence; through imposition when one group of the political elite mobilizes and uses violence to overthrow the regime (such elite is often the military); and finally, through revolution, when the societal masses (revolutionaries) are strong enough to overthrow the traditional ruling elite by violence. Most studies on the game of transition have stressed the importance of the pact transition for democracy. Such a path would ensure an orderly progress toward democracy based on compromises and the growing trust between powerful elites. This path, based on a pact-strategy between elites, also limits the number of people engaged in the transition, which is favorable for further democratization, as fewer people bring involved improves the chances of reaching compromises and does not led to an overload of political wants and demands. Further related studies on elites and masses have from an economic position argued that citizens prefer democratic systems due to the economic redistribution majority rule provide. This is in opposition to the elites that rather prefer nondemocratic political systems since they protect social and economic privileges and represent a favorable system of redistribution for the people in power. Transition to democracy may, however, happen if concessions from the elites are not credible and when repression and the use of violence are perceived as too risky and too costly [46].
The above-identified domestic-oriented perspectives on socioeconomic, cultural and political factors have provided explanations for democratization. The complementary perspectives of explanatory factors for democratization shed light on important driving engines for building democracies around the world and have enlightened the public and those in academic life regarding when democracy is likely to happen. The bulk of studies have been comprehensive, but these perspectives have contained one important flaw: the neglect to focus on international factors for democracy building. Until the 1990s, most research on how to build democracy focused on domestic factors. The dominance of domestic factors was primarily due to two phenomena. One explanation for the domestic bias in research on democratization is the construction of separating academic disciplines in comparative politics and international relations where research on how to build democracy belonged to the former. The tradition of comparative politics was to focus on domestic structures and actors to explain political situations and changes. Scholars in international relations, however, were less interested in domestic politics and focused on how states and other powerful actors engage in diplomatic, economic and political relationships with others and with what motives and impact they do so. Another explanation for the domestic bias in research has concerned the fuzzy idea of what really constitutes the international factors, reaching for any structures and/or actors in the world beyond the state’s territory. This has made potential international explanatory factors to democracy hard to pin down, which has left many scholars abandoning international perspectives on democracy building.
Some significant research efforts for identifying the international dimension to political change began in the 1960s. In a time of decolonization, a large number of studies focused on political and economic linkages and dependencies between developed and less-developed states. It was argued that international political and economic structures penetrated state borders and provided links between powerful and less-powerful actors. The notion of links and penetrated systems was especially explored among scholars within the dependency school, arguing that third-world states were influenced by rich states in the West based on an unjustified and unequal world economic structure. The criticism, however, pointed out the lack of specificity of how to analyze and understand international factors and how and when domestic politics and economics were influenced by or dictated by external forces.
It was argued that states were open systems vulnerable for penetration and that developed and powerful states could have a political impact on democracy building [47]. For instance, Rosenaue identified the link politics between the international and national domains as “any recurrent sequence of behavior that originates in one system and is reacted to in another” [48] and focused on the potential impact such links could have on democracy. In the 1990s, the debate about the international dimension re-emerged in the scholarly debate on globalization. The quickly growing number of studies about globalization covered the diffusion of global characteristics within economics, technology, culture and politics and stated a growing notion of interdependence in the world. It was further argued that economic, technological, cultural and political transformations across borders of intensification of interactions, exchanges and meetings led to a de-territorialization of politics in favor of macro-regional, international and global actors and processes. Globalization and global politics were portrayed as enhanced interdependence where global changes were cutting through state borders by challenging the domestic political, economic and cultural domestic structures by decreasing geographical distances around the world [49].
Research on the international dimension on democracy building, triggered by the studies on globalization, peaked with the end of the Cold War and with the increased power within the West. It resulted in the conceptualization of the international dimension to democracy in democratic diffusion and democratic promotion. First, the diffusion of democracy was argued to happen between nearby locations and between geographical locations far away with similar political, economic and cultural structures (or historical ties). It was stated that the spread of democracy was facilitated by political, cultural and economic salience often provided by geographical proximity, but diffusion could happen as a global phenomenon in a world of decreasing geographical distances. Diffusion of democracy was one important dimension of globalization—aside from the spread of economic liberalism and technology—and embedded the growing popularity of installing democratic governance [50]. The diffusion of democracy from one state or region to another required diffusion agents to assist the spread of democratic rights and liberties. Diffusion agents acted as socialization agents within the transnational networks and domestic domain, interpreting and introducing global norms and values to domestic settings.
A second international dimension factor for building democracy has been democracy promotion. Research on democracy promotion has been based on traditional insights from international relations and foreign policy-making, focusing on international actors’ motives and methods. The foreign policy analysis has displayed a growing interest in democracy promotion in which democracy promotion has referred to a foreign policy motivation to impact other governments and nations in a pro-democratic direction. Studies during the 1990s [51] argued that democracy promotion were essential factors for the global scope of democratization by identifying powerful actors, such as the European Union, the Organizations of Security and Cooperation in Europe and the United States, among others, and the declining power of Soviet Union. These actors promoted democratic ideas and encouraged governments and people around the world to launch democratic reforms, which led to transitions and, in the long run, snowballing effects on a growing number of states. The links between international democracy promotion and transitions were clarified through important research, such as in Pridham’s study:
Another impressive study on the international factors for democratization was Whitehead’s study,
Democracy refers to the government by the people. It ensures contestation and participation and provides citizens with political rights and civil liberties that promote popular freedom. Democratic systems have been challenged by nondemocratic systems and ideas over time. In the early twenty-first century, we have seen more democratic states than ever, with expanded freedoms in political rights and civil liberties, although an authoritarian upsurge is identified. Such authoritarian upsurge challenges electoral processes, political pluralism and participation, freedom of expression, associational and organizational rights and the rule of law, etc. This chapter has discussed the state-of-the-art research about factors favorable for building democracy in a time of authoritarian upsurge. So where do we stand today when we try to understand the possibilities and problems for democratic transitions? The research from the 1950s forward has developed explanatory factors for democracy building by pointing out national and international factors. This study identified the most important factors from a socioeconomic, cultural and political perspective. It was further argued that the international factors for democracy building, until recently, have constituted forgotten factors for democracy. This has been due to the comparative approach of most democratization studies and to the problems of conceptualizing international factors. However, this chapter presented two important international factors in democracy diffusion and democracy promotion. These factors complement the traditional domestic-oriented understandings of explanatory factors for democratization.
Based on decades of study about democracy building, contemporary research has continued to focus on national or international explanatory factors on the one hand and how links between the two groups of factors may interact on the other. Though international factors have come to play a much more important role in explaining transitions to democracy than before, today, it is the links between international democracy diffusion and democracy promotion and domestic salience that are in focus. This has led to a re-focus on political aelites and civil society actors as domestic democracy agents and gatekeepers in relation to external pro-democratic pressure. However, in a time of a reawakening of authoritarianism in the world, international pro-democratic forces are under heavy pressure from antidemocratic regimes. This has resulted in further studies on international politics regarding democratization and the balance of power between major states and international organizations and how certain states may be under international pressure and at a crossroads between democracy and authoritarianism. This has especially been the case in contemporary Eastern Europe and East Asia with the rising international power of Russia and China. Contemporary research on democracy building has become even more complex and requires scholarly collaboration between researchers belonging to comparative and international politics. It requires a firm understanding of national and international explanatory factors, but also how such factors may interact [56]. Based on previous research, long-term structural factors are important to build democracy. Such factors are economic prosperity, civil society activities, popular mobilization and political institutions. But actor-oriented factors are also crucial to understand democracy building in the short-run. It is foremost the different domestic elites and their perceptions, behavior and strategies that may provide window of opportunities for transitions to happen. In addition, national determinants to democratization must be linked to international factors in actors, structures and processes that penetrates state borders and may be prodemocratic or antidemocratic in nature.
Ever since our ancestors, humanity has been dependent on the consumption of plants as a source of food, health, and for construction/ornamental. In addition, plants have developed a complex defense system against biotic and antibiotic stress: therefore, they can produce diverse secondary metabolites (SMt). The stress to which plants are submitted under natural conditions is caused by different factors, among which stand out: attack by diverse insects and/or microorganisms (viruses, bacteria, and fungi) competition for soil, light, and nutrients, and exposure to sunlight [1].
SMt are compounds that do not play a fundamental role in the vital processes of plants, but they are important as mechanisms of defense. They are responsible for organoleptic and protective properties, such as odor, flavor, color, and consistency. These SMt also act as chemoattractants or chemorepellents. In addition, they are of great interest in industry for the preparation of food additives, agrochemicals, essences, biodiesel, narcotics, insecticides, cosmetics, and aromatics, and one of the most important of these is for the production of substances with pharmaceutical interest. Frequently, the production of SMt wild-collected plant is very low (less than 1% of the plant’s Dry Weight -DW-), and this depends specifically on the plant’s physiological state, the geographic location, the climate, among other factors [2].
Due to the low yield of SMt in wild plants and considering its important biological activity, alternatives or tools are currently being sought to increase its yield. One of these alternatives is the application of several biotechnology processes, a discipline that is oriented toward the development and innovation of technologies that involve the management of biological material for the production of a good or service [3].
One of the advantages in the use of biotechnological processes is to increase the production of bioactive SMt and also reduce the production time, which favors their availability [4]. The purpose of this paper is to summarize all the information that exists on the use of biotechnological processes for the production of bioactive compounds from Mexican medicinal plants.
Plants constitute a huge reservoir of chemical structures, the most economically important are medicinal plants, due to their diverse biological activities; which over the years have favored human survival thanks to their use in Traditional Medicine (TM) [5, 6, 7]. TM is widely used in some developing countries, where their health system is still growing and is of great economic importance. In Africa, up to 80% of the population employs TM to help satisfy its health needs. In Asia and in Latin America, the populations continue to use TM because of historical circumstances and cultural beliefs. In China, TM is of great importance due to the large percentage of population that utilizes it, being higher than 60%. In some developed countries, the percentage of the population that uses TM is 48% in Australia, 70% in Canada, 42% in the USA, 38% in Belgium and 75% in France [8].
Currently, Medicinal Plants (MP) are employed by 80% of the world population; therefore, these are overexploited not only because are source of active ingredients, also due to the high nutritional, wood, cosmetic, agricultural, and/or medicinal value that many of these have. For example, it is estimate that China exports 120,000 tons of MP and India, some 32,000 tons while Europe imports 400,000 tons of MP. This leads to overexploitation of the species and many of them are in danger of extinction [9, 10].
The World Conservation Union and the World Nature Fund report that there are between 350,000 and 550,000 species of MP in the world, of which only approximately 20% possess documented investigation of their biological potential, and nearly 15,000 species are in danger of extinction due to the overexploitation and destruction of habitats [10, 11].
Nowadays, scientific interest in MP has increased due to the high costs and adverse effects that allopathic drugs cause, in addition to the increasing appearance of strains of microorganisms that are resistant to current treatments [12, 13, 14]. It is noteworthy that almost 25% of the active principles of allopathic drugs currently used were isolated and/or semisynthesized from plants [9]. In modern medicine, digoxin is use as a cardiotonic and was isolated from
Guanidine is a natural product with good hypoglycemic activity that was isolated from
On the other hand, at present, the use of medicinal plants and/or phytodrugs is very frequent. The phytodrugs are elaborate with plant material and some derivatives of this. The main ingredient is the aerial or subterranean plant’s part; as well as extracts, tinctures, juices, resins, fatty acids, and essential oils presented in pharmaceutical form. The therapeutic effectiveness and safety have been confirmed scientifically [17]. Some examples of these include ginseng, it is obtained from Panax genus (
Due to the acceptance and growing use of phytodrugs around the world, PM are raw materials of great attention due to high consumption. In addition, MP biosynthesize several bioactive compounds, which are classified as terpenoids, alkaloids, lactones, flavonoids, coumarin, lignans and phenols, among others; many of these have restrictive taxonomical distribution. Although the SMt functions are not directly associated with the plant’s basic function, these compounds carry out some interaction roles in the plant and its environments such as: protection against pathogens, protection against abiotic tensions (ultraviolet radiation radiation), they possess the function of attracting pollinating insects, and they are signaling molecules and active ingredients for drugs [23, 24, 25].
It is estimated that around 50% of the drugs approved by the Federal Drug Administration are products derived from natural sources or analogs deriving from plants or microorganisms [26]. However, raw material can be limited, and its exploitation is one of the main ecological concerns. One of the key objectives of plant biotechnology is the development of large-scale production methods of pharmacologically active products. Additionally, the massive biosynthetic potential of plants has not been completely exploited yet and biotechnology can be employed to generate new chemical compounds that possess unknown biological activities and/or with a different mechanism of action, or a better one, than those in existence [23].
There are distinct strategies to optimize the production and modulation SMt in medicinal plants and food. The main strategies are by uses the elicitors (molecules capable of inducing defense in the plant) [1], which are classified as biotic and abiotic. Biotics are of biological origin, while abiotics can be physical or chemical. Some examples of physical abiotics are the weather, bacteria, and plagues, among others, while chemical abiotics possess an intense variety, with those most utilized being jasmonic acid and salicylic acid [27, 28]. One of the advantages of using elicitors treatment is that they function as signaling compounds for the mechanisms of defense; thus, they increase the production of SMt in an effective and rapid manner [29]. There is great specify in the interaction of plant-elicitor species which implies that the adequate one for each culture, the time of adding it, and the concentration for obtaining best response should be selected [30].
There is other technique very used to obtain SMt
In general, formulation of the culture medium begins with the base medium, being the most utilized Muashige & Skoog (MS), B5 of Gamborg and Linsmaier and Skoog (LS), and Nitsch and Nitsch (NN) [32]. These culture mediums contain minerals, vitamins, and a carbon source, normally sucrose and sometimes fructose is used. Although plant cell cultures typically are initiate in solid medium, they require liquid medium for production on a large scale. The mineral content and/or the carbon source in culture medium have a profound impact on biosynthesis of SMt employed in the manufacturing of phytodrugs and/or compound-of-pharmaceutical-interest [33].
Other tools very used to obtain SMt by biotechnological process is through the use of BioCatalyzers; this method has been used to transform polyphenols compounds; for example,
Chemical structure of some polyphenols and other SMt with biological activity.
Recently, interest in research and development of
In Table 1 and Figure 1, some examples are described. It is important to mention that on some occasions is difficult to establish the biotechnological process conditions to induce the biosynthesis of bioactive SMt from a MP.
Species | Products | Use | References |
---|---|---|---|
Alkaloids | Antimicrobial | [35] | |
Antocyanins | Antioxidant | [36, 37] | |
Cantinones alkaloids | Antimicrobial | [38] | |
Coumarins | Anticoagulant | [39] | |
Rosmarinic acid | Antioxidant | [40, 41] | |
Rosmarinic acid and Glycosides | Antioxidant | [42] | |
Piceatannol | Antioxidant | [43] | |
Artemisinin | Antimalaric | [30, 44] | |
Flavonoids | Antioxidant | [45] | |
Dehydrodiisoeugenol | Biocatalyst | [34] | |
Betalains | Antioxidant | [46, 47] | |
Verbascoside ( | Anti-inflammatory, antioxidant | [48] | |
Phenylpropanoids | Antioxidant | [49] | |
Homo isoflavones | Antimicrobial, antitumoral | [50] | |
Dipyranocoumarins | AntiHIV | [51] | |
Thiamine or theanine | Antihypertensive | [52] | |
Capsaicin ( | Irritant | [53] | |
Antraquinones | Antimicrobial | [54] | |
Verbascoside ( | Anti-inflammatory, Antispasmodics | [55] | |
Ajmalicin | Antihypertensive | [56] | |
Vinblastin | Anticancer | [57] | |
Chlorogenic acid, Isoorientin | Hypoglycemic | [58] | |
Emetin | Antiparasitic | [59] | |
Abietane diterpenoids | Antitumoral | [60] | |
Furanocoumarins | Antitumoral, Antioxidant | [61] | |
Furoquinolin alkaloids | Antitumoral, Antimicrobial | [62] | |
Robustaquiones | Antimalarial | [63] | |
Glycosides | Antioxidant | [64] | |
Glucophenyletanoids | Aphrodisiac | [65] | |
Colchicine ( | Antitumoral | [66] | |
Forskolin ( | Asthma | [67] | |
Camptotecin ( | Antitumoral | [68] | |
Berberin ( | Intestinal infection | [69] | |
β-glucogallin, (+)-Catechin, (+)-gallocatechin, procyanidin B-3 | Hyperglycemic and antimicrobial | [70] | |
Berberin | Antioxidant, Antidiabetic | [71] | |
Crocin | Anticancer | [72] | |
Cinarin, Chlorogenic acid | Antioxidant | [73] | |
Antocyanins | Lipoperoxidation | [74] | |
Digoxin ( | Cardiostimulant | [75] | |
Diosgenin ( | Steroidal stimulant | [76] | |
Plumbagin ( | Anticancer, Antimicrobial | [77] | |
Eleuteroside | Anti-inflammatory, diuretic, analgesic, antipyretic | [78] | |
Triterpenes | Anti-inflammatory, antidiabetic, antitumoral | [79] | |
Chlorogenic acid ( | Antimicrobial, Antioxidant | [80] | |
Rutin ( | Antioxidant | [81] | |
Antocyanins | Antioxidant | [82] | |
Galphimine B ( | Central nervous system disorders | [83] | |
Antocyanins | Antioxidant | [84, 85] | |
Gymnemicanor | Antidiabetic | [86] | |
Inulin | Antidiabetic | [87] | |
Rutin ( | Antioxidant | [88] | |
Hypericin | Antidepressive | [89] | |
Rosmarinic acid ( | Antioxidant | [90] | |
Lithospermic acid | Antioxidant | [91] | |
Antocyanins | Antioxidant | [92, 93, 94] | |
Nordihydroguayaretic acid, Quercetin | Antiarthritic, digestive, against venereal diseases | [95] | |
Rosmarinic acid ( | Hepatoprotective | [96, 97] | |
Coumarins, lactones, flavonids | Antioxidants | [98] | |
Shikonin | Antibacterial | [99] | |
6-O-palmitoyl-3-O-β-D-glucopyra-nosylcampesterol, 6-O-palmi-toyl-3-O-β-D-gluco-pyranosyl-β-sitosterol | Anti-inflammatory | [100] | |
Cerebroside | Cellular Growth Regulator | [101] | |
Antraquinones | Antimicrobial | [102] | |
L-dihydroxyphenylalanine | AntiParkinson | [103] | |
Elipticin | Antitumoral | [104] | |
Rosmarinic acid ( | Antioxidant | [105] | |
Ginkgolides ( | Cognitive deterioration | [106] | |
Ginsenosides ( | Immunomodulator | [107] | |
Codeine ( | Sedative | [108] | |
Morphine ( | Sedative | [109] | |
Sanguinarin ( | Platelet stimulator | [110] | |
Orientin, Isoorientin, Vitexin, Isovitexin | Antioxidant | [111] | |
Flavonolides | Antioxidant | [112] | |
Cuasin | Antiphylogistic | [113] | |
Monoterpene | Antifungal | [114] | |
Podophylotoxin ( | Antitumoral | [115] | |
Genistein and Daidzein | Tonic | [116] | |
Reserpin ( | Antihypertensive | [117] | |
Antraquin-ones | Antimicrobial | [118] | |
Cryptotanshinone | Antioxidant, antimicrobial | [119] | |
Tanshinone | Cardiac problems | [120] | |
Hispiduline ( | Antitumoral | [121] | |
Silymarin | Hepatoprotective | [122] | |
Cholecalcipherol | Aids calcium absorption | [123] | |
Sphaeralcic acid ( | Antiinflammatory | [124] | |
Alkaloids | Cytotoxic | [125] | |
Parthenolide ( | Anticancer | [126] | |
Taxol ( | Anticancer | [127] | |
Antocyanins | Antioxidant | [128] | |
Resveratrol ( | Antioxidant, Hepatoprotective | [129] | |
Withanolide A | Antioxidant, Antistress | [130] |
Secondary metabolites obtained for cellular cultures from medicinal plant tissues
Some SMt with significant anti-inflammatory activity have been obtain from MP through employment some biotechnological processes. From cell suspension cultures
In another study, the anti-inflammatory activity of the cell suspension culture from
In parallel with obtaining cells
Another plant utilized in Mexican ethnomedicine is
The lipophilic extract containing beta-carotene (LMBC) from plant cell cultures of
From the callus culture of
A first step was to obtain callus from hypocotyl explants in MS medium for 30 days with a combination of NAA and KIN; under these conditions, only great cell growth was obtained, and with 2,4-D at 4 mg/L the G-B production was stimulated with a yield of 0.154 mg/g DW. In addition, under this condition, G-E was also obtained but at less concentration (0.057 mg/g DW). Also, friable callus from suspension culture in MS medium with NAA and KIN (2:2 mg/L) was obtain, denominating this line as ggxl. By means of a growth kinetic, galphimines were shown to be produced in the culture’s stationary stage [83, 145]. The next step was to carry out the scaling of galphimine production in the 5-liter
Aqueous extract from material obtained by bioreactor was prepared, whose galphamine content was G-A, G-B and G-E = 0.6, 1.034 mg/g, and 1.12 mg/g, respectively. Meanwhile, the content of these galphamine in the ethanolic extract was G-A = 5.35 mg/g, G-B = 18.8 mg/g, and G-E = 17.49 mg/g and the MeOH extract content G-A = 7.29 mg/g, G-B = 17.47 mg/g, and G-E = 11.6 mg/g. Afterward, each extract was administered to Balb/C male and female mice for 28 days (2.5 g/kg). During the study period, there were no deaths, and in the histopathological analysis of the different organs; the latter did not present alterations. Also, analyzed the behavioral parameters, demonstrating a reduction in spontaneous activity. Administration of these extracts for 56 days (2.5 g/kg) in mice did not cause any change in liver-function biochemical parameters. With regard to the cytotoxic evaluation in KB, UISO, and OVCAR-5 cell lines, no cytotoxic effects were found, but all of these extracts specifically inhibited growth of the colon-cancer cell line with ED50 of <2 μg/mL. On the genotoxicity test
The anxiolytic and anti-depressive effects were evaluated for the
The MP form part of the daily life of the worldwide population. It is currently of scientific interest due to its high consumption, as an alternative treatment and/or co-administered with allopathic treatments for the improvement of chronic-degenerative diseases. On the other hand, the population has been responsible for affording a great boost to the use of MP; therefore, its consumption generates a great demand and consequently overexploitation. This overexploitation is a danger in the extinction of species of pharmaceutical interest. Another problem regarding the consumption of MP is that not all the population has access to species that are endemic and that have great biological potential. All the above led to the search for methods to achieve the production and induction of SMt biosynthesis with important biological activity in less time, with constant, controlled and standardized production. Besides helping to preserve plant species without altering the ecosystem.
In some cases, has been reported that cell suspension cultures increase by up to 300% the production of SMt with biological interest respect to wild plant material. In addition, to the increase in SMt production, these are obtained in less complex mixtures, which facilitates the purification process. In the present work, we describe several SMt obtained for biotechnological processing; however, many of these SMt have not been submitted to
Susan Drier for English language corrections.
This manuscript is a review and we did not have funding.
The author declare no competing interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
SMt | Secondary Metabolites |
SMBB | Sociedad Mexicana de Biotecnología y Bioingeniería |
TM | Tradicional Medicine |
MP | Medicinal Plants |
DNA | Deoxyribonucleic acid |
PGR | Plany Growth Regulators |
BioC | BioCatalyzers |
TPA | 12-O-Tetradecanoyl Phorbol 13-Acetate |
ED50 | Half of the Effective Dose |
NAA | Naphthalene Acetic Acid |
KIN | Kinetina |
2,4-D | Dichlophenoxiacetic acid |
BAP | 6-BenzylAminoPurine |
IC50 | Hal-maximal Inhibitory concentration |
DM | Dry Metter |
LD50 | Half of a Lethal Dose |
DW | Dry Metter |
CC50 | Mean Cytotoxic Concentration |
i.p. | Intraperitoneal |
S.C. | Subcutaneous |
G-A | Galphimine A |
G-B | Galphimine B |
G-E | Galphimine E |
C.N | Kinetine |
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Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"58868",doi:"10.5772/intechopen.73164",title:"Iron Ore Pelletizing Process: An Overview",slug:"iron-ore-pelletizing-process-an-overview",totalDownloads:4757,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"The iron ore production has significantly expanded in recent years, owing to increasing steel demands in developing countries. However, the content of iron in ore deposits has deteriorated and low-grade iron ore has been processed. The fines resulting from the concentration process must be agglomerated for use in iron and steelmaking. This chapter shows the status of the pelletizing process with a special focus on binders. Bentonite is the most used binder due to favorable mechanical and metallurgical pellet properties, but it contains impurities especially silica and alumina. The importance of many researches concerning alternative binders is also discussed in this chapter. Better quality wet, dry, preheated, and fired pellets can be produced with combined binders, such as organic and inorganic salts, when compared with bentonite-bonded pellets. While organic binders provide sufficient wet and dry pellet strengths, inorganic salts provide the required preheated and fired pellet strengths.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Sandra Lúcia de Moraes, José Renato Baptista de Lima and Tiago\nRamos Ribeiro",authors:[{id:"216788",title:"Dr.",name:"Sandra",middleName:"Lúcia",surname:"De Moraes",slug:"sandra-de-moraes",fullName:"Sandra De Moraes"},{id:"233466",title:"Prof.",name:"José Renato Baptista",middleName:null,surname:"De Lima",slug:"jose-renato-baptista-de-lima",fullName:"José Renato Baptista De Lima"},{id:"233467",title:"MSc.",name:"Tiago Ramos",middleName:null,surname:"Ribeiro",slug:"tiago-ramos-ribeiro",fullName:"Tiago Ramos Ribeiro"}]},{id:"54395",doi:"10.5772/67514",title:"Fundamentals of Chemical Vapor Deposited Graphene and Emerging Applications",slug:"fundamentals-of-chemical-vapor-deposited-graphene-and-emerging-applications",totalDownloads:3595,totalCrossrefCites:5,totalDimensionsCites:15,abstract:"Graphene, the atomically thin sheet of sp2 hybridized carbon atoms arranged in honeycomb structure, is becoming the forefront of material research. The chemical vapor deposition (CVD) process has been explored significantly to synthesis large size single crystals and uniform films of monolayer and bilayer graphene. In this prospect, the nucleation and growth mechanism of graphene on a catalytic substrate play the fundamental role on the control growth of layers and large domain. The transition metals and their alloys have been recognized as the active catalyst for growth of monolayer and bilayer graphene, where the surface composition of such catalysts also plays critical role on graphene growth. CVD-synthesized graphene has been integrated with bulk semiconductors such as Si and GaN for the fabrication of solar cells, photodetectors, and light-emitting diodes. Furthermore, CVD graphene has been integrated with hexagonal boron nitride (hBN) and transition metal dichalcogenides (TMDCs) for the fabrication of van der Waals heterostructure for nanoelectronic, optoelectronic, energy devices, and other emerging technologies. The fundamental of the graphene growth process by a CVD technique and various emerging applications in heterostructure devices is discussed in detail.",book:{id:"6215",slug:"graphene-materials-advanced-applications",title:"Graphene Materials",fullTitle:"Graphene Materials - Advanced Applications"},signatures:"Golap Kalita and Masaki Tanemura",authors:[{id:"17333",title:"Dr.",name:"Masaki",middleName:null,surname:"Tanemura",slug:"masaki-tanemura",fullName:"Masaki Tanemura"},{id:"195869",title:"Dr.",name:"Golap",middleName:null,surname:"Kalita",slug:"golap-kalita",fullName:"Golap Kalita"}]},{id:"37838",doi:"10.5772/50998",title:"Applications of SiC-Based Thin Films in Electronic and MEMS Devices",slug:"applications-of-sic-based-thin-films-in-electronic-and-mems-devices",totalDownloads:4146,totalCrossrefCites:0,totalDimensionsCites:13,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Mariana Amorim Fraga, Rodrigo Sávio Pessoa, Marcos Massi and Homero Santiago Maciel",authors:[{id:"38456",title:"Dr.",name:"Mariana",middleName:null,surname:"Amorim Fraga",slug:"mariana-amorim-fraga",fullName:"Mariana Amorim Fraga"},{id:"53494",title:"Dr.",name:"Rodrigo",middleName:"Savio",surname:"Pessoa",slug:"rodrigo-pessoa",fullName:"Rodrigo Pessoa"},{id:"91253",title:"Dr.",name:"Homero",middleName:"Santiago",surname:"Maciel",slug:"homero-maciel",fullName:"Homero Maciel"},{id:"91254",title:"Dr.",name:"Marcos",middleName:null,surname:"Massi",slug:"marcos-massi",fullName:"Marcos Massi"}]},{id:"39648",doi:"10.5772/51514",title:"Fundamental Aspects of Silicon Carbide Oxidation",slug:"fundamental-aspects-of-silicon-carbide-oxidation",totalDownloads:4439,totalCrossrefCites:6,totalDimensionsCites:13,abstract:null,book:{id:"3129",slug:"physics-and-technology-of-silicon-carbide-devices",title:"Physics and Technology of Silicon Carbide Devices",fullTitle:"Physics and Technology of Silicon Carbide Devices"},signatures:"Heiji Watanabe and Takuji Hosoi",authors:[{id:"153696",title:"Prof.",name:"Heiji",middleName:null,surname:"Watanabe",slug:"heiji-watanabe",fullName:"Heiji Watanabe"}]}],mostDownloadedChaptersLast30Days:[{id:"58868",title:"Iron Ore Pelletizing Process: An Overview",slug:"iron-ore-pelletizing-process-an-overview",totalDownloads:4757,totalCrossrefCites:7,totalDimensionsCites:16,abstract:"The iron ore production has significantly expanded in recent years, owing to increasing steel demands in developing countries. However, the content of iron in ore deposits has deteriorated and low-grade iron ore has been processed. The fines resulting from the concentration process must be agglomerated for use in iron and steelmaking. This chapter shows the status of the pelletizing process with a special focus on binders. Bentonite is the most used binder due to favorable mechanical and metallurgical pellet properties, but it contains impurities especially silica and alumina. The importance of many researches concerning alternative binders is also discussed in this chapter. Better quality wet, dry, preheated, and fired pellets can be produced with combined binders, such as organic and inorganic salts, when compared with bentonite-bonded pellets. While organic binders provide sufficient wet and dry pellet strengths, inorganic salts provide the required preheated and fired pellet strengths.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Sandra Lúcia de Moraes, José Renato Baptista de Lima and Tiago\nRamos Ribeiro",authors:[{id:"216788",title:"Dr.",name:"Sandra",middleName:"Lúcia",surname:"De Moraes",slug:"sandra-de-moraes",fullName:"Sandra De Moraes"},{id:"233466",title:"Prof.",name:"José Renato Baptista",middleName:null,surname:"De Lima",slug:"jose-renato-baptista-de-lima",fullName:"José Renato Baptista De Lima"},{id:"233467",title:"MSc.",name:"Tiago Ramos",middleName:null,surname:"Ribeiro",slug:"tiago-ramos-ribeiro",fullName:"Tiago Ramos Ribeiro"}]},{id:"58937",title:"Intermetallics Formation and Their Effect on Mechanical Properties of Al-Si-X Alloys",slug:"intermetallics-formation-and-their-effect-on-mechanical-properties-of-al-si-x-alloys",totalDownloads:1993,totalCrossrefCites:12,totalDimensionsCites:25,abstract:"This study focuses on primary impurities, called intermetallics, in the microstructure of Al-Si-X alloys, their formation, effects and treatments to eliminate or ameliorate their deleterious effects. Intermetallic compounds are usually formed when alloying elements, such as Fe, Cu, Mn, Mg and Sr. are added to Al-Si based alloys. These elements are depicted by X in the alloys formation expression. The chapter noted that the most common intermetallics are iron (Fe) based, and several of these Fe-phases, including the most harmful Fe-phase, β-Al5SiFe, are listed and discussed. Fe-phase intermetallics are deleterious to the mechanical properties of Al-alloys; however, addition of <0.7% Fe helps prevent soldering in die casting mould. The effects of Fe-phase and other intermetallics formed by Cu, Mg and Mn were examined. Further, some techniques of eliminating or mitigating the negative influences of intermetallics were discussed.",book:{id:"6134",slug:"intermetallic-compounds-formation-and-applications",title:"Intermetallic Compounds",fullTitle:"Intermetallic Compounds - Formation and Applications"},signatures:"Williams S. Ebhota and Tien-Chien Jen",authors:[{id:"206268",title:"Dr.",name:"Williams",middleName:"S.",surname:"Ebhota",slug:"williams-ebhota",fullName:"Williams Ebhota"},{id:"214786",title:"Prof.",name:"Tien-Chien",middleName:null,surname:"Jen",slug:"tien-chien-jen",fullName:"Tien-Chien Jen"}]},{id:"54372",title:"Photoinduced Pseudospin Dynamical Effects in Graphene-Like Systems",slug:"photoinduced-pseudospin-dynamical-effects-in-graphene-like-systems",totalDownloads:1694,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"In this chapter, we describe some of our recent results on the laser-induced manipulation of the energy band structure of graphene-like systems. We present numerical results on the quasi-energy spectrum as well as detailed calculations of semi-analytical approximations to other physical quantities of interest. The main message we would like to convey to the interested reader of the chapter is that by properly tuning the perturbation parameters of the radiation field one can control the size and shape of the photoinduced gaps. These in turn would allow the realization of new electronic phases on graphene and its related materials such as silicene.",book:{id:"5722",slug:"graphene-materials-structure-properties-and-modifications",title:"Graphene Materials",fullTitle:"Graphene Materials - Structure, Properties and Modifications"},signatures:"Alexander López and Benjamin Santos",authors:[{id:"195536",title:"Dr.",name:"Alexander",middleName:null,surname:"López",slug:"alexander-lopez",fullName:"Alexander López"},{id:"204551",title:"MSc.",name:"Benjamin",middleName:null,surname:"Santos",slug:"benjamin-santos",fullName:"Benjamin Santos"}]},{id:"58482",title:"Calcination and Pelletizing of Siderite Ore",slug:"calcination-and-pelletizing-of-siderite-ore",totalDownloads:1339,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"In the present study, calcination properties of Hekimhan-Deveci siderite (FeCO3) ore and the effect of calcination process before the pelletization on strength of pellet were investigated and evaluated. Two different calcination processes were followed. One of them is the traditional calcination process and the other one is microwave assisted calcination process which is a new process for siderite ore. The characterization of the calcined and uncalcined siderite ore was done using X-ray diffraction, X-ray fluorescence spectrometry and thermogravimetric analysis. The physical and mechanical properties of pellets which were obtained using the raw siderite and the calcined siderite were compared with each other. As a result of experimental studies, it was found that the calcination process decreased the milling time, causing the significant energy saving and the most suitable calcination process for siderite ore was found as 15 min at 700°C temperature. It was the first time that the calcination process of the siderite ore was achieved by microwave by adding 30 wt% sucrose as a thermal auxiliary. The microwave conditions were determined as 900 W at 3 min. In 3 min, the temperature of the siderite ore increased up to 1100°C and 32.14% weight loss for the sample was achieved.",book:{id:"6335",slug:"iron-ores-and-iron-oxide-materials",title:"Iron Ores and Iron Oxide Materials",fullTitle:"Iron Ores and Iron Oxide Materials"},signatures:"Mehmet Celikdemir, Musa Sarikaya, Tolga Depci, Ramazan\nAydogmus and Aysegul Yucel",authors:[{id:"212301",title:"M.Sc.",name:"Mehmet",middleName:null,surname:"Çelikdemir",slug:"mehmet-celikdemir",fullName:"Mehmet Çelikdemir"},{id:"213405",title:"Prof.",name:"Musa",middleName:null,surname:"Sarikaya",slug:"musa-sarikaya",fullName:"Musa Sarikaya"},{id:"213412",title:"Prof.",name:"Tolga",middleName:null,surname:"Depci",slug:"tolga-depci",fullName:"Tolga Depci"},{id:"213413",title:"MSc.",name:"Ramazan",middleName:null,surname:"Aydoğmuş",slug:"ramazan-aydogmus",fullName:"Ramazan Aydoğmuş"},{id:"227119",title:"MSc.",name:"Ayşegül",middleName:null,surname:"Yücel",slug:"aysegul-yucel",fullName:"Ayşegül Yücel"}]},{id:"69224",title:"Introductory Chapter: Cobalt Compounds and Applications",slug:"introductory-chapter-cobalt-compounds-and-applications",totalDownloads:812,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"8886",slug:"cobalt-compounds-and-applications",title:"Cobalt Compounds and Applications",fullTitle:"Cobalt Compounds and Applications"},signatures:"Aynur Manzak and Yasemin Yildiz",authors:[{id:"208129",title:"Dr.",name:"Yasemin",middleName:null,surname:"Yıldız",slug:"yasemin-yildiz",fullName:"Yasemin Yıldız"}]}],onlineFirstChaptersFilter:{topicId:"950",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:126,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:13,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Rosa María Martínez-Espinosa is a Full Professor of Biochemistry and Molecular Biology at the University of Alicante, Spain, and has been the vice president of International Relations and Development Cooperation at this university since 2010. She created the research group in applied biochemistry in 2017 (https://web.ua.es/en/appbiochem/), and from 1999 to the present has made more than 200 contributions to Spanish and international conferences. Furthermore, she has around seventy-five scientific publications in indexed journals, eighty book chapters, and one patent to her credit. Her research work focuses on microbial metabolism (particularly on extremophile microorganisms), purification and characterization of enzymes with potential industrial and biotechnological applications, protocol optimization for genetically manipulating microorganisms, gene regulation characterization, carotenoid (pigment) production, and design and development of contaminated water and soil bioremediation processes by means of microorganisms. This research has received competitive public grants from the European Commission, the Spanish Ministry of Economy and Competitiveness, the Valencia Region Government, and the University of Alicante.",institutionString:"University of Alicante",institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:45,paginationItems:[{id:"83122",title:"New Perspectives on the Application of Chito-Oligosaccharides Derived from Chitin and Chitosan: A Review",doi:"10.5772/intechopen.106501",signatures:"Paul Edgardo Regalado-Infante, Norma Gabriela Rojas-Avelizapa, Rosalía Núñez-Pastrana, Daniel Tapia-Maruri, Andrea Margarita Rivas-Castillo, Régulo Carlos Llarena-Hernández and Luz Irene Rojas-Avelizapa",slug:"new-perspectives-on-the-application-of-chito-oligosaccharides-derived-from-chitin-and-chitosan-a-rev",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chitin-Chitosan - Isolation, Properties, and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83015",title:"Acute Changes in Lipoprotein-Associated Oxidative Stress",doi:"10.5772/intechopen.106489",signatures:"Ngoc-Anh Le",slug:"acute-changes-in-lipoprotein-associated-oxidative-stress",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Anh",surname:"Le"}],book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"83041",title:"Responses of Endoplasmic Reticulum to Plant Stress",doi:"10.5772/intechopen.106590",signatures:"Vishwa Jyoti Baruah, Bhaswati Sarmah, Manny Saluja and Elizabeth H. Mahood",slug:"responses-of-endoplasmic-reticulum-to-plant-stress",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. 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He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"19",type:"subseries",title:"Animal Science",keywords:"Animal Science, Animal Biology, Wildlife Species, Domesticated Animals",scope:"The Animal Science topic welcomes research on captive and wildlife species, including domesticated animals. The research resented can consist of primary studies on various animal biology fields such as genetics, nutrition, behavior, welfare, and animal production, to name a few. 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