\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"4610",leadTitle:null,fullTitle:"Muscle Cell and Tissue",title:"Muscle Cell and Tissue",subtitle:null,reviewType:"peer-reviewed",abstract:"In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.",isbn:null,printIsbn:"978-953-51-2156-5",pdfIsbn:"978-953-51-4218-8",doi:"10.5772/59347",price:139,priceEur:155,priceUsd:179,slug:"muscle-cell-and-tissue",numberOfPages:486,isOpenForSubmission:!1,isInWos:1,isInBkci:!0,hash:"f2719cb06d2a1327298528772eacec55",bookSignature:"Kunihiro Sakuma",publishedDate:"September 2nd 2015",coverURL:"https://cdn.intechopen.com/books/images_new/4610.jpg",numberOfDownloads:33544,numberOfWosCitations:39,numberOfCrossrefCitations:21,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:53,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:113,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 1st 2014",dateEndSecondStepPublish:"October 22nd 2014",dateEndThirdStepPublish:"January 26th 2015",dateEndFourthStepPublish:"April 26th 2015",dateEndFifthStepPublish:"May 26th 2015",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,8,9",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"173502",title:"Dr.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/173502/images/system/173502.jpg",biography:"Associate professor Kunihiro Sakuma, Ph.D., currently works at the Research Center for Physical Fitness, Sports and Health in Toyohashi University of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded sports science diploma in 1995 by the University of Tsukuba and started scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later was turned to the molecular mechanism and the attenuating strategy of sarcopenia (age-related muscle atrophy). Preventing sarcopenia is important for maintaining a high quality of life in the aged population. His opinion is to attenuate sarcopenia by improving autophagic defect using nutrient- and pharmaceutical-based treatments.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Toyohashi University of Technology",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"980",title:"Tissue Engineering and Regenerative Medicine",slug:"tissue-engineering-and-regenerative-medicine"}],chapters:[{id:"48851",title:"Vascular Smooth Muscle as a Therapeutic Target in Disease Pathology",doi:"10.5772/60878",slug:"vascular-smooth-muscle-as-a-therapeutic-target-in-disease-pathology",totalDownloads:1742,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Our circulatory system is composed of numerous elements that are responsible for transport of blood and delivery of essential nutrients and gases to vital downstream tissues. Among these components that make up our circulation is vascular smooth muscle (VSM), the primary muscular and contractile element of blood vessels and regulator of many blood vessel functions. This is of particular importance as cardiovascular disease (CVD), the number one killer of individuals in America and worldwide, is primarily vascular in origin. Logically, identifying and characterizing feasible targets that could control CVD are highly appealing and much desired. With this in mind and given its centrality in control of vascular physiology, VSM has gained wide attention as a plausible target to combat elements of CVD. This book chapter focuses on VSM as a potential therapeutic target against CVD and will provide overview of vascular anatomy and physiology and brief discussions about the pivotal roles of VSM in CVD pathology, the influence of abnormal blood flow mechanics and hemodynamics in CVD, neural control of VSM and the vasculature, and possible novel cellular and molecular signaling targets that could be used to control and/or minimize CVD. This chapter hopes to serve as a valuable resource for basic and applied scientists as well as clinicians interested in understanding the crucial roles that VSM plays in vessel physiology and pathology.",signatures:"Andrew W. Holt and David A. Tulis",downloadPdfUrl:"/chapter/pdf-download/48851",previewPdfUrl:"/chapter/pdf-preview/48851",authors:[{id:"138308",title:"Prof.",name:"David",surname:"Tulis",slug:"david-tulis",fullName:"David Tulis"},{id:"173772",title:"Mr.",name:"Andrew",surname:"Holt",slug:"andrew-holt",fullName:"Andrew Holt"}],corrections:null},{id:"48338",title:"Vascular Wall-Resident Multipotent Stem Cells within the Process of Vascular Remodelling",doi:"10.5772/60561",slug:"vascular-wall-resident-multipotent-stem-cells-within-the-process-of-vascular-remodelling",totalDownloads:1838,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Processes of new vessel formation are central events in tissue development and repair. Therein, sprouting endothelial cells and/or endothelial progenitor cells form immature blood vessels that lack coverage by pericytes and other mural cells. Subsequently, vascular remodelling takes place, in which association with mural cells (pericytes and smooth muscle cells, SMC) stabilizes these immature vessels resulting in normalization of the vascular structures. Vascular remodelling is a dynamic and strictly regulated process; an ordered remodelling seems to be critical for proper vascular development, maintenance and stability of the vessel wall. The molecular and cellular changes associated with this process and its importance for tumour growth remain elusive. Up to now, the origin of vascular wall cells in tumours and the molecular mechanisms that govern their recruitment and association with angiogenic endothelial cells (vascular stabilization) are not well understood. There is some evidence that pericytes and SMC might originate from multipotent mesenchymal stem cells. This chapter aims to explore the role of tissue-resident multipotent stem cells of mesenchymal nature (VW-MPSCs) which putatively reside in the adventitia of adult blood vessels within the process of vascular remodelling of tumour blood vessels as well as of molecular factors that regulate VW-MPSC differentiation into pericytes and SMC.",signatures:"Diana Klein",downloadPdfUrl:"/chapter/pdf-download/48338",previewPdfUrl:"/chapter/pdf-preview/48338",authors:[{id:"173541",title:"Dr.",name:"Diana",surname:"Klein",slug:"diana-klein",fullName:"Diana Klein"}],corrections:null},{id:"48525",title:"Implications of MicroRNAs in the Vascular Homeostasis and Remodeling",doi:"10.5772/60740",slug:"implications-of-micrornas-in-the-vascular-homeostasis-and-remodeling",totalDownloads:1712,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Vascular remodeling or arterial remodeling is a process of adaptive alteration of vascular wall architecture and leads to the endothelial cell (EC) dysfunction and synthetic or contractile phenotypic change of VSMCs, and the infiltration of monocytes and Macrophages that promotes vascular diseases including atherosclerosis. Recent findings have demonstrated that microRNAs (miRNAs) are involved in regulating gene expression at posttranscriptional level and disease pathogenesis. A change of miRNA expression profiles plays key roles in the gene expressions and the regulation of cellular functions. In this chapter, we summarize the vascular remodeling-related miRNAs and their functions in vascular biology.",signatures:"Seahyoung Lee, Eunhyun Choi, Min-Ji Cha and Ki-Chul Hwang",downloadPdfUrl:"/chapter/pdf-download/48525",previewPdfUrl:"/chapter/pdf-preview/48525",authors:[{id:"173709",title:"Prof.",name:"Ki-Chul",surname:"Hwang",slug:"ki-chul-hwang",fullName:"Ki-Chul Hwang"},{id:"177754",title:"Dr.",name:"Seahyoung",surname:"Lee",slug:"seahyoung-lee",fullName:"Seahyoung Lee"},{id:"177755",title:"Dr.",name:"Eunhyun",surname:"Choi",slug:"eunhyun-choi",fullName:"Eunhyun Choi"},{id:"177756",title:"Dr.",name:"Min-Ji",surname:"Cha",slug:"min-ji-cha",fullName:"Min-Ji Cha"}],corrections:null},{id:"48770",title:"Lifestyle and Aging Effects in the Development of Insulin Resistance — Activating the Muscle as Strategy Against Insulin Resistance by Modulating Cytokines and HSP70",doi:"10.5772/60895",slug:"lifestyle-and-aging-effects-in-the-development-of-insulin-resistance-activating-the-muscle-as-strate",totalDownloads:2006,totalCrossrefCites:2,totalDimensionsCites:4,hasAltmetrics:1,abstract:"This chapter discusses about subclinical processes related to insulin resistance development that worsen the muscle metabolic functions, generated by factors such as lifestyle (bad quality food intake and sedentary behavior) and aging. Also discussed are the effects of regular physical exercise as a strategy to prevent the metabolic impairment in organisms, approaching since muscle subclinical molecular processes to the whole body’s integrative physiology. Insulin resistance development includes modification in the pattern of inflammatory cytokines, heat shock proteins, tissue- specific defects in insulin action and signaling, oxidative stress and ectopic lipid deposition. The exercise is a known modulator of all parameters listed above and has important role in the regulation of “immune-metabolic” homeostasis from the muscle to the whole body. This chapter aims to present a new molecular approach related to the control of metabolism and encourage scientists and students to propose new strategies against insulin resistance and diabetes type 2 developments.",signatures:"Thiago Gomes Heck, Mirna Stela Ludwig, Analu Bender dos Santos\nand Pauline Brendler Goettems-Fiorin",downloadPdfUrl:"/chapter/pdf-download/48770",previewPdfUrl:"/chapter/pdf-preview/48770",authors:[{id:"142388",title:"Dr.",name:"Thiago",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck"},{id:"155352",title:"Prof.",name:"Mirna",surname:"Stela Ludwig",slug:"mirna-stela-ludwig",fullName:"Mirna Stela Ludwig"},{id:"173960",title:"Prof.",name:"Pauline",surname:"Goettems-Fiorin",slug:"pauline-goettems-fiorin",fullName:"Pauline Goettems-Fiorin"},{id:"173961",title:"Dr.",name:"Analu",surname:"Bender Dos Santos",slug:"analu-bender-dos-santos",fullName:"Analu Bender Dos Santos"}],corrections:null},{id:"48386",title:"Importance of Plasma Membrane Nanodomains in Skeletal Muscle Regeneration",doi:"10.5772/60615",slug:"importance-of-plasma-membrane-nanodomains-in-skeletal-muscle-regeneration",totalDownloads:2562,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Numerous studies showed the importance of skeletal muscle plasma membrane (sarcolemma) in the control of skeletal muscle biology. The emphasis in this review is on the sarcolemmal bioactive lipids decisive for survival, proliferation, differentiation, and function of skeletal muscle cells with the particular concern on muscle stem cells (resident satellite cells, RSC) responsible for muscle regeneration. Nowadays, it is obvious that cholesterol (CHOL), basic component of the lipid rafts (LR) through the control of assembled dystrophin–glycoprotein complexes (DGC), directs muscle fiber contractile properties. Another phospholipid, phosphatidylserine (PS), is a component of the inner plasma membrane leaflet, even though it allows the fusion of myoblasts when exteriorized. Sphingolipids, such as ceramide, sphingosine, sphingosine-1-phosphate, and ganglioside GM3, are important signaling molecules in the charge of RSC activation, their motility, and commitment to particular lineage (myoblasts and myofibroblasts). Phosphoinositides and phosphatidylinositol-4,5-biphosphate (PIP2) specifically establish protoplasmic platforms for protein interactions essential for cell viability and mitochondrial activity. Additionally, both prenylation and palmitoylation of certain proteins (i.e., heterotrimeric G proteins) determine their biological activity in signal transduction from G-protein coupled receptors (GPCR). Isoprenoids are therefore crucial for the recruitment and metabolic responses of RSC to physiological and pathological stimuli. Finally, iatrogenic modifications of sarcolemma with hydroxylamines and their derivatives lead to increased resistance of muscle cells to apoptotic stimuli and slow progression of some skeletal muscle dystrophies.",signatures:"Beata Pająk and Arkadiusz Orzechowski",downloadPdfUrl:"/chapter/pdf-download/48386",previewPdfUrl:"/chapter/pdf-preview/48386",authors:[{id:"173522",title:"Prof.",name:"Arkadiusz",surname:"Orzechowski",slug:"arkadiusz-orzechowski",fullName:"Arkadiusz Orzechowski"},{id:"173528",title:"Dr.",name:"Beata",surname:"Pająk",slug:"beata-pajak",fullName:"Beata Pająk"}],corrections:null},{id:"48820",title:"Molecular Mechanisms Controlling Skeletal Muscle Mass",doi:"10.5772/60876",slug:"molecular-mechanisms-controlling-skeletal-muscle-mass",totalDownloads:2351,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"The interplay between multiple signaling pathways regulates the maintenance of skeletal muscle. Under physiological conditions, a network of interconnected signals serves to coordinate hypertrophic and atrophic inputs, culminating in a delicate balance between muscle protein synthesis and proteolysis. Loss of skeletal muscle mass, termed “atrophy,” is a diagnostic feature of cachexia such as cancer, heart disease, and chronic obstructive pulmonary disease. Recent studies have further defined the pathways leading to gain and loss of skeletal muscle as well as the signaling events that induce post-injury regeneration. In this review, we summarize the relevant recent literature demonstrating these previously undiscovered mediators governing anabolism and catabolism of skeletal muscle.",signatures:"Kunihiro Sakuma and Akihiko Yamaguchi",downloadPdfUrl:"/chapter/pdf-download/48820",previewPdfUrl:"/chapter/pdf-preview/48820",authors:[{id:"173502",title:"Dr.",name:"Kunihiro",surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma"},{id:"177757",title:"Dr.",name:"Akihiko",surname:"Yamaguchi",slug:"akihiko-yamaguchi",fullName:"Akihiko Yamaguchi"}],corrections:null},{id:"48511",title:"Autophagy, a Highly Regulated Intracellular System Essential to Skeletal Muscle Homeostasis — Role in Disease, Exercise and Altitude Exposure",doi:"10.5772/60698",slug:"autophagy-a-highly-regulated-intracellular-system-essential-to-skeletal-muscle-homeostasis-role-in-d",totalDownloads:2305,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Autophagy is an evolutionarily conserved intracellular system that selectively eliminates protein aggregates, damaged organelles, and other cellular debris. It is a self-cleaning process critical for cell homeostasis in conditions of energy stress. Autophagy has been until now relatively overlooked in skeletal muscle, but recent data highlight its vital role in this tissue in response to several stress conditions. The most recognized sensors for autophagy modulation are the adenosine monophosphate (AMP)-activated protein kinase (AMPK) and the mechanistic target of rapamycin (MTOR). AMPK acts as a sensor of cellular energy status by regulating several intracellular systems including glucose and lipid metabolisms and mitochondrial biogenesis. Recently, AMPK has been involved in the control of protein synthesis by decreasing MTOR activity and in the control of protein breakdown programs. Concerning proteolysis, AMPK notably regulates autophagy through FoxO transcription factors and Ulk1 complex. In this chapter, we describe the functioning of the different autophagy pathways (macroautophagy, microautophagy, and chaperone-mediated autophagy) in skeletal muscle and define the role of macroautophagy in response to physical exercise, a stress that is well assumed to be a key strategy to counteract metabolic and muscle diseases. The effects of dietary factors and altitude exposure are also discussed in the context of exercise.",signatures:"Anthony M.J. Sanchez, Robin Candau, Audrey Raibon and Henri\nBernardi",downloadPdfUrl:"/chapter/pdf-download/48511",previewPdfUrl:"/chapter/pdf-preview/48511",authors:[{id:"173735",title:"Dr.",name:"Henri",surname:"Bernardi",slug:"henri-bernardi",fullName:"Henri Bernardi"},{id:"175602",title:"Prof.",name:"Robin",surname:"Candau",slug:"robin-candau",fullName:"Robin Candau"},{id:"175603",title:"Dr.",name:"Audrey",surname:"Raibon",slug:"audrey-raibon",fullName:"Audrey Raibon"},{id:"175604",title:"Dr.",name:"Anthony Mj",surname:"Sanchez",slug:"anthony-mj-sanchez",fullName:"Anthony Mj Sanchez"}],corrections:null},{id:"48493",title:"Cell Composition of the Subendothelial Aortic Intima and the Role of Alpha-Smooth Muscle Actin Expressing Pericyte-Like Cells and Smooth Muscle Cells in the Development of Atherosclerosis",doi:"10.5772/60430",slug:"cell-composition-of-the-subendothelial-aortic-intima-and-the-role-of-alpha-smooth-muscle-actin-expre",totalDownloads:1653,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The cell composition of the human arterial intima has been intensely studied but is still not well understood. The majority of cell population in normal and atherosclerotic intima is represented by cells expressing smooth muscle α-actin, which are thought to be smooth muscle cells. Some antigens, which are absent in medial smooth muscle cells, were detected in intimal smooth muscle cells. In particular, using 3G5 antipericyte antibody, presence of stellate-shaped pericyte-like resident cells in normal and atherosclerotic human aortic intima has been found. In all analyzed aortic tissue specimens, 3G5+ cells were found to account for more than 30% of the total intimal cell population of undiseased intima. In the atherosclerotic lesions, the number of 3G5+ cells becomes notably lower than that in undiseased intima. The use of 2A7 antibody that identifies activated pericytes revealed the presence of 2A7+ cells in atherosclerotic plaques, while no 2A7+ cells were detected in normal intima. The strongest correlation was established between the number of pericyte-like cells and the content of intimal lipids. The correlation coefficients between the number of pericyte-like cells and collagen content and intimal thickness were greater than the correlation coefficients for smooth muscle cells. On the basis of these findings, pericyte-like cells but not smooth muscle cells or other cell types have been declared to be the key cellular element driving the formation of atherosclerotic lesions. The present chapter aims to detail the abovementioned issues. The present chapter also aims to promote a view that α-smooth muscle actin+ pericyte-like cells represent the key players in the development of atherosclerotic lesions.",signatures:"Alexander N. Orekhov and Yuri V. Bobryshev",downloadPdfUrl:"/chapter/pdf-download/48493",previewPdfUrl:"/chapter/pdf-preview/48493",authors:[{id:"159026",title:"Prof.",name:"Alexander",surname:"Orekhov",slug:"alexander-orekhov",fullName:"Alexander Orekhov"},{id:"173729",title:"Dr.",name:"Yuri",surname:"Bobryshev",slug:"yuri-bobryshev",fullName:"Yuri Bobryshev"}],corrections:null},{id:"48724",title:"Dynamic Interplay Between Smooth Muscle Cells and Macrophages in Vascular Disease",doi:"10.5772/61089",slug:"dynamic-interplay-between-smooth-muscle-cells-and-macrophages-in-vascular-disease",totalDownloads:2133,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Vascular smooth muscle cells (SMCs) and monocytes/macrophages represent major players in atherosclerotic vascular diseases. In addition to physiological and pathological roles of each cell type in atherosclerosis, dynamic interplay between SMCs and monocytes/macrophages may contribute to the pathogenesis of atherosclerosis more critically than previously understood. Activated macrophages accelerate pro-atherogenic functions of SMCs in vascular lesions. Activated SMCs promote additional accumulation of pro-inflammatory macrophages through expression of chemoattractants. More recent evidence suggests the interchangeability between SMC and monocyte/macrophage lineages. Future efforts to understand such dynamic interactions between SMCs and macrophages may provide novel insight into the pathogenesis of vascular disease and the development of new classes of medical solutions.",signatures:"Hiroshi Iwata and Masanori Aikawa",downloadPdfUrl:"/chapter/pdf-download/48724",previewPdfUrl:"/chapter/pdf-preview/48724",authors:[{id:"48818",title:"Dr.",name:"Hiroshi",surname:"Iwata",slug:"hiroshi-iwata",fullName:"Hiroshi Iwata"},{id:"164342",title:"Dr.",name:"Masanori",surname:"Aikawa",slug:"masanori-aikawa",fullName:"Masanori Aikawa"}],corrections:null},{id:"48576",title:"Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes",doi:"10.5772/60714",slug:"current-challenges-in-understanding-the-story-of-skin-pigmentation-bridging-the-morpho-anatomical-an",totalDownloads:2630,totalCrossrefCites:2,totalDimensionsCites:13,hasAltmetrics:1,abstract:"Melanocytes are specialized dendritic melanin producing pigment cells, which have originated from the pluripotent embryonic cells and are termed as neural crest cells (NCC). The primary locations of these cells are basal layer of epidermis and hair follicles. Besides this, they are also found in the inner ear, nervous system, and heart with spatial specific functions. There are other cells able to produce melanin but of different embryonic origin (pigmented epithelium of retina, some neurons, and adipocytes). Melanocytes of the epidermis and hair are cells which share some common structural features but in general they form biologically different populations living in unique niches of the skin. Ultra structurally, melanocytes differ from each other on the basis of their locations and function. Principal function of epidermal melanocytes is photoprotection and thermoregulation by packaging melanin pigment into melanosomes and delivering them to neighboring keratinocytes. It is unfair to think that melanocytes reap all the glory for their role in pigmenting the skin and providing it critical protection against UV damage. They probably play a significant role in diverse physiological functions and their particular functions in all target places are much wider than the melanin synthesis only. Alternation in any structure and function of these pigmentary cells affects the process of pigmentation/melanogenesis which leads to pigmentary disorders like hyperpigmentation or hypopigmentation.",signatures:"Sharique A. Ali and Ishrat Naaz",downloadPdfUrl:"/chapter/pdf-download/48576",previewPdfUrl:"/chapter/pdf-preview/48576",authors:[{id:"141203",title:"Dr.",name:"Sharique A.",surname:"Ali",slug:"sharique-a.-ali",fullName:"Sharique A. Ali"},{id:"174823",title:"Ms.",name:"Ishrat",surname:"Naaz",slug:"ishrat-naaz",fullName:"Ishrat Naaz"}],corrections:null},{id:"48855",title:"Ca2+ Dynamics and Ca2+ Sensitization in the Regulation of Airway Smooth Muscle Tone",doi:"10.5772/60969",slug:"ca2-dynamics-and-ca2-sensitization-in-the-regulation-of-airway-smooth-muscle-tone",totalDownloads:2525,totalCrossrefCites:2,totalDimensionsCites:7,hasAltmetrics:0,abstract:"Airway smooth muscle tone is ultimately generated by phosphorylation of myosin light chain, which is regulated by the balance between concentrations of Ca2+ and sensitivity to Ca2+ in the cytosolic side. The former is due to the Ca2+ influx passing through ion channels (Ca2+ dynamics), leading to activation of myosin light chain kinase, and the latter is due to Rho-kinase (Ca2+ sensitization), leading to the inactivation of myosin phosphatase. Alterations to contractility and to the proliferative phenotype, which are influenced by Ca2+ dynamics and Ca2+ sensitization, are involved in the pathophysiology of asthma and chronic obstructive pulmonary disease (COPD). Ca2+ dynamics are mainly due to store-operated capacitative Ca2+ influx and receptor-operated Ca2+ influx, and partly due to L-type voltage-dependent Ca2+ (VDC) channels. Large-conductance Ca2+-activated K+ (KCa, BKCa, Maxi-K+) channels are activated by Gs connected to β2-adrenoceptors, whereas these channels are inhibited by Gi connected to M2 muscarinic receptors. VDC channel activity regulated by KCa channels contributes to not only functional antagonism between β2-adrenoceptors and muscarinic receptors but also to synergistic effects between β2-adrenoceptor agonists and muscarinic receptor antagonists. Moreover, an increase in Ca2+ influx via the KCa/VDC channel linkage causes airflow limitation and β2-adrenergic desensitization. In contrast, an increase in sensitivity to Ca2+ via Rho-kinase causes airflow limitation, airway hyperresponsiveness, β2-adrenergic desensitization, and airway remodeling. These airway disorders are characteristic features of asthma and COPD. KCa channels are regulated by trimeric G proteins (Gs, Gi), and Rho-kinase is regulated by a monomeric G protein (RhoA). Therefore, Ca2+ dynamics due to G proteins/KCa/VDC channel linkage and Ca2+ sensitization due to RhoA/Rho-kinase processes are therapeutic targets for these diseases.",signatures:"Hiroaki Kume",downloadPdfUrl:"/chapter/pdf-download/48855",previewPdfUrl:"/chapter/pdf-preview/48855",authors:[{id:"173510",title:"Prof.",name:"Hiroaki",surname:"Kume",slug:"hiroaki-kume",fullName:"Hiroaki Kume"}],corrections:null},{id:"48787",title:"Research on Skeletal Muscle Diseases Using Pluripotent Stem Cells",doi:"10.5772/60902",slug:"research-on-skeletal-muscle-diseases-using-pluripotent-stem-cells",totalDownloads:1680,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The generation of induced pluripotent stem cells (iPSCs), especially the generation of patient-derived pluripotent stem cells (PSCs) suitable for disease modelling in vitro, opens the door for the potential translation of stem-cell related studies into the clinic. Successful replacement, or augmentation, of the function of damaged cells by patient-derived differentiated stem cells would provide a novel cell-based therapy for skeletal muscle-related diseases. Since iPSCs resemble human embryonic stem cells (hESCs) in their ability to generate cells of the three germ layers, patient-specific iPSCs offer definitive solutions for the ethical and histo-incompatibility issues related to hESCs. Indeed human iPSC (hiPSC)-based autologous transplantation is heralded as the future of regenerative medicine. Interestingly, during the last years intense research has been published on disease-specific hiPSCs derivation and differentiation into relevant tissues/organs providing a unique scenario for modelling disease progression, to screen patient-specific drugs and enabling immunosupression-free cell replacement therapies. Here, we revise the most relevant findings in skeletal muscle differentiation using mouse and human PSCs. Finally and in an effort to bring iPSC technology to the daily routine of the laboratory, we provide two different protocols for the generation of patient-derived iPSCs.",signatures:"Lorena de Oñate, Elena Garreta, Carolina Tarantino, Elena Martínez,\nEncarnación Capilla, Isabel Navarro, Joaquín Gutiérrez, Josep\nSamitier, Josep Maria Campistol, Pura Muñoz-Cánovas and Nuria\nMontserrat",downloadPdfUrl:"/chapter/pdf-download/48787",previewPdfUrl:"/chapter/pdf-preview/48787",authors:[{id:"170057",title:"Dr.",name:"Encarnación",surname:"Capilla",slug:"encarnacion-capilla",fullName:"Encarnación Capilla"},{id:"173781",title:"Ph.D.",name:"Nuria",surname:"Montserrat",slug:"nuria-montserrat",fullName:"Nuria Montserrat"},{id:"173946",title:"Prof.",name:"Joaquin",surname:"Gutiérrez",slug:"joaquin-gutierrez",fullName:"Joaquin Gutiérrez"},{id:"173947",title:"Prof.",name:"Isabel",surname:"Navarro",slug:"isabel-navarro",fullName:"Isabel Navarro"},{id:"173948",title:"Dr.",name:"Elena",surname:"Garreta",slug:"elena-garreta",fullName:"Elena Garreta"},{id:"173949",title:"Dr.",name:"Elena",surname:"Martínez",slug:"elena-martinez",fullName:"Elena Martínez"},{id:"173950",title:"Prof.",name:"Pura",surname:"Muñoz",slug:"pura-munoz",fullName:"Pura Muñoz"},{id:"173951",title:"BSc.",name:"Lorena",surname:"De Oñate",slug:"lorena-de-onate",fullName:"Lorena De Oñate"}],corrections:null},{id:"48727",title:"Smooth Muscle and Extracellular Matrix Interactions in Health and Disease",doi:"10.5772/60403",slug:"smooth-muscle-and-extracellular-matrix-interactions-in-health-and-disease",totalDownloads:2156,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Alterations in smooth muscle cell function and phenotype contribute to tissue remodeling in various pathologies including obstructive lung (e.g., asthma) and vascular (e.g., atherosclerosis) diseases. The extracellular matrix (ECM) is a major influence on the biology of smooth muscle cells, being an important support structure that provides signaling cues through its biochemical and biophysical properties. ECM factors activate biochemical and mechano-transduction signaling pathways, which modulate smooth muscle cell contraction, stiffness, survival, growth, cytokine production and migration (i.e., cellular processes which contribute to changes in tissue architecture). The interaction of the ECM with smooth muscle cells is a dynamic multi-directional process, as smooth muscle cells also produce ECM protein, as well as proteases and cross-linking enzymes which regulate ECM form and structure. Understanding the molecular basis of ECM modifications and their impact on smooth muscle cell function in disease may lead to the development of novel therapies. This chapter reviews interactions between the ECM and smooth muscle cell and how they become altered in disease, using obstructive lung and vascular diseases as examples. From a pharmacological and therapeutic perspective, strategies that alter the phenotype of the smooth muscle cell in disease will be discussed. Emphasis will be given to approaches that target the proteases and mediators of ECM-smooth muscle cell signaling as potential treatments for pulmonary and vascular disease. Proteases of the coagulation and plasminogen activation systems have been given particular attention as they not only have a role in forming and modifying ECM, but also can directly stimulate changes in smooth muscle cell function and phenotype via activating receptors such as the protease-activated receptor-1 (PAR-1) and integrins.",signatures:"Michael Schuliga",downloadPdfUrl:"/chapter/pdf-download/48727",previewPdfUrl:"/chapter/pdf-preview/48727",authors:[{id:"173789",title:"Dr.",name:"Michael",surname:"Schuliga",slug:"michael-schuliga",fullName:"Michael Schuliga"}],corrections:null},{id:"48782",title:"Novel Therapeutic Approaches for Skeletal Muscle Dystrophies",doi:"10.5772/60479",slug:"novel-therapeutic-approaches-for-skeletal-muscle-dystrophies",totalDownloads:1640,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Muscular dystrophies (MDs) are inherited diseases that affect skeletal and cardiac muscle tissues. Cases range from mild to very severe, resulting in respiratory or cardiac failures. No cures are available for MDs and corticosteroid treatments, mainly deflazacort and prednisolone, only help to control the inflammatory process and slightly delay the progression of the disease. This is due to the beneficial effect on pulmonary function and scoliosis. Walkers and wheelchairs are used to strengthen patients’ independence and walking ability. When respiratory and/or cardiac muscles become weak, mechanical ventilation is mandatory. In addition, hypertension, cataracts, excessive weight gain and vertebral fracture are often serious side effects of deflazacort and prednisolone treatments.",signatures:"Emanuele Berardi and Maurilio Sampaolesi",downloadPdfUrl:"/chapter/pdf-download/48782",previewPdfUrl:"/chapter/pdf-preview/48782",authors:[{id:"87287",title:"Prof.",name:"Maurilio",surname:"Sampaolesi",slug:"maurilio-sampaolesi",fullName:"Maurilio Sampaolesi"}],corrections:null},{id:"48842",title:"Use of Biomaterials and Biomolecules for the Prevention of Restenosis",doi:"10.5772/61081",slug:"use-of-biomaterials-and-biomolecules-for-the-prevention-of-restenosis",totalDownloads:1651,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Coronary balloon angioplasty and coronary stenting are the procedures used in healing coronary artery disease. However, injury of arteries during angioplasty and stenting causes cell stimulations in tissue. Cell movement and thrombosis lead to re-narrowing of widened vessel called restenosis. Several new types of carriers and technology have been developed to suppress and/or prevent restenosis via prevention of migration/proliferation of smooth muscle cells (SMCs). The conventional approaches are not fully effective for inhibiting restenosis. In order to eliminate such problems, stent-based delivery methods are developed to replace traditional vascular approaches. A series of materials have been improved for controlled delivery/release of genes, miRNAs, peptide structures, siRNAs, miRNAs, and antisense molecules to the target tissue. Agents to be delivered are either attached to the materials or entrapped in polymeric structure. In particular, biodegradable polymers have held great interests in drug delivery for targeting or prolonging implantable drug release. This chapter summarizes the molecular mechanisms of in-stent restenosis, the role of SMCs and endothelial cells in restenosis, and recent researches about the polymeric materials featured in drug/gene carrier systems, nanovehicles, and stent coating materials to prevent restenosis.",signatures:"Nelisa Türkoğlu Laçin, Kadriye Kızılbey and Banu Mansuroğlu",downloadPdfUrl:"/chapter/pdf-download/48842",previewPdfUrl:"/chapter/pdf-preview/48842",authors:[{id:"173575",title:"Dr.",name:"Nelisa",surname:"Laçin",slug:"nelisa-lacin",fullName:"Nelisa Laçin"}],corrections:null},{id:"48942",title:"Three-Dimensional “Honeycomb” Culture System that Helps to Maintain the Contractile Phenotype of Vascular Smooth Muscle Cells",doi:"10.5772/60960",slug:"three-dimensional-honeycomb-culture-system-that-helps-to-maintain-the-contractile-phenotype-of-vascu",totalDownloads:1516,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Vascular smooth muscle cells (VSMCs) in the normal aorta are described as having a contractile phenotype because they can contract and do not proliferate. VSMCs in pathological conditions such as atherosclerosis and restenosis can proliferate and migrate, but lose their ability to contract, which is referred to as a synthetic phenotype. VSMCs show plasticity by changing their phenotype according to the surrounding environment. When VSMCs are cultured on a plastic plate, which is a normal two-dimensional culture system, they display the synthetic phenotype because they proliferate and migrate without contraction. Recently, we successfully cultured VSMCs that display features similar to the contractile phenotype, using type I collagen three-dimensional matrices, “honeycombs,” in the presence of abundant fetal bovine serum albumin. VSMCs cultured in honeycombs stop proliferating and can contract. The honeycomb culture system can maintain VSMCs in the contractile phenotype for a long period of time. In this chapter, we show the method of this new culture system and the characteristics of VSMCs in honeycombs. It is expected that the use of this culture system will generate new information on the characteristics of VSMCs.",signatures:"Itsuko Ishii and Masashi Uchida",downloadPdfUrl:"/chapter/pdf-download/48942",previewPdfUrl:"/chapter/pdf-preview/48942",authors:[{id:"173711",title:"Prof.",name:"Itsuko",surname:"Ishii",slug:"itsuko-ishii",fullName:"Itsuko Ishii"}],corrections:null},{id:"48557",title:"Role of Platelet-Activating Factor and Hypoxia in Persistent Pulmonary Hypertension of the Newborn — Studies with Perinatal Pulmonary Vascular Smooth Muscle Cells",doi:"10.5772/60728",slug:"role-of-platelet-activating-factor-and-hypoxia-in-persistent-pulmonary-hypertension-of-the-newborn-s",totalDownloads:1444,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Platelet-activating factor (PAF) plays an important physiological role of maintaining a high vasomotor tone in fetal pulmonary circulation. At birth, endogenous vasodilators such as nitric oxide and prostacyclin are released and facilitate pulmonary vasodilation via cAMP-dependent protein kinase (cAMP/PKA) and cGMP-dependent protein kinase (cGMP/PKG) pathways. Interaction between the cyclic nucleotides and PAF receptor (PAFR)-mediated responses in pulmonary arterial smooth muscle is not well understood. To further understand the interactions of PAF-PAFR pathway and the cyclic nucleotides in ovine fetal pulmonary arterial smooth muscle cells (FPASMC), effects of cAMP and cGMP on PAFR-mediated responses in pulmonary arterial smooth muscle cells (PASMC) were studied. Ovine FPASMC were incubated with 10μM cAMP or cGMP in normoxia (5% CO2 in air, pO2~100 Torr) or hypoxia (2% O2, 5% CO2, pO2~30-40 Torr). Proteins were prepared and subjected to Western blotting. Effect of cell permeable cAMP and cGMP on PAFR binding was also studied and effect of cAMP on cell proliferation was also studied by RNAi to PKA-Cα. cAMP and cGMP significantly decreased PAFR binding and protein expression in normoxia and hypoxia, more so in hypoxia, when PAFR expression was usually high. PKA-Cα siRNA demonstrated that inhibition of PAFR-mediated responses by the cyclic nucleotides occurred through PKA. These data suggest that the normally high levels of cyclic nucleotides in the normoxic newborn pulmonary circulation assist in the downregulation of postnatal PAFR-mediated responses and that under hypoxic conditions, increasing the levels of cyclic nucleotides will abrogate PAF-mediated vasoconstriction thereby ameliorating PAF-induced persistent pulmonary hypertension of the newborn.",signatures:"Mona Hanouni, Amy M. McPeak, Stephen M. Douglass, Rebecca\nDavis, Shaemion McBride and Basil O. Ibe",downloadPdfUrl:"/chapter/pdf-download/48557",previewPdfUrl:"/chapter/pdf-preview/48557",authors:[{id:"173958",title:"Prof.",name:"Basil",surname:"Ibe",slug:"basil-ibe",fullName:"Basil Ibe"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3348",title:"Tissue Engineering",subtitle:null,isOpenForSubmission:!1,hash:"39bb39271df3b373edb7d5e2cdeffb18",slug:"tissue-engineering",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/3348.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3361",title:"Regenerative Medicine and Tissue Engineering",subtitle:null,isOpenForSubmission:!1,hash:"fe914d49a96b3dcd00d27292ae23536e",slug:"regenerative-medicine-and-tissue-engineering",bookSignature:"Jose A. 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An Overview of PET Radiopharmaceuticals in Clinical Use: Regulatory, Quality and Pharmacopeia Monographs of the United States and Europe",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/66068.pdf",downloadPdfUrl:"/chapter/pdf-download/66068",previewPdfUrl:"/chapter/pdf-preview/66068",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/66068",risUrl:"/chapter/ris/66068",chapter:{id:"62269",slug:"an-overview-of-pet-radiopharmaceuticals-in-clinical-use-regulatory-quality-and-pharmacopeia-monograp",signatures:"Ya-Yao Huang",dateSubmitted:"February 25th 2018",dateReviewed:"May 31st 2018",datePrePublished:"November 5th 2018",datePublished:"July 24th 2019",book:{id:"7373",title:"Nuclear Medicine Physics",subtitle:null,fullTitle:"Nuclear Medicine Physics",slug:"nuclear-medicine-physics",publishedDate:"July 24th 2019",bookSignature:"Aamir Shahzad and Sajid Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/7373.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"288354",title:"Dr.",name:"Aamir",middleName:null,surname:"Shahzad",slug:"aamir-shahzad",fullName:"Aamir Shahzad"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"247754",title:"Prof.",name:"Ya-Yao",middleName:null,surname:"Huang",fullName:"Ya-Yao Huang",slug:"ya-yao-huang",email:"careyyh@ntuh.gov.tw",position:null,institution:{name:"National Taiwan University Hospital",institutionURL:null,country:{name:"Taiwan"}}}]}},chapter:{id:"62269",slug:"an-overview-of-pet-radiopharmaceuticals-in-clinical-use-regulatory-quality-and-pharmacopeia-monograp",signatures:"Ya-Yao Huang",dateSubmitted:"February 25th 2018",dateReviewed:"May 31st 2018",datePrePublished:"November 5th 2018",datePublished:"July 24th 2019",book:{id:"7373",title:"Nuclear Medicine Physics",subtitle:null,fullTitle:"Nuclear Medicine Physics",slug:"nuclear-medicine-physics",publishedDate:"July 24th 2019",bookSignature:"Aamir Shahzad and Sajid Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/7373.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"288354",title:"Dr.",name:"Aamir",middleName:null,surname:"Shahzad",slug:"aamir-shahzad",fullName:"Aamir Shahzad"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"247754",title:"Prof.",name:"Ya-Yao",middleName:null,surname:"Huang",fullName:"Ya-Yao Huang",slug:"ya-yao-huang",email:"careyyh@ntuh.gov.tw",position:null,institution:{name:"National Taiwan University Hospital",institutionURL:null,country:{name:"Taiwan"}}}]},book:{id:"7373",title:"Nuclear Medicine Physics",subtitle:null,fullTitle:"Nuclear Medicine Physics",slug:"nuclear-medicine-physics",publishedDate:"July 24th 2019",bookSignature:"Aamir Shahzad and Sajid Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/7373.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"288354",title:"Dr.",name:"Aamir",middleName:null,surname:"Shahzad",slug:"aamir-shahzad",fullName:"Aamir Shahzad"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11670",leadTitle:null,title:"Chitin-Chitosan - Isolation, Properties, and Applications",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tCurrently, numerous biomaterials-based studies are being conducted, including research into chitin and chitosan, the second most abundant polysaccharide after cellulose. Chitin is obtained at an industrial scale from a variety of natural sources including, crustacean and insect exoskeletons, fungi cell walls, squid pen, etc. Chitosan is biodegradable, biocompatible, non-toxic, water-soluble under acidic conditions, and linear cationic amino polysaccharide derived from the deacetylation of chitin. It contains free amino and hydroxyl groups that can be functionalized by binding with the cationic and anionic groups. It has numerous applications, especially in the environmental remediation, biomedical, pharmaceutical, agriculture, and food industries.
\r\n\r\n\tThis book will present an update of articles addressing isolation, properties, and certain applications of chitin and chitosan, including films, fibers, nanoparticles, composite materials, hydrogels, polymeric complexes, water purification, antimicrobials, textile, cosmetics, biosensors, nanoporous scaffolds, and membranes. We invite world-class researchers from around the world, industry, academia, government, and private research institutions are encouraged to publish research or review articles on chitin and chitosan.
",isbn:"978-1-80356-693-1",printIsbn:"978-1-80356-692-4",pdfIsbn:"978-1-80356-694-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"69f009be08998711eecfb200adc7deca",bookSignature:"Dr. Brajesh Kumar",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11670.jpg",keywords:"Solvent, Acidic, Microwave, Binding, Biodegradable, Biocompatible, FTIR, NMR, XRD, Fibers, Nanoparticles, Composite Materials",numberOfDownloads:0,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 23rd 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Brajesh Kumar is a pioneering researcher in nanoscience and green chemistry. He is a member of the American Chemical Society, Indian Society of Chemists and Biologists, Indian Science Congress Association, Dr. Kumar, and holder of two registered patents. Dr. Kumar is also included in the top 2% of the scientist list prepared by experts at Stanford University, USA.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"176093",title:"Dr.",name:"Brajesh",middleName:null,surname:"Kumar",slug:"brajesh-kumar",fullName:"Brajesh Kumar",profilePictureURL:"https://mts.intechopen.com/storage/users/176093/images/system/176093.JPG",biography:"Dr. Brajesh Kumar is currently working as an Assistant Professor and Head in the Post Graduate Department of Chemistry, TATA College, Chaibasa, India. He received a Ph.D. in Chemistry from the University of Delhi, India. His research interest is in the development of sustainable and eco-friendly techniques for (a) nanoparticles synthesis and their applications for environmental remediation, (b) active films of organic solar cells, (c) nanomedicine, (d) sensors, (e) natural product extraction, purification, and analysis,(f) natural polymers, (g) peptide chemistry, (h) microwave and ultrasound-assisted organic synthesis and (i) organic synthesis. Dr. Brajesh Kumar has been credited for different national and international fellowships and he has also worked as a faculty member in various universities of India, Ecuador, and South Korea. He has also published numerous SCI/ SCIE/ Scopus research articles (h index = 29, Citations 2917) and is also an active reviewer of more than 50 Journals. 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What is it?
How does this impact us in different areas of our lives?
How can we encourage the development of healthy emotional regulation?
How do we know when we have gotten it right!?
We also want to encourage others to explore:
What happens when difficulties with emotional regulation emerge?
How do we re-regulate the body and mind?
Hopefully this chapter will answer these questions providing you with an overview of what is involved in the process of emotional regulation – so let us get started!
Emotional regulation is a phrase that doctors, psychologists, and even teachers and parents are using more and more. However even though it is something that everyone is talking about, lots of people are confused in regard to what emotional regulation actually is.
From our perspective, emotional regulation is all about recognising, understanding, influencing, controlling and experiencing and expressing emotions. Researchers such as Fresco, Mennin, Heimberg and Ritter [1] have carried out research to the same effect, defining emotional regulation in a similar way. Other researchers have explained that emotional regulation can at times be unconscious, or conscious. That means that sometimes we are aware of what we are feeling, and sometimes we are not. Oftentimes, we can influence which emotions we have, when we have them, to what degree they are felt and how they are expressed [2]. However, sometimes we lose control of our emotions and we become what scientists call “dysregulated”. When this happens, individuals are typically less able to understand, influence and control their emotions.
Emotions in themselves indicate how we feel about what is going on around us. They have a functional purpose; to notify us to the relevance of our concerns, to highlight to us what we consider to be important, what our needs and wants are in a given moment, and to help us navigate the world. Emotions exist on a spectrum for everyone; we all feel certain emotions to varying degrees, at different times. In other words, we can have a little or a lot of an emotion at any given time. The importance of developing an ability to internally regulate our emotional state has been well documented in scientific research. Emotional regulation is not just the process of acknowledging our feelings, but also understanding them to control them. This process of feeling, understanding and controlling our emotional state involves both the body and the mind, the physical state and our thought processes. Once an individual develops an understanding of what they are feelings, what thoughts they have and the possible triggers for these thoughts the feelings, then they can begin the process of self-regulation; the ability to regulate oneself and alter one’s own responses [2]. There is a positive relationship between how competent a person is regulating their emotional state, and how well they can adapt to both minor and major events in life. Those who are able to successfully tune into how they are feeling have a better change in being able to calm themselves down. Similarly, when a person understands the triggers for a particular emotion, then they will be better able to respond in a helpful manner. Let us look at this in a real life example.
A woman walks down the road, let us call her Alice. Alice sees a large dog coming towards her and she begins to feel anxiety and panic setting in. She feels her heart rate increase and the blood rush to her face. She thinks “I’m feeling anxious because I was bitten by a dog last year on holidays, it is still affecting me”. Alice is able to rationalise her feelings in this moment. She successfully identifies how she is feeling and she links this feeling to a triggering experience. Alice them tells herself “That dog on holidays was an angry dog, and it was unusual that he bit a stranger. The dog in front of me now looks kind, and he is out walking on a lead with its owner. It’s unlikely that he is going to bite me”. Alice takes several deep breaths and says to herself over and over again “I’m going to be okay, just keep walking”. Alice uses deep breathing to control her feelings of anxiety, thus linking her body and her mind. Her heartbeat drops, and she responds in a way which is helpful – she passes the dog. This demonstrates the process of recognising, understanding, influencing, controlling, experiencing and expressing emotions. Alice successfully engaged in emotional regulation – going through each stage of the process.
On the other hand, unhealthy emotional regulation patterns also exist. Unfortunately, when unhealthy emotional regulation develops – sometimes called dysregulation, it can negatively impact a person. It can impact how people interact with others, how they connect with others on a deep or intimate level, and it can also impact performance at work or other areas in a person’s life. In other words, the ability to regulate your own emotions is crucial to having effective and flexible responses, which influences how you deal with challenging situations in life [3].
Another concept in the area of emotional regulation is the idea of emotional complexity i.e. the co-occurrence of both positive and negative emotions simultaneously in the one individual [4]. This makes the topic of emotional regulation even more interesting (and complicated!) because people can have conflicting emotional states at the same time. People often have an easy time separating the good from the bad to divide them up, when actually they can exist together. For example, you could have a long-term relationship with someone who cares about you greatly; you have a nice time together, you have great memories and you have come to live together in a comfortable and safe home. But, this person also drove your car to work one morning and left a dent on the side of it. Healthy emotional regulation would look like someone who realises: it was probably a mistake, it is easily fixed and I do not believe that they meant to do it. Unhealthy patterns of emotional regulation now see this person as an inconvenience, that they care less about you and your belongings and that they do not care about stressing you out. Unhealthy patterns of emotional regulation can lead us to put certain things on pedestals and not others – without every questioning it. The reality is, good people can sometimes do “bad” things, and bad people may also sometimes do “good” things.
Emotional intensity also plays a role in the evaluation of one’s ability to regulate themselves. The intensity of your emotions relates to how you perceive your own emotions. Do not forget – the consequence must match the crime. Poor emotional regulation will have you feeling overly stressed about minor things, viewing small blips as massive problems and internalising stressful situations as more tiresome and threatening than they actually are. That’s the thing about seeing things as they “actually are” – the lens which will we look at life through is very much based on what we believe to be true, as conscious and independently thinking as human beings are, we do not always challenge these thoughts i.e. not all of your thoughts are true! Of course, at times, emotional intensity can be helpful to us; it gives us information about how we really feel about certain things. For example, if you felt more intense sadness at the passing of someone close to you, it is likely that you care deeply about this person and perhaps love them. Intense feelings give us a lot of information and it is our job to sieve through this information.
Having well developed or poorly developed emotional regulation skills can impact us in almost every area of our lives. As we all grow, to survive and function well in the world, we have to continue to progress with our own independence skills, otherwise referred to as our day-to-day adaptive skills. These skills include many different domains: communication skills, community use, leisure and social skills, healthy and safety, self-care and self-direction skills, and our work lives. As we list them, it can sound overwhelming, that we must continue to progress in all these areas of life all the time – but the thing is, it’s a gradual process, like taking things step by step. Healthy emotional regulation will allow us to continue to make progress where we need to.
Alongside the development of emotional regulation skills comes emotional literacy; the actual naming of the emotions that exist for us. Emotional literacy is like letter or word literacy – it is a way of reading and understanding emotions in one’s self and in others. Without it people struggle to understand what emotions they are having themselves and what other people are feeling. If difficulties in this area emerge, they will have a negative knock on effect on social interactions, which in turn will negatively impact relationships. On the flip side, developing good emotional literacy will enable positive social interactions and healthy relationships.
Adults who generally describe their emotional states in clusters (e.g. feeling angry and frustrated) are said to have lower differentiation. Differentiation is the idea that we are precise and accurate when it comes to acknowledging, and describing, our own feelings. If we were to look at differentiation a different way: lets say our degrees of differentiation are not very broad i.e. we describe the majority of our lives events and situations using the words “happy”, “sad” and “annoying” – the more vague the differentiation and the more general our labels, the less information it actually gives us, or anyone else for that matter. To make positive changes to your emotional state, you first have to know what you are dealing with. Individuals with high emotional differentiation may then describe their emotions in a more precise manner as a result (e.g. feeling rejection, disappointed and irritated) [4]. The level of differentiation that individuals have, reflects the degree to which they have the ability to distinguish different emotions from one another by being able to slot them into finer categories that is relevant to the experience at the time. As we know, knowledge is power, so the more precise we can be, the more ownership we can feel over controlling and altering how we feel. The more we understand our emotions, the better able we are to manage their manifestations, both mentally and physically. This understanding can then lead to better, more efficient communication when relaying how we feel to others.
Recognising & Acknowledging → Accurate Labelling → Understanding → Managing.
As the vocabulary surrounding one’s emotions increases, the labelling process becomes clearer. This first step however is based on the idea that an individual is honest and frank about they feel. Throughout a lifetime, many will be aware (or not so aware) of the idea of suppressing emotions. Suppressing emotions often occurs when people cognitively suppress them i.e. “
All feelings live in our bodies and our minds – but everyone keeps them in different places though. Some people might keep strong feelings like sadness or disappointment in their heart, others might keep sadness in their throat or stomach. Some people keep anger in their heads or in their hands. It is different for everyone, and feelings can also move around in our body. If this sounds like a foreign concept, then it is best to first
Mindfulness is the act of being mindful; to be present in the here and now, to use our sense to attune to our surroundings, and to feel grounded to exactly where we are. This subtle practise can look differently to different people. For example, some might like to do grounding exercises like the 5-4-3-2-1, or a relaxing body scan, others might prefer to do mindful eating with sweet or sour foods. Mindfulness is not such an alien concept as those who have not tried it yet may think. Those who read in silence, enjoy listening to rain on the window, take part in yoga or daily stretches all are enjoying a real-life example of mindfulness. One of the least complex strategies is deep breathing. This exercise is all about taking some time to breath in slowly into your stomach, breathe in four 7 seconds, hold for 2 seconds and breathe out for 11 seconds. As the saying goes, “
Take a seat or lie down on your back: let your legs relax and you arms fall to your sides. Settle yourself in a comfortable position and allow yourself to be still.
Let us begin by taking three large breath, in through the nose, and out through the mouth. Notice how your chest expands and contracts with every breath.
Now we feel relax, we are going to start to pay attention to other parts of the body. Let us go right to the bottom and start with your feet. They might feel warm or cold, restless, or calm, wet, or dry. Try your best to relax your fit now. If you are finding it hard to do, that is okay too.
Allow yourself to be still. At this very moment, there is nothing to do. Try to pay attention as best you can. If you find that is hard to do, just keep coming back to how your breathing feels.
Move your attention to your lower legs. How are they feeling? Heavy, light, restless, or calm? Do your best to give yourself a few moments of rest.
Start to move your attention up to your upper legs. Whatever you feel there, or do not feel, is fine. Just try your best to let them relax. If you feel wriggly, that’s okay, that happens.
Now move your attention to your stomach. It will always rise and fall as you breathe, like waves on the sea. You might feel something inside like hungry or full. You might even feel some emotion there too, like nervousness, sadness, excitement, or happiness.
Move your attention to your chest. Keep focusing on how it feels to take nice, deep breaths. Notice how your chest will rise and fall with every breath. If it is hard to maintain focus, that is okay. Just not ice how your breath feels in this moment.
Now bring your attention to your hands. There is no need to move them anywhere else right now. They might be resting on the floor, chair, or on your lap, stomach, or chest. Try relaxing them. Let your fingers go.
Bring your attention to your arms. Are they feeling heavy? Let go of any tension that is being held by your arms and let them feel calm, loose, and light.
Next, move your attention around to your back. Let is relax and sink into the chair or floor as much as possible. If you are finding it hard to focus, that’s okay. Just bring your attention back to your breath.
Move your attention to your neck and shoulders. Let your shoulders drop and release any tension that is being held in your neck.
Now, move your attention to your face and head. Unclench your jaw if it feels tense. Relax your eyebrows. Allow your eyes to feel light. Whenever you feel yourself thinking about something else, just return to your body and breath.
Finally, spend the next few moments paying attention to your entire bod. How does it feel? If it’s easier, continue to pay attention to your breath. If it is time to wake up, gently open your eyes and sit for a few moments before deciding its time to move again.
It is important to remember that no matter what comes out from any of the above exercises, it is crucial to accept whatever that may be. The aim is to reach a stage in which you can understand your own emotions in order to control them, not to eliminate difficult feelings altogether. All feelings are normal, and not all feelings need to be acted on. If you find yourself saying you
On the ladder of emotional regulation, acceptance of the emotional experience is step one. Acknowledge the feelings that are occurring. Less acceptance in the present moment can lead to less clarity about the nature of their current well-being, the situation that is occurring around them and the degree to which the individual can cope with it. By not fully understanding what is occurring emotionally, individuals will therefore feel less empowered to have any perceived control over the situation at all, let alone feel as though they can alter how the emotional experience plays out. There is motivational information to be found among our emotions. Our emotions often show us what is important to us, how we feel about ourselves and others and what we care about. For example, if we go to a new place that we have never been, and out gut feeling leaves us unsure if we would like to stay or not, what we could actually be feeling is fear, lack of security and discomfort. Our inner emotions guide us to that realisation.
There are two strategies that can help us emotionally regulate: preventative, and responsive strategies. A preventative strategy is when we try to modify what type of emotion we will experience and how much of it will occur
Responsive strategies are used when a trigger has occurred and the emotion has already kicked in. They are used after the fact – to help tone down the intensity of the emotion, curtail it’s manifestations or to eliminate it entirely [2]. The healthiest type of emotional regulation is the honest kind. As a society, we often feel we need to conform to how emotions should look i.e. “display rules”. This is the idea that we feel one thing internally, and display something entirely different externally; either a different emotion entirely that does not match, or an impaired version of how we feel as to behave and appear at a “socially acceptable” level of that emotion. For example, it may be socially accepted and welcomed that we are visibly very happy while out in public, in fact, this can be contagious for others, but it may not be viewed as positively to be upset in public. For us all, we feel that there is a time and place for specific emotions. However, when the line is crossed from not expressing an emotion, to not acknowledging it at all, that’s when the process of dysregulation can begin.
Emotional dysregulation occurs when an individual is unable to control their emotional responses to specific events or environments. A prolonged period of emotional dysregulation can present as excessive sadness, fear, or irritability, to give some examples. A presence of dysregulation has two main indicators: heightened emotional reactivity and psychological splitting [3]. Emotional reactivity is how responsive we are to an event, how intense our response is and how quickly we can return back to regulation once we have reached our peak. Splitting then, is the phenomenon that describes how emotionally dysregulated people fail to see the good in the bad, and the bad in the good. It is a defence mechanism that allows individuals to categories themselves and others as either “good” or “bad”. By sorting and labelling in this way, individuals are unable to see themselves and others in their entirety; as their whole being. The process of splitting can result in some high and taxing emotional costs such as major mood swings and erratic and volatile emotional states [3].
Emotional dysregulation can cause psychological discomfort. When we investigate our emotions i.e. when we feel upset, anger, disappointment or emotional hurt, we tend to act impulsively. This act of impulsivity is commonly known as the ‘fight-or-flight’ response. Pairing this response with a heightened emotional state can cause us to overreact. This overreaction is emotional reactivity. The difficulty emerges when we go beyond the point of easy and minimal-effort emotional regulation, and we may say or do things that we eventually come to regret. This regret usually makes its way to the surface once our emotions have come back down the reactivity scale i.e. when we no longer feel such heightened emotions, or our perception of certain situations change. When our views and feelings on a situation in the present moment do not match how we reacted previously, this can in turn be very uncomfortable for ourselves and those around us. Those who have not learned how to regulate their emotions can be characterised as being highly emotionally sensitive. This causes difficulty for the individual to understand their emotional experience and possess and utilise skills that can minimise and retrieve emotions back to their baseline.
Gratz and Roemer [5] acknowledge that one set of beliefs or attitudes in relation to emotions – the willingness to accept emotional experience – is an important aspect of emotional dysregulation [6]. Our mind and our bodies are connected, so we need to feel better in our minds and our bodies in order to be happier. In our bodies, we use our senses to take in information. There have been four different types of emotional regulation strategies outlined by Ochsner and Gross [7]:
Situation selection/ modification to modify appraisal inputs or cues regarding emotional situations
Attentional deployment to focus on some cues more than others
Cognitive change to change the meaning of cues
Response modulation to control the manner in which an emotion is expressed [3].
Re-regulating the body begins with breaking old habits. It is important to talk about your own feelings throughout the day to a trusting other, or if kept personal, write them down in a journal as a mindfulness practice. Explicitly label your own emotions; this can be done in very simple statements to others or into yourself. Allow yourself to accept your own emotions, and the mental and physiological response to these emotions. Try to be gentle, and show yourself compassion during this time. This also goes for when you respond to your own emotions – do so with kindness. Positive affirmations can help with the thought process of the emotion, and physical experiences can help ground the body. Once you have been honest about how you are feeling, the journey of problem-solving can begin. Encourage yourself to think of several different ways of responding to a problem and then brainstorm through each of the possible outcomes as consequences of the various courses of action.
Generally speaking, a child with typically developing social and emotional (regulation) skills is able to relate to and interact with peers and adults, and express themselves in an age appropriate manner. For a young child, this involves actively seeking out family and friends, initiating interactions with them, and responding appropriately to social advances. Actively engaging in peer relationships is also a key component of social–emotional development for young children, which involves an ability to play with other children and siblings. At this age, children learn how to express their emotions using facial expressions, their voice and their body, and they begin to understand and respond to the emotions of others [8]. Continuing into adolescents, teenagers with positive emotional regulation habits can bounce back quicker and more efficiently from stressors, form positive friendships and romantic relationships and reach goals that require more of their own independence skills. These individuals grow up to be independent, stable and achieving adults. They trust their own abilities and problem solving competencies, they have a good standard of self-worth and adapt functionally to various situations and contexts.
To recap, the steps of the process of emotional regulation are as follows:
Recognise and acknowledge the thoughts in the mind and feelings in the body
Label them – as accurately and descriptively as possible
Take some time to feel through what you are experiencing, by using your grounding and mindfulness techniques at this point
Begin to think about problem solving – be careful to not act irrationally or too quickly. Take time to think about the various courses of action that can be taken, and the consequences of each.
Environmental epidemiology is concerned with determining how environmental exposures (physical, biological, and chemical factors) affect human health [1]. It seeks to understand how various external risk factors may cause or protect against disease, illness, injuries, abnormalities, or death. These factors may be due to natural occurring or anthropogenic. Currently, environmental health issues are increasing attention in the public, media, and government, thus raising the environmental epidemiology concept as a preventive medicine. WHO reported that 1.4 million deaths per year in Europe are due to avoidable environmental exposures [2].
The environmental evidences suggested that environmental exposures influence the severity and occurrence of COVID-19. Emerging evidences support the association of environmental exposures like air pollution, chemical exposures, climate, and the built environment and COVID-19 [3]. Environmental epidemiology can design a scientific-based mitigation strategy. It can communicate to the population about the potential advantage of control strategies by placing them in context of the hierarchy of control [4]. Environmental epidemiology requires refined and different skills to attain effectively across disciplines, implement appropriate designs and methods of analyses to identify causal relationships, and design appropriate interventions. If it is so, environmental epidemiology will continue to develop novel preventive strategies that improve the quality of life and save health care costs [5].
Environmental epidemiology is one of the main important tools used in environmental management decision-making process, development of environmental standards, and policy implementation owing to monitor and assess of environmental hazards in different settings, and quantify and estimate their health impact on the population at risk [6]. One of the founders of modern epidemiology, John Snow conducted the first environmental epidemiology study in 1854. He investigated that London residents who drink sewage-contaminated water were more likely to develop cholera than those who drink clean water [7].
The study in environmental epidemiology are most frequently observational in nature, in which the investigators can look at peoples exposures to environmental factors without intervening and then observes the patterns that emerge [8]. This is the fact that it is unfeasible to conduct an experimental studies of environmental factors in humans [9]. For example, an investigator cannot ask some of their study subjects to smoke cigarettes to see if they have poorer health outcomes then subjects who are asked not to smoke. Environmental epidemiology mostly used cohort, case–control, cross-sectional, and ecological studies [8].
Environmental epidemiologists often apply a set of criteria to decide the probability that an observed relationship between environmental exposure and health consequences is truly causal [10]. The criteria commonly used whether there is a causal relationship or not are determined using Bradford Hill criteria [11]:
Strength of association: the larger an association between exposure and disease, the more likely it is to be causal.
Consistency of evidence: the same results if repeat in different time, place and person.
Specificity of association: the exposure causes only one disease.
Temporality: exposure precedes outcome.
Biological gradient: the presence of a dose–response relationship supports the causal association between an exposure and an effect.
Plausibility: reasonable pathway to link outcome to exposure.
Coherence: the cause and effect story should make sense with all knowledge available to the researcher.
Experiment: Occasionally it is possible to appeal to experimental evidence.
Analogy: the use of analogies or similarities between the observed association and any other associations.
These criteria are generally considered a guide to scientists, and it is not necessary that all criteria be met for a consensus to be reached [10].
Exposure is the contact between a stressor (physical, chemical, and biological agents) and receptor. The stressors may come from point, line, or area sources and reach the public by way of matrices of air, water, soil, and foods. Risk is a function of exposure and hazard. For instance, even for a high hazard (extremely toxic substance), the risk of an adverse outcome is unlikely if the exposures are near zero. On the other hand, a moderately toxic substance may present a substantial risk if an individual or a population is highly exposed [12].
Environmental exposures can be proximate exposure (directly leading to health conditions) such as physical, chemical, and microbiological agents, and distal exposure (indirectly leading to health conditions) such as, socioeconomic conditions, climate change and other broadly scale environmental issues. Proximate exposure occur through inhalation, ingestion, and skin contact. Whereas, distal exposure can cause adverse health issues directly by changing proximate exposures, and indirect through changes in ecosystems and other support systems for human health [13].
Exposure can be assessed by using direct and indirect methods. A direct method measure of exposure is the best measure for assessing the effect of a specific substance on the target population (e.g., biological markers and personal monitoring) [14]. A direct approach accounted the exposures through multiple media (air, water, soil, food, etc) for through one study technique. However, a direct method approach the data collection nature is invasive and need high costs. On the other hand, indirect method measures of exposure have greater utility for source emission assessment and control, since they are capable of linking population health to specific pollution emission sources (e.g., environmental monitoring, modeling, questionnaires, and diaries). To obtain good quality and much information, it is often useful to combine two or more methods. For example, personal exposure assessments are often associated with questionnaires and diaries, and may also include biomarker measurements [15, 16] as depicted in Figure 1.
Approaches to human exposure assessment methods adapted from [
Exposure assessments mainly focused on prevention. It is important to know who are exposed, source of exposure, route of exposure, levels, population with the highest risk, and health effects. The important aspects or main characteristics for the determination of exposure are the nature of the agent, the intensity of the exposure, the duration of the exposure, and the frequency of the exposure. Using these basic informations, it is possible to take appropriate measures to reduce the exposure. Exposure assessment is a complex process, involving many different professions, such as occupational hygienists, toxicologist, chemists, physicians, and environmental health professionals [17].
Exposure assessment is important for the identification, evaluation, and control of health risks in the workplace and in the general environment. Ideally, it describes the sources, pathways, route, and uncertainties in the assessment. John Snow in the 1850s noted that the apparent association between the source of drinking water and the risk of dying from cholera. Although Snow was never able to see the cholera bacteria, he understood that the disease was caused by exposure to a disease causing agent in drinking water [7, 17].
In the 1950s and 1960s, the environmental exposure and health effects began. A time-series study indicated that a disease outbreaks associated with environmental pollution, such as the London fog episode due to sulfur dioxide and mercury poisoning Minamata disease in the general population of Japan and Iraq, drew attention to the relationship between environmental exposures and public health. This brought a renaissance to the realization of the significance of environmental factors for the development of diseases [17].
Exposure to biological, physical, and chemical agents in the environment can cause a wide range of adverse health consequences. For instance, heavy metal exposure through drinking water sources is a growing global concern [18]. Assessment of exposure is an important component of environmental epidemiology research. The estimation of exposure in relation to health effects is frequently difficult, and it has generally received inadequate attention. However, afield of exposure assessment is becoming an emerging issue [1, 19].
Appropriate measures of exposure can improve the ability of a study to assess adverse effects from environmental factors. Such improvements may improve the study quality and can reduce bias, but increase cost. The exposure analysis and health outcomes must be considered together to arrive at a balanced prioritization of study requirements. One of the major example achievements by environmental exposure assessment studies is possibly the decrease in lead (Pb) exposure in the general population due to the reduction of Pb in petrol and the introduction of unleaded petrol [17]. Therefore, an effective application of exposure assessment methods may improve the results of environmental epidemiology investigations.
Exposure to potential harmful agents may lead to a wide range of adverse health effects, ranging from dysfunction, discomfort, illness (morbidity) to death (mortality) [17, 20]. The relationship between source activity, exposure, and its effect on health is described in the environmental health hazard chain as depicted in Figure 2.
The environmental health hazard chain adapted from [
Human health risk assessment is the process used to estimate the nature and probability of adverse health effects in people, groups of people, and communities, in the past, current, and in the future about certain pollutants [21]. Health risk assessment is usually carried out with a systematic approaches in response to public health concerns about the increasing incidence of health effects associated with environmental hazards due to the development of industries, urbanization, and agricultural activities [22]. Health risk assessment can provide objective scientific information and contribute to allocating resources to control exposures to environmental hazards and decision making by providing a quantitative estimation of risks [23]. However, human health risk assessment does not identify specific individuals who are exposed to a chemical, compare chemicals measured in individuals or groups of people to health outcomes, and diagnose disease.
A human health risk assessment is conducted in accordance with four steps according to United States Environmental Protection Agency (USEPA) [24]. Application of the process to different types of hazards will require different assumptions, models, and methods and these must be clearly stated at all steps.
Representation of dose and exposure adapted from US EPA [
The human exposure to pollutants can calculate as follows accordingly Eqs. (1–4) which is adopted from the USEPA [24].
Whereas,
DED = Daily Exposure Dose (mg/Kg-day).
C = concentration of substances, for water intake the unite C expressed in (mg/L).
IR = Intake Rate (m3/day).
EF = Exposure Frequency (days/yr).
ED = Exposure Duration (yrs).
CF = Conversion Factor [10−6].
AT = Average Time (days).
BW = Body Weight (Kg).
For oral ingestion:
Whereas,
I = intake of substance (food, soil, water).
AoF = An oral abserction factor or bioavailability estimate (unitless).
IGR = Ingestion Rate, for water intake the unite IGR expressed in (L/d).
For inhalation of volatiles:
Whereas,
IR = Inhalation Rate; LR = Lung Retention factor (unitless); ET = Exposure Time.
For dermal contact with soil:
Whereas,
AH = Soil adherance; SA = Surface area of skin exposed; AF=Skin absorption factor.
4.
According to Zhao et al. [27] and Ma et al. [28], children are highly exposed to heavy metals than adults due to their physicochemical characteristics (higher comparative uptake, but lower toxin elimination rates). For example, children are usually more susceptible to a given hazardous substance and likely ingest significant quantities of soil due to their finger sucking behavior and exposure via breast-feeding and placental exposure, which are generally used as the main pathways of exposure for soil metals in children.
Carcinogenic and non-carcinogenic risk assessments are used to estimate health effects due to exposure to pollutants. The non-carcinogenic risk was estimated in terms of Hazard Quotients (HQs) for the elements and exposure routes using Eq. (5). The sum of all HQs is expressed as Hazard Index (HI) Eq. (6). If HQ or HI is found to be >1, there is a chance that a non-carcinogenic health effect may occur. In contrast, if HQ or HI is found to be <1, the exposed individual is unlikely to experience adverse health effects [24].
The Carcinogenic Risks (CR) are estimated by calculating the incremental probability of an individual developing cancer over a lifetime due to exposure to a potential carcinogen using Eqs. (7) and (8) [24]. Slop Factor (SF) converts the estimated daily intake of a toxin average over a lifetime of exposure, directly to the incremental risk of an individual and the risk of an individual developing cancer. For regulatory purposes, the level of acceptable cancer risk is considered 1x10−4 to 1x10−6 [29, 30].
These parameters were calculated using the following equations:
Whereas, CDI=Chronic Daily Intake, RFD = Reference Dose, HQi = Hazard Quotients, HI = Sum of Hazard Quotient, CR = Carcinogenic Risk, and SF = Slope Factor.
An example is how environmental epidemiology studies in health risk assessment, a study conducted in Czech Republic on potentially toxic elements pollution in agricultural soil health risk assessment revealed that of the total sample locations 6.04% non-carcinogenic and 13.05% carcinogenic to children [31]. According to Oyola et al. [32] exposure to polluted sediments through incidental ingestion and dermal contact routes was the highest risk for receptors. Another study revealed that girls were more susceptible than boys to trace metal pollutants for both carcinogenic and non-carcinogenic risk [33].
Environmental epidemiology is one of the main important tools used in the environmental management decision-making process. Environmental health issues are increasing attention and emerging globally. Exposure assessment is important for the identification, evaluation, and control of health risks in the workplace and in the general environment. Exposure to biological, physical, and chemical agents in the environment can cause a wide range of adverse health consequences. Health risk assessment is the process used to estimate the nature and probability of adverse health effects in the past, current, and in the future about certain pollutants. It is usually carried out in response to public health concerns about the increasing incidence of health effects linked to changes in environmental conditions. An effective application of exposure assessment methods may improve the results of environmental epidemiology investigations.
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It is the conversion of forested land to non-forested land by humans. Deforestation occurs when a land dominated by naturally occurring trees is converted to provide certain services in response to the human demand. The indiscriminate felling of trees has resulted in a reduction of 3.16% in the global forest cover from 1990 to 2015. Although India has seen an increment in the total forest cover of ca. 1%, still there are certain regions in the country that have sought a decrease in the forest cover. The main reasons attributed to the reduction in forest cover are shifting cultivation, rotational felling, other biotic pressures, diversion of forest lands for developmental activities, etc. Continuous illicit cutting of trees has impacted the microclimatic conditions, hydrological cycle, soil quality, biodiversity, etc. of the country, thereby making the country more vulnerable for any uneventful happening. 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Sustainable forest management practices, alternatives for shifting cultivation, promotion of plantation outside the forest and the usage of certified forest products, etc. are some of the measures that can be adopted to curb the rate of deforestation.",book:{id:"7629",slug:"forest-degradation-around-the-world",title:"Forest Degradation Around the World",fullTitle:"Forest Degradation Around the World"},signatures:"Rima Kumari, Ayan Banerjee, Rahul Kumar, Amit Kumar, Purabi Saikia and Mohammed Latif Khan",authors:[{id:"276688",title:"Prof.",name:"Mohammed Latif",middleName:null,surname:"Khan",slug:"mohammed-latif-khan",fullName:"Mohammed Latif Khan"},{id:"279797",title:"Dr.",name:"Purabi",middleName:null,surname:"Saikia",slug:"purabi-saikia",fullName:"Purabi Saikia"},{id:"279806",title:"MSc.",name:"Rima",middleName:null,surname:"Kumari",slug:"rima-kumari",fullName:"Rima Kumari"},{id:"279807",title:"BSc.",name:"Ayan",middleName:null,surname:"Banerjee",slug:"ayan-banerjee",fullName:"Ayan Banerjee"},{id:"285660",title:"Dr.",name:"Amit",middleName:null,surname:"Kumar",slug:"amit-kumar",fullName:"Amit Kumar"},{id:"285661",title:"Dr.",name:"Rahul",middleName:null,surname:"Kumar",slug:"rahul-kumar",fullName:"Rahul Kumar"}]},{id:"68528",title:"Forest Biodiversity and Deforestation in Bangladesh: The Latest Update",slug:"forest-biodiversity-and-deforestation-in-bangladesh-the-latest-update",totalDownloads:1609,totalCrossrefCites:4,totalDimensionsCites:14,abstract:"Located in the Indo-Burma biodiversity hotspot, Bangladesh is a tropical country in Southeast Asia and a transitional point for flora and fauna between the Indo-Himalayan and Indo-Chinese subregions. 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In this chapter, we are going to discuss about the current management and conservation practices and issues related to the forests and wildlife of Bangladesh.",book:{id:"7629",slug:"forest-degradation-around-the-world",title:"Forest Degradation Around the World",fullTitle:"Forest Degradation Around the World"},signatures:"Ahm Ali Reza and Md. Kamrul Hasan",authors:[{id:"281012",title:"Dr.",name:"Md. Kamrul",middleName:null,surname:"Hasan",slug:"md.-kamrul-hasan",fullName:"Md. 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This chapter reviews laboratory and field methods for enumerating and manipulating earthworm populations, as well as approaches toward quantifying their influences on soil processes and biogeochemical cycling.",book:{id:"5539",slug:"forest-ecology-and-conservation",title:"Forest Ecology and Conservation",fullTitle:"Forest Ecology and Conservation"},signatures:"Dylan Rhea-Fournier and Grizelle González",authors:[{id:"82355",title:"Dr.",name:"Grizelle",middleName:null,surname:"Gonzalez",slug:"grizelle-gonzalez",fullName:"Grizelle Gonzalez"},{id:"194800",title:"M.Sc.",name:"Dylan",middleName:null,surname:"Rhea-Fournier",slug:"dylan-rhea-fournier",fullName:"Dylan Rhea-Fournier"}]},{id:"54299",title:"Remote Sensing and Forest Conservation: Challenges of Illegal Logging in Kursumlija Municipality (Serbia)",slug:"remote-sensing-and-forest-conservation-challenges-of-illegal-logging-in-kursumlija-municipality-serb",totalDownloads:1627,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Evidence convincingly shows that illegal and corrupt activities are the major underlying cause of deforestation—illegal logging contributes up to 30% of the global market, in excess of US $20 billion a year. Since so much deforestation is a result of illegal logging, we cannot rely on official production statistics to capture deforestation. Given the importance and complexity of forest preservation, an attempt was made to evaluate the possible use of a normalized difference vegetation index (NDVI) in local forest management and prevention of illegal logging and corruption. We used the example of southern Serbian municipality Kursumlija that in the 2006–2011 periods experienced a 10% loss in forest area, as the obvious result of abrupt illegal logging. This process was very easy to locate and quantify (because illegal logging produced large canopy gaps that extend from the border of Kosovo to approximately 3–4 km into the Kursumlija's territory). In short, NDVI is very promising for countries like Serbia (that rarely perform forest inventories): It is relatively cheap and quick, and it can provide forest managers with essential information; it is easy to implement; the objectivity of these methods can significantly help in avoiding corruption and illegal logging.",book:{id:"5539",slug:"forest-ecology-and-conservation",title:"Forest Ecology and Conservation",fullTitle:"Forest Ecology and Conservation"},signatures:"Miomir M. Jovanović and Miško M. 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He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. 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