Parameters in Sutherland law.
\r\n\tThis book will mainly cover work related to: (i) cells mechanosensing and mechanotransduction mechanisms (ii) computational and experimental techniques in mechanobiology, (iii) mathematical mechanobiological models of bone remodeling, (iv) bone mechano-transduction, (v) innovative tools for mechanobiology and the role of medical imaging in this field and (vi) any other proposals related to innovations, clinical application and perspectives of mechanobiology.
",isbn:null,printIsbn:"979-953-307-X-X",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"0a38ccecc83b50d8b015a6dd2533049d",bookSignature:"Prof. Abdelwahed Barkaoui",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10255.jpg",keywords:"Nuclear Mechanotransduction, Mechanosensitivity, Fluids Mechanics, Multiscale Mechanobiology, Modeling Cellular Mechanics, Finite Elements Method, Bone Remodeling, Mechanics Stimulus, Multi-scale Modeling, Mechanobiology Tools, Cell Imaging, Cell-Substrate Interactions",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 2nd 2020",dateEndSecondStepPublish:"July 23rd 2020",dateEndThirdStepPublish:"September 21st 2020",dateEndFourthStepPublish:"December 10th 2020",dateEndFifthStepPublish:"February 8th 2021",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 years",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:5,editedByType:null,kuFlag:!1,biosketch:"Assistant director of LERMA laboratory, head of mechanical discipline at ECINE and coordinator of the ECINE study program accreditation committee, a member of the editorial board of several international scientific journals, also a member of the American Society of Mechanical (ASME) Engineers European Society of Biomechanics (ESB) and the International Society of Biomechanics (ISB).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"320631",title:"Dr.",name:"Abdelwahed",middleName:null,surname:"Barkaoui",slug:"abdelwahed-barkaoui",fullName:"Abdelwahed Barkaoui",profilePictureURL:"https://mts.intechopen.com/storage/users/320631/images/system/320631.jpg",biography:"Abdelwahed BARKAOUI is an Associate Professor of Mechanical Engineering at the International University of Rabat. He obtained his University habilitation from the University of Tunis El Manar-Tunisia in 2017 and his Ph.D. from the University of Orleans, France in 2012. He has a master\\'s degree in mechanics obtained from the INSA of Lyon, France, and an engineering diploma in electromechanics from ENI-Sfax, Tunisia. Currently, dr. BARKAOUI is the assistant director of the LERMA laboratory and coordinator of the Modelling & Simulation in Biomechanics & Biomaterials (MS2B) team. He is responsible for the mechanical discipline and coordinator of the ABET accreditation project at the Higher School of Energy Engineering. His research is focused on biomechanics, mechanobiology, and biomedical engineering. He was a member of the editorial board of several international scientific journals such as Frontiers in Bioengineering and Biotechnology “Biomechanics” (IF=5,9), BMC Musculoskeletal Disorders (IF:2.6), BMC Biomedical Engineering, Series on Biomechanics, as well as a reviewer for several international journals\nin the field of biomechanics and mechanical engineering. Dr. BARKAOUI is the author of more than 60 publications in international journals, books, and conferences.",institutionString:"International University of Rabat",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"International University of Rabat",institutionURL:null,country:{name:"Morocco"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"11",title:"Engineering",slug:"engineering"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"280415",firstName:"Josip",lastName:"Knapic",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/280415/images/8050_n.jpg",email:"josip@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copy-editing and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"10198",title:"Response Surface Methodology in Engineering Science",subtitle:null,isOpenForSubmission:!1,hash:"1942bec30d40572f519327ca7a6d7aae",slug:"response-surface-methodology-in-engineering-science",bookSignature:"Palanikumar Kayaroganam",coverURL:"https://cdn.intechopen.com/books/images_new/10198.jpg",editedByType:"Edited by",editors:[{id:"321730",title:"Prof.",name:"Palanikumar",surname:"Kayaroganam",slug:"palanikumar-kayaroganam",fullName:"Palanikumar Kayaroganam"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3569",title:"Biodegradation",subtitle:"Life of Science",isOpenForSubmission:!1,hash:"bb737eb528a53e5106c7e218d5f12ec6",slug:"biodegradation-life-of-science",bookSignature:"Rolando Chamy and Francisca Rosenkranz",coverURL:"https://cdn.intechopen.com/books/images_new/3569.jpg",editedByType:"Edited by",editors:[{id:"165784",title:"Dr.",name:"Rolando",surname:"Chamy",slug:"rolando-chamy",fullName:"Rolando Chamy"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"63465",title:"Plasma-Assisted Combustion",doi:"10.5772/intechopen.80959",slug:"plasma-assisted-combustion",body:'As one of the qualified candidates for hypersonic propulsion system, scramjet combustor has attracted a large amount of attention all over the world. As is now well known, realizing high efficiency and steady combustion in a supersonic combustor always remains as a critical issue for scramjet engines. Numerous researches have indicated that the additions of cavity in combustor and the transverse fuel injection upstream of the cavity can promote the stabilization of combustion and flame [1, 2, 3]. Whereas, it is difficult yet for the fuel to reach properly mixing within the supersonic flow by the mechanical methods [4, 5]. Moreover, it is a great challenge for matching the transverse fuel jet up with the cavity under off-design condition [4]. Furthermore, certain stagnation pressure loss will appear using the approaches. Taken all account, some new methods are imminently needed for keeping stable and highly efficient combustion in combustor with the least penalties adding to the flowfield.
It is rather promising to adopt a discharge plasma for supersonic flow and/or combustion control in aerospace field [6, 7, 8]. It has been widely considered that plasma-assisted combustion is one of the most promising approaches for enhancing ignition and combustion in the environment of scramjet combustion [4, 6, 9]. As a further promising method, there are three advantages, that is: rapid response, less inertia, and flexibility [10]. Former studies clearly show that the quasi-DC discharge plasma can availably modify supersonic flow in a controllable manner among the discharge plasma mentioned above [8, 11], whereas the DBD plasma is commonly used in low-speed flow environment [12, 13]. If we can combine the quasi-DC discharge plasma with cavity and transverse fuel jet together, some new phenomena will surely appear, which may help in the improvement of combustor performance.
There in three primary mechanisms of the plasma effect on flow and combustion can be summarized: (1) momentum transfer, (2) fast local ohmic heating of the medium, and (3) active particles [6, 7, 14]. Ignoring the magnetic field, the mechanism of quasi-DC discharge plasma affecting a supersonic flow is mainly its fast local heating rather than the electrostatic force (i.e., the momentum transfer mechanism) [10, 15, 16].
This chapter aims at investigating the changes of the fuel jet, cavity, and whole scramjet combustor led by the quasi-DC discharge plasma based on the dominant thermal blocking mechanism. Here, a short cavity downstream of a fuel jet orifice is considered in order to simulate the combustor flowfield more realistic. The plasma is set as a controllable heat source. The
By applying a high voltage across the anode and cathode, a bright plasma filament appears above the two electrodes. With the impacting of incoming flow, the plasma occurs not only between the two electrodes but also several centimeters downstream on the wall [10]. In consideration of the oscillation character of its electrical parameters and mean temperature in the discharge path, this type of discharge plasma is called “quasi-DC discharge plasma.” However, it is a type of low temperature arc plasma in fact. The main properties of quasi-DC discharge plasma are described in [10, 11, 12, 15].
As depicted in Figure 1, the domain of quasi-DC discharge plasma filament is simplified as a cuboid region presented in red dashed lines for simulation based on its appearance. In Figure 1, the symmetric plotted line indicates that the cathode and anode are symmetrical for the central line of combustor wall and so does the plasma filament.
Computed configuration of quasi-DC discharge plasma in case one.
Because the quasi-DC discharge plasma releases a large amount of heat concentrated in its discharge path, the discharge path goes into very hot. This high temperature domain (i.e., the discharge path) obstructs the supersonic inflow due to a thermal blocking occurred. Hereby, the quasi-DC discharge plasma behaves as a virtual blockage in the high speed flow of scramjet combustor, which is called as “the dominant thermal blocking mechanism” [17]. On the foundation of dominant thermal blocking mechanism, the individual plasma filament can be simulated as a volumetric heat source [10, 12].
Generally speaking, the plasma input power and the effective heat power that transfers into circumambient gas are quite different. Besides, the percentage of loss commonly varies with the power supply and environment, so it is not a suitable way to use the plasma input power as the heat source value of quasi-DC discharge plasma in simulation. In order to straightforwardly describe the plasma heat strength, the average temperature of the plasma zone is acquired by using the numerical simulation here. This way is feasible when the average temperature of the plasma zone is within a reasonable range [10, 16, 18, 19]. Hence, based on the thermal blocking mechanism, a certain temperature which denotes the actuating strength (i.e., the input power) is specified for the plasma filament domain when the actuator works.
The electrodes are flush mounted and do not have influence on the main flow themselves. The length and the section dimensions of individual plasma filament heat source are 20 mm length and 3 × 3 mm, respectively. The plasma filament locates 40 mm upstream of the fuel orifice center. Besides, it is generated near the wall in the center of the combustor, which means the symmetric plane of plasma filament is within the symmetric
The unsteady Reynolds averaged 3D Navier-Stokes equations (URANS) with the
here,
where the coefficients can be found in [21]. The
where
S (K) | |||
---|---|---|---|
H2 | 273.11 | 96.67 | 8.411 × 10−6 |
O2 | 273.11 | 138.9 | 1.919 × 10−5 |
H2O | 416.67 | 861.11 | 1.703 × 10−5 |
N2 | 273.11 | 106.67 | 1.663 × 10−5 |
Parameters in Sutherland law.
Since this study focuses on the qualitative effect of plasma on the fuel jet and the scramjet combustor, the finite rate chemical model with the single step H2/O2 combustion kinetics model is applied. The reaction rate constant is derived from the Arrhenius formula. Hence, the computational time can be saved much and the well combustion flowfield can be obtained, too. The relevant parameters of H2/O2 one-step chemical model are shown in Table 2.
Equation | Pre-exponential factor | Temperature index | Activity energy [J/kg·mol] |
---|---|---|---|
9.87E + 8 | 0 | 3.1E + 7 |
H2/O2 one-step chemical model.
In order to capture the shock waves and other complex fluid structures better, the convective fluxes are evaluated using the advection upstream splitting method (AUSM) [22] with the second-order upwind approach at same time. The viscous fluxes are evaluated by using the second-order central differential scheme. Because the transport process of multispecies and the reaction both exist in the flowfield, a modified LU-SGS implicit method [23] is adopted for temporal integration.
Figure 2 shows the entire computational domain which is the half of scramjet combustor together with a short cavity and a fuel jet orifice. The inlet of combustor is located at
Computational domain and grids of the combustor.
The grids number is largely reduced by setting the symmetry face (
The entire computational domain is divided into 32 subdomains, and all assignments are completed by parallel computation on HP senior workstation, which takes about 320 h to obtain a convergence result. The inflow conditions in computation are as follows:
Three representative times are selected during one plasma control cycle for comparison after computation converged. The end of the actuator duty time (
The temperature distribution on the symmetric
Contours of temperature on the symmetric
The distribution of wall pressure near the fuel orifice on the symmetric plane of the combustor is shown in Figure 4, which is normalized by the value of the static pressure of inflow at the inlet. Compared with no plasma case, the positions that pressure starts to rise at different times move upstream from 56.6 to 52 mm due to the effect of plasma, which indicates the separation shock wave induced by the fuel jet moves upstream. And the first pressure peak decreases from 2.0 to 1.7, because of the weakening of the fuel jet induced shock on the symmetric plane. The results above are similar to the previous studies on nonreaction flow combustor [19]. More details indicate that the first pressure peak of time A is a bit higher than time B and C, but time B equals time C, which is due to the plasma control cycle too short for flow response and the duty cycle ratio also comparatively large in the flow condition here. Hence, the influence of plasma on the shock will be observed a little latter due to an inertia influence. Nevertheless, the effect of plasma on the shock wave for three typical times is highly similar on the whole.
Wall pressure distribution on the symmetric plane.
Because the separation zone upstream of the fuel orifice is primarily controlled by the separation shock wave, the size of this separation zone can be regulated by changing the location of the separation shock wave. On the one side, this zone behaves as an main ignition zone which can provide a high temperature and low flow speed environment in the scramjet combustor. On the other side, it will bring in certain pressure loss to the combustor. Hence, we can make use of the separation zone upstream of the fuel orifice by means of using the plasma with proper control parameters.
For the sake of determining the fuel mixing quality, the five cross-sectional planes distributed in equivalent ratio along the flow direction are given, as shown in Figure 5. The fuel jet arises with the actuator working, resulting in fuel decreasing near the wall including the bottom wall of the cavity. Whereas, the distribution shape of fuel in the cross-sectional planes varies from a distribution narrow and long profile into a circular profile in the upper space, which shows that the process of fuel spreading into the main supersonic flow is enhanced resulted from the plasma. Furthermore, the fuel distributions at time A are nearly the same as at time C, which is also correlated to the inertial effect mentioned above.
Distribution of equivalent ratio in cross-sectional planes. (a) Plasma off. (b) Plasma on, time A. (c) Plasma on, time C.
In Figure 6, the distribution of product water is shown. In order to distinguish the extent of product water between time A and C easily, the iso-surfaces of both are plotted by combining the half parts of them together as shown in Figure 6(b). Similar to the changes in Figure 5, more water is generated in the upper space due to plasma. Contrasted with the case without plasma actuator, the iso-surface of water expands much in its center and shrinks near the combustor wall especially downstream of cavity. These above should be attributed to the change of fuel jet spread, as given in Figure 5. Compared time A with C, the only distinction is a little more water formed at time A, which indicates that the combustion becomes weaker in the free time of a plasma control cycle.
Iso-surfaces of product water,
It can be seen that the fuel entrainment into the cavity is decreased and the combustion in cavity becomes weaker due to the plasma, as given in Figures 5 and 6.Whereas, the two figures also show that more fuel penetrates into the supersonic air flow, so the mass exchange between the inside cavity and its outside is enhanced due to the plasma. Hence, the plasma improves the fuel mixing above the cavity prominently, which can also be realized as the calculation results of combustion efficiency in Section 2.2.4.
The stagnation pressure recovery coefficient can indicate the pressure loss in a combustor, so it is an important index. When the stagnation pressure recovery coefficient goes up, the capability of combustor outflow will be enhanced. So, it is defined as the ratio of combustor outlet stagnation pressure to inlet stagnation pressure [24]. In fact, calculating the mass flow weighted mean stagnation pressure can gain the stagnation pressure in a cross section.
where
where
The calculated data about the stagnation pressure are given in Table 3. In order to analyze the tendency of stagnation pressure loss coefficient further, the average stagnation pressure at the outlet is replaced by the average stagnation pressure at different positions, as shown in Figure 7. At the actuator working time or even at the free time, the stagnation pressure loss can both be increased due to the plasma, as given in Table 3. In (7), the relative change rate of
where
Index of performance | Case | |||
---|---|---|---|---|
Plasma off | Plasma on, time A | Plasma on, time B | Plasma on, time C | |
1,098,093 | ||||
916,532 | 882,270 | 888,143 | 885,268 | |
0.83466 | 0.80346 | 0.80880 | 0.80619 | |
0.16534 | 0.19654 | 0.19120 | 0.19381 |
The inlet mean stagnation pressure
Distribution of the stagnation pressure loss coefficient.
In Figure 7, the difference of stagnation pressure loss between plasma cases is shown where no plasma case enlarges along the flow direction (
The combustion efficiency
where
Figure 8 plots the distribution of combustion efficiency in
Distribution of combustion efficiency downstream of fuel orifice.
In order to define the cost to effectiveness of quasi-DC plasma, it is calculated in value
The main results in this section are as follows: (1) The distribution of relatively high temperature zone moves downstream prominently due to the heat release from the quasi-DC discharge plasma. The separation shock wave induced by the fuel jet is partly weakened and moves upstream due to the plasma, which can regulate the size of recirculation zone upstream of the fuel orifice. (2) The fuel jet moves upward integrally resulted from the plasma heating effect. The fuel spread wider along the spanwise and penetrates into the leading flow deeper, resulting in the cross-section shape of the fuel jet varying from a narrow and long profile to a circular profile. Because of the variation of fuel mixing, in the upper space, more water forms while less appears near the wall compared with the case without plasma. (3) The stagnation pressure loss of combustor increases a little as actuator works, but the combustion efficiency in the combustor rises obviously. These above can be summarized as the comprehensive effects of flow structure changes caused by the plasma, including waves induced and heat transfer. Since it is negligible for the relative change of stagnation pressure recovery coefficient in the actuator working cases, and the ratio of deposited plasma energy to the increased combustion heat release is very little, it can be obtained that the quasi-DC discharge plasma can make more benefits than penalties for the scramjet combustor, when proper adopting control parameters of the plasma actuator.
On account of the direction of the quasi-DC discharge path for the inflow, the discharge modes include two types: longitudinal mode and transversal mode [12]. In case one, the quasi-dc discharge operates under transversal mode, while in case two, a longitudinal mode is adopted for the configuration. As shown in Figure 9, there are five anodes set upstream of the backward wall of cavity, while in the bottom wall of cavity the five cathodes are set. The five pairs of identical electrodes are arranged parallel and symmetrically. Besides, the flow will not be disturbed directly resulted from all the electrodes flush mounted in the wall. A filament plasma forms when applied a high voltage (generally 150–1200 V) between anode and cathode, which acts as strongly oscillating and bright and looks like an inverted “L” crossing the backward wall of cavity. Since the major heat energy of the quasi-DC discharge plasma focuses on the bright filament domain [10, 25], the filament plasma domain can be established in such a simplified shape as given in Figure 9.
The schematic of plasma filaments in the cavity.
Just like the way given in case one, every quasi-DC plasma filament is dealt as a volumetric heat source. To represent the plasma heat strength reasonably, the mean temperature of the plasma domain
Three representative times are chosen from one plasma cycle, which consists of the later actuator free duration and the actuator working duration, for comparison after computations converged. In the simulation, the duration of one plasma cycle is
The Mach number distribution of local cavity flowfield on the symmetrical
Mach number distribution: (a) no plasma; (b) with plasma, time A; (c) with plasma, time B; (d) with plasma, time C.
Owing to the periodic heat release from the plasma filaments and the thermal blocking functions, the plasma filaments behave as five knives cut the cavity shear layer. Hence, the mass transportation process will be disturbed by this “cutting” effect, and the moving direction of original shear layer has to be changed also. And then, the turbulence intensity and vorticity magnitude both are increased, so the fuel and air existing around the original shear layer can exchange through the cavity mouth more easily. Furthermore, the combustion enhancement downstream or over the cavity causes the decrease of local flow velocity, which results in the rise of local static pressure and blocks the incoming flow.
Figure 11 presents the distributions of wall pressure near the rear edge of cavity on
Wall pressure distribution near the rear edge of cavity. (a)
As presented in Figure 11b, the wall pressure of cavity rises distinctly on
Because the distributions of combustion products may be impacted by the change of cavity shear layer and waves, the mass fraction iso-surface of water (
Iso-surface of product water,
The above phenomena can be attributed to the reasons as follows: (1) Plasma filaments existed upstream of the cavity front edge release a large amount of heat, so the local static temperature increases and then the movement of fuel jet is promoted toward upper space. Because of the larger velocity far from the bottom wall (i.e., flow moves faster in the middle height of the combustor), the original product water will surely move downstream quickly. Therefore, the little water is found around the orifice when plasma actuators work, and the symmetry structures are formed in higher space downstream. It can be verified from the “branch pipes” presented in Figure 12b–d. (2) As stated above, the periodic fluctuation of cavity shear layer is related to the plasma filaments “cutting” effect on it, and then the mass transportation process is blocked which leads to the obvious change of combustion over the cavity. Hence, it affects the distribution of product water. Meanwhile, notice that the “branch pipes” curve structures match with the typical spanwise reverse vortex pairs in shape. Generally speaking, the spanwise reverse vortex pairs can extend the contact area between air and fuel by the methods of entraining air into its fuel core, which makes the mixing between fuel and air better and also the local combustion efficiency arisen. Whereas, the periodic disturbance from the plasma filaments impels the air and fuel transporting in the
The drag and mass exchange rate of cavity are two important cavity performance parameters [26]. The combustor’s drag is mainly generated by the cavity as it has a nearly constant cross section. The cavity drag includes two types: pressure drag and friction drag. Pressure drag is defined as the difference value between the force on cavity front wall and rear wall. Usually, the friction drag is too small compared with pressure drag so it always can be ignored. So the pressure drag is regarded as the cavity drag here. The drag coefficient of flame holding cavity is defined as:
where
In Table 4, the calculation results of the cavity drag and its drag coefficient are listed. It can be observed that the drag coefficient is 0.060 at the no plasma case, which is smaller than time B and C but larger than time A. In view of the change of cavity shear layer in Figure 10, it should be due to the moving upward of the shear layer as actuator works. As the shear layer moves upward, it deflects to the main flow and no more impacts on the cavity rear wall so the drag decreases. However, at time B and C, because of the variation of the shear layer fluctuation, stronger impact may appear the rear wall of cavity, and the combustion may be boosted in the cavity rear part, which can both lead to the increase of back pressure in the cavity. Considering the drag coefficient values at the three typical times, the time weighted average cavity drag coefficient is calculated to be 0.0668 which means the cavity drag usually increases by the plasma.
Front wall | Rear wall | Drag | Drag coefficient | |
---|---|---|---|---|
No plasma | −19.8 | 34.3 | 14.5 | 0.060 |
Plasma, A | −19.6 | 33.1 | 13.5 | 0.056 |
Plasma, B | −19.6 | 37.6 | 18.0 | 0.075 |
Plasma, C | −18.1 | 33.5 | 15.4 | 0.064 |
Calculation results about the cavity drag, unit: N.
As we know, the cavity drag in reaction flow is closely related to the combustion heat release zone of a cavity. So only reducing the cavity drag may not bring benefit for the whole combustor. It can be seen that the further detail analysis about the combustion distribution in flowfield should be done to understand the effect of plasma on the cavity performance.
The mass exchange rate of cavity
The mass exchange rate of cavity is given in Table 5. Because the species transportation is achieved through the vortices in the cavity shear layer, it is very significant for enhancing the diffusion ability of cavity shear layer. Owing to the break on the original stable structure of the shear layer resulted from the plasma filaments “cutting” effect, the mass exchange rates at plasma existing cases at times A, B, and C are 9.2, 197.2, and 107.8 times, respectively, than the “no plasma” case. In addition, the time-weighted average mass exchange rate is 8.217 g/s, which is 122.6 times than the “no plasma” case. And the variation of the mass exchange rate magnitude from time A to C is in related to fluctuation degree of cavity shear layer. As a result, the quasi-DC plasma does obviously promote the species transportation between external and internal cavity.
No plasma | Pulse, A | Pulse, B | Pulse, C | |
---|---|---|---|---|
0.067 | 0.614 | 13.013 | 7.223 |
Calculation results of cavity mass exchange rate, unit: g/s.
In the research fields related to “sound cavity,” “embedded magazine” and “flame holding cavity,” the dynamic study on pressure oscillation in a cavity is always greatly valued around the world [27]. According to the cavity shear layer distribution, four monitor points are chosen to capture the dynamic pressure feature, as shown in Figure 9. F-1 is located on the front wall of cavity with
where
The SPLs of F-1, F-2, R-1, and R-2 are 168, 193, 188, and 191 dB, respectively. However, at the no plasma case, their SPL values are 120, 118, 124, and 106 dB, respectively. It indicates that the SPL of all the monitor points go up sharply, and the relationship between point location and magnitude of SPL changes prominently. The points are near the mouth of cavity and the effect of plasma filaments on the cavity edges is strongest, so the SPL magnitude increases here. Moreover, through the analysis on cavity drag in Table 4, the conclusion can be obtained that the pressure disturbance on the monitor points is controlled by combustion, and the shear layer strongly affects the change of local combustion.
In Figure 13, the frequency spectrum characteristics of R-1 and R-2 by FFT are depicted. The several dominant frequencies of pressure oscillation are marked with red circles here, which show that the first dominant frequency is almost the double of the plasma actuation frequency 5 kHz. Whereas, it is barely equal to the plasma actuation frequency under nonreaction condition [19]. Furthermore, nearly every dominant frequency is an integer multiple of the plasma actuation frequency. The results above indicate that the pressure oscillation in the cavity is controlled by both local combustion flowfield and the plasma actuation frequency.
The normalized pressure frequency spectrum, with plasma. (a) R-1. (b) R-2.
The combustor stagnation pressure recovery coefficient of time A, B, C, and the no plasma case is 0.75, 0.81, 0.65, and 0.83, respectively. And the calculated time weighted average stagnation pressure recovery coefficient is 0.73. It suggests that the overall stagnation pressure loss is raised due to the plasma filaments, especially for time A and C. The increase of the combustor stagnation pressure loss is caused by several factors, such as the enlargement of separation zones, the rise of back pressure induced by local combustion and the strengthening of shock waves, which is based on the analysis of cavity shear layer and wall pressure distribution.
Considering the interesting variation of product water distribution as shown in Figure 12, the distribution of combustion efficiency in the flow direction may also vary influenced by the plasma filaments. Hence, the combustion efficiency
Combustion efficiency along
In a word, the combustion efficiency increases downstream of the front wall of cavity in most of the time due to the plasma. It becomes lower than the no plasma case at several positions for few moments, but the decrease is comparatively small. Furthermore, during one plasma cycle, the combustion efficiency gradually increases from beginning to end, which indicates that the plasma performs better during actuator free period for the pulsed actuation mode.
The ratio of power consumption of the plasma actuator to the increased combustion heat release of the combustor is calculated in value
The main results are as follows: (1) Because of the “cutting” effect of quasi-DC plasma filaments, the cavity shear layer becomes fluctuating and the local combustion changes which also results in the variation of wall pressure distribution near the cavity rear edge. On the mass fraction iso-surface of product water several “branch pipes” curve structures form periodically, which can be put down to the influence of plasma on the local combustion. (2) The effect of plasma on the cavity drag is relatively perplexing and the drag coefficient value is observed to be unsteady. Nevertheless, the mass exchange rate goes up prominently due to plasma, and the magnitude change from time A to C is in agreement with the fluctuation degree of cavity shear layer. (3) The SPLs of four cavity monitor points rise, and the frequency spectrum of monitor points near the rear edge presents that the first dominant frequency is twice the plasma actuation frequency, under the effect of plasma. Hence, the pressure oscillation in the cavity is controlled by both the plasma and local combustion flowfield. (4) On the one side, the combustion efficiency is usually increased due to plasma, and on the other side, the certain pressure loss increases resulted from the changes of combustion and waves in the flowfield by the plasma. Because the ratio of deposited plasma energy to the increased combustion heat release is extraordinarily small, it is considered that if optimal actuation parameters of the actuator are chosen the quasi-DC plasma can bring more benefits than penalties for the cavity in scramjet combustor.
This work is sponsored by the National Natural Science Fund of China, No. 51876219, No. 91441123, and No. 51777214. The authors would like to acknowledge the help of Dr. W. Feng in numerical simulation.
The authors declared that they have no conflicts of interest to this work.
Wireless sensor networks (WSNs) have been shown in a range of applications during the past several years. A WSN is a collection of wireless devices that are typically small, battery-powered, and self-contained (also known as nodes). These devices include on-board computers, communication, and sensing capabilities, enabling them to monitor and transfer data on physical or environmental factors like temperature, sound, and pressure through a unidirectional or bidirectional network. The nodes are made up of a low-power CPU with limited processing, a memory device with limited storage capacity, a radio transceiver with low-power internal/external antenna, a low-data rate and limited range, sensors (scalar, cameras, microphones), and a power supply (batteries and solar cells). In most cases, each device is powered by a battery. Examining each of these gadgets individually may seem to be pointless.
WSNs play an important role in military applications. The increasing deployment of WSNs drives sensor network research. WSNs, on the other hand, maybe used for environmental monitoring, habitat monitoring, classroom/home monitoring, structural monitoring, and health monitoring, among other things. Based on its characteristics, each application has its own design concept and execution to meet its own demands. The qualities of WSN, together with technology improvements, give the greatest benefits to healthcare. A sensor network designed to identify human health indicators is known as a body sensor network (BSN). Because BSN nodes are directly attached to the human body, considerable vigilance is required. For many days, several healthcare applications need the BSN to collect patient data indefinitely without user intervention. Such applications must take into consideration the energy constraints of sensor networks [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15].
The challenges of WBS networks healthcare is a need for everyone’s quality of life in today’s environment. The population of developed countries is growing at a pace that is proportional to the government’s budget. Healthcare systems will face challenges as a result of this. One of the most difficult challenges is making healthcare more accessible to elderly people who live alone. In general, health monitoring is done on a check-in basis, with the patient remembering their symptoms; the doctor performs tests and develops a diagnosis, then monitors the patient’s progress throughout therapy. Wireless sensor network applications in healthcare provide in-home assistance, smart nursing homes, clinical trials, and research advancement. Let’s take a look at some of the challenges and basic features of BSNs before we get into the medical uses of this technology. In healthcare applications, low power, limited computing, security and interference, material restrictions, resilience, continuous operation, and regulatory requirements with elderly people are all issues.
Modern modelling approaches such as fuzzy logic (FL) and artificial neural networks (ANN) are frequently employed in hydrological modelling for a number of applications. The main benefit of these techniques is that they are not constrained by restrictive assumptions such as linearity, normality, or homoscedasticity and that they provide promising and acceptable alternatives to classical stochastic hydrological modelling in time series analysis, such as the auto regressive moving average exogenous (ARMAX) model (autoregressive moving average with exogenous inputs). When applied to hydrological systems, however, traditional stochastic models have many drawbacks, the most notable of which are short-time dependence and the normality assumption, as previously mentioned. Hydrological processes are well recognised for defying these assumptions. ANNs have been recognised as a tool for modelling difficult nonlinear systems and are widely used for hydrological prediction. Their applications range from forecasting hourly and daily river stages to further FL modelling applications in: rainfall-runoff groundwater; and time series modelling [6, 7, 8, 9, 10]. Fuzzy neural networks (FNN) are a unique approach for river flow prediction that blends FL and ANNs.
Because they can estimate any continuous function to any degree of accuracy, the Mamdani and tidal sequence (TS) systems are referred to as universal approximators. The smaller the error tolerance, the more fuzzy rules are necessary. In practise, fuzzy models can always yield nonlinear modelling solutions when the required number of fuzzy sets and rules are provided. In comparison to the TS approximator, the Mamdani approximator has the benefit of being able to use both numerical and verbal data produced from human knowledge and experience.
When nontrapezoidal/nontriangular input fuzzy sets are used, TS fuzzy systems may be more cost-effective than Mamdani fuzzy systems in terms of input fuzzy sets and fuzzy rules. They discovered that TS and Mamdani fuzzy systems have comparable minimal system configurations when trapezoidal or triangular input fuzzy sets are used. The performance of Mamdani (linguistic) and TS (clustering-based) fuzzy models was examined in the spatial interpolation of mechanical features of rocks. In terms of prediction performance, the clustering-based TS fuzzy modelling technique beats the Mamdani model, according to their results. The main purpose of this study is to develop a hybrid model for streamflow forecasting that incorporates both a genetic algorithm and fuzzy logic. Genetic algorithms and neural networks (NNs) were used to train the Mamdani and Takagi-Sugeno fuzzy logic modelling systems, respectively. According to the comparison, the Mamdani approach beats standard methods in terms of avoiding restrictive assumptions, insight into the modelling structure, and modelling accuracy.
Health is always a major concern as the human race improves in terms of technology. The current coronavirus outbreak, which has hurt China’s economy to some extent, exemplifies how healthcare has become more vital. In areas where the pandemic has spread, it is always preferable to monitor these people using remote health monitoring equipment. As a consequence, the current solution is a health monitoring system based on the IoT. Remote patient monitoring provides for patient monitoring outside of typical clinical settings (for example, at home), increasing accessibility to human services offices while cutting expenses. This project’s primary purpose is to design and build a smart patient-health monitoring system that uses sensors to monitor patient health and the internet to alert loved ones if there are any issues. The purpose of developing monitoring systems is to reduce healthcare costs by reducing the number of needed inspections. In an IOT-based framework, different consumers may be able to see sensitive aspects of the patient’s blooming. Because the information should be double-checked by visiting a website or URL, this is the case. In GSM-based patient observation, the rising parameters are communicated utilising GSM through SMS techniques.
In most rural areas, the medical facility would not be within walking distance of the residents. As a consequence, the majority of people must attend doctor’s visits, stay in hospitals, and undergo diagnostic testing procedures. Each of our bodies uses temperature and pulse recognition to determine our overall health. The sensors are linked to a microcontroller that monitors the state and, as a result, is interfaced to an liquid crystal display (LCD) as well as a remote connection that may send alarms. If the framework detects any unusual changes in heart rate or body temperature, it warns the client through IoT and also shows subtle features of the patient’s pulse and temperature on the web in real-time. An IoT-based tolerant wellness monitoring framework efficiently leverages the web to monitor quiet wellbeing metrics and save time in this manner. There is a significant ability to disregard any form of minor health concern, as shown by changes in important components such as body temperature, pulse rate, and so on in the early stages.
When a person’s health condition has developed to the point that his or her life is in peril, they seek medical assistance, perhaps wasting money. This is crucial to consider, especially if an epidemic spreads to a place where doctors are unavailable. Giving patients a smart sensor that can be monitored from afar to avoid the spread of sickness would be a realistic solution that might save many lives. Sensors monitor physiological signs, which are transformed into electrical impulses when a patient enters the healing centre. The basic electrical flag is then updated to an advanced flag (computerised data), which is then stored in RFID. To transfer computerised data to a local server, the Zigbee Protocol is employed. For this framework, Zigbee is a good choice. In this location, there are the most cell hubs. It’s better for gadgets that are smaller and use less energy. A nearby server sends information to the therapeutic server through WLAN.
When the data is transmitted to the therapeutic server, it checks to see whether the patient already has a medical record, then adds the new information to that record and sends it to the specialist. If the patient has not had any prior treatment records, the server creates a new ID and stores the data in its database. The IoT is becoming more widely recognised as a feasible solution for distant value tracking, notably in the field of health monitoring. It permits the secure cloud storage of individual health parameter data, the decrease of hospital visits for routine checks, and, most critically, the remote monitoring and diagnosis of sickness by any doctor. In this research, an IoT-based health monitoring system was developed. Body temperature, pulse rate, and room humidity and temperature were all measured by sensors and shown on an LCD. The sensor data is then wirelessly sent to a medical server. These data are then delivered to a smartphone with an IoT platform that belongs to an authorised person. Based on the findings, the doctor diagnoses the condition and the patient’s current state of health.
The advantages of AI have been extensively researched in the medical literature. Using complicated algorithms, AI can ‘learn’ characteristics from a large quantity of healthcare data and then apply the results to clinical practise. It might potentially include learning and self-correcting capabilities to improve accuracy as input changes. AI systems that give up-to-date medical information from journals, textbooks, and clinical practises may support physicians in providing proper patient care. In addition, an AI system might help to reduce diagnostic and therapeutic errors, which are inevitable in human clinical practise. Furthermore, an AI system extracts important data from a large patient population to assist in the generation of real-time health risk warnings and prediction findings [11, 12, 13, 14, 15].
In this chapter, we look at the current level of AI in healthcare and predict its future. First, we will go over four crucial factors from a medical researcher’s perspective: (1) Justifications for AI use in healthcare, and (2) The sorts of data that AI systems have examined AI devices may be classified into two classes, according to the previous description. The first category includes machine learning (ML) approaches that analyse structured data such as imaging, genomics, and EP data. ML algorithms are used in medical applications to cluster people’ traits or forecast the probability of sickness consequences. The second category includes natural language processing (NLP) tools, which extract information from unstructured data such as clinical notes and medical journals to supplement and enrich organised medical data. Texts are converted into machine-readable structured data, which may then be analysed using ML algorithms.
Lung- and heart-related ailments are at the top of the list of health-related problems/complications. Wireless technology, which is a relatively new concept, may be used to track one’s health. Wireless health monitoring systems make use of wearable sensors, portable remote health systems, wireless communications, and expert systems, among other technologies. Life is valuable, even a single life is valuable, but people are dying due to the lack of health facilities, sickness awareness, and sufficient access to healthcare systems. In all conditions, the IoT assists in the identification of diseases and the treatment of patients. In IoT healthcare systems, there are wireless systems in which different applications and sensors are linked to patients, information is gathered, and the information is communicated to a doctor or specialist through an expert system. Medical devices for the Internet of Things (MD-IoT) are connected to the Internet and use sensors, actuators, and other communication devices to monitor patient health. The expert system uses these devices to transfer patient data and information to a secure cloud-based platform, where it is stored and analysed.
Telemedicine is the practise of caring for a clinician and a patient while they are not physically present with each other. ‘The delivery of healthcare services at a distance’ is how telemedicine is defined. Telemedicine provides a variety of benefits, but it also has many disadvantages. Providers, payers, and politicians all recognise the difficulty of navigating some grey zones. While the sector will rapidly develop over the next decade, it will also provide practical and technological challenges. IoT is the most trustworthy and cost-effective alternative in certain circumstances, and the connection between different devices and interactive communication systems also need further formal examination. By communicating information to healthcare teams such as doctors, nurses, and specialists, IoT (Internet of Things) and mobile technologies make it easier to monitor a patient’s health. Professionals would benefit from using the store and forward method to save and collect patient data that could be accessed at any time.
A smart healthcare system is a piece of technology that enables patients to be treated while also improving their overall quality of life. The smart health concept incorporates the e-health concept, which emphasises a number of technologies such as electronic record management, smart home services, and intelligent and medically connected items. Sensors, smart devices, and expert systems all help to create a smart healthcare system. Healthcare facilities are a big concern in today’s globe, especially in developing countries where rural areas lack access to high-quality hospitals and medical experts. Artificial intelligence has benefited health in the same way it has benefited other aspects of life. The IoT is expanding its capabilities in many areas, including smart cities and smart healthcare. The IoT is now being used in healthcare for remote monitoring and real-time health systems. Controlling and preventing catastrophic events, such as the one that happened in 2020 when the coronavirus disease (COVID-19) ravaged the world, maybe done via IoT technologies without imposing severe restrictions on people and enterprises. COVID-19, unlike SARS in 2003, causes respiratory symptoms and seems to be more contagious. One way to restrict viral transmission until a vaccine is developed is to keep a close eye on physical (or social) distance. Improved surveillance, healthcare, and transportation networks will make it less probable for contagious diseases to spread. An IoT system combined with artificial intelligence (AI) may give the following advantages when considering a pandemic: (1) utilising surveillance and image recognition technologies to enhance public security, (2) using drones for supply, transportation, or disinfection, and (3) leveraging AI-powered apps and platforms to monitor and limit people’s access to public places.
In healthcare, an IoT system is often made up of a number of sensors that are all connected to a computer and allow real-time monitoring of the environment or patients. AI-assisted sensors might be employed in the case of a pandemic to help predict whether or not people are sick based on symptoms like body temperature, coughing patterns, and blood oxygen levels. The ability to monitor people’s locations is another useful function. During an outbreak of severe disease, tracking the distance between people may provide vital information. Using technologies like Bluetooth, we can get a good estimate of how much distance people maintain when walking in public places. This information might be used to target people who are not physically separated by a specified distance, such as 2 m, to stop the virus from spreading further. To prevent the abuse of personal information, security and data management must be addressed throughout the development of such platforms. Following a pandemic, governments may try to use these platforms and data for long-term monitoring to control and monitor people’s behaviour.
One of the problems with traditional medical diagnosis is its inaccuracy and imprecision, which has resulted in the deaths of thousands of people. The development of various algorithms, models, and technologies to ensure accuracy and precision has considerably reduced the number of people who die every day in hospitals, and fuzzy logic, a branch of artificial intelligence, is one of these technologies. Medical diagnostic processes are carried out with the use of computer-assisted technologies, which are growing more common by the day. These systems are based on AI and are designed to diagnose as well as recommend treatments based on symptoms. Many decision support systems (DSSs) have been developed in the medical field, such as Aaphelp, Internist I, Mycin, Emycin, Casnet/Glaucoma, Pip, Dxplain, Quick Medical Reference, Isabel, Refiner Series System, and PMA, to assist medical practitioners in their decisions for diagnosis and treatment of various diseases.
The medical diagnostic System (MDS) is used to diagnose various ailments in an expert system like this. Fuzzy logic was chosen as the AI tool in the recommended system since it is one of the most efficient qualitative computational approaches. Fuzzy logic has been proved to be one of the most effective techniques to offer clarity to the medical field. Medical applications include CADIAG, MILORD, DOCTORMOON, TxDENT, MedFrame/CADIAG-IV, FuzzyTempToxopert, and MDSS, to name a few.
Control systems, household appliances, decision-making systems, and the medical and automotive industries all use fuzzy logic-based automated systems. Some of the concepts used in fuzzy logic include fuzzification, defuzzification, membership function, rules, domains, linguistic variables, and so on. While Boolean algebra’s set values are confined to 0 and 1 or False and True, fuzzy logic proposes that there are extra values between 0 and 1 or False and True, referred to as in-between values. To put it another way, on its set of 0 and 1, Boolean logic employs entirely inclusive and exclusive rules, while fuzzy logic employs wholly inclusive, exclusive, and ‘in between values’ rules. Both expert systems and fuzzy logic control systems are designed to tackle difficult and intricate jobs, but a fuzzy logic control system has the benefit of being able to cope with ambiguity. Language standards are employed to enhance decision-making in the face of uncertainty, emulating a human operator. This decision-making power saves time and reduces or eliminates the need for the human element in control models, which was previously required. A closer look into this cluster reveals that similar themes include the use of intelligent data analysis and related domains to anticipate outbreaks, simulate disease transmission, and screen for the virus on a broad scale. Epidemiology is the term used to describe all of this. Modelling and forecasting the spread of COVID-19 using AI and ML methods may help governments, health organizations, corporations, and people manage the pandemic. In this regard, NNs have also played a significant role. To forecast situations, multi-layer feed-forward NNs and convolution neural networks (CNNs) were utilized. Other well-known algorithms for predicting time series data, such as ARIMA (auto-regressive integrated moving average model) and support vector machine (SVM), have been studied. Several of these models have been used to estimate daily infections during various sorts of lockdowns, assisting government decision-making. Public policies have been effectively planned using ML approaches.
In the creation of vaccines, AI and intelligent data analysis have also proven critical. ML and AI are particularly useful for repetitive activities that need large-scale data processing, making them ideal for drug-development. Deep learning has shown to be a very useful technique for predicting the qualities and uses of pharmaceutical compounds that might trigger a body’s immune response to an illness. Because this analytical method often needs long periods of testing and a considerable expense, automating this contact would be quite beneficial. Scientists have developed algorithms that anticipate which immunogenic regions should be included in a vaccine, allowing the immune system to learn and prepare for specific antigens. Antigens already found in pathogens that may be related to antigens for a new infection may also be recognised by AI, speeding up the process even further.
AI is assisting in the development of vaccines by simplifying the comprehension of viral protein structures and assisting clinical professionals in sifting through hundreds of relevant study findings at a faster rate than would be achievable otherwise. The ability to understand the structure of a virus may aid in the creation of effective vaccination.
AI and soft computing (SC) play a crucial role in healthcare medical diagnostics. Doctors nowadays are unable to advance without the help of technological advancement. This digital advancement will be incomplete if AI and SC are not included. AI is a technique for constructing intelligent machines. The SC is a collection of computer algorithms for seeing and learning real-world information, which allows computers to create AI. As a consequence, the computer can perform as well as a person if the philosophy of human labour can be expressed using AI and SC technologies. In the healthcare sector, this technological development is being used for long-term medical diagnosis. AI is defined by Alan Turing, the discipline’s inventor, as ‘the science and engineering of building machines, especially sophisticated computer programmes.’ Artificial intelligence systems are computer programmes that can mimic human cognitive processes.
In the early phases of AI, philosophy, potential, demonstrations, dreams, and imagination all played a part. In response to a variety of conflicting needs, possibilities, and interests, the field of IA developed. In a range of fields, including healthcare, AI combined with analytics (AIA) is becoming increasingly commonly employed. Medicine was one of the most successful applications of analytics, and it is now a prospective AI application sector. As early as the mid-twentieth century, clinical applications were designed and provided to physicians to assist them in their practise. Among the applications are clinical decision support systems, automated surgery, patient monitoring and assistance, healthcare administration, and others. The current methodologies are mostly focused on knowledge discovery via data and ML, ontologies and semantics, and reasoning, as we will see in the next sections. We will look at how AI has advanced in healthcare over the last 5 years in this piece.
Data mining, ontologies, semantic reasoning, and ontology-extended clinical recommendations, clinical decision support systems, smart homes, and medical big data will be the focus of the examination. The multiple artificial intelligence features of our study were not chosen at random. Indeed, we have noticed that they have developed a strong interest in medicine in recent years. Data mining methods are used in learning and prediction, as well as picture and speech processing, and anything involving emotion and sentiment. Because of their ability to reason, as well as its usage as a way of learning, sharing, reuse, and integration, ontologies have gained momentum in medicine. Clinical decision support systems that assist improve the quality of treatment in clinical practise draw on both disciplines. They are also used in smart homes to help those with cognitive impairments with daily tasks. Big data in medicine is becoming increasingly common, and its application in analytics is unavoidable.
Electricity engineers formerly concentrated their efforts on the production and transmission levels, with the distribution system receiving less attention. Engineers have only recently been provided with the tools necessary to cope with the computational burden of distribution systems to undertake realistic modelling and simulation. The majority of primary distribution systems are built up in a radial configuration, with one end providing each load point. The radial type system is the simplest and most often used for effective coordination of their protective systems. Fuzzy set theory has been developed and used in a range of engineering and non-engineering domains where the evaluation of actions and observations is ‘fuzzy’ in the sense that no clear boundaries exist. The fuzzy set theory provides for the inaccurate representation of evaluations and observations, which may then be utilised to describe and solve issues.
The use of fuzzy set theory to distribution system analysis may aid professional judgement and prior knowledge in distribution system planning, design, and operations. Future computer technology will be considerably more advanced than our greatest imaginations, and far more advanced than anything we can envision right now. The IoT is one of the most cutting-edge technologies, with IoT-enabled things all around us. With the help of RFID (radio frequency identification) and sensors, it will create its own world in which everything will be managed and transmitted over the Internet. The devices will create their own environment. The enormous amount of data created will be recorded, analysed, and presented in a timely, seamless, and understandable way. Cloud computing will provide us with virtual infrastructure for visualisation platforms and utility computing, enabling us to integrate device monitoring, storage, client delivery, analytics tools, and visualisation in one place. Cloud computing, which will provide an end-to-end solution, will allow users and businesses to access applications on-demand from anywhere. One of the most important IoT applications is in the field of healthcare. We designed a health monitoring device using current low-cost sensors to monitor and maintain human health parameters such as heart rate, temperature, and air quality. The approach of fuzzy logic was used. In 1965, Lotfi Zadeh presented the concept of fuzzy logic for the first time.
Fuzzy logic is a kind of multivalued logic with truth values ranging from 0 to 1. Fuzzy logic deals with the concept of partial truth, in which the truth value varies from completely false to completely true. The fuzzy logic technique includes fuzzification, inference, and defuzzification. The sensors capture crisp input data, which is then converted via membership functions into a fuzzy input set, linguistic words, and linguistic variables. The rules are used to make inferences. The system will work on the same principles as the IF-THEN system. The membership function is used to convert the fuzzy output to crisp output.
Vital signs are the four most important markers that reveal the condition of the body’s vital functions. These measurements are used to assess a person’s general physical well-being, detect probable diseases, and monitor healing progress. The fuzzy inference system is a computer framework that makes choices based on fuzzy set theory, fuzzy if-then logic, and fuzzy reasoning. Over the last decade, fuzzy set theory has advanced in many directions, with applications in taxonomy, topology, linguistics, automata theory, logic, control theory, game theory, information theory, psychology, pattern recognition, medicine, law, decision analysis, system theory, and information retrieval, to name a few. A fuzzy inference requires three parts: a membership function generation circuit that calculates the goodness of fit between an input value and the membership function of an antecedent part, a minimum value operation circuit that finds an inference result for each rule, and a maximum value operation circuit that integrates a plurality of inference results. When these components are combined into a system, the system can do inference. Each externally supplied input value, this membership function generating circuit creates one membership function value. The decision-making logic of the fuzzy inference machine is crucial, and it may be the system’s most adaptive component. The fuzzification interface corresponds to our sensory organs (e.g., eye, ear), the de-fuzzification interface to our action organs (e.g., arms, feet, etc.), the fuzzy rule base to our memory, and the fuzzy inference machine to our thought process when a fuzzy system is compared to a human controller. It is called a fuzzy expert system when an expert system uses fuzzy data to reason. It is important to know what makes up a fuzzy expert system. The fuzzy expert system consists of a fuzzy knowledge base (based on fuzzy rules), an interference engine, a working memory subsystem, an explanation subsystem, natural language interference, and knowledge acquisition.
The number of individuals visiting hospitals has grown in recent decades as a result of population expansion and changing lifestyles throughout the world. As a result, the medicare healthcare system is overburdened. On the other hand, for the old, crippled, underprivileged, or those who live far away, visiting the hospital is quite tough. As a consequence, their health may worsen to the point where they die. The Internet has now become a necessary component of our daily life. Education, finance, business, industry, entertainment, social networking, retail, and e-commerce are just a few of the uses of the internet. The IoT is the web’s next big thing (IoT). As a consequence, remote healthcare solutions were created to meet the medicare health system’s above-mentioned difficult challenges. The patient’s vital signs are monitored by electronic sensors and communicated to the hospital server through the Internet, allowing the doctor to examine, diagnose, and prescribe the required medicine to treat the patient without the patient needing to visit the hospital.
IntechOpen implements a robust policy to minimize and deal with instances of fraud or misconduct. As part of our general commitment to transparency and openness, and in order to maintain high scientific standards, we have a well-defined editorial policy regarding Retractions and Corrections.
",metaTitle:"Retraction and Correction Policy",metaDescription:"Retraction and Correction Policy",metaKeywords:null,canonicalURL:"/page/retraction-and-correction-policy",contentRaw:'[{"type":"htmlEditorComponent","content":"IntechOpen’s Retraction and Correction Policy has been developed in accordance with the Committee on Publication Ethics (COPE) publication guidelines relating to scientific misconduct and research ethics:
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\n\n1. RETRACTIONS
\n\nA Retraction of a Chapter will be issued by the Academic Editor, either following an Author’s request to do so or when there is a 3rd party report of scientific misconduct. Upon receipt of a report by a 3rd party, the Academic Editor will investigate any allegations of scientific misconduct, working in cooperation with the Author(s) and their institution(s).
\n\nA formal Retraction will be issued when there is clear and conclusive evidence of any of the following:
\n\nPublishing of a Retraction Notice will adhere to the following guidelines:
\n\n1.2. REMOVALS AND CANCELLATIONS
\n\n2. STATEMENTS OF CONCERN
\n\nA Statement of Concern detailing alleged misconduct will be issued by the Academic Editor or publisher following a 3rd party report of scientific misconduct when:
\n\nIntechOpen believes that the number of occasions on which a Statement of Concern is issued will be very few in number. In all cases when such a decision has been taken by the Academic Editor the decision will be reviewed by another editor to whom the author can make representations.
\n\n3. CORRECTIONS
\n\nA Correction will be issued by the Academic Editor when:
\n\n3.1. ERRATUM
\n\nAn Erratum will be issued by the Academic Editor when it is determined that a mistake in a Chapter originates from the production process handled by the publisher.
\n\nA published Erratum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n3.2. CORRIGENDUM
\n\nA Corrigendum will be issued by the Academic Editor when it is determined that a mistake in a Chapter is a result of an Author’s miscalculation or oversight. A published Corrigendum will adhere to the Retraction Notice publishing guidelines outlined above.
\n\n4. FINAL REMARKS
\n\nIntechOpen wishes to emphasize that the final decision on whether a Retraction, Statement of Concern, or a Correction will be issued rests with the Academic Editor. The publisher is obliged to act upon any reports of scientific misconduct in its publications and to make a reasonable effort to facilitate any subsequent investigation of such claims.
\n\nIn the case of Retraction or removal of the Work, the publisher will be under no obligation to refund the APC.
\n\nThe general principles set out above apply to Retractions and Corrections issued in all IntechOpen publications.
\n\nAny suggestions or comments on this Policy are welcome and may be sent to permissions@intechopen.com.
\n\nPolicy last updated: 2017-09-11
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This overview of recent technological advances, discussion of pertinent problems and prospect of current methodologies in the separation of bioactive natural products may provide a driving force for the development of novel separation techniques.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Siti Zullaikah, Orchidea Rachmaniah, Adi Tjipto Utomo, Helda\nNiawanti and Yi Hsu Ju",authors:[{id:"190944",title:"Ph.D.",name:"Siti",middleName:null,surname:"Zullaikah",slug:"siti-zullaikah",fullName:"Siti Zullaikah"},{id:"191020",title:"Dr.",name:"Adi",middleName:null,surname:"Utomo",slug:"adi-utomo",fullName:"Adi Utomo"},{id:"191021",title:"Prof.",name:"Yi Hsu",middleName:null,surname:"Ju",slug:"yi-hsu-ju",fullName:"Yi Hsu Ju"},{id:"207289",title:"MSc.",name:"Orchidea",middleName:null,surname:"Rachmaniah",slug:"orchidea-rachmaniah",fullName:"Orchidea Rachmaniah"},{id:"220747",title:"MSc.",name:"Helda",middleName:null,surname:"Niawanti",slug:"helda-niawanti",fullName:"Helda Niawanti"}]},{id:"56734",doi:"10.5772/intechopen.70421",title:"Ionic Liquids as Green Corrosion Inhibitors for Industrial Metals and Alloys",slug:"ionic-liquids-as-green-corrosion-inhibitors-for-industrial-metals-and-alloys",totalDownloads:2166,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Present chapter describes recent advances in the field of development of ionic liquids as green and sustainable corrosion inhibitors for metals and alloys. The present chapter has been divided into several sections and subsections. Recently, development of the green and sustainable technologies for the corrosion prevention is highly desirable due to increasing ecological awareness and strict environmental regulations. In the last two decades, corrosion inhibition using ionic liquids has attracted considerable attention due to its interesting properties such as low volatility, non-inflammability, non-toxic nature, high thermal and chemical stability and high adorability. Several types of ionic liquids have been developed as “green corrosion inhibitors” for different metals and alloys such as mild steel, aluminum, copper, zinc, and magnesium in several electrolytic media. The ionic liquids are promising, noble, green and sustainable candidates to replace the traditional volatile corrosion inhibitors.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Chandrabhan Verma, Eno E. Ebenso and Mumtaz Ahmad Quraishi",authors:[{id:"35005",title:"Prof.",name:"Eno",middleName:null,surname:"Ebenso",slug:"eno-ebenso",fullName:"Eno Ebenso"},{id:"207838",title:"Prof.",name:"Mumtaz",middleName:null,surname:"Quraishi",slug:"mumtaz-quraishi",fullName:"Mumtaz Quraishi"},{id:"215227",title:"Dr.",name:"Chandrabhan",middleName:null,surname:"Verma",slug:"chandrabhan-verma",fullName:"Chandrabhan Verma"}]},{id:"49733",doi:"10.5772/62079",title:"Breakthroughs in Indole and Indolizine Chemistry – New Synthetic Pathways, New Applications",slug:"breakthroughs-in-indole-and-indolizine-chemistry-new-synthetic-pathways-new-applications",totalDownloads:2699,totalCrossrefCites:4,totalDimensionsCites:8,abstract:"Indole and indolizines (heterocyclic aromatic compounds structurally and chemically isomeric with indoles) are an important class of N-fused heterocyclic compounds due to their interesting biological and optical properties. Different strategies for generating diverse collections of small molecules with indole and indolizine moieties have been developed. They can be synthesized by means of classical and nonclassical pathways. The present study discusses the versatile nature of indole/indolizine derivatives, new green methods for their synthesis, their possible mechanism of action and also provides information about current/future prospects of the topics and different indole/indolizine derivatives in pharmaceutical/clinical trials. With the remarkable number of approved indole-containing drugs as well as the importance of the indolizine moiety, it can be easily concluded that indole and indolizine derivatives offer perspectives on how pyrrole scaffolds might be exploited in the future as bioactive molecules against a broad range of diseases.",book:{id:"5108",slug:"scope-of-selective-heterocycles-from-organic-and-pharmaceutical-perspective",title:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective",fullTitle:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective"},signatures:"Ioana Otilia Ghinea and Rodica Mihaela Dinica",authors:[{id:"177239",title:"Prof.",name:"Rodica Mihaela",middleName:null,surname:"Dinica",slug:"rodica-mihaela-dinica",fullName:"Rodica Mihaela Dinica"},{id:"177240",title:"Dr.",name:"Ioana Otilia",middleName:null,surname:"Ghinea",slug:"ioana-otilia-ghinea",fullName:"Ioana Otilia Ghinea"}]}],mostDownloadedChaptersLast30Days:[{id:"57200",title:"Introductory Chapter: Principles of Green Chemistry",slug:"introductory-chapter-principles-of-green-chemistry",totalDownloads:2817,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Hosam El-Din Mostafa Saleh and M. Koller",authors:[{id:"144691",title:"Prof.",name:"Hosam M.",middleName:null,surname:"Saleh",slug:"hosam-m.-saleh",fullName:"Hosam M. Saleh"},{id:"218817",title:"Dr.",name:"Martin",middleName:null,surname:"Koller",slug:"martin-koller",fullName:"Martin Koller"}]},{id:"56734",title:"Ionic Liquids as Green Corrosion Inhibitors for Industrial Metals and Alloys",slug:"ionic-liquids-as-green-corrosion-inhibitors-for-industrial-metals-and-alloys",totalDownloads:2165,totalCrossrefCites:7,totalDimensionsCites:11,abstract:"Present chapter describes recent advances in the field of development of ionic liquids as green and sustainable corrosion inhibitors for metals and alloys. The present chapter has been divided into several sections and subsections. Recently, development of the green and sustainable technologies for the corrosion prevention is highly desirable due to increasing ecological awareness and strict environmental regulations. In the last two decades, corrosion inhibition using ionic liquids has attracted considerable attention due to its interesting properties such as low volatility, non-inflammability, non-toxic nature, high thermal and chemical stability and high adorability. Several types of ionic liquids have been developed as “green corrosion inhibitors” for different metals and alloys such as mild steel, aluminum, copper, zinc, and magnesium in several electrolytic media. The ionic liquids are promising, noble, green and sustainable candidates to replace the traditional volatile corrosion inhibitors.",book:{id:"6067",slug:"green-chemistry",title:"Green Chemistry",fullTitle:"Green Chemistry"},signatures:"Chandrabhan Verma, Eno E. Ebenso and Mumtaz Ahmad Quraishi",authors:[{id:"35005",title:"Prof.",name:"Eno",middleName:null,surname:"Ebenso",slug:"eno-ebenso",fullName:"Eno Ebenso"},{id:"207838",title:"Prof.",name:"Mumtaz",middleName:null,surname:"Quraishi",slug:"mumtaz-quraishi",fullName:"Mumtaz Quraishi"},{id:"215227",title:"Dr.",name:"Chandrabhan",middleName:null,surname:"Verma",slug:"chandrabhan-verma",fullName:"Chandrabhan Verma"}]},{id:"49951",title:"Significance of Thiazole-based Heterocycles for Bioactive Systems",slug:"significance-of-thiazole-based-heterocycles-for-bioactive-systems",totalDownloads:3634,totalCrossrefCites:6,totalDimensionsCites:13,abstract:"Monocyclic and Bicyclic aromatic heterocycles such as imidazoles, thiazoles, thiadiazoles, oxazoles, oxadiazoles quinazolines, indoles, benzimidazoles, purines pyrido[4,3-d]pyrimidines, thiazolo[5,4-d]pyrimidines, thiazolo[4,5-d]pyrimidines, oxazolo[5,4-d]pyrimidines and thieno[2,3-d]pyrimidines are renowned pharmacophores in drug discovery. These special structures are well explained and exemplified in chemical compound libraries. In this chapter, several types of thiazole based heterocyclic scaffolds such as monocyclic or bicyclic systems synthesis and their biological activities studies are presented, which are not frequently present in books and reviews. We mention the first importance of synthetic route of various thiazole based compounds and their applications in medicinal chemistry in this chapter.",book:{id:"5108",slug:"scope-of-selective-heterocycles-from-organic-and-pharmaceutical-perspective",title:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective",fullTitle:"Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective"},signatures:"Someshwar Pola",authors:[{id:"177037",title:"Dr.",name:"Someshwar",middleName:null,surname:"Pola",slug:"someshwar-pola",fullName:"Someshwar Pola"}]},{id:"51672",title:"Recent Advances in Sustainable Organocatalysis",slug:"recent-advances-in-sustainable-organocatalysis",totalDownloads:2698,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"The recent advances on green and sustainable organocatalysis are revised in this chapter. An important focus on one of the 12 principles of green chemistry, organocatalysis pursues to reduce energy consumption as well as to optimize the use of different resources, targeting to become a sustainable strategy in organic chemical transformations. In last decades, several experimental methodologies have been performed to make organocatalysis an even greener and sustainable alternative to stoichiometric approaches as well as non-catalytic conditions by the use of benign and friendlier reaction media. In this line, several approaches using water as preferential solvent, alternative solvents such as ionic liquids including chiral ones, deep eutectic solvents, polyethylene glycol (PEG), supercritical fluids and organic carbonates or solvent-free methodologies have been reported. In this chapter, we mainly focus on the recent remarkable advancements in organocatalysis using green and sustainable protocols.",book:{id:"5206",slug:"recent-advances-in-organocatalysis",title:"Recent Advances in Organocatalysis",fullTitle:"Recent Advances in Organocatalysis"},signatures:"Luis C. Branco, Ana M. Faisca Phillips, Maria M. Marques, Sandra\nGago and Paula S. Branco",authors:[{id:"18681",title:"Dr.",name:"Luis C.",middleName:null,surname:"Branco",slug:"luis-c.-branco",fullName:"Luis C. Branco"}]},{id:"50746",title:"Recent Advances in Guanidine-Based Organocatalysts in Stereoselective Organic Transformation Reactions",slug:"recent-advances-in-guanidine-based-organocatalysts-in-stereoselective-organic-transformation-reactio",totalDownloads:2296,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Tremendous efforts have been put toward the design and synthesis of newer enantioselective organocatalysts for the enanatioselective synthesis. Recently, guanidine-containing chiral organocatalysts have attracted considerable attention due to their ease of synthesis and high enantioselective catalytic activities. This chapter highlights the successive development of chiral guanidine organocatalysts in asymmetric organic transformation reactions in the past few decades.",book:{id:"5206",slug:"recent-advances-in-organocatalysis",title:"Recent Advances in Organocatalysis",fullTitle:"Recent Advances in Organocatalysis"},signatures:"Shrawan Kumar Mangawa and Satish Kumar Awasthi",authors:[{id:"173269",title:"Prof.",name:"Satish",middleName:null,surname:"Awasthi",slug:"satish-awasthi",fullName:"Satish Awasthi"},{id:"185375",title:"Dr.",name:"Shrawan",middleName:"Kumar",surname:"Mangawa",slug:"shrawan-mangawa",fullName:"Shrawan Mangawa"}]}],onlineFirstChaptersFilter:{topicId:"497",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"13",title:"Veterinary Medicine and Science",doi:"10.5772/intechopen.73681",issn:"2632-0517",scope:"Paralleling similar advances in the medical field, astounding advances occurred in Veterinary Medicine and Science in recent decades. These advances have helped foster better support for animal health, more humane animal production, and a better understanding of the physiology of endangered species to improve the assisted reproductive technologies or the pathogenesis of certain diseases, where animals can be used as models for human diseases (like cancer, degenerative diseases or fertility), and even as a guarantee of public health. Bridging Human, Animal, and Environmental health, the holistic and integrative “One Health” concept intimately associates the developments within those fields, projecting its advancements into practice. This book series aims to tackle various animal-related medicine and sciences fields, providing thematic volumes consisting of high-quality significant research directed to researchers and postgraduates. It aims to give us a glimpse into the new accomplishments in the Veterinary Medicine and Science field. 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After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:3,paginationItems:[{id:"19",title:"Animal Science",coverUrl:"https://cdn.intechopen.com/series_topics/covers/19.jpg",isOpenForSubmission:!0,editor:{id:"259298",title:"Dr.",name:"Edward",middleName:null,surname:"Narayan",slug:"edward-narayan",fullName:"Edward Narayan",profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",biography:"Dr. Edward Narayan graduated with Ph.D. degree in Biology from the University of the South Pacific and pioneered non-invasive reproductive and stress endocrinology tools for amphibians - the novel development and validation of non-invasive enzyme immunoassays for the evaluation of reproductive hormonal cycle and stress hormone responses to environmental stressors. \nDr. Narayan leads the Stress Lab (Comparative Physiology and Endocrinology) at the University of Queensland. A dynamic career research platform which is based on the thematic areas of comparative vertebrate physiology, stress endocrinology, reproductive endocrinology, animal health and welfare, and conservation biology. \nEdward has supervised 40 research students and published over 60 peer reviewed research.",institutionString:null,institution:{name:"University of Queensland",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},{id:"20",title:"Animal Nutrition",coverUrl:"https://cdn.intechopen.com/series_topics/covers/20.jpg",isOpenForSubmission:!0,editor:{id:"175967",title:"Dr.",name:"Manuel",middleName:null,surname:"Gonzalez Ronquillo",slug:"manuel-gonzalez-ronquillo",fullName:"Manuel Gonzalez Ronquillo",profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",biography:"Dr. Manuel González Ronquillo obtained his doctorate degree from the University of Zaragoza, Spain, in 2001. He is a research professor at the Faculty of Veterinary Medicine and Animal Husbandry, Autonomous University of the State of Mexico. He is also a level-2 researcher. He received a Fulbright-Garcia Robles fellowship for a postdoctoral stay at the US Dairy Forage Research Center, Madison, Wisconsin, USA in 2008–2009. He received grants from Alianza del Pacifico for a stay at the University of Magallanes, Chile, in 2014, and from Consejo Nacional de Ciencia y Tecnología (CONACyT) to work in the Food and Agriculture Organization’s Animal Production and Health Division (AGA), Rome, Italy, in 2014–2015. He has collaborated with researchers from different countries and published ninety-eight journal articles. He teaches various degree courses in zootechnics, sheep production, and agricultural sciences and natural resources.\n\nDr. Ronquillo’s research focuses on the evaluation of sustainable animal diets (StAnD), using native resources of the region, decreasing carbon footprint, and applying meta-analysis and mathematical models for a better understanding of animal production.",institutionString:null,institution:{name:"Universidad Autónoma del Estado de México",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null},{id:"28",title:"Animal Reproductive Biology and Technology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/28.jpg",isOpenForSubmission:!0,editor:{id:"177225",title:"Prof.",name:"Rosa Maria Lino Neto",middleName:null,surname:"Pereira",slug:"rosa-maria-lino-neto-pereira",fullName:"Rosa Maria Lino Neto Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9wkQAC/Profile_Picture_1624519982291",biography:"Rosa Maria Lino Neto Pereira (DVM, MsC, PhD and) is currently a researcher at the Genetic Resources and Biotechnology Unit of the National Institute of Agrarian and Veterinarian Research (INIAV, Portugal). She is the head of the Reproduction and Embryology Laboratories and was lecturer of Reproduction and Reproductive Biotechnologies at Veterinary Medicine Faculty. She has over 25 years of experience working in reproductive biology and biotechnology areas with a special emphasis on embryo and gamete cryopreservation, for research and animal genetic resources conservation, leading research projects with several peer-reviewed papers. Rosa Pereira is member of the ERFP-FAO Ex situ Working Group and of the Management Commission of the Portuguese Animal Germplasm Bank.",institutionString:"The National Institute for Agricultural and Veterinary Research. Portugal",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:20,paginationItems:[{id:"82991",title:"Diseases of the Canine Prostate Gland",doi:"10.5772/intechopen.105835",signatures:"Sabine Schäfer-Somi",slug:"diseases-of-the-canine-prostate-gland",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Recent Advances in Canine Medicine",coverURL:"https://cdn.intechopen.com/books/images_new/11580.jpg",subseries:{id:"19",title:"Animal Science"}}},{id:"82956",title:"Potential Substitutes of Antibiotics for Swine and Poultry Production",doi:"10.5772/intechopen.106081",signatures:"Ho Trung Thong, Le Nu Anh Thu and Ho Viet Duc",slug:"potential-substitutes-of-antibiotics-for-swine-and-poultry-production",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Antibiotics and Probiotics in Animal Food - Impact and Regulation",coverURL:"https://cdn.intechopen.com/books/images_new/11578.jpg",subseries:{id:"20",title:"Animal Nutrition"}}},{id:"82905",title:"A Review of Application Strategies and Efficacy of Probiotics in Pet Food",doi:"10.5772/intechopen.105829",signatures:"Heather Acuff and Charles G. 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She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"91",type:"subseries",title:"Sustainable Economy and Fair Society",keywords:"Sustainable, Society, Economy, Digitalization, KPIs, Decision Making, Business, Digital Footprint",scope:"\r\n\tGlobally, the ecological footprint is growing at a faster rate than GDP. This phenomenon has been studied by scientists for many years. However, clear strategies and actions are needed now more than ever. Every day, humanity, from individuals to businesses (public and private) and governments, are called to change their mindset in order to pursue a virtuous combination for sustainable development. Reasoning in a sustainable way entails, first and foremost, managing the available resources efficiently and strategically, whether they are natural, financial, human or relational. In this way, value is generated by contributing to the growth, improvement and socio-economic development of the communities and of all the players that make up its value chain. In the coming decades, we will need to be able to transition from a society in which economic well-being and health are measured by the growth of production and material consumption, to a society in which we live better while consuming less. In this context, digitization has the potential to disrupt processes, with significant implications for the environment and sustainable development. There are numerous challenges associated with sustainability and digitization, the need to consider new business models capable of extracting value, data ownership and sharing and integration, as well as collaboration across the entire supply chain of a product. In order to generate value, effectively developing a complex system based on sustainability principles is a challenge that requires a deep commitment to both technological factors, such as data and platforms, and human dimensions, such as trust and collaboration. Regular study, research and implementation must be part of the road to sustainable solutions. Consequently, this topic will analyze growth models and techniques aimed at achieving intergenerational equity in terms of economic, social and environmental well-being. It will also cover various subjects, including risk assessment in the context of sustainable economy and a just society.
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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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