In Russian Federation, 27,300,000–41,200,000 acute upper and lower respiratory infections are reported annually. Patients with chronic obstructive pulmonary disease (COPD) are at higher risk of severe course, complications, and lethal outcomes of influenza. About 30% of COPD exacerbations are due to viral infections, and influenza A and B viruses are among the most common causes. The aim of our study was to assess exacerbation rate, number of courses of antibiotic chemotherapy, pulmonary function, and immunological effects of mono-vaccination with a new immunoadjuvant influenza vaccine vs. combined vaccination against pneumococcal infection, Hemophilus type b infection, and influenza in COPD patients. Both complex vaccination against Streptococcus pneumoniae, Haemophilus influenzae type b, and influenza and mono-vaccination with a new immunoadjuvant influenza vaccine led to statistically significant reduction in the number of COPD exacerbations and of antibiotic chemotherapy courses. Based on the obtained results, widespread implementation of mono-vaccination against influenza with a new immunoadjuvant influenza vaccine, as well as complex vaccination against bacterial respiratory infections and influenza can be recommended for COPD patients, as vaccination is beneficial for their functional status, that is, improves forced expiratory volume in 1 s (FEV1) and 6-minute walk test results. In our study, we evaluated immunogenicity of the new influenza immunoadjuvant vaccine administered as mono-vaccine to COPD patients in accordance with Committee for Proprietary Medicinal Products (CPMP) requirements.
Part of the book: Steps Forwards in Diagnosing and Controlling Influenza
The study aims at evaluating the efficacy of combined administration of imiquimod 5% crème and human papillomavirus (HPV) quadrivalent recombinant vaccine in order to achieve a long‐term clinical remission in patients with chronic HPV infection manifested in condyloma accuminata (CA) of the anogenital area. The study enrolled 36 subjects aged 26.4 (4.1) years (including 22 men) with one to five condyloma accuminata of the anogenital area. Study participants were vaccinated with human papillomavirus quadrivalent recombinant vaccine using a 0–2–6‐month regimen with concomitant administration of imiquimod 5% crème applied three times per week for not more than 16 weeks. Patients were monitored over 2 years. Complete disappearance of condyloma accuminata was observed in 34 out of 36 subjects (94.4%) after 1 year from the start of treatment. Two patients still having condyloma accuminata of the anogenital area after 1 year of combination treatment underwent a successful course of treatment with Solcoderm (one patient for 1 year 3 months and the other for 1 year 4 months), which resulted in complete disappearance of condyloma accuminata. Within 2‐year period, no recurrence of condyloma accuminata of the anogenital area has been observed.
Part of the book: Vaccines
The aim of the work was to determine the clinical safety and immunogenicity of immunoadjuvant vaccines against influenza (MonoGripol Plus and Grippol® Plus) in 182 pregnant women in the II and III trimesters of gestation, and further assessment of fetal conditions and infants of the first 6 months of life. Results: It was shown that immunoadjuvant vaccines do not have a negative effect on the physiological course of pregnancy and the functional state of the fetoplacental complex. In the early postpartum period, the rates of physical and neuro-psychological development and the nature of feeding of children did not differ from the control group. In pregnant women vaccinated with Grippol® plus, the levels of seroprotection to strains of A/H1N1/v are 82.0%, A/H3N2/—88.0%, B—88.3% that measure the CPMP criteria and last more than a year . After birth, transplacental antibodies in children in protective values were observed in 52.3–68.9% of cases, did not differ from the control group, and disappear after 6 months. Respiratory infections during the first 6 months of life of infants born from mothers vaccinated against influenza registered in 1.8 times less frequently.
Part of the book: Vaccines