Guy-Joseph Lemamy

University of Health Sciences

Guy Joseph Lemamy, PhD, is currently General Manager of High Institute of Medical Biology at University of Health Sciences, in Libreville, Gabon (Institut Supérieur de Biologie Médicale de L'Université des Sciences de la Santé) Professor at the Department of Cellular and Molecular Biology-Genetics, he also leads the Laboratory of Cellular and Molecular Pathobiology. Dr Lemamy obtained his PhD in Biochemistry and Cell Biology at the Faculty of Medicine, Université Montpellier, France. His PhD thesis concerned the research for new tumor markers in breast cancer led by Medical Research Institute (INSERM U148) in Montpellier, France. Dr Lemamy is the author of many book chapters and journal articles about tumor markers and is involved in other scientific activities in his country Gabon. He is a Member of Scientific Advisory Board of Gabon Scientific Research Guiding Plan and CHEVALIER DES PALMES ACADEMIQUES of International Order of Academic Palms of African and Malagasy Council for Higher Education.

2books edited

2chapters authored

Latest work with IntechOpen by Guy-Joseph Lemamy

Cancer is a malignant tumor caused by DNA damage, which leads to uncontrolled cell growth. Tumor progression is locally favored by the mitogenic effects of hormones or growth factors, which stimulate the tumor's growth, or the activation of vascular endothelial growth factor receptor, which induces angiogenesis and leads to metastasis. About 300 out of 25,000 genes that set up the human genome are involved in cancer pathology. These genes are divided into three groups: oncogenes, tumor suppressor genes, and DNA repair genes. Activated oncogenes promote the development of cancer, whereas the tumor suppressor and DNA repair genes have a protective role by respectively inhibiting cell cycle progression and inducing apoptosis, or by repairing DNA damage occurring during the cell cycle. This book discusses the issue of tumor suppressor genes through chapters written by experts using advanced biochemistry, cell, and molecular biology tools. The tumor suppressor genes can be used as markers of risk to identify populations with high risk or targets for cancer treatment and therapeutic resistance. We hope that the work provided in this book will be useful for researchers and students and will increase knowledge of the understanding of cancer and improve its treatment.

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