JAK-STAT signalling is a main transduction pathway of cytokines and growth factors, which is involved in several biological processes including cell proliferation, cell differentiation, axon regeneration, apoptosis and inflammation. After spinal cord injury several cytokines activate the JAK-STAT pathway, thereby modulating several cell responses. In this chapter we discuss how regulation of this signalling pathway could improve motor recovery after injury by modulation of axon regeneration, neuroprotection, glial scar formation, demyelination and inflammatory response. Studies with gene over-expression, gene deletion and in vitro approaches will be discussed for understanding the cell-specific response to JAK-STAT signalling, with a focus on preclinical treatment with IL6-family cytokines, hematopoietic cytokines and IL10.
Part of the book: Recovery of Motor Function Following Spinal Cord Injury