Nikolai Gorbunov

Dr. Nikolai V. Gorbunov received his PhD degree in biology from the Russian Academy Sciences. Then he was granted with a postdoctoral research award by the NRC (NAS) Research Associateship Programs and joined the Walter Reed Army Institute of Research (http://wrair-www.army.mil) to pursue postdoctoral training and research on biophysics and molecular and cellular pathology of blast-related polytrauma. Later Dr. N.V. Gorbunov accomplished a DoE-sponsored training in radiation sciences and radiation health at the University of Pittsburgh and the Pacific Northwest National Laboratory (https://www.emsl.pnl.gov/emslweb; Washington, USA). His translational research areas have encompassed redox homeostasis and systems biology of the blast polytrauma and radiation combined injury. In this framework, he investigated molecular and cellular mechanisms mediating the parenchymal and vascular interactions in the pathogenesis of dose-sensitive tissues focusing on development of new remedies for managements of the diseases [explored at WRAIR and the Uniformed Services University of the Health Sciences (https://www.usuhs.edu)].

2books edited

2chapters authored

Latest work with IntechOpen by Nikolai Gorbunov

Autophagy in Current Trends in Cellular Physiology and Pathology is addressed to one of the fundamental molecular mechanisms - autophagy- evolutionarily adopted by cells for processing of unnecessary or malfunctioned constituents and shaping intracellular structures, adjusting them to environmental conditions, aging, disease, neoplasia, and damages over their life period. Particular attention is paid to autophagy-mediated barrier processes of selective sequestration and recycling of impaired organelles and degradation of invading microorganisms, that is, the processes sustaining intrinsic resistance to stress, tissue degeneration, toxic exposures, and infections. The presented topics encompass personal experience and visions of the chapter contributors and the editors; the book chapters include a broad analysis of literature on biology of autophagy.

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