Amyloidosis comprises a group of protein-folding disorders in which extracellular deposits share unique Congo red staining properties and fibrillary ultrastructural appearance. These fibrillary deposits ultimately cause tissue destruction and progressive disease. Amyloidosis can be either systemic affecting multiple organs or localized. Renal involvement by amyloidosis (amyloid nephropathy) is a frequent manifestation of systemic amyloidosis. Immunofluorescence, immunohistochemistry (IHC), and more recently laser microdissection and mass spectrometry (LMD/MS) are important techniques in typing of amyloid nephropathy. This in-depth review discusses practical diagnostic approach and pathogenesis of amyloid nephropathy and includes discussion of treatment and prognosis.
Part of the book: Exploring New Findings on Amyloidosis