180° Peel adhesion (N/cm) from float glass for curved OLED display OCAs after varying dwell times.
\r\n\tIn sum, the book presents a reflective analysis of the pedagogical hubs for a changing world, considering the most fundamental areas of the current contingencies in education.
",isbn:"978-1-83968-793-8",printIsbn:"978-1-83968-792-1",pdfIsbn:"978-1-83968-794-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"b01f9136149277b7e4cbc1e52bce78ec",bookSignature:"Dr. María Jose Hernandez-Serrano",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/10229.jpg",keywords:"Teacher Digital Competences, Flipped Learning, Online Resources Design, Neuroscientific Literacy (Myths), Emotions and Learning, Multisensory Stimulation, Citizen Skills, Violence Prevention, Moral Development, Universal Design for Learning, Sensitizing on Diversity, Supportive Strategies",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 14th 2020",dateEndSecondStepPublish:"October 12th 2020",dateEndThirdStepPublish:"December 11th 2020",dateEndFourthStepPublish:"March 1st 2021",dateEndFifthStepPublish:"April 30th 2021",remainingDaysToSecondStep:"3 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Phil. Maria Jose Hernandez Serrano is a tenured lecturer in the Department of Theory and History of Education at the University of Salamanca, where she currently teaches on Teacher Education. She graduated in Social Education (2000) and Psycho-Pedagogy (2003) at the University of Salamanca. Then, she obtained her European Ph.D. in Education and Training in Virtual Environments by research with the University of Manchester, UK (2009).",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"187893",title:"Dr.",name:"María Jose",middleName:null,surname:"Hernandez-Serrano",slug:"maria-jose-hernandez-serrano",fullName:"María Jose Hernandez-Serrano",profilePictureURL:"https://mts.intechopen.com/storage/users/187893/images/system/187893.jpg",biography:"DPhil Maria Jose Hernandez Serrano is a tenured Lecturer in the Department of Theory and History of Education at the University of Salamanca (Spain), where she currently teaches on Teacher Education. She graduated in Social Education (2000) and Psycho-Pedagogy (2003) at the University of Salamanca. Then, she obtained her European Ph.D. on Education and Training in Virtual Environments by research with the University of Manchester, UK (2009). She obtained a Visiting Scholar Postdoctoral Grant (of the British Academy, UK) at the Oxford Internet Institute of the University of Oxford (2011) and was granted with a postdoctoral research (in 2021) at London Birbeck University.\n \nShe is author of more than 20 research papers, and more than 35 book chapters (H Index 10). She is interested in the study of the educational process and the analysis of cognitive and affective processes in the context of neuroeducation and neurotechnologies, along with the study of social contingencies affecting the educational institutions and requiring new skills for educators.\n\nHer publications are mainly of the educational process mediated by technologies and digital competences. Currently, her new research interests are: the transdisciplinary application of the brain-based research to the educational context and virtual environments, and the neuropedagogical implications of the technologies on the development of the brain in younger students. Also, she is interested in the promotion of creative and critical uses of digital technologies, the emerging uses of social media and transmedia, and the informal learning through technologies.\n\nShe is a member of several research Networks and Scientific Committees in international journals on Educational Technologies and Educommunication, and collaborates as a reviewer in several prestigious journals (see public profile in Publons).\n\nUntil March 2010 she was in charge of the Adult University of Salamanca, by coordinating teaching activities of more than a thousand adult students. She currently is, since 2014, the Secretary of the Department of Theory and History of Education. Since 2015 she collaborates with the Council Educational Program by training teachers and families in the translation of advances from educational neuroscience.",institutionString:"University of Salamanca",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Salamanca",institutionURL:null,country:{name:"Spain"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"23",title:"Social Sciences",slug:"social-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"301331",firstName:"Mia",lastName:"Vulovic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/301331/images/8498_n.jpg",email:"mia.v@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6942",title:"Global Social Work",subtitle:"Cutting Edge Issues and Critical Reflections",isOpenForSubmission:!1,hash:"222c8a66edfc7a4a6537af7565bcb3de",slug:"global-social-work-cutting-edge-issues-and-critical-reflections",bookSignature:"Bala Raju Nikku",coverURL:"https://cdn.intechopen.com/books/images_new/6942.jpg",editedByType:"Edited by",editors:[{id:"263576",title:"Dr.",name:"Bala",surname:"Nikku",slug:"bala-nikku",fullName:"Bala Nikku"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophanides",surname:"Theophile",slug:"theophanides-theophile",fullName:"Theophanides Theophile"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"878",title:"Phytochemicals",subtitle:"A Global Perspective of Their Role in Nutrition and Health",isOpenForSubmission:!1,hash:"ec77671f63975ef2d16192897deb6835",slug:"phytochemicals-a-global-perspective-of-their-role-in-nutrition-and-health",bookSignature:"Venketeshwer Rao",coverURL:"https://cdn.intechopen.com/books/images_new/878.jpg",editedByType:"Edited by",editors:[{id:"82663",title:"Dr.",name:"Venketeshwer",surname:"Rao",slug:"venketeshwer-rao",fullName:"Venketeshwer Rao"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4816",title:"Face Recognition",subtitle:null,isOpenForSubmission:!1,hash:"146063b5359146b7718ea86bad47c8eb",slug:"face_recognition",bookSignature:"Kresimir Delac and Mislav Grgic",coverURL:"https://cdn.intechopen.com/books/images_new/4816.jpg",editedByType:"Edited by",editors:[{id:"528",title:"Dr.",name:"Kresimir",surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"49462",title:"Utility of Potent Anti-viral MicroRNAs in Emerging Infectious Diseases",doi:"10.5772/61687",slug:"utility-of-potent-anti-viral-micrornas-in-emerging-infectious-diseases",body:'Since the HIV-1 pandemic of the 1980s and more recent outbreaks of bird flu, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome-Corona Virus (MER-CoV), it has been widely believed that there would be new pandemics of highly pathogenic viruses [1]. Fortunately, until recently, many of the new emerging pathogenic agents, such as Ebola virus (EBOV) and Marburg virus (MARV), have failed to demonstrate the transmissibility or animal reservoirs required to become true pandemic threats [2, 3]. Few, if any, antivirals can claim to be specific enough to halt the epidemic. Recently, a whole EBOV replication-defective vaccine—EBOVdVP30—has been found to be very effective in nonhuman primates, while two others are in Phase II trials [4].
The testing of the recently developed replication-defective recombinant chimpanzee adenovirus type 3–vectored ebolavirus (cAd3-EBO) vaccine is based on a demonstration of efficacy in a nonhuman primate model [5]. However, a curious finding has puzzled the investigators—preexisting neutralizing antibodies against cAd6 and cAd68 in human serum samples were found in ~40% of Ugandans and in 15% of the US and European volunteers. The increased prevalence of neutralizing antibodies against chimpanzee adenoviruses in sub-Saharan Africa may indicate cross-species transmission of these viruses from chimpanzees to humans. The possibility of fairly high levels of neutralizing antibodies against cAd3 may complicate the evaluation of the effectiveness of Ebola vaccines currently underway.
Filoviruses are taxonomically classified within the order Mononegavirales, a large group of enveloped viruses whose genomes are composed of a nonsegmented, single-stranded minus [2, 3] RNA molecule. Following their discovery, filoviruses were originally grouped with rhabdoviruses, as the appearance of these virus particles appeared similar [3]. However, subsequent filamentous morphology and extensive genetic, physiochemical, and virologic studies of Marburg virus (MARV) and Ebola virus (EBOV) revealed distinctive characteristics, and these viruses were placed into a separate family, the Filoviridae [3]. Further characterization of these agents demonstrated that EBOV and MARV represent divergent lineages of filoviruses, and that their variances were significant enough to warrant the formation of the two genera, MARV and EBOV [4]. Subsequent to the International Committee on Taxonomy of Viruses recommendation, the MARV genus contains a single species, the Lake Victoria Marburg virus, as this strain exhibits only limited genetic variation.
EBOV is the causative agent of Ebola virus disease (EVD) [6]. The mortality rate can vary from 40% to 93% depending on the strains [6]. The viral life cycle begins with host cell entry through a mechanism that is still poorly understood. The incubation period for EVD is 2–21 days, and typical early symptoms include fever, chills, malaise, and myalgia (all of which could be misdiagnosed as malaria, which is highly prevalent in West African nations), followed by the onset of symptoms indicative of multi-organ stress and subsequent failure, sometimes followed by hemorrhagic episodes that can easily be misdiagnosed as Lassa fever.
EBOV is a negative, single-stranded RNA virus with an unusual, variable-length, filamentous, branched morphology whose helical capsid is enclosed inside a membrane. The mechanism of attachment and entry into the cell is still not completely defined (see discussion below). Once inside, the viral RNA polymerase (L protein) begins to copy the negative strand (–ve) RNA to make the positive strand (+ve) transcripts that mimic the structure of mRNA and are translated by host ribosomes. Replication is thought to occur in the cytoplasm. An unusual feature of the transcription and translation of the Ebola genes is the fact that the glycoproteins (GP) are only expressed through transcriptional editing. The genome of the Zaire Ebola virus (EBOV), the most pathogenic among all species of EBOV, is 18,959 nucleotides (nts) in length and contains seven transcriptional units that guide synthesis of at least nine distinct primary translation products: the nucleoprotein (NP), virion protein (VP) 35, VP40, glycoprotein (GP), soluble glycoprotein (sGP), small soluble glycoprotein (ssGP), VP30, VP24, and the large (L) protein. L is the catalytic subunit of the viral polymerase complex (Figure 1). Similar to other nonsegmented negative-sense (NNS) RNA viruses, EBOVs encode a multiprotein complex to carry out replication and transcription. In the case of EBOV, viral RNA synthesis requires the viral NP, VP35, VP30, and L proteins. Transcription of filovirus mRNAs is presumed to occur as in other NNS viruses, where there is a gradient of viral mRNAs with the abundance of each mRNA transcript decreasing as the polymerase transcribes toward the 5′ end of the template [7]. Each EBOV mRNA is presumed to be efficiently modified with a 5′–7’-methylguanosine (m7G) cap and a 3′p (A) tail [8].
The genome of EBOV, 18 9 kb in length, has the following gene order: 3′ leader nucleoprotein (NP), virion proteins (VP) VP35-VP40, membrane glycoprotein (GP), viral polymerase (VP) VP30-VP24, viral polymerase L protein, and 5′ trailer.
The Ebola virus genus possesses greater diversity, and four viral species have been recognized: Zaire Ebola, Sudan Ebola, Reston Ebola, and Ivory Coast Ebola (EBOV-Z, EBOV-S, EBOV-R, and EBOV-IC, respectively). Each of the EBOV species has a different degree of pathogenicity and mortality rate [9]. Therefore, EBOV-S and EBOV-Z, which are the predominant EBOVs associated with known outbreaks, are more pathogenic than EBOV-R and EBOV-IC [10]. EBOV-IC has only caused a single nonfatal human infection, but EBOV-R has caused fatal infection in nonhuman primates [8]. However, EBOV-S, EBOV-Z, and EBOV-B often cause severe hemorrhagic diseases with markedly high case fatality rates (40–90%) [10]. The EBOV genome is 18.9 kb in length with the following gene order: 3′ leader nucleoprotein (NP), virion protein (VP) 35-VP40, glycoprotein (GP), VP30, VP24, polymerase (L), and 5′ trailer. The GP differences between any two species range from 37% to 41% at the nucleotide level and from 34% to 43% at the amino acid level [40]. However, variations within EBOV-Z species are very low (∼2–3%) [11]. Thus, GP nucleotides are usually used in the phylogenetic analysis of EBOV (Figure 2).
The Ebola Pandemic Map depicts the history of Ebola in Africa. The sporadic cases of Ebola were common in the central African countries such as the DRC (988 cases with 767 fatalities), Uganda (606 cases with 283 fatalities), South Sudan (335 cases with 180 fatalities), Gabon (214 cases with 150 fatalities), the Republic of the Congo (248 cases with 210 fatalities), and South Africa (2 cases with 1 fatality).
Because of their high mortality rate, which can vary from 40% to 93%, and their potential for person-to-person transmission and lack of an approved vaccine or antiviral therapy, MARV and EBOV are classified as biosafety level 4 (BSL-4) viruses by World Health Organization [12, 13]
Viruses are obligate intracellular parasites and essentially rely on host cells for raw materials, replication, transcription, and translations of their genetic codes. Until a few years ago, we assumed that the major intracellular defenses against viral pathogens were interferons [13]. Since the discovery of RNA interference (RNAi) and miRNAs, we know that one of the fundamental functions of miRNAs is to prevent replication of foreign viruses by pre- and posttranscriptions and suppressions of viral expression [12]. Therefore, besides endogenous gene regulation, miRNAs are the primary intracellular immune defense system [13]. Viruses have also evolved to counter the antiviral effects of miRNAs by viral miRNAs (vmiRNAs).
Recently, Li and Chen [14] have conducted molecular epidemiologic analyses of presently extant Ebola viral genomes to ascertain their evolutionary viral history. Of considerable potential importance are interpretations derived from a dataset that is between 1,000 and 2,100 years old and includes four Ebola species (EBOV-Z, EBOV-S, EBOV-TF, EBOV-R) [15]. Logically, one could assume that over the past 2,000 years, humans have evolved countermeasures to the Ebola virus via innate, adaptive, and miRNA-based immunity. The identification in a human database of 71 miRNAs capable of potentially quelling EBOV strongly suggests that Homo sapiens already have developed primary intracellular defenses to quell EBOV infection [16]. This raises a question: Why have EBOVs been circulating for about 2,000 years, and yet they seem to have emerged only recently? The earliest known cases of Ebola date to the 1970s. One theory proposes that EBOV-Z experienced a recent genetic bottleneck [17]. Before Ebola viral strains were introduced to primates, they had already been circulating among small mammals, including bats, rodents, marsupials, shrews, and so on [16]. Although these bats and other animals were infected [15, 16], no evidence demonstrated that such infections were fatal to them [18]. This indicates that a natural balance had been achieved between the viruses’ pathogenicity and the host’s immune system, especially at the intracellular levels where miRNAs provide immunological protection [19]. This homeostasis, this balance, apparently was broken in 1900, when EBOV genetic diversity experienced a dramatic drop [16]. Accordingly, most lineages of the various EBOV species became extinct because of such influences as threatening human activities, climate change, and a steep decline in the number of animals to serve as a reservoir for viral replication. Probably due to altered patterns of positive selection in the glycoprotein (GP), which diversified substantially and was found to be part of fusion and receptor binding within cellular membranes, infection patterns through direct exposure were changing. Therefore, by about 1970, few lineages that possessed broader tropism and enhanced fitness had the capacity to infect primates via direct exposure [16]. Similar examples can be seen in the emergence of HIV-1, which appeared to have surfaced in the 1950s through a zoonotic event that involved common infections among chimpanzees (i.e., SIV) and then accidentally jumped to humans [16–18]. Due to the paucity of significant differences in EBOV genetic diversity since 1970, the decreased number of surviving viruses may have become the only circulating lineages in primates and viral reservoirs. EBOV-Z has the ability to traverse a long distance through bats, which serve as a migratory reservoir. Outbreaks with their epicenter in Congo have been caused by the EBOV-Z species [20–23].
Through analysis of miRNA numbers that demonstrate high homologies in seed sequences and that show high identity to EBOV species, we have deduced that the genetic variations at the GP may serve as a type of Achilles’ heel. After all, only one miRNA showed identity to GP, while eight proved capable of blocking polymerase steps. This indicates that minor variations within the GP amino acid sequence could allow for viral entrance into host target cells in humans. The subsequent transcription of negative-stranded RNA viruses into positive RNA strands occurs amid a struggle to overcome the miRNAs with quelling potential that can halt this process. It is possible that at the time of exposure to EBOV, all of the protective miRNAs may not be present in the target cells, or may be present, but not in sufficient quantities to block early EBOV replication [24].
The illustration depicts a simplified structure of Ebola virus. The functions of various viral proteins are described in the text. GP, glycoprotein; NP, nucleoprotein; VP40, matrix protein; VP30, transcription factor; and polymerase enzyme.
Figure 3 shows the VP24, VP30, VP35, VP40, and L nucleoproteins that constitute the nucleocapsid, which is crucial in both the transcription and viral replication processes [25, 26]. The glycoprotein is located in the lipid membrane of the Ebola virus; this is also the place in the host target cells where receptors that facilitate viral entry are embedded [27]. Viral matrix proteins VP40 and VP24 are essential to viral budding, stability, and structure. VP40 is the primary matrix protein, and is the viral protein that is expressed most abundantly. It plays a central role in the process of Ebola budding from the plasma membrane. For example, in mammalian cells, the mere expression of VP40 is sufficient to create virus-like particles (VLPs) with morphological characteristics that are similar to those of the actual Ebola virus [28, 29]. Given VP40’s absence, studies have found that the nucleocapsid was not transported effectively into the plasma membrane, and as this membrane is the site of assembly, budding, and incorporation into the virions, considerable attention should be given to the role of this matrix protein [30]. The utilization of miRNAs that specifically target VP40 mRNA degradation is important to our understanding of just how VP40 functions and what potential roles it might play in the regulation of VLP assembly in both in vitro and live cell settings. hsa-miR-4692 and hsa-miR-548-az effectively target VP40; therefore, the overexpression of these particular miRNAs within host cells could totally disrupt the viral life cycle and may have a decisive impact in the categorization of therapeutic targets (data unpublished). The tendency of Ebola VP40 to assemble virus-like particles (VLPs) presents an appealing model for analysis of the Ebola viral assembly at biosafety level 2 made possible by the noninfectious nature of genetically engineered VLPs [31].
VP40’s association with the plasma membrane is of fundamental importance [30]; it is here that assembly is initiated as well as oligomerization [31], and nucleoprotein recruitment. Besides membrane association, VP40 also associates or otherwise interacts with host cell factors, including the endosomal sorting complex that supports transport (ESCRT) machinery [27, 29], the vesicle coat II proteins (COPII) [24], as well as the protein actin [25, 30]; these host cell factors, respectively, have been shown to enable VP40 budding, transport, and movement. Moreover, host cell protein kinases could contribute to Ebola infectivity as c-Abl1 can phosphorylate Tyr13 in VP40 [32, 33]. Still we have an inadequate understanding of how VP40 actually assembles on the plasma membrane before virion release occurs. Localization of VP40 in the plasma membrane is believed to be important as studies give evidence that hydrophobic residues located within the C-terminal domain, including Leu213, are essential in the localization and budding processes [32]. Detection of VP40 oligomers in VLPs and UV-inactivated virions has occurred [34, 35]; they have been detected mainly in filamentous structures stemming from the plasma membrane [36]. Therefore, VP40 oligomerization apparently occurs on the same plasma membrane in which oligomers selectively have found to reside [37]. In terms of structure, VP40 has predominantly been found to oligomerize into either hexamers or octamers [38, 39]. These share a comparable monomer–monomer (or intradimeric) antiparallel interface. However, the detection of oligomeric structures in live cells suggests that these structures, too, could exert a critical influence on both viral assembly and egress [40]. We discovered that hsa-miR-4692 and hsa-miR-548-az both target VP40 (data unpublished).
The formation of virus-like particles (VLPs) requires VP40 oligomers; these are associated with membranes that are resistant to detergent [41], which underscores the active part that the plasma membrane may play in VP40 oligomerization. Moreover, on the plasma membrane, matrix protein oligomerization may function as a scaffold in host protein recruitment, and also supply the force needed to effect the formation of virus particles and the deformation of membranes. A comprehension of VP40 plasma membrane association thus becomes crucial to our understanding of how the formation of protein buds occurs on the plasma membrane. Gupta K [42] recently investigated the role that the VP40 C-terminal domain plays in membrane association as well as in membrane penetration. These investigators utilized the monolayer penetration methodology to conduct in vitro research into the molecular basis of the penetration of the VP40 membrane. To study VP40 assembly and its associated egress in cells, they employed a multipronged methodology that blended cellular imaging, number and brightness (N&B) analysis, analysis of the egress of virus-like particles, site-directed mutagenesis, and total internal reflection (TIRF) microscopy. N&B analysis permitted them to ascertain the average number of molecules and also the brightness within each pixel within a fluorescence microscopy image. This permitted them to detect the oligomeric status of proteins that are labeled fluorescently. They concluded that within the VP40 C-terminal domain, a hydrophobic interface actually penetrates the plasma membrane, which plays a key role in the oligomerization of VP40. The knocking out of plasma membrane penetration by hydrophobic mutants also substantially reduces the egress of VLPs [38, 39]. Therefore, degradation of VP40 mRNA by a two-pronged attack from hsa-miR-4692 and hsa-miR-548-az can stop Ebola.
A distinguishing characteristic of filovirus genomes is their 3′- and 5′-UTRs that are long related to other RNA viruses of the nonsegmented negative-strand (NNS) variety [40]. Of particular note, Kochetov AV [41] concentrated on the 5′-UTRs in the mRNA of seven EBOV viruses, due to the critical importance of the 5′-UTRs in translation initiation. In four of these seven mRNAs, small alternate upstream open reading frames (uORFs) were identified, but their significance is yet to be fully characterized. In cellular mRNAs, uORFs are known to be a common feature; they are critical in modulating translation of primary ORFs (pORFs), which was accomplish by reducing the efficiency and quantity of the scanning ribosomes associated with the reinitiation that occurs at the start codon of pORFs [42]. At a uAUG, rather than a pAUG, translation initiation frequency is affected by a variety of factors, including the strength of the Kozak consensus sequence that surrounds the uAUG. Moreover, between the pAUG and the upstream open reading frame (uORF) is an intercistronic space that, combined with the phosphorylation status of and the eIF-2α [43, 44], controls whether translation takes place at the principal protein initiation site (pAUG) or at the termination codon (uAUG).
When eIF-2α∼P is absent, cap-dependent translation has been found to be efficient, which permits higher ribosome initiation rates at the uORF [45]. When eIF2α∼P is enhanced, impairment of translation initiation occurs, which causes a ribosome to continue scanning beyond the uAUG; in this case, initiation occurs at the pAUG. In short, when cell stress occurs, eIF2α∼P facilitates translation initiation of select mRNAs that possess uORFs at the primary open ready frame (pORF) [46].
They characterized how the EBOV 5′-UTRs modulate translation. Mutating any of the four uAUGs present in the EBOV genome enhances translation at the corresponding pORF. The most dramatic effect was with the L gene where the L uAUG can potently suppress pORF translation; however, in response to eIF2α∼P, the L uAUG maintains L translation. Modulating viral polymerase levels is biologically significant as ablating the L uORF in a recombinant EBOV reduces viral titers 10- to 100-fold in cell culture, severely impairs viral RNA synthesis, and functions to maintain virus titers in cells treated with stress-inducing agents. These data suggest that a uORF in the EBOV L mRNA regulates polymerase expression in response to the status of the cellular innate immune response and is required for optimal virus replication.
It would be relatively easy to incorporate a combination of relevant miRNAs in a miRNA-expression vector to test the utility of these miRNAs in genetically engineered VLP cell models in vitro that can be performed in a BSL-2 facility, and then to extend these studies in animal models utilizing safe vectors in a BSL-4 environment.
Currently, there are several genetically engineered vaccines containing genes for surface proteins (GP) that are in clinical trial. The first among these is a vaccine that Ebola GP genes stitched into a weakened chimpanzee adenovirus that serves as a vector. The second vaccine contains the Ebola surface protein gene inside a weakened version of vesicular stomatitis virus (VSV), which commonly infects farm animals. The potential dangers of employing of VSV are obvious: it can save men but potentially harm livestock in West Africa. The chimpanzee adenovirus will be a zoonotic event itself, and its potential danger cannot be underestimated [47, 48].
The third vaccine uses a vector known as MVA, a modified version of the smallpox vaccine virus, and involves protection from an Ebola virus “challenge” 10 months after the last vaccination.
We noted that none of these three approaches mentioned a simple and well-tested method of human and animal vaccination. What happened to the simple, whole formalin-killed or UV-killed, less pathogenic EBOV vaccines that have been tried in so many viral vaccinations [49, 50]?
With viruses like the major Ebola strands, where the mortality rate is over 50%, it will be difficult to find a reasonable and ethical way to carry out an unbiased clinical trial. However, if one can prepare a “dead Ebola virus” with antigenicity intact, it would be easy to immunize “high risk groups” without utilizing unusual vectors as exemplified by “harmless” chimpanzee adenovirus, VSV or MVA (modified smallpox virus), each with unknown long-term risk factors and accompanied by immediate concerns of viral vector-induced antigenic competition that may potentially quell proper immune responses to the Ebola antigens [51]. We believe that a dead vaccine may induce the protective miRNAs and quell the pandemic. Increasingly, miRNA-induced intracellular immunity is being better understood, and several clinical trials are under way to treat viral diseases and cancers [52–55]. The cost of each of these vaccines would run into millions of dollars and would be prohibitively expensive to any of the individuals who are predicted to be infected with the virus in West African nations. In contrast to the proposed recombinant vaccines, each of the more traditional “killed vaccines” has been very inexpensive to produce and has benefited billions of humans [56].
The current ongoing Ebola outbreaks in West Africa that began almost three years ago in March 2013 have already claimed 11,000 lives and over 27,000 cases. The rapid spread of the infection demands the need for rapid prevention methods. Currently, there are several vaccines that are in different phases of clinical trials. In this report, we highlight an alternative to the standard vaccine for Ebola prevention. We show that a preventive method based on miRNAs could be utilized and tested in nonhuman primates. Some of the lessons that we have learned from the recent West Africa Ebola outbreaks is to test the vaccine and other preventive methods that are currently available against Ebola before the major outbreaks occur. Therefore, we recommend that vaccines and preventive methods must be developed to the point that the measures correlate for human protection (Phase I level), so when the outbreaks occur, the vaccine and other measures can be rolled out quickly to prevent the spread of the disease.
We would like to thank Dr. Donald Gene Pace for his editorial assistance.
Optically clear adhesives (OCA) and liquid optically clear adhesives (LOCA or OCR for optically clear resins) have been used in consumer electronics, industrial and automotive bonding solutions for more than 15 years. OCA usage increased significantly as consumer electronics devices saw the transition from resistive to capacitive touch with its first implementation in the LG Prada phone in 2006 [1]. The advantage of using an OCA shows improvements in mechanical, optical and electrical performance of the display module and device. The initial application in OCAs in rigid OLED-based devices was similar to LCD devices, but as plastic OLED (pOLED) devices were introduced to the market, OCAs enabled new form factors, such as curved OLEDs in the Galaxy Round and Galaxy Gear S [2] as well as the Galaxy Note Edge [3].
There are two important mechanical considerations for optically clear adhesives – does it stick (adhesive strength) and how strong is it (cohesive strength). Adhesive strength can be defined by the work of adhesion, which is the amount of work required to separate the adhesion from the adherend. Adhesion can be achieved through van der Waals interactions, hydrogen bonding, acid–base, ionic, covalent and mechanical interlocking [4, 5, 6]. Film based OCAs are pressure sensitive adhesives, while LOCAs are liquids that are dispensed and cured. Pressure sensitive adhesives exhibit tack when the modulus is below 3 × 105 Pa or the so-called Dahlquist criterion [7] at the application temperature.
Once the adhesive sticks, the cohesive strength of the material determines the mechanical properties of the bond. Conventional adhesives are functional to the point of bond failure. For optically clear adhesives, they are functional to the point of cavitation that can occur at a significantly lower strength than bond failure [8]. The cohesive strength of an OCA can be designed to resist cavitation and bubble formation when it is warranted.
OCAs are often tested for reliability and durability at elevated temperatures and humidity (e.g. 65°C/90% RH). It is important to have sufficient adhesive strength to maintain performance through these conditions. Potential failure modes include moisture ingress at the interface and bulk plasticization of the adhesive. The adhesive should be selected to have sufficient strength based on the design of the module/device and the necessary durability for the adhesive.
Optically clear adhesives are typically based on acrylate chemistry, having a refractive index of 1.47–1.48 that is comparable to glass and other important materials (e.g. PET, polarizer, etc.) in a display device. By matching the index and using an adhesive to replace an air gap, this significantly reduces the amount of light reflected at an interface (∼4% [9]). By using an OCA, both contrast and brightness can be improved in a device.
Reliability and durability of OCAs in elevated temperatures and humidity can have an impact on optical properties. The adhesive can absorb moisture under these conditions, becoming supersaturated at elevated temperatures. When the adhesive returns to ambient conditions, the excess moisture phase separates in the material becoming apparent as haze in the bulk of the material. This can be avoided by designing the adhesive to be anti-whitening [10]. Durability under UV exposure is a requirement in automotive and high performing consumer electronics applications. A common failure mode under these conditions is yellowing. Careful materials selection and formulation by the materials supplier can prevent yellowing by UV. Circular polarizers in OLED devices can reduce UV transmission to the OLED panel [11]. As POL-less devices [12] become a reality, the OCA will need to take on UV blocking functionality to protect the OLED device.
The electrical functionality of OCAs includes protecting sensitive touch sensors as well as enabling superior touch functionality. Industrial pressure sensitive adhesives often contain acrylic acid [13] to achieve good adhesion. Acidic species corrode touch sensors, such as ITO. Therefore, adhesives selected for bonding in optical applications must be acid-free. The potential module stack configurations for touch will be described in the next section. OCAs can be designed with an optimal dielectric constant at the touch sensing frequency (100 kHz) [14] from low (Dk < 3) to high (Dk > 9) to maximize the signal-to-noise ratio and minimize current and power to drive the touch circuit.
The first OLED displays bonded in consumer electronics were rigid (Figure 1a) and sealed in glass barriers. While they cannot provide the promise of flexible form factors, the OLED patterning process can still make non-rectangular form factors such as rounded corners or notches, although LCDs can now also create these shapes of viewing areas. Rigid OLEDs also can provide higher contrast and wider color gamut compared to liquid crystal displays (LCDs), but the requirements for the adhesive are not dissimilar to those for rigid LCD optical bonding.
OLED displays may be categorized according to the type of encapsulation and touch sensor used. (TFT = thin film transistor) (a) Rigid OLED, so named because the OLED is protected by an inflexible glass barrier with frits sealing the edges. Such designs may use a transparent conductor deposited on the glass as a touch sensor or use a separate film layer, as in (b) and (d). Architectures b-d use thin, flexible encapsulation (TFE), enabling these OLED to flex and bend. (b) GF1 means one glass cover and one film touch sensor layer. (c) On-cell touch, also called touch on encapsulation (TOE), is similar to (a) but with the sensor deposited on the flexible encapsulation layer. Therefore, the sensor substrate can be thinner than in GF1. (d) Another popular design emphasizing touch performance is GF2, which uses a single film layer with touch sensing layers patterned on both sides. (Graphic by Erik Iverson, 3M Display Materials & Systems Division).
When OLEDs are manufactured on thin, plastic substrates like polyimide, they can enable new form factors that are bent or formed into curved shapes (Figure 1b–d). Now many different manufacturers are introducing dynamically flexible devices that can fold repeatedly, such as the Royole FlexPai [15], Samsung Galaxy Fold [16], and Huawei Mate X [17]. Besides these single-axis folding devices, the LG Signature OLED TV R9, announced in 2019 [18], demonstrates that even very large OLED modules can be constructed to roll open and closed from a cylindrical shape less than 30 cm in diameter. Although TVs are not often touch-enabled, this type of flexible device should still use optical bonding to add protective layers to the OLED.
Whatever the form factor, OLED display modules all require additional layers for durability, user interface, and optical functionality. At least one layer each of cover window (CW), touch sensor (TS), and circular polarizer (CP) is generally included, and these must be laminated together with OCA or LOCA for best contrast, brightness, and mechanical durability. The cover window is generally made of glass, although in a few cases manufacturers have used plastics like polycarbonate (PC), polyethylene terephthalate (PET), or clear polyimide (CPI). Plastic cover windows will not shatter and can more easily flex to meet the needs of dynamically foldable or flexible displays. Commonly an ink border or bezel, 10–60 μm thick, is printed around the perimeter of the CW to hide non-transparent supply circuitry in the TS and display layers.
The touch sensor itself may include a thin passivation layer over the functional layer (usually made of ITO, but sometimes metal mesh or silver nanowires) to protect the sensor from environmental aggressors. The CP may be positioned above the touch sensor (Figure 1b) to decrease the visibility of circuit patterns in the touch sensor. While Figure 1 shows at most one separate TS layer, closely related to GF2 (Figure 1d) is GFF (not pictured), in which two films comprise the touch sensor, each with one sensing layer, adhered with a thin OCA between them. Without separate sensor layers to resolve horizontal and vertical position, the touch sensitivity and precision of a GF1 design may be less than a GF2 design.
As of 2018, OLEDs were used almost exclusively in smartphones and smartwatches, so special requirements for bonding larger displays (e.g., notebooks, monitors) are less defined at present. The requirements and benefits of optical adhesives are most defined for the Cover Window OCA (often called OCA1) and Touch Panel OCA (OCA2 or OCA3, depending on the position of the polarizer). Either of these adhesives may also be a liquid resin (OCR).
Besides the general requirements for optical adhesives described in Section 1, OCA1 requires a balance between adhesive strength and capability to cover the step height of the ink bezel. Certainly strength, usually in terms of a high shear modulus, is critical to help the whole display resist impacts, a major source of user frustration every day when screens break. OCA1 is closest to an impact event on the cover window surface, but all adhesives bonded together in the display system will contribute to its resilience to impacts when the device is dropped.
On the other hand, the OCA must move sufficiently under the shear forces of lamination but then hold its position and shape afterwards, even through temperature cycles of regular use. As bezels are often now less than 1 mm wide, the OCA must bond over an ink step that may be less than 10 times longer than it is high – a challenging aspect ratio to cover without trapping an air bubble at the base of the ink step. Furthermore, the OCA must be strong enough to resist temperature cycling and moisture exposure that could pull it away from the ink step, creating edge bubbles. Bending the display around a curved edge only increases the stress on the adhesive and magnifies the challenges.
The inherent viscoelasticity of OCAs as pressure-sensitive adhesives enables good step coverage of ink or flexible printed circuit (FPC) bond lines. However, as design trends push displays to be thinner and thinner, the solution for great step coverage often comes with UV post-curable OCAs, when narrow bezels make LOCA impractical. Such OCAs are applied in a more viscous, yet still solid, film form with some initial tack. They can flow with the pressure of lamination to cover steps ink steps that are 30–50% the thickness of the OCA. A heated autoclave process step may further improve step coverage capability. Then the laminate is irradiated with light, generally in the UVA spectrum, to increase the bonding within the adhesive, effectively “locking” it in place to improve its durability to the level of a high-modulus adhesive.
In most designs, especially those with the touch sensor on the encapsulation (Figure 1a,c), OCA1 benefits from a higher Dk, as much as 9, to increase capacitive coupling between the finger and the sensor. However, designs with a separate touch sensor (Figure 1b,d) often require a lower Dk, < 3, for the touch panel OCA to decrease coupling of electromagnetic interference (EMI) noise from the display. In either case, however, stability of Dk is important, over operating temperatures and humidity (moisture absorption generally increases Dk) and through the life of the device, as an accelerated aging test would simulate. ΔDk < 0.3 is a good guideline, and higher performance applications may require a narrower range.
These properties benefit reliability, durability, and esthetics – all values to the end user of the device. On the other hand, manufacturers and the display supply chain have other requirements. To improve overall process yield and efficiency, these players desire re-workability: targeted or triggered failure of the adhesive cleanly and without residue from one interface. Then components may be separated; expensive parts, especially the OLED and the cover glass, may be recovered. The challenge is that the re-work condition – be it heat, cold, light exposure, or some other factor – must be outside the realm of normal operating conditions so that the display does not de-bond prematurely after it leaves the factory line.
Dimensional stability is another property more visible to the manufacturers than to the end user. OCAs may be delivered as master rolls, and LOCAs will be dispensed or printed as a liquid, but for aggressive tolerances and more complex shapes like rounded corners, manufacturers often opt for individual pre-cut adhesive parts. In that case, the cut OCA must maintain its shape and dimension through environmental conditions of shipping and duration of expected shelf life. The flow, creep, or oozing of the adhesive at elevated temperatures must be limited; consider that the inside of an uncontrolled shipping container can easily exceed 50°C. Similarly, the shipment and packaging format interplays with the formulation; the sustained pressure of a stack of cut parts should also cause only minimal oozing. These properties for cut-part stability are often at odds to the viscosity needed for an uncured PSA to cover steps, as described earlier.
Most OCAs for display bonding are designed to resist whitening, as described in the previous section. Some degree of water resistance has been valuable in OCAs, but the next frontier may be resistance to a broader range of chemical ingress, especially for designs in which the bezels are very narrow or non-existent. Wearable displays also encounter more splashes compared to phones, which may often be partly protected inside a pocket or bag. Normally, a rim tape or lens bonding adhesive may adhere the cover window to the device housing underneath the bezel, and materials chemists may use a wider range of polymers to block chemical ingress, since the material does not need to be optically transparent. The challenge is heightened since everyday chemicals that might contact screens include oils/fats (cooking oil, sweat), alcohols, acids (soda, vinegar), and bases (ammonia, cleaning products) – both hydrophobic and hydrophilic substances.
While manufacturers generally select OCAs for OLED separately from the layers they bond, the CP OCA is widely sold with the CP itself, a different supply chain. Thus, low cost for the integrated product is key, in addition to technical requirements of good adhesion to the CP at a thickness of ≤25 μm. Since the polarizer absorbs a large fraction of UV light, this OCA cannot practically be UV post-curable. As future CPs continue to decrease in thickness [19, 20, 21], with thinner protective layers around the optically active layers, the CP OCA may need to serve a greater role in protecting the polarizer from harmful environmental factors.
The performance requirements of an OCA to bond layers in a flexible OLED display are quite different from a rigid, flat device. The neutral plane must be balanced to minimize strain in critical layers of the device. Thin film transistors (TFTs), thin flexible encapsulation (TFE), and touch sensors are predicted to be most vulnerable, although newer silver nanowire and metal mesh sensors are more flexible than ITO [22, 23]. Although manufacturers continue to improve the durability of OLED displays, publicly available literature indicates that critical components are still quite sensitive to strain. The SiO2 layer of the TFT on polyimide may break at 0.2% tensile strain [24] and the TFE at around 0.3% in bending [25].
When the form of the device requires the OLED to bend only once (during manufacturing), the cover window can be made of glass, which offers the best resistance to scratches and protects the display from impacts to the screen. However, the modulus (i.e., stiffness) of the glass is much higher than the other plastic films of the display (polarizer, touch sensor, OLED), whereas the plastic films feel a “spring-back” force due to their tendency to relax back to their original flat form. Since the glass will not move or deform, the OCAs in the curved display module must have very high adhesion to hold the plastic films in their curved state; otherwise they will pull away from the glass at the bend and leave bubbles.
Examples of OCAs that have the strength needed for durable curved bonding are 3M™ Contrast Enhancement Films (CEF) 30xx and 31xx, where xx denotes the thickness in mils. Table 1 describes one important property, peel adhesion, for these adhesives. Their primary difference is that CEF30xx is UV post-curable for step coverage, as described above, and its samples in the table were cured with 1 J/cm2 UVA prior to peel testing.
180° Peel adhesion (N/cm) from float glass for curved OLED display OCAs after varying dwell times.
ASTM D3330 modified test method, 1-cm-wide strips, 305 mm/min peel rate, 2.0 mil polyester backing. All dwells at 23°C/50% relative humidity.
To minimize strain on a flexible OLED display, an adhesive should either perfectly mechanically decouple the layers from each other in bending (i.e., with very low modulus) or adjust the position(s) of the neutral plane(s) during the bend. Plastic OLED displays have some inherent flexibility and have been demonstrated to fold thousands of times to a radius of 4 mm or less [26, 27], but the right adhesives are required to integrate the display layer into a durable, functional device while maintaining that flexibility. Besides balancing the neutral plane(s) to minimize strain on the OLED, when the device is folded closed, the adhesive should have minimal creep to avoid flowing and changing in thickness in response to stress. Upon unfolding the device, no buckles or wrinkles should be visible, and the adhesive should assist it in recovering quickly to a flat, smooth profile. Finally, all these adhesive properties should vary as little as possible over the operating temperatures and conditions of the device. These requirements point to a soft, elastic material with a low glass transition temperature (Tg), below the minimum operating temperature. If operating temperatures often extend down to −20°C, Tg < −30°C would be a minimal requirement.
The elasticity requirement contrasts with the common viscoelasticity of OCAs in static applications, and a soft (low modulus) adhesive would typically also sacrifice adhesion. Practically speaking, the foldable OCA should still maintain peel adhesion of 1 N/cm at a minimum. The surface energy and cleanliness of the interfaces with the adhesive also affect adhesion, however, so this property may be improved with plasma treatment or primer layers to increase surface energy.
When a flexible display is expected to bend thousands of times, a foldable OCA should retain these mechanical properties with minimal shift or hysteresis through repeated stress/strain cycling. Besides testing in application, the adhesive properties may be characterized through tensile, compressive, and shear loading, for example, using mechanical load frames, rheometers, or texture analyzers [28]. Some mechanical testing to support the simulation of flexible adhesives is described later in Section 4.
Even a folding radius of 5 mm can require shear strain of >300% in the adhesives during folding (depending on the thickness of the various display layers). Foldable adhesives must certainly shear to this extent without breaking or permanently deforming but are also expected to release strain quickly when stress is removed upon unfolding. However, recovery time of the flexible display also greatly depends on the properties of the other film layers, which have much higher moduli, so it is difficult to distill the recovery requirement for the system into a generic recommendation for the adhesives.
Many trends in OLED design focus on enabling greater flexibility, and new adhesives will be needed to support this as well. Through the next decade, manufacturers will push for narrower folding/rolling radii, multiple folding axes in displays, and longer device lifetimes, especially in terms of cycles of flexing. As folding radius decreases below 3 mm, the required shear strain will likely increase from 300% to roughly 500 to 700% or more. Additional folding axes will also increase the total magnitude of shear displacement, as each axis adds its own displacement to the system. A rollable display can be considered as the limit of many axes of folding across the length of the device. Rolling devices will initially launch with radii of several centimeters, which is larger than today’s one-axis folding displays, but the shear will add with each bend such that the “creep” with applied stress will be a more critical property. With larger creep, even a flexible adhesive could shear out several mm at the edge when the display is rolled, resulting in unsightly uneven edges or, worse, display layers pressing into the bezel/frame bonding and generating further stress.
Thinner display modules will assist flexibility, so trends in integrating functional components are likely to continue. These may include coated circular polarizers [19, 20, 21] or color filters integrated with the OLED encapsulation [12]. With thin flexible cover windows, expect adhesives on either side of the OLED display to play a greater role in protecting the module from impact damage. This will be especially true for plastic CWs compared to glass, since they have lower elastic moduli.
Plastic cover windows may see further growth in automotive displays, but for different reasons. Some manufacturers and safety authorities have been concerned about the possibility of display cover glass shattering in an impact or crash and thus have preferred plastic CW for safety reasons. High-performance plastic CWs are often made of PC or PMMA (poly[methylmethacrylate]), so durable bonding to these low surface energy plastics, with their tendency to release gases under heating, will be important to future automotive OCAs. The reliability and accelerated aging tests for transportation applications are generally more severe than those for consumer electronics. The displays must withstand extremes of heat (often −40 to +110°C), humidity, and light (especially UV) irradiation, but also conditions like sand for desert environments and salt spray on the coasts. Finally, the interiors of many concept cars already feature large displays on the complex curves that designers favor for esthetics and ergonomics. Expect curved displays to grow in size and in popularity in production models in the coming years.
Although it takes time to decrease costs and prove reliability, gradually OLEDs will expand into outdoor applications as well, as consumers begin to expect a certain level of display quality from their everyday interactions with personal and mobile devices. These outdoor bonding applications will demand reliability from the OCA, like the automotive market. Transparent OLED displays are still in their infancy and will likely require lower levels of optical absorptivity, haze, reflectivity, and color for all layers, including optical adhesives.
A different design trend in OLED displays that has already begun in today’s devices is the integration or hiding of the many cameras and sensors that now support the devices’ interactions with their users and environments. The goal is always to expand the active area to occupy an ever-greater fraction of the viewable front of the device. Additionally, a camera behind the display provides a more natural interaction in video calling; the camera may track a user’s gaze at the same location where the user views the other person’s face, giving the impression of eye contact. The implication for bonding with OCAs is stricter dimensional control and tolerance requirements, extending to non-rectangular shapes. Already many sensors and cameras can fit in a droplet or notch shape cut of out of the display and adhesives at one edge of the screen. When the camera(s) are behind the display, some adhesive layers must precisely maintain a small hole in the middle of the part, as an aperture for the camera.
3M has been investigating fatigue and shear performance of polymer film substrates and multi-layer stacks consisting of OCAs (Optically Clear Adhesives) and polymer films in response to dynamic bending. This work was prompted, in-part, to support materials and systems development in the realm of foldable OLED (Organic Light Emitting Diode) market technologies and applications. One device that is used to study the dynamic bending performance of these films and film stacks is an internally-designed and built bend tester. Samples can be mounted to the bend tester and folded to a specific bend radius and number of bend cycles at a defined cycle rate (bend cycles per minute). From a materials perspective, failure in the form or yielding, breakage and buckling can occur during testing. In actual flexible device constructions, the light emitting and barrier layers can be compromised over certain stress and strain thresholds. These failures are influenced largely by the stress or strain amplitude as the samples are placed in the folded conformation of interest. In this section, we will discuss the methodology behind development of a controlled and repeatable folding test that minimizes bending stress on foldable test specimens, types of defects observed in single and multi-layer polymeric stacks consisting of OCA, and additional methods of concept differentiation by incorporating ITO (Indium Tin Oxide) coated PET (polyethylene terephthalate) into the multi-layer test specimens.
One of the first design parameters considered during initial folding test method development is the hinge design (or pivot locations) of the test apparatus. It is important to have at least some understanding of the impact of hinge design selection. Some types of hinge design can impart added strain (or stretching) on samples during the process of folding. With single hinge folding design, or folding with only one pivot point, there will be one or more critical angles in which the test specimen is stretched beyond its original length. This type of tester design is undesirable because the design of the tester can damage the samples, and will introduce added variables, such as test specimen attachment location and attachment adhesive properties, that will dictate how much overall strain is imparted to the sample during the action of folding and unfolding. Slight changes in attachment location and attachment adhesive properties will have an impact on variability and reproducibility of the test results. Note, this logic can be applied to certain mandrel bend folding designs as well, if the strain on test specimens is not actuated to prevent sample lengthening or stretching during folding. For this reason, we have defined a dual pivot testing apparatus (Figure 2), which can prevent added strain or stretching of the samples during folding.
(a, b) Specimen geometry during folding for a single vs. dual pivot test apparatus. Tester mounting plates are depicted in blue, attachment adhesive is depicted in yellow, test specimen is depicted in orange, pivot locations are depicted by ‘+’ signs. (a) shows a single pivot hinge design, in which samples can be stretched at a critical closing angle during testing. (b) shows a dual pivot hinge design, which can eliminate added stretching of the test specimen during folding. (Figures by Tom Corrigan, Ph.D. 3M Corporate Research Systems Laboratory).
In many cases, test specimens will consist of alternating layers of polymer film and adhesive. The primary roles of the adhesive in such constructions will be to adhere the layers together and to prevent added strain on sensitive layers, such as the display or fragile coatings. The mechanical benefit of the adhesive is maximized when specimen layers can freely move and shear across one another during folding and unfolding, thus minimizing stress on fragile layers. For this reason, attaching specimens to the test apparatus using adhesive (instead of clamping) is recommended, especially if it is representative of actual folding device construction. If specimens are attached to the folding test apparatus with clamps, there will be new test variables to consider, such as clamping pressure and location.
When attaching specimens to the folding apparatus using adhesive or tape, the next decision becomes where to attach the test specimen. Samples attached too close to the apex of the fold can add strain on the samples, due to lateral pulling of the samples to the mounting plates during folding. This can also add undesired variability to the test response, in addition to added strain on test specimens. Test specimen shape in the folded configuration can be measured or modeled. For our folding test method, we have defined an attachment location (denoted as Lfree in Figure 3b, below) not closer than 3*g/2, where g is the distance between confining test plates and attachment adhesive.
(a, b) Specimen geometry denoting location of attachment location with bond all the way to edge of substrate backing in (a), while (b) depicts a region without adhesive contact near the fold region.
Misalignment of the test specimen can be caused by off-centered attachment of the test specimen, misalignment of the pivot points (non-parallel or collinear; Figure 4), or curved/warped mounting plates. Such forms of misalignment can result in different patterns and variability in the test response (from left to right sides of the test apparatus, for example; Figure 5).
Shown above are modeling results, which depict changes in strain on test specimens depending on their alignment on the test apparatus. (Courtesy of Samad Javid, 3M Corporate Research Process Lab).
(a, b) Results from testing of 4mil low melt PEN (polyethylene naphthalate) at a nominal gap size of 4 mm. Sample position is measured in inches from left to right side of test apparatus. Samples were checked every 10,000 fold cycles. (a) shows the difference in test response observed when test plates are very flat (2 test cycle replicates are depicted on this plot by red and blue), vs. curved with variation of folding gap by only 0.05 mm as measured with a feeler gauge (data depicted as a general smile pattern in green). (b) shows a sinusoidal test response (plotted in red and green) as a result of loose bearings design, which control the motion profile of the test plates. Tighter bearings design, in this case, yield a flatter more controlled test response profile (plotted in blue).
Both temperature and humidity can affect the test response, particularly for multi-layer test specimens that include adhesive in some layers, since some adhesives may be quite sensitive to moisture uptake. Dependent on the substrates used, this water uptake could apply to films, as well. Specimens should be conditioned at well-defined environmental parameters prior to testing. Testing should also take place in a controlled temperature and humidity environment. Doing so can help improve the repeatability and reliability of the test.
Lamination conditions, sample edge quality and surface treatments that impact adhesion can also influence the test response. Differing amounts of stored stress introduced during manufacturing, and tension applied during the lamination and sample preparation process can change the starting stress states of a test specimen, which can then influence the stress profiles during folding and unfolding.
Depicted below are several types of failure modes observed during bend testing of single and multi-layer test specimens. Crazing (Figure 6a) is caused by slippage of crystal structures and void formations in polymeric films. Local buckling (Figure 6c) is caused by adhesion failure between layers. Global buckling (Figure 6d) is caused by severe instability, which can result in inverted folding of the test specimen.
Depiction of typical failure modes in foldable testing, including substrate crazing (whitening) (a), breakage (b), local buckling (c) and global buckling (d).
There is widely available literature to explain the effects of decoupling and isolating multiple neutral planes in a multi-layer construction [14, 29]. In the ideal case, the neutral planes of each layer in the composite construction are preserved by frictionless slip (or perfect decoupling of each layer). In reality, the lay-up construction (modulus and thickness of each layer), in addition to assembly (such as tension during the lamination process) of the test specimen or display stack will influence stress profiles. 3M Foldable OCA has a lower modulus over a wide range of operating temperatures, as compared to standard commercial OCAs. This offers greater ability to decouple the stiff layers in a flexible display module and reduce the overall bending strain [29, 30].
A simple experiment was performed to assert the performance of 3M™ OCA CEF35, a 3M Foldable OCA. A thin layer of ITO was coated onto 2mil PET. The ITO coated PET was used to create 3-layer test specimens, comprising either a standard OCA 8146–2 or CEF35 at the same thickness of 2 mils (Figure 7a). The test specimens were folded, with ITO on the out-folded/tension side, using a dual pivot bend tester. The folding rate for this test was 30 cycles per minute, with nominal folded gap size of 4 mm. Samples were conditioned for 24 h and tested at 23C, 50%RH. Electrical resistance of the ITO coating was measured at the end locations of each test specimen (using an Ohm meter) after 0, 1, 10, 100, 1000 and 10,000 fold cycles. Results (Figure 7b) showed significantly less resistance increase for stacks constructed with CEF35 than for those containing OCA 8146–2, proving experimentally that CEF35 more effectively decouples the polymer film layers, due to a lower shear modulus (G’) and higher yield under minimal load, thus, causing less damage to the conductive layer.
(a) shows descriptions of test specimens comprising a single layer of 2mil PET, and 3-layer samples comprising of 2mil 3MÔ OCA 8146–2 (a standard 3M OCA) and 2mil 3MÔ CEF35 (a 3M foldable OCA). (b) Results show that less resistance increase is observed for the test specimens comprising of 3MÔ foldable OCA, CEF35, than for specimens containing standard 3MÔ OCA 8146-2. These results suggest that the strain amplitude on the tensioned ITO coated side of the test specimen is reduced when using 3MÔ foldable OCA, thus reducing damage to the fragile coating.
In conclusion, there are several factors to consider when designing a reliable and repeatable folding test method. Factors such as hinge or pivot design, attachment location, sample and fold axis alignment, as well as sample preparation and conditioning, and surface treatments can all have an impact on the reliability and repeatability of the test. Once these factors are controlled, the folding test can be an effective tool for use in differentiating multi-layered constructions representative of foldable displays. IEC standard 62715-6-1 [31] can be referenced and calls out several different methods of bending deformation that can be used to evaluate Flexible Display Devices. Common failure modes include crazing, breakage, local and global buckling. Most, if not all, of these failure modes can be influenced by the properties of the adhesive used to construct the test specimen. 3M Foldable OCA can help to decouple the polymeric film layers of a multi-layer test specimen, and therefor reduce strain on fragile coatings and components, due to its low modulus as compared to standard OCAs, such as 3M OCA 8146.
For foldable AMOLED (OLED) display panels, the repeated folding and unfolding create new mechanical requirements and challenges beyond those of fixed displays. In most applications, the multiple functional layers of a foldable display are bonded by optically clear adhesives (OCA) to form a multilayered thin panel or film stack that is flexible to allow folding of the panel.
The folding of a multilayered panel will introduce bending stress and shear stress not only within the individual layers but also between the bonded layers. Depending on the panel layup design, these bending stresses can reach very high levels causing various failures including fracture of individual layers or sensitive components within a layer, delamination, and buckling. Understanding the nature of these stresses will help in producing robust designs that ensure reliable folding performance.
Because the folding of a display by nature is a problem of large deflection of a multilayer film stack, the classical beam bending theory such as the Euler–Bernoulli approach will be limited in its ability to describe accurately the bending stress and interlaminar stress. The thin nature of the OLED display also makes it difficult to experimentally measure the stresses or visualize the deformation of the layers within the panel. Modeling then becomes an effective tool to provide insights into the mechanical folding behavior. Numerical analysis methods, such as finite element analysis (FEA), offer detailed information of stress and related deformation in each layer of the film stack, and allow virtual testing to evaluate different design scenarios [14, 32, 33, 34, 35].
In this chapter, we will provide an introduction of the folding simulation of OLED display panels. The aim is to demonstrate the basic process of modeling the folding and the potential failure modes of foldable displays to help design engineers to become familiar with:
The interactions between layers of the display film stack with its bonding layers, the OCA layer, and the role of OCA on the folding performance of the film stack.
Some basic modeling methods to simulate the folding of the film stack and the OCA.
As general guidance, we will use modeling examples of a simplified but representative display film stack to describe and discuss the models and the results.
We will also focus on the roles of the soft bonding layer, the OCAs, in the discussions of the modeling results. We will examine the overall performance of the film stack to provide basic understanding of the effectiveness of a soft bonding layer in reducing bending stress and mitigating related potential failure modes. This understanding can be valuable because the material properties and thickness of the functional layers in a display, such as the OLED, circular polarizer film, and the touch sensor film are designed to achieve their specific optical or electronic functions, and the options to vary the thickness and material properties of these functional layers may be limited. Managing a film stack’s neutral plane by employing thicker or stiffer supplementary layers may be undesirable if the display panel is to be flexible. On the other hand, when the display panels become thinner, this imposes its own set of challenges in durability and usability. Optimization of the display film stack through the design of the bonding layer becomes an attractive and often a necessary option.
The typical functional layers of an OLED film stack may include: cover film, the touch sensor layer, circular polarizer, thin film encapsulation (TFE) layer, the AMOLED (OLED) display unit, the back sheet, substrate, and others. The OLED display unit itself also consists of multiple components including a flexible substrate, encapsulation/barrier, thin film transducer (TFT), and transparent electrode. In more recent developments, display manufacturers are also pursuing integration of some of these components for thin form factors with fewer layers. The OCAs are placed between layers to bond them into an integrated display film stack that is flexible to allow folding as shown in Figure 1. The common industry practice for specifying the extent of the folding is by the radius of curvature of the folded region.
The folding of a multilayered panel will introduce bending stresses, both in-plane tensile or compressive stresses and shear stresses between the layers. While each individual layer is flexible to withstand being folded into a small radius of curvature, the bonded multilayer panel will exhibit a much higher stiffness due to the larger thickness of the whole panel, and potentially generate very high bending stresses. The high bending stresses may cause failure in various forms. Of the various components and layers in an OLED display panel, the permeation barrier layer, the indium tin oxide (ITO) layer, and the oxide dielectric layers of thin film transistors (TFT) are sensitive to tensile stress and strain, and they can fracture at a relatively low tensile strain [24, 36].
While there are many other design requirements for a display unit, in terms of folding mechanical performance, flexibility, integrity, and durability without damage are required, and fracture, delamination, or buckling under repeated bending must be prevented.
Other design requirements, including impact resistance to drop impact of display device or ball/foreign object impact, and scratch resistance are also critical for foldable displays. They are interrelated with the foldability performance, and often have competing design requirements. A more systematic and holistic design approach is necessary to incorporate all the aspects of design to achieve balanced optimal performance with some trade-offs, if necessary, among the various competing design requirements. Various modeling work has been performed in these areas at 3M, however, this belongs to a more expansive scope beyond that of the current chapter. For a more focused discussion, this modeling section will be limited to the topic of integrity for foldability.
In the following sections, the general practice of finite element analysis for simulating the folding of a film stack will be discussed first, followed by a modeling example to illustrate the potential failure modes of the film stack that need to be addressed in the design of foldable displays and the effects of OCA in mitigating these failure modes.
The thin film nature of the film stack makes it suitable for using a 2D model to represent the stack without losing much fidelity, especially when edge effects are not significant. To model the interactions among the different functional layers, each layer should be modeled as an individual part of the film stack. In particular, this simulates the deformation behavior that is critical in understanding the effects of OCA on the folding performance of film stack. The finite element mesh size should be sufficiently fine to resolve the stress gradient of the critical layers both in their thickness direction and in the in-plane direction, especially in the bend region where stresses vary through the thickness direction.
The bonding of the OCA to film can be simulated by various interaction definitions such as nodal constraint or node coupling of the mesh of the OCA layer to the mesh of the substrate film layer. This approach will typically not allow the simulation of the separation or debonding of the OCA from the substrates, however, it can offer most of the needed information to evaluate the bond performance without the added complexity of simulating the debonding process. To simulate the debonding process, cohesive elements may be used to represent the OCA bond. If cohesive elements are used, care should be taken to incorporate the cohesive law that describes the debonding force-displacement of the OCA bond attached to the specific films of the actual application because the bond strength depends on the specific substrate films. Also, separate cohesive laws for tension (normal to bond interface) and shear should be used to accurately represent the OCA bond behavior which will require calibrations of the cohesive laws from test data such as those from butt joint or T-joint tests and lap shear tests. In general, the correct application of cohesive elements or cohesive contact for OCAs is more involved. Proper training on the technique will help to avoid misrepresentation of OCA bonds. It is recommended that users consult with 3M technical support for test methods or test data related to bond strength simulation.
Being a type of pressure sensitive adhesive, OCA needs to be soft enough to flow under application of pressure to wet the substrate in close proximity. This intimate contact between OCA and the substrate allows molecular interactions such as van der Waals forces to form the basis of the adhesion that underwrites the overall bond strength. This flow-like behavior of OCA can be described by a combination of nonlinear elastic and viscoelastic/viscoplastic material models.
For OCA’s viscoelastic behavior, its relaxation function can be defined in terms of a series of exponentials known as the Prony series. For the nonlinear elastic or hyperelastic constitutive models, the models such as the polynomial hyperelastic models are most commonly used. They include the neo-Hookean model, Mooney-Rivlin model, and Yeoh model. All are effective in describing OCAs’ ability to be stretched to very large strain. Other forms of hyperelastic models including Arruda-Boyce and Ogden models may also be used. The commercial finite element analysis packages, such as ABAQUS, ANSYS, and COMSOL offer the finite strain computational methods and material model libraries that allow advanced simulation of OCAs. Users can apply the material model calibration tools provided by the finite element analysis software packages to evaluate the material parameters for these constitutive models from OCA material characterization test data. It is also recommended that they contact 3M technical support for information on OCA material data for their specific applications.
Several material characterization tests are needed to generate data for the calibration of the constitutive models mentioned above. For calibrating the elastic or hyperelastic material models, one or more of the tests listed below needs to be performed on the OCA:
Uniaxial tensile
Simple shear
Biaxial tensile
Compression and/or bulk compression
For viscoelastic model calibration, the dynamic mechanical analysis (DMA) test can be performed to produce master curves of the storage modulus and loss modulus of OCA to calibrate the Prony series. Otherwise, relaxation or creep test data at various strain rates and temperatures of interest may be used for the Prony series calibration.
For calibration of OCA bond strength models, such as the cohesive zone model, the proper measurements of the bond strength using T-joint specimens and lap shear specimens should be emphasized. These tests should be performed on the actual substrate materials of the film stack, especially if the potential failure mode may be adhesion failure. 3M Technical Support can be a source for information related to the test methods for adhesive characterization.
The following is an example of finite element analysis of dynamic folding simulation of a display film stack, followed by discussions of the analysis results to assess the folding performance.
In the finite element analysis (FEA) presented here, a simplified 7-layer film stack was used to represent a foldable OLED display (Table 2). The film stack was assumed to be attached to two rigid back plates joined by hinges. The center portion of the film stack was not attached to the rigid back plate to allow for folding of the stack. The folding action simulated here is the so-called ‘out-folding’ such that the film stack is folded towards its back layer. In the fully folded configuration, the space between the straight sections of the outer layer is 10 mm resulting in the bend section of the film stack forming an approximate semi-circle of radius 5 mm as shown in Figure 8. In the simulation, the film stack was folded in 3 s, then held in the folded configuration for 24 h before it was unfolded in 3 s. The material properties and the thickness of each layer used in this work are listed in Table 2. The total thickness of the film stack simulated here was 0.475 mm (layup 1) and 0.275 mm (layup 2). The simulation was repeated for the two film stack layups bonded by 3M™ Foldable OCA CEF35 and 3M™ OCA 8211. 3M™ CEF35 has a lower storage modulus than that of 3M™ OCA 8211, and exhibits a more elastic behavior as indicated by its lower Tan delta value (Table 2) than that of 3M™ OCA 8211.
Layers | Thickness (μm) | Material | Modulus of elasticity, E, (GPa) | Storage Modulus, G\', (GPa) at frequency of 1 rad/s | Tan Delta |
---|---|---|---|---|---|
Cover film | 150 (50) | PET | 3.5 | NA* | NA |
OCA | 25 | 3MTM CEF35 (OCA 1) 3MTM OCA 8211 (OCA 2) | / | 0.03E-3 0.07E-3 | 0.33 0.70 |
Circular polarizer | 75 (125) | Triacetate | 3.2 | NA | NA |
OCA | 25 | 3MTM CEF35 (OCA 1) 3M OCA 8211 (OCA 2) | / | 0.03E-3 0.07E-3 | 0.33 0.70 |
AMOLED | 75 | Polyimide substrate | 3.5 | NA | NA |
OCA | 25 | 3MTM CEF35 (OCA 1) 3M OCA 8211 (OCA 2) | / | 0.03E-3 0.07E-3 | 0.33 0.70 |
Back plate | 100 (150) | PET | 2.7 | NA | NA |
The simplified 7-layer display film stack layup and the properties used in the simulation.
*NA = Not Applicable
The thickness shown in brackets in the table are the values used for stack layup 2.
Simulation results showing the 4 stages of folding. The film stack is folded towards its back layer in the form of the so-called “out-folding”.
The simulation was performed using the ABAQUS finite element analysis package. Due to the large ratio of film stack panel width to thickness, a 2-dimentional plane strain model meshed with the plane strain solid element, CPE4, was used. Six elements were used through the thickness for the OCA layer, and four elements through the thickness for each of the other functional layers.
The following potential failure modes typical for foldable displays were predicted for various film stack layups by the simulation and are also observed in experiments:
Failure due to tensile strain from bending exceeding the critical values for specific components/layers in the display film stack
Buckling
Debonding between layers of the film stack
Figure 9 shows the finite element analysis results of these failure modes. In the following sections, each will be discussed with emphasis on the effects of OCA’s soft properties on the bending performance.
The predicted potential failure modes of foldable display film stack.
For film stacks bonded by 3M™ CEF35 and 3M™ OCA 8211, the results show that the lower modulus of 3M™ CEF35 allows large shear slippage between layers leading to reduced bending stress in the film stack. The in-plane strain in the OLED layer is shown in Figure 10 for the two film stacks bonded by 3M™ CEF35 and 3M™ OCA8211. The maximum tensile strain occurs in the bend section at the bending symmetry plane after the film stack is completely folded. The maximum tensile strain ranged from 0.2% to 0.6% in the stacks bonded by 3M™ CEF35, and from 0.4% to 0.9% for stacks bonded by 3M™ OCA 8211. Depending on the critical strains of the OLED, ITO, or TFE, a less stiff OCA may make the difference between failure and no-failure of the display panel.
Contour plots of in-plane bending strain in the OLED layer when the film stack is fully folded for the film stacks bonded by 3M OCAs (only the OLED layer is shown in this figure).
When the OCA’s shear deformation between layers is sufficiently high to allow adjacent layers to slip over each other, each layer can bend without much constraint from the adjacent layers. This shear decoupling effect can result in much reduced bending stresses in some of the layers leading to a neutral plane in each of the layers, especially for the layers closer to the center of the film stack. In Figure 11, the bending stress (the stress in the direction parallel to the neutral plane of the film stack) of the film stack bonded by 3M™ CEF35 is shown. The plot shows the bending stress distribution at the cross-section of A-B, which is the location where the maximum bending stress will occur within the bend region of the film stack. For this 7-layer film stack of a total thickness of 0.475 mm (Table 2), the bending stress on each of the three OCA layers is negligible due to its low stiffness. The low stiffness of OCA, on the other hand, facilitates relatively high shear strain, in the range of 300–400% (Figure 12). This large shear strain between the layers allows each of the CWF, OLED, and back plate films to bend relatively independently from others resulting in a neutral plane in each of these functional layers, as indicated by the zero-bending stress location within each layer.
Bending stress distribution at the cross-section A-B which is the plane of symmetry of the folded film stack.
Contour plots of shear stress in the transition region for the film stack (layup 1) showing the large shear deformation of the OCA layers.
The ability of soft OCA to shear easily provides an effective design option to achieve multiple neutral planes in a film stack. This can be of great value since it can enable more freedom of choice regarding material properties and thicknesses of other functional layers without compromising their specific optical or electronic performance in a display.
Under bending, a thin display film stack that is partially attached to a stiffer back plate is susceptible to buckling failure that leads to optical distortion and possible debonding, either within the film stack layers or from the back plates on which the film stack is attached. Buckling of the film stack can be further categorized into global buckling and local buckling types.
Global buckling typically gives the film stack a wavy appearance. It happens during unfolding after the film stack is held in the folded configuration for a period of time. In the folded configuration, shear creep in the OCA may occur which can be observed at the end of the film stack where each layer slips over the adjacent layer (Figure 13). This creep induced shear slip cannot be immediately recovered upon unfolding. During unfolding, the top layers of the film stack shown in Figure 11 will then be under compression while the bottom layers will be in tension. Depending on the amount of the shear creep and the overall stiffness and thickness of the film stack, this may lead to instability and global buckling as shown in Figure 14. The more elastic behavior of 3M™ CEF35 limits the shear creep deformation and, in turn, leads to reduced buckling during unfolding.
Simulation results showing the shear deformation between layers (a), and the predicted maximum shear strain in OCA layer and the comparison with the bond strength of the OCA (b).
Displacement contour plots comparison of buckling of the film stack bonded by 3M™ CEF35 and 3M™ OCA 8211 immediately after unfolding showing the improved buckling resistance of 3M foldable OCA. The displacement, U2, is in the direction perpendicular to the film surface (unit: mm).
Local buckling often appears as a fine and thin wrinkle or wrinkles on the surface on the compressive side of the folded film stack [36]. It occurs during folding but may still be visible after unfolding if the buckling is allowed to set in over a period of time or if the buckling causes debonding in the region.
During folding, high compressive stress can develop in the bend region. Local buckling occurs only in the layers on or close to the surface of the film stack on the compressive side of the neutral plane. If the compressive stresses in these layers are not reduced through OCA’s shear deformation, they may cause these layers to buckle or bulge out especially if any geometric off-axis imperfection is present in these layers. As shown in Figure 15, the buckling deformation will stretch the OCA that bonds the buckled layers to the remaining un-buckled layers resulting in tensile stress in OCA in the direction perpendicular to the bonding interface. Depending on the OCA bond strength, this tensile stress can cause delamination in this region.
Predicted local buckling on a film stack bonded with an OCA with a stiffness of 10% of that of 3M™ CEF35. The inserts are the photos of a local buckling on the actual film stack.
Local buckling was not predicted in the film stacks bonded by 3M™ CEF35 or 3M™ OCA 8211 (the layup specified in Table 2). However, if the OCA modulus is reduced to 10% of that of 3M™ CEF35, the simulation predicted that local buckling could occur which is shown in Figure 15 for a particular film stack. On the other hand, reducing the thickness of OCA to increase the constraint to buckling deformation can effectively improve the local buckling resistance as shown in Figure 16. Our studies have shown that reducing OCA thickness and increasing OCA stiffness can improve film stack’s buckling resistance, while reducing OCA stiffness to facilitate shear slip is also critical in reducing the compressive stress that is the root cause of buckling. All these demonstrate that the design for buckling resistance is a balancing act and represents one of the most challenging aspects in film stack optimization. The competing requirements of stiffness to resist buckling and flexibility for folding, as well as, for minimizing the cause of buckling further highlights the importance of leveraging OCA’s broader range of properties to achieve the optimal film stack performance.
Simulation results showing the effect of OCA thickness on local buckling. The film stacks shown here were bonded with 3M OCA of different thickness. The ratios of the surface layer thickness to the underlying OCA layer thickness is 2.0 for the layup on the left, and 1.0 for the layup on the right.
Another failure mode often observed in the foldable display is delamination or debonding, which is characterized by separation of layers either near the ends of the display panel, or within the bend region.
Typically, the debonding at the end of the film stack is due to shear strain in the OCA exceeding the OCA bond shear strength, while the delamination within the bend region is the result of high interlayer tensile stresses on OCA due to local buckling as described above.
In Figure 12, the shear stress of the film stack is shown for the transition region where the bent section meets the straight section. The corresponding shear strain values are indicated on the plots. Figure 13 shows the shear stress at the end of the film stack. For both the film stacks bonded by 3M™ CEF35 and 3M™ OCA 8211, along the length of the film stack, the maximum shear strain occurs in the transition region. The higher the shear strain in the OCA, the more shear slip is allowed between layers, which reduces the bending stress in the layers. For the layers on the compressive side of the neutral plane, this means reduced compressive stress and the reduced possibility of local buckling of these layers. For the layups simulated in this work, the shear strain can be as high as 600% as shown in Figure 12. The softer 3M™ CEF35 allows not only large shear strain upon folding leading to improved local buckling resistance, it also can effectively resist debonding due to its high bond strength (Figure 13).
The simulation examples of folding OLED display film stacks discussed here demonstrate OCAs’ abilities to reduce bending stresses and to create multiple neutral planes in a film stack. The simulation examples also demonstrate three potential failure modes for film stacks under dynamic folding and unfolding.
Fracture due to high tensile bending stress
Buckling
Local buckling of a few layers in the film stack and global buckling of the panel where the entire film stack buckles and assumes a wavy form
Delamination or debonding
As shown in these simulation examples, these failures can be addressed through design and selection of appropriate OCAs. It is also evident that the folding performance of a display is a system-level response, where performance is governed by the properties of each layer in the stack layup as well as the display attachment methods and folding hinge design. The softest layers in the film stack, the OCAs, play a critical role in optimizing the film stack’s folding performance when the options to alter the mechanical properties or thickness of other functional layers to improve overall stack flexibility are restricted by their designed functionalities. Design of display film stacks that utilize OCAs’ unique characteristics can lead to increased robustness of integrated system solutions for foldable displays.
The authors declare no conflicts of interest.
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