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Burmeister, P.C. Bornman, J.E.J. Krige and S.R. Thomson",authors:[{id:"101403",title:"Dr.",name:"Sean",middleName:null,surname:"Burmeister",fullName:"Sean Burmeister",slug:"sean-burmeister"}]},{id:"35461",title:"The Influence of Colonic Irrigation on Human Intestinal Microbiota",slug:"the-influence-of-colon-irrigation-on-human-intestinal-microbiota",signatures:"Yoko Uchiyama-Tanaka",authors:[{id:"76302",title:"Dr.",name:"Yoko",middleName:null,surname:"Uchiyama-Tanaka",fullName:"Yoko Uchiyama-Tanaka",slug:"yoko-uchiyama-tanaka"}]},{id:"35462",title:"Pancreato-Biliary Cancers – Diagnosis and Management",slug:"pancreato-biliary-cancers-diagnosis-and-management",signatures:"Nam Q. 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Sánchez Muñoz-Torrero",authors:[{id:"91142",title:"Prof.",name:"Juan Francisco",middleName:null,surname:"Sánchez Muñoz-Torrero",fullName:"Juan Francisco Sánchez Muñoz-Torrero",slug:"juan-francisco-sanchez-munoz-torrero"}]},{id:"35466",title:"Selected Algorithms of Computational Intelligence in Gastric Cancer Decision Making",slug:"selected-algorithms-of-computational-intelligence-in-cancer-surgery-decision-making",signatures:"Elisabeth Rakus-Andersson",authors:[{id:"113450",title:"Dr",name:null,middleName:null,surname:"Rakus-Andersson",fullName:"Rakus-Andersson",slug:"rakus-andersson"}]}]}],publishedBooks:[{type:"book",id:"1807",title:"New Advances in the Basic and Clinical Gastroenterology",subtitle:null,isOpenForSubmission:!1,hash:"a7ec52cb83e9fc2064e573afcfc87a71",slug:"new-advances-in-the-basic-and-clinical-gastroenterology",bookSignature:"Thomas Brzozowski",coverURL:"https://cdn.intechopen.com/books/images_new/1807.jpg",editedByType:"Edited by",editors:[{id:"35854",title:"Prof.",name:"Tomasz",surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5714",title:"Esophageal Abnormalities",subtitle:null,isOpenForSubmission:!1,hash:"132a5e5097b78a76535fde4196596ac9",slug:"esophageal-abnormalities",bookSignature:"Jianyuan Chai",coverURL:"https://cdn.intechopen.com/books/images_new/5714.jpg",editedByType:"Edited by",editors:[{id:"28281",title:"Dr.",name:"Jianyuan",surname:"Chai",slug:"jianyuan-chai",fullName:"Jianyuan Chai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10326",title:"Advances in Hepatology",subtitle:null,isOpenForSubmission:!1,hash:"356bcd9352c844e5524bb8e79cf6e7fe",slug:"advances-in-hepatology",bookSignature:"Luis Rodrigo, Ian Martins, Xiaozhong Guo and Xingshun Qi",coverURL:"https://cdn.intechopen.com/books/images_new/10326.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1885",title:"Ulcerative Colitis",subtitle:"from Genetics to Complications",isOpenForSubmission:!1,hash:"66c280aa8909a30f1a3dc25e7c963a08",slug:"ulcerative-colitis-from-genetics-to-complications",bookSignature:"Mustafa M. 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Experts and major stake holders are trying to overcome it. EP not only effecting air, water, land but also plants, microbes, and humans. Atmospheric pollution (AP) is worse because it directly inhales by living organisms, particularly humans. Manmade activities increase the level of air pollution from preindustrial age [1].
Air pollutants are of many types and are classified on their suspension in the environment. Major air pollutants (AP) include suspended particulate which includes dust, fumes, mists, gases, vapors etc. The sources of these pollutants are diesel exhaust, coal fly-ash, mineral dust (asbestos, coal, cement and lime), metal dust (Cu, Fe, Pb and Zn), fumes, acid vapors (H2SO4), paints, pigments, black carbon and smoke from oil. Ozone level of various sites of Northern Hemisphere has been increased from 10 to 50 ppbv since 1860 [2]. Sulfate aerosols increase from 3 to 4 folds [3].
Pollutants which are suspended in the air are responsible for different diseases like respiratory and Cancer, corrosion of metals and damage of plant biochemistry. Most of these pollutants deposited on the surface of the plants and cause naissance and disturb sunlight interaction with chlorophyll, the scattering of light from these pollutants produce smog and many surface chemical reactions. Many air pollutants are in gaseous form, like oxides of sulfers (SO2 and SO3), carbon (CO2 and CO), and nitrogen (NO2 and NO3). Most of organic compounds are also present in the air like Hydrocarbons, Volatile organic compounds, poly aromatic hydrocarbons and different halogens and their derivatives. Chemical, Thermal and photochemical reactions of above mentioned pollutant caused secondary pollutants. A common example of thermal pollution is when the oxidation of SO2 occurs to SO3 by thermal reaction. If SO3 further catalyzed in the presence of Mn and Fe in water than it give rise to sulfuric acid mist. Nitrogen oxides and reactive hydrocarbons when react. They produced ozone, per-oxy-acetyle nitrate (PAN). Some order causing agents are also produced which are known as hydrogen sulfide, carbon disulfide and mercaptan while others are very difficult to define chemically.
Chemistry of atmosphere totally depends upon the chemistry of pollutant present. The activities such as stream of traffic, industrial emissions, cleaning and washing of roads, painting, repairing are the causes of air pollutant generation. Because of their harmful effects, the air pollutants are now major concern of human talks [4]. Noise pollution is also the part of air pollution. Increase of traffic and other anthropogenic activities the noise pollution is increasing day by day. It is also causing swear health effects in humans (high blood pressure, sleeplessness, nausea, depressions are common). The study revealed that air pollution is responsible for 430,000 premature deaths in Europe and almost 10,000 deaths due to noise pollution have been recorded. Due to these statistics air and noise pollution is listed in the top two stressors in the environmental burden disease [5].
Some important terms and their definitions related to air pollution. | ||
---|---|---|
Term | Definition | Citation |
Air pollution | Occurrence of dangerous particles and chemical species into the surrounding air beyond the permissible limit is known as air pollution e.g. PM2.5, NOX, SOX etc. | [6] |
PM2.5 | The inhalable particles present in the air of size 2.5 micrometer or smaller are categorize as PM2.5. | [7] |
PM10 | The inhalable particles present in the air of size 10 micrometer or smaller are categorize as PM2.5. | [8] |
CO | It is a colorless, odorless dangerous gas present in the environment. It is a silent killer and mostly produced in low oxygen. | [9] |
CO2 | It is atmospheric gas essential for globe temperature balance but harmful at its high concentration. It is also colorless and 60% denser than air. | [10] |
NO | It is known as oxides of nitrogen and known to general public as laughing gas. | [11] |
NO2 | Oxides of nitrogen which enter into the environment from burning of fossil fuels. | [12] |
SO2 | Atmospheric gas which has pungent smell. It natural sources are volcanic eruption and anthropogenic are fossil fuel exhaust. | [13] |
VOC | Compounds of carbon and hydrogen which convert into vapor or gases phase and contaminate the surroundings are known as volatile organic compounds. | [14] |
Aliphatic Hydrocarbons | Compounds with sigma bonds and delocalized pi electrons between carbon atoms forming a circle. | [15] |
According to the above discussion it is clear that the study of air pollution monitoring, their impacts on biotic components and their control strategies are very necessary to discuss in the nut shell.
Figure 1 is showing the impacts of air pollution on Animals, Plants, Humans and Microbes.
Impact of air pollution on biotic components of the environment.
The effect of these pollutants on the plants, humans, animals and microbes are comprehensively discussed in the following Table 1.
Pollutants | Plants | Humans | Animals | Microbes |
---|---|---|---|---|
Reduce the pigments, enzymatic activity and respiration. Also block the pores in plant leaf [16, 17, 18]. | Enhance metals intake [19], damage the lining of nasal cavity and enhance secretions [20]. | Damage the DNA of animals and increase protein oxidative damage in obese rats [21]. | Decrease the diversity of bacteria at highly polluted dust [22]. | |
C4 plants are less beneficial than C3 plants under high CO2 environment [23] | Increase sleeping, blood circulation, heart beat when exposed to high CO2 [24, 25] | High concentration leads to Zn accumulation and tissue damage in fish [26]. | Elevated CO2 effect metabolism, cell structure and diversity of microbes [27]. | |
Leaf necrosis. Dwarfing and necrosis. 0.05 to 0.5 ppm of SO2 damage the Spanish and cucumber while apple, barley and wheat are most sensitive to SO2 [28]. | Small exposures causes cough while long exposures causes asthma [29, 30] | Reduce the sperm motility in rats alter the seminiferous tubules in testis [31] and higher exposure induces cardiovascular problems [32] | In the open air fumigation study minute quantity meaningfully reduced respiration in both pine and deciduous litter [33]. | |
It delays photosynthesis. Concentration of 100 ppm cause spotting to leaf and break down. Oxidative stress increased due to boost in deduced oxygen species [34] | Premature demises cause in humans [35], Long-term contact to NOx is projected to lay foundation of 2119 respiratory demises and 991 lung cancer demises [36]. | High level of protein damage was observed in tree sparrow when exposed to higher level of NO [37]. | Not Yet Studied, a strong research gap exists here. | |
Ozone causes foliar injury, reduce the stomatal conductance, enhance the foliar injury and ultimately decrease the plant total biomass [38] | Premature death is the major concern [39]. | Ozone exposure to mice evidence the enhance air passage way inflammatory cell infiltration and bronchial hyper-responsiveness as compared to control [40] | Significantly reduced the mold or yeasts in yoghurts ozonated for 60s. | |
Cause fragmentation of nucleus and mitochondria and mitochondrion, chloroplasts and grana collapse [42]. | White matter of left hemisphere reduced and related with slower information. Rapidity during intelligence testing [43]. | Consuming the contaminated see food with heavy metals, PAHs and TPHs which is potentially poisonous [44]. | Microbes are used mostly to remediate the site contaminated with PAHs. |
Effect of the pollutants.
Aerosols are classified into solid [SPM, Dust (PM2.5 and PM10)], liquid (fumes, mist, vapors) and gaseous (smokes, gases) particles. Air pollutants are categorize the matter which is suspended in the air like road dusts, fumes of chemicals, mists, smoke from different emissions), gaseous pollutants (gases and vapors) and odors producing reagents.
In this Table 2 the major monitoring devices with their technology is listed for detail review.
Sr. No | Device | Technology used with pollutant | Citation |
---|---|---|---|
1 | Portable Monitoring Device for indoor air Pollution | For humidity and temperature complementary metal-oxide semiconductor (CMOS) technology, particulate matter by Laser-based light scattering, volatile organic compounds by Metal oxide gas sensor, CO2 by Non-dispersive infrared (NDIR), CO by Amperometric gas sensor, light by Infrared-responding photodiode and sound by Electret microphone with amplifier. | [45] |
2 | Home Pollution Embedded System (HOPES) | Internet of thing (IOT) device which is the grouping of gas semiconductor devices and an Infrared particulate matter sensor. | [46] |
3 | IoT Based system of Solar Power Environmental Air Pollution and Water Quality Monitoring System | Cheap system for sensing of alcohol, benzene, CO2, and NH3. When it is connected it to Arduino then it is able to sense the gases, and provide readings in PPM (parts per million). | [47] |
4 | A raspberry Pi controlled cloud based air and sound pollution monitoring system with temperature and humidity sensing | It is based on four modules which are Module for monitoring Air Quality Index Monitoring, Module for detection of Sound, Module for Cloud-based Monitoring The Anomaly Notification Module | [48] |
5 | The Next Generation Air Pollution Monitoring System (TNGAPMS) | Static Sensor Network (SSN), Community Sensor Network (CSN) and Vehicle Sensor Network (VSN) based on the carriers of the sensors. | [49] |
6 | The Ozone Monitoring Instrument (OMI) | OMI is an ultraviolet/visible (UV/VIS) nadir solar backscatter spectrometer, used to measure UV irradiance, trace gases of tropo-spheric and strato-spheric chemistry. | [50] |
7 | Wireless distributed sensor networks | It is based on three metal oxides (MO) chemo-resistive sensors for O3, NO2 and TVOC, an optical (IR based) total (TSP) sensor, noise sensor and a dual semiconductor sensor for temperature and humidity (RH) measurement. | [51] |
8 | TEMPO | It measures the spectra required to recover O3, NO2, SO2, water vapors, ultraviolet radiation, and foliage properties. | [52] |
9 | Amperometric electrochemical gas sensors | It is used for the monitoring of inorganic gases | [53] |
Air pollutants monitoring devices along with technologies.
The burning of diesel causes emissions. These emissions contain toxic gases and particulate matter (PM). Due to which there is a need to control these gases and particulate. For particulate control the diesel particulate filter is used to bind the PM which mostly is the combination of soot particles and organic fraction (soluble). The one bad thing with this system is the accumulation of soot particles in the filter lowers the activity of filtration [54]. To control the particulate matter from commercial cooking three technologies are used. The technologies named as Control technologies (CT) 1, 2 and 3. CT2 is the removal of grease technology which is based on the boundary layer momentum theory. Particulate matter was the significant higher in base line (CT1) than CT2. CT3 technology is Electrostatic precipitator based and is use full to reduce the volatile organic compounds like acetaldehyde and formaldehyde produced during commercial cooking [55]. The efficiency of Electrostatic precipitators is reduced if the temperature of the flue gases increases. The low-low temperature EP (LLTESPs) is more effective in particulate matter removal in coal fired plants. This temperature can be control by using Wet flue gas desulfurization (WFGD) in ESP. The study was conducted to check the effectiveness of the LLTESPs and WFGD. The outlet samples indicate that the concentration of PM decreased with the decrease of temperature. The concentration of soluble ions like mainly SO4−2, Cl− and NH4+ decreases in the outlet of LLTESPs (0.3 to 0.8 mg/m3) with respect to WFGD because the addition of gypsum slurry in WFGD (4.7 to 0.8 mg/m3) [56]. Preventive measures have been taken by individuals to get rid of polluted air. The facemasks are most commonly used by the Chinese people during the extremely high days. The model showed that 100-point increase in air quality index increases 54.5% consumption of facemasks. 187 million dollars could be save if control on air pollution has been achieved and it can be used for the social welfare of the habitants [57]. To combat with the particulate pollution there is a need of the hour to control the emission sources of particulate pollution with improved technologies [58].
Catalysts were identified by BET, FTIR, SEM- EDX, XRD, XPS technologies [59]. A study revealed that ZnO–CuO created hetero-composites show selective CO detecting with T100 is in close vicinity to Topt to yield simultaneous CO detecting together with its 100% catalytic oxidation for detection devices. The initiated oxygen reacts immediately with adsorbed CO to provide desired CO detecting together with 100% CO oxidation [60]. Evidences showed that oxidative desorption of CO enhance if oxygen species are present. Fast slaking of platinum in water boost the oxidation by two processes. One of the processes is chemical oxidation by using molecular oxygen and other is Langmunir-Hinshel wood surface oxidation [61].
Oxides of sulfur (SOx) are produced and exhausted during the operations of petrochemical industry and cause harmful effects on environment. One of the technique is sulfur recovery unit (SRU) which is made up of Claus process for removal of huge amount of sulfur removal and afterward a tail gas treatment unit (TGTU) for the remaining H2S removal (SCOT process, Beavon sulfur removal (BSR) process, and Wellman-Lord process) and flue-gas desulfurization (FGD) processes (once-through or regenerable) [64]. Conversion of H2SO4 from SO2, which could be a great impact on reducing pollution [65]. Various approaches for controlling SO2 emissions include.
In this technique, SO2 is absorb by the slurry of an alkaline chemical reagent, and SO2 (g) is either converted to liquid or solid.
Chlorine emission control technologies are necessary to meet the low emission standards of the USEPA. A study showed that flue gases were samples and analyzed by different emission control technologies (Selective non catalytic reduction, Electrostatic precipitators and fabric filters) and found that 86.1% of chlorine is exhausted in the form of gas. HCl is found significant in samples. The exclusion efficiencies of total chloride are 15.6% by ESP and 19.0–19.7% by FFs, respectively [69].
An exhaust system is designed (patent) which has the ability to store NOx at temperature below 200° C and release the NOx above 200° C [70]. Rising trends of Nitrate aerosols were observed in china. The main cause is day time nitrate emissions. These can be controlled if the day time emissions of NH3 and O3 be under-control [71]. NOx emissions are very common from the burning of dried sewage sludge. It is studied that if the combustor physical and operation condition maintained than NOx emissions can be controlled about 75%. Further argued that moderate or intense low oxygen dilution is best suited option to reduce NOx with the cyclone type furnace [72]. Another study suggested that air staging can lead to higher reduction of NOx [73]. NOx can further be controlled from the diesel exhaust by controlling the temperature. It could be 90% less emission if the temperature is minimized. Flue gas treatment with ozone oxidation technology is used to remove NOx. Increase in solubility and bond breakage is the key to success for this technology [74]. The three leading stack gas treatment techniques for NO
Study showed that heavy metals show different fate. The control devices which are used in incinerators and other pollution control devices. Some heavy metals like cadmium and plumbum stick in fabric filter ash while chromium, copper and nickel were predominant in the ash present in bottom of the boiler. Zn was found at the bottom and in the ash of fabric filter with a ratio of 07: 03. Though, very minute Hg was found furnace ash, boiler, and SDR and fabric filter; most of Hg crossed through the fabric filter and occurred in an oxidized form. The wet scrubber showed high level control efficacy for mercury which is oxidized, and the addition of commercial stimulated carbon at a rate of 0.2 g/Sm3 resulted in 93.2% mercury removal efficiency [76]. One study revealed that, a high-gravity method using alkaline wastes, i.e., fly ash from petroleum coke, was planned for control of air pollution, containing NOX, CO2 and aerosols. Further reacted fly ash can be used for additional cementations material [77].
Odor pollution control is very important for industries and domestic processes because it also caused disputes among neighbors. There are many order producing compounds which includes, organic ammonia, mercaptans and sulfides. Organic and inorganic amines are also very common [78]. NH3 scrubbers are used. The modified scrubber contains two parts. One part use water to remove dust pollution and other part contain dilute acid solution for removal of ammonia and VOCs. Different acidic salts which include aluminum sulfate (alum), sodium bisulfate, potassium bisulfate, ferric chloride and ferric sulfate were found to work as well as strong acids (hydrochloric, phosphoric and sulfuric) for capturing NH3. This technique could result in the capture of a significant amount of the N lost. It also improves the environmental acceptance by the neighbors due to odor control [79].
The degradation of organic pollutants by using the natural force (microorganisms) to water and carbon-di-oxide is known as biodegradation (BD). In artificial technique heat is used but in BD microorganism were utilized. BD efficiently occur at optimum moisture conditions, If plenty of moisture is available than bacteria grow efficiently and BD process speedup and vice versa [80].
Anthropogenic accelerated atmospheric pollution is very much dangerous to biotic as well as abiotic factors of the environment. There are different air pollutants (PM2.5 and PM10, dust, NOx, Sox, CO, CO2, and VOCs) have different ways to cause damage to soil, plants, humans, and animals. Sometime this is even lethal for living things and cause pulmonary disorders to even cancers. As pollution is originated from all the anthropogenic activities like industrial processes, power generation and traffic vehicles and are part of economic externalities. These activities cannot be stopped but their life so there are many control technologies which minimize pollutants release into the atmosphere and save the biotic and abiotic components from damage.
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In vitro, chemicals such as drugs and pesticides have different cytotoxicity mechanisms such as destruction of cell membranes, prevention of protein synthesis, irreversible binding to receptors etc. In order to determine the cell death caused by these damages, there is a need for cheap, reliable and reproducible short-term cytotoxicity and cell viability assays. Cytotoxicity and cell viability assays are based on various cell functions. A broad spectrum of cytotoxicity assays is currently used in the fields of toxicology and pharmacology. There are different classifications for these assays: (i) dye exclusion assays; (ii) colorimetric assays; (iii) fluorometric assays; and (iv) luminometric assays. Choosing the appropriate method among these assays is important for obtaining accurate and reliable results. When selecting the cytotoxicity and cell viability assays to be used in the study, different parameters have to be considered such as the availability in the laboratory where the study is to be performed, test compounds, detection mechanism, specificity, and sensitivity. In this chapter, information will be given about in vitro cytotoxicity and viability assays, these assays will be classified and their advantages and disadvantages will be emphasized. The aim of this chapter is to guide the researcher interested in this subject to select the appropriate assay for their study.",book:{id:"6310",slug:"genotoxicity-a-predictable-risk-to-our-actual-world",title:"Genotoxicity",fullTitle:"Genotoxicity - A Predictable Risk to Our Actual World"},signatures:"Özlem Sultan Aslantürk",authors:[{id:"211212",title:"Dr.",name:"Özlem Sultan",middleName:null,surname:"Aslantürk",slug:"ozlem-sultan-aslanturk",fullName:"Özlem Sultan Aslantürk"}]},{id:"66259",doi:"10.5772/intechopen.85270",title:"Antioxidant Compounds and Their Antioxidant Mechanism",slug:"antioxidant-compounds-and-their-antioxidant-mechanism",totalDownloads:7403,totalCrossrefCites:49,totalDimensionsCites:125,abstract:"An antioxidant is a substance that at low concentrations delays or prevents oxidation of a substrate. Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. 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Among these heavy metals, a few have direct or indirect impact on the human body. Some of these heavy metals such as copper, cobalt, iron, nickel, magnesium, molybdenum, chromium, selenium, manganese and zinc have functional roles which are essential for various diverse physiological and biochemical activities in the body. However, some of these heavy metals in high doses can be harmful to the body while others such as cadmium, mercury, lead, chromium, silver, and arsenic in minute quantities have delirious effects in the body causing acute and chronic toxicities in humans. The focus of this chapter is to describe the various mechanism of intoxication of some selected heavy metals in humans along with their health effects. Therefore it aims to highlight on biochemical mechanisms of heavy metal intoxication which involves binding to proteins and enzymes, altering their activity and causing damage. 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Antioxidant compounds act through several chemical mechanisms: hydrogen atom transfer (HAT), single electron transfer (SET), and the ability to chelate transition metals. The importance of antioxidant mechanisms is to understand the biological meaning of antioxidants, their possible uses, their production by organic synthesis or biotechnological methods, or for the standardization of the determination of antioxidant activity. In general, antioxidant molecules can react either by multiple mechanisms or by a predominant mechanism. The chemical structure of the antioxidant substance allows understanding of the antioxidant reaction mechanism. This chapter reviews the in vitro antioxidant reaction mechanisms of organic compounds polyphenols, carotenoids, and vitamins C against free radicals (FR) and prooxidant compounds under diverse conditions, as well as the most commonly used methods to evaluate the antioxidant activity of these compounds according to the mechanism involved in the reaction with free radicals and the methods of in vitro antioxidant evaluation that are used frequently depending on the reaction mechanism of the antioxidant.",book:{id:"8008",slug:"antioxidants",title:"Antioxidants",fullTitle:"Antioxidants"},signatures:"Norma Francenia Santos-Sánchez, Raúl Salas-Coronado, Claudia Villanueva-Cañongo and Beatriz Hernández-Carlos",authors:[{id:"143354",title:"Dr.",name:"Raúl",middleName:null,surname:"Salas-Coronado",slug:"raul-salas-coronado",fullName:"Raúl Salas-Coronado"},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez"},{id:"193718",title:"Dr.",name:"Beatriz",middleName:null,surname:"Hernández-Carlos",slug:"beatriz-hernandez-carlos",fullName:"Beatriz Hernández-Carlos"},{id:"278133",title:"Dr.",name:"Claudia",middleName:null,surname:"Villanueva-Cañongo",slug:"claudia-villanueva-canongo",fullName:"Claudia Villanueva-Cañongo"}]},{id:"66742",title:"Introductory Chapter: Alkaloids - Their Importance in Nature and for Human Life",slug:"introductory-chapter-alkaloids-their-importance-in-nature-and-for-human-life",totalDownloads:3960,totalCrossrefCites:14,totalDimensionsCites:29,abstract:null,book:{id:"6828",slug:"alkaloids-their-importance-in-nature-and-human-life",title:"Alkaloids",fullTitle:"Alkaloids - Their Importance in Nature and Human Life"},signatures:"Joanna Kurek",authors:[{id:"214632",title:"Dr.",name:"Joanna",middleName:null,surname:"Kurek",slug:"joanna-kurek",fullName:"Joanna Kurek"}]}],onlineFirstChaptersFilter:{topicId:"19",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81382",title:"Therapeutic Inhibitors: Natural Product Options through Computer-Aided Drug Design",slug:"therapeutic-inhibitors-natural-product-options-through-computer-aided-drug-design",totalDownloads:1,totalDimensionsCites:0,doi:"10.5772/intechopen.104412",abstract:"Drug repurposing involves reusing an active pharmaceutical ingredient that is already in the market and drugs that were unsuccessful in their clinical phases of development for a new indication. It has numerous benefits in drug development. Therapeutic inhibitors are agents that could be of synthetic or natural source with the ability to trigger the down-regulation of an enzyme or protein, thereby inducing therapeutic effect(s). Researchers have embraced synthetic methods in searching for therapeutic molecules through structural activity relationships and other means in the past and recent times. Despite these synthetic drugs, the morbidity and mortality rate of ailment and disease affecting humanity remains overwhelming. Research has shown that solutions to these challenges can be attempted through drug repurposing. In the past, natural products in raw forms have been utilized in traditional, complementary medicine to manage and treat diseases and illnesses, as there are molecules in use today as drugs, which originated from plants and other natural sources. Studies on natural products have led to diverse natural product databases that can serve as a source of repurposing agents. There are also databases for protein and enzymes of human origin, which have an enormous role in the in-silico drug repurposing approach.",book:{id:"10881",title:"Drug Repurposing - Molecular Aspects and Therapeutic Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10881.jpg"},signatures:"InnocentMary IfedibaluChukwu Ejiofor, Christabel Chikodili Ekeomodi, Sharon Elomeme and MaryGeraldine Ebele Ejiofor"},{id:"81857",title:"Use of Oral Ketamine in Palliative Care",slug:"use-of-oral-ketamine-in-palliative-care",totalDownloads:7,totalDimensionsCites:0,doi:"10.5772/intechopen.104875",abstract:"Ketamine, an N-methyl-D-Aspartate receptor antagonist, has been used for more than 50 years. From its initial potential as an anesthetic drug, its use has increased in the fields of pain medicine, psychiatry, and palliative care. It is available in different formulations, of which oral use is promising due to its active metabolite, norketamine which reaches 2–3 times higher levels when administered orally in comparison with parenteral use. Oral use is also more feasible and easier to use in settings, where medical staff is not that present, such as home care or hospices. Oral solution of ketamine has not yet been officially licensed for use although there have been several reports which recommend its use in neuropathic pain, severe depression, airway obstruction, and anxiety. Palliative care is defined as total care for patients whose diseases do not respond to curative treatment. It encompasses good control of physical symptoms, and psychological, social and spiritual problems. Patients often experience pain, despite high doses of opioids, depression and anxiety, and dyspnea. Oral ketamine does not have the side effects of opioids therefore it represents a good alternative. It may also reduce the need for high opioid doses and be more suitable for patients who wish to avoid the necessary sedation.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Mateja Lopuh"},{id:"81811",title:"Environmental Pollution Originated by the Excessive Use of Agrochemicals in the Production of Granadilla (Passiflora ligularis) Oxapampa District, Pasco, Perú",slug:"environmental-pollution-originated-by-the-excessive-use-of-agrochemicals-in-the-production-of-granad",totalDownloads:5,totalDimensionsCites:0,doi:"10.5772/intechopen.104910",abstract:"The purpose of this research was to evaluate the environmental pollution originated by the excessive use of agrochemicals in the production of granadilla (Passiflora ligularis) in the Oxapampa district, Pasco – Peru. The crops of this fruit were chosen in the sectors named: Abra (Ab), Chacos (Ch), Quillazú (Qll), Acuzazú (Ac), Cañera (Ca), San Alberto (SA), Alto Río Pisco (ARP), and Paradise (Pa), where applying the nonexperimental and comparative design, the soil, water, and fruit samples were taken, which were analyzed in the specialized laboratory of the Faculty of Chemistry and Chemical Engineering, of the Universidad Nacional Mayor de San Marcos (UNMSM). A survey was also carried out by the farmers to form groups (ABC), and the results obtained were statistically analyzed by means of the comparative difference of concentration of heavy metals in three groups selected according to intensity of use of agrochemicals, which were between 0.26 and 0.36 mg of Cu/kg of fruit, between 0.001 and 0.003 mg of Cd and Pb/kg of fruit, between 0.0012 and 0.0006 mg As and Hg/kg of fruit, between 19 and 25 mg of Cu/kg of soil, between 0.02 and 0.08 mg of Cd and Pb/kg of soil, between 0.05 and 0.08 mg of As and Hg/kg of soil; between 1 and 1.12 mg of Cu/l of water, between 0.002 and 0.003 mg of Cd and Pb/l of water, between 0.002 and 0.005 mg of As and Hg/l of water; being observed high averages in some heavy metals and whose comparisons were not significant for As, Hg, Pb, Cd, Cu in fruits, soil, and water, and significant only the Cd in fruits and Hg in soils, concluding that there is a potential risk of toxicity due to ingestion of granadilla (P. ligularis).",book:{id:"11329",title:"The Toxicity of Environmental Pollutants",coverURL:"https://cdn.intechopen.com/books/images_new/11329.jpg"},signatures:"Benito Buendía Quispe and Raymundo Erazo Erazo"},{id:"81818",title:"Radiopharmaceutical Biodistribution and Dosimetry",slug:"radiopharmaceutical-biodistribution-and-dosimetry",totalDownloads:12,totalDimensionsCites:0,doi:"10.5772/intechopen.104917",abstract:"Nuclear medicine is a medical specialty, where diagnostic and or therapeutic radioisotopes are used to study the physiology of organs and the metabolism of various types of tumors. Pharmaceuticals labeled with radionuclides (radiopharmaceuticals) are studied at pre-clinical level before being used in humans. Animals (Rodents) are generally used to study the biokinetics of tracer in a group of predefined organs. The extrapolation of the results of these studies from animals to humans provides an estimate of the behavior of the radiopharmaceuticals and the irradiation delivered clinically. Nuclear Medicine is fundamentally based on Radiopharmaceuticals whose biodistribution in disease and healthy organ result in either images that are diagnostically useful or local irradiation of tissue that is therapeutically beneficial for treatment of tumors. In result, in most procedures the biodistribution is primarily dependent on clearance of the radiopharmaceuticals from the blood into organs, tissues or lesions. Radiation is harmful for living beings and hence radiation toxicity is required to assess for new radiopharmaceutical which can be calculated by following the methodology of Internal dose calculation. Basic principle of Internal dosimetry and calculation methodology are explained in this chapter.",book:{id:"11012",title:"Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy",coverURL:"https://cdn.intechopen.com/books/images_new/11012.jpg"},signatures:"Santosh Kumar Gupta and Venkatesh Rangarajan"},{id:"81739",title:"Machine Learning and Artificial Intelligence in Therapeutics and Drug Development Life Cycle",slug:"machine-learning-and-artificial-intelligence-in-therapeutics-and-drug-development-life-cycle",totalDownloads:16,totalDimensionsCites:0,doi:"10.5772/intechopen.104753",abstract:"In recent years, the pharmaceutical business has seen a considerable increase in data digitization. With digitization, however, comes the challenge of obtaining, analyzing, and applying knowledge to solve complex clinical problems. Artificial intelligence (AI), which entails a variety of advanced tools and networks that can mimic human intellect, can overcome such challenges with traditional pharmaceutical development. Artificial intelligence and machine learning have a vast role in therapeutic development, including the prediction of drug target and properties of small molecules. By predicting the 3D protein structure, AI techniques, such as Alpha Fold, can help with structure-based drug development. Machine learning algorithms have been utilized to anticipate the properties of small molecules based on their chemical structure. Many researches have shown the importance of using in silico predictive ADMET (absorption, distribution, metabolism, excretion, and toxicity) models to speed up the discovery of small compounds with enhanced efficacy, safety, and dosage. This chapter discusses various roles of these methods in the development of effective therapeutics.",book:{id:"11091",title:"Drug Development Life Cycle",coverURL:"https://cdn.intechopen.com/books/images_new/11091.jpg"},signatures:"Subhomoi Borkotoky, Amit Joshi, Vikas Kaushik and Anupam Nath Jha"},{id:"81722",title:"Ketamine for Chronic Pain",slug:"ketamine-for-chronic-pain",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104874",abstract:"The treatment of chronic pain is a chronic problem for many specialities. It is generally based on an approach with antidepressants, anti-epileptics and opioids as drugs of first choice. It has been worked by many different protocols. Ketamine, which is known as a good anaesthetic, has been used for chronic pain. When the pain has a neuropathic component, ketamine is a promising treatment for pain management. Ketamine: by inhibiting the N-methyl-D-aspartate receptor and having some other effects like enhancement of descending inhibition and anti-inflammatory effects at central sites, takes part in chronic pain management. Besides having analgesic effects, there are some concerns about the side effects of ketamine. Some psychedelic symptoms as hallucinations, memory defects, panic attacks, nausea and vomiting, somnolence, cardiovascular stimulation and sometimes hepatoxicity may be seen in patients. Ketamine is generally well-tolerated in clinical settings. Close monitoring of patients receiving ketamine should be mandatory in order to be aware of central nervous system, haemodynamic, renal and hepatic symptoms as well as abuse.",book:{id:"11036",title:"Ketamine Revisited - New Insights into NMDA Inhibitors",coverURL:"https://cdn.intechopen.com/books/images_new/11036.jpg"},signatures:"Cigdem Yildirim Guclu"}],onlineFirstChaptersTotal:80},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:288,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403",scope:"Artificial Intelligence (AI) is a rapidly developing multidisciplinary research area that aims to solve increasingly complex problems. In today's highly integrated world, AI promises to become a robust and powerful means for obtaining solutions to previously unsolvable problems. This Series is intended for researchers and students alike interested in this fascinating field and its many applications.",coverUrl:"https://cdn.intechopen.com/series/covers/14.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:9,editor:{id:"218714",title:"Prof.",name:"Andries",middleName:null,surname:"Engelbrecht",slug:"andries-engelbrecht",fullName:"Andries Engelbrecht",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRNR8QAO/Profile_Picture_1622640468300",biography:"Andries Engelbrecht received the Masters and PhD degrees in Computer Science from the University of Stellenbosch, South Africa, in 1994 and 1999 respectively. He is currently appointed as the Voigt Chair in Data Science in the Department of Industrial Engineering, with a joint appointment as Professor in the Computer Science Division, Stellenbosch University. Prior to his appointment at Stellenbosch University, he has been at the University of Pretoria, Department of Computer Science (1998-2018), where he was appointed as South Africa Research Chair in Artifical Intelligence (2007-2018), the head of the Department of Computer Science (2008-2017), and Director of the Institute for Big Data and Data Science (2017-2018). In addition to a number of research articles, he has written two books, Computational Intelligence: An Introduction and Fundamentals of Computational Swarm Intelligence.",institutionString:null,institution:{name:"Stellenbosch University",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:50,paginationItems:[{id:"81927",title:"Purinergic System in Immune Response",doi:"10.5772/intechopen.104485",signatures:"Yerly Magnolia Useche Salvador",slug:"purinergic-system-in-immune-response",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science and Technology from the Department of Chemistry, National University of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013. She relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the National Institute of Fundamental Studies from April 2013 to October 2016. She was a senior lecturer on a temporary basis at the Department of Food Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is currently Deputy Principal of the Australian College of Business and Technology – Kandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI) Ambassador to Sri Lanka.",institutionString:"Australian College of Business & Technology",institution:null}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. 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