Guided bone regeneration is a term used to describe the use of the barrier membranes to enhance complete osteogenesis by preventing the rapid ingrowth of fibroblasts into a bony defect and promoting the migration of osteogenic cells from adjacent bony edges or bone marrow into the defect in an unimpeded fashion. Hyaluronic acid (HA) is a glycosaminoglycan of the general formula (C14H22NO11)n and is an essential component of the extracellular matrix in connective tissue, which is found in abundance in the alveolar environment. The most important function of HA is its involvement in tissue healing and repair. It has been shown that HA stimulates cell proliferation, migration and angiogenesis, re-epithelialization and proliferation of basal keratinocytes and reduces collagen and scar tissue formation. This text presents our clinical experiences and outcomes following HA applications in various implant surgery procedures. According to our clinical outcomes, HA is a highly promising material for improving therapeutic outcomes for oral implantology.
Part of the book: A Textbook of Advanced Oral and Maxillofacial Surgery
Inadequate bone volume at the implant recipient site presents a clinical challenge for many dental practitioners. To overcome these problems, several approaches have been developed and are currently used, including bone grafting strategies and distraction osteogenesis. Mesenchymal stem cells (MSCs) have gained their popularity within the last two decades, with regard to promising clinical results in improving the bone architecture at the implant recipient site. The aim of this chapter was to briefly outline the accessibility properties, differentiation capacities, isolation, and characterization of MSCs with regard to optimizing bone volume in dental implantology. Additionally, potential benefits and pitfalls are discussed in comparison with the conventional bone augmentation techniques.
Part of the book: Mesenchymal Stem Cells