Leonardo de Azevedo Calderon

Oswaldo Cruz Foundation

Leonardo de Azevedo Calderon obtained a bachelor\'s degree and a doctorate in Biological Sciences from the University of Brasília (UnB), Brazil, in 2000 and 2004, respectively. He is a researcher in public health at the Oswaldo Cruz Foundation, lecturer in the Medicine Department, Federal University of Rondônia, Brazil, and head of the Center for the Study of Biomolecules Applied to Health. He has experience in the fields of biochemistry, molecular biophysics, and bioinformatics, working mainly in the prospection and development of new chemical entities with potentially useful activities in future therapies for leishmaniasis and malaria.

2books edited

3chapters authored

Latest work with IntechOpen by Leonardo de Azevedo Calderon

Leishmaniasis is a major global health challenge, affecting approximately 12 million of the poorest people in 100 countries. It is a deforming and fatal disease in the visceral form. Therapies for leishmaniasis are numerically restricted, basically consisting of the administration of miltefosine, pentavalent antimonials, amphotericin B, or pentamidine. This is an important vulnerability against therapy efficiency that must be overcome by the scientific community. This book discusses important aspects of the disease, such as treatment, epidemiology, and molecular and cell biology. The information contained herein is important for young researchers as they seek to develop safe and effective treatments for this neglected tropical disease.

Go to the book

Leishmaniasis General Aspects of a Stigmatized Disease Edited by Leonardo de Azevedo Calderon

By Leonardo de Azevedo Calderon and Rodrigo Guerino Stábeli

Part of the book: Changing Diversity in Changing Environment

Purification of Phospholipases A2 from American Snake Venoms

By Rodrigo G. Stábeli, Rodrigo Simões-Silva, Anderson M. Kayano, Gizeli S. Gimenez, Andrea A. Moura, Cleópatra A. S. Caldeira, Antonio Coutinho-Neto, Kayena D. Zaqueo, Juliana P. Zuliani, Leonardo A. Calderon and Andreimar M. Soares

Part of the book: Chromatography

Leishmaniasis: Molecular Aspects of Parasite Dimorphic Forms Life Cycle

By Natanael Endrew Souto Maior Torres Bonfim, Ana Lígia Barbour Scott and Leonardo de Azevedo Calderon

According to WHO, Leishmaniasis is a complex neglected disease caused by a protozoa parasite from over 20 Leishmania species transmitted by more than 90 sandfly species, showing three main forms: visceral, cutaneous, and mucocutaneous. The efficient prevention and control of leishmaniasis are very difficult to achieve, depending on the combination of different intervention strategies, usually resulting in failure. Additionally, the correct diagnostics require the combination of clinical signs with laboratory tests, and only a few therapeutical options are available for patients. To improve this scenario, greater efforts in research for control and treatment are needed. For this purpose, the study and understanding of the life cycle of Leishmania are mandatory for all researchers who intend to dedicate their careers to the different aspects of this important disease. In order to support beginning researchers in the study of leishmaniasis, we propose in this review an update in the current knowledge about the major molecular aspects involved in the development of dimorphic forms of Leishmania parasites that replicate in the gut of sandflies (promastigotes) and in mammalian cells (amastigotes) and the relationship with host’s immune system.

Part of the book: Leishmaniasis

Leonardo de Azevedo Calderon

Latest work with IntechOpen by Leonardo de Azevedo Calderon

Leishmaniasis

Books edited

Chromatography

Chapters authored

Related collaborators

Enrique Javier Carvajal Barriga

Akihiro Ohnishi

Corrado Fogher

De Leon

Matteo Busconi

Serena Reggi

Giuliano Dallolio

Akihiro Nagano

Naoshi Fujimoto

Masaharu Suzuki