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Sadia Sultan

Universiti Teknologi MARAMalaysia

Dr. Sadia Sultan is an Associate Professor of Pharmaceutical Chemistry in the Department of Pharmacology and Chemistry at the Faculty of Pharmacy University Technology, MARA UiTM, Malaysia. She received her PhD Degree in 2004. Then, she worked as a chemist in the QA department of Abbot Lab, Pakistan. In June 2006, she was appointed Lecturer in the Faculty of Pharmacy, UiTM Shah Alam and a fellow of Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns). She has 15 years of experience in the field of Natural Product Research. Her areas of expertise include the following: biotransformation of exogenous substrates using microorganisms and plant tissue culture technique, exploring bioactive secondary metabolites from Plant, Soil and Marine Endophytic fungi (using Dereplication and OSMAC Approach), and biological screening using antimicrobial assays. She is the author of many e-books and chapters, and overall more than 40 publications. For her research works, she has been awarded several national grants as a principal investigator, including e-Science (Ministry of Science and Technology-MOSTI). Her research findings have also been recognized at several conferences, competitions and exhibitions and awarded with several awards.

1books edited

2chapters authored

Latest work with IntechOpen by Sadia Sultan

This book is specially written for researchers at various levels, for example, in forestry, agriculture, industry, university and college laboratories. It describes the fungal pathogenicity; resistance behavior of fungal biofilms and its mechanisms; different categories of fungal infection and colonization patterns with example relevant to soybean; characteristics of white rob of corncob and head smut of maize such as cycle, pathogenicity factors, control methods, the abilities of chitosan and its derivatives to elicit resistance reactions in plants and its action in the production and viability of fungal spores; and the mode of actions of single constituents of different essential oils depending on different case studies. In addition, this book also describes the importance of synthetic peptides as an alternative tool for the diagnosis of cryptococcosis. Finally, a survey of fungal diseases occurring on trees of Namibia is described. This survey is the first dedicated step to find ways of protecting them from disease-causing agents.

Fungal PathogenicityEdited by Sadia Sultan

Fungal Pathogenicity

Edited by Sadia Sultan

Chapters authored

Bioactive Polyesters in Marine and Plant Endophytic Fungi

By Sadia Sultan

Part of the book: Polyester

Molecular Docking Studies of Enzyme Inhibitors and Cytotoxic Chemical Entities

By Sadia Sultan, Gurmeet Kaur Surindar Singh, Kamran Ashraf and Muhammad Ashraf

Docking is a powerful approach to perform virtual screening on large library of compounds, rank the conformations using a scoring function, and propose structural hypotheses of how the ligands inhibit the target, which is invaluable in lead optimization. Using experimentally proven active compounds, detailed docking studies were performed to determine the mechanism of molecular interaction and its binding mode in the active site of the modeled yeast α-glucosidase and human intestinal maltase-glucoamylase. All active ligands were found to have greater binding affinity with the yeast α-glucosidase as compared to that of human homologs, intestinal, and pancreatic maltase, by an average value of ~−1.3 and ~−0.8 kcal/mol, respectively. Thirty quinoline derivatives have been synthesized and evaluated against β-glucuronidase inhibitory potential. Twenty-four analogs, which showed outstanding β-glucuronidase activity, have IC50 values ranging between 2.11 ± 0.05 and 46.14 ± 0.95 μM than standard D-saccharic acid 1,4-lactone (IC50 = 48.4 ± 1.25 μM). Structure activity relationship and the interaction of the active compounds and enzyme active site with the help of docking studies were established. In addition, Small series of morpholine hydrazones synthesized to form morpholine hydrazones scaffold. The in vitro anti-cancer potential of all these compounds were checked against human cancer cell lines such as HepG2 (Human hepatocellular liver carcinoma) and MCF-7 (Human breast adenocarcinoma). Molecular docking studies were also performed to understand the binding interaction.

Part of the book: Molecular Docking

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