The versatile DNA G-quadruplex structure has emerged as an interesting alternative reporter system applied in different biosensor platforms. In comparison to the conventional reporter systems like enzymatic or fluorescent, DNA G-quadruplex has some distinct advantages, as it is thermostable, easy to produce, low cost and most importantly able to be amplified. Such remarkable advantages have led many researchers to exploit DNA G-quadruplex as the reporter system in colorimetric, fluorescence and luminescence sensors. There has also been integration of DNA G-quadruplex with electrochemical methods and quantum dot for sensing applications. Therefore, this chapter highlights some recent examples of different biosensor platforms that use DNA G-quadruplex as a reporter system with different detection methods.
Part of the book: Nucleic Acids