Malaria drug discovery is a challenging and difficult task due to the unavailability of the vaccine and lack of newer drugs. The most potent artemisinin and its derivatives, widely used in combination therapies for curing malaria worldwide are also now falling to resistance in some parts of the world. Thus, to combat malaria, new drugs possessing high therapeutic value, minimal toxicity, rapid efficacy and low cost are urgently needed. In this chapter, we will provide an integrated overview on the challenges and opportunities in malaria drug discovery with more emphasis on synthesis of peroxidic antimalarials.
Part of the book: An Overview of Tropical Diseases
Tremendous efforts have been put toward the design and synthesis of newer enantioselective organocatalysts for the enanatioselective synthesis. Recently, guanidine-containing chiral organocatalysts have attracted considerable attention due to their ease of synthesis and high enantioselective catalytic activities. This chapter highlights the successive development of chiral guanidine organocatalysts in asymmetric organic transformation reactions in the past few decades.
Part of the book: Recent Advances in Organocatalysis