",isbn:"978-1-80356-963-5",printIsbn:"978-1-80356-962-8",pdfIsbn:"978-1-80356-964-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"8eeb7ab232fa8d5c723b61e0da251857",bookSignature:"Dr. Soumen Dhara and Dr. Gorachand Dutta",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11513.jpg",keywords:"Fabrication Technologies, Applications, Characterizations, Case Studies, Various Gas Sensors, Improvement of Lifestyle, Societal Benefit, Bio-Sensors, Bioreceptor Molecules, Integration, Packaging, Lab-on-Chip",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 8th 2022",dateEndSecondStepPublish:"June 17th 2022",dateEndThirdStepPublish:"August 16th 2022",dateEndFourthStepPublish:"November 4th 2022",dateEndFifthStepPublish:"January 3rd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in nanowire heterostructures and laser spectroscopy, recipient of JSPS (Govt. of Japan) and NPDF (Govt. of India) fellowships, and member of MRS(USA), MRS(India), IPA(India).",coeditorOneBiosketch:"Assistant Professor with the School of Medical Science and Technology, Indian Institute of Technology Kharagpur with research interests that include the design and characterization of portable biosensors, biodevices, and sensor interfaces for miniaturized systems and biomedical applications for point-of-care testing.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"196334",title:"Dr.",name:"Soumen",middleName:null,surname:"Dhara",slug:"soumen-dhara",fullName:"Soumen Dhara",profilePictureURL:"https://mts.intechopen.com/storage/users/196334/images/system/196334.jpeg",biography:"Dr. Dhara received his Ph. D in Physics in 2012 from Indian Institute of Technology Guwahati, India. Presently, he is associated with the Faculty of Science, Sri Sri University, India as an Assistant Professor in Physics. Prior to joining the current\naffiliation, he was a postdoctoral fellow at different renowned institutions, Kobe University Japan, S. N. Bose National Centre for Basic Sciences, India and Cardiff University, United Kingdom. He was awarded prestigious JSPS postdoctoral fellowship based on his research contribution on semiconducting nanowires. He has published more than 32 research articles including 1 review article in high profile international journals and 3 book chapters to his credit. 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His research interests include the design and characterization of portable\r\nbiosensors, biodevices and sensor interfaces for miniaturized systems and biomedical applications for point-of-care testing. He received his Ph.D in Biosensor and Electrochemistry from Pusan National University, South Korea,\r\nwhere he developed different class of electrochemical sensors and studied the electrochemical properties of gold, platinum, and palladium based metal electrodes. He completed his Post-doctoral fellowships in the Department of\r\nMechanical Engineering, Michigan State University, USA and Department of Electronic and Electrical Engineering at University of Bath, UK. 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1. Introduction
1.1 Free radicals
Free radicals are chemical species such as atoms or group of atoms with an odd (unpaired) number of electrons. They are produced due to splitting weak bonds. The biological free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), are usually produced in our bodies. It is known that free radicals are very reactive and may quickly react with other chemical entities (atoms or molecules) by capturing the required electron to gain stability. There are two types of biologically important reactive species. The first type contains oxygen and is known as reactive oxygen species (ROS), while the second type contains nitrogen and is known as reactive nitrogen species (RNS). Both ROS and RNS can be classified into radicals and non-radical species.
1.1.1 Reactive oxygen species (ROS)
ROS can be classified into two types, radical species and non-radical species. The most important ROS radicals are: superoxide anion radical (O2.–), hydroxyl radical (.OH), alkoxyl radical (RO.), lipid peroxide radical (ROO.), and hydroperoxy radical (HOO.). While the non-radicals ROS are: hydrogen peroxide (H2O2), singlet oxygen (1O2), ozone (O3), organic peroxide (ROOH), and hypochlorous acid (HOCl).
1.1.1.1 Superoxide anion radical
It is important to emphasize that the mitochondria is the main source of the most active biological ROS [1, 2, 3, 4, 5] such as superoxide anion radical (O2.−), hydrogen peroxide (H2O2) and hydroxyl radical (.OH). Thus, the initial reactive oxygen species (O2.−) is produced due to the reduction of free oxygen by some electrons leaking out from the electron transport chain during the process of oxidative phosphorylation. This particle is relatively stable intermediate and considered as the precursor for most important ROS. The reduction of free oxygen by electrons in mitochondria can be illustrated as follows: O2 + e− → O2.−. In addition, the superoxide anion radical may be produced in a process of oxygen reduction by enzymatic systems in mammalian cells as follows [6]:
The superoxide anion radical and hydrogen peroxide are formed in vivo, in the brain, and the central nervous system (CNS). It is known that several areas in the brain contain high amount of iron which stimulates free radical reactions.
1.1.1.2 Hydroxyl radical (.OH)
The superoxide anion and hydrogen peroxide can be converted rapidly to hydroxyl radical (.OH), which is known as the most reactive and destructive radical in biological system. This radical is quickly produced via Fenton [7] and Haber-Wiess reactions as follows [8, 9]:
H2O2+Fe2+→O.H+OH−+Fe3+FentonreactionE2
O2.−+H2O2→O.H+−OH+O2Haber−WeissreactionE3
The reaction of H2O2 with Fe+2 and Cu+ metal ions which are typically complexed with certain intracellular proteins such as ferritin and ceruloplasmin, respectively [7], occurs due to stress conditions, which means an excess of superoxide anion radical (O2.−). This phenomenon releases free ions (Fe+2) from ferritin which in turn reacts with H2O2 according to Fenton reaction to produce hydroxyl radical (.OH). This free radical can strongly react with biomolecules such as DNA, proteins, lipids, and carbohydrates and cause severe damage to the cells than any other ROS [10]. The. OH is the most destructive free radical and can more easily penetrate the phospholipid bilayer than O2.−, which is negatively charged. When ·OH is generated by Fenton reaction, the extent of its formation is largely determined by the availability and location of the metal ion catalyst. One feature of ·OH is that it leads to the generation of another radical, so when it reacts with a molecule, a new free radical is generated. However, the new free radical usually has lower reactivity than the hydroxyl radical (·OH). The ·OH attacks all proteins, DNA, polyunsaturated fatty acids (PUFA) in membranes, and almost any biological molecule it encounters [10]. The hydroxyl radical (·OH) can be obtained by another reaction in neutrophils, where HOCl reacts with superoxide anion radical [11, 12] as follows:
HOCl+O2.−→O.H+O2+Cl−E4
The hydroxyl radical (.OH) is the strongest oxidant produced in biological systems. It reacts very rapidly and indiscriminately with most biological targets present at its site of formation.
1.1.1.3 Lipid peroxide radical (ROO.) and alkoxyl radical (RO.)
Peroxy radicals (ROO.) and alkoxy radicals (RO.) are moderately strong oxidants. Lipid peroxidation starts with abstraction of H-atom by .OH, or by RO. to form alkyl radical (R.), then oxygen (O2) is added to alkyl radical to generate peroxyl radical (ROO.). Lipid peroxidation or the oxidative destruction of PUFA containing methylene groups (-CH2-) comprise the main targets [13]. This process can be illustrated in three steps as follows:
RH+.OH→R.+H2OInitiationstepE5
R.+O2→ROO.E6
Then, peroxyl radical reacts with another polyunsaturated fatty acid (RH) to remove H-atom:
RH+ROO.→R.+ROOHPropagationstepE7
Finally, to terminate lipid peroxidation, the following reaction takes place:
ROO.+ROO.→ROH+RO.+1O2TerminationstepE8
It is clear that lipid peroxidation leads to the formation of alkyl (R.), peroxyl (ROO.), and alkoxyl (RO.) radicals. Generally, lipid hydroperoxide (ROOH) is relatively stable, but in the presence of Fe and Cu ions, it causes the formation of alkoxy and peroxy radicals [14, 15].
ROOH+Fe3+→RO.+Fe2+E9
ROOH+Fe2+→ROO.+Fe3+E10
The reactivity of RO. and ROO. is related to the presence of substituents at the α-carbon. As a result, the presence of an electron-withdrawing group increases the reactivity, while the presence of an electron-donating group decreases it. Thus, aromatic ROO. and RO. must be less reactive because of single electron delocalization. These free radicals react with biomolecules by abstracting H-atom [16, 17].
1.1.1.4 Hydroperoxyl radical (HOO.)
Hydroperoxyl radical, also known as perhydroxyl radical (HOO.), is formed due to the reversible reaction occurring between superoxide anion radical and proton. This reaction takes place in cells as follows:
O2•−+H+↔HOO•E11
The pKa of this radical is 4.88 [18]. At pH 7.2 in the cytoplasm, a small amount of this radical (1% of O2•−) exists as HOO. [19]. Perhaps for this reason, many researchers presumed that HOO• has little or no role in initiation of lipid peroxidation [20]. In comparison with other oxidants, HOO• shows high specificity in reaction with PUFA, linoleic (C18:2), and linolenic (C18:3) acids [21].
1.1.2 Non-radicals of ROS
1.1.2.1 Singlet oxygen
The singlet oxygen (1O2) is a potent oxidizing agent, because it can react with different macromolecules such as DNA [22], and is responsible for lipid peroxidation of membrane and other tissues [23]. It is generated in cells, specifically in neutrophils and eosinophils [24, 23]. In addition, this particle can be formed by enzymatic reactions [25, 26, 27]. This reactive particle is produced due to the activation of molecular oxygen to two excited states. In the first excited state, oxygen has two electrons with opposite spins in the same ᴨ* orbital, while in the second excited state oxygen has one electron in each of two degenerate ᴨ* orbitals. However, singlet oxygen in the first excited state is extremely reactive in comparison with other excited states like the triplet state. Allen [28] suggested the mechanism for the production of singlet oxygen from H2O2 and Cl− in the presence of the myeloperoxidase (MPO) enzyme as follows:
H2O2+H++Cl−+MPO→HOCl+H2OE12
H2O2+HOCl→H2O+H++Cl−+O21E13
1.1.2.2 Hydrogen peroxide (H2O2)
Hydrogen peroxide is generated via an enzymatic reaction where the reactive superoxide anion radical is rapidly converted by an antioxidant enzyme called superoxide dismutase (SOD). The new formed oxygen species H2O2 is less reactive. Thus, hydrogen peroxide is formed as follows by SOD:
2O2.−+2H++SOD→H2O2+H2OE14
It is clear that, in the dismutation reaction (an oxidation–reduction process), two superoxide anion radicals are involved. In this reaction, one superoxide anion radical is oxidized to oxygen while the other is reduced to hydrogen peroxide [29]. The latter (H2O2) is relatively stable and membrane permeable so this non-radical species can diffuse inside the cell and can be removed by mitochondrial antioxidant enzymatic systems such as catalase (CAT) and glutathione peroxidase (GPx) [30, 31].
2H2O2+cat→O2+2H2OE15
2H2O2+2GSH+GPx→GSSG+2H2OE16
As illustrated, glutathione peroxidase (GPx) removes hydrogen peroxide (H2O2) by oxidizing two glutathione molecules (GSH) to produce oxidized glutathione disulfide (GSSG). It is clear that the three SOD, CAT, and GPx enzymes show synergistic effect in the scavenging of superoxide anion radical (O2˙−). The in vivo destruction effects of hydrogen peroxide (H2O2) result due to the presence of transition metals or enzymes, such as heme-peroxidase. The destruction of H2O2 leads to the formation of other more reactive oxidants such as.OH, NO., and HOCl. Thus, reaction of hydrogen peroxide with Cu1+ and Fe2+ leads to the production of. OH. On the other hand, in phagocytic cells, myeloperoxidase uses its substrate H2O2 to generate HOCl. The release of MPO during phagocytosis may play an important role in microbial elimination [32].
1.1.2.3 Ozone (O3)
Ozone gas (O3) exists in polluted atmosphere and the inhalation of this gas by human may lead to lung injury and inflammation. In living organisms, ozone is thought to be formed due to oxidation of H2O to H2O2 in the presence of antibodies [33]. Thus, antibodies use H2O as an electron source, facilitating its addition to 1O2 to generate dihydrogen trioxide (H2O3), which is converted to ozone [34].
H2O+1O2→HOOOH→O3+H2O2E17
Ozone reacts with fatty acids, cholesterol, amino acids and DNA. The lung is the most affected organ due to exposure to ozone. The effect of ozone on tissues occurs via free radical mechanisms [35, 36, 37]. The ozone radical anion then reacts with a proton to form the hydroxyl radical and oxygen as follows [36].
O3.−+H+→HO.+O2E18
1.1.2.4 Hypochlorous acid (HOCl)
This species (HOCl) is generated in neutrophils by the reaction of Cl − with H2O2, which is catalyzed by the enzyme myeloperoxidase [38]. It is illustrated as follows:
H2O2+Cl−+MPO→HOCl+O.HE19
The hypochlorous acid is considered to be a very reactive oxidizing agent. So, it may affect different biomolecules and may destroy phagocytized pathogens by causing oxidative damage to their biomolecules which include proteins [39], DNA [40], and lipids [41]. On the other hand, the overproduction of HOCl can lead to many health problems such as atherosclerosis and cancer [42, 38].
1.1.3 Reactive nitrogen species (RNS)
Reactive nitrogen species (RNS) can be found in biological systems as free radical species and non-radical species. However, the most common RNS radical is nitric oxide radical (NO.) and nitrogen dioxide (NO2). On the other side, the important non-radical RNS is peroxynitrite ion (ONOO−). Generations of these reactive species is discussed below.
1.1.3.1 Nitric oxide (NO .)
Nitric oxide free radical (NO.) is an endogenous free radical synthesized in the presence of nitric oxide synthase (NOS) that oxidizes L-arginine to L-citrulline [43]. In this reaction, one of the guanidino nitrogen atoms is oxidized to form NO.. This process is shown below:
L−Arginine+O2+NADPH+NOS→L−Citrullin+NO.+NADP+E20
The NO. radical can diffuse easily and has the ability to reach many intracellular targets and cause biological damage [44]. The enzyme nitric oxide synthase (NOS) is found in different cells such as vascular endothelial cells, smooth muscle cells, platelets, neuronal cells, macrophages, and neutrophils [45]. In addition, this radical plays an important role in biological tissues such as vasodilation, memory, neuronal response, among others [46, 47, 48, 49, 50].
1.1.3.2 Peroxynitrite (OONO−) and Other Reactive Nitrogen Species
This nitrogenous species is generated due to reaction of superoxide anion radical (O2−.) with nitrogen oxide radical (NO.) radical as follows:
O2−.+NO.→ONOO−E21
It is noted that at physiological pH (7.4), peroxynitrite exists in equilibrium with peroxynitrous acid, ONOOH [51].
ONOO−+H+↔ONOOHE22
Then, peroxynitrous acid (ONOOH) is subjected to homolysis to produce hydroxyl radical (OH•) and nitrogen dioxide radical (NO2.), which may rearrange to form nitrate (NO3−).
ONOO−+H+↔ONOOH↔HO.+NO2.→NO3−+H+E23
The ONOO− is a very reactive anion, even more so than the particle (NO. and O2•−) from which it is formed [52, 53, 54]. The peroxynitrite anion can cross biological membranes and interact with most critical biomolecules [55]. Thus, it can cause oxidation of lipids, and proteins via oxidation of methionine and tyrosine residues and can oxidize DNA to generate nitroguanine [56]. Under most biological conditions, ONOO- and ONOOH exist in equilibrium [57]:
ONOO−+H+↔ONOOHE24
Indeed, protonation weakens the O–O bond in ONOOH and leads to homolytic cleavage to generate hydroxyl radicals (.OH) and nitrogen dioxide (.NO2), two strongly oxidizing/hydroxylating and nitrating species, respectively.
ONOOH→.NO2+.OHE25
As a nucleophile, a central reaction of peroxynitrite in biology is the addition of the anion to carbon dioxide (CO2) to yield a nitrosoperoxocarboxylate adduct (ONOOCO2) that undergoes fast homolysis to NO2 and [58, 59, 60].
ONOO−+CO2→ONOOCO2−→N.O2+CO3−E26
1.2 Antioxidants
An antioxidant is any substance that has the ability to prevent, inhibit, or delay the oxidation of other substances. In biological systems, antioxidants play a very important roles in removing free radicals such as ROS and RNS, and consequently reduce oxidative stress. Antioxidant molecules can be classified based on the type of mechanistic defense they offer:
1.2.1 Antioxidants suppressing formation of free radicals
These are endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). These enzymes efficiently suppress or prevent the formation of free radicals and other ROS in tissues. Thus, SOD removes superoxide anion radical as follows:
2O2.−+2H++SOD→H2O2+H2OE27
On the other hand, CAT reduces formed H2O2 to water and oxygen:
2H2O2+cat→O2+2H2OE28
The GPx enzyme system detoxifies H2O2 by catalyzing its reduction using glutathione (GSH) as a sacrificial reductant to produce one molecule of oxidized glutathione (GSSG). Thus, the enzymes SOD, CAT, and GPx, work collectively to prevent the effect of O2˙−.
2H2O2+2GSH+GPx→GSSG+2H2OE29
In addition, Fe and Cu ions are included to this type of defense, since these ions bind proteins such as transferrin and caeruloplasmin and prevent them from free radical formation. Generally, any chemical compound having two or more of the following functional groups: –OH, –SH, –COOH, –PO3H2, C=O, –NR2, –S– and –O– may have chelating activity [61]. The mechanism of metal ion chelation with some natural phenolics such as protocatechuic acid and anthocyanins is shown in Figure 1.
Figure 1.
Mechanism of metal ion chelation with some natural phenolics.
Transition metal ions (Fe+2 and Cu+) make complex species with different types of phenolic compounds such as flavonoids containing multiple hydroxyl groups (polyhydroxylated). The involvement of these ions in the formation of complexes prevents the Fenton reaction which leads to the formation of hydroxyl radical (.OH) which is considered as the most dangerous ROS.
H2O2+M+n→HO−+HO.+Mn+1M=FeorCuE30
1.2.2 Antioxidants that repair damage resulting from the action of free radicals
This type of antioxidants are enzymes which are involved in repairing damage due to the effects of free radicals on biomolecules (DNA, proteins, lipids and carbohydrates). These enzymes prevent the accumulation of toxic substances resulting from destruction of biomolecules in body tissues. Examples of this type of enzymatic antioxidants include the DNA repair enzyme systems (polymerases, glycosylases and nucleases), and proteolytic enzymes (proteinases, proteases and peptidases) located in both, cytosol and mitochondria of mammalian cells.
1.2.3 Antioxidants that utilize signals for the formation of free radicals
This type of antioxidants use the signals, which are required for the formation of free radicals. As a result, the signal generated from the formed free radical causes the formation and transport of the appropriate antioxidant to the appropriate and required site [62].
1.2.4 Antioxidants scavenging free radicals
This type of scavenging antioxidants can directly neutralize free radicals by two mechanisms, either by donating a hydrogen free radical (H.) or donating an electron (e−). These mechanisms can be illustrated as follows:
Ar−OH+R.→Ar−O.+RHE31
In the preceding mechanism, the antioxidant donates a hydrogen free radical (H.) to scavenge free radicals, and the antioxidant (Ar-OH) itself becomes a free radical, though not as biologically harmful.
Ar−OH+R.→Ar−OH+.+R−→Ar−O.+H+E32
The second mechanism involves one-electron transfer where the antioxidant donates an electron to the free radical and becomes itself a radical cation. Generally, the new radicals are more stable and can be easily neutralized and made completely harmless and removed easily from biological systems. Many antioxidants such as ascorbic acid, uric acid, glutathione, vitamin E, and other natural compounds like polyhydroxyphenolic compounds belong to this class. This type of antioxidants are usually small molecules containing hydroxyl groups either of natural or synthetic origin. The importance of these compounds prompted us to review them in details.
2. Small antioxidant molecules containing hydroxyl groups
There are many studies that have shown the biological effectiveness of phenolic compounds as natural antioxidants. They play very important roles in the prevention of dangerous diseases such as cancers, heart diseases, diabetes and others. There is a need for simple molecules capable of neutralizing free radicals responsible for what is known as oxidative stress, the lead cause of dangerous diseases like cancers, heart disease, diabetes and others. Antioxidants play a critical role in biological systems in getting rid of free radicals and work to prevent the phenomenon of oxidative stress. The most available natural antioxidants exist in plants such as fruits, vegetables, and medicinal plants. Herein, we present an overview of the natural and synthetic phenolic compounds acting as antioxidants.
2.1 Natural antioxidants containing hydroxyl groups
2.1.1 Phenols
Simple phenols are known as compounds containing at least one hydroxyl group attached to an aromatic ring which comprises the basic skeleton. The most important compounds under this class are: phenol, catechol, resorcinol, and phloroglucinol. Generally, phenols are widely distributed in plants and play very important roles in human health because of their ability to neutralize free radicals due to their hydroxyl groups. It is considered that these simple phenols along with other phenolic compounds can inhibit and prevent cancer diseases in humans (Figure 2) [63].
The study by Spiegel et al. [64] has shown that the most active of simple natural phenols as antioxidants were those containing more than one hydroxyl group in the ortho position of the aromatic ring. This suggests that the most active antioxidant compound is catechol since it contains two hydroxyl groups in the ortho position. This could be attributed to the bond dissociation energy (BDE) of O-H which is typically used to evaluate the activity of an antioxidant to neutralize free radicals [65, 66, 67]. Thus, the weaker the O-H BDE, the faster the reaction of antioxidant with the free radical. In other words, the weaker the BDE of O-H in phenols, the easier it will be to transfer an H-radical to deactivate the free radical. The antioxidant activity of catechol and hydroquinone is illustrated as shown in Figure 3.
Figure 3.
Mechanism of action of natural phenolic antioxidants by transfer of hydrogen free radical (H•).
2.1.2 Phenolic acids: hydroxybenzoic and hydroxycinnamic acids
Phenolic acids are also known as phenol carboxylic acids (Figure 4). There are two important groups of natural phenolic acids which are hydroxybenzoic acids and hydroxycinnamic acids. These are derived from benzoic and cinnamic acid, respectively. The molecular structural features of phenolic acids, such as the numbers and positions of the hydroxyl groups in relation to the carboxyl functional group, esterification, and glycosylation great impacts their antioxidant properties. Many studies [68, 69] have shown that the antioxidant activity of phenolic acids and their esters was enhanced substantially when the number of hydroxyl (-OH) and methoxy (-OCH3) groups increased. On the other hand, the carboxyl group has an electron withdrawing effect, making the H-atom less available to be donated. However, the antioxidant activity of hydroxylated cinnamates are greater than that of benzoates [70, 71, 72]. The antioxidant activities of different hydroxybenzoic acids such as 4-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, and 3,4,5-trihydroxybenzoic acid were shown to be dependent on the number and position of attached hydroxyl groups to the aromatic ring [73]. Based on bond dissociation energy of O-H group, the dihydroxybenzoic acid has greater antioxidant activity than monohydroxybenzoic acid. It was observed that the BDE for -OH at 3-position is greater than the BDE of -OH at 4-position, as a result the abstraction of H-atom from the 4-position becomes easier than abstraction from the 3-position. Thus, it can be concluded that in 3,4-dihydroxybenzoic acid, the ability to abstract H-atom from the 4-position is easier than the 3-position. On the other hand, gallic acid (3,4,5-trihydroxybenzoic acid) showed lower antioxidant activity than that of 3,4-dihydroxybenzoic acid. This phenomenon could be attributed to the formation of a weak intramolecular H-bond between the -OH at 4-position and -OH at 5-position [74]. The obtained theoretical BDE of the -OH groups in gallic acid were in the order 4-OH ≤ 5-OH ˂ 3-OH, which indicates that the removal of H-atom is easier from 4-OH and 5-OH. Both of these values in gallic acid become lower than that of 4-hydroxybenzoic acid. Thus, the introduction of two hydroxyl groups at 3-position and 5-position significantly increases the antioxidant activity [73].
Figure 4.
Benzoic acid and the related hydroxybenzoic acids.
Similarly, the antioxidant activities of hydroxycinnamic acids (Figure 5) are related to their hydroxyl groups. The study of relationship between antioxidant activities and structures of hydroxycinnamic acids was carried out by Chen and Ho [74]. The BDE value of O-H group is a good indicator to evaluate the antioxidant activity of an antioxidant. Thus, the weaker the O-H bond, the greater the ability of an antioxidant to neutralize free radicals. In addition, phenolic molecules bearing two hydroxyl groups in o-position relative to one another showed high antioxidant activities [75, 76, 77] as observed with caffeic acid. On the other hand, replacement of one hydroxyl group by methoxy group as in ferulic acid leads to lower antioxidant activity [65, 66, 67, 75, 76, 77, 78, 79, 80]. Therefore, the BDE value of O-H would be expected to follow the following order: caffeic acid ˂ ferulic acid ˂ p-coumaric acid. As a result, the antioxidant activities of these acids will be in the order: caffeic acid ˃ ferulic acid ˃ p-coumaric acid. However, it is important to remember that the removal of H-atom from caffeic acid could arise from m-OH and p-OH to form free radicals. Consequently, the resulting free radical due to removal of the H-atom from p-OH would be more stable because of resonance where the electron is delocalized over the whole molecule, but in the case of removal of the H-atom from m-OH, the unpaired electron cannot be delocalized over the whole molecule since it cannot cross the propenoic tether [81].
Figure 5.
Cinnamic acid and hydroxycinnamic acids.
2.1.3 Flavonoids
The flavonoids consist of a large group of low-molecular weight polyphenolic substances, benzo-γ-pyrone derivatives (Figure 5). The basic structural feature of all flavonoids is the flavane (2-phenyl-benzo-γ-pyran) nucleus, a system of two benzene rings (A and B) linked by an oxygen-containing pyran ring (C). According to the degree of oxidation of the C ring, the hydroxylation pattern of the nucleus, and the substituent at carbon 3, flavonoids can be categorized into the following subclasses: flavones, isoflavones, flavanols (catechins), flavonols, flavanones, anthocyanins, and proanthocyanidins. Flavonols differ from flavanones by a hydroxyl group at the C3 position and by a C2–C3 double bond. Anthocyanidins differ from the other flavonoids by possessing a charged oxygen atom in the C ring (Table 1).
Table 1.
Types of flavonoids.
Flavonoids are secondary metabolites and mainly distributed in the plant kingdom such as green and black tea, coffee, vegetables, fruits, olive oil, red wine, white wines, and chocolate [82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92]. They are consumed in milligrams per serving of these plant sources. Many researchers have shown that flavonoids possess different biological activities which include vasodilating, anti-allergenic, antiviral, and anti-inflammatory actions [93, 94, 95]. However, the antioxidant activity of these compounds attracted the most interest because, in addition to their ability to scavenge free radicals, they also reduce or prevent free radical formation.
The capability of antioxidant activities of flavonoids is mainly related to their chemical structures. Many previous investigations attributed the high antioxidant activities of these compounds to the presence and positions of hydroxyl groups attached to the A and B rings and/or to the C2 = C3 double bond in conjugation with the carbonyl group at 4-position, and the -OH group at 3-position [93, 94, 96]. On the other hand, the replacement of hydrogen atom by a saccharide at 3-position to form a glycosidic bond, the antioxidant activity decreases. The radical scavenging efficiency of flavonoids is related to their phenolic hydroxyl groups which follow the mechanism of H-atom transfer or the single electron transfer followed by sequential electron transfer-proton transfer (SETPT) [97, 98, 99, 100]. As in the case of phenolic acids, the antioxidant activity of flavonoids, is based on the value of the dissociation energy of the O-H bond [67, 97, 101]. The study by Quan et al. [102] showed that the dissociation energy of C-H at 3-position in some flavonoids appeared to be lower than that of the dissociation energy of O-H. As a result, the antioxidant activity might be due the donation of H-atom from C-H at 3-position. However, the mechanism of antioxidant activity via H-atom transfer from the -OH group appeared to be the most significant [102]. Generally, flavonoids as antioxidants may act by different mechanisms such as hydrogen atom transfer, single electron transfer, and transition metal chelation. These mechanisms are shown below in Figures 6–9. Figure 6 shows the proposed mechanism of radical scavenging activity of cyanidin by Nimse and Palb [103] following HAT mechanism.
Figure 6.
Proposed mechanism of radical scavenging activity of cyanidin by Nimse and Palb [103].
Figure 7.
Proposed mechanism of superoxide anion radical scavenging activity of quercetin by Nimse and Palb [103].
Figure 8.
Proposed mechanism of single electron transfer by Leopoldini et al. [104].
Figure 9.
Proposed metal–quercetin chelation by Leopoldinia et al. [104].
2.1.3.1 -Hydrogen atom transfer (HAT)
The flavonoid quercetin is found in many plants and foods and in notable quantities especially in onions, red wine, green tea, apples, berries, and others. The proposed mechanism of superoxide anion radical scavenging activity of quercetin by Nimse and Palb [103] is shown in Figure 7.
The proposed mechanism of single electron transfer by Leopoldini et al. [104] for single electron transfer (SET) and transition metal chelation (TMC) are shown in Figures 8 and 9.
2.1.3.2 Single electron transfer (SET)
2.1.3.3 Transition metal chelation (TMC)
Flavonoids with their multiple hydroxyl groups and the carbonyl group at the 4 position on ring C may offer several available sites for metal chelation. The ability of flavonoids to chelate Fe and Cu ions is related to their indirect antioxidant activities. This property of flavonoids is attributed to their multiple hydroxyl groups and the carbonyl group at 4-position [104].
2.1.4 Stilbenes
The Stilbene family includes several compounds [105] among which resveratrol, pterostilbene, and piceatannol are the main representatives, characterized by a trans double bond connecting the phenolic rings (Figure 10).
Figure 10.
Stilbene and its related polyphenolic derivatives.
Stilbene compounds are part of a group of natural polyphenols occurring in plant kingdom such as grapes [106], peanuts [107], and berries [108]. Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene), which is found in grapes, showed different biological activities including antidiabetic, antiobesity, and neuroprotective properties against Alzheimer’s disease (AD) [109]. In addition, other stilbenes have shown additional activities as antimicrobials and antioxidants [110]. Different studies have shown that piceatannol (4′, 5′, 3, 5-tetrahydroxystilbene) expresses a wide spectrum of biological activities: anti-inflammatory, anticarcinogenic, antiviral, antioxidative, neuroprotective and estrogenic properties, and antioxidant activities [111, 112, 113, 114, 115, 116, 117]. A study by Hussein [118] demonstrated the strong ability of resveratrol to scavenge free radicals using different tests. The mechanism of antioxidant activity of resveratrol was proposed to be as follows (Figure 11).
Figure 11.
Proposed mechanism of resveratrol antioxidant activity [118].
2.2 Synthetic antioxidants containing hydroxyl groups
Synthetic antioxidants are usually used as food preservatives to prevent lipid oxidation [119]. The well-known synthetic antioxidants are butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and t-butyl-hydroxyquinone (TBHQ). These antioxidants stop the free radical chain of oxidative reactions via the donation of an H-atom radical from the phenolic -OH attached to the aromatic rings (Figure 12). The new formed radicals become stable and do not initiate or propagate further oxidation of lipids [120].
Figure 12.
Antioxidant action of t-butyl-hydroxyquinone as a radical terminator via the donation of a hydrogen radical and subsequent radical delocalization by resonance.
The progressively more sterically hindered BHT and the related BHA operated as radical terminators in a similar fashion to TBHQ (Figure 13).
Figure 13.
Oxidation of BHT and BHA via donation of a hydrogen radical from a phenolic hydroxyl group.
Another type of radical quencher is shown in Figure 14 where the generated phenoxy radical is stabilized by intramolecular hydrogen bond.
Figure 14.
Generation of a phenoxy radical with intramolecular hydrogen bond shown.
The presence of a bulky group introduces steric hindrance in proximity to the radical center, decreasing the rate of further propagation reactions. Another example which illustrates the increase in antioxidant activity is the presence of an extra hydroxyl group at the ortho or para position of the hydroxyl group of phenol. The stability of the phenoxy radical in this case is enhanced by the formation of an intramolecular hydrogen bond. Other studies [121, 122, 123] described the synthesis of different compounds like aromatic Schiff bases and aromatic hydrazones containing hydroxyl groups attached to different positions in the aromatic rings. These compounds were designed to mimic as much as possible natural phenolic compounds such as stilbene and chalcones. The number of hydroxyl groups and their locations in the aromatic rings play an important role in the antioxidant activity. The mechanism of antioxidant activity can be illustrated as follows and involves the donation of hydrogen radical (Figure 15).
Figure 15.
Proposed mechanism for the action of aromatic hydrazones via H radical donation.
3. Oxidative stress
Oxidative stress is a phenomenon occurring in living systems and is related to the presence of free radicals (oxidants) and antioxidants (reductants). When we talk about free radicals in biological systems, we mean two types: reactive oxygen species (ROS) and reactive nitrogen species (RNS). Imbalance between free radicals and antioxidants (endogenous and exogenous) in biological systems creates a state know as oxidative stress. In this case, the present antioxidants cannot remove the ROS and RNS from living species. As a result, excess free radicals can negatively impact different biological processes, leading to the destruction of cell membrane, blocking pathways of major enzymes, stopping cell division, destruction of DNA, and halting energy production [124, 125, 126]. On the other hand, free radicals appear to be necessary for some processes in living organisms since they destroy bacteria by phagocytes (granulocytes and macrophages). In addition, ROS can be beneficial for the maintenance of homeostasis as well as other cellular functions [125, 127]. Again, it is important to remember that the primary free radicals are superoxide anion radicals O2. − and hydroxyl radical. OH which are derived from molecular oxygen (O2). High levels of these radicals may cause different biological problems which may lead to cancer, stroke (Reuter et al., 2010) [126], myocardial infarction, diabetes, and other significant conditions [128].
It is not easy to avoid the exposure of free radicals and consequently oxidative stress. However, the increase of consumption of natural antioxidants through diet may help to decrease the production of free radicals. In other words, to prevent oxidative stress, it is highly recommended to consume enough amounts of vegetables, fruits, medicinal plants, and honey to ensure sufficient supplementation of natural antioxidants [129, 130, 131, 132, 133].
4. Conclusion
To maintain normal health and avoid incurable diseases such as cardiovascular disease, cancer diseases, diabetes, among other, it is necessary to protect the existing balance between free radicals and antioxidants in biological systems. Naturally the human body has means of internal defense to neutralize free radicals. These means of defense are represented by a group of biological molecules known as antioxidant enzymes. In addition, there are a number of small molecules such as urea, bilirubin, vitamin E, vitamin A, and others. These simple molecules play a positive role in eliminating free radicals. However, when the internal system fails to get rid of free radicals, a supply of external antioxidants, especially those from natural sources, is needed to remove excess free radicals. There are many antioxidants in nature especially those that contain hydroxyl groups such as phenolic compounds, such as phenolic acids (derivatives of hydroxybenzoic and hydroxy cinnamic acids), flavonoids, stilbenes, chalcones and others. These compounds are found in fruits, vegetables and medicinal herbs. There are some chemically prepared antioxidants in laboratories which use is almost limited to the food and pharmaceutical industries. However, there are many attempts to manufacture antioxidants that mimic those found in nature, especially those containing hydroxyl groups, in the hope of obtaining compounds at the lowest cost, safe to use, and in large quantities.
Acknowledgments
Dr. Ziad Moussa is grateful to the United Arab Emirates University (UAEU) of Al-Ain and to the Research Office for supporting the research developed in his laboratory (Grant no. G00003291/Fund no.31S401/Project #852).
\n',keywords:"antioxidants, hydroxyl Groups, natural antioxidants, synthetic antioxidants, small-molecules antioxidants",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/74790.pdf",chapterXML:"https://mts.intechopen.com/source/xml/74790.xml",downloadPdfUrl:"/chapter/pdf-download/74790",previewPdfUrl:"/chapter/pdf-preview/74790",totalDownloads:576,totalViews:0,totalCrossrefCites:3,totalDimensionsCites:5,totalAltmetricsMentions:0,introChapter:null,impactScore:1,impactScorePercentile:47,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"October 8th 2020",dateReviewed:"December 22nd 2020",datePrePublished:"January 13th 2021",datePublished:"September 8th 2021",dateFinished:"January 13th 2021",readingETA:"0",abstract:"Polyhydroxylated natural phenolic compounds, especially those with low molecular weights, are characterized by their ability to eliminate free radicals as they act as strong antioxidants. The various types of phenolic compounds represent the most important natural antioxidants in addition to some vitamins. The chemical structures of these compounds is discussed in details with their action mechanisms to remove free radicals and prevent many incurable and malignant diseases. In addition to these natural compounds, the last two decades have witnessed increased attempts by many scientific groups and research centers to synthesize chemical compounds in large quantities to mimic these natural compounds, but at a lower cost and greater biological effectiveness. Herein, we conduct a chemical survey of relevant synthetic compounds containing the hydroxyl groups prepared in chemical laboratories and studied for their biological efficacies, such as their effectiveness as antioxidants, as well as the mechanism of elimination of free radicals.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/74790",risUrl:"/chapter/ris/74790",book:{id:"10544",slug:"antioxidants-benefits-sources-mechanisms-of-action"},signatures:"Mohammed Ali Al-Mamary and Ziad Moussa",authors:[{id:"300774",title:"Dr.",name:"Ziad",middleName:null,surname:"Moussa",fullName:"Ziad Moussa",slug:"ziad-moussa",email:"zmoussa@uaeu.ac.ae",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"United Arab Emirates University",institutionURL:null,country:{name:"United Arab Emirates"}}},{id:"335205",title:"Dr.",name:"Mohammed Ali",middleName:null,surname:"Al-Mamary",fullName:"Mohammed Ali Al-Mamary",slug:"mohammed-ali-al-mamary",email:"almamarym@hotmail.com",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Taibah University",institutionURL:null,country:{name:"Saudi Arabia"}}}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Free radicals",level:"2"},{id:"sec_1_3",title:"1.1.1 Reactive oxygen species (ROS)",level:"3"},{id:"sec_1_4",title:"1.1.1.1 Superoxide anion radical",level:"4"},{id:"sec_2_4",title:"1.1.1.2 Hydroxyl radical (.OH)",level:"4"},{id:"sec_3_4",title:"1.1.1.3 Lipid peroxide radical (ROO.) and alkoxyl radical (RO.)",level:"4"},{id:"sec_4_4",title:"1.1.1.4 Hydroperoxyl radical (HOO.)",level:"4"},{id:"sec_6_3",title:"1.1.2 Non-radicals of ROS",level:"3"},{id:"sec_6_4",title:"1.1.2.1 Singlet oxygen",level:"4"},{id:"sec_7_4",title:"1.1.2.2 Hydrogen peroxide (H2O2)",level:"4"},{id:"sec_8_4",title:"1.1.2.3 Ozone (O3)",level:"4"},{id:"sec_9_4",title:"1.1.2.4 Hypochlorous acid (HOCl)",level:"4"},{id:"sec_11_3",title:"1.1.3 Reactive nitrogen species (RNS)",level:"3"},{id:"sec_11_4",title:"1.1.3.1 Nitric oxide (NO .)",level:"4"},{id:"sec_12_4",title:"1.1.3.2 Peroxynitrite (OONO−) and Other Reactive Nitrogen Species",level:"4"},{id:"sec_15_2",title:"1.2 Antioxidants",level:"2"},{id:"sec_15_3",title:"1.2.1 Antioxidants suppressing formation of free radicals",level:"3"},{id:"sec_16_3",title:"1.2.2 Antioxidants that repair damage resulting from the action of free radicals",level:"3"},{id:"sec_17_3",title:"1.2.3 Antioxidants that utilize signals for the formation of free radicals",level:"3"},{id:"sec_18_3",title:"1.2.4 Antioxidants scavenging free radicals",level:"3"},{id:"sec_21",title:"2. Small antioxidant molecules containing hydroxyl groups",level:"1"},{id:"sec_21_2",title:"2.1 Natural antioxidants containing hydroxyl groups",level:"2"},{id:"sec_21_3",title:"2.1.1 Phenols",level:"3"},{id:"sec_22_3",title:"2.1.2 Phenolic acids: hydroxybenzoic and hydroxycinnamic acids",level:"3"},{id:"sec_23_3",title:"Table 1.",level:"3"},{id:"sec_23_4",title:"2.1.3.1 -Hydrogen atom transfer (HAT)",level:"4"},{id:"sec_24_4",title:"2.1.3.2 Single electron transfer (SET)",level:"4"},{id:"sec_25_4",title:"2.1.3.3 Transition metal chelation (TMC)",level:"4"},{id:"sec_27_3",title:"2.1.4 Stilbenes",level:"3"},{id:"sec_29_2",title:"2.2 Synthetic antioxidants containing hydroxyl groups",level:"2"},{id:"sec_31",title:"3. Oxidative stress",level:"1"},{id:"sec_32",title:"4. Conclusion",level:"1"},{id:"sec_33",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'Li X, Fang P, Mai J, Choi ET, Wang H, Yang XF. 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Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radical Biology and Medicine. 2006; 41 (12): 1727-1746, 2006. doi: 10.2174/1381612054065783'},{id:"B132",body:'Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, Müller MJ, Oberritter H, Schulze M, Stehle P, Watzl B. Critical review: vegetables and fruit in the prevention of chronic diseases,European Journal of Nutrition. 2012; 51 (6): 637-663. doi: 10.1007/s00394-012-0380-y'},{id:"B133",body:'Crowe FL, Roddam AW, T. J. Key TJ et al. Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. European Heart Journal. 2011; 32 (10):1235-1243. doi: 10.1093/eurheartj/ehq465'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Mohammed Ali Al-Mamary",address:null,affiliation:'
Department of Chemistry, Faculty of Applied Science, Taiz University, Republic of Yemen
Department of Chemistry, College of Science, United Arab Emirates University, United Arab Emirates
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1. Introduction
Expeditious expansion and industrial development near the rivers have led to more stress on the river, and with increased stress, the water becomes polluted, and worsening environmental health is observed [1]. The water-soil interface and the water-atmosphere interface are the medium through which the heavy metals travel [2, 3]. Both anthropogenic activities and geochemical processes are responsible for heavy metal contamination in ecosystems [4]. Elements that have high density and are less noxious are known as heavy metals. Examples of heavy metals are lead, iron, mercury, cadmium, zinc, arsenic, copper, and chromium and the actual volume of these heavy metals is more than 6 g/m3 [5]. Heavy metals have the property of environmental persistence and bioaccumulation, and these heavy metals enter the aquatic system through various routes. These heavy metals not only impair the quality of the aquatic ecosystem but also human health [6, 7]. These heavy metals can be found on the layer of earth in their regular form. These heavy metals are so dangerous that they cannot be degraded or decomposed and they have the arability to bioaccumulate [8]. These heavy metals once get into the ecosystem through the air, via drinkable water, or multiple chemicals and products that are manmade. The route of administration of these heavy metals is via inhalation, ingestion, and skin absorption. These heavy metals get into the biosphere via human activities, which include industrial production, mining, agriculture, and transportation [9]. Some methods are fossil fuel burning, smelting of different, waste from the municipality, fertilizers, pesticides, and sewage these all are considered to be the primary sources of metal pollution [10, 11, 12, 13]. The toxicity of these heavy metals in the human body reduces energy levels; disrupts brain functioning; disturbs the functioning of various other organs such as the brain, lungs, liver, and kidney; and also hinders blood composition. If the contact with heavy metals continues, then it can hinder the physical, neurological, and muscular functioning. And due to these diseases like multiple sclerosis, Parkinson’s disease and muscular dystrophy, and Alzheimer’s disease. Chronic exposure to some of the heavy metals and their compounds may even cause cancer [14]. Pollution of these heavy metals into the river may cause distressing effects on the ecological balance of the aquatic environment, and with the extent of contamination, the diversity of aquatic organisms becomes limited [15]. The fish in the aquatic ecosystem can be used for examining the well-being of biota. Due to pollutants in the food chain of organisms, harmful effects can be seen and the aquaculture can become dead [16]. These heavy metals are neurotoxins for the fish living in the aquatic environment. When these heavy metals enter the fish body, they interact with them to generate biochemical reaction inside the fish, which makes it difficult for fish to communicate with their surroundings [17]. The presence of these heavy metals leads to diseases like Minamata, which is organic mercury poisoning. When these heavy metals get bioaccumulated, they become a threat to both the human population and animals who uses that water [18]. Modeling of risk assessment is divided into four stages, i.e., exposure assessment, toxicity (dose-response) assessment, hazard identification, and risk characterization. There are three pathways through which humans get exposed to traced metals, which include directly ingesting, inhaling through the mouth or nose, and via skin absorption when it gets exposed. From the water, the heavy metals usually enter through ingestion and dermal absorption. To assess exposure, the average daily dose is measured for pollutants through different identified paths. In a dose-response assessment for no carcinogens, reference doses (RfD) are calculated, and for carcinogens, slope factors (SF) are obtained by the United States Environment Protection Agency (USEPA) Integrated Risk Information System (IRIS) database. With the help of the facts which are discussed above, there was a study done with an aim to evaluate the water quality of the Subarnarekha River relating to metals, their temporal classification, source of identification, and assessment of human health risk when that water was ingested or the contaminate when absorbed through the skin. Through this, it is possible to know the contamination level and accordingly, the strategies were planned (Table 1) [19, 20].
Heavy metal ions
WHO’s permissible limit (mg L−1)
Se
0.02
Hg
0.001
Mn
0.02
Ag
0.1
Cd
0.05
Cr
0.003
Pb
0.01
Zn
3.00
Fe
0.30
Cu
0.02
As
0.01
Table 1.
Permissible limit of heavy metal ions in water [21].
2. Source of contamination in water
The presence of these heavy metals on the surface of the water can be due to natural or anthropogenic activities. In natural activities, weathering of rocks that contain metals, an eruption from volcanos, fires in the forest, and naturally occurring processes of weathering can be included. From these activities, metal enters the different sections of the environment. Heavy metals can be found in the forms of sulfates, hydroxides, oxides, sulfides, phosphates, and silicates [12, 22]. A huge amount of accumulation of heavy metals into the water is mainly due to anthropogenic and natural activities. Some more examples of natural source through which heavy metals contaminates water are, wet and dry deposition of atmospheric salts, water-rock interaction, or water interaction with the soil. While the sudden increase in urbanization and industrialization are an example of anthropogenic sources through which water get contaminated (Table 2; Figure 1) [23].
Heavy metal ion
Common sources
Copper (Cu)
Fertilizers, tanning, and photovoltaic cells
Zinc (Zn)
Soldering, cosmetics, and pigments
Silver (Ag)
Refining of copper, gold, nickel, zinc, jewelry, and electroplating industries
Chromium (Cr)
Leather industry, tanning, and chrome plating industries
Arsenic (As)
Wooden electricity poles that are treated with arsenic-based preservatives, pesticides, fertilizers, the release of untreated effluents, oxidation of pyrite (FeS) and arsenopyrite (FeAsS)
Mercury (Hg)
Combustion of coal, municipal solid waste incineration, and volcanic emissions
Cadmium (Cd)
Paints, pigments, electroplated parts, batteries, plastics, synthetic rubber, photographic and engraving process, photoconductors, and photovoltaic cells
Lead (Pb)
PVC pipes in sanitation, agriculture, recycled PVC lead paints, jewelry, lead batteries, lunch boxes, etc.
Table 2.
Major sources of some heavy metal ions in water [24].
Figure 1.
Contamination of water through different sources.
2.1 Natural sources
Trace metals are found in excess levels in the environment, they are formed by geographical processes such as volcanic eruptions, weathering of rocks, and leaching into rivers, lakes, and oceans due to the action of water [25]. The presence of heavy metals in water depends on the local geology, hydrogeology, and geochemical characteristics of the aquifer [26]. One of the main sources of pollution is weathering. The weathering of the sedimentary rocks such as limestone or dolomite or shale makes the water contaminated or polluted. When there is an interaction of water with rock element, it also leads addition of these elements into the water; thus, contamination occurs. Examples of such elements are granite, syenite, basalt, gabbro, nepheline, and andesite. Due to the particular ore or the minerals, the element level increases. Elements examples are magnetite, hematite, goethite, siderite, calcite, cuprite, malachite, azurite, chromite, kaolinite, montmorillonite, arsenic trioxide, orpiment, arsenopyrite, calamine, smithsonite, pyrolusite, and rhodochrosite [27, 28, 29, 30]. The sulfide deposition also increases as it is associated with the mineralization of the gold and hydrous iron oxide ores [31].
2.2 Anthropogenic sources
Anthropogenic events, in which human settlement replaced the natural forest and agricultural activities have increased the environmental impacts. Such activities have contaminated the aquatic ecosystems, which include spring waters from the river like the Amala and Nyangores, tributaries of Mara River, Indonesia in Mau Complex. The maximum of forest land is converted into human settlement and agriculture. People who live near the Mara River Basin use that spring water for the purpose of animal and agricultural purposes [21]. The water carrying capacity has decreased with the rapid increase in industrialization and urbanization. Hg concentration in water has increased with agriculture activities and human activities. Activities like domestic sewage into the water, solid waste burning, coal and oil combustions, and pyrometallurgical processes and mining are the main reason for this. Water, by either snow or rain, brings the contaminated soil with Hg into the adjacent water areas [32, 33]. The source of Ni is the corroded metal pipes and containers [34]. The major source of lead in water majorly comes from additives of paints and petrol and aerosol precipitation, which is formed due to the high temperature used in industrial processes for the purpose of coal combustion, smelting, and cement production [35], and chloralkali, batteries, fluorescent lamps, thermometers, and electronic switches production. Chemical industries are some industrial activities through which Hg pollutes the water system and these activities are the largest contributor to Hg contamination in the environment [36].
2.3 Domestic sewage
Huge amount of untreated sewage from domestic is thrown into the river. This untreated waste from domestic has the presence of toxins. These toxins are due to the presence of solid waste or from the litter of plastic, or the contamination of bacteria due to the presence of these the water can get polluted. Domestic untreated water is thrown directly into the water resource and this majorly causes pollution inside the water and harms the ecosystem [37]. These pollutants majorly depend upon what kind of industry has thrown those pollutants. When these toxic metals get inside the water, they decrease the quality of the water [38]. Around 25% of pollution inside the water is caused only by these industries [39]. When the water gets contaminated, the water gets enriched by the nitrogen and phosphorous elements. With the presence of these nutrients, the growth rate of algae gets multiplied, and then it competed with the surrounding aquatic biota for the dissolved oxygen in water [40]. The presence of nitrite and nitrate anions leads to a major threat to the exposed organisms; examples of such threats are methemoglobinemia. It is more common in small children, and the symptoms caused by this are cyanotic color in the skin due to blood alterations [41]. Water sources that get deposited by this sewage also become anions rich, due to the presence of chlorine in urine, and NaCl is used in the human diet. On the side of the sea, there is the presence of chloride in high concentrations due to the leakage of salt into the sewerage system. It also may be increased by industrial processes [42].
2.4 Industrial source
Contamination of heavy metals in the aquatic environment is very harmful since these elements cannot be degraded and they get accumulated inside the living organisms [43]. Residue from the industry is the major source through which these heavy metals get into the aquatic ecosystems, and their accumulation in water varies with the type of wastewater treatment used [44]. Effects known as deleterious can be observed when the metal particles are introduced into the water system [45, 46]. Different metals from the Amazon River (Brazil) and the Yukon River (Alaska) were analyzed in the solid-state only. Plants have the presence of these metals in water. In tissue, the concentration of several metals is slow, and their concentration should be kept in less range only as more concentration can be harmful to the biological development of the pant [47]. Through the food chain, fish contaminants can reach man [48]. Effluent from industries, water tank leakages, dumping beside marines, and due to radioactive waste and atmospheric deposition, are some sources of water contamination. Disposed of heavy metals and waste from industries they get accumulated in rivers and lakes thus causing harmful impacts on animals and humans. For suppression of the immune, reproductive failure and acute poisoning toxins are responsible [49]. Then there is direct damage to plant or animal nutrition at that time human health is affected. The pollutants that are polluting the water are killing marine organisms such as mollusks, marine birds, fishes, and other organisms that live in the sea [50].
2.5 Urbanization
With an increase in the population has created many issues and one of the issues is the pollution of water [38]. An increase in the population leads automatically leads to more generations of solid waste [51]. Both solid waste and liquid waste are deposited into the water without any treatment. Human excreta also contaminate the water. Thus, contaminated water leads to a generation of a large number of bacteria, which is a threat to human well-being [39]. Government is unable to supply vital requirements to the People because of the increase in the number of people. Facility for sanitization is more in urban areas as compared to rural areas. Plastic bag and waste are a major contribution to pollution. People throw the waste in plastic bags into water sources [24]. From the research, it was found that around three crore people of the population defecate in the open, while 77% population use flush and around 8% use the pit latrines. Urbanization can cause many infectious diseases. Overpopulation, unhealthy conditions, and dangerous drinkable water are these major health problems in urban areas. One-third of urban people are vulnerable to disease [37].
2.6 Agriculture source
The population in rural areas is less but the use of fertilizers, pesticides, and eroded soil contaminates the water. When it rains the water from the surface runoff and that rainwater enters the nearby water resource and thus pollutes the existing water [52]. Agricultural runoff cases freshwater bodies’ eutrophication. Half of the lakes in the US are eutrophic. Phosphate has one of the major contributions to eutrophication. And the high concentration of phosphates promotes cyanobacteria and algae growth, which leads to the excessive use of the biologically dissolved oxygen inside the water [53]. Fertilizers that are too enriched with nitrogen decrease the dissolved oxygen in rivers and coastal zones thus bringing hazardous effects to the biota. Since 2006, the nitrogen in fertilizers is being controlled in America and Northwest Europe [54]. Like pesticides, which are used as pest control, these pesticides leach into groundwater, thus polluting groundwater. The pesticides that are water-soluble leach more and the sandy soil favors the process of leaching [55].
2.7 Atmospheric source
Small pollutants particles which are present in the air, get into the water stream through the rain, when it rains these particles come down and then with the flow of water enters into the sea, thus polluting the water there. These pollutants that are present in the air usually get from the burning of fossil fuels e.g. is CO2, which combines with water and produces sulfuric acid. Sulfur dioxide, which is formed via volcanic eruption and from industries, also gets attached to a water molecule to form the sulfuric acid. When coal is combusted then also sulfuric dioxide is produced and it is also produced from petroleum products. Just like this nitrogen dioxide also combines with the water and forms the nitric acid. And with the help of rainwater, they enter the water resources (Figure 2) [52, 56, 57, 58, 59].
Figure 2.
Circulation of contaminants between environmental sources under the effect of atmospheric sources.
2.8 Mining source
Heavy metals are present on the earth and thus they can enter the water system through various pathways and one of them is through mining sources. When it rains or through flowing water, it leaches heavy metals out from their geological formation. These processes get disturbed when manmade economic activities such as mining are done. Through these processes, the area that is already mined out gets exposed to water and air and this leads to the acid mine drainage (AMD). The low pH conditions associated with AMD mobilize heavy metals, including radionuclides where these are present [60].
2.9 Heavy metal intake through water
Soil gets polluted with the presence of heavy metal on surface and underground water and the pollution rises when mined ores are discarded on the ground surface for manual dressing [61]. Due to the dumping over the surface, the metals get exposed to air and rain thereby generating huge AMD. If soil is polluted at that time, it gets into the plant tissue and gets accumulated there. And when those plants are grazed by animals and water is used for the drink from polluted waters, through there these heavy metals enter the body. Also, marine lives, which reproduce in contaminated water, also have the presence of heavy metals inside their body tissues, if they are lactating then inside their milk. As an overview, all organisms within a given ecosystem are contaminated via these pollutants through their food chains [62]. When nutrition from these contaminated vegetables is taken, the presence of heavy metals in those vegetables can lead to different chronic diseases. Toxic effects due to these heavy metals usually depend on the amount of concentration and the oxidative state of the particular heavy metals [63]. Heavy metals have a very dangerous impact as they are non-biodegradable in nature, have long biological half-lives, and have the potential to accumulate inside the body. Also, there are some heavy metals that are extremely toxic only because of their solubility. Fewer concentrations of heavy metals inside the food chain also show severe effects as there is no particular procedure through which these heavy metals pollutants can be extracted from the body of an organism. Nowadays presence of these toxic heavy metals is everywhere because of their extreme use in industries. In case of the wastewater, it contains a huge concentration of heavy metals, which create various health-related problems [64, 65].
3. Effect on living organism
3.1 Effect on aquatic environment
Water from estuaries and freshwater is not polluted till now to some extent, but that water is also at threat of being polluted in the long term due to metal deposition because of human past activities [66]. The water in the river and lakes can be highly polluted depending on the volume of flow and proximity to the point sources. Due to the human civilization, the element content in water is raised. Such elements are cadmium, lead, mercury, zinc, and chromium. Unlike organic chemicals, there are some metals that cannot be converted into compounds with lesser toxicity, and one of its characteristics is the loss of biodegradability. Once the heavy metals enter the water system it gets redistributed throughout the column and gets accumulated in the sediments [67]. The sediments constitute a partial contribution to polluting the natural phenomena due to their activity and metal remobilization processes. Metal residues that are present in the contaminated surroundings have the flexibility to get bioaccumulated into the aquatic environment [68]. Growth in fish larvae and juveniles is rapid. But when these heavy metals enter they might inhibit the growth rate. The fish grows in length and bulk when given the right conditions, such as a specific temperature and an acceptable amount of food. Fish growth, on the other hand, may be impeded in water contaminated with toxicants, such as heavy metals. One of the most noticeable signs of metal toxicity in fish larvae is growth inhibition. As a result, the length and bulk of fish are indications of environmental conditions [69]. Heavy metals are introduced in liquid form and surface water constituents (carbonate, sulfate, organic substances humic, fulvic, and amino acids) cause the formation of non-soluble salts or complexes. Aquatic species are not expected to be harmed by these salts and compounds. Some of them sink and collect in the sediments at the bottom. A decrease in pH of water either due to acid rain or any other acidic incidents, due to the heavy metal’s deposition into the water column, causes aquatic biota to become poisonous. Low levels of heavy metals can also make chronic stress, through fish might not get dead but can cause them to lose weight and become smaller, reducing their capacity to compete for food and habitat [70]. Pollution poses a hazard to both freshwater and marine habitats. Heavy metal poisoning of water is a significant environmental hazard that has detrimental consequences for organisms who are exposed to it be that plant-animal or humans. Fish from freshwater are majorly exposed to various heavy metals, which are added into the water bodies through the different-different sources. Contamination of these heavy metals into aquaculture has intensified global issues because it shows a risk to fish and has harmful impacts on fish buyers [71]. There are three different modes through which heavy metals enter the fish. These methods are either through the gills of fish, by the body of the fish, or by the digestive tract of the fish. Heavy metals immediately enter the fish body through the gills, while the body surface takes time for uptaking of these heavy metals through this mode [72]. Mostly the metals get accumulated in the liver, kidney, and gills. In fishes, the muscles have most of the metals present there as compared to the other body parts of the fish. Too much accumulation of these heavy metals inside the fish organ can cause lesions and operative disturbances [73]. These heavy metals also interfered with the embryo’s shape and the metabolic processes of the fishes. Structural and functional defects throughout the development of the embryo resulted in fewer larvae hatching. Several freshly born larvae die shortly after hatching owing to lead and copper absorption [74, 75]. Heavy metals get into the fish through three routes: the first is via the fish gills, the second is through the digestive tract of the fish and the last one is through the body of the fish. The gills of fish are the area that is known for the primary metal intake from the contaminated water. On the fish gills, zinc accumulates. It suggests a depressing influence on tissue respiration, which leads to hypoxia and mortality. Zinc pollution also causes alterations in the structure of the lungs and heart [76]. Humans and fish are both affected by mercury. Brain damage, with postnatal and fetal problems, leads to abortions, congenital deformity, and development differences in young fry due to Monomethyl. Minamata illness and Hg poisoning (via methyl Hg) both showed considerable neurotoxicity [77]. Nickel is necessary for tiny amounts for the formation of RBC, but when its concentration gets increased, at that time, it becomes harmful or poisonous. Cd has been linked to an increase in blood pressure and cardiac illness in fish. Blood vessels damage, hemorrhages, and depletion of blood cell count of a fish are induced by Hg, from previous research. Anemia, eosinophilia, lymphocytosis, bronchial, and renal injuries can affect chromium levels in the blood [18]. Malformations in fish are caused by cadmium, nickel, mercury, chromium, lead, and arsenic. The accumulation of these heavy metals in excessive amounts causes a variety of physiological effects. Fin loss, gill underdevelopment, liver dysfunction, and fin function in fingerlings were all prevalent findings in the studies [78]. The harmful effects of heavy metals have the greatest impact on the death rate, reproduction, individual development rates, and physiological capacity of fish. There have been effects on physical functioning and chemical parameters in the tissues and blood of fish living in water that is polluted via metals. It has been reported that fish exposed to metals developed immune system defects, making them more susceptible to infectious infections and increasing their chances of dying (Figure 3) [79].
Figure 3.
Harmful effects on the aquatic environment.
3.2 Effects on aquatic plants
For the growth of plants, few HMs like As, Cd, Hg, Pb, and Se are not important as they do not perform any known physiological function in them. Others, such as Co, Cu, Fe, Mn, Mo, Ni, and Zn, are key elements that are required for regular plant development and metabolism, but their amounts can quickly exceed the appropriate levels, resulting in poisoning [80, 81]. Heavy metal concentrations in plants vary by plant species, and the efficiency with which various plants absorb metals is measured by plant absorption or metal transfer factors from soil to plant. An increased amount of Pb in agricultural soil decreases the productivity rate of the soil, and a less lead amount may hinder some important processes of plant, dark green leaves, withering of older leaves, stunted foliage, and brown short roots are poisonous indicators of photosynthesis, mitosis, and water absorption [82]. Heavy metals are poisonous and phytotoxic to plants, resulting in diseases such as chlorosis, poor plant development, and yield depression, as well as decreased nutrient absorption, plant metabolic problems, and a reduced capacity to fix molecular nitrogen in leguminous plants. Seed germination was gradually reduced in the presence of increasing levels of lead, it may be due to exposure to lead for a longer duration, some methods, such as leaching, chelation, metal binding, or microbe accumulation, have resulted in the neutralization of lead’s harmful effects [83]. Heavy metals such as Cd, Pb, and Ni even their small concentration in plants can be hazardous to them. Poisoning due to this heavy metal will result in the complex interplay between the primary unpleasant ions and additional necessary or non-essential ions. Metals affect the activity of enzymes by swapping metal ions from metal enzymes, as well as preventing plant growth [84]. Some exceptional metals are vital for plants, as they reveal their roles in the catabolism of plants and biosynthesis, together as cofactors for enzymes and as metabolic yields. For example, Zn, Fe, Cu, Cr, and Co are the important nutrients but when their amounts are increased, they become toxic. Comparatively, Pb and Cd have no effect, which is favorable to the plant and is solely lethal [85]. The most abundant hazardous elements in the soil are lead. Pb poisoning in the soil is caused by municipal sewage sludge discharge, mining and smelting operations, Pb-containing paints, paper and pulp, gasoline, and explosives. They do not have any role in the shape of the plant or their growth and photosynthetic process of the plant. Pb poisoning also inhibits enzyme action, creates an imbalance of the water, alters membrane permeability, and disrupts mineral feeding [86].
3.3 Effects on fish
One of the main sources of contamination of the water is heavy metals, as it overwhelms the important species indirectly through biological chains or directly via chemical modifications in water. Three potential ways are there, through which heavy metals get into the fish body: though fish gills, through the body of the fish, and through the fish digestive tract. Gills are responsible for the immediate absorption of metals from the water, whereas the body surface is thought to have a smaller role in the intake of these elements in fish [87]. By altering the normal activities of numerous enzymes and metabolites, the accumulation of these heavy metals in the tissues causes significant biochemical, physiological, and histological changes in fish and other freshwater fauna. Fish are one of the most widely dispersed creatures in the aquatic ecosystem, and their susceptibility to metal poisoning may indicate the extent of metal pollution’s biological impact [88]. Heavy metals, such as As, Cd, Cu, Cr, Fe, Pb, Mn, Hg, Ni, Zn, and tin (Sn), are major contaminants that cause serious toxicity in fish. Due to the heavy metals, the physiological and biochemical functions both in tissues and in blood Carpi can be altered. The compounds of As and inorganic As, Cd, Ni, silica in its crystal form, beryllium, and its compounds are considered to be chemical carcinogens, which results in the development of cancer inside the fishes. The drop in hematological parameters indicated that the exposed fishes had become anemic as a result of Cr exposure. This dangerous heavy metal was released into the aquatic ecosystem via trash, causing severe anemia and changes in hematological parameters in the Labeo rohita fish [89]. There are various studies on different fish such as Noemacheilus barbatulus, Perca fluviatilis, Catostomus commersonii, Oreochromis mossambicus, and Oreochromis aureus, and increased quantities of zinc, lead, cadmium, copper, mercury, and cadmium were found in the gonads of fish, according to the study. This causes contamination of eggs and sperm, as well as a reduction in fish fertility and embryonic development [90]. The number of hatched larvae was reduced due to anatomical and functional abnormalities during embryonic development. A percentage of freshly born larvae died shortly after hatching as a result of lead and copper absorption [75]. The sensitivity of heavy metals inhibits estrogenic and androgenic secretion and produces pathological differentiation in fish. The reproductive tissues of fish gonads are affected by effluents such as industrial and agricultural waste, pesticides, and heavy metals [91, 92]. Zinc gets accumulated over the gills of fish. It entails a depressing influence on tissue respiration, which leads to hypoxia and death. Zinc contamination also causes abnormalities in the structure of the ventilator and heart. Zinc is a toxicant that destroys gill tissue, disrupts acid–base and ion balance, and causes hypoxia in fish [93]. More importantly, heavy metal for neurotoxicity is Hg. While other factors play a role in neurotoxicity, mercury has a major impact on both fish and humans. Japan’s rivers have been contaminated with mercury. Minamata illness and Hg poisoning (via methyl Hg) both showed considerable neurotoxicity [77]. Arsenic coagulates proteins, binds to coenzymes, and reduces the production of adenosine triphosphate (ATP) during respiration. It can induce cancer in all of its oxidation states in combination, and high-level articulation can result in mortality. Carcinogenic metals such as cadmium, arsenic, nickel, and chromium [94] can damage DNA by deleting base pairs, mutating it, or attacking it with radical oxygen. Malformations in fish are caused by cadmium, nickel, mercury, chromium, lead, and arsenic. When the accumulation of these heavy metals gets excessive inside the water through this, many physical effects on fish can be seen. Fins get shortened; gills are underdeveloped; and liver and fin functions of fingerlings were commonly observed. The harmful effects of heavy metals have the greatest impact on the death rate, individual growth rates, reproduction, and physiological capacity of fish. The effects of metal pollution on physiological processes and biochemical parameters in the blood and tissue of fish have been studied. Fish that are exposed to heavy metals reveal faults in the immune system and thus are more exposed to diseases and chances of death increase [79].
4. Conclusion
Water pollution is a global problem, and the world’s population is suffering the consequences of tainted water. Living organisms are also affected by the polluted water very much and it is very harmful to the environment. Acute and choric illnesses are caused by heavy metal concentrations in drinking water that exceed the permissible limits set by several national and international organizations. These can range from nonfatal, such as muscle and physical weakness, to fatal, such as brain, nervous system, and even cancer. Water quality testing is necessary for the protection of human health and the environment.
\n',keywords:"heavy metal, water, toxicity, pollution, living organisms",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/82246.pdf",chapterXML:"https://mts.intechopen.com/source/xml/82246.xml",downloadPdfUrl:"/chapter/pdf-download/82246",previewPdfUrl:"/chapter/pdf-preview/82246",totalDownloads:85,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 2nd 2022",dateReviewed:"April 27th 2022",datePrePublished:"June 15th 2022",datePublished:null,dateFinished:"June 15th 2022",readingETA:"0",abstract:"Water has become a major threat in today’s world. Collection of heavy metals, a few of them, is potentially toxic and these get distributed to different areas through different pathways. With an increase in the earth’s population, development and industrialization are taking place rapidly and these get the major source of water contamination. With heavy metals in lakes, rivers, groundwater, and various water sources, water gets polluted by the increased concentration of heavy metals and metalloids through release from the suddenly mine tailings, disposal of high metal wastes, growing industrial areas, leaded gasoline and paints, usage of fertilizers inland, animal manures, E-waste, sewage sludge, pesticides, wastewater irrigation, coal, etc. Exposure to heavy metals has been linked to chronic and acute toxicity, which develops retardation; neurotoxicity can damage the kidneys, lead to the development of different cancers, damage the liver and lungs; bones can become fragile; and there are even chances of death in case of huge amount of exposure. This chapter mainly focuses on heavy metal pollution in water and its toxic effect on living organisms.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/82246",risUrl:"/chapter/ris/82246",signatures:"Anubhav Singh, Anuj Sharma, Rohit K. Verma, Rushikesh L. Chopade, Pritam P. Pandit, Varad Nagar, Vinay Aseri, Sumit K. Choudhary, Garima Awasthi, Kumud K. Awasthi and Mahipal S. Sankhla",book:{id:"11329",type:"book",title:"The Toxicity of Environmental Pollutants",subtitle:null,fullTitle:"The Toxicity of Environmental Pollutants",slug:null,publishedDate:null,bookSignature:"Dr. Daniel Dorta and Prof. Danielle Palma De Oliveira",coverURL:"https://cdn.intechopen.com/books/images_new/11329.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-580-5",printIsbn:"978-1-80355-579-9",pdfIsbn:"978-1-80355-581-2",isAvailableForWebshopOrdering:!0,editors:[{id:"172524",title:"Dr.",name:"Daniel",middleName:null,surname:"Dorta",slug:"daniel-dorta",fullName:"Daniel Dorta"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. Source of contamination in water",level:"1"},{id:"sec_2_2",title:"2.1 Natural sources",level:"2"},{id:"sec_3_2",title:"2.2 Anthropogenic sources",level:"2"},{id:"sec_4_2",title:"2.3 Domestic sewage",level:"2"},{id:"sec_5_2",title:"2.4 Industrial source",level:"2"},{id:"sec_6_2",title:"2.5 Urbanization",level:"2"},{id:"sec_7_2",title:"2.6 Agriculture source",level:"2"},{id:"sec_8_2",title:"2.7 Atmospheric source",level:"2"},{id:"sec_9_2",title:"2.8 Mining source",level:"2"},{id:"sec_10_2",title:"2.9 Heavy metal intake through water",level:"2"},{id:"sec_12",title:"3. Effect on living organism",level:"1"},{id:"sec_12_2",title:"3.1 Effect on aquatic environment",level:"2"},{id:"sec_13_2",title:"3.2 Effects on aquatic plants",level:"2"},{id:"sec_14_2",title:"3.3 Effects on fish",level:"2"},{id:"sec_16",title:"4. Conclusion",level:"1"}],chapterReferences:[{id:"B1",body:'Giri S, Singh AK. 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Such technology developments as the ones presented here undoubtedly shall be based on interdisciplinary projects involving not only rheology or fluid mechanics but several other disciplines. Three practical applications which use Rayleigh or Marangoni convection in their working principle are presented along with some technical details. This contribution focus mainly on the physical mechanism and the involved hydrodynamics of some lab and industrial applications. Finally, a short discussion on the role play by the convective mechanisms is given in order to provide integration of the exposed ideas.",book:{id:"6702",slug:"polymer-rheology",title:"Polymer Rheology",fullTitle:"Polymer Rheology"},signatures:"Ildebrando Pérez-Reyes, René Osvaldo Vargas-Aguilar, Samuel\nBernardo Pérez-Vega and Alejandro Sebastián Ortiz-Pérez",authors:[{id:"183938",title:"Dr.",name:"Samuel",middleName:null,surname:"Perez-Vega",slug:"samuel-perez-vega",fullName:"Samuel Perez-Vega"},{id:"186659",title:"Prof.",name:"Ildebrando",middleName:null,surname:"Pérez-Reyes",slug:"ildebrando-perez-reyes",fullName:"Ildebrando Pérez-Reyes"},{id:"242858",title:"Prof.",name:"Rene Osvaldo",middleName:null,surname:"Vargas-Aguilar",slug:"rene-osvaldo-vargas-aguilar",fullName:"Rene Osvaldo Vargas-Aguilar"},{id:"242859",title:"Prof.",name:"Alejandro Sebastian",middleName:null,surname:"Ortiz-Perez",slug:"alejandro-sebastian-ortiz-perez",fullName:"Alejandro Sebastian Ortiz-Perez"}]},{id:"30975",title:"Solution Properties of κ-Carrageenan and Its Interaction with Other Polysaccharides in Aqueous Media",slug:"solution-properties-of-k-carrageenan-and-its-interaction-with-other-polysaccharides-in-aqueous-media",totalDownloads:7672,totalCrossrefCites:5,totalDimensionsCites:33,abstract:null,book:{id:"1601",slug:"rheology",title:"Rheology",fullTitle:"Rheology"},signatures:"Alberto Tecante and María del Carmen Núñez Santiago",authors:[{id:"109087",title:"Prof.",name:"Alberto",middleName:null,surname:"Tecante",slug:"alberto-tecante",fullName:"Alberto Tecante"},{id:"109098",title:"Dr.",name:"Maria Del Carmen",middleName:null,surname:"Nunez-Santiago",slug:"maria-del-carmen-nunez-santiago",fullName:"Maria Del Carmen Nunez-Santiago"}]},{id:"30968",title:"Polymer Gel Rheology and Adhesion",slug:"rheology-and-adhesion-of-polymer-gels",totalDownloads:15940,totalCrossrefCites:12,totalDimensionsCites:75,abstract:null,book:{id:"1601",slug:"rheology",title:"Rheology",fullTitle:"Rheology"},signatures:"Anne M. Grillet, Nicholas B. Wyatt and Lindsey M. Gloe",authors:[{id:"110676",title:"Dr.",name:"Anne",middleName:null,surname:"Grillet",slug:"anne-grillet",fullName:"Anne Grillet"},{id:"138225",title:"Dr.",name:"Nicholas",middleName:null,surname:"Wyatt",slug:"nicholas-wyatt",fullName:"Nicholas Wyatt"},{id:"138226",title:"Ms.",name:"Lindsey",middleName:null,surname:"Gloe",slug:"lindsey-gloe",fullName:"Lindsey Gloe"}]},{id:"61430",title:"Effect of Maltodextrin Reduction and Native Agave Fructans Addition on the Rheological Behavior of Spray-Dried Juices",slug:"effect-of-maltodextrin-reduction-and-native-agave-fructans-addition-on-the-rheological-behavior-of-s",totalDownloads:1090,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Agave fructans have thermal protective and encapsulating properties as well as technological functions as stabilizers. The effect of the combination of maltodextrin 10% [w/v] and native agave fructans in concentrations of 0, 2, and 4% [w/v] on the rheological properties and microstructure, of spray-dried chayote, carrot, mango and pineapple powders was evaluated. The flow behavior was analyzed in a simple shear flow and low-cutting speed in the range of 5–200 s−1. The experimental data of fresh or reconstituted juices were fitted to different flow models such as Newtonian, Bingham, and Ostwald-de-Waele. The flow behavior of all juices can be described by the Bingham model with low plastic viscosities; the addition of fructans and the step of spray drying had no significant influence on the plastic viscosity of juices as compared to fresh juices.",book:{id:"6702",slug:"polymer-rheology",title:"Polymer Rheology",fullTitle:"Polymer Rheology"},signatures:"Darvin Ervey Jimenez-Sánchez, Montserrat Calderón-Santoyo,\nLaetitia Picart-Palmade, Pedro Ulises Bautista Rosales, Julio Cesar\nBarros-Castillo and Juan Arturo Ragazzo-Sánchez",authors:[{id:"234138",title:"Dr.",name:"Juan",middleName:null,surname:"Ragazzo-Sanchez",slug:"juan-ragazzo-sanchez",fullName:"Juan Ragazzo-Sanchez"},{id:"234139",title:"Dr.",name:"Darvin Ervey",middleName:null,surname:"Jimenez-Sánchez",slug:"darvin-ervey-jimenez-sanchez",fullName:"Darvin Ervey Jimenez-Sánchez"},{id:"234140",title:"Prof.",name:"Montserrat",middleName:null,surname:"Calderón-Santoyo",slug:"montserrat-calderon-santoyo",fullName:"Montserrat Calderón-Santoyo"},{id:"234143",title:"Prof.",name:"Laetitia",middleName:null,surname:"Picart-Palmade",slug:"laetitia-picart-palmade",fullName:"Laetitia Picart-Palmade"},{id:"234144",title:"MSc.",name:"Julio",middleName:null,surname:"Barros-Castillo",slug:"julio-barros-castillo",fullName:"Julio Barros-Castillo"},{id:"257866",title:"Dr.",name:"Pedro Ulises",middleName:null,surname:"Bautista-Rosales",slug:"pedro-ulises-bautista-rosales",fullName:"Pedro Ulises Bautista-Rosales"}]},{id:"60958",title:"Magnetorheology of Polymer Systems",slug:"magnetorheology-of-polymer-systems",totalDownloads:1004,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"The results of researches of a magnetic field effect on rheological properties of both paramagnetic, and diamagnetic polymer systems are described. Influence of intensity and the direction of power lines of the magnetic field on the viscosity of magnetic liquids and magnetorheological suspensions is analyzed. Results of theoretical researches of the magnetic field effect on the diamagnetic macromolecule orientation in solutions are discussed. The data on the influence of the magnetic field on rheological parameters of cellulose ether solutions are generalized and analyzed. The rheological parameters are compared with a change of studied system structure under magnetic field. The concentration dependences of viscosity and the sizes of supramolecular particles in solutions are compared. The rheological behavior of systems in a region of phase transitions is considered. Concentration dependences of the viscosity are described by curves with a maximum which concentration corresponds to a phase transition concentration.",book:{id:"6702",slug:"polymer-rheology",title:"Polymer Rheology",fullTitle:"Polymer Rheology"},signatures:"Sergey Vshivkov and Elena Rusinova",authors:[{id:"233365",title:"Prof.",name:"Sergey",middleName:"Anatol\\'Evich",surname:"Vshivkov",slug:"sergey-vshivkov",fullName:"Sergey Vshivkov"}]}],onlineFirstChaptersFilter:{topicId:"962",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,annualVolume:11975,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo, Ph.D., is a professor in the Department of Engineering, University of Naples “Parthenope,” Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino and Southern Lazio, Italy. Her research interests include multi-criteria decision analysis, industrial plants, logistics, manufacturing, and safety. She serves as an associate editor for the International Journal of the Analytic Hierarchy Process and is an editorial board member for several other journals. She is also a member of the Analytic Hierarchy Process (AHP) Academy.",institutionString:"Parthenope University of Naples",institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,annualVolume:11976,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,annualVolume:11977,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,annualVolume:11978,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. Current research interests include trophic flows across ecosystems; watershed impacts of land-use change on biodiversity and ecosystem functioning; ecological civilization and water resource management; urban ecology and urban/rural sustainable development.",institutionString:null,institution:{name:"Soochow University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"95",title:"Urban Planning and Environmental Management",coverUrl:"https://cdn.intechopen.com/series_topics/covers/95.jpg",isOpenForSubmission:!0,annualVolume:11979,editor:{id:"181079",title:"Dr.",name:"Christoph",middleName:null,surname:"Lüthi",slug:"christoph-luthi",fullName:"Christoph Lüthi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRHSqQAO/Profile_Picture_2022-04-12T15:51:33.png",biography:"Dr. Christoph Lüthi is an urban infrastructure planner with over 25 years of experience in planning and design of urban infrastructure in middle and low-income countries. He holds a Master’s Degree in Urban Development Planning from the University College of London (UCL), and a Ph.D. in Urban Planning & Engineering from TU Berlin. He has conducted applied research on urban planning and infrastructure issues in over 20 countries in Africa and Asia. In 2005 he joined Eawag-Sandec as Leader of the Strategic Environmental Sanitation Planning Group. 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He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. 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