RIVELILSON MENDES DE FREITAS

By Paulo Michel Pinheiro Ferreira, Éverton José Ferreira de Araújo, Jurandy do Nascimento Silva, Rivelilson Mendes de Freitas, Nagilla Daniela de Jesus Costa, Samara Ferreira de Carvalho Oliveira, Janiella Buenos Aires Pereira, Jaksilania Aires Forte Pinheiro, Maria Carolina de Abreu and Cláudia Pessoa

Part of the book: Pharmacology and Therapeutics

By Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas, Valéria Lima Silva, Lidiane da Silva Araújo, Cassio Herbert Santos de Melo and Felipe Pereira Da Silva Santos

The antioxidant and anti-inflammatory properties of Citrus flavonoids can play a key role in their activity against several degenerative diseases and particularly brain diseases. In Brazil promising studies deposited in the patents “pharmaceutical formulation” form was obtained from the inclusion of Citrus sinensis L. (orange) essential oil with β-cyclodextrin and Citrus limon (lemon) compounds and their applications in therapy of Alzheimer’s disease. In this chapter, we report activities of active compounds present in the genus Citrus, which include antioxidant, anti-inflammatory, anxiolytic, insecticidal, and anticholinesterase activities. These activities are associated with some neurodegenerative diseases such as Alzheimer’s disease (AD). Pharmaceutical formulations containing such compounds (for example, inhibitors such as acetylcholinesterase (AChE) of C. limon (5,8-dimethoxy-psoralen and 5,7-dimethoxycumarin) and essential oil from C. sinensis oils are reported in this chapter. These results indicate that the effects of the essential oil and substances of Citrus species are very interesting for further isolation of AChE inhibitors that can be used in the formulation of natural products for neurodegenerative diseases.

Part of the book: Citrus Pathology