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",isbn:"978-1-83969-347-2",printIsbn:"978-1-83969-346-5",pdfIsbn:"978-1-83969-348-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"4fc73beb0e4416a20cc70c8163fe436f",bookSignature:"Dr. Pinar Erkekoglu",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/9836.jpg",keywords:"KRAS Gene, Oncogene, Tumor Suppressor Gene, Mutation, Cancer, Microtubule-Associated Protein (MAP), GTPase, Pathological Conditions, Epidermal Nevus, Noonan Syndrome, Costello Syndrome, Environmental Chemicals",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 17th 2020",dateEndSecondStepPublish:"December 15th 2020",dateEndThirdStepPublish:"February 13th 2021",dateEndFourthStepPublish:"May 4th 2021",dateEndFifthStepPublish:"July 3rd 2021",remainingDaysToSecondStep:"2 months",secondStepPassed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"A pioneering researcher in toxicology, vaccinology, cosmetics, and Board Member of Turkish Pharmacists Association Pharmacy Academia and Board Member of Hacettepe Vaccine Institute. Published more than 150 scientific papers in international/national journals. Associate editor of the Turkish Journal of Pharmaceutical Sciences.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"109978",title:"Prof.",name:"Pınar",middleName:null,surname:"Erkekoglu",slug:"pinar-erkekoglu",fullName:"Pınar Erkekoglu",profilePictureURL:"https://mts.intechopen.com/storage/users/109978/images/system/109978.JPG",biography:"Pınar Erkekoglu was born in Ankara, Turkey. She graduated with a BS from Hacettepe University Faculty of Pharmacy. Later, she received an MSci and Ph.D. in Toxicology. She completed a part of her Ph.D. studies in Grenoble, France, at Universite Joseph Fourier and CEA/INAC/LAN after receiving a full scholarship from both the Erasmus Scholarship Program and CEA. She worked as a post-doc and a visiting associate in the Biological Engineering Department at Massachusetts Institute of Technology. She is currently working as a full professor at Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology. Her main study interests are clinical and medical aspects of toxicology, endocrine-disrupting chemicals, and oxidative stress. She has published more than 150 papers in national and international journals. 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From chapter submission and review to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"38839",title:"Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma",doi:"10.5772/51482",slug:"porphyrin-synthesis-from-5-aminolevulinic-acid-in-patients-with-glioma",body:'\n\t\tThe molecule 5-aminolevulinic acid (5-ALA) is a substrate for a heme synthesized in cells using succinyl CoA and glycine. Initially, 5-ALA is converted to porphobilinogen (PBG), and the metabolism progresses by the action of PBG deaminase, and its product is incorporated into the mitochondria via uroporphyrinogen and coproporphyrinogen by an enzymatic reaction and transformed into protoporphyrin IX (PPIX). This PPIX is then converted to a heme by the action of ferrochelatase. These metabolic reactions are conducted in the liver and erythroblasts of normal human subjects [16]. It is thought that a larger amount of 5-ALA is incorporated by rapidly proliferating tumor cells as compared to normal cells, due to the active synthesis of heme [5, 20]. In the metabolic pathway of 5-ALA, it is reported that the rate limiting enzyme in normal cells is different from that in tumor cells [16]. PBG deaminase is the rate limiting enzyme in normal cells [3]. Large amounts of uroporphyrinogen, coproporphyrinogen, and PPIX are produced in tumor cells compared to normal cells because metabolism after the PBG is promoted by high PBG deaminase activity and low ferrochelatase activity [15]. The PPIX accumulates in tumor cells and produces a red fluorescent response to ultraviolet light. Intraoperative photodynamic diagnosis using this method is used for patients with glioma [21, 24, 26]. There are numerous reports concerning the PPIX concentration in the tumor tissue; however, reports concerning plasma titers and urinary excretion of uroporphyrinogen and coproporphyrinogen after 5-ALA administration are rare [25]. In this study, 5-ALA was administered to healthy adult volunteers, and changes in serum and urinary porphyrins were measured. Urinary excretion of porphyrins in volunteers and patients with brain tumors after the 5-ALA administration were compared and examined.
\n\t\tHealthy adult volunteers (n = 8) and 58 patients with glioma (12 benign gliomas (WHO grade II) and 46 glioblastomas) who were resected by intraoperative fluorescence diagnosis using 5-ALA were enrolled in the study. Eight adult volunteers were given 1 gram of 5-ALA orally, and blood sampling was done before administration, 2 hours, 4 hours, and 6 hours later. Blood samples were analyzed for plasma titers of 5-ALA, PPIX, coproporphyrin I (CPI), coproporphyrin III (CPIII), uroporphyrin I (UPI), and uroporphyrin III (UPIII). Urine collection was done before and 4 hours after 5-ALA administration, and the urinary excretion of 5-ALA, CPI, CPIII, UPI, and UPIII were measured. Fifty-eight patients with glioma were given 1 gram of 5-ALA orally 2 hours before anesthesia, and blood and urine samples were collected from these patients 4 hours later for analyses of plasma titers and urinary excretion of 5-ALA, PPIX, CPI, CPIII, UPI, and UPIII. Intraoperative fluorescence diagnosis for 58 patients with glioma was performed using a semiconductor laser device (VLD-V1 version 2: M & M Co., Ltd., Tokyo, Japan). The brain tumor was exposed to a laser light that had a peak wavelength of 405 nm and a light output of 120 mW by placing the optical fiber as close as possible. The spectra of the response light from tumors were analyzed by a personal computer for a fluorescent identification of PPIX and the measurement of the fluorescent objective strength. When fluorescence from PPIX was observed, a waveform with a peak at 636 nm was observed. When the intensity of the peak at 636 nm was ≥3000, the tumor was defined as a strong fluorescence tumor. In contrast, when the intensity of the peak at 636 nm was < 3000, the tumor was defined as a weak fluorescence tumor. Two groups distributed based on these spectra were examined for macroscopic findings; i.e., fluorescence for the strong PPIX group was observed macroscopically in all of the strong fluorescence tumors. When there was not a waveform peak at 636 nm, and the fluorescence of PPIX was not observed for a tumor, the tumor was considered to be a non-fluorescence tumor. The total urinary excretion products were adjusted for creatinine value. Testing for significant differences was done using analysis of variance (analysis of variance; ANOVA) or the PLSD (protected least significant difference) method of Fisher as a post-hoc test.
\n\t\t\t\n\t\tThe plasma 5-ALA concentration in volunteers reached a peak 2 hours after 5-ALA administration (Figure 1). The plasma titer peaks of protoporphyrin IX, CPI, and CPIII in volunteers were reached 2 hours after administration of 5-ALA. The plasma titer peaks of UPI and UPIII in volunteers were reached 4 hours after 5-ALA administration (Figure 2). The plasma titer and urinary excretion of CPI, CPIII, UPI, UPIII, and 5-ALA were not significantly different in volunteers and glioma patients prior to 5-ALA administration (data not shown). Urinary excretion CPI and CPIII 4 hours after 5-ALA administration were significantly higher in patients with glioma than in volunteers (Figures 3, 4) (p <0.0001). Urinary excretion of UPI and UPIII 4 hours after 5-ALA administration in volunteers and glioma patients were not significantly different (Figures 5,6). Urinary excretion of CPI, CPIII, UPI, UPIII, and 5-ALA 4 hours after 5-ALA administration in patients with benign glioma was not significantly different compared to patients with glioblastoma. All of the glioblastomas were strong fluorescence tumors. Benign gliomas were comprised of 3 strong fluorescence tumors, 5 weak fluorescence tumors, and 4 non-fluorescence tumors. Urinary excretion of CPI, CPIII, UPI, UPIII, and 5-ALA 4 hours after 5-ALA administration was not significantly different when comparing strong fluorescence tumors, weak fluorescence tumors, and non-fluorescence tumors in benign glioma patients (data not shown).
\n\t\t\tGraph shows the plasma titer of 5-ALA when 5-ALA was administered to volunteers. The peak concentration is reached 2 hours after administration of 5-ALA, and the concentration is ≤ 50% of the peak level 4 hours later. The concentration is ≤ 10% of the peak level 6 hours later.
Graph shows various plasma titers of porphyrins when 5-ALA was administered to volunteers. The plasma titers of protoporphyrin IX, CPI, and CPIII reached maximal levels 2 hours following 5-ALA administration. The plasma titers of UPI and UPIII peaked at 4 hours after administration of 5-ALA.
Graph shows urinary excretion of CPI 4 hours following administration of 5-ALA to normal volunteers, and patients with benign gliomas and glioblastomas. Urinary excretion of CPI in patients with benign gliomas and glioblastomas was significantly higher than in normal volunteers.
Graph shows urinary excretion of CPIII 4 hours after 5-ALA was administered to normal volunteers, and patients with benign gliomas and glioblastomas. Urinary excretion of CPIII in patients with benign gliomas and glioblastomas was significantly higher than in normal volunteers.
It was reported that plasma titers and urinary excretion of porphyrins were increased when tumor-bearing mice were administered 5-ALA [8]. Also, it was reported that the plasma titers and urinary excretion of these porphyrins were increased when 5-ALA was administered to adult mice without malignant tumors [14]. The reason why these porphyrins increase in healthy volunteers after 5-ALA administration might be that those porphyrins leak as the intermediate product after being metabolized by the erythroblasts and liver [14]. When healthy volunteers were administered 5-ALA in our study, the plasma titers of 5-ALA, CPI, CPIII, UPI, UPIII, and PPIX reached maximum levels at 2-4 hours following 5-ALA administration. Therefore, it was thought that most of these porphyrins were done being excreted in the urine 4 hours after 5-ALA administration.
\n\t\t\tGraph shows urinary excretion of UPI 4 hours after 5-ALA was administered to normal volunteers, and patients with benign gliomas and glioblastomas. The urinary excretion of UPI showed no significant differences among subjects who were normal volunteers, and patients with benign gliomas and glioblastomas.
Graph shows urinary excretion of UPIII 4 hours after 5-ALA was administered to normal volunteers and patients with benign gliomas and the glioblastomas. The urinary excretion of UPIII showed no significant differences among subjects who were normal volunteers, and patients with benign gliomas and glioblastomas
If 5-ALA were not administered, there would be no difference in the metabolism of these porphyrins in volunteers and glioma patients, because plasma titers and urinary excretion of CPI, CPIII, UPI, UPIII, and 5-ALA were not significantly different in volunteers and glioma patients prior to 5-ALA administration. Also, there would not be the specific metabolic process in tumor cells for converting 5-ALA to uroporphyrin, because urinary excretion of UPI and UPIII was not different when comparing volunteers, patients with benign glioma, and patients with glioblastoma. However, the urinary excretion of CPI and CPIII 4 hours after 5-ALA administration significantly increased in patients with glioma as compared to volunteers. Therefore, it was thought that high levels of CPI and CPIII were being produced in tumor cells as compared to normal cells. Heme is rapidly synthesized in cells with accelerated metabolism, such as tumor cells, and 5-ALA is incorporated into tumor cells and metabolized. Consequently, large quantities of CPI and CPIII are produced as the metabolites, and it was thought that urinary excretion increased [11]. In the healthy adults without a tumor, PBG deaminase becomes the rate limiting enzyme even if 5-ALA is incorporated into cells, and extensive metabolism occurs prior to production of PBG. Therefore, CPI and CPIII, which are down-stream metabolites, will not be produced in large quantities [3].
\n\t\t\t\n\t\t\tIt is known that ATP-binding cassette (ABC) transporters, such as ABCG2 and ABCB6, are associated with trafficking of these porphyrins. ABCG2 is expressed mainly in the cell membrane and serves as the active transporter for anticancer drugs present outside of cells [6]. ABCG2 drains excessive levels of porphyrin outside of cells while performing this function [13]. ABCB6 transports coproporphyrinogen from the cytoplasm into the mitochondria, and both. ABCG2 and ABCB6 are overexpressed in cancer cells [6, 12, 23]. ABCG2 is overexpressed in brain tumors [1, 9], and its presence is more common in malignant tumors [9]. CPI and CPIII that are produced in the cytoplasm of tumor cells are actively transported by ABCG2 overexpressed in brain tumor cells. This was considered the cause of higher urinary excretion of CPI and CPIII in patients with a brain tumor compared to normal volunteers. Similarly, it is reported that urinary excretion of porphyrins increases even in cancers other than brain tumors [7]. Therefore, these porphyrins may be used as a nonspecific marker in screening for tumors [25]. In other words, presence of hypermetabolic tumor cells may be suggested if urinary excretion measures of CPI and CPIII are elevated in a person orally administered orally 5-ALA. In such a case, it may be useful to investigate the whole body for the presence of a tumor.
\n\t\t\tThe urinary excretion of CPI and CPIII were not different in benign glioma and glioblastoma patients, and the metabolism of 5-ALA to produce CPI and CPIII should not differ between benign gliomas and glioblastomas. Many of the benign gliomas were weak fluorescence or non-fluorescence tumors, whereas all glioblastomas were strong fluorescence tumors. In other words, high levels of PPIX had accumulated in the glioblastomas, while only low levels of PPIX accumulated in benign gliomas. Metabolic processes involved in the pathway leading from CPI and CP III to PPIX will be different in benign gliomas and glioblastomas. These differences will be due differences in the activity of ABCB6 which transports CPI and CPIII in mitochondria, or coproporphyrinogen oxidase, which converts CPI and CPIII into PPIX. Concerning these ABC transporters, it is reported in accordance with genetic polymorphism that the functions and levels of expression are different [23]. Therefore, the intracellular PPIX concentration will be higher for a tumor having higher levels of ABCB6 [12]. Also, the glioblastomas will have much higher levels of PPIX than benign gliomas, because the presence of coproporphyrinogen oxidase is common in a malignant tumor [22].
\n\t\t\tHowever, differences in PPIX accumulation (fluorescent strength) are not necessarily proportional to urinary excretion of these porphyrins after 5-ALA administration. The volume of a tumor (the total amount of PPIX) is one factor affecting results. The factors related to differences in accumulation of protoporphyrin IX have been investigated in various ways, and various factors such as ALA uptake by cells [2, 19], mitochondrial properties [18], molecules involved in PpIX metabolism including porphobilinogen deaminase [4], ferrochelatase [15], iron content [10], transferring receptor [17], and mRNA levels of the coproporphyrinogen oxidase (CPOX) gene [13] are thought to be associated with protoporphyrin IX accumulation. Due to the involvement of these multiple factors, differences in the accumulation of PPIX will occur [24].
\n\t\tFollowing administration of 5-ALA, patients with a brain tumor showed higher urinary excretion of CPI and CPIII than did healthy volunteers. This was due to the active production of porphyrins in metabolically active tumor cells. The urinary excretion of CPI and CPIII following administration of 5-ALAcould possibly be used as a screening assay for the presence or absence of a tumor. Differences in the presence of the ABC transporter may contribute to metabolic differences of the porphyrins in benign gliomas and glioblastomas.
\n\t\tThe study of physical hydraulic models plays a role which is vital in the planning and designing of almost all hydraulic and hydrologic structures. May it be the stilling basins, spillways of barrages, river training works, hydraulic siphons, or even simple bridges, they are generally designed, evaluated, refined, and improved on the basis of physical hydraulic model studies. Physical model studies are comparatively expensive, costly, consume lots of time and resources to build and operate, and require technical labor and expertise in developing and testing the model. The selection of appropriate scale ratios between prototype and model plays a very significant and imperative role for the reliability and rationality of the results obtained.
\nResearchers and engineers working in the field, face a real challenge once they have to finalize on the basis of physical and/or numerical models, the rehabilitation and modernization works for any already constructed and operational hydraulic structure. The success of any rehabilitation work depends upon the precise and accurate identification of hydraulic and hydrologic problems on the prototype structure, because any failure may lead to partial or complete wastage of huge investments.
\nThe laws of similitude enable a researcher to predict the likely performance of prototype hydraulic structures from tests made with far less expensive models. We need not use the same fluid for the model as the prototype. We may obtain valuable results at a minimum cost from the tests conducted on the small scale hydraulic models. Any textbook on hydraulic physical modeling will tell us that the following similarities have to be ensured between the model and the prototype hydraulic structure [1, 2].
\nModel and prototype should have identical shapes but differ only in size as per the defined scale ratio. This would ensure geometrically similar flows. Under certain conditions, distorted models are resorted to by having different scale ratios for the lateral, longitudinal, and vertical directions, but then the same has to be incorporated during the interpretation of results.
\nRatios of the velocities on all corresponding points on the model and prototype hydraulic structure should be the same to ensure the same kinematics of flow.
\nThe quantum and direction of all forces acting on the corresponding points on the model and prototype should be in the same ratio, to ensure the same dynamics of the flow. Dynamic similarity can also be ensured by ensuring similarity of the combination of forces, by following the Froude Law, Reynolds Law, Mach Law, etc., for modeling.
\nPhysical modeling of hydraulic structures has been in use since the times of Leonardo Da Vinci. However, since then this art and science have gone manifold changes, developments, and positive improvements. Such models provide a visual insight into the hydraulic phenomena of water and fluid flows. These models also provide technical flow data through the elaborate system of instrumentation provided. The data and flow visuals can be recorded for future reference, computations, training materials, and records.
\nThe role of hydrological modeling has been well described in [3], wherein the authors reiterate that hydrological models are in fact basic, theoretical, and physical representations of the hydrologic cycle, and these are often used for the understanding and prediction of hydrological processes. They categorize the hydrological models as (a) models which are based on data collection, and (b) black-box models which are based on process description.
\nBecause of the importance and special role of physical hydraulic modeling, various renowned organizations have developed their physical hydraulic research centers. The most common and well-known are the Waterways Experiment Station (WES) of the US Army Corps of Engineers and Hydraulic Research Station (HRS) of Punjab Irrigation Department, Pakistan.
\nThe US Army Corps of Engineers Waterways Experiment Station (WES) was created in 1929 to provide support for the vast flood control plan for the entire lower Mississippi valley after the tragedy of the 1927 most horrific river flood. The WES laboratory complex located at Vicksburg, Mississippi is now the principle research, testing, and development facility, which supports studies in many other fields in addition to its primary field of hydraulic engineering. WES provides services for training, and technical assistance, research, and also software development, which reflects the state-of-the-art expertise of WES in hydrologic engineering and closely associated fields of planning analysis. In its research and development work, WES uses more application of model experiments employing the principles of hydraulics. WES has made a significant contribution through the publication and distribution of its research reports.
\nHydraulic Research Station, located at Nandipur near Gujranwala, in Pakistan is one of the largest research laboratories in the world. This field research station was established in 1926 and is under the administrative control of the Irrigation Research Institute, Lahore being its field station. The Nandipur station has 40 hectares of land divided into 22 research bays commonly called as research trays. Through a small irrigation channel, the water availability of 15 cumecs and a gravity head of 4 meters is provided, however for higher heads pumping facility is also available. The Nandipur Hydraulic Research Station meets the requirement of the study of numerous problems that are related to planning, operation, and management of water resources. Physical models for almost all the major irrigation and hydraulic structures now present in the country have been run, tested, and optimized at this station.
\nHydraulic Research Station at Nandipur has carried out model studies of almost all major hydraulic engineering projects undertaken in Pakistan and India in the pre-partition as well as the post-partition era. The major projects of Mangla Dam and Tarbela Dam which were constructed as part of the Indus Basin Treaty were also modeled in this facility. Many other barrages, weirs, link canals, and river training works have been modeled and approved prior to the finalization of their designs. A sample of the physical hydraulic modeling projects undertaken by the Hydraulic Research Station is displayed in Figures 1 and 2.
\nFlow from Flip Bucket Energy Dissipater.
Model of a Typical Barrage.
In the recent past, the rationality of the massive hydraulic structure of Jinnah Barrage [4, 5] was questioned as a model study indicated that at existing conditions of water levels the formed hydraulic jump was located on the glacis only up to a discharge of 400,000 cusecs. The hydraulic performance of the barrage, under-sluices, silt excluders, and also the subsidiary weir was yet not tested at higher discharges. Mahboob [6, 7] reviewed the design of Kalabagh Barrage and he found it acceptable only after the physical hydraulic model study because the hydraulic modeling study for energy dissipation under the conditions of existing water levels pointed out that hydraulic jump over the horizontal floor was repelled by the excessive lowering of the channel bed at the downstream (retrogression) (Figure 3).
\nModel Study of Taunsa Hydro Power Project.
The hydraulic modeling study cited here targets to examine sedimentation aspects of two cascade reservoirs on Poonch River; with the help of physical modeling and numerical simulation. A physical model of Poonch River was prepared at Nandipur Research Institute to study the sediment transport behavior [8]. After the base test, the model was used to get data for various scenarios of sediment flushing in the cascade reservoir system. The River geometry, riverbanks, hydraulic structures, cross-sections, and other physical attributes of the river were prepared from a topographic survey using AutoCAD. These files were used in HEC-RAS and BASEMENT for simulations (Figure 4).
\nModel Study of Poonch River Sedimentation Project.
Delta profile and flushing were modeled by HEC-RAS 5.0. The simulation showed that the life of the un-sluiced Gulpur HPP is about 14–15 years and that of Rajdhani is about 35 years. To enhance the life of the project, annually 4–5 days are required for flushing with an optimized discharge of about 250 m3/s. Model verification was performed by calculating the bed topography and flushing efficiency. The results obtained through the model were consistent with bed changes, demonstrating its suitability for the regeneration of regression channels and lateral erosion (Figure 5).
\nModel Study of Poonch River Sedimentation Project.
Other techniques in addition to physical hydraulic modeling available to a researcher are mathematical modeling, statistical modeling, and numerical modeling. With the advent of modern computers having speedy and fast processors, massive data storage, better data management software, and intelligent computational techniques the statistical modeling and numerical modeling have become the favorites of every researcher and engineer. The cutting edge graphics cards and attractive presentation techniques have also added to the magnetism of such indoor modeling. However, despite all this, the value and importance of physical hydraulic modeling cannot be overshadowed by these. The natural intricacies, physical behavior, the kinematics and dynamics of all fluids and especially large mass flows of water can only be studied through physical modeling.
\nWith the innovation of new materials of construction including the nano-materials, the physical hydraulic modeling has been revived. Now very intricate designs can be created and manufactured using new and modern materials. The same is true for hybrid and very strong epoxies and sealing materials which now help in making watertight models. Fabrication of models and their miniature parts has also been revolutionized by laser cutting, computerized numerical machines that can make precision model parts.
\nRevolution in measuring instruments for all hydraulic parameters has also provided a quantum jump to physical hydraulic modeling. Doppler velocimetry, very sensitive and accurate probes and pressure transducers, laser leveling gauges, and other such instrumentation can now be used to obtain and collect very sophisticated data for physical hydraulic models.
\nThe latest techniques in flow visualization have done wonders in fluid mechanics and hydraulic modeling. Modern electronics and advancement in graphics, optics, and sensors has revitalized the hydraulic modeling and made it an advanced and modern field of science and technology.
\nOn the other hand, the models based on process description also called deterministic models are rather complicated as compared to the stochastic hydrological models representing surface runoff, channel flow, subsurface flow, and evapotranspiration. Such models cannot by physically modeled, and therefore these have to be computer modeled [3].
\nThe art, science, and technique of planning, construction, and operation of physical hydraulic modeling are losing the race against numerical and computer modeling. However, there is a dire need that due to its very special place in research and investigation, this modeling technique should remain in vogue. For this very purpose its education, teaching, and engineering practice may be included in the curricula of various universities, colleges, and other technical training institutes.
\nFor very important and significant hydraulic structures, the failure of which cannot be afforded due to various reasons, it may be made mandatory that physical hydraulic modeling is carried out prior to the finalization of designs of construction and rehabilitation.
\nIntechOpen aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. We uphold a flexible Copyright Policy, guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Monograph",metaDescription:"IntechOpen aims to guarantee that original material is published while at the same time giving significant freedom to our authors. For that matter, we uphold a flexible copyright policy meaning that there is no transfer of copyright to the publisher and authors retain exclusive copyright to their work.",metaKeywords:null,canonicalURL:"/page/publication-agreement-monograph",contentRaw:'[{"type":"htmlEditorComponent","content":"When submitting a manuscript, the Author is required to accept the Terms and Conditions set out in our Publication Agreement – Monographs/Compacts as follows:
\\n\\nCORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\nSubject to the following Article, the Author grants to IntechOpen, during the full term of copyright, and any extensions or renewals of that term, the following:
\\n\\nThe foregoing licenses shall survive the expiry or termination of this Publication Agreement for any reason.
\\n\\nThe Author, on his or her own behalf and on behalf of any of the Co-Authors, reserves the following rights in the Work but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Work as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\\n\\nThe Author, and any Co-Author, confirms that they are, and will remain, a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Work and all versions of it created during IntechOpen's editing process, including all published versions, is retained by the Author and any Co-Authors.
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\\n\\nAll rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the specific approval of the Author or Co-Authors.
\\n\\nThe Author, on his/her own behalf and on behalf of the Co-Authors, will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Work as a consequence of IntechOpen's changes to the Work arising from the translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits as determined by IntechOpen.
\\n\\nAUTHOR'S DUTIES
\\n\\nWhen distributing or re-publishing the Work, the Author agrees to credit the Monograph/Compacts as the source of first publication, as well as IntechOpen. The Author guarantees that Co-Authors will also credit the Monograph/Compacts as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Work.
\\n\\nThe Author agrees to:
\\n\\nThe Author will be held responsible for the payment of the agreed Open Access Publishing Fee before the completion of the project (Monograph/Compacts publication).
\\n\\nAll payments shall be due 30 days from the date of issue of the invoice. The Author or whoever is paying on behalf of the Author and Co-Authors will bear all banking and similar charges incurred.
\\n\\nThe Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Work worldwide for the full term of the above licenses, and shall provide to IntechOpen, at its request, the original copies of such consents for inspection or the photocopies of such consents.
\\n\\nThe Author shall obtain written informed consent for publication from those who might recognize themselves or be identified by others, for example from case reports or photographs.
\\n\\nThe Author shall respect confidentiality during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Author and Co-Authors are confidential and are intended only for the recipients. The contents of any communication may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
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\\n\\nThe Author and Co-Authors confirm and warrant that the Work does not and will not breach any applicable law or the rights of any third party and, specifically, that the Work contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy.
\\n\\nThe Author and Co-Authors confirm that: (i) the Work is their original work and is not copied wholly or substantially from any other work or material or any other source; (ii) the Work has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) Authors and any applicable Co-Authors are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) Authors and any applicable Co-Authors have not assigned, and will not during the term of this Publication Agreement purport to assign, any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\\n\\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\\n\\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\nTERMINATION
\\n\\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\\n\\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\\n\\nIntechOpen’s DUTIES AND RIGHTS
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\\n\\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\\n\\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\nMISCELLANEOUS
\\n\\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\\n\\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\\n\\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\\n\\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\\n\\nPolicy last updated: 2018-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'When submitting a manuscript, the Author is required to accept the Terms and Conditions set out in our Publication Agreement – Monographs/Compacts as follows:
\n\nCORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\nSubject to the following Article, the Author grants to IntechOpen, during the full term of copyright, and any extensions or renewals of that term, the following:
\n\nThe foregoing licenses shall survive the expiry or termination of this Publication Agreement for any reason.
\n\nThe Author, on his or her own behalf and on behalf of any of the Co-Authors, reserves the following rights in the Work but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Work as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Author, and any Co-Author, confirms that they are, and will remain, a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Work and all versions of it created during IntechOpen's editing process, including all published versions, is retained by the Author and any Co-Authors.
\n\nSubject to the license granted above, the Author and Co-Authors retain patent, trademark and other intellectual property rights to the Work.
\n\nAll rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the specific approval of the Author or Co-Authors.
\n\nThe Author, on his/her own behalf and on behalf of the Co-Authors, will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Work as a consequence of IntechOpen's changes to the Work arising from the translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits as determined by IntechOpen.
\n\nAUTHOR'S DUTIES
\n\nWhen distributing or re-publishing the Work, the Author agrees to credit the Monograph/Compacts as the source of first publication, as well as IntechOpen. The Author guarantees that Co-Authors will also credit the Monograph/Compacts as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Work.
\n\nThe Author agrees to:
\n\nThe Author will be held responsible for the payment of the agreed Open Access Publishing Fee before the completion of the project (Monograph/Compacts publication).
\n\nAll payments shall be due 30 days from the date of issue of the invoice. The Author or whoever is paying on behalf of the Author and Co-Authors will bear all banking and similar charges incurred.
\n\nThe Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Work worldwide for the full term of the above licenses, and shall provide to IntechOpen, at its request, the original copies of such consents for inspection or the photocopies of such consents.
\n\nThe Author shall obtain written informed consent for publication from those who might recognize themselves or be identified by others, for example from case reports or photographs.
\n\nThe Author shall respect confidentiality during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Author and Co-Authors are confidential and are intended only for the recipients. The contents of any communication may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\nAUTHOR'S WARRANTY
\n\nThe Author and Co-Authors confirm and warrant that the Work does not and will not breach any applicable law or the rights of any third party and, specifically, that the Work contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy.
\n\nThe Author and Co-Authors confirm that: (i) the Work is their original work and is not copied wholly or substantially from any other work or material or any other source; (ii) the Work has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) Authors and any applicable Co-Authors are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) Authors and any applicable Co-Authors have not assigned, and will not during the term of this Publication Agreement purport to assign, any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\n\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\n\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\nTERMINATION
\n\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\n\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\n\nIntechOpen’s DUTIES AND RIGHTS
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\n\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\n\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\n\nMISCELLANEOUS
\n\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\n\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\n\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\n\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\n\nPolicy last updated: 2018-09-11
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. 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