Khalid Hussain Bhat

Sher-e-Kashmir University of Agriculture Science and Technology

Dr Khalid Hussain Bhat did his masters in biochemistry with a distinction from the University of Kashmir, India for which he received a university gold medal. After qualifying for a national fellowship for a research program, he moved to the Centre for DNA Fingerprinting and Diagnostics, Hyderabad, a premier basic research institute in India. Here he pursued his PhD in molecular immunology under the mentorship of Dr Sangita Mukhopadhyay. After completion of dissertation, he joined Prof. Amy L. Kenter at University of Illinois at Chicago, USA to investigate the mechanism of antibody repertoire generation. Dr Bhat has recently started his own laboratory at Sher-eKashmir University of Agricultural Sciences and Technology at Kashmir in India. Besides teaching undergraduate and graduate students, his research interests have expanded to plant microbes.

1books edited

1chapters authored

Latest work with IntechOpen by Khalid Hussain Bhat

Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.

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Macrophage Activation

Edited by Khalid Hussain Bhat

Chapters authored

Mycobacterium tuberculosis: Macrophage Takeover and Modulation of Innate Effector Responses

By Khalid Hussain Bhat and Imtiyaz Yaseen

Macrophages mediate the first line of defense in the host against various intracellular pathogens. They are armed with several immune-effector mechanisms to detect and combat pathogens. However, intracellular pathogens have developed strategies to overcome the macrophage protective immune responses and colonize inside the macrophages. Tuberculosis (TB), both pulmonary and extrapulmonary, is an infectious disease of global concern caused by Mycobacterium tuberculosis. M. tuberculosis is a highly successful pathogen and has acquired various strategies to downregulate critical innate-effector immune responses of macrophages such as phagosome-lysosome fusion, antigen presentation, autophagy, and inhibition of reactive oxygen (ROI) and reactive nitrogen (RNI) species to ensure its longer survival inside the macrophages. In addition to these, the bacilli also modulate T cell immune response which can help the bacilli to survive inside the host for a long time. In this chapter, we focus to describe important macrophage innate defense mechanisms and the signaling that can influence T cell adaptive response and the strategies adopted by the bacilli to exploit these signaling cascades to favor its replication and persistence inside the macrophages for establishing a productive infection.

Part of the book: Mycobacterium

Khalid Hussain Bhat

Latest work with IntechOpen by Khalid Hussain Bhat

Macrophage Activation

Chapters authored

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