Heterologous expression of MTs in
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-signs-new-contract-with-cepiec-china-for-distribution-of-open-access-books-20210319",title:"IntechOpen Signs New Contract with CEPIEC, China for Distribution of Open Access Books"},{slug:"150-million-downloads-and-counting-20210316",title:"150 Million Downloads and Counting"},{slug:"intechopen-secures-indefinite-content-preservation-with-clockss-20210309",title:"IntechOpen Secures Indefinite Content Preservation with CLOCKSS"},{slug:"intechopen-expands-to-all-global-amazon-channels-with-full-catalog-of-books-20210308",title:"IntechOpen Expands to All Global Amazon Channels with Full Catalog of Books"},{slug:"stanford-university-identifies-top-2-scientists-over-1-000-are-intechopen-authors-and-editors-20210122",title:"Stanford University Identifies Top 2% Scientists, Over 1,000 are IntechOpen Authors and Editors"},{slug:"intechopen-authors-included-in-the-highly-cited-researchers-list-for-2020-20210121",title:"IntechOpen Authors Included in the Highly Cited Researchers List for 2020"},{slug:"intechopen-maintains-position-as-the-world-s-largest-oa-book-publisher-20201218",title:"IntechOpen Maintains Position as the World’s Largest OA Book Publisher"},{slug:"all-intechopen-books-available-on-perlego-20201215",title:"All IntechOpen Books Available on Perlego"}]},book:{item:{type:"book",id:"7657",leadTitle:null,fullTitle:"Exergy and Its Application - Toward Green Energy Production and Sustainable Environment",title:"Exergy and Its Application",subtitle:"Toward Green Energy Production and Sustainable Environment",reviewType:"peer-reviewed",abstract:'Exergy has been defined as the maximum work that is useful, extracted from any process toward its equilibrium. Hence, it has a very strong connection with the second law of thermodynamics. In energy harvesting and management systems, the concept of exergy is very important because it represents the efficiency of the system. Exergy can be used as a tool to measure resource efficiency, as well as whole system sustainability. In addition, it can also be used to analyze and clarify the performance of each process; hence, methods of improvement can be determined.This book is the result of a very careful selection of chapters and contributors in the related field. The book is divided into three main sections according to the approaches and purpose of each proposed chapter. The first section is an introduction to the book. The second section, "Advanced energy conversions", describes several advanced technologies that are considered to have great potential in energy conversion and harvesting, and comprises three chapters focusing on photovoltaic/thermal systems with nanofluid, power-to-gas energy storage systems coupled with a combined cycle employing chemical looping combustion technology, and electromagnetic-based power generation. The third section focuses on the idea of "innovative energy management systems" toward high-quality energy systems. In this section, two different chapters describe the introduction of electric vehicles for demand-side energy management and the utilization of supercapacitors for very responsive energy storage in low-power modules. It is expected that this book will provide and enrich the state of the art in advanced energy systems, including energy conversion and management. All the chapters cover a broad range of disciplines, which are correlated in terms of the efforts toward efficient energy systems. In addition, the correlation between energy and exergy, and their understanding, are believed to be very important to improve energy efficiency and guarantee better energy quality.',isbn:"978-1-78984-675-1",printIsbn:"978-1-78984-674-4",pdfIsbn:"978-1-78985-353-7",doi:"10.5772/intechopen.77461",price:119,priceEur:129,priceUsd:155,slug:"exergy-and-its-application-toward-green-energy-production-and-sustainable-environment",numberOfPages:108,isOpenForSubmission:!1,isInWos:null,hash:"16fc8afa11f1219fb17e2482de73edd4",bookSignature:"Muhammad Aziz",publishedDate:"December 4th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7657.jpg",numberOfDownloads:2212,numberOfWosCitations:0,numberOfCrossrefCitations:1,numberOfDimensionsCitations:3,hasAltmetrics:1,numberOfTotalCitations:4,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"November 7th 2018",dateEndSecondStepPublish:"March 6th 2019",dateEndThirdStepPublish:"May 5th 2019",dateEndFourthStepPublish:"July 24th 2019",dateEndFifthStepPublish:"September 22nd 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,editors:[{id:"98160",title:"Associate Prof.",name:"Muhammad",middleName:null,surname:"Aziz",slug:"muhammad-aziz",fullName:"Muhammad Aziz",profilePictureURL:"https://mts.intechopen.com/storage/users/98160/images/system/98160.jpeg",biography:"Dr. Aziz is currently an Associate Professor at the Institute of Industrial Science, The University of Tokyo, Tokyo, Japan. He received B. Eng., M. Eng., and D. Eng. degrees from Kyushu University, Japan, in 2004, 2006 and 2008, respectively, in the field of mechanical engineering. He was working previously as associate professor (2015-2019) and assistant professor (2011-2015) at Tokyo Institute of Technology, a researcher at Institute of Industrial Science, The University of Tokyo (2009-2011), mechanical designer at Seiko Epson Corp. (2008-2009), and lecturer at Ritsumeikan Asia Pacific University (2007-2008). In April 2019, he moved to The University of Tokyo holding the current position. His general research areas are advanced energy conversion systems. His research interest includes power generation, renewable energy utilization, process modeling, smart grid, electric vehicle, battery, and hydrogen production and utilization. He has published more than 125 peer-reviewed journals, 20 books and book chapters, and more than 200 proceedings. In addition, he is also active as a reviewer for more than 50 distinguished journals related to energy research.",institutionString:"Tokyo Institute of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Tokyo",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"773",title:"Thermal Engineering",slug:"engineering-energy-engineering-thermal-engineering"}],chapters:[{id:"69761",title:"Introductory Chapter: Green Energy Systems",doi:"10.5772/intechopen.89925",slug:"introductory-chapter-green-energy-systems",totalDownloads:242,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Muhammad Aziz",downloadPdfUrl:"/chapter/pdf-download/69761",previewPdfUrl:"/chapter/pdf-preview/69761",authors:[{id:"98160",title:"Associate Prof.",name:"Muhammad",surname:"Aziz",slug:"muhammad-aziz",fullName:"Muhammad Aziz"}],corrections:null},{id:"66594",title:"Chemical Looping Combustion Power Generation System for a Power‐to‐Gas Scheme",doi:"10.5772/intechopen.85584",slug:"chemical-looping-combustion-power-generation-system-for-a-power-to-gas-scheme",totalDownloads:490,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Muhammad W. Ajiwibowo, Arif Darmawan and Muhammad Aziz",downloadPdfUrl:"/chapter/pdf-download/66594",previewPdfUrl:"/chapter/pdf-preview/66594",authors:[{id:"98160",title:"Associate Prof.",name:"Muhammad",surname:"Aziz",slug:"muhammad-aziz",fullName:"Muhammad Aziz"},{id:"287852",title:"Mr.",name:"Muhammad W.",surname:"Ajiwibowo",slug:"muhammad-w.-ajiwibowo",fullName:"Muhammad W. Ajiwibowo"},{id:"287854",title:"Mr.",name:"Arif",surname:"Darmawan",slug:"arif-darmawan",fullName:"Arif Darmawan"}],corrections:null},{id:"66854",title:"Exergy in Photovoltaic/Thermal Nanofluid-Based Collector Systems",doi:"10.5772/intechopen.85431",slug:"exergy-in-photovoltaic-thermal-nanofluid-based-collector-systems",totalDownloads:389,totalCrossrefCites:1,totalDimensionsCites:3,signatures:"Amin Farzanehnia and Mohammad Sardarabadi",downloadPdfUrl:"/chapter/pdf-download/66854",previewPdfUrl:"/chapter/pdf-preview/66854",authors:[{id:"292362",title:"Dr.",name:"Mohammad",surname:"Sardarabadi",slug:"mohammad-sardarabadi",fullName:"Mohammad Sardarabadi"},{id:"293237",title:"Mr.",name:"Amin",surname:"Farzanehnia",slug:"amin-farzanehnia",fullName:"Amin Farzanehnia"}],corrections:null},{id:"66565",title:"Electrical Vehicle-Assisted Demand Side Energy Management",doi:"10.5772/intechopen.85862",slug:"electrical-vehicle-assisted-demand-side-energy-management",totalDownloads:314,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Xing Luo, Xu Zhu and Eng Gee Lim",downloadPdfUrl:"/chapter/pdf-download/66565",previewPdfUrl:"/chapter/pdf-preview/66565",authors:[{id:"37564",title:"Dr.",name:"Xu",surname:"Zhu",slug:"xu-zhu",fullName:"Xu Zhu"},{id:"61533",title:"Prof.",name:"Eng Gee",surname:"Lim",slug:"eng-gee-lim",fullName:"Eng Gee Lim"},{id:"287498",title:"M.Sc.",name:"Xing",surname:"Luo",slug:"xing-luo",fullName:"Xing Luo"}],corrections:null},{id:"68430",title:"Supercapacitors as Guarantors for Energy Sustainability in Low-Power Energy Harvesting Sensor Modules",doi:"10.5772/intechopen.88007",slug:"supercapacitors-as-guarantors-for-energy-sustainability-in-low-power-energy-harvesting-sensor-module",totalDownloads:400,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Dalibor Purkovic",downloadPdfUrl:"/chapter/pdf-download/68430",previewPdfUrl:"/chapter/pdf-preview/68430",authors:[{id:"295933",title:"M.Sc.",name:"Dalibor",surname:"Purkovic",slug:"dalibor-purkovic",fullName:"Dalibor Purkovic"}],corrections:null},{id:"66600",title:"Energy Management through Electromagnetic Conversion",doi:"10.5772/intechopen.85420",slug:"energy-management-through-electromagnetic-conversion",totalDownloads:382,totalCrossrefCites:0,totalDimensionsCites:0,signatures:"Eduardo Torres-Sánchez",downloadPdfUrl:"/chapter/pdf-download/66600",previewPdfUrl:"/chapter/pdf-preview/66600",authors:[{id:"285428",title:"Dr.",name:"Eduardo",surname:"Torres-Sánchez",slug:"eduardo-torres-sanchez",fullName:"Eduardo Torres-Sánchez"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},relatedBooks:[{type:"book",id:"3072",title:"Mass Transfer",subtitle:"Advances in Sustainable Energy and Environment Oriented Numerical Modeling",isOpenForSubmission:!1,hash:"11ea46b65df067928b6e0c012fca735a",slug:"mass-transfer-advances-in-sustainable-energy-and-environment-oriented-numerical-modeling",bookSignature:"Hironori Nakajima",coverURL:"https://cdn.intechopen.com/books/images_new/3072.jpg",editedByType:"Edited by",editors:[{id:"45206",title:"Dr.",name:"Hironori",surname:"Nakajima",slug:"hironori-nakajima",fullName:"Hironori Nakajima"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"900",title:"Thermal Power Plants",subtitle:null,isOpenForSubmission:!1,hash:"9cd70196c2a6bf83de6eac762ad73ed2",slug:"thermal-power-plants",bookSignature:"Mohammad Rasul",coverURL:"https://cdn.intechopen.com/books/images_new/900.jpg",editedByType:"Edited by",editors:[{id:"68665",title:"Dr.",name:"Mohammad",surname:"Rasul",slug:"mohammad-rasul",fullName:"Mohammad Rasul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6575",title:"Bringing Thermoelectricity into Reality",subtitle:null,isOpenForSubmission:!1,hash:"7093275b866334e0eaa82eb3e5b046f5",slug:"bringing-thermoelectricity-into-reality",bookSignature:"Patricia Aranguren",coverURL:"https://cdn.intechopen.com/books/images_new/6575.jpg",editedByType:"Edited by",editors:[{id:"188620",title:"Dr.",name:"Patricia",surname:"Aranguren",slug:"patricia-aranguren",fullName:"Patricia Aranguren"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3385",title:"Thermal Power Plants",subtitle:"Advanced Applications",isOpenForSubmission:!1,hash:"79a440454d0d4636b47cb20c1fe756b2",slug:"thermal-power-plants-advanced-applications",bookSignature:"Mohammad Rasul",coverURL:"https://cdn.intechopen.com/books/images_new/3385.jpg",editedByType:"Edited by",editors:[{id:"68665",title:"Dr.",name:"Mohammad",surname:"Rasul",slug:"mohammad-rasul",fullName:"Mohammad Rasul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6469",title:"Application of Exergy",subtitle:null,isOpenForSubmission:!1,hash:"0836749bb350a373d5e2628c73539698",slug:"application-of-exergy",bookSignature:"Tolga Taner",coverURL:"https://cdn.intechopen.com/books/images_new/6469.jpg",editedByType:"Edited by",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7272",title:"Advanced Cooling Technologies and Applications",subtitle:null,isOpenForSubmission:!1,hash:"540cb9c921dadbc8230afd4390eb8248",slug:"advanced-cooling-technologies-and-applications",bookSignature:"S. M. Sohel Murshed",coverURL:"https://cdn.intechopen.com/books/images_new/7272.jpg",editedByType:"Edited by",editors:[{id:"24904",title:"Prof.",name:"S. M. Sohel",surname:"Murshed",slug:"s.-m.-sohel-murshed",fullName:"S. M. Sohel Murshed"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8394",title:"Low-temperature Technologies",subtitle:null,isOpenForSubmission:!1,hash:"be68d10255b1c1c72aef7caddf946e34",slug:"low-temperature-technologies",bookSignature:"Tatiana Morosuk and Muhammad Sultan",coverURL:"https://cdn.intechopen.com/books/images_new/8394.jpg",editedByType:"Edited by",editors:[{id:"193888",title:"Prof.",name:"Tatiana",surname:"Morosuk",slug:"tatiana-morosuk",fullName:"Tatiana Morosuk"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7217",title:"Organic Rankine Cycle Technology for Heat Recovery",subtitle:null,isOpenForSubmission:!1,hash:"c9f91d2615f45f47fe9537b174e9cd87",slug:"organic-rankine-cycle-technology-for-heat-recovery",bookSignature:"Enhua Wang",coverURL:"https://cdn.intechopen.com/books/images_new/7217.jpg",editedByType:"Edited by",editors:[{id:"199752",title:"Dr.",name:"Enhua",surname:"Wang",slug:"enhua-wang",fullName:"Enhua Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7487",title:"Thermal Energy Battery with Nano-enhanced PCM",subtitle:null,isOpenForSubmission:!1,hash:"a917c6664886ab78f757aeb59f45635d",slug:"thermal-energy-battery-with-nano-enhanced-pcm",bookSignature:"Mohsen Sheikholeslami Kandelousi",coverURL:"https://cdn.intechopen.com/books/images_new/7487.jpg",editedByType:"Edited by",editors:[{id:"185811",title:"Dr.",name:"Mohsen",surname:"Sheikholeslami Kandelousi",slug:"mohsen-sheikholeslami-kandelousi",fullName:"Mohsen Sheikholeslami Kandelousi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7659",title:"Organic Rankine Cycles for Waste Heat Recovery",subtitle:"Analysis and Applications",isOpenForSubmission:!1,hash:"98c4b304e87fd0d4e56579783f22a1f7",slug:"organic-rankine-cycles-for-waste-heat-recovery-analysis-and-applications",bookSignature:"Silvia Lasala",coverURL:"https://cdn.intechopen.com/books/images_new/7659.jpg",editedByType:"Edited by",editors:[{id:"190049",title:"Dr.",name:"Silvia",surname:"Lasala",slug:"silvia-lasala",fullName:"Silvia Lasala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"66064",slug:"corrigendum-to-textured-bst-thin-film-on-silicon-substrate-preparation-and-its-applications-for-high",title:"Corrigendum to: Textured BST Thin Film on Silicon Substrate: Preparation and Its Applications for High Frequency Tunable Devices",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/66064.pdf",downloadPdfUrl:"/chapter/pdf-download/66064",previewPdfUrl:"/chapter/pdf-preview/66064",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/66064",risUrl:"/chapter/ris/66064",chapter:{id:"62285",slug:"textured-bst-thin-film-on-silicon-substrate-preparation-and-its-applications-for-high-frequency-tuna",signatures:"Congchun Zhang, Jianze Huang, Chunsheng Yang and Guifu Ding",dateSubmitted:"February 7th 2018",dateReviewed:"June 3rd 2018",datePrePublished:"November 5th 2018",datePublished:"January 3rd 2019",book:{id:"7253",title:"Coatings and Thin-Film Technologies",subtitle:null,fullTitle:"Coatings and Thin-Film Technologies",slug:"coatings-and-thin-film-technologies",publishedDate:"January 3rd 2019",bookSignature:"Jaime Andres Perez-Taborda and Alba G. Avila Bernal",coverURL:"https://cdn.intechopen.com/books/images_new/7253.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193020",title:"Dr.",name:"Jaime Andres",middleName:null,surname:"Perez Taborda",slug:"jaime-andres-perez-taborda",fullName:"Jaime Andres Perez Taborda"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"33329",title:"Prof.",name:"guifu",middleName:null,surname:"Ding",fullName:"guifu Ding",slug:"guifu-ding",email:"gfding@sjtu.edu.cn",position:null,institution:{name:"Shanghai Jiao Tong University",institutionURL:null,country:{name:"China"}}},{id:"244624",title:"Associate Prof.",name:"Congchun",middleName:null,surname:"Zhang",fullName:"Congchun Zhang",slug:"congchun-zhang",email:"zhcc@sjtu.edu.cn",position:null,institution:null},{id:"255541",title:"Mr.",name:"Jianze",middleName:null,surname:"Huang",fullName:"Jianze Huang",slug:"jianze-huang",email:"huangjz420@sjtu.edu.cn",position:null,institution:null},{id:"255547",title:"Mr.",name:"Chunsheng",middleName:null,surname:"Yang",fullName:"Chunsheng Yang",slug:"chunsheng-yang",email:"csyang@sjtu.edu.cn",position:null,institution:null}]}},chapter:{id:"62285",slug:"textured-bst-thin-film-on-silicon-substrate-preparation-and-its-applications-for-high-frequency-tuna",signatures:"Congchun Zhang, Jianze Huang, Chunsheng Yang and Guifu Ding",dateSubmitted:"February 7th 2018",dateReviewed:"June 3rd 2018",datePrePublished:"November 5th 2018",datePublished:"January 3rd 2019",book:{id:"7253",title:"Coatings and Thin-Film Technologies",subtitle:null,fullTitle:"Coatings and Thin-Film Technologies",slug:"coatings-and-thin-film-technologies",publishedDate:"January 3rd 2019",bookSignature:"Jaime Andres Perez-Taborda and Alba G. Avila Bernal",coverURL:"https://cdn.intechopen.com/books/images_new/7253.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193020",title:"Dr.",name:"Jaime Andres",middleName:null,surname:"Perez Taborda",slug:"jaime-andres-perez-taborda",fullName:"Jaime Andres Perez Taborda"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"33329",title:"Prof.",name:"guifu",middleName:null,surname:"Ding",fullName:"guifu Ding",slug:"guifu-ding",email:"gfding@sjtu.edu.cn",position:null,institution:{name:"Shanghai Jiao Tong University",institutionURL:null,country:{name:"China"}}},{id:"244624",title:"Associate Prof.",name:"Congchun",middleName:null,surname:"Zhang",fullName:"Congchun Zhang",slug:"congchun-zhang",email:"zhcc@sjtu.edu.cn",position:null,institution:null},{id:"255541",title:"Mr.",name:"Jianze",middleName:null,surname:"Huang",fullName:"Jianze Huang",slug:"jianze-huang",email:"huangjz420@sjtu.edu.cn",position:null,institution:null},{id:"255547",title:"Mr.",name:"Chunsheng",middleName:null,surname:"Yang",fullName:"Chunsheng Yang",slug:"chunsheng-yang",email:"csyang@sjtu.edu.cn",position:null,institution:null}]},book:{id:"7253",title:"Coatings and Thin-Film Technologies",subtitle:null,fullTitle:"Coatings and Thin-Film Technologies",slug:"coatings-and-thin-film-technologies",publishedDate:"January 3rd 2019",bookSignature:"Jaime Andres Perez-Taborda and Alba G. Avila Bernal",coverURL:"https://cdn.intechopen.com/books/images_new/7253.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"193020",title:"Dr.",name:"Jaime Andres",middleName:null,surname:"Perez Taborda",slug:"jaime-andres-perez-taborda",fullName:"Jaime Andres Perez Taborda"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"8795",leadTitle:null,title:"Reptiles",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.",isbn:"978-1-78985-492-3",printIsbn:"978-1-78985-491-6",pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,hash:"839705a75a74ec1ee60f481628d59046",bookSignature:"",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/8795.jpg",keywords:null,numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"July 11th 2018",dateEndSecondStepPublish:"August 1st 2018",dateEndThirdStepPublish:"September 30th 2018",dateEndFourthStepPublish:"December 19th 2018",dateEndFifthStepPublish:"February 17th 2019",remainingDaysToSecondStep:"3 years",secondStepPassed:!0,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"5",title:"Agricultural and Biological Sciences",slug:"agricultural-and-biological-sciences"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"6418",title:"Hyperspectral Imaging in Agriculture, Food and Environment",subtitle:null,isOpenForSubmission:!1,hash:"9005c36534a5dc065577a011aea13d4d",slug:"hyperspectral-imaging-in-agriculture-food-and-environment",bookSignature:"Alejandro Isabel Luna Maldonado, Humberto Rodríguez Fuentes and Juan Antonio Vidales Contreras",coverURL:"https://cdn.intechopen.com/books/images_new/6418.jpg",editedByType:"Edited by",editors:[{id:"105774",title:"Prof.",name:"Alejandro Isabel",surname:"Luna Maldonado",slug:"alejandro-isabel-luna-maldonado",fullName:"Alejandro Isabel Luna Maldonado"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophanides",surname:"Theophile",slug:"theophanides-theophile",fullName:"Theophanides Theophile"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"56597",title:"Metallothioneins, Saccharomyces cerevisiae, and Heavy Metals: A Biotechnology Triad?",doi:"10.5772/intechopen.70340",slug:"metallothioneins-saccharomyces-cerevisiae-and-heavy-metals-a-biotechnology-triad-",body:'Biotechnology, which makes use of living organisms for technological purposes, is one of the applied fields that constantly benefited from the rapid advancements made in understanding life at molecular level. It is undoubtedly that the budding yeast
Metallothioneins (MTs) represent one of the numerous examples of proteins whose functions were investigated by heterologous expression in
Heavy metals belong to a group of nondegradable chemicals naturally present in the environment. Numerous anthropogenic activities, especially the ones related to massive industrialization, intensive agriculture, or rapid urbanization led to important perturbations (accumulation, or in some cases, depletion) in heavy metal balance, with ecological, nutritional, and environmental impacts [4–10]. Some of the heavy metals (Co, Cu, Fe, Mn, Ni, and Zn) are essential for life in trace amounts, playing a pivotal role in the structure of enzymes and other proteins. Other heavy metals (Cd, Sb, Cr, Pb, As, Co, Ag, Se, and Hg) albeit not essential, interfere easily with the metabolism of essential heavy metals, competing for the various physiological transport systems as well as for the biomolecules they bind to. Essential or not, when present in high concentrations, heavy metals are strongly deleterious to living organisms due to nonspecific binding to proteins, often inducing oxidative stress, or disrupting biological membranes. Defense mechanisms against nonphysiological concentrations of heavy metal ions include excretion, compartmentalization in cell organelles, or increased synthesis of metal-buffering molecules, such as the MTs.
Apart from being classified on the basis of their structural homology or on taxonomic criteria, MTs are also classified on molecular functionality grounds, starting from their innate metal-binding abilities, into Cu(I)- and Zn(II)-thioneins, with the representative nonessential models Ag(I) and Cd(II), respectively [3, 17]. This is based on the formation of homometallic MT species when they are produced in metal-enriched media; this classification is not regarded as absolute, since cross-affinity is often noticed for Zn(II)-thioneins binding Cu(I) and vice versa [3].
Considered a secondary copper-resistant agent in
Following the discovery and characterization of Cup1, many newly discovered MTs were characterized by heterologous expression in
MT expressed | Source organism | Behavior in | Reference |
---|---|---|---|
Model plant organisms, metal nonaccumulator | Complement Cu(II) and Cd(II) sensitivity of a | [29, 30] | |
Technical plant: biofuel production | Complements Cu(II) and Cd(II) sensitivity of a | [31] | |
Technical plant: nutritional oil. Seeds tend to accumulate Cd(II), Pb(II), and Hg(II) | Complement Cu (II) (all), Cd(II) ( | [32, 33] | |
Cd(II)/Zn(II) hyperaccumulator | [35] | ||
Cu(II)-hypertolerant plant | Restore Cd(II) and Cu(II) tolerance to yeast sensitive strains | [36, 37] | |
Confers tolerance to Cd(II), H2O2, and ethanol | [38] | ||
Confers tolerance to Zn(II) | [39] | ||
Confers vigorous growth under surplus CuCl2, FeCl2, NaCl, NaHCO3, and H2O2 | [40] | ||
Alkaline/saline tolerant grass | Tolerance to H2O2, NaCl, NaHCO3, Zn(II), Fe(II), Fe(III), Cd(II), Cr(VI), and Ag(I); sensitivity to Mn(II), Co(II), Cu(II), Ni(II) | [41] | |
Alkaline tolerant grass | Tolerance to salinity, alkaline conditions, and oxidative stress | [42] | |
Alkaline/saline tolerant plant | Tolerance to Cd(II), Zn(II), Cu(II), and NaCl stresses; increased accumulation of Cd(II), Zn(II), NaCl, but not of Cu(II) | [43] | |
Arbuscular mycorrhizal fungus; confers heavy metal tolerance to exposed plants | Complements Cu(II) and Cd(II) sensitivity of a | [44] | |
Ectomycorrhizal fungus; confers heavy metal tolerance to exposed plants | Complement Cu(II) and Cd(II) sensitivity of | [45] | |
Ectomycorrhizal fungus; confers heavy metal tolerance to exposed plants | Complements Cu(II) and Cd(II), but not Zn(II) sensitivity. | [46] | |
Complement Cu(II) sensitivity | [47] | ||
Growth inhibitory factor (GIF) | Confers metal resistance to yeast cells | [48] | |
Canonical Zn(II)-thionein | Complements Zn(II) sensitivity | [33] | |
Clonable tag for electron microscopy | [82] | ||
Increased Cu(II) tolerance and capacity to remove Cu(II) when expressed from yeast | [72] |
Heterologous expression of MTs in
In plants, the first evidence for the role of MTs in Cu(II) and Cd(II) tolerance was provided by expressing two
Other MTs studied in yeast were isolated from heavy metal hypertolerant or hyperaccumulating plants. Hyperaccumulating plants belong to a small group of species capable of growing on metalliferous soils without developing toxicity symptoms [34]. The MTs from the intensively studied hyperaccumulator
Expression of plant MTs in
Often, plants acquire heavy metal tolerance when growing on contaminated sites due to symbiosis with the radicular, arbuscular mycorrhizal fungi that penetrate the cortical cells of the roots of a vascular plant; one MT isolated from such fungus,
Studies on animal MTs expressed in yeast are less numerous [33, 47, 48, 72] and are used mainly for technical purposes. One notable example though is mouse
The main function of MTs resides in their structure: small proteins with a significant number of cysteine residues (15–30% of the total amino acid number) [53], a characteristic that confers them a remarkable capacity to bind heavy metal ions by forming metal-thiolate clusters. MTs are natively bound to Cu(I) or Zn(II), exhibiting various affinities for the two metals, in between the canonical Cu(I)-thionein (
With high thermodynamic stability combined with kinetic lability, MTs are important candidates for biotechnology applications. In the nonmetalate form, MTs are highly reactive and can virtually bind to any d10 metal [53], a trait that makes them interesting candidates for biotechnology. In this case, two aspects of MT reactivity are highly relevant: (1) metal uptake and release and (2) metal exchange [54]. Due to the polydentate thiolate nature of all MTs and their high affinity for most heavy metal ions, there are data available for binding of Cu(I), Cu(II), Cd(II), Hg(II), Ag(I), Au(I), Bi(III), As(III), Co(II), Fe(II), Pb(II), Pt(II), and Tc(IV) [55]. Another important feature of MT reactivity is the dynamic behavior, with metal uptake and release between species of different degrees of metalation. It is widely accepted that the binding of metal ions to MTs occurs rapidly, between 10 and 30 min, although longer stabilization times are required for certain ions, such as Hg(II) or Pb(II) [3].
Studies on metal exchange in MTs have also been done (usually with either Zn(II)- or Cu(I)-thioneins), starting with a metal-loaded MT forced to exchange its initially bound metal ions with other ions. Considering the series of affinity order of heavy metal ions for the thiolate ligands: Fe(II) ≈ Zn(II) ≈ Co(II) < Pb(II) < Cd(II) < Cu(I) < Au(I) ≈ Ag(I) < Hg(II) < Bi(III) [56], the Zn(II)-loaded MTs would be more reactive than Cu(I)-loaded MTs. It was noted that metal exchange occurs at a much slower pace than metal binding to apo-MTs. For example, it was revealed that binding of four equivalents of Cu(I) to Zn(II)-Cup1 required a stabilization time of 24 h to produce a mixture of Cu4-Cup1 and Cu8-Cup1 species by total displacement of the initially bound Zn(II) [3, 57]. It is interesting to note that many xenobiotic metal ions (Cd(II), Pb(II), and Hg(II)) show higher affinity for thiolate ligands than Zn(II) or Cu(I) does, and thus, in case of intoxication, MTs can work as detoxifying agents [53]. This is highly relevant especially when designing a biotechnology system aimed for removal of toxic ions, as in the case of bioremediation. In the following paragraph, studies on metal accumulation by MTs expressing
Metal investigated | Expressed MT | MT provenience | Yeast gained characteristics due to expression of MT | Reference |
---|---|---|---|---|
Cd(II) | Cup1/His6 Yeast surface display | Cd(II) tolerance, Cd(II) increased adsorption; selectivity against Cu(II) | [66] | |
Cd(II) | Δ1–8Cup1 (Δ1–8Cup1)4 (Δ1–8Cup1)8 Surface display of tandem repeats of head-to-tail yeast MT lacking the first 8 amino acids | Cd(II) tolerance and adsorption were dependent on the number of tandem repeats; 4 and 8 repeats determined increased Cd(II) adsorption/recovery 5.9 and 8.9 times, respectively | [67] | |
Cd(II) | Yeast surface display | (Cd(II)/Zn(II) hyperaccumulator) | Increased Cd(II) tolerance and adsorption; concentration of Cd(II) from ultra-trace media; selectivity to Cd(II) against Cu(II) and Hg(II) | [69] |
Cd(II) | (Cd/Zn hyperaccumulator) | Increased Cd(II) tolerance and accumulation | [76] | |
Cd(II) | Alkaline/saline tolerant plant | Increased Cd(II) tolerance and accumulation | [43] | |
Cu(II) | hMT2, GFP-hMT2 | Increased Cu(II) tolerance and capacity to remove Cu(II) when expressed from yeast | [72] | |
Zn(II) | Increased accumulation of Zn(II) | [30] | ||
Zn(II) | Alkaline/saline tolerant plant | Increased Zn(II) tolerance and accumulation | [43] |
MTs heterologously expressed in yeast that determine increased accumulation of metal ions.
Cell surface engineering has wide applicability due to the fact that virtually any protein can be produced and autoimmobilized on the cell exterior of an engineered cell (usually a microorganism).
Adsorption of heavy metal ions at the cell surface has certain advantages compared to intracellular accumulation. First, surface adsorption allows recycling of the adsorbed ions, whereas intracellular accumulation necessitates disintegration of the cell for extraction. Second, surface adsorption is possible even in nonviable cells, providing that sufficient biomass can be produced. This is particularly important when cells are used to remove heavy metals from contaminated waters, and the conditions necessary to sustain living cells are difficult to achieve. And third, surface-engineered yeast cells can be used repeatedly as bioadsorbents since the recovery and treatment of the heavy metal ions does not greatly damage the cells [66]. In a sequel study, Cup1 was expressed as tandem head-to-tail repeats of the yeast MT lacking the first 8 amino acids (known to be nonsignificant for metal binding). Three types of constructs that were surface displayed contained 1, 4, and 8 tandem MT repeats [67].
The transgenic cells obtained were tested against excess Cd(II), and it was revealed that the adsorption and recovery of Cd(II) on the cell surface was increasingly enhanced with increasing the number of tandem repeats under conditions that allowed complete occupation of the Cd(II)-binding sites in the MT tandem repeats. Considering the relationship between cell-surface adsorption and protection against heavy metal ion toxicity, the tolerance of these surface-engineered yeasts to Cd(II) was found to be also dependent on the number of displayed MT tandem repeats, indicating that the characteristics of surface-engineered yeasts as a bioadsorbents correlated with the ability of the displayed proteins to bind metal ions [67]. Unfortunately, these promising studies soon came to a halt and no other metal ions or other MTs were taken into consideration to be used in this technique. It took ten years before another group displayed at the surface of yeast cells four type-2 MTs from
Heavy metal bioremediation is an appealing approach for decontaminating polluted environments, especially because standard physico-chemical methods are ineffective and very often a source of pollution themselves [5]. An ideal heavy metal bioremediator would have certain metal-related characteristics: tolerance to high concentrations, increased accumulation, and substantial biomass production for effective removal of heavy metal ions from the contaminated sites. These traits fall into the characteristics of the heavy metal hyperaccumulating plants, with the exception that they usually do not produce sufficient biomass [70].
The natural heavy metal hyperaccumulators, mostly belonging to a small group of plants [34, 70], are the species whose metal-related characteristics initially prompted the ideas of bioremediation, biomining, and bioextraction. To accumulate heavy metals without developing toxicity symptoms, these organisms utilize a variety of chemical ligands capable of coordinating the metal ions in a nontoxic form. Although MTs are important candidates for sequestering heavy metal ions, the studies relevant for correlating MT expression with heavy metal accumulating phenotype are scarce and hardly encouraging [74, 75]. The examples of MT from hyperaccumulating organisms expressed in yeast are few, and they mainly focus on functional complementation tests [33, 36–38, 69, 76]. One example is worth mentioning here though, as it deals with an unusual hyperaccumulating phenotype: Ag(I)-hyperaccumulation due to three distinct MT genes of the ectomycorrhizal fungus
Due to their small size and metal-binding capacity, metallothioneins may be interesting candidates for tagging proteins for imaging, especially by electron microscopy (EM) [79–81]. Localization of proteins in cells or complexes using EM relies upon the use of heavy metal clusters, which can be difficult to direct to sites of interest. For this reason, a metal-binding clonable tag, such as it is green fluorescent protein (GFP) for light microscopy, has been pursued for a long time, and would be unvaluable for imaging by EM techniques. In this respect, MT is a very good candidate, because instead of fluorescing like GFP, it would initiate formation of a heavy metal cluster adjacent to the protein to be analyzed. A suitable clonable tag for EM is expected to have certain properties: small size and low molecular weight, so as not to disrupt protein kinetics/function
The numerous studies on MTs stand for the uniqueness of these small proteins whose undisputed trait is binding to heavy metal ions. This is evidently due to the cysteinyl residues, which represent more than 20% of the total number of MT amino acids, whereas the usual percentage of cysteinyl residues seldom surpasses 5% in most proteins. The intrinsic characteristic of sequestering metal ions in thiolate clusters make MTs very interesting biomolecules for various biotechnological application. Since
The authors received funding from the Romanian—EEA Research Programme operated by the Ministry of National Education under the EEA Financial Mechanism 2009–2014 and Project Contract No 21 SEE/30.06.2014.
Human trafficking is a global issue that affects people from virtually every part of the world. Though statistics on the extent of the crime is hard to prove, anecdotal reports suggest that it is increasing [1]. For instance, more than 500 different trafficking flows were detected between 2012 and 2014 across the globe [1]. Similarly, from a recent global survey on human trafficking published by International Labour Organization (ILO) and the Walk Free Foundation, an estimated 40.3 million people were reported to be in modern slavery in 2017 [2]. While the total annual revenue accruing from human trafficking varies, depending on the source, but it is estimated to be between US$ 5 and US$42 billion [3].
Although human trafficking is common in different continents of the world, it is endemic in Africa. Africa has been bedevilled with a number of crisis, including high levels of unemployment, poverty, hunger, corruption, political and economic instabilities, to mention a few [4, 5]. These problems are exacerbated by tensions and insurrections, which have led to internal displacements of people. The quest for survival in the midst of these socio-political and economic crises have engendered high migration flow from one African State to another; from one African region to another, and from Africa to other continents. While some migration activities are legal, many others are carried out illegally. Meanwhile criminals regularly deceive migrants and traffick them into a world of different dimensions of exploitation. While the exact numbers and demographics of trafficked persons from Africa are unknown, the United Nations Office on Drugs and Crime (UNODC) reports often provide guestimates of the realities [6]. For instance, according to UNODC report in 2016, a total of 69 countries detected human trafficking victims from Sub-Saharan Africa between 2012 and 2014 [1].
The scale of human trafficking in Africa came from alarm raised by activists, civil societies and Non-Governmental Organisations (NGOs), especially in Nigeria, Togo, South Africa, Benin Republic, to mention a few in the latter 1990s [7, 8, 9, 10]. For instance, anecdotal reports indicated that human trafficking in West Africa has assumed alarming proportion since the mid-1990s [8, 11, 12]. Child trafficking also became prominent in West Africa when international media focused on the exposure of a ship code-named
The purpose of this chapter is to discuss the nature, extent and the complexities of human trafficking in Africa. It draws from a review of literature on human trafficking in different parts of Africa and beyond. The chapter begins with the conceptualisation of human trafficking, and moves onto an overview of human trafficking in Africa; the factors engendering human trafficking in Africa, and suggestions for effective response to it.
Defining human trafficking is relatively contentious [2, 11, 14, 15]. Part of the controversy revolves around the array of activities that are involved in it. This could be part of the reasons why Gould [16] described it as ‘a slipping concept’ that is very difficult to pin down. Moreover, the controversy between traditional practices and modernisation sometimes blur the understanding and definition of the concept. Portrayals of human trafficking in Western democracies may be different from that of Africa [6]. For instance, a child hawking goods in public could be construed as a form of exploitation, but in some Western African societies, it could be part of the routines of a child in order to assist his/her parents [11].
The definition of human trafficking varies from scholar to scholar, and country to country. Most of the debates are rooted in divergent worldview, historical backgrounds and findings from studies conducted by scholars [17]. Trafficking in persons (human trafficking) is defined in article 2(a) of the 2000
For the purpose of this article, human trafficking is defined as the deception, recruitment, transportation and transfer of persons, for the purpose of exploitation.
The end of the Cold War resulted in the rise of regional conflicts in Africa and the decline of borders, leading to an increased number of economic and political refugees [18, 19]. Since then, the rates of human trafficking in different parts of Africa have also increased considerably due to capacity gaps in the management of sub-regional economic cooperation and regional integration initiatives among African states [18]. This situation led to several interventions by policy makers and other stakeholders at the continental, regional and national levels. However, many African countries are still finding it very challenging to combat human trafficking due to ineffective policies and capacity, even where legislation is in place. The combination(s) of lack of political will, political and institutional corruption, and a range of other underlying perennial socio-economic problems that these countries are confronted with have made the fight against human trafficking almost insurmountable [7, 18].
Human trafficking is a dynamic phenomenon with a range of interlocking forces, factors and processes [6]. Trafficking issues and challenges often revolve around three variables, (though with two extreme ends)—the demand for cheap labour and exploitation on one hand, and the willingness to meet basic economic needs for survival on the other ([20], p. 7). It will be erroneous to describe human trafficking essentially as an economic cum security issue, perhaps due to the factors that entrap people into it.
Trafficking features in West Africa is complex, so are its routes. Countries like Nigeria, Ghana, Cameroon and Senegal are source, transit, and destination countries for trafficked women and children [1]. Trafficking of young girls from rural areas in countries such as Mali, Benin, Burkina Faso, Togo, and Ghana to work in Cocoa plantations in Urban Cote D’Ivoire are also documented in literature [1]. Trafficking from and through eastern Nigeria to Gabon have increased in recent years [1]. According to United Nations International Children’s Emergency Fund (UNICEF) 2017 report, children made up over a quarter of detected trafficking victims in the world, and out of this, 64% are from sub-Saharan Africa. This figure would have increased in recent times due to current political and economic challenges in sub-Saharan Africa that have compelled several people, including women and children to leave their homes in search of new opportunities in neighbouring countries [21, 22, 23, 24, 25, 26, 27, 28, 29].
Similar to the experience in West Africa, human trafficking is prevalent in Southern Africa. Countries such as South Africa, Mozambique, Zambia, and Lesotho are source, transit and destination countries for human trafficking [9]. However, unlike the West African scenario where the flow is multidimensional—one country could serve as the source, while another serve as the transit and destination point—trafficking geography in Southern Africa is relatively complicated. It involves complex trafficking flows from diverse countries of origin from Africa and the rest of the world [10]. In this region, South Africa serves as the rallying point. In addition to its status as the powerhouse of the sub-region, South Africa also serves as an economic hub on the African continent. Until recently, has the largest economy in Africa [30], South Africa also serves as a major hub for trade in human commodity [6, 31]. It provides an enabling environment and market for the services of trafficked persons from the regional and extra-regional level [32]. Incessant crises that ravaged the Continent, such as political instabilities, insurrections, poverty, hunger, unemployment, kidnapping, terrorism, amongst others, make South Africa a magnet that attracts migration flows from other African countries [6, 33].
It is imperative to state that in the Southern African axis, South Africa serves mainly as the destination point. This is not to infer that South Africa is not a source or transit country for human trafficking, but as the economic hub of the region, South Africa is the main destination points for Southern African sub regional and extra-regional flows. Within South Africa, women and children are recruited and transported from the rural areas to cities, such as Johannesburg, Pretoria, Bloemfontein, Cape Town and Durban, for exploitation [6]. While most girls work as domestic servants in wealthy homes, majority of the boys serve as street vendors, waiters, beggars on the roads, street urchins, labourers on farm lands and plantations, and for other criminal activities [6].
According to United States Department of State Trafficking in Persons Report [34], West African syndicates dominate and control the commercial sex business in Hillbrow (Johannesburg) and other urban centres across the State, local criminal rings control child prostitution in the country. While Russian and Bulgarian crime syndicates control prostitution business in the Cape Town axis, the Chinese nationals organise and coordinate the sex trafficking of Asian nationals [34].
Children are trafficked to South Africa from Lesotho’s border towns; women and girls trafficked from Mozambique are destined for South Africa’s Gauteng and Kwa-Zulu Natal provinces [10]. In Malawi, women and girls are trafficked to northern Europe and South Africa. In addition to these configurations, women are also trafficked from Thailand, China, and Eastern Europe [35]. Ethnically based criminal syndicates in South Africa’s refugee camps recruit and transport their victims, usually married women from their home countries.
In Lesotho, traffickers often recruit male and female street children, victims of physical and sexual abuse at home, or children orphaned by AIDS [7]. Such children normally migrate from rural areas and border towns to Maseru, the capital, from where they are trafficked by mostly South African white Afrikaans to work in farms in Eastern Cape. In Mozambique, men, women and children are trafficked from Maputo to Durban or Johannesburg for various exploitative purposes. While women and children are trafficked to provide sexual services to miners at West Rand, men are trafficked for labour related task at the mines [7, 35].
In East African axis, Ugandan and Kenyan women are trafficked for prostitution in the Gulf States. The incessant crises in Uganda created an avenue for rebel leaders to kidnap children, young girls and women from the opposition camps [34]. In addition to the locals, victims of trafficking in Uganda are from the Democratic of Congo (Congo DRC), Burundi, Kenya, Tanzania, Rwanda and South Sudan [34]. While girls, young ladies and women are forced into prostitution, boys and men work in agricultural, construction and other labour related industries in Uganda [34] Similarly, Kenya serves as a source, transit and destination country for trafficking of young girls and women to and from Europe [34].
Human trafficking also thrives in North Africa. Virtually all countries in this region of Africa are source, transit and destination countries for trade in human commodity [7]. However, there may be variations in the volume of trafficked victims are transported from and into each of the countries in the region [7]. For instance, Algeria is more of a transit and destination country than a source country, unlike other countries in the region like Egypt, Morocco and Tunisia that are essentially a source, transit and destination countries for human trafficking [34].
Traffickers in this region of Africa target undocumented (illegal) migrants from sub-Saharan Africa, like Mali, Niger, Cameroon and Nigeria. The illegal status of such migrants and language barriers make them vulnerable to various forms of exploitation by traffickers who often deceive them with a view to make them fill the available vacancies in the labour and sexual trafficking industries [6]. Contrastively, illegal migrants often fall prey to traffickers in North Africa while trying to cross the borders of some of the countries in the region en route Europe with the perception of improving their lives. While Europe is their ultimate destination, travelling long distances through the desert, especially Sahara desert en route Europe make them vulnerable to exploitation. Due to the long distances they are to cover, and the cost of transportation, these illegal migrants often run out of money, seek avenues to survive. Traffickers, aware of their vulnerabilities subject them to labour and sexual exploitation (USTIP Report, 2016). In addition, in Egypt (precisely), women and children are vulnerable to labour and sexual exploitation (USTIP Report, 2016). Men from United Arab Emirates (UAE), Kuwait and Saudi Arabia often purchase summer (temporary) marriages for commercial sexual exploitations. There are documentations of child sex tourism in Cairo, Luxor and Alexandria in Egypt (USTIP Report, 2016).
Studies have indicated an increase in migration flows across the world. Most of these flows are largely attributed to myriad of factors ranging from political upheaval, to economic-crises, ethnic discrimination, communal inequalities, civil wars to lack of viable means of livelihood ([7], p. 83; [36], p. 11; [37], p. 7). For people ensnared by hunger and poverty, migration through what Maggy Lee described as ‘irregular channels of smuggling and trafficking’ become an alternative means of survival or an escape route ([37], p. 7).
In Africa, human trafficking is of two dimensions - internal and external trafficking [1, 19]. Although there have been debates on the validity of this assertion, studies on human trafficking have shown that a country could serve as origin (source), transit and destination for trafficking operations [19]. For instance, citizens of countries as Canada, United Kingdom and New Zealand may find it difficult to accept that human trafficking thrives in their countries due to their tight border and sophisticated immigration control, however, studies have shown that virtually all country of the world is implicated in human trafficking web [19].
The market for this criminal trade is wide, owing to the lucrative nature of this business. The markets are often driven by highly sophisticated criminal gangs with network that span across States frontiers. The expansion of global market for trade and investment necessitated an increase in the demand and supply of people ([36], p. 26). Such expansion often culminates in high migration flow, and hibernating in the exodus of these individuals is this illicit trade (human trafficking). Similarly, globalisation created demographic disparities among the less-developed, developing and the developed countries, resulting in what Shelley referred to as ‘the feminization of poverty’ and ‘marginalisation of rural communities’ ([19], p. 3).
Globalisation has been enhanced considerably by the internet and the so called ‘dark web’ [1, 2]. Such platforms have often been exploited by traffickers to advertise and lure people into the trafficking world [2, 19]. Through the internet, several girls and ladies have been lured by traffickers (under the pretext of providing immigration services) to unknown destinations, where they are raped, and exploited [1]. Child pornography, online sex chats and other forms of illicit services, have been rendered by traffickers to different clients across the globe ([36], p. 130). Human trafficking has also been linked with sporting events ([36], p. 141). However, there are arguments and counter-arguments about its actual estimate.
The wave of natural disasters that swept through several countries of the world due to global warming has left many people homeless, displaced and impoverished. Examples of these natural disasters include the tsunami that swept through the Southeast Asian countries, the hurricane Katrina in New Orleans, drought in Sudan, and earthquake in Haiti [36]. Unfortunately, humanitarian responses to most of these emergency situations have often been undermined by corruption [1, 15]. According to Shelley [19] most of the assistance programmes and initiatives to assist disaster victims have largely been inadequate, with most of the needed aid too often, have been diverted by corrupt officials. The combination of the loss of their lands—both commercial lands and residential lands, and the uncertainty of securing any opportunity in other sector of their national economy, these distressed people often become vulnerable, and easy prey for traffickers ([19], p. 38).
In Africa, trafficking in Persons is of two different types. Literatures on the phenomenon suggest the internal and external trafficking [38, 39]. Internal trafficking takes place within a country’s territory (domestic trafficking). It usually takes the form of recruitment and movement of people from the rural to urban centres for various forms of exploitative work and or activities such as: prostitution, forced labour (as domestic servants), factory workers, workers in plantations and construction companies, drug peddlers, pick-pockets, waiters, among several others ([40], p. 4).
In contrast to the internal dimension, international trafficking takes the form of recruitment and movement of people from one country to another (cross-border trafficking) for the purpose of exploitation. The nature of exploitation in this form is also similar to the domestic form but in greater proportion. The demands are higher so also are the costs and implications. For most of the cross-border dimensions, the flows are usually between countries within the same region or neighbouring countries. Thus, the cross-border flow is not usually a distance one. However, there are instances of continental and intercontinental flows as well. According to United Nations Office on Drugs and Crime (UNDOC), contemporarily, there are evidences of victims of human trafficking from the East Asian States found in over twenty (20) countries in regions across the globe, including the Americas, the Middle East, Europe, Central Asia and Africa ([41], p. 11).
The running of this global criminal enterprise is spearheaded by transnational criminal groups that cut across the continents of the world [1, 34]. These mafia groups combine drug trafficking, arms trafficking, money laundering and other forms of transnational crime with human trafficking—for both labour and sexual exploitation. According to Shelley, a combination of criminal gangs/organisations such as the Thai mafia, Indian criminal rings, Nigerian gang, Mexican group, Russian-speaking criminal ring, Albanian group and the Balkan criminal gang dominate the general human trafficking trade on a global scale [15, 34].
Regarding human trafficking for sexual exploitation, the combination of the Italian mafia families, Russian-speaking gang, Thai gang, Japanese Yakuza, the Triads, Jaotou, Jao Phro, Indian group, Sindikets (Syndicates in Malaysia), Fuk Ching in the United States dominate the trade [15, 34]. Other lesser mafia groups that dominate the sex trafficking market include the Dominican, Filipino and Turkish gang, amongst other trafficking entrepreneurs across the globe [15, 34, 42]. Most of these mafia organisations, especially those from the Asian axis have a turf, a hierarchical structure, restricted membership and often use violence to enforce compliance and exert authority [15, 34].
Contrastively, some other criminal networks of persons in human trade and other forms of transnational organised crime operate on an ad hoc basis, with no definite structure. It is instructive to state that most of these criminal groups have built strong empires of wealth and remained in the scene. Such vibrant structures were not necessarily fabricated due to the clandestine nature of the trade, but owing largely to the loopholes in most States structures and institutions (criminal justice), especially the police and border officials through corruption.
It is instructive to state at this juncture that the scale of research on human trafficking globally has been flooded with issues of sexual exploitation. Though a relatively appreciable volume also focus on the labour aspect, and few on organ harvesting, but the proportion of sexual domain is larger. The fact, however, is that the vast majority of modern day research findings have shown swelling incidences of trafficking of persons for labour exploitation in—agriculture, manufacturing industries, block factories, mining, fishing, domestic servants, carmel jockeys, pick-pockets, street vending, to mention a few [40].
The proportion of labour exploitation varies from State to State, from person to person, and often a function of the nature of task or work to be done (by trafficked victims). Labour exploitation often manifest itself in restriction of movement, seizure and confiscation of passport, daily verbal intimidation, cycles of abuses (rape, torture, beating, etc.), low wages, deduction or no pay at all, amongst others.
Contemporarily, the issue of human trafficking in Africa is taking a new dimension with the evolving menace of human trafficking into baby factories (or ‘baby farms’) for baby making coming to the centre stage. Onuoha [43] revealed this new wave of human trafficking in recent times. Though he argued that the incidence has been going-on for a while now in some parts of the world, but it is rising in a crescendo manner in Nigeria. However, it is very challenging to define the concept—‘baby factory’, ‘baby farming’ and ‘baby harvesting’ as they mean the same thing in this context, and as used by Onuoha.
Moreover, there is no legal definition for these terms since they are emerging concepts. However, according to Onuoha [43], baby factories ‘are locations where young ladies or girls, some teenagers or little above that, are harboured and deliberately encouraged or forced to become pregnant and subsequently give up their babies for sale’. Put differently, baby factory is an apartment or a form of accommodation in which teenagers and/or young ladies are kept (either voluntarily or by coercion), copulated, impregnated, and after delivery, their babies are taken away from them and sold to clients, agents or couples in need of babies. This could be done sometimes with or without the consent of the victims. This episode therefore brings to the fore a new concept in the human trafficking discourse: baby trafficking.
It is pertinent to state at this juncture that the problem of trafficking often do not begin with the traffickers, but with the circumstances that force victims to seek better living conditions in environments that render them vulnerable to exploitation [44]. Contrary to the popular embellished image of trafficked persons as either kidnapped, or coerced into leaving their homes, more often than not, the initial decision to migrate is often a conscious one [6]. Such decisions are further heightened by some of the factors that bedevilled Africa as earlier indicated.
Trafficking business thrives in Africa due to a range of precipitating factors can be broadly grouped into two—the ‘push’ and ‘pull’ factors [6, 9, 10]. The push and pull factors are two sides of the same coin—the causes of one can also be the consequence of another. While the push factors are those issues and circumstances that drive or force people into accepting demands that render them susceptible to trafficking, the pull factors encapsulate those that influence people into accepting dehumanising offers. The push factors that contribute to human trafficking in Africa include, but are not limited to poverty, political instability, greed, peer pressure, and lack of legitimate and sustainable employment opportunities and corruption [6, 45, 46, 47]. The pull factors include but are not limited to high demand for organs and body parts, the demand for cheap and low-skilled labour, the effect of globalisation, weak border control, economic disparities between developed and developing countries [19, 48, 49, 50, 51]. It is imperative to indicate that counter-trafficking measures in many African States have considerably been ineffective because most of the strategies have rested on the tripod stand of arrest, punishment and incarceration [17]. While these measures could thrive in addressing the proximate causes of the crime, the remote causes will require proactive measures that will facilitate the process of finding a durable solution its root causes.
This chapter began by underscoring the global resonance of human trafficking and its debilitating impacts on human lives, and international peace and security. It further explored the dynamics of human trafficking in Africa and the impacts of globalisation in engendering the rise and growth of trafficking businesses, in Africa as well as in other parts of the world. The factors and forces that created the artificial structures for trafficking to thrive in different parts of Africa were also identified and discussed. In addition, the root causes of human trafficking were highlighted. It also was indicated that except proactive and enduring measures are put in place at addressing those age-long root causes factors, State response to human trafficking in contemporary African States will be not be successful.
From the foregoing, to address the scourge of human trafficking in Africa, each State should first consider and find solution to the underlying or root causes of the crime. These factors are embedded in the countries’ socio-economic, political, and cultural milieus. If the various African countries address these factors, it will serve as trajectories to combating the phenomenon. Such task is however a collective responsibility of all relevant stakeholders, which include, the Government, Non-Governmental Organisations (NGOs), parents, civil societies, religious and educational institutions, and human rights groups, to mention a few.
General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed.
',metaTitle:"Horizon 2020 Compliance",metaDescription:"General requirements for Open Access to Horizon 2020 research project outputs are found within Guidelines on Open Access to Scientific Publication and Research Data in Horizon 2020. The guidelines, in their simplest form, state that if you are a Horizon 2020 recipient, you must ensure open access to your scientific publications by enabling them to be downloaded, printed and read online. Additionally, said publications must be peer reviewed. ",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"Publishing with IntechOpen means that your scientific publications already meet these basic requirements. It also means that through our utilization of open licensing, our publications are also able to be copied, shared, searched, linked, crawled, and mined for text and data, optimizing our authors' compliance as suggested by the European Commission.
\\n\\nMetadata for all publications is also automatically deposited in IntechOpen's OAI repository, making them available through the Open Access Infrastructure for Research in Europe's (OpenAIRE) search interface further establishing our compliance.
\\n\\nIn other words, publishing with IntechOpen guarantees compliance.
\\n\\nRead more about Open Access in Horizon 2020 here.
\\n\\nWhich scientific publication to choose?
\\n\\nWhen choosing a publication, Horizon 2020 grant recipients are encouraged to provide open access to various types of scientific publications including monographs, edited books and conference proceedings.
\\n\\nIntechOpen publishes all of the aforementioned formats in compliance with the requirements and criteria established by the European Commission for the Horizon 2020 Program.
\\n\\nAuthors requiring additional information are welcome to send their inquiries to funders@intechopen.com
\\n"}]'},components:[{type:"htmlEditorComponent",content:'Publishing with IntechOpen means that your scientific publications already meet these basic requirements. It also means that through our utilization of open licensing, our publications are also able to be copied, shared, searched, linked, crawled, and mined for text and data, optimizing our authors' compliance as suggested by the European Commission.
\n\nMetadata for all publications is also automatically deposited in IntechOpen's OAI repository, making them available through the Open Access Infrastructure for Research in Europe's (OpenAIRE) search interface further establishing our compliance.
\n\nIn other words, publishing with IntechOpen guarantees compliance.
\n\nRead more about Open Access in Horizon 2020 here.
\n\nWhich scientific publication to choose?
\n\nWhen choosing a publication, Horizon 2020 grant recipients are encouraged to provide open access to various types of scientific publications including monographs, edited books and conference proceedings.
\n\nIntechOpen publishes all of the aforementioned formats in compliance with the requirements and criteria established by the European Commission for the Horizon 2020 Program.
\n\nAuthors requiring additional information are welcome to send their inquiries to funders@intechopen.com
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[{id:"6700",title:"Dr.",name:"Abbass A.",middleName:null,surname:"Hashim",slug:"abbass-a.-hashim",fullName:"Abbass A. Hashim",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/6700/images/1864_n.jpg",biography:"Currently I am carrying out research in several areas of interest, mainly covering work on chemical and bio-sensors, semiconductor thin film device fabrication and characterisation.\nAt the moment I have very strong interest in radiation environmental pollution and bacteriology treatment. The teams of researchers are working very hard to bring novel results in this field. I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. I have served as the editor for many books, been a member of the editorial board in science journals, have published many papers and hold many patents.",institutionString:null,institution:{name:"Sheffield Hallam University",country:{name:"United Kingdom"}}},{id:"54525",title:"Prof.",name:"Abdul Latif",middleName:null,surname:"Ahmad",slug:"abdul-latif-ahmad",fullName:"Abdul Latif Ahmad",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"20567",title:"Prof.",name:"Ado",middleName:null,surname:"Jorio",slug:"ado-jorio",fullName:"Ado Jorio",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidade Federal de Minas Gerais",country:{name:"Brazil"}}},{id:"47940",title:"Dr.",name:"Alberto",middleName:null,surname:"Mantovani",slug:"alberto-mantovani",fullName:"Alberto Mantovani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"12392",title:"Mr.",name:"Alex",middleName:null,surname:"Lazinica",slug:"alex-lazinica",fullName:"Alex Lazinica",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/12392/images/7282_n.png",biography:"Alex Lazinica is the founder and CEO of IntechOpen. After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. He is an expert in structural, absorptive, catalytic and photocatalytic properties, in structural organization and dynamic features of ionic liquids, in magnetic interactions between paramagnetic centers. The author or co-author of 3 books, over 200 articles and reviews in scientific journals and books. He is an actual member of the International EPR/ESR Society, European Society on Quantum Solar Energy Conversion, Moscow House of Scientists, of the Board of Moscow Physical Society.",institutionString:null,institution:{name:"Semenov Institute of Chemical Physics",country:{name:"Russia"}}},{id:"62389",title:"PhD.",name:"Ali Demir",middleName:null,surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62389/images/3413_n.jpg",biography:"Dr. Ali Demir Sezer has a Ph.D. from Pharmaceutical Biotechnology at the Faculty of Pharmacy, University of Marmara (Turkey). He is the member of many Pharmaceutical Associations and acts as a reviewer of scientific journals and European projects under different research areas such as: drug delivery systems, nanotechnology and pharmaceutical biotechnology. Dr. Sezer is the author of many scientific publications in peer-reviewed journals and poster communications. Focus of his research activity is drug delivery, physico-chemical characterization and biological evaluation of biopolymers micro and nanoparticles as modified drug delivery system, and colloidal drug carriers (liposomes, nanoparticles etc.).",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"61051",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"100762",title:"Prof.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"St David's Medical Center",country:{name:"United States of America"}}},{id:"107416",title:"Dr.",name:"Andrea",middleName:null,surname:"Natale",slug:"andrea-natale",fullName:"Andrea Natale",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Texas Cardiac Arrhythmia",country:{name:"United States of America"}}},{id:"64434",title:"Dr.",name:"Angkoon",middleName:null,surname:"Phinyomark",slug:"angkoon-phinyomark",fullName:"Angkoon Phinyomark",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/64434/images/2619_n.jpg",biography:"My name is Angkoon Phinyomark. I received a B.Eng. degree in Computer Engineering with First Class Honors in 2008 from Prince of Songkla University, Songkhla, Thailand, where I received a Ph.D. degree in Electrical Engineering. My research interests are primarily in the area of biomedical signal processing and classification notably EMG (electromyography signal), EOG (electrooculography signal), and EEG (electroencephalography signal), image analysis notably breast cancer analysis and optical coherence tomography, and rehabilitation engineering. I became a student member of IEEE in 2008. During October 2011-March 2012, I had worked at School of Computer Science and Electronic Engineering, University of Essex, Colchester, Essex, United Kingdom. In addition, during a B.Eng. I had been a visiting research student at Faculty of Computer Science, University of Murcia, Murcia, Spain for three months.\n\nI have published over 40 papers during 5 years in refereed journals, books, and conference proceedings in the areas of electro-physiological signals processing and classification, notably EMG and EOG signals, fractal analysis, wavelet analysis, texture analysis, feature extraction and machine learning algorithms, and assistive and rehabilitative devices. I have several computer programming language certificates, i.e. Sun Certified Programmer for the Java 2 Platform 1.4 (SCJP), Microsoft Certified Professional Developer, Web Developer (MCPD), Microsoft Certified Technology Specialist, .NET Framework 2.0 Web (MCTS). I am a Reviewer for several refereed journals and international conferences, such as IEEE Transactions on Biomedical Engineering, IEEE Transactions on Industrial Electronics, Optic Letters, Measurement Science Review, and also a member of the International Advisory Committee for 2012 IEEE Business Engineering and Industrial Applications and 2012 IEEE Symposium on Business, Engineering and Industrial Applications.",institutionString:null,institution:{name:"Joseph Fourier University",country:{name:"France"}}},{id:"55578",title:"Dr.",name:"Antonio",middleName:null,surname:"Jurado-Navas",slug:"antonio-jurado-navas",fullName:"Antonio Jurado-Navas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/55578/images/4574_n.png",biography:"Antonio Jurado-Navas received the M.S. degree (2002) and the Ph.D. degree (2009) in Telecommunication Engineering, both from the University of Málaga (Spain). He first worked as a consultant at Vodafone-Spain. From 2004 to 2011, he was a Research Assistant with the Communications Engineering Department at the University of Málaga. In 2011, he became an Assistant Professor in the same department. From 2012 to 2015, he was with Ericsson Spain, where he was working on geo-location\ntools for third generation mobile networks. Since 2015, he is a Marie-Curie fellow at the Denmark Technical University. His current research interests include the areas of mobile communication systems and channel modeling in addition to atmospheric optical communications, adaptive optics and statistics",institutionString:null,institution:{name:"University of Malaga",country:{name:"Spain"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:5816},{group:"region",caption:"Middle and South America",value:2,count:5281},{group:"region",caption:"Africa",value:3,count:1754},{group:"region",caption:"Asia",value:4,count:10511},{group:"region",caption:"Australia and Oceania",value:5,count:906},{group:"region",caption:"Europe",value:6,count:15913}],offset:12,limit:12,total:119061},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{topicId:"1175"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:26},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:8},{group:"topic",caption:"Business, Management and Economics",value:7,count:3},{group:"topic",caption:"Chemistry",value:8,count:11},{group:"topic",caption:"Computer and Information Science",value:9,count:9},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:9},{group:"topic",caption:"Engineering",value:11,count:25},{group:"topic",caption:"Environmental Sciences",value:12,count:2},{group:"topic",caption:"Immunology and Microbiology",value:13,count:4},{group:"topic",caption:"Materials Science",value:14,count:7},{group:"topic",caption:"Mathematics",value:15,count:2},{group:"topic",caption:"Medicine",value:16,count:45},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:3},{group:"topic",caption:"Physics",value:20,count:4},{group:"topic",caption:"Psychology",value:21,count:4},{group:"topic",caption:"Robotics",value:22,count:1},{group:"topic",caption:"Social Sciences",value:23,count:3},{group:"topic",caption:"Technology",value:24,count:1},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:0},popularBooks:{featuredBooks:[{type:"book",id:"8472",title:"Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health",subtitle:null,isOpenForSubmission:!1,hash:"8855452919b8495810ef8e88641feb20",slug:"bioactive-compounds-in-nutraceutical-and-functional-food-for-good-human-health",bookSignature:"Kavita Sharma, Kanchan Mishra, Kula Kamal Senapati and Corina Danciu",coverURL:"https://cdn.intechopen.com/books/images_new/8472.jpg",editors:[{id:"197731",title:"Dr.",name:"Kavita",middleName:null,surname:"Sharma",slug:"kavita-sharma",fullName:"Kavita Sharma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9685",title:"Agroecosystems",subtitle:"Very Complex Environmental Systems",isOpenForSubmission:!1,hash:"c44f7b43a9f9610c243dc32300d37df6",slug:"agroecosystems-very-complex-environmental-systems",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/9685.jpg",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8564",title:"Cell Interaction",subtitle:"Molecular and Immunological Basis for Disease Management",isOpenForSubmission:!1,hash:"98d7f080d80524285f091e72a8e92a6d",slug:"cell-interaction-molecular-and-immunological-basis-for-disease-management",bookSignature:"Bhawana Singh",coverURL:"https://cdn.intechopen.com/books/images_new/8564.jpg",editors:[{id:"315192",title:"Dr.",name:"Bhawana",middleName:null,surname:"Singh",slug:"bhawana-singh",fullName:"Bhawana Singh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9629",title:"Electroencephalography",subtitle:"From Basic Research to Clinical Applications",isOpenForSubmission:!1,hash:"8147834b6c6deeeec40f407c71ad60b4",slug:"electroencephalography-from-basic-research-to-clinical-applications",bookSignature:"Hideki Nakano",coverURL:"https://cdn.intechopen.com/books/images_new/9629.jpg",editors:[{id:"196461",title:"Prof.",name:"Hideki",middleName:null,surname:"Nakano",slug:"hideki-nakano",fullName:"Hideki Nakano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8760",title:"Structure Topology and Symplectic Geometry",subtitle:null,isOpenForSubmission:!1,hash:"8974840985ec3652492c83e20233bf02",slug:"structure-topology-and-symplectic-geometry",bookSignature:"Kamal Shah and Min Lei",coverURL:"https://cdn.intechopen.com/books/images_new/8760.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9161",title:"Frailty in the Elderly",subtitle:"Understanding and Managing Complexity",isOpenForSubmission:!1,hash:"a4f0f2fade8fb8ba35c405f5ad31a823",slug:"frailty-in-the-elderly-understanding-and-managing-complexity",bookSignature:"Sara Palermo",coverURL:"https://cdn.intechopen.com/books/images_new/9161.jpg",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8445",title:"Dam Engineering",subtitle:"Recent Advances in Design and Analysis",isOpenForSubmission:!1,hash:"a7e4d2ecbc65d78fa7582e0d2e143906",slug:"dam-engineering-recent-advances-in-design-and-analysis",bookSignature:"Zhongzhi Fu and Erich Bauer",coverURL:"https://cdn.intechopen.com/books/images_new/8445.jpg",editors:[{id:"249577",title:"Dr.",name:"Zhongzhi",middleName:null,surname:"Fu",slug:"zhongzhi-fu",fullName:"Zhongzhi Fu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8937",title:"Soil Moisture Importance",subtitle:null,isOpenForSubmission:!1,hash:"3951728ace7f135451d66b72e9908b47",slug:"soil-moisture-importance",bookSignature:"Ram Swaroop Meena and Rahul Datta",coverURL:"https://cdn.intechopen.com/books/images_new/8937.jpg",editors:[{id:"313528",title:"Associate Prof.",name:"Ram Swaroop",middleName:null,surname:"Meena",slug:"ram-swaroop-meena",fullName:"Ram Swaroop Meena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7031",title:"Liver Pathology",subtitle:null,isOpenForSubmission:!1,hash:"631321b0565459ed0175917f1c8c727f",slug:"liver-pathology",bookSignature:"Vijay Gayam and Omer Engin",coverURL:"https://cdn.intechopen.com/books/images_new/7031.jpg",editors:[{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8158",title:"Veganism",subtitle:"a Fashion Trend or Food as a Medicine",isOpenForSubmission:!1,hash:"d8e51fc25a379e5b92a270addbb4351d",slug:"veganism-a-fashion-trend-or-food-as-a-medicine",bookSignature:"Miljana Z. Jovandaric",coverURL:"https://cdn.intechopen.com/books/images_new/8158.jpg",editors:[{id:"268043",title:"Dr.",name:"Miljana Z.",middleName:"Z",surname:"Jovandaric",slug:"miljana-z.-jovandaric",fullName:"Miljana Z. Jovandaric"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:5315},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"8472",title:"Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health",subtitle:null,isOpenForSubmission:!1,hash:"8855452919b8495810ef8e88641feb20",slug:"bioactive-compounds-in-nutraceutical-and-functional-food-for-good-human-health",bookSignature:"Kavita Sharma, Kanchan Mishra, Kula Kamal Senapati and Corina Danciu",coverURL:"https://cdn.intechopen.com/books/images_new/8472.jpg",editors:[{id:"197731",title:"Dr.",name:"Kavita",middleName:null,surname:"Sharma",slug:"kavita-sharma",fullName:"Kavita Sharma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9685",title:"Agroecosystems",subtitle:"Very Complex Environmental Systems",isOpenForSubmission:!1,hash:"c44f7b43a9f9610c243dc32300d37df6",slug:"agroecosystems-very-complex-environmental-systems",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/9685.jpg",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8564",title:"Cell Interaction",subtitle:"Molecular and Immunological Basis for Disease Management",isOpenForSubmission:!1,hash:"98d7f080d80524285f091e72a8e92a6d",slug:"cell-interaction-molecular-and-immunological-basis-for-disease-management",bookSignature:"Bhawana Singh",coverURL:"https://cdn.intechopen.com/books/images_new/8564.jpg",editors:[{id:"315192",title:"Dr.",name:"Bhawana",middleName:null,surname:"Singh",slug:"bhawana-singh",fullName:"Bhawana Singh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9629",title:"Electroencephalography",subtitle:"From Basic Research to Clinical Applications",isOpenForSubmission:!1,hash:"8147834b6c6deeeec40f407c71ad60b4",slug:"electroencephalography-from-basic-research-to-clinical-applications",bookSignature:"Hideki Nakano",coverURL:"https://cdn.intechopen.com/books/images_new/9629.jpg",editors:[{id:"196461",title:"Prof.",name:"Hideki",middleName:null,surname:"Nakano",slug:"hideki-nakano",fullName:"Hideki Nakano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8760",title:"Structure Topology and Symplectic Geometry",subtitle:null,isOpenForSubmission:!1,hash:"8974840985ec3652492c83e20233bf02",slug:"structure-topology-and-symplectic-geometry",bookSignature:"Kamal Shah and Min Lei",coverURL:"https://cdn.intechopen.com/books/images_new/8760.jpg",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9161",title:"Frailty in the Elderly",subtitle:"Understanding and Managing Complexity",isOpenForSubmission:!1,hash:"a4f0f2fade8fb8ba35c405f5ad31a823",slug:"frailty-in-the-elderly-understanding-and-managing-complexity",bookSignature:"Sara Palermo",coverURL:"https://cdn.intechopen.com/books/images_new/9161.jpg",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8445",title:"Dam Engineering",subtitle:"Recent Advances in Design and Analysis",isOpenForSubmission:!1,hash:"a7e4d2ecbc65d78fa7582e0d2e143906",slug:"dam-engineering-recent-advances-in-design-and-analysis",bookSignature:"Zhongzhi Fu and Erich Bauer",coverURL:"https://cdn.intechopen.com/books/images_new/8445.jpg",editors:[{id:"249577",title:"Dr.",name:"Zhongzhi",middleName:null,surname:"Fu",slug:"zhongzhi-fu",fullName:"Zhongzhi Fu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9385",title:"Renewable Energy",subtitle:"Technologies and Applications",isOpenForSubmission:!1,hash:"a6b446d19166f17f313008e6c056f3d8",slug:"renewable-energy-technologies-and-applications",bookSignature:"Tolga Taner, Archana Tiwari and Taha Selim Ustun",coverURL:"https://cdn.intechopen.com/books/images_new/9385.jpg",editors:[{id:"197240",title:"Associate Prof.",name:"Tolga",middleName:null,surname:"Taner",slug:"tolga-taner",fullName:"Tolga Taner"}],equalEditorOne:{id:"186791",title:"Dr.",name:"Archana",middleName:null,surname:"Tiwari",slug:"archana-tiwari",fullName:"Archana Tiwari",profilePictureURL:"https://mts.intechopen.com/storage/users/186791/images/system/186791.jpg",biography:"Dr. Archana Tiwari is Associate Professor at Amity University, India. Her research interests include renewable sources of energy from microalgae and further utilizing the residual biomass for the generation of value-added products, bioremediation through microalgae and microbial consortium, antioxidative enzymes and stress, and nutraceuticals from microalgae. She has been working on algal biotechnology for the last two decades. She has published her research in many international journals and has authored many books and chapters with renowned publishing houses. She has also delivered talks as an invited speaker at many national and international conferences. Dr. Tiwari is the recipient of several awards including Researcher of the Year and Distinguished Scientist.",institutionString:"Amity University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Amity University",institutionURL:null,country:{name:"India"}}},equalEditorTwo:{id:"197609",title:"Prof.",name:"Taha Selim",middleName:null,surname:"Ustun",slug:"taha-selim-ustun",fullName:"Taha Selim Ustun",profilePictureURL:"https://mts.intechopen.com/storage/users/197609/images/system/197609.jpeg",biography:"Dr. Taha Selim Ustun received a Ph.D. in Electrical Engineering from Victoria University, Melbourne, Australia. He is a researcher with the Fukushima Renewable Energy Institute, AIST (FREA), where he leads the Smart Grid Cybersecurity Laboratory. Prior to that, he was a faculty member with the School of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA. His current research interests include power systems protection, communication in power networks, distributed generation, microgrids, electric vehicle integration, and cybersecurity in smart grids. He serves on the editorial boards of IEEE Access, IEEE Transactions on Industrial Informatics, Energies, Electronics, Electricity, World Electric Vehicle and Information journals. Dr. Ustun is a member of the IEEE 2004 and 2800, IEC Renewable Energy Management WG 8, and IEC TC 57 WG17. He has been invited to run specialist courses in Africa, India, and China. He has delivered talks for the Qatar Foundation, the World Energy Council, the Waterloo Global Science Initiative, and the European Union Energy Initiative (EUEI). His research has attracted funding from prestigious programs in Japan, Australia, the European Union, and North America.",institutionString:"Fukushima Renewable Energy Institute, AIST (FREA)",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"National Institute of Advanced Industrial Science and Technology",institutionURL:null,country:{name:"Japan"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"8937",title:"Soil Moisture Importance",subtitle:null,isOpenForSubmission:!1,hash:"3951728ace7f135451d66b72e9908b47",slug:"soil-moisture-importance",bookSignature:"Ram Swaroop Meena and Rahul Datta",coverURL:"https://cdn.intechopen.com/books/images_new/8937.jpg",editors:[{id:"313528",title:"Associate Prof.",name:"Ram Swaroop",middleName:null,surname:"Meena",slug:"ram-swaroop-meena",fullName:"Ram Swaroop Meena"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"7031",title:"Liver Pathology",subtitle:null,isOpenForSubmission:!1,hash:"631321b0565459ed0175917f1c8c727f",slug:"liver-pathology",bookSignature:"Vijay Gayam and Omer Engin",coverURL:"https://cdn.intechopen.com/books/images_new/7031.jpg",editors:[{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"8472",title:"Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health",subtitle:null,isOpenForSubmission:!1,hash:"8855452919b8495810ef8e88641feb20",slug:"bioactive-compounds-in-nutraceutical-and-functional-food-for-good-human-health",bookSignature:"Kavita Sharma, Kanchan Mishra, Kula Kamal Senapati and Corina Danciu",coverURL:"https://cdn.intechopen.com/books/images_new/8472.jpg",editedByType:"Edited by",editors:[{id:"197731",title:"Dr.",name:"Kavita",middleName:null,surname:"Sharma",slug:"kavita-sharma",fullName:"Kavita Sharma"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8760",title:"Structure Topology and Symplectic Geometry",subtitle:null,isOpenForSubmission:!1,hash:"8974840985ec3652492c83e20233bf02",slug:"structure-topology-and-symplectic-geometry",bookSignature:"Kamal Shah and Min Lei",coverURL:"https://cdn.intechopen.com/books/images_new/8760.jpg",editedByType:"Edited by",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9536",title:"Education at the Intersection of Globalization and Technology",subtitle:null,isOpenForSubmission:!1,hash:"0cf6891060eb438d975d250e8b127ed6",slug:"education-at-the-intersection-of-globalization-and-technology",bookSignature:"Sharon Waller, Lee Waller, Vongai Mpofu and Mercy Kurebwa",coverURL:"https://cdn.intechopen.com/books/images_new/9536.jpg",editedByType:"Edited by",editors:[{id:"263302",title:"Dr.",name:"Sharon",middleName:null,surname:"Waller",slug:"sharon-waller",fullName:"Sharon Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8564",title:"Cell Interaction",subtitle:"Molecular and Immunological Basis for Disease Management",isOpenForSubmission:!1,hash:"98d7f080d80524285f091e72a8e92a6d",slug:"cell-interaction-molecular-and-immunological-basis-for-disease-management",bookSignature:"Bhawana Singh",coverURL:"https://cdn.intechopen.com/books/images_new/8564.jpg",editedByType:"Edited by",editors:[{id:"315192",title:"Dr.",name:"Bhawana",middleName:null,surname:"Singh",slug:"bhawana-singh",fullName:"Bhawana Singh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9629",title:"Electroencephalography",subtitle:"From Basic Research to Clinical Applications",isOpenForSubmission:!1,hash:"8147834b6c6deeeec40f407c71ad60b4",slug:"electroencephalography-from-basic-research-to-clinical-applications",bookSignature:"Hideki Nakano",coverURL:"https://cdn.intechopen.com/books/images_new/9629.jpg",editedByType:"Edited by",editors:[{id:"196461",title:"Prof.",name:"Hideki",middleName:null,surname:"Nakano",slug:"hideki-nakano",fullName:"Hideki Nakano"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9685",title:"Agroecosystems",subtitle:"Very Complex Environmental Systems",isOpenForSubmission:!1,hash:"c44f7b43a9f9610c243dc32300d37df6",slug:"agroecosystems-very-complex-environmental-systems",bookSignature:"Marcelo L. Larramendy and Sonia Soloneski",coverURL:"https://cdn.intechopen.com/books/images_new/9685.jpg",editedByType:"Edited by",editors:[{id:"14764",title:"Dr.",name:"Marcelo L.",middleName:null,surname:"Larramendy",slug:"marcelo-l.-larramendy",fullName:"Marcelo L. Larramendy"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9524",title:"Organ Donation and Transplantation",subtitle:null,isOpenForSubmission:!1,hash:"6ef47e03cd4e6476946fc28ca51de825",slug:"organ-donation-and-transplantation",bookSignature:"Vassil Mihaylov",coverURL:"https://cdn.intechopen.com/books/images_new/9524.jpg",editedByType:"Edited by",editors:[{id:"313113",title:"Associate Prof.",name:"Vassil",middleName:null,surname:"Mihaylov",slug:"vassil-mihaylov",fullName:"Vassil Mihaylov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9280",title:"Underwater Work",subtitle:null,isOpenForSubmission:!1,hash:"647b4270d937deae4a82f5702d1959ec",slug:"underwater-work",bookSignature:"Sérgio António Neves Lousada",coverURL:"https://cdn.intechopen.com/books/images_new/9280.jpg",editedByType:"Edited by",editors:[{id:"248645",title:"Dr.",name:"Sérgio António",middleName:null,surname:"Neves Lousada",slug:"sergio-antonio-neves-lousada",fullName:"Sérgio António Neves Lousada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9161",title:"Frailty in the Elderly",subtitle:"Understanding and Managing Complexity",isOpenForSubmission:!1,hash:"a4f0f2fade8fb8ba35c405f5ad31a823",slug:"frailty-in-the-elderly-understanding-and-managing-complexity",bookSignature:"Sara Palermo",coverURL:"https://cdn.intechopen.com/books/images_new/9161.jpg",editedByType:"Edited by",editors:[{id:"233998",title:"Ph.D.",name:"Sara",middleName:null,surname:"Palermo",slug:"sara-palermo",fullName:"Sara Palermo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8158",title:"Veganism",subtitle:"a Fashion Trend or Food as a Medicine",isOpenForSubmission:!1,hash:"d8e51fc25a379e5b92a270addbb4351d",slug:"veganism-a-fashion-trend-or-food-as-a-medicine",bookSignature:"Miljana Z. Jovandaric",coverURL:"https://cdn.intechopen.com/books/images_new/8158.jpg",editedByType:"Edited by",editors:[{id:"268043",title:"Dr.",name:"Miljana Z.",middleName:"Z",surname:"Jovandaric",slug:"miljana-z.-jovandaric",fullName:"Miljana Z. Jovandaric"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"1021",title:"Hepatology",slug:"gastroenterology-hepatology",parent:{title:"Gastroenterology",slug:"gastroenterology"},numberOfBooks:56,numberOfAuthorsAndEditors:1687,numberOfWosCitations:492,numberOfCrossrefCitations:385,numberOfDimensionsCitations:921,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicSlug:"gastroenterology-hepatology",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"7888",title:"Hepatitis A and Other Associated Hepatobiliary Diseases",subtitle:null,isOpenForSubmission:!1,hash:"e027bb08025546d9beb242d55e87c84c",slug:"hepatitis-a-and-other-associated-hepatobiliary-diseases",bookSignature:"Costin Teodor Streba, Cristin Constantin Vere, Ion Rogoveanu, Valeria Tripodi and Silvia Lucangioli",coverURL:"https://cdn.intechopen.com/books/images_new/7888.jpg",editedByType:"Edited by",editors:[{id:"55546",title:"Dr.",name:"Costin Teodor",middleName:"Teodor",surname:"Streba",slug:"costin-teodor-streba",fullName:"Costin Teodor Streba"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7887",title:"Hepatitis B and C",subtitle:null,isOpenForSubmission:!1,hash:"8dd6dab483cf505d83caddaeaf497f2c",slug:"hepatitis-b-and-c",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/7887.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8330",title:"Nonalcoholic Fatty Liver Disease",subtitle:"An Update",isOpenForSubmission:!1,hash:"d0f8ff2a0673b7be22f7e7c531a2e410",slug:"nonalcoholic-fatty-liver-disease-an-update",bookSignature:"Emad Hamdy Gad",coverURL:"https://cdn.intechopen.com/books/images_new/8330.jpg",editedByType:"Edited by",editors:[{id:"222727",title:"Associate Prof.",name:"Emad Hamdy",middleName:null,surname:"Gad",slug:"emad-hamdy-gad",fullName:"Emad Hamdy Gad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8838",title:"Liver Cirrhosis",subtitle:"Debates and Current Challenges",isOpenForSubmission:!1,hash:"17163eb18a082da0fe70ccc20b7fe69a",slug:"liver-cirrhosis-debates-and-current-challenges",bookSignature:"Georgios Tsoulfas",coverURL:"https://cdn.intechopen.com/books/images_new/8838.jpg",editedByType:"Edited by",editors:[{id:"57412",title:"Prof.",name:"Georgios",middleName:null,surname:"Tsoulfas",slug:"georgios-tsoulfas",fullName:"Georgios Tsoulfas"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6718",title:"Hepatitis C",subtitle:"From Infection to Cure",isOpenForSubmission:!1,hash:"7448805e61bfa52ce552c427ad6f16fc",slug:"hepatitis-c-from-infection-to-cure",bookSignature:"Imran Shahid",coverURL:"https://cdn.intechopen.com/books/images_new/6718.jpg",editedByType:"Edited by",editors:[{id:"188219",title:"Prof.",name:"Imran",middleName:null,surname:"Shahid",slug:"imran-shahid",fullName:"Imran Shahid"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6663",title:"Management of Chronic Liver Diseases",subtitle:"Recent Advances",isOpenForSubmission:!1,hash:"833ebcb9a2596f81deff0246ed7c9642",slug:"management-of-chronic-liver-diseases-recent-advances",bookSignature:"Xingshun Qi",coverURL:"https://cdn.intechopen.com/books/images_new/6663.jpg",editedByType:"Edited by",editors:[{id:"197501",title:"Dr.",name:"Xingshun",middleName:null,surname:"Qi",slug:"xingshun-qi",fullName:"Xingshun Qi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6440",title:"Liver Research and Clinical Management",subtitle:null,isOpenForSubmission:!1,hash:"e4bbd66ccead286ab737f23feb053cf8",slug:"liver-research-and-clinical-management",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6440.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6073",title:"Non-Alcoholic Fatty Liver Disease",subtitle:"Molecular Bases, Prevention and Treatment",isOpenForSubmission:!1,hash:"6141320881651ddc40a3f35893c209e7",slug:"non-alcoholic-fatty-liver-disease-molecular-bases-prevention-and-treatment",bookSignature:"Rodrigo Valenzuela",coverURL:"https://cdn.intechopen.com/books/images_new/6073.jpg",editedByType:"Edited by",editors:[{id:"72355",title:"Prof.",name:"Rodrigo",middleName:null,surname:"Valenzuela Baez",slug:"rodrigo-valenzuela-baez",fullName:"Rodrigo Valenzuela Baez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5931",title:"Stomach Disorders",subtitle:null,isOpenForSubmission:!1,hash:"489f823dd49e3fa397e477a8101ca4ff",slug:"stomach-disorders",bookSignature:"Jianyuan Chai",coverURL:"https://cdn.intechopen.com/books/images_new/5931.jpg",editedByType:"Edited by",editors:[{id:"28281",title:"Dr.",name:"Jianyuan",middleName:null,surname:"Chai",slug:"jianyuan-chai",fullName:"Jianyuan Chai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5714",title:"Esophageal Abnormalities",subtitle:null,isOpenForSubmission:!1,hash:"132a5e5097b78a76535fde4196596ac9",slug:"esophageal-abnormalities",bookSignature:"Jianyuan Chai",coverURL:"https://cdn.intechopen.com/books/images_new/5714.jpg",editedByType:"Edited by",editors:[{id:"28281",title:"Dr.",name:"Jianyuan",middleName:null,surname:"Chai",slug:"jianyuan-chai",fullName:"Jianyuan Chai"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6061",title:"Ascites",subtitle:"Physiopathology, Treatment, Complications and Prognosis",isOpenForSubmission:!1,hash:"ead9b3e5c36413f9ff2c3129fbc57574",slug:"ascites-physiopathology-treatment-complications-and-prognosis",bookSignature:"Luis Rodrigo",coverURL:"https://cdn.intechopen.com/books/images_new/6061.jpg",editedByType:"Edited by",editors:[{id:"73208",title:"Prof.",name:"Luis",middleName:null,surname:"Rodrigo",slug:"luis-rodrigo",fullName:"Luis Rodrigo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6014",title:"Update on Hepatitis C",subtitle:null,isOpenForSubmission:!1,hash:"b812442f63938a061f1c84b2338bb187",slug:"update-on-hepatitis-c",bookSignature:"Martina Smolic, Aleksandar Vcev and George Y. Wu",coverURL:"https://cdn.intechopen.com/books/images_new/6014.jpg",editedByType:"Edited by",editors:[{id:"172734",title:"Dr.",name:"Martina",middleName:null,surname:"Smolic",slug:"martina-smolic",fullName:"Martina Smolic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"3",chapterContentType:"chapter",authoredCaption:"Authored by"}}],booksByTopicTotal:56,mostCitedChapters:[{id:"46479",doi:"10.5772/57353",title:"Floating Drug Delivery Systems for Eradication of Helicobacter pylori in Treatment of Peptic Ulcer Disease",slug:"floating-drug-delivery-systems-for-eradication-of-helicobacter-pylori-in-treatment-of-peptic-ulcer-d",totalDownloads:2046,totalCrossrefCites:85,totalDimensionsCites:196,book:{slug:"trends-in-helicobacter-pylori-infection",title:"Trends in Helicobacter pylori Infection",fullTitle:"Trends in Helicobacter pylori Infection"},signatures:"Yousef Javadzadeh and Sanaz Hamedeyazdan",authors:[{id:"94276",title:"Prof.",name:"Yousef",middleName:null,surname:"Javadzadeh",slug:"yousef-javadzadeh",fullName:"Yousef Javadzadeh"},{id:"98229",title:"Dr.",name:"Sanaz",middleName:null,surname:"Hamedeyazdan",slug:"sanaz-hamedeyazdan",fullName:"Sanaz Hamedeyazdan"}]},{id:"22945",doi:"10.5772/17640",title:"Pathophysiology of Gastric Ulcer Development and Healing: Molecular Mechanisms and Novel Therapeutic Options",slug:"pathophysiology-of-gastric-ulcer-development-and-healing-molecular-mechanisms-and-novel-therapeutic-",totalDownloads:11792,totalCrossrefCites:8,totalDimensionsCites:21,book:{slug:"peptic-ulcer-disease",title:"Peptic Ulcer Disease",fullTitle:"Peptic Ulcer Disease"},signatures:"Matteo Fornai, Luca Antonioli, Rocchina Colucci, Marco Tuccori and Corrado Blandizzi",authors:[{id:"28973",title:"Prof.",name:"Corrado",middleName:null,surname:"Blandizzi",slug:"corrado-blandizzi",fullName:"Corrado Blandizzi"},{id:"44227",title:"Dr.",name:"Matteo",middleName:null,surname:"Fornai",slug:"matteo-fornai",fullName:"Matteo Fornai"},{id:"44229",title:"Dr.",name:"Luca",middleName:null,surname:"Antonioli",slug:"luca-antonioli",fullName:"Luca Antonioli"},{id:"44230",title:"Dr.",name:"Rocchina",middleName:null,surname:"Colucci",slug:"rocchina-colucci",fullName:"Rocchina Colucci"},{id:"44231",title:"Dr.",name:"Marco",middleName:null,surname:"Tuccori",slug:"marco-tuccori",fullName:"Marco Tuccori"}]},{id:"35446",doi:"10.5772/47946",title:"Delivery of Probiotic Microorganisms into Gastrointestinal Tract by Food Products",slug:"delivery-of-probiotic-microorganisms-into-gastrointestinal-tract-by-food-products",totalDownloads:5861,totalCrossrefCites:0,totalDimensionsCites:19,book:{slug:"new-advances-in-the-basic-and-clinical-gastroenterology",title:"New Advances in the Basic and Clinical Gastroenterology",fullTitle:"New Advances in the Basic and Clinical Gastroenterology"},signatures:"Amir Mohammad Mortazavian, Reza Mohammadi and Sara Sohrabvandi",authors:[{id:"97458",title:"Dr.",name:"Amir M.",middleName:null,surname:"Mortazavian",slug:"amir-m.-mortazavian",fullName:"Amir M. Mortazavian"},{id:"99974",title:"Dr.",name:"Sarah",middleName:null,surname:"Sohrabvandi",slug:"sarah-sohrabvandi",fullName:"Sarah Sohrabvandi"}]}],mostDownloadedChaptersLast30Days:[{id:"45493",title:"Biliary Dyspepsia: Functional Gallbladder and Sphincter of Oddi Disorders",slug:"biliary-dyspepsia-functional-gallbladder-and-sphincter-of-oddi-disorders",totalDownloads:5553,totalCrossrefCites:3,totalDimensionsCites:4,book:{slug:"dyspepsia-advances-in-understanding-and-management",title:"Dyspepsia",fullTitle:"Dyspepsia - Advances in Understanding and Management"},signatures:"Meena Mathivanan, Liisa Meddings and Eldon A. Shaffer",authors:[{id:"165693",title:"Dr.",name:"Eldon",middleName:null,surname:"Shaffer",slug:"eldon-shaffer",fullName:"Eldon Shaffer"}]},{id:"56262",title:"Anatomy of Esophagus",slug:"anatomy-of-esophagus",totalDownloads:2872,totalCrossrefCites:1,totalDimensionsCites:2,book:{slug:"esophageal-abnormalities",title:"Esophageal Abnormalities",fullTitle:"Esophageal Abnormalities"},signatures:"Murat Ferhat Ferhatoglu and Taner Kıvılcım",authors:[{id:"200126",title:"M.D.",name:"Murat Ferhat",middleName:null,surname:"Ferhatoglu",slug:"murat-ferhat-ferhatoglu",fullName:"Murat Ferhat Ferhatoglu"},{id:"206240",title:"Dr.",name:"Taner",middleName:null,surname:"Kivilcim",slug:"taner-kivilcim",fullName:"Taner Kivilcim"}]},{id:"56068",title:"Minimally Invasive Esophagectomy",slug:"minimally-invasive-esophagectomy",totalDownloads:924,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"esophageal-abnormalities",title:"Esophageal Abnormalities",fullTitle:"Esophageal Abnormalities"},signatures:"Rafael Cholvi Calduch, Isabel Mora Oliver, Fernando Lopez Mozos\nand Roberto Martí Obiol",authors:[{id:"203292",title:"Ph.D.",name:"Fernando",middleName:null,surname:"Lopez",slug:"fernando-lopez",fullName:"Fernando Lopez"},{id:"203687",title:"Dr.",name:"Roberto",middleName:null,surname:"Martí",slug:"roberto-marti",fullName:"Roberto Martí"},{id:"204943",title:"Dr.",name:"Rafael",middleName:null,surname:"Cholvi",slug:"rafael-cholvi",fullName:"Rafael Cholvi"},{id:"204944",title:"Dr.",name:"Isabel",middleName:null,surname:"Mora",slug:"isabel-mora",fullName:"Isabel Mora"}]},{id:"21425",title:"Histopathological Diagnosis of Non-Alcoholic and Alcoholic Fatty Liver Disease",slug:"histopathological-diagnosis-of-non-alcoholic-and-alcoholic-fatty-liver-disease",totalDownloads:2948,totalCrossrefCites:2,totalDimensionsCites:2,book:{slug:"liver-biopsy-in-modern-medicine",title:"Liver Biopsy in Modern Medicine",fullTitle:"Liver Biopsy in Modern Medicine"},signatures:"Andrea Tannapfel and Berenike Flott-Rahmel",authors:[{id:"34863",title:"Dr.",name:"Andrea",middleName:null,surname:"Tannapfel",slug:"andrea-tannapfel",fullName:"Andrea Tannapfel"},{id:"53108",title:"Prof.",name:"Berenike",middleName:null,surname:"Flott-Rahmel",slug:"berenike-flott-rahmel",fullName:"Berenike Flott-Rahmel"}]},{id:"55879",title:"Portal Hypertensive Gastropathy (PHG)",slug:"portal-hypertensive-gastropathy-phg-",totalDownloads:1115,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"stomach-disorders",title:"Stomach Disorders",fullTitle:"Stomach Disorders"},signatures:"Samia Ali Gamie",authors:[{id:"204157",title:"Prof.",name:"Samia",middleName:null,surname:"Ali Abdo Gamie",slug:"samia-ali-abdo-gamie",fullName:"Samia Ali Abdo Gamie"}]},{id:"57005",title:"Health-Related Quality of Life in Antiviral-Treated Chronic Hepatitis C Patients",slug:"health-related-quality-of-life-in-antiviral-treated-chronic-hepatitis-c-patients",totalDownloads:988,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"update-on-hepatitis-c",title:"Update on Hepatitis C",fullTitle:"Update on Hepatitis C"},signatures:"Aleksandar Včev, Jelena Jakab, Lucija Kuna and Martina Smolić",authors:[{id:"154595",title:"Prof.",name:"Aleksandar",middleName:null,surname:"Vcev",slug:"aleksandar-vcev",fullName:"Aleksandar Vcev"},{id:"172734",title:"Dr.",name:"Martina",middleName:null,surname:"Smolic",slug:"martina-smolic",fullName:"Martina Smolic"},{id:"204953",title:"Ms.",name:"Lucija",middleName:null,surname:"Kuna",slug:"lucija-kuna",fullName:"Lucija Kuna"},{id:"205159",title:"Dr.",name:"Jelena",middleName:null,surname:"Jakab",slug:"jelena-jakab",fullName:"Jelena Jakab"}]},{id:"55818",title:"Tissue Engineering of Esophagus",slug:"tissue-engineering-of-esophagus",totalDownloads:998,totalCrossrefCites:0,totalDimensionsCites:0,book:{slug:"esophageal-abnormalities",title:"Esophageal Abnormalities",fullTitle:"Esophageal Abnormalities"},signatures:"Yabin Zhu, Mi Zhou and Ruixia Hou",authors:[{id:"40618",title:"Prof.",name:"Yabin",middleName:null,surname:"Zhu",slug:"yabin-zhu",fullName:"Yabin Zhu"}]},{id:"55045",title:"Hemodynamic Optimization Strategies in Anesthesia Care for Liver Transplantation",slug:"hemodynamic-optimization-strategies-in-anesthesia-care-for-liver-transplantation",totalDownloads:1298,totalCrossrefCites:0,totalDimensionsCites:1,book:{slug:"liver-cirrhosis-update-and-current-challenges",title:"Liver Cirrhosis",fullTitle:"Liver Cirrhosis - Update and Current Challenges"},signatures:"Alexander A. Vitin, Dana Tomescu and Leonard Azamfirei",authors:[{id:"201176",title:"Associate Prof.",name:"Alexander",middleName:null,surname:"Vitin",slug:"alexander-vitin",fullName:"Alexander Vitin"},{id:"202442",title:"Dr.",name:"Dana",middleName:null,surname:"Tomescu",slug:"dana-tomescu",fullName:"Dana Tomescu"},{id:"202600",title:"Prof.",name:"Leonard",middleName:null,surname:"Azamfirei",slug:"leonard-azamfirei",fullName:"Leonard Azamfirei"}]},{id:"56177",title:"Nutritional Management of Esophageal Cancer Patients",slug:"nutritional-management-of-esophageal-cancer-patients",totalDownloads:1240,totalCrossrefCites:1,totalDimensionsCites:1,book:{slug:"esophageal-abnormalities",title:"Esophageal Abnormalities",fullTitle:"Esophageal Abnormalities"},signatures:"Dimitrios Schizas, Irene Lidoriki, Demetrios Moris and Theodore\nLiakakos",authors:[{id:"203349",title:"Dr.",name:"Dimitrios",middleName:null,surname:"Schizas",slug:"dimitrios-schizas",fullName:"Dimitrios Schizas"},{id:"204000",title:"MSc.",name:"Irene",middleName:null,surname:"Lidoriki",slug:"irene-lidoriki",fullName:"Irene Lidoriki"},{id:"204001",title:"Dr.",name:"Demetrios",middleName:null,surname:"Moris",slug:"demetrios-moris",fullName:"Demetrios Moris"},{id:"204002",title:"Prof.",name:"Theodore",middleName:null,surname:"Liakakos",slug:"theodore-liakakos",fullName:"Theodore Liakakos"}]},{id:"46479",title:"Floating Drug Delivery Systems for Eradication of Helicobacter pylori in Treatment of Peptic Ulcer Disease",slug:"floating-drug-delivery-systems-for-eradication-of-helicobacter-pylori-in-treatment-of-peptic-ulcer-d",totalDownloads:2046,totalCrossrefCites:86,totalDimensionsCites:196,book:{slug:"trends-in-helicobacter-pylori-infection",title:"Trends in Helicobacter pylori Infection",fullTitle:"Trends in Helicobacter pylori Infection"},signatures:"Yousef Javadzadeh and Sanaz Hamedeyazdan",authors:[{id:"94276",title:"Prof.",name:"Yousef",middleName:null,surname:"Javadzadeh",slug:"yousef-javadzadeh",fullName:"Yousef Javadzadeh"},{id:"98229",title:"Dr.",name:"Sanaz",middleName:null,surname:"Hamedeyazdan",slug:"sanaz-hamedeyazdan",fullName:"Sanaz Hamedeyazdan"}]}],onlineFirstChaptersFilter:{topicSlug:"gastroenterology-hepatology",limit:3,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[{type:"book",id:"10176",title:"Microgrids and Local Energy Systems",subtitle:null,isOpenForSubmission:!0,hash:"c32b4a5351a88f263074b0d0ca813a9c",slug:null,bookSignature:"Prof. Nick Jenkins",coverURL:"https://cdn.intechopen.com/books/images_new/10176.jpg",editedByType:null,editors:[{id:"55219",title:"Prof.",name:"Nick",middleName:null,surname:"Jenkins",slug:"nick-jenkins",fullName:"Nick Jenkins"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:8,limit:8,total:1},route:{name:"profile.detail",path:"/profiles/160415/giovanni-scandale",hash:"",query:{},params:{id:"160415",slug:"giovanni-scandale"},fullPath:"/profiles/160415/giovanni-scandale",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()