RII of risk categories.
\r\n\tThe purpose of this book is to provide the readers with an understanding of the characteristics of the crisis itself, recognize the wide range and multi-layer of the crisis from a real situation, give ideas on how to minimize the damage, and find ways to increase resilience in the future. To adapt to the rapidly and diversely changing world, the necessary experience and appropriate management for all kinds of crisis issues will be discussed as well. At the same time, it is intended to suggest elements such as verified scientific and empirical knowledge and applicable technologies; more effective risk management operation; modeling of the risks, manuals, management plans, and strategies.
\r\n\t
Ventral hernias are a classification of hernias affecting the abdominal wall. Included in this definition are epigastric, umbilical, Spigelian, and incisional hernias [1]. Repair of these hernias remains one of the most commonly performed procedures with more than 350,000 performed per year in the United States (SAGES) [2]. In addition to the cosmetic detriment, these hernias also pose a risk for bowel ischemia and strangulation, which can result in grave consequences.
Early descriptions of ventral hernias were evident in tomb paintings from ancient Egypt. Servants and workmen were depicted with abdominal protrusions [3]. Historian George Moritz Ebers (1837–1898) obtained an ancient papyrus, now referred to as the “Ebers papyrus.” In that document, additional descriptions of hernias were given. In ancient Greece, Hippocrates (460–375 BC) also described inguinal hernias [4]. While attempts to operate on inguinal hernias have been well described through the Middle Ages to the nineteenth century, reports on ventral hernia repairs during this era were limited.
The first reports of surgical hernia repair were published in the late nineteenth and early twentieth centuries, mostly describing umbilical hernia repair. At the time, surgical repair of hernias was considered “radical,” with most people preferring reduction with a pad or suspension of incarcerated hernias [5]. Dr. Lucas‐Championniere was one of the first surgeons to describe the principle of excising the hernia sac and closure of the neck [6]. The next evolution in hernia repair came in circa 1901, when William Mayo described primary repair using overlapping layers of fascia, or “pants over vest” technique. He “advocated the overlapping of the aponeurotic structures which were already at hand, securing a wide area of adhesions in place of edge to edge union” [7]. Incisional hernias were also recognized in this era. Kenelm Winslow described the experience of surgeons at the time emphasizing prevention of these hernias by closing incisions in layers. He also noted that although the repair described by Mayo had become popular, recurrence was a persistent problem, especially with large hernias [8]. In the early 1960s, knitted polypropylene mesh was introduced, which revolutionized repair, allowing for decreased recurrence rates. This repair allowed for additional variations in repair based on the placement of the mesh including extraperitoneal versus intraperitoneal placement [9, 10].
The evolution of hernia repair continued with adaptation of minimally invasive surgery. The first laparoscopic ventral hernia repair was described in 1993 by LeBlanc and Booth [11]. Using 4 to 5 trocars, they repaired hernias in five patients using polytetrafluoroethylene (PTFE) mesh [8]. Laparascopic ventral hernia repair has become increasingly utilized in select cases, allowing for increased mesh overlap of defects and reduced postoperative complications compared to open repair. A limitation to laparoscopic ventral hernia repair, however, is that it remains a technically challenging procedure with a steep learning curve.
Robotic surgery allows for a way to alleviate the challenges presented by laparoscopic surgery. In 2000, the FDA approved the first robotic surgery system. The first robotic assisted ventral hernia repair was first described by Ballantyne et al. in 2003 [12] during which a PTFE mesh was placed and secured with a combination of sutures and tacks. Currently, the use of robotic ventral hernia repair is growing worldwide as a robotic platform allows for a more straightforward primary closure of the defect with the aid of wristed instruments. As the current body of literature is still evolving, the evaluation of its role as it relates to laparoscopic or open ventral hernia repairs is yet to be determined.
Incisional hernia
Umbilical hernia
Spigelian hernia
Epigastric hernia
Incarcerated hernia
Inability to tolerate general anesthesia
Dense adhesions
Bowel necrosis
Conversion to conventional laparoscopy may be necessary if there is malfunction of the robotic components.
The surgeon should be prepared to convert to an open procedure in the event of significant hemorrhage, bowel injury, or limited accessibility due to diffuse adhesive disease.
Materials
da Vinci robotic platform
Endo shears
Blunt grasper
Hook cautery
Available energy source
Mesh
(optional) Sterile ruler; ruler provided with marking pen can be used
(optional) Air seal
Operating room setup.
After administration of general anesthesia, the patient is placed in the supine position with arms tucked. The operating table can be rotated to accommodate positioning of the robotic tower (Figures 1 and 2). Three ports are placed on the contralateral (or any side if hernia is midline) side to accommodate the instrument arms and camera. The ports are 5 or 8 mm wide and are placed 8 to 10 cm apart to avoid instrument collision. If using the da Vinci Si system, it may help to place bariatric trocar near the anterior superior iliac spine to avoid collision with the hip during dissection. Utilizing bariatric long trocar will move the instruments away from the hip, thus allowing for a free range of motion with the instruments. In our practice, we sometimes also include an accessory port on the opposite side to assist with instrument exchanges such as sutures and mesh introduction.
Docked robot with port placement.
Dissection of hernia sac with Endoshears.
Adhesions are taken down using a combination of blunt dissection using a blunt grasper and Endoshears. The Endoshears have a versatile use, and when connected to an energy source, they can function in place of a hook cautery (using either with closed tips or with one jaw), control bleeding, or aid in blunt dissection (Figure 3). In our practice, we measure the defect by inserting a sterile ruler into the abdominal cavity. After insufflation is released to 5 to 8 mmHg, the dimensions of the defect are recorded to allow for adequate estimation of the defect.
A 4‐ to 5‐cm circumferential overlap is desirable for ventral hernia repairs and accommodates for related shrinkage. Products available include polypropylene and polyester mesh. At our institution, we most commonly use the polypropylene mesh. The mesh is rolled extracorporeally and secured with a single stay suture. It is then introduced into the cavity using an accessory 12‐mm port. The mesh repair can then proceed using one of the following methods: intraperitoneal onlay mesh (IPOM), transabdominal preperitoneal (TAPP), transversus abdominis release (TAR), and retromuscular repair.
Repairs using intraperitoneal onlay mesh originated with inguinal hernia repair and soon found a role in ventral hernia repair [13–15]. The repair is completed by positioning the mesh over the defect with 4 to 5 cm overlap. The mesh can be secured using permanent or absorbable tackers. This can be done using the standard laparoscopic technique. An advantage of the robotic platform is that with the degrees of freedom, the mesh can also be sewn in. In this method, two to four tacks can be used to position the mesh if needed. The mesh is secured with a running absorbable suture around the border.
Early hypotheses associated transfascial sutures and tacks with increased pain; however, there has been no significant difference in retrospective reviews. Transfascial sutures and tacking have demonstrated similar pain profiles in available series that analyzed postoperative pain, opiate use, and telephone interview follow‐up (mean follow‐up 30 months). Transfascial sutures were, however, associated with increased infection rate [16–18]. To date, there are no comparisons of prospective randomized controlled studies on running suture versus transfascial sutures or tacking.
Given the concern for adhesions to mesh, potential for mesh migration, and other complications associated with intraperitoneal onlay mesh, there has been an increasing interest in more physiologic repairs. Preperitoneal repair for ventral hernia was first described in 2002, after it had already gained popularity in the repair of inguinal hernias [19]. In this technique, a peritoneal flap is created, and after the mesh is secured with tacks, the peritoneum is reconstructed with intracorporeal sutures. When compared to laparoscopic IPOM, there were no major differences in outcomes [20–22]. Despite the benefits of laparoscopic preperitoneal repair, the literature reflects a select few limited case series and case reports using this technique [23]. This may reflect the technical difficulty of laparoscopy in creating and closing the peritoneal flap. The articulating instruments and degree of freedom offered by robotic surgery can compensate for the difficult maneuvers required to perform a TAPP ventral hernia repair. The experience with robotic TAPP is evolving and has been demonstrated as a safe and feasible procedure in small retrospective case series [24]. The procedure starts with adhesiolysis and careful delineation of the hernia sac. Upon reduction of hernia sac, peritoneal flap creation starts. We typically start the dissection on the ipsilateral side of the port midway on the falciform ligament. By gently pulling down on the falciform ligament, a small area of peritoneum is opened and the dissection is initially carried out in superior to inferior dissection. Once the peritoneum is opened, the peritoneal flap creation is carried out laterally to accommodate the mesh with a 4‐ to 5‐cm overlap. If enough peritoneum is dissected off of the posterior sheath, the peritoneum can be flexible enough to cover the mesh on the ipsilateral side to equally cover the mesh (Figure 4A). The flap can be created either through single docking with unilateral ports on one side or via double docking with ports on both sides of the abdomen. In our experience, TAPP repair for primary hernias such as epigastric and umbilical hernias can be accomplished using single docking; however, for the incisional hernias, it is preferable to employ double‐docking technique by creating a flap starting in the midline. Upon completion of flap creation, the hernia defect can be primarily approximated using locking sutures. The mesh can then be placed in the preperitoneal space and secured to the posterior sheath with either sutures or absorbable tackers (Figure 4B). Upon completing mesh fixation, the peritoneal flap created can then be used to cover the mesh providing space for the mesh to integrate with posterior sheath and avoiding contact with intraperitoneal contents (Figure 4C) [30].
(Top) Creation of preperitoneal flap. (A) Lateral edge of peritoneal dissection. (B) Hernia defect and (C) lateral border of dissection. (Middle) Placement of mesh in preperitoneal space. (Bottom) Closure of peritoneum over the hernia defect.
Although tension‐free repairs using mesh have been successful, the patient’s posterior rectus provides a natural and less costly abdominal wall barrier. In this technique, after reduction of the hernia, the peritoneum and posterior rectus sheath are dissected from the rectus muscle. The dissection is then extended laterally and the transversus abdominis muscle aponeurosis is incised, producing component separation which allows for primary repair of the hernia defect. The primary repair can be completed using locking sutures, such as the STRATAFIX, which has been approved by the FDA for fascial closure [25].
Component separation, a therapy for extensive abdominal wall defects, can also be achieved using minimally invasive techniques. Open component separation is still limited by recurrence and associated wound complications. Carbonell et al. reported release of the posterior rectus sheath in the retromuscular space and referred to it as posterior component separation technique (PCST) [26]. Posterior component separation was also adapted to minimally invasive techniques using the robot. When compared to laparoscopic ventral hernia repair in an analysis of Americas Hernia Society Quality Collaborative database, RRVHR was not significantly different in terms of direct hospital costs, narcotic requirements but was associated with increased incidence of seroma [27].
After the hernia is identified and reduced, edges of the hernia sac are delineated and edges are opened with electrocautery. Once the edges are opened, posterior sheath is separated from the rectus and the anterior sheath, and the dissection is carried out laterally until neurovascular bundles are found. Care must be taken to avoid disrupting the linea alba as the dissection is carried out. This should classically be done with ports on the bilateral flank. The initial dissection can start on one side, and once posterior sheath is separated on one edge of the hernia sac, additional ports are placed on the contralateral side. The above step is repeated to separate the posterior sheath from the rectus (Figure 5). Upon completely entering the retromuscular space, the hernia defect can be approximated using locking sutures and mesh reinforcement can be performed below the primary repair of the defect. The posterior sheath, which was separated, is then closed below the mesh using sutures to fully place the mesh in the retromuscular space. The peritoneum and posterior rectus fascia are both separated from the posterior rectus muscle. A 4 to 5 cm perimeter is dissected. After repair of the primary defect, the polypropylene mesh is then placed inside the cavity and secured using a circumferential locking suture. The peritoneum and posterior fascia are then reapproximated using running locking suture.
Dissection of the peritoneum and posterior rectus sheath to create a retromuscular space.
When securing the mesh during IPOM, avoid large gaps, which can allow bowel to become caught in the mesh
To obtain an accurate measurement, we can use a sterile ruler with reduction in pneumoperitoneum (Figure 6)
If complete closure of the peritoneum cannot be achieved, we can suture borders of peritoneum to preperitoneal mesh (Figure 7).
Intracorporeal measurement of the defect.
Partial peritoneal coverage of preperitoneal mesh.
The cost benefit to laparoscopic ventral hernia repairs mirrors the clinical benefits of this approach. With decreased operative times and complications, accounting for readmissions and recurrences, laparoscopic ventral hernia repair was shown to be cost effective, including 1‐year follow‐up in analysis of both a statewide database and the National Inpatient Sample [28]. A concern of the use of robotic surgery is the cost of the technology. Consensus on the impact of cost has been a topic of controversy. As previously noted, laparoscopic and robotic retromuscular repairs do not significantly differ in terms of direct hospital costs in an analysis of a large multicenter database [27]. Differences in costs are multifactorial, and costs can be distributed in centers where multiple services are utilizing the robot. Kudsi et al., after finding improvement in operative times, suggested that this may also be an area of cost savings [29].
Minimally invasive surgery in obese patients can be challenging. Body habitus and extensive subcutaneous tissue can hinder efforts to achieve pneumoperitoneum and maneuver laparoscopic instruments. Moreover, this population is at higher risk of developing recurrent incisional hernias and higher risks of complications following repair. Patients with a body mass index (BMI) ≥ 30 kg/m2 have demonstrated poorer outcomes following ventral hernia repair, have higher rates of recurrence, more complications, and longer hospital stays [30]. The benefits of performing minimally invasive surgery in obese patients can compensate for the associated difficulties. Minimally invasive ventral hernia repair is associated with lower complication and recurrence rates. In a retrospective review of 163 obese patients (BMI ≥ 30 kg/m2), Novitsky et al. found significantly lower rates of both complications and recurrences with laparoscopic PTFE mesh repair compared to open repair. The improved outcomes were associated with safe entry into abdomen via left upper quadrant, meticulous adhesiolysis, adequate mesh overlap (4 to 5 cm) and use of 4 to 6 equally spaced nonabsorbable sutures to secure the mesh [31]. Several other studies have reached similar conclusions, including more recent retrospective review in 2016 by Froylich et al., who found similar outcomes when comparing open to minimally invasive ventral hernia repair [32].
Robotic hernia repair provides several advantages to laparoscopy, but the literature is sparse for its use specifically in the obese patient population. In a small retrospective review comparing robotic‐assisted to laparoscopic repair, where the mean BMI was 31.5 kg/m2, the outcome showed a comparable success rate for robotic repair [33].
In our practice, we do not include pediatric patients; however, minimally invasive ventral hernia repair has been practiced in this population. The first series of minimally invasive ventral hernia repair in children was reported in 2006 using 3‐mm ports and standard laparoscopic equipment with a mean age of 2 years in those with epigastric hernias and 4.2 years in patients with umbilical hernias, demonstrating that the procedure was safe and feasible [34]. Robotic ventral hernia repair is yet to be reported in this population; however, the scope of robotic surgery has expanded to include repair of congenital diaphragmatic hernias, cholecystectomy, and inguinal hernias.
As robotic surgery becomes increasingly integrated into various practices, including cardiothoracic surgery, oncologic surgery as well as urology and gynecology, it is also becoming important for trainees to become familiar with this technology. Simulation software included with the system allows trainees to develop skills. During live surgery, the ability to alternate between consoles provides a similar learning environment to standard open and laparoscopic surgery without affecting patient safety. A consensus on general surgery training and robotic training has not been described; however, in the field of urology, the importance of robotic training has been well recognized as a vital tool for trainees to grasp projecting that it will become basic skill in the future [35, 36]. In a recent survey addressing attitudes of general surgery attendings and residents, 73% of residents completed robotic simulator training, with 20% having experience as the primary console operator. One hundred percent of attending surgeons surveyed believed that robotic surgery training should be included in general surgery training programs [37].
The evolution of surgery for ventral hernias has followed developments in inguinal hernia repair. From trusses and external devices came open repair followed by minimally invasive techniques. The difficulties encountered with the limits of laparoscopic repair have been alleviated by the versatility offered by robotic surgery which includes enhanced dexterity, visualization, and ergonomics. Options for minimally invasive techniques include a wide variety of techniques reflecting the complexity of abdominal wall components and include intraperitoneal onlay mesh, transabdominal preperitoneal repair, transverse abdominis release, and retromuscular repairs. While the safety and efficacy of all of these modalities has been well validated, the type of repair should be patient centered.
While cost remains a concern in robotic ventral hernia repair, this is a topic of controversy. Assessing cost is a complex moving target and is sensitive to metrics such as operative times, utilization, and maintenance. Analysis of total robotic utilization across all specialties in an institution may be warranted to capture the true effect on healthcare costs.
As the use of robotic surgery has spread to include ventral hernia repair, it is likely that this can prove to be true for a broad range of procedures, making the techniques used in ventral hernia repair useful for building a basic skillset. For our current surgical trainees, this is especially true, and it is yet to be determined how this will shape general surgery curricula.
Risk is the chance of something happening that has an impact upon objectives. It is measured in terms of consequences and likelihood. Probability, likelihood, and chance are used synonymously, as also are consequences and impact. Everyone struggles to understand and deal with many risk situations—from a domestic to corporate level, personal to national level, activity to project level. Management of projects can be improved by raising awareness about risks, and then implementing formal processes to deal with them. Construction projects are fundamentally susceptible to risks. Projects can be successful if managers plan for risks—planning, identifying, analyzing, and providing response for undesirable events that can occur. Choudhry and Iqbal [1] reveal that risk management is a new area in the construction sector and is attaining importance in the construction industry. The application of systematic risk management system is necessary for managing project risks [1]. Risk management can be applied successfully by identifying the risk sources connected with activities of the project. These risks are quantified in terms of likelihood and impact. Akintoye and Macleod [2] revealed that risk affects the performance, quality, budget and productivity of projects in construction. The strategy is to decrease the probability and impact of a risk [3]. Dikemen et al. [4] defined risk management as a systematic procedure of controlling risk. Choudhry and Iqbal [1] defined risk management as a stepwise process comprising on identification, analysis and risk response. Other researchers defined risk analysis as the procedure of evaluating identified risk and opportunities for their magnitude to proceed for a matching response in the light of limited funds.
Projects related to construction are complicated because they contain a range of human and non-human factors. These projects are started in complicated and vibrant environment resulting in high uncertainty, which are multifaceted by challenging time restraints [5]. Identifying and analyzing prospective risks can increase effective completion of the project. Risk management offers an opportunity for project stakeholders to review the project through a collective dialog, to recognize better and evaluate the prospective problems and then formulate a suitable response [6].
Various methods and models are developed by investigators to analyze risks. A decision support framework called as Advanced Programmatic Risk Analysis and Management Model (APRAM) is useful for risk management [7, 8]. Nasir et al. [9] devised a schedule risk model called as Evaluating Risk in Construction—Schedule Model (ERIC-S) that estimates the pessimistic and optimistic duration of activities. Ökmen and Öztas [10] proposed the Construction Schedule Risk Analysis Model (CSRAM) that evaluates schedule networks under uncertainty when duration of activities and risk factors are correlated. All these models evaluate either the time schedule risks, cost risks or both.
Risk management is vital in construction to minimize losses and improving profitability [2]. Williams et al. [11] proposed a method of risk management. Complicated projects, such as metro rail contains risks from the feasibility stage, construction to commissioning. Risks in heavy construction have a direct impact on the cost, schedule and performance. Reilly and Brown [12] reveal that infrastructure underground metro is inherently complex project having uncertain and variable ground situations. For these kinds of projects, it is vital to identify risk as early as possible in the project [12]. A risk management plan, if developed would ensure smooth attainment of project goals within given time, cost and quality. Moreover, it can safeguard better safety throughout the construction process and operative stage of the project.
Uncertainties in on-site and off-site project activities often result in the risk of delays and schedule overruns in construction projects. A risk analysis approach that assesses the integrating impact of uncertainties [13] show that growth in project size and work quantities intensifies pair and group interconnection of tasks within and between groups of on-site and off-site activities, resulting in lengthened completion times and deviations from project plans. Vu et al. [14] revealed that prolonged schedule delays have an extremely detrimental impact on a project’s efficiency, cost and investment reputation.
Experienced experts are involved in analysis of risks qualitatively. Analyst needs to systematic and experienced to identify effectively internal or external risks. Mulholland and Christian [5] reveal that the decision maker makes the best use of experience and information in identifying risks. Akintoye and Macleod [2] reveal that an individual’s attitudes, beliefs, and judgment can influence risk perception. Many professionals find that risk identification and risk analysis require involvement of experts and advanced techniques [1].
Choudhry and Iqbal [1] reveal that formal risk management is a rare in the construction industry of Pakistan. The authors explained that contractors are not practicing risk management formally. Major barriers to risk management are non-adaptation of formal risk management system [1]. Projects in the construction industry suffer in terms of low productivity, cost overruns and poor quality due not conducting risks management [1, 2]. The country is confronting the trauma of bridge failures and loss of lives every year due to floods. There is a need to develop risk analysis guidelines to avoid bridge failures. This chapter is to identify risks and critically rank them that affect the performance of project time and cost. Monte Carlo (MC) simulation on a case study project determines that risk analysis is helpful in managing schedule and costs risks. Identifying and analyzing schedule and costs risks on bridge project, this work makes a unique contribution and provides an insight into the risk management concepts.
This work focuses on risk analysis by including a case study bridge project. The research investigates the impact of risks on costs, schedule and suggest guideline for bridge projects. To collect, data, a questionnaire is designed based on the previous studies [1, 15]. The questionnaire includes questions related to respondent identification, years of experience and 37 risk factors. Among the 37 risk factors, 7 are adopted from Choudhry and Iqbal [1], 8 are from Masood and Choudhry [15], 11 from the pilot survey, and 11 are developed by the researcher. These 37 risk factors are divided into 7 categories: design risks, contractual risks, construction risks, management risks, financial risks, health and safety risks, and external risks.
A pilot study is performed with a panel comprising five professionals having over 20 years of experience in construction. The questionnaire is modified based upon the pilot study. Based on importance of impact on the bridge project performance, respondents ranked each risk factor on a 5-point Likert scale (5 = extra ordinary, 4 = major, 3 = moderate, 2 = minor, 1 = insignificant). The respondents comprised on managers and engineers involved with numerous bridge projects. The targeted population for this work included private and public sector clients, consultants, and contractors. These include around 7000 enterprises that are involved in bridge construction projects and are registered with the Pakistan Engineering Council.
According to Dillman et al. [16], a sample size of 61 is fine with ±10% sampling error and a 95% confidence level. The respondents are approached through e-mails and personal visits to construction sites. Overall, 100 surveys forms are distributed on 25 construction sites. The response rate for this survey is 77%, but only 69 are analyzed. Eight surveys forms are not filled properly and thus discarded. Black et al. [17] stated that a 30% response rate is satisfactory in construction. The composition of the respondents is 35% public clients, 10% private clients, 12% contractors and 43% consultants. Public clients own most of the bridge projects. A majority of respondents are civil engineers holding a bachelor’s degree with over 16 years of experience. In addition, 25 interviews are conducted; one at each project. These interviews delivered valuable information about risk management and risk analysis guidelines.
The collected data are analyzed by using a software called as Statistical Package for the Social Sciences (SPSS). Statistical techniques such as preliminary analysis, internal consistency analysis, relative importance index, Pearson’s product–moment correlation are used in the analysis.
In addition, a case study of a bridge project is documented to establish costs and time risk analysis. The researcher obtained assistance from the five-member expert panel (comprising on scheduling manager, project manager, resident engineer, construction manager, an academia) and Monte Carlo simulation to analyze risks on of the case study project. The panel members are having more than 20 years of experience in industry and academics. This panel identifies the risks relevant to the case study project and assigned probability to the risk factors. This panel assigned the probabilistic (optimistic, most likely, pessimistic) durations and costs in Pakistan Rupees (PKR). These probabilistic durations and costs permitted us to practice triangular distribution in Primavera Pertmaster. A 3 days’ workshop is held with the attendance of all panel members. Their involvements for the risk analysis are documented.
Kaiser-Mayer-Olkin (KMO) test and Bartlett’s test of sphericity are carried out to check the suitability for factor analysis. The suitability of a sample in relations to the distribution of the data is checked by KMO test. Pallant [18] stated that KMO value should be more than 0.5. The researchers [18, 19] revealed that factor analysis is meaningless with an identity matrix. The tests showed that KMO value is 0.689 that is more than 0.5 and Bartlett’s test of sphericity is large (chi-square value = 1626.4890 with small significance (p value < 0.001).
Cronbach’s alpha (α) is used to check the internal consistency in the items involved in each factor [20] and the minimum recommended value is α = 0.7 [19]. Cronbach’s α [19] also measures the reliability of all factors. Factor analysis shows that all 7 themes of the 37 factors had Cronbach’s α ranging from 0.921 to 0.912, which means that all the variables are reliable [19]. For all 37 variables, the overall α is 0.917.
Chan and Kumaraswamy [21] reveal that the mean and standard deviation of individual factor are not appropriate to decide the total ranking as they do not indicate any association among the factors. As a substitute, we calculate the weighted average for every factor and formerly divide them with the highest scale of the dimension. The researchers [19, 21, 22] indicate that this results in a relative importance index. Respondents provide their responses on a Likert scale about the standing of the 37 risks affecting the cost and schedule aims of the project. Shash [22] provided the formula for relative importance index as:
where ‘
The relative importance index categorized the seven risk factors in descending order as: financial risks (RII = 69.95), external risks (RII = 66.67), design risks (RII = 66.28), management risks (RII = 65.17), construction risks (RII = 62.72), contractual risks (RII = 59.42), and health and safety risks (RII = 53.82). According to the results, financial risks are vital in affecting the cost and schedule aims of projects (see Table 1). The 2nd and 3rd most important risks are external risks and design risks.
Risk category | Relative importance index (RII) |
---|---|
Financial risk | 69.95 |
External risk | 66.67 |
Design risk | 66.28 |
Management risk | 65.17 |
Construction risk | 62.72 |
Contractual risk | 59.42 |
Health and safety risk | 53.82 |
RII of risk categories.
Among the 37 factors, the highest 10 risk factors in order of importance are: unavailability of funds (RII = 85.80), financial failure of contractor (RII = 76.52), poor site management and supervision (RII = 74.20), inadequate site investigation (RII = 73.91), inadequate project planning (RII = 73.91), construction delays (RII = 73.62), unavailability of land and/or right of way for site access (RII = 72.17), defective work and or quality issue (RII = 71.88), financial delays (RII = 71.01), insufficient technology (RII = 69.86). These risk factors are important for clients, consultants and contractors. There is a need for an effective risk management system on construction projects. Health and safety risks are ranked at the bottom in the 37 factors. This indicates that clients and consultants do not demand from contractors to implement a proper health and safety management system. Management risks are rated with high importance. There is lack of construction management experts and only few institutions offer program in construction management. Small contractors generally do not hire qualified engineers unless it is mandatory by the client. There is a need for construction management and risk management education as well as research in the industry.
The Pearson product-moment correlation (‘r’ Rho) is a measure of the degree of linear relationship among the variables. The correlation coefficient (‘r’ Rho) is any value between plus and minus and the sign (±) explains the direction of the relationship, either positive or negative. A positive coefficient means that the value of the variable increases with the increase in value of the other variable; or if one goes down, the other also reduces. A negative coefficient indicates that as one variable increases, the other decreases, and vice-versa. The absolute value of the coefficient indicates the strength of the correlation. A coefficient of r = 0.50 shows a robust degree of linear relationship than that of r = 0.30. A coefficient of zero (r = 0.0) shows the lack of a linear relationship and coefficients of r = +1.0 and r = −1.0 show a perfect linear relationship [19].
Table 2 shows the Pearson’s correlations for the risk factor categories. The maximum coefficient (0.756) is between the construction and management risks, which is significant at the p value = 0.01. This indicates that numerous construction and management risks are correlated to each other and they are to be jointly addressed with good risk management practices. There is another essential coefficient of 0.605 at significance p value = 0.01 between construction and external risks. External risks impact on project costs and schedule more than the construction risks (see Table 1). They are in fact the second most important risk factor category. A positive correlation of health and safety risks with construction (0.459) at a significance p value = 0.01 confirms the importance of health and safety on bridge projects. Higher rate of risks in construction indicate an increase in physical vulnerabilities. The health and safety risks are correlated positively with contractual risks (0.428) at a significance p value = 0.01, indicating improvement in health and safety in construction may reduce contractual and health and safety risks.
Risk factor category | Financial | Contractual | Design | Safety | Management | Construction | External |
---|---|---|---|---|---|---|---|
Financial | 1 | ||||||
Contractual | .442** | 1 | |||||
Design | .306* | .374** | 1 | ||||
Safety | .098 | .428** | .341** | 1 | |||
Management | .174 | .445** | .374** | .366** | 1 | ||
Construction | .113 | .380** | .250* | .459** | .756** | 1 | |
External | .162 | .290* | .399** | .373** | .430** | .605** | 1 |
Pearson’s product-moment correlation of risk factor categories.
Correlation is significant at 0.05 level.
Correlation is significant at 0.01 level.
The case study project is a bridge construction in Islamabad that links the Islamabad highway with a residential community. The project is located in the capital city of Pakistan. It has the following features: (a) bridge total length 166 m (544.8 ft), (b) constructed over a river with an annual peak discharge of 11,170 cusecs, (c) 56 piles of diameter 762 mm (2.5 ft) and abutment piles 15.24 m (50 feet) deep, (d) 4 spans, (e) pier piles 9.14 m (30 feet) deep, (f) 12 pile caps, (g) 4 abutment walls, (h) 2 abutments, (i) 12 piers, (j) 6 transoms or cross-beams, (k) 24 precast girders of 44.09 m (144.66 ft), (l) 14.32 m (47 feet) width of deck slab on one side, (m) 3.66 m (12 feet) length of approach slab on each side and, (n) asphalt 166.12 m (545 ft) long and the bridge is designed for 3 + 3 lanes of traffic.
A baseline work schedule is prepared for the project. The project has a base cost-estimate. Each activity in the schedule had its cost allocated. The allocation includes cost estimate for materials, equipment, labor, and overhead costs for each activity. The risks that are identified in the project are presented to the experts. The expert panel identifies specific risks to the case study project. These risks are loaded into the schedule to determine the impact on project schedule and cost. Primavera Pertmaster is used for risk analysis. The inputs to Pertmaster for the risk register are: (a) risk description, (b) risk ID number, (c) threat or opportunity, (d) effect of this risk on activity, (e) probability of occurrence, (f) type of risk e.g. schedule or cost, (g) distribution e.g. triangular, (h) correlation with other risk factors. The risk register (see Figure 1) is developed for the whole project.
Risk register of the project.
Pertmaster uses Monte Carlo simulation for risk analysis. Monte Carlo simulation uses random independent variables to obtain solutions of problems. Lian and Yen [23] reveal that Latin hypercube sampling and simple random number sampling are among the sampling techniques that are used with Monte Carlo simulations. This simple and elegant method delivered a means to solve equations with triangular probability distributions [24, 25]. Critical path is found and further calculations are documented with activities that are on the critical path. The time schedule loaded with costs and risks is analyzed. Real versus simulation outcomes are compared. A total of 1000 iterations are conducted for risk analysis.
The cumulative distribution for project cost, finish date, and duration are calculated with Monte Carlo simulations. The project duration (maximum = 792 days, minimum = 628 days, mean = 701 days) is displayed in Figure 2. The cumulative distribution for project duration and cost is determined. The results showed that the probability of finishing the project within the allotted time (628 days) is 4% and within the budget (PKR 129 million) is less than 1%. Terms P100 and P80 indicate the probabilities of 100 and 80% respectively. For instance, P80 shows that the project could be completed in 730 days with an amount of PKR 161 Million. There shall be 100% sure that the project would be completes in 792 days or even less with a cost amounting to PKR 166.5 Million or less.
Monte Carlo simulation results.
The observations are performed for 5 months for the case study project. We have compared Pertmaster results with the actual completed activities. The researchers spent full time on-site to ensure extreme communication with the project implementation team. Documents are cautiously reviewed and are assimilated in analysis. On-site real data are equated with the simulation outcomes. The evaluation associated with schedule start dates is noted. For piling activity, actual start dates matched with the base line as well as with P80 and P100. For pier-shaft, actual start dates are between P80 and P100.
Finish dates are also compared for the case study project. Piles activity finishes between the forecasted dates of P80 and P100. Pile-cap activity finishes between the expected dates of P80 and P100. The ‘pier-shaft’ activity also accomplished 22 days before the P80 finish date. Transom activity finishes 19 days after the P100 completion. This indicates that the simulation results are precise as the activities are actually completing either within the predicted dates or within ±20 days.
For the case study, costs are compared that are important to the contract partners. The project cost is at all times important to the management team. Probabilistic cost calculation with the model is very precise as all the genuine costs fell within the P80 and P100. The project cost incurred up to the completion of transoms is PKR 72.8 Million, while that forecasted by simulation with 80% probability is PKR 69.8 Million. The evaluation is PKR 76.0 Million with 100% probability, indicating that the expected cost using Monte Carlo simulation is precise (P80 costs = 69.8 Million, Actual = 72.8 Million, P100 costs = 76.0 Million). The baseline cost of the project is only PKR 37.2 Million up to ‘Transoms’ construction that shows a cost overrun of 96%, portraying the absenteeism of monitoring and control of cost practices. This shows a clear requirement of risk management on bridge construction projects.
For the case study project, risk analysis shows that project management can obtain a fair idea of schedule and cost changes and variations. For the case study project, risks (see Figure 1) that affected the schedule and cost objectives are: (a) delay in approval from the regulatory authority i.e. delay in sanctioning relocation of the railway track, (b) unexpected weather i.e. excess rainfall during monsoon, (c) design variations i.e. design changes due to insufficient site investigation, (d) insufficient work space i.e. land not available for pre-casting of girders, (e) lack of technology i.e. breakdown in asphalt paving equipment, (f) unavailability of funds i.e. delay in payment to subcontractor, (g) unavailability of material i.e. quality issues and material failure to meet specifications.
The study advocates the succeeding guidelines for an effective risk analysis of any bridge project:
This work reveals a systematic process to identify and quantify major risks related to construction and predominantly to bridge construction affecting cost and schedule of the project. All projects have their own special conditions; nonetheless, experts can acquire valuable evidence from the results as all projects have risks that need to be managed. Risks related to schedule create cost risk. The case study demonstrates with the help of Monte Carlo simulation that how schedule and cost risk can be analyzed and managed. The case study shows that understanding the probabilistic cost is vital to forecast long-term budgets. The risk management guidelines are documented from surveys, interviews and analysis. One can determine the probabilistic cost of project by adopting these guidelines.
This work has identified and ranked the critical risks threatening the performance of bridge construction projects and evaluated the consequence of risks on project time and cost. This work is planned to developed consciousness of project stakeholders in relation to risk analysis in the construction industry. The major risks concerning a bridge construction project are identified. After carrying out risk analysis, the major results of this work are examination of critical risks affecting project costs and schedule. Relative importance index of important risk factors is calculated. This exercise categorized risk that include ‘financial risks’, ‘design risks’, ‘external risks’, ‘management risks’, ‘contractual risks’, ‘health & safety risks’ and ‘construction risks’. Financial risks are categorized at the top. The five highest ranked risk factors are ‘financial failure of contractor’, ‘unavailability of funds’, ‘poor site management & supervision’, ‘inadequate project planning’ and ‘inadequate site investigation’ among the 37 factors. Many risks are correlated and they need to be managed by applying management practices.
Schedule and costs risks are investigated in a case study project of a bridge construction. Real data of the bridge construction project is compared with simulation results after the risk analysis. Simulation findings are precisely correct and comparable to those really performed in relations to project duration and cost. In addition, guidelines for risk analysis are developed that can assist management in ascertaining possible risks on construction project of bridges. The research stresses that management is required to perform risks analysis after identifying prospective risks at the initial stage of bridge projects. Predicting risks can enable policymakers to detect areas of anxiety for project managers to take preemptive actions.
Although, each project in construction has its particular circumstances, project managers can acquire positive information from this study for their projects as the risks recognized for the construction are alike to risks in all sorts of projects across the world. The evidence delivered through this investigation can empower engineering professionals to safeguard that their projects advance efficiently without making unnecessary errors. This would be supportive to improve the execution of their projects. Even though there is some body of awareness in relation to management of risks, the formation of guidelines for risk management persisted to be vague. This research provided guidelines for risks management accompanying with heavy engineering construction in the construction sector. The research is important for project managers, academicians and professionals who are linked with heavy engineering construction and the construction sector in common.
This is a brief overview of the main steps involved in publishing with IntechOpen Compacts, Monographs and Edited Books. Once you submit your proposal you will be appointed a Author Service Manager who will be your single point of contact and lead you through all the described steps below.
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The nanoparticles’ unique physical and chemical properties render them most appropriate for a number of specialist applications.",book:{id:"9109",slug:"engineered-nanomaterials-health-and-safety",title:"Engineered Nanomaterials",fullTitle:"Engineered Nanomaterials - Health and Safety"},signatures:"Takalani Cele",authors:[{id:"305934",title:"Dr.",name:"Takalani",middleName:null,surname:"Cele",slug:"takalani-cele",fullName:"Takalani Cele"}]},{id:"72636",title:"Nanocomposite Materials",slug:"nanocomposite-materials",totalDownloads:2139,totalCrossrefCites:5,totalDimensionsCites:11,abstract:"Nanocomposites are the heterogeneous/hybrid materials that are produced by the mixtures of polymers with inorganic solids (clays to oxides) at the nanometric scale. Their structures are found to be more complicated than that of microcomposites. They are highly influenced by the structure, composition, interfacial interactions, and components of individual property. Most popularly, nanocomposites are prepared by the process within in situ growth and polymerization of biopolymer and inorganic matrix. With the rapid estimated demand of these striking potentially advanced materials, make them very much useful in various industries ranging from small scale to large to very large manufacturing units. With a great deal to mankind with environmental friendly, these offer advanced technologies in addition to the enhanced business opportunities to several industrial sectors like automobile, construction, electronics and electrical, food packaging, and technology transfer.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Mousumi Sen",authors:[{id:"310218",title:"Dr.",name:"Mousumi",middleName:null,surname:"Sen",slug:"mousumi-sen",fullName:"Mousumi Sen"}]},{id:"38951",title:"Carbon Nanotube Transparent Electrode",slug:"carbon-nanotube-transparent-electrode",totalDownloads:3985,totalCrossrefCites:3,totalDimensionsCites:5,abstract:null,book:{id:"3077",slug:"syntheses-and-applications-of-carbon-nanotubes-and-their-composites",title:"Syntheses and Applications of Carbon Nanotubes and Their Composites",fullTitle:"Syntheses and Applications of Carbon Nanotubes and Their Composites"},signatures:"Jing Sun and Ranran Wang",authors:[{id:"153508",title:"Prof.",name:"Jing",middleName:null,surname:"Sun",slug:"jing-sun",fullName:"Jing Sun"},{id:"153596",title:"Ms.",name:"Ranran",middleName:null,surname:"Wang",slug:"ranran-wang",fullName:"Ranran Wang"}]},{id:"49413",title:"Electrodeposition of Nanostructure Materials",slug:"electrodeposition-of-nanostructure-materials",totalDownloads:3732,totalCrossrefCites:1,totalDimensionsCites:7,abstract:"We are conducting a multi-disciplinary research work that involves development of nanostructured thin films of semiconductors for different applications. Nanotechnology is widely considered to constitute the basis of the next technological revolution, following on from the first Industrial Revolution, which began around 1750 with the introduction of the steam engine and steelmaking. Nanotechnology is defined as the design, characterization, production, and application of materials, devices and systems by controlling shape and size of the nanoscale. The nanoscale itself is at present considered to cover the range from 1 to 100 nm. All samples prepared in thin film forms and the characterization revealed their nanostructure. The major exploitation of thin films has been in microelectronics, there are numerous and growing applications in communications, optical electronics, coatings of all kinds, and in energy generation. A great many sophisticated analytical instruments and techniques, largely developed to characterize thin films, have already become indispensable in virtually every scientific endeavor irrespective of discipline. Among all these techniques, electrodeposition is the most suitable technique for nanostructured thin films from aqueous solution served as samples under investigation. The electrodeposition of metallic layers from aqueous solution is based on the discharge of metal ions present in the electrolyte at a cathodic surface (the substrate or component.) The metal ions accept an electron from the electrically conducting material at the solid- electrolyte interface and then deposit as metal atoms onto the surface. The electrons necessary for this to occur are either supplied from an externally applied potential source or are surrendered by a reducing agent present in solution (electroless reduction). The metal ions themselves derive either from metal salts added to solution, or by the anodic dissolution of the so-called sacrificial anodes, made of the same metal that is to be deposited at the cathode.",book:{id:"4718",slug:"electroplating-of-nanostructures",title:"Electroplating of Nanostructures",fullTitle:"Electroplating of Nanostructures"},signatures:"Souad A. M. Al-Bat’hi",authors:[{id:"174793",title:"Dr.",name:"Mohamad",middleName:null,surname:"Souad",slug:"mohamad-souad",fullName:"Mohamad Souad"}]},{id:"71346",title:"Application of Nanomaterials in Environmental Improvement",slug:"application-of-nanomaterials-in-environmental-improvement",totalDownloads:1691,totalCrossrefCites:0,totalDimensionsCites:13,abstract:"In recent years, researchers used many scientific studies to improve modern technologies in the field of reducing the phenomenon of pollution resulting from them. In this chapter, methods to prepare nanomaterials are described, and the main properties such as mechanical, electrical, and optical properties and their relations are determined. The investigation of nanomaterials needed high technologies that depend on a range of nanomaterials from 1 to 100 nm; these are scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffractions (XRD). The applications of nanomaterials in environmental improvement are different from one another depending on the type of devices used, for example, solar cells for producing clean energy, nanotechnologies in coatings for building exterior surfaces, and sonochemical decolorization of dyes by the effect of nanocomposite.",book:{id:"10072",slug:"nanotechnology-and-the-environment",title:"Nanotechnology and the Environment",fullTitle:"Nanotechnology and the Environment"},signatures:"Ali Salman Ali",authors:[{id:"313275",title:"Associate Prof.",name:"Ali",middleName:null,surname:"Salman",slug:"ali-salman",fullName:"Ali Salman"}]}],onlineFirstChaptersFilter:{topicId:"208",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81438",title:"Research Progress of Ionic Thermoelectric Materials for Energy Harvesting",slug:"research-progress-of-ionic-thermoelectric-materials-for-energy-harvesting",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.101771",abstract:"Thermoelectric material is a kind of functional material that can mutually convert heat energy and electric energy. It can convert low-grade heat energy (less than 130°C) into electric energy. Compared with traditional electronic thermoelectric materials, ionic thermoelectric materials have higher performance. The Seebeck coefficient can generate 2–3 orders of magnitude higher ionic thermoelectric potential than electronic thermoelectric materials, so it has good application prospects in small thermoelectric generators and solar power generation. According to the thermoelectric conversion mechanism, ionic thermoelectric materials can be divided into ionic thermoelectric materials based on the Soret effect and thermocouple effect. They are widely used in pyrogen batteries and ionic thermoelectric capacitors. The latest two types of ionic thermoelectric materials are in this article. The research progress is explained, and the problems and challenges of ionic thermoelectric materials and the future development direction are also put forward.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jianwei Zhang, Ying Xiao, Bowei Lei, Gengyuan Liang and Wenshu Zhao"},{id:"77670",title:"Thermoelectric Elements with Negative Temperature Factor of Resistance",slug:"thermoelectric-elements-with-negative-temperature-factor-of-resistance",totalDownloads:71,totalDimensionsCites:0,doi:"10.5772/intechopen.98860",abstract:"The method of manufacturing of ceramic materials on the basis of ferrites of nickel and cobalt by synthesis and sintering in controllable regenerative atmosphere is presented. As the generator of regenerative atmosphere the method of conversion of carbonic gas is offered. Calculation of regenerative atmosphere for simultaneous sintering of ceramic ferrites of nickel and cobalt is carried out. It is offered, methods of the dilated nonequilibrium thermodynamics to view process of distribution of a charge and heat along a thermoelement branch. The model of a thermoelement taking into account various relaxation times of a charge and warmth is constructed.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Yuri Bokhan"},{id:"79236",title:"Processing Techniques with Heating Conditions for Multiferroic Systems of BiFeO3, BaTiO3, PbTiO3, CaTiO3 Thin Films",slug:"processing-techniques-with-heating-conditions-for-multiferroic-systems-of-bifeo3-batio3-pbtio3-catio",totalDownloads:96,totalDimensionsCites:0,doi:"10.5772/intechopen.101122",abstract:"In this chapter, we have report a list of synthesis methods (including both synthesis steps & heating conditions) used for thin film fabrication of perovskite ABO3 (BiFeO3, BaTiO3, PbTiO3 and CaTiO3) based multiferroics (in both single-phase and composite materials). The processing of high quality multiferroic thin film have some features like epitaxial strain, physical phenomenon at atomic-level, interfacial coupling parameters to enhance device performance. Since these multiferroic thin films have ME properties such as electrical (dielectric, magnetoelectric coefficient & MC) and magnetic (ferromagnetic, magnetic susceptibility etc.) are heat sensitive, i.e. ME response at low as well as higher temperature might to enhance the device performance respect with long range ordering. The magnetoelectric coupling between ferromagnetism and ferroelectricity in multiferroic becomes suitable in the application of spintronics, memory and logic devices, and microelectronic memory or piezoelectric devices. In comparison with bulk multiferroic, the fabrication of multiferroic thin film with different structural geometries on substrate has reducible clamping effect. A brief procedure for multiferroic thin film fabrication in terms of their thermal conditions (temperature for film processing and annealing for crystallization) are described. Each synthesis methods have its own characteristic phenomenon in terms of film thickness, defects formation, crack free film, density, chip size, easier steps and availability etc. been described. A brief study towards phase structure and ME coupling for each multiferroic system of BiFeO3, BaTiO3, PbTiO3 and CaTiO3 is shown.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Kuldeep Chand Verma and Manpreet Singh"},{id:"78034",title:"Quantum Physical Interpretation of Thermoelectric Properties of Ruthenate Pyrochlores",slug:"quantum-physical-interpretation-of-thermoelectric-properties-of-ruthenate-pyrochlores",totalDownloads:75,totalDimensionsCites:0,doi:"10.5772/intechopen.99260",abstract:"Lead- and lead-yttrium ruthenate pyrochlores were synthesized and investigated for Seebeck coefficients, electrical- and thermal conductivity. Compounds A2B2O6.5+z with 0 ≤ z < 0.5 were defect pyrochlores and p-type conductors. The thermoelectric data were analyzed using quantum physical models to identify scattering mechanisms underlying electrical (σ) and thermal conductivity (κ) and to understand the temperature dependence of the Seebeck effect (S). In the metal-like lead ruthenates with different Pb:Ru ratios, σ (T) and the electronic thermal conductivity κe (T) were governed by ‘electron impurity scattering’, the lattice thermal conductivity κL (T) by the 3-phonon resistive process (Umklapp scattering). In the lead-yttrium ruthenate solid solutions (Pb(2-x)YxRu2O(6.5±z)), a metal–insulator transition occurred at 0.2 moles of yttrium. On the metallic side (<0.2 moles Y) ‘electron impurity scattering’ prevailed. On the semiconductor/insulator side between x = 0.2 and x = 1.0 several mechanisms were equally likely. At x > 1.5 the Mott Variable Range Hopping mechanism was active. S (T) was discussed for Pb-Y-Ru pyrochlores in terms of the effect of minority carrier excitation at lower- and a broadening of the Fermi distribution at higher temperatures. The figures of merit of all of these pyrochlores were still small (≤7.3 × 10−3).",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Sepideh Akhbarifar"},{id:"77635",title:"Optimization of Thermoelectric Properties Based on Rashba Spin Splitting",slug:"optimization-of-thermoelectric-properties-based-on-rashba-spin-splitting",totalDownloads:124,totalDimensionsCites:0,doi:"10.5772/intechopen.98788",abstract:"In recent years, the application of thermoelectricity has become more and more widespread. Thermoelectric materials provide a simple and environmentally friendly solution for the direct conversion of heat to electricity. The development of higher performance thermoelectric materials and their performance optimization have become more important. Generally, to improve the ZT value, electrical conductivity, Seebeck coefficient and thermal conductivity must be globally optimized as a whole object. However, due to the strong coupling among ZT parameters in many cases, it is very challenging to break the bottleneck of ZT optimization currently. Beyond the traditional optimization methods (such as inducing defects, varying temperature), the Rashba effect is expected to effectively increase the S2σ and decrease the κ, thus enhancing thermoelectric performance, which provides a new strategy to develop new-generation thermoelectric materials. Although the Rashba effect has great potential in enhancing thermoelectric performance, the underlying mechanism of Rashba-type thermoelectric materials needs further research. In addition, how to introduce Rashba spin splitting into current thermoelectric materials is also of great significance to the optimization of thermoelectricity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Zhenzhen Qin"},{id:"75364",title:"Challenges in Improving Performance of Oxide Thermoelectrics Using Defect Engineering",slug:"challenges-in-improving-performance-of-oxide-thermoelectrics-using-defect-engineering",totalDownloads:214,totalDimensionsCites:0,doi:"10.5772/intechopen.96278",abstract:"Oxide thermoelectric materials are considered promising for high-temperature thermoelectric applications in terms of low cost, temperature stability, reversible reaction, and so on. Oxide materials have been intensively studied to suppress the defects and electronic charge carriers for many electronic device applications, but the studies with a high concentration of defects are limited. It desires to improve thermoelectric performance by enhancing its charge transport and lowering its lattice thermal conductivity. For this purpose, here, we modified the stoichiometry of cation and anion vacancies in two different systems to regulate the carrier concentration and explored their thermoelectric properties. Both cation and anion vacancies act as a donor of charge carriers and act as phonon scattering centers, decoupling the electrical conductivity and thermal conductivity.",book:{id:"10037",title:"Thermoelectricity - Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10037.jpg"},signatures:"Jamil Ur Rahman, Gul Rahman and Soonil Lee"}],onlineFirstChaptersTotal:6},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 18th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. 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She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:49,paginationItems:[{id:"80495",title:"Iron in Cell Metabolism and Disease",doi:"10.5772/intechopen.101908",signatures:"Eeka Prabhakar",slug:"iron-in-cell-metabolism-and-disease",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Iron Metabolism - Iron a Double‐Edged Sword",coverURL:"https://cdn.intechopen.com/books/images_new/10842.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81799",title:"Cross Talk of Purinergic and Immune Signaling: Implication in Inflammatory and Pathogenic Diseases",doi:"10.5772/intechopen.104978",signatures:"Richa Rai",slug:"cross-talk-of-purinergic-and-immune-signaling-implication-in-inflammatory-and-pathogenic-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81764",title:"Involvement of the Purinergic System in Cell Death in Models of Retinopathies",doi:"10.5772/intechopen.103935",signatures:"Douglas Penaforte Cruz, Marinna Garcia Repossi and Lucianne Fragel Madeira",slug:"involvement-of-the-purinergic-system-in-cell-death-in-models-of-retinopathies",totalDownloads:5,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Purinergic System",coverURL:"https://cdn.intechopen.com/books/images_new/10801.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"81756",title:"Alteration of Cytokines Level and Oxidative Stress Parameters in COVID-19",doi:"10.5772/intechopen.104950",signatures:"Marija Petrusevska, Emilija Atanasovska, Dragica Zendelovska, Aleksandar Eftimov and Katerina Spasovska",slug:"alteration-of-cytokines-level-and-oxidative-stress-parameters-in-covid-19",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}}]},overviewPagePublishedBooks:{paginationCount:27,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. 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