Kotb Abdelmohsen

Kotb Abdelmohsen was born in Egypt. He studied at Ain Shams University, Cairo, Egypt, where he received a B.Sc. degree in chemistry and biochemistry in 1995-1996. From 1996 to 2000, he joined the Biochemistry department at Oslo University, Norway, where he received a master degree in biochemistry. From 2000 to 2003, he was a Fellow at Heinrich Heine University (Duesseldorf), Germany, school of medicine, where he received a Ph.D. degree in biochemistry. From 2004 to 2009 he was a post-doc at the National Institutes of Health (NIH), National Institutes on Aging. Currently he is a Staff Scientist at the NIH. For several years his work focused on the mechanisms that regulate gene expression patterns under different conditions including cell damage and diseases such as cancer. He is particularly interested in post-transcriptional processes, mRNA turnover and translation.  His studies include global and gene-specific analyses of mRNA stability and translation, the identification of target RNA sequences associated with RNA-binding proteins (RBPs) that modulate mRNA stability and translation, the elucidation of the functions of RBP function in response to stress agents and proliferative signals, the investigation of microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) that modulate gene expression, cell proliferation, replicative senescence, and aging.

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Latest work with IntechOpen by Kotb Abdelmohsen

Proteins are essential for all cellular events. They bind or interact with additional players such as other proteins, peptides, DNA, and RNA to exert their functions. Revealing protein binding partners is important in understanding the mechanisms through which they function in the cells and the organism. These interactions are essential in the regulation of cell fates and could be important in drugs development. For example proteins can bind mRNA to regulate stability and translation. They also bind other proteins for degradation or proteolysis. These mRNAs and proteins could be involved in cellular processes such as cell survival or apoptosis. This book contains review articles dealing with protein interactions with the above mentioned factors. The enclosed articles could be informative and stimulating for readers interested in protein binding partners and the consequences of such interactions.

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