Dr. Filip Nina is an associate professor in the field of Biochemistry at the Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy in Iași. His scientific interests include the role of homocysteine in pathology, endothelial dysfunction mechanisms in cardiovascular diseases, oxidative stress, and implications of biogenic amines in human pathology.
The first description of homocysteine (Hcy), a non-proteinogenic amino acid, was introduced in a case study more than 70 years ago. In recent years, numerous studies have shown a positive correlation between serum levels and various diseases, especially vascular pathology. Vitamins B6, B12, and folic acid play a major role in controlling homocysteine levels. In this book are presented both methods for the determination of homocysteine and its involvement in human pathology. Homocysteine levels can be taken as an early indicator for the detection of cardiovascular diseases because Hcy levels increase after a myocardial infarction or stroke.
Go to the bookReactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. In the last decade, studies have indicated that ROS, including superoxide and hydrogen peroxide, are crucial components that regulate the differentiation process of osteoclasts. Osteoclasts (OCs), cells specialized for bone resorption, utilize ROS as second messengers during receptor activator of NF-κB ligand (RANKL)-induced differentiation and activation. The purpose of this chapter is to explore the current understanding of reactive oxygen species involvement in bone pathophysiology.
Part of the book: Reactive Oxygen Species (ROS) in Living Cells