Anna Tolekova

Trakia UniversityBulgaria

Anna Naydenova Tolekova was born on August 18, 1955. In 1979, she graduated from the Higher Medical School, Plovdiv, Bulgaria. From 1979 to 1983, she worked as the epidemiologist in Gabrovo. From 1983 until now, she has been working in Medical Faculty, Trakia University, Stara Zagora in the Department of Physiology. Since 2009, she has been an associate professor, and since 2016, she has been a professor. Since 2012, she has been the head of the Department of Physiology, Pathophysiology, and Pharmacology. From 2012 till the end of 2015, she was the vice rector of the Research and International Activities of the Trakia University, Stara Zagora, Bulgaria. In 1989, she earned her PhD degree in Physiology. The subject of the dissertation is “Investigation of plasma renin activity after some physiological and pharmacological effects.” Her scientific field includes endocrine function of the kidney, neuroendocrine regulation of smooth muscle contractility, oxidative balance, and new mathematical methods in physiological research. She has authored 98 publications and 3 book chapters.

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Latest work with IntechOpen by Anna Tolekova

Exploring the contractile activity of smooth muscle segments isolated from various organs of healthy animals and animals with experimentally induced diabetes, she obtained original data about angiotensin II-induced force and time parameters. For the first time, she established the effect of ghrelin on angiotensin II-provoked contraction of the urinary bladder. Original data on the role of both types of angiotensin receptors for the contractile activity of the various segments of the gastrointestinal tract and bladder were obtained. By applying specific software for force and time parameter analysis, the contribution of different types of angiotensin receptors on muscle contractility has been shown. The new methodology was used to analyze the data obtained during the registration of smooth muscle relaxation activity, which allows the determination of not only the magnitude of the mechanical response but also the parameters related to the time and speed of the contractions. Plasma renin activity models have been developed using mathematical approaches to predict the effect of different drug doses on the behavior of the system.

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