Filip Cristiana

Dr. Filip has accumulated experience in the field of pharmacokinetic, drug-delivery systems and HPLC by accomplishing the PhD 2001 thesis entitled: “Analytical Methods for the Bioavailability Estimation of some Drugs Bound on Polymeric Support” at “Al. I. Cuza” University, Iasi, Romania. She also acquired knowledge in reactive species involvement in pathological processes, homocysteine role in pathology, and in mechanisms of endothelial dysfunction in cardiovascular diseases as team member of related projects.

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Latest work with IntechOpen by Filip Cristiana

Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.

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