The circadian clock is an endogenous timer in prokaryotes and mammals. Resting and adjusting the internal clock can assist in pacing the daily routine. Growing evidence indicates that the circadian clock and aging process are closely associated. The disruption of the circadian clock leads to accelerated aging and increased incidence of various diseases. In particular, elderly people are more vulnerable and have a higher risk of diseases than do young people. In this study, we reviewed studies on aging and circadian rhythms over the last decade, with a focus on circadian clock gene regulation in aging and drug discovery for targeting the circadian clock in diseases.
Part of the book: Molecular Mechanisms of the Aging Process and Rejuvenation
Traditional Chinese medicine (TCM) is a traditional healing system with unique theoretical system. The Zang‐Fu theory is the closest mapping to body's physiological and pathological changes. Kidney is the most vital Zang organ in TCM system. However, the material basis of kidney essence is still undefined. In this chapter, we propose the idea that kidney endocrine substances, such as renin, kallikrein, erythropoietin (EPO), calcitriol, bone morphogenetic protein (BMP)‐7, and klotho, are potential candidates of the material basis of kidney essence. In addition, kidney‐nourishing therapy and related Chinese medicinal herbs are also introduced.