Tejinder Kataria

Medanta The MedicityIndia

Dr Tejinder Kataria is the Chairperson , Division of Radiation Oncology at Medanta-the Medicity, Gurgaon, India.After her graduation she pursued MD in Radiotherapy followed by a fellowship for intraluminal brachytherapy. She then went on to hone her skills in Brachytherapy for flexible Iridium 192 interstitial implants and permanent Iodine125 seed implants for prostate, while on a Commonwealth scholarship. She returned to India and started the department of Radiotherapy in one of the premier cancer centers in Delhi. She trained at DKFZ and implemented Intensity Modulated Radiotherapy in the country in 2001-02.Subsequently the quest for learning took her to Mannheim Klinikum, in 2007 for image guided radiotherapy and in 2010 for volumetric arc therapy . She started frameless Linac based stereotaxy in 2010 after training at Wurzburg .She was instrumental in bringing the first the Cyberknife- VSI system to her country. Her efforts have been towards implementing conformal radiation therapy techniques and advancements for the benefit of her patients and training the younger generation in the art and science of cancer care.

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Latest work with IntechOpen by Tejinder Kataria

The mode of action by radiation is postulated to be the production of double strand breaks of DNA. The repair of double strand breaks occurs through non homologous end joining through acetylation of histone proteins by histone acetyltransferases (HATs). The fixation of double strand breaks through HAT inhibitors is a promising application for radiation sensitization in the clinic. P53 is a tumour suppressor gene and its mutation has been implicated in 60% of human cancers. As one of the pivotal anticancer genes, P53 controls the transcription and translation of a series of genes. The kinetics of DNA double strand break generation and their co relation to P53 status, ATM and ARF activation are computed and modelled for understanding the potential of such research.

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